IN PROVENCE International Updates Meet& the Expert

SEPTEMBER 6th - 9th 2O17 Palais des Papes - Convention Centre Avignon (France)

SCIENTIFIC COORDINATORS FACULTY/COORDINATORS Umberto Simeoni (Lausanne) Eduardo Bancalari (Miami) Jean-François Tolsa (Lausanne) Virgilio Carnielli (Ancona) Neil Marlow (London) Ola D. Saugstad (Oslo) Paolo Manzoni (Turin)

PATRONAGE Welcome to Provence,

The Summer Conference on Neonatology has been planned to offer neonatologists and neonatal care professionals from all countries the unique combination of scientific excellence and the particular, relaxed atmosphere offered by Provence, during a few days at the end of the summer.

This meeting is based upon an exceptionnal combination of: - the highest level of science possible in selected, - key neonatology domains, - and an unformal, summer atmosphere, in the relaxing landscapes and lifestyle of Provence. This edition will offer an outstanding faculty, as well as an increased coverage of hot topics, with the addition of perinatal infectious diseases to the program. This 3rd edition of the Summer Conference will constitute an optimal and useful break before starting the new academic year.

On behalf of the Faculty,

Umberto Simeoni and Jean-François Tolsa,

CHUV & FBM, University of Lausanne, CH

2 SCIENTIFIC COORDINATORS Umberto Simeoni (Lausanne, Switzerland) Jean-Francois Tolsa (Lausanne, Switzerland)

SCIENTIFIC COMMITTEE Eduardo Bancalari (Miami, USA) Virgilio P. Carnielli (Ancona, Italy) Paolo Manzoni (Turin, Italy) Neil Marlow (London, UK) Ola D. Saugstad (Oslo, Norway)

INVITED SPEAKERS Manon Benders (Utrecht, The Netherlands) Peter Davis (Melbourne, Australia) Teresa Del Moral (Miami, USA) Antonio Del Vecchio (Bari, Italy) Nicholas Embleton (Newcastle, UK) Drude Merete Fugelseth (Oslo, Norway) Eric Giannoni (Lausanne, Switzerland) Moshe Hod (Petah-Tiqva, Israel) Alan Jobe (Cincinnati, USA) Samantha J. Johnson (Leicester, UK) David Kaufman (Charlottsville, USA) Torvid Kiserud (Bergen, Norway) Girija Ganesh Konduri (Milwaukee, USA) Patrick McNamara (Toronto, Canada) Yvan Mivelaz (Lausanne, Switzerland) Deirdre Murray (Cork, Ireland) Deborah O’Connors (Toronto, Canada) Jeffrey M. Perlman (New York, USA Pablo Sanchez (Columbus, USA) Laurent Storme (Lille, France) Arjan te Pas (Leiden, The Netherlands) Bernard Thebaud (Ottawa, Canada) Gerry Visser (Utrecht, The Netherlands)

3 WEDNESDAY, 6TH SEPTEMBER 2017

17:00 WELCOME RECEPTION AND POSTER WALK

THURSDAY, 7TH SEPTEMBER 2017

08:15 Welcome address Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland)

08:30 NEURO-COGNITIVE DEVELOPMENT Chairmen: Neil Marlow (London, United Kingdom) Umberto Simeoni (Lausanne, Switzerland)

08:30 Assessment of outcome at 2 years: can we simplify this is for the 21st century child? Deirdre Murray (Cork, Ireland)

09:00 Looking beyond IQ in preterm children Samantha J. Johnson (Leicester, United Kingdom)

09:30 Discussion

10:00 COFFE BREAK

10:20 Predicting outcomes from neonatal MRI Manon Benders (Utrecht, Netherlands)

10:50 Adult outcomes of extremely preterm birth Neil Marlow (London, United Kingdom)

11:20 Discussion

11:45 HYPERGLYCAEMIA IN PREGNANCY: A WORLDWIDE CHALLENGE TO THE MOTHER AND THE INFANT Chairmen: Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland) Speaker: Moshe Hod (Petah-Tiqva, Israel)

