DOCSLIB.ORG

S T O W E R S R E P O

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
S T O W E R S R E P O 2 BEMAY THE KEY TO OUR MEMORIES MUCH-MALIGNEDHOW AMYLOIDS FUNCTIONAL AMYLOIDS STOWERS REPORT NEWS AND INSIGHT FROM THE STOWERS INSTITUTE FOR MEDICAL RESEARCH 2020 8 18 23 32 STOWERS REPORT PUBLISHED BY THE STOWERS INSTITUTE FOR MEDICAL RESEARCH 2020 DEPARTMENTS 2 FEATURES 18 THE EXCHANGE 18 A Discussion with Ron Conaway, PhD FUNCTIONAL AMYLOIDS: 20 IN A NUTSHELL A “MAGICAL” PROTEIN STATE Research roundup What’s old is new again How much-maligned amyloids 2 Technologies converge may be the key to our memories Survival of the fit-ish CRISPR knockdown Cavefish provide immunity insight Persistent DNA damage and pregnancy outcomes 23 24 SCIENTIFIC SCIONS Shuonan He: Finding evolutionary biology in the weird Predoc and postdoc awards and fellowships INSTITUTE NEWS 28 THE SPOTLIGHT WHEN SCIENCE MEETS ART Investigator honors and awards An intersection that creates beautiful results 32 8 32 ON CAMPUS Uncommon times require uncommon efforts Welte sails into retirement New leadership team hires Outreach and community engagement efforts expanded COVID-19 claims GSSIMR graduation ceremony Scientists in the making 36 SHARE OUR HOPE 36 Donor contributions 44 BACKSTAGE PASS Wednesday Lecture Series by the numbers NEW OSTEOPOROSIS ADVANCE ROOTED IN STOWERS RESEARCH CONTRIBUTORS: Visit the Stowers Institute at www.stowers.org or find us on Facebook at facebook.com/StowersInstitute Pioneering research helped lay the groundwork or Twitter @ScienceStowers. 15 Editors Scientific illustration for a new approach to treating the disease The Stowers Report is printed on recycled paper. Steve Bellis Mark Miller Kimberly Bland The Stowers Report is published by the Science Communications Department at the Stowers Institute Photography Kristin Kessler for Medical Research with support from the Stowers Foundation. We welcome your input. Please send Mark McDonald comments to [email protected] or contact us at (816) 926-4015. Copy editor Photography and illustration Bonny Moseley Philippe Noguera Web content Design and production Juan Carlos Grover Trozzolo Communications Group Brian Swezy FEATURES By Melissa Fryman Functional amyloids: A “magical” protein state How much-maligned amyloids may be the key to our memories Memory. For the majority of us, it is a constant companion, at times uninvited, and at others, cherished. Sometimes we strain to make and retain a fleeting memory, and at others, a memory seems nothing short of automatically installed, enduring a lifetime in our minds. It’s still mysterious, but the biological process that of Creutzfeldt-Jakob disease, which can arise from a underlies memory persistence is better understood genetic origin, or via transmission from an animal, as now than ever, thanks to researchers from the Si Lab in the human form of “mad cow” disease. at the Stowers Institute. Amyloids are protein aggregates with “In a general sense, memory is the ability of a characteristic structural features and have an system to experience something and then somehow equally bad reputation, being associated with such maintain a signature of that experience, even after the devastating neurodegenerative pathologies as experience has disappeared,” explains Investigator Alzheimer’s and Parkinson’s diseases, as well as and Associate Scientific Director Kausik Si, PhD. In Lewy body dementia. “The central hypothesis is that many biological entities, this capacity is centered in the protein misfolds and forms an amyloid—either the nervous system, and in particular at synapses, a smaller structure of repeating units or a larger which are the connection points between nerve cells. assembly that forms a fibril or fiber—and that it’s a Indeed, it was work done on the sensory-motor toxic entity,” says Si. neural circuit of the sea slug Aplysia californica, by Si 2 and Eric Kandel, MD, at Columbia University nearly 3 twenty years ago, that led to the initial surprising discovery about the molecular requirements for memory maintenance. Their discovery was twofold— an RNA-binding protein called CPEB (cytoplasmic polyadenylation element binding protein) is required for long-term synapse-specific modification, and in order to perform its full function in that capacity, CPEB has to self-assemble to form a functional protein aggregate that can self-renew, effectively acting like a prion. Prions are self-renewing protein aggregates, often amyloid aggregates, that have a deservedly frightful reputation. Perhaps the best-known prion in relation to human health is an infectious prion, the hallmark FEATURES Of their original finding in Aplysia, “that a protein in the A LONG HISTORY OF AMYLOID RESEARCH Together, the emergence of functional amyloids in yeast and bacteria nervous system can aggregate in a very specific situation The term “amyloid” first appeared in the scientific suggested the possibility that amyloids could be non-pathogenic. But nobody and can be a substrate of something that is stable literature in 1838, when it was used to describe the had ever thought that amyloids could be the substrate of memory. yet dynamic such as memory—that’s just completely amylaceous, or starch-like, makeup of plants that stained counter to what people were describing,” Si reflects. blue when exposed to iodine and sulphuric acid. It wasn’t “THEY THOUGHT I WAS OUT OF MY MIND” “Essentially the idea bumped into a hundred years of until 1854 that the term was popularized medically, by “When I thought about it