4 12:30 POSTER WALK

13:00 BREAK

14:00 NEONATAL INFECTIOUS DISEASE SESSION “CURRENT CHALLENGES IN THE AREA OF NEONATAL INFECTIONS” Chairmen: Paolo Manzoni (Turin, Italy); Jean-François Tolsa (Lausanne, Switzerland)

14:00 Fetal programing of immune responses: relevance to neonatal sepsis Eric Giannoni (Lausanne, Switzerland)

14:20 Challenges and open questions in neonatal immunology. Why neonates are susceptible, which is the room for immunological manipulation Antonio Del Vecchio (Bari, Italy)

14:40 Early and accurate diagnosis is challenging: what tools do we have currently? Which ones in the next future? David Kaufman (Charlottesville, United States)

15:40 Discussion

16:10 COFFE BREAK

16:30 Viral sepsis in the NICU: the new kid on the block. How to suspect, how to manage Pablo Sanchez (Columbus, United States)

17:00 Prevention and management of late-onset sepsis: an update Paolo Manzoni (Turin, Italy)

17:30 Discussion

17:50 UPDATE ON ANTENATAL STEROIDS FOR PRETERM DELIVERY Chairmen: Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland) Speaker: Gerry Visser (Utrecht, The Netherlands)

5 FRIDAY, 8TH SEPTEMBER 2017

08:00 DELIVERY ROOM HANDLING OF THE NEWBORN Chairmen: Ola Didrik Saugstad (Oslo, Norway); Umberto Simeoni (Lausanne, Switzerland)

08:00 Strategies in the delivery room and the first “Golden minutes” Jeffrey M. Perlman (New York, United States)

08:25 Ventilation strategies in the delivery room Arjan te Pas (Leiden, The Netherlands)

08:50 Oxygen in the delivery room: how much? Ola Didrik Saugstad (Oslo, Norway)

09:15 To cut or not to cut the cord, that is the question Arjan te Pas (Leiden, The Netherlands)

09:25 Discussion

09:45 COFFE BREAK

10:15 FETAL AND NEONATAL HEMODYNAMICS: A FOCUS ON ECHOCARDIOGRAPHIC ASSESSMENT Chairmen: Yvan Mivelaz (Lausanne, Switzerland) Jean-François Tolsa (Lausanne, Switzerland);

10:15 Fetal circulation Torvid Kiserud, (Bergen, Norway)

10:45 Transitional and neonatal circulations Patrick McNamara (Toronto, Canada)

11:15 The hostile perinatal environment and the heart Yvan Mivelaz (Lausanne, Switzerland)

11:45 Cardiac dysfunction Drude Merete Fugelseth (Oslo, Norway)

6 12:15 Pulmonary circulation Laurent Storme (Lille, France)

12:45 Discussion

13:00 POSTER WALK

13:30 BREAK

14.30 RESPIRATORY DISORDERS AND ASSISTANCE Chairmen: Eduardo Bancalari (Miami, United States); Umberto Simeoni (Lausanne, Switzerland)

14:30 Respiratory support during transition after birth Peter Davis (Melbourne, Australia)

14:50 Antenatal associations with BPD Alan Hall Jobe (Cincinnati, United States)

15:20 Genetic and epigenetic factors in BPD Ola Didrik Saugstad (Oslo, Norway)

15:50 Discussion

16:10 COFFE BREAK

16:30 Postnatal risk factors for BPD Eduardo Bancalari (Miami, United States)

17:00 Pulmonary hypertension: a consequence of and a contributor to bronchopulmonary dysplasia in premature infants Girija Ganesh Konduri (Milwaukee, United States)

17:20 Lung regeneration: it’s all in the cord Bernard Thebaud (Ottawa, Canada)

17:50 Discussion

7 SATURDAY, 9TH SEPTEMBER 2017

08:30 WOMEN ARE DESIGNED TO DELIVER VAGINALLY AND NOT BY CAESAREAN SECTION Chairmen: Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland) Speaker: Gerry Visser (Utrecht, The Netherlands)

09:15 NUTRITION OF PRETERM INFANTS Chairmen: Virgilio Carnielli (Ancona, Italy); Umberto Simeoni (Lausanne, Switzerland)

09:15 Effect of supplemental donor human milk compared with preterm formula on neurodevelopment of very low-birth-weight infants Deborah O’Connor (Toronto, Canada)

09:45 Discussion

10:15 COFFE BREAK

10:45 Preterm gut microbiome disease outcomes and nutrient interactions Nicholas Embleton (Newcastle, United Kingdom)

11:15 Controversies on the use of probiotics in neonatology Teresa Del Moral (Miami, United states)

11:45 Extra-Uterine Growth Retardation (EUGR) of the small preterm infant: associations and outcome Virgilio Carnielli (Ancona, Italy)

12:15 Round table: too little or too much for the preterm infant Nicholas Embleton (Newcastle, United Kingdom); Virgilio Carnielli (Ancona, Italy)

8 POSTER LIST

POSTER 012 BRAIN IMAGING AND NEURODEVELOPMENTAL OUTCOME OF GROUP B STREPTOCOCCAL MENINGITIS IN NEONATES J. M. S. Martis; L. A. Bok; F. J. J. Halbertsma; H. L. M. van Straaten; L. S. de Vrie; F. Groenendaal

POSTER 013 DOSE EVALUATION IN NEONATAL X-RAY IMAGING USING A DIGITAL DETECTOR T. J. M. Minkels; C. R. L. P. N. Jeukens; P. Andriessen; A. N. van der Linden; A. J. Dam; H. L. M. van Straaten; E. J. E. Cottaar; C. van Pul

POSTER 014 EFFECTS OF OXYTOCIN ADMINISTRATION DURING PHYSIOLOGICAL-BASED CLAMPING AT PRETERM BIRTH F. Stenning; G. Polglase; M. Kluckow; A. Gill; D. LaRosa; E. Wallace; S. Hooper

POSTER 015 SUBCUTANEOUS EMPHYSEMA IN THE NEONATE Z. Zimová; D. Murgaš; K. Matašová

POSTER 016 LESS COMMON CAUSE OF STRIDOR IN NEWBORNS T. Jurko; A. Jurko jr.; K. Matasova; P. Durdik; D. Murgas; M. Zibolen

POSTER 018 A RARE CASE OF AORTOILIAC THROMBOSIS IN PREMATURE NEONATE A. Mockova; M. Matas; J. Dort; M. Cadova; M. Huml; R. Vondrakova; M. Cerny

POSTER 019 IDENTIFICATION AND SUSCEPTIBILITY PATTERNS OF BACTERIAL ISOLATES FOR NE- ONATES WITH SEPSIS AT KENYATTA NATIONAL HOSPITAL F. Murila; M. Milka; T. Mwanthi

POSTER 020 TWO EXTREMELY LOW BIRTH WEIGHT INFANTS WITH PATENT DUCTUS ARTERIO- SUS MANAGED WITH HYPOXIA INHALATION THERAPY K. Ueda

9 POSTER 021 A STUDY OF RELATIONSHIP BETWEEN FOOD PROTEIN-INDUCED ENTEROCOLITIS SYNDROME AND ALLERGEN-SPECIFIC LYMPHOCYTE STIMULATION TEST IN EARLY NEONATAL K. Tsuchimoto

POSTER 024 BENEFITS OF SKIN-TO-SKIN CONTACT TO PRETERM NEWBORNS H. Pavlyshyn; I. Sarapuk; O. Klishch

POSTER 025 KARTAGENER SYNDROME IN NEONATAL PRACTICE H. Pavlyshyn; V. Slyva; I. Sarapuk; G. Korytskyy

POSTER 026 NEONATAL INTRAVASCULAR CATHETERS: AN AUDIT OF USE AND COMPLICATIONS AT GALWAY UNIVERSITY HOSPITAL (GUH) J. James; A. Binchy; E. Ryan; D. O. Donovan

POSTER 027 PERINEAL GROOVE: PRESENTATION OF TWO CASES V. Mougiou; M. Kollia; E. Nana; R. Sokou; G. Kafalidis; T. Boutsikou; C. H. Salakos N. Iacovidou

POSTER 028 2 CASE REPORTS OF SUBGROUP INCOMPATIBILITY V. Mougiou; M. Kollia; E. Nana; R. Sokou; G. Kafalidis; S. Valsami; T. Boutsikou; N. Iacovidou