and talked to some people, they thought I studies on protein aggregation and amyloids in the brain the “father of modern pathology” Rudolph Virchow, to was out of my mind. First of all, it’s a prion in the nervous system. that suggested one possibility—and then our finding describe small white deposits in the brain that stained Secondly, if it’s forming an amyloid in the nervous system, it cannot be suggested something radically different.” blue the same way starch did. doing anything good. Thirdly, people thought if amyloids are so stable, Over the years, Si and his team have built a strong “In some sense,” says Si, “from inception, amyloids were how can memory be reversible? After all, memory does change and case for amyloids as a substrate for memory. They associated with the wrong thing—the term was coined to seemingly disappear.” showed that CPEB proteins exist in the brains of mice and describe something that was supposed to be starch-like, but “I was trained as a physical chemist in India,” Si recounts. “I wanted to the fruit flyDrosophila melanogaster, where it is known now we know amyloids are made up of proteins.” switch fields and move to neuroscience, but nobody wanted to take me. So, as Orb2. Importantly, they found that as single units, Orb2 The molecular definition of amyloid emerged from the I actually went to a meeting where I talked to Eric, and I convinced him that binds to specific protein-encoding mRNA messages, work of biophysicist William Astbury, continues Si. “He saw he should let me join his group.” important for memory, located at synapses, acting to that denatured, or unfolded, albumin protein could form fibers “I was interested in a profound observation that Eric’s group had made. They When I thought repress protein production. As an amyloid assembly, by in a particular arrangement—layered zigzag-like structures had discovered if you stop protein synthesis in the synapse, the synapse can still about it and talked to contrast, Orb2 binds those mRNA messages at synapses called stacked b-sheets—with a standard distance between change but it cannot maintain that change over time.” and promotes production of those key synaptic proteins, the stacked layers forming the b-sheets of 4.7 angstroms.” “That finding suggested that the formation of memory and its some people, they leading to a persistent alternation in synaptic transmission A complementary definition of amyloid was derived subsequent maintenance have distinct requirements,” Si continues. To study thought I was out of that allows memory persistence. from the fact that plaques isolated from the brain could how memory sticks around, one must first understand how, and which Using memory assays, they be stained with Thioflavin T and Congo Red dyes. “In the proteins are made in the synapse. my mind. First of all, have shown not only that 1950s and ‘60s, Alan Cohen and colleagues connected “When I started out, I never thought it would lead me to prions and amyloids.” it’s a prion in the self-aggregated Orb2 the two. He isolated dye-stained material from the brain, is required for long- looked at it under an electron microscope, and found that “MAGICAL” PROTEIN STATE nervous system. term memory in some of the material had similar fibrous appearance.” That functional amyloids could exist in the nervous system “provided a very adult fruit flies Researchers then found that amyloid plaques isolated simple solution to one of the most complex biological processes,” says Si. Secondly, if it’s but also that from the brain were resistant to protein-destroying “Our findings suggested that a protein could be used like flipping a switch. forming an amyloid in already-formed enzymes and detergents. “This led to the idea that the By changing the conformation of a protein, the nervous system can encode memory is still amyloid state is an unintended consequence of proteins information on to a stable, yet changeable, physical substrate to achieve the nervous system, dependent being misfolded or unfolded, shortened, or otherwise something seemingly magical, such as memory.” it cannot be doing upon
Load more

Recommended publications
  • Barbara Mcclintock
    Barbara McClintock Lee B. Kass and Paul Chomet Abstract Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983, is best known for her discovery of transposable genetic elements in corn. This chapter provides an overview of many of her key findings, some of which have been outlined and described elsewhere. We also provide a new look at McClintock’s early contributions, based on our readings of her primary publications and documents found in archives. We expect the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. 1 Introduction This chapter is focused on the scientific contributions of Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983 for her discovery of transposable genetic elements in corn. Her enlightening experiments and discoveries have been outlined and described in a number of papers and books, so it is not the aim of this report to detail each step in her scientific career and personal life but rather highlight many of her key findings, then refer the reader to the original reports and more detailed reviews. We hope the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. Barbara McClintock (1902–1992) was born in Hartford Connecticut and raised in Brooklyn, New York (Keller 1983). She received her undergraduate and graduate education at the New York State College of Agriculture at Cornell University. In 1923, McClintock was awarded the B.S.
    [Show full text]
  • Famous Female Scientists
    Appendix B: Scientific Contributions of Thirteen Outstanding Female Scientists Scientific Contributions of Thirteen Outstanding Female Scientists Gerty Cori, with her husband, received international recognition for discovering how glucose converts to glycogen (Cori cycle). This husband and wife team won the 1947 Nobel Prize in physiology or medicine for “discovering the course of the catalytic conversion of glycogen” (mechanism for blood glucose regulation). Cori’s later studies on enzymes and hormones advanced research in diabetes treatment, contributing new understandings that missing enzymes resulted from defective genes. This laid the foundation for future studies of genetic defects in humans. Her research profoundly affected diabetes treatment, allowing physicians to understand how the body stores glucose by converting it predominantly into glycogen, which the body then uses for energy. Despite her significant research, she fought discrimination and nepotism within the Gerty Radnitz Cori scientific community. In 1947, the same year she became the first American woman and the (1896–1954) third worldwide to receive a Nobel Prize in the sciences, she achieved full professor status in biochemistry at Washington University, St. Louis. In 1950, President Harry Truman appointed her to the Board of Directors of the National Science Foundation. Considered the most famous of all women scientists, this Polish researcher “extraordinarie” was the first person (male or female) to win two Nobel Prizes. At age 16, she had already won a gold medal at the Russian lycée in Poland upon completion of her secondary education. In 1891, almost penniless, she began her education at the Sorbonne in Paris and later became the first woman professor to teach there.
    [Show full text]
  • Mothers of Invention: Women in Technology
    Mothers of Invention: Women in Technology n old adage counsels, “Maternity Rideout (AZT), M. Katherine Holloway and is a matter of fact… paternity is Chen Zhao (protease inhibitors), and Diane a matter of opinion.” And indeed, Pennica (tissue plasminogen activator).2 Awhen it comes to people, the evidence of By 1998, women accounted for 10.3 who physically bears the child is visible and percent of all U.S.–origin patents granted undeniable. With the gestation of ideas, annually. Innovation professionals believe this however, lineage is less clear. percentage will continue to increase. A recent The evidence for women’s role in survey of one thousand U.S. researchers technology has been obscured historically. yielded the names of twenty U.S. scientists Only two percent of the fi ve hundred Nobel under the age of forty who have demonstrated Prize Laureates recognized for scientifi c once-in-a-generation insight. Nine of them— achievement are women. As recently as the almost half—are women.3 Jennifer A. Kurtz early 1980s, U.S. Patent and Trademark Offi ce records show that only 2.8 percent of patents Research Fellow, Indiana went to women each year. This participation Business Research Center, rate did not differ much from the 1 percent or Women must Kelley School of Business, so of patents that went to women in the period increasingly pursue Indiana University from 1790 to 1895.1 Young women have had relatively few role science and models to encourage their pursuit of scientifi c and technological adventures. That pattern has technology to ensure begun to change as women are increasingly that the future needs present in all dimensions of the innovation life cycle: knowledge creation, technology transfer, for a skilled U.S.
    [Show full text]
  • Balcomk41251.Pdf (558.9Kb)
    Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr.