POSTER 029 HIGH BLOOD PRESSURE IN 5 TO 8 YEARS OLD CHILDREN BORN VERY PRETERM AND ADEQUATE FOR GESTATIONAL AGE: PRELIMINARY RESULTS I. D’Apremont; R. Moore; H. Poggi; M. Arancibia; D. Andrade; C. Trincado; S. Peredo; C. A. Carvajal; C. E. Fardella; C. Campino; R. Baudrand; H. Garcia; R. X. Sanchez; F. Allende; S. Solari; J. T. Ossa; S. Sifaqui; A. Martínez-Aguayo

POSTER 030 NEONATAL HYPOGLYCEMIC SEIZURES: A CASE REPORT J. Grenha; R. A. Campos; A. Ferreira; D. Soares; M. Mateus; A. L. Leite

10 POSTER 033 OVARIAN CYST IN A TWIN FEMALE NEONATE - A CASE REPORT M. Kollia; Ch. Salakos; M. Eleftheriades; R. Sokou; A. Kontogeorgou; T. Boutsikou; N. Iacovidou

POSTER 034 CONGENITAL DIAPHRAGMATIC HERNIA AND DOUBLE-OUTLET RIGHT VENTRICLE (DORV) IN A NEONATE WITH TRISOMY 18 M. Kollia; R. Sokou; G. Patsouras; P. Panagiotounakou; T. Boutsikou; N. Iacovidou; M. Theodoraki; A. Konstantinidi

POSTER 035 A CASE REPORT OF EPIDIDYMO-ORCHITIS IN A MALE NEONATE R. Sokou; M. Kollia; A. Lampropoulou; I. Moschari; M. Theodoraki; N. Iacovidou; A. Konstantinidi

POSTER 036 FETAL GROWTH RESTRICTION: ONE CONDITION, FOUR DIFFERENT PATHOLOGIES F. Briosa; S. Moeda; S. N. Prado; H. Cavaco; F. Melo

POSTER 037 EARLY NUTRITION AND NEURODEVELOPMENT: IMPLICATIONS OF PERINATAL MORBIDITIES M. Lithoxopoulou; E. Drogouti; E. Goutsiou; P. Karagianni; C. H. R. Tsakalidis; V. Soubasi

POSTER 039 READMISSION PREVALENCE IN VERY LOW BIRTH WEIGHT INFANTS (VLBWI): 2-YEARS FOLLOW UP E. Pittaluga; I. D’Apremont; A. Zamorano; C. Musalem; A. Domínguez; I. Vasquez; P. Mena; J. Smith; M. Díaz; J. P. Cortés; H. Pérez

POSTER 040 CURRENT DATA OF NEONATAL MORTALITY IN CATALONIA FROM 2011 TO 2016 E. Capdevila; R. Porta; M. Ramon; GEN (Grup d’Estudis Neonatals de Catalunya)

POSTER 041 FATAL INTRAUTERIN CAMPYLOBACTER SEPSIS R. Solberg;E. Margas; H. Høyte; W. Daetz; A. P. H. Dyrbekk; N. Grude

11 POSTER 042 PERINATAL OUTCOME IN NEWBORNS OF MOTHERS WITH THYROID DISEASE C. Emmanouil; R. Sokou; A. Kontogeorgou; A. Kampouraki; S. Fousia; T. Boutsikou; N. Iakovidou

POSTER 043 DIETARY HABITS OF EXPECTANT MOTHERS DURING PREGNANCY A. Kontogeorgou; G. Kafalidis; I. Theochari; P. Volaki; R. Sokou; T. Boutsikou; N. Iacovidou

POSTER 045 MATERNAL OMEGA-3 SUPPLEMENTATION PREVENTS HYPEROXIA-INDUCED PULMONARY HYPERTENSION IN THE OFFSPRINGS Y. Zhong; C. Besengez; A. Houeijeh; P. Deruelle; L. Storme

POSTER 046 CERVICAL CHONDROCUTANEOUS REMNANT : A CASE REPORT G. Grivas; C. H. Emmanouil; Z. Iliodromiti; M. Kollia; E. Lampropoulou; T. Boutsikou; N. Iacovidou