    [Show full text]
  • Annotated Bibliography: Women in Physics, Astronomy, and Related Disciplines
    Annotated Bibliography: Women in Physics, Astronomy, and Related Disciplines Abir Am, Pnina and Dorinda Outram, eds. Uneasy Careers and Intimate Lives: Women in Science, 1787-1979. New Brunswick, NJ: Rutgers University Press, 1987. Abir Am and Outram’s volume includes a collection of essays about women in science that highlight the intersection of personal and professional spheres. All of the articles argue that the careers of women scientists are influenced by their family lives and that their family lives are impacted because of their scientific careers. This text is significant in two ways: first, it is one of the earliest examples of scholarship that moves beyond the recovering women in science, but placing them in the context of their home and work environments. Second, it suggests that historians of science can no longer ignore the private lives of their historical subjects. This volume contains four articles relating to women in physics and astronomy: Marilyn Bailey Ogilvie’s “Marital Collaboration: An Approach to Science” (pages 104-125), Sally Gregory Kohlstedt’s “Maria Mitchell and the Advancement of Women in Science” (pages 129-146), Helena M. Pycior’s “Marie Curie’s ‘Anti-Natural Path’: Time Only for Science and Family” (pages 191-215), and Peggy Kidwell’s “Cecelia Payne-Gaposchkin: Astronomy in the Family” (pages 216-238). As a unit, the articles would constitute and interesting lesson on personal and professional influences. Individually, the articles could be incorporated into lessons on a single scientist, offering a new perspective on their activities at work and at home. It complements Pycior, Slack, and Abir Am’s Creative Couples in the Sciences and Lykknes, Opitz, and Van Tiggelen’s For Better of For Worse: Collaborative Couples in the Sciences, which also look at the intersection of the personal and professional.
    [Show full text]
  • Timeline of Genomics (1901–1950)*
    Research Resource Timeline of Genomics (1901{1950)* Year Event and Theoretical Implication/Extension Reference 1901 Hugo de Vries adopts the term MUTATION to de Vries, H. 1901. Die Mutationstheorie. describe sudden, spontaneous, drastic alterations in Veit, Leipzig, Germany. the hereditary material of Oenothera. Thomas Harrison Montgomery studies sper- 1. Montgomery, T.H. 1898. The spermato- matogenesis in various species of Hemiptera and ¯nds genesis in Pentatoma up to the formation that maternal chromosomes only pair with paternal of the spermatid. Zool. Jahrb. 12: 1-88. chromosomes during meiosis. 2. Montgomery, T.H. 1901. A study of the chromosomes of the germ cells of the Metazoa. Trans. Am. Phil. Soc. 20: 154-236. Clarence Ervin McClung postulates that the so- McClung, C.E. 1901. Notes on the acces- called accessory chromosome (now known as the \X" sory chromosome. Anat. Anz. 20: 220- chromosome) is male determining. 226. Hermann Emil Fischer(1902 Nobel Prize Laure- 1. Fischer, E. and Fourneau, E. 1901. UberÄ ate for Chemistry) and Ernest Fourneau report einige Derivate des Glykocolls. Ber. the synthesis of the ¯rst dipeptide, glycylglycine. In Dtsch. Chem. Ges. 34: 2868-2877. 1902 Fischer introduces the term PEPTIDES. 2. Fischer, E. 1907. Syntheses of polypep- tides. XVII. Ber. Dtsch. Chem. Ges. 40: 1754-1767. 1902 Theodor Boveri and Walter Stanborough Sut- 1. Boveri, T. 1902. UberÄ mehrpolige Mi- ton found the chromosome theory of heredity inde- tosen als Mittel zur Analyse des Zellkerns. pendently. Verh. Phys -med. Ges. WÄurzberg NF 35: 67-90. 2. Boveri, T. 1903. UberÄ die Konstitution der chromatischen Kernsubstanz. Verh. Zool.
    [Show full text]
  • Jacsue Kehoe 320
    EDITORIAL ADVISORY COMMITTEE Marina Bentivoglio Larry F. Cahill Stanley Finger Duane E. Haines Louise H. Marshall Thomas A. Woolsey Larry R. Squire (Chairperson) The History of Neuroscience in Autobiography VOLUME 4 Edited by Larry R. Squire ELSEVIER ACADEMIC PRESS Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo This book is printed on acid-free paper. (~ Copyright 9 byThe Society for Neuroscience All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Customer Support" and then "Obtaining Permissions." Academic Press An imprint of Elsevier 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http ://www.academicpress.com Academic Press 84 Theobald's Road, London WC 1X 8RR, UK http://www.academicpress.com Library of Congress Catalog Card Number: 2003 111249 International Standard Book Number: 0-12-660246-8 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 07 08 9 8 7 6 5 4 3 2 1 Contents Per Andersen 2 Mary Bartlett Bunge 40 Jan Bures 74 Jean Pierre G. Changeux 116 William Maxwell (Max) Cowan 144 John E. Dowling 210 Oleh Hornykiewicz 240 Andrew F.