POSTER 047 CINICAL CASE PRESENTATION OF INFANTS WITH HAEMOPHILIA A G. Ivanov; D. Subotic; T. Mitrovic

POSTER 051 NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY: A PORTUGUESE EXPERIENCE S. Alves; J. Reis; D. Soares; J. Grenha

POSTER 053 CHARACTERISTICS OF RESPIRATORY MORBIDITIES IN PRETERM SMALL-FOR-GESTATIONAL AGE INFANTS Y. Kawase; K. Ogata; K. Hine; K. Tamaki; N. Mizukaki; H. Arai; H. Yoda

POSTER 054 RUSTY PIPE SYNDROME: A CASE REPORT A. Kontogeorgou, Z. Iliodromiti, M. Kollia, C. Emmanouil, P. Volaki P, R. Sokou, T. Boutsikou, N. Iacovidou

POSTER 055 FACTORS RELATED TO NEONATAL WEIGHT LOSS IN THE FIRST DAYS OF LIFE: EXPE- RIENCE FROM A GREEK BABY-FRIENDLY HOSPITAL A. Kontogeorgou, Z. Iliodromiti, E. Labropoulou, I. Theochari, M. Kollia, P. Volaki, T. Boutsikou, N. Iacovidou

12 The Scientific Committee would like to express their gratitude to the companies for their support

MAJOR SPONSOR

SPONSORS & EXHIBITORS

With the patronage of

13 USEFUL INFO

CONGRESS VENUE Centre des congrès du Palais des Papes Place Palais des Papes 84000 Avignon, France

CONGRESS MATERIAL Participants can collect badge and congress material at the Registration desk located in the Paneterie Hall. Please note that admission to Scientific Session and Social Events is restricted to participants wearing their badge.

CERTIFICATE OF ATTENDANCE The Certificate of Attendance will be available to download on the official website www.neonatalinprovence.eu at the end of the Congress.

POSTER PRESENTATION Poster Presenters are kindly requested to hang their posters on September 6th starting from 17.30 and take them down at the end of the last day (September 9th). Poster numbers will be located on the poster panels, please check the number of your poster on the Scientific Program (POSTER LIST - page 09)

OFFICIAL LANGUAGE English is the official language of the Congress.

ORGANIZING SECRETARIAT

Via Ambrogio Binda, 34 | 20143 Milan - Italy Ph. +39 02 34934404 | Fax +39 02 34934397 [email protected] www.mcascientificevents.eu

14 Fetal and neonatal medicine from basic research to clinical practice

Editor-in-Chief E. Gratacós, Barcelona Fetal Diagnosis and Therapy 2017: Volumes 40, 41 4 issues per volume Language: English : 2.699 Impact factor ISSN 1015–3837 (print) ISSN 1421–9964 (online ) www.karger.com/fdt

Fetal and Neonatal Research Editors-in-Chief

Original Papers 289 Neuro-Imaging Findings in Infants with Congenital Cytomegalovirus Infection: Relation to Trimester of Belfast 241 H.L. Halliday, Prediction of Respiratory Outcome in Extremely Low Infection Gestational Age Infants Oosterom, N.; Nijman, J.; Gunkel, J.; Wolfs, T.F.W.; Parad, R.B.; Davis, J.M. (Boston, Mass.); Lo, J.; Thomas, M.; Groenendaal, F.; Verboon-Maciolek, M.A.; de Vries, L.S. Marlow, N.; Calvert, S.; Peacock, J.L.; Greenough, A. (Utrecht) (London) 297 Infant Arterial Stiffness and Maternal Iron Status in Würzburg 249 Ketamine Attenuates the ACTH Response to Hypoxia C.P. Speer, Pregnancy: A UK Birth Cohort (Baby VIP Study) in Late-Gestation Ovine Fetus Alwan, N.A.; Cade, J.E. (Leeds); McArdle, H.J. (Aberdeen); Chang, E.I.; Wood, C.E. (Gainesville, Fla.) Greenwood, D.C. (Leeds); Hayes, H.E. (Aberdeen); Ciantar, E.; Simpson, N.A.B. (Leeds) 258 Perfusion Index in Preterm Infants during the First 3 Days of Life: Reference Values and Relation with 304 CXCR4 Blockade Attenuates Hyperoxia-Induced Lung Clinical Variables Injury in Neonatal Rats Alderliesten, T.; Lemmers, P.M.A.; Baerts, W.; Groenendaal, Drummond, S.; Ramachandran, S.; Torres, E.; Huang, J.; Neonatology F.; van Bel, F. (Utrecht) Hehre, D.; Suguihara, C.; Young, K.C. (Miami, Fla.) 271 Cost Savings of Human Milk as a Strategy to Reduce the Incidence of Necrotizing Enterocolitis in Very Low Short Communication Birth Weight Infants 2017: Volumes 111, 112 Johnson, T.J.; Patel, A.L.; Bigger, H.R.; Engstrom, J.L.; 266 Phase Changing Material: An Alternative Method for Meier, P.P. (Chicago, Ill.) Cooling Babies with Hypoxic Ischaemic Encephalopathy 277 Lung Deposition of Nebulized Surfactant in Newborn Piglets Thomas, N.; Chakrapani, Y.; Rebekah, G.; Kareti, K.; Devasahayam, S. (Vellore) 4 issues per volume Linner, R.; Perez-de-Sa, V.; Cunha-Goncalves, D. (Lund) 283 Using Measurements of Shunt and Ventilation-to- Perfusion Ratio to Quantify the Severity of Bronchopulmonary Dysplasia Language: English Dassios, T.; Curley, A.; Morley, C.; Ross-Russell, R. (Cambridge) : 2.598 Impact factor ISSN 1661–7800 (print) ISSN 1661–7819 (online ) www.karger.com/neo

Both journals are listed in bibliographic services, including: PubMed/MEDLINE, Web of Science, Google Scholar, Scopus, Embase

Karger – Medical and Scientific Publishers CH–4009 Basel, Switzerland [email protected], f: +41 61 306 12 34

Medical and Scientific Publishers www.karger.com KI17386 Masimo SET®: Advancing Patient Safety Clinical Studies: The Performance of Masimo SET® Measure-through Motion and Low PerfusionTM Pulse Oximetry

CCHD SCREENING Improved Critical Congenital Heart Disease Screening Sensitivity vs. Clinical Assessment Alone When combined with clinical assessment, Masimo SET® 100% improved 93% critical congenital heart disease 80% (CCHD) screening sensitivity to 93% 77% 60%

40%

20%

Zhao et al. Lancet. 2014 Aug 30;384(9945):747-54. Standard Standard Screening Screening +

RETINOPATHY OF PREMATURITY Severe Retinopathy of Prematurity Rate 13% 13% Masimo SET®, coupled with 14% Nellcor N-395 12% Nellcor N-395 Nellcor N-395 changes in clinical practice, 12% led to a significantreduction in 10% 6% rates of severe Retinopathy of 8% 5% 4% Prematurity (ROP) 6% 4%

Castillo et al. Acta Paediatr. 2011 Feb;100(2):188-92. 0% Center A Center B Center A Center B Center A Center B Period I Period II Period III Pre-policy Change Post-policy Change Post-policy Change (With Implementation of (With Implementation of Masimo SET® Masimo SET® in Center B) in Center A and Center B)

PERFORMANCE DURING Performance During Motion and Low Perfusion

50% 43% 50% MOTION AND LOW PERFUSION Nellcor N-600

® 40% 40% Masimo SET had 3% missed true 28% alarms and 5% false alarms versus 30% 30% Nellcor N-600 43% and 28%, respectively, using 20% 20% 3% 5% competitor technology 10% 10%

0% 0% Shah et al. J Clin Anesth. 2012;24(5):385-91. Missed True Alarms False Alarms *Results shown are calculated by combining sensitivity and specificity outcomes Missed True Alarms False Alarms of machine-generated and volunteer-generated motion.

For more information, visit www.masimo.co.uk

For professional use. See instructions for use for full prescribing information, including indications, contraindications, warnings, and precautions. PLCO-001221/PLLT-10553A-0817 © 2017 Masimo. All rights reserved. www.masimo.co.uk

PLLT-10553A, Ad, Masimo SET, A5, EN.indd 1 30/08/17 14:27