    [Show full text]
  • Genetics Society of America
    Genetics Society of America 1992 Records, Proceedings and Reports Published as supplementary material in GENETICS, Volume 131 Prepared by The Secretary Shirleen Roeder Department of Biology Yale University New Haven, Connecticut s2 BOARDS, COMMITTEES AND REPRESENTATIVES FOR 1992 BOARD OF DIRECTORS John C. Lucchesi, President Karen Artzt A. Dale Kaiser, Vice-president Welcome Bender Shirleen Roeder, Secretary Nina V. Fedoroff Carol S. Newlon, Treasurer Barry S. Ganetzky Leland H. Hartwell, Past President Christine Guthrie John W. Drake, Editor H. Robert Horvitz GENETICSEDITORIAL BOARD John W. Drake, Editor Maureen R. Hanson Sally Lyman Allen Robert K. Herman Karen Artzt Alan G. Hinnebusch Douglas E. Berg Richard R. Hudson David Botstein Nancy A. Jenkins John E. Boynton Mark Johnston Anthony H. D. Brown Elizabeth Jones Benjamin Burr Cathy C. Laurie Marian Carlson Wen-Hsiung Li Deborah Charlesworth Trudy F. C. Mackay Peter Cherbas Patricia J. Pukkila Arthur Chovnick Trudi Schiipbach Andrew G. Clark William F. Sheridan Thomas W. Cline Michael J. Simmons Rowland H. Davis Montgomery Slatkin Robin E. Denell Gerald R. Smith Norman R. Drinkwater Steven D. Tanksley Walter F. Eanes Elizabeth Thompson Victoria G. Finnerty Bruce S. Weir Margaret T. Fuller Fred Winston Roger E. Ganschow ADMINISTRATIVE OFFICE Elaine Strass, Executive Director Barbara Abbott, Publicat~nsAssistant/ASHG Membership Coordinator Sharon Adler, Accounting Assistant Judy Ashton, Oflce Coordinator Candis Galkin, Accounting Assistant Gloria Garber, Membership and Meetings Assistant Karen Gould, Comptroller/Manager of Administration Margot Kiley, GSA Membership Coordinator Krista Koziol, Publications Manager Anne Marie Langevin, GSA Meetings Manager Marsha Ryan, ASHG Meetings Manager Jane Salomon, ASHG Special Projects Manager COMMITTEES Leland H.
    [Show full text]
  • Commentary on the Nobel Prize That Has Been Granted in Medicine-Physiology, Chemistry and Physics to Noteable Female Scientists
    Gaceta Médica de México. 2015;151 Contents available at PubMed www.anmm.org.mx PERMANYER Gac Med Mex. 2015;151:264-8 www.permanyer.com GACETA MÉDICA DE MÉXICO HISTORY AND PHILOSOPHY OF MEDICINE Commentary on the Nobel Prize that has been granted in Medicine-Physiology, Chemistry and Physics to noteable female scientists Arturo Zárate*, Leticia Manuel Apolinar, Renata Saucedo and Lourdes Basurto © Permanyer Publications 2015 .rehsilbup eht fo noissimrep nettirw roirp eht tuohtiw gniypocotohp ro decudorper eb yam noitacilbup siht fo trap oN trap fo siht noitacilbup yam eb decudorper ro Endocrinology, Diabetesgniypocotohp and Metabolism Researchtuohtiw eht Unit, Centro Médicoroirp Nacional, Institutonettirw Mexicano del Seguronoissimrep Social (IMSS),fo México,eht D.F., México .rehsilbup Abstract The Nobel Prize was established by Alfred Nobel in 1901 to award people who have made outstanding achievements in physics, chemistry and medicine. So far, from 852 laureates, 45 have been female. Marie Curie was the first woman to receive the Nobel Prize in 1903 for physics and eight years later also for chemistry. It is remarkable that her daughter Irene and her husband also received the Nobel Prize for chemistry in 1935. Other two married couples, Cori and Moser, have also been awarded the Nobel Prize. The present commentary attempts to show the female participation in the progress of scientific activities. (Gac Med Mex. 2015;151:264-8) Corresponding author: Arturo Zárate, [email protected] KEY WORDS: Nobel Prize. Nobel Prize winning women. Female scientists. to be awarded every year. Since 1901, this prize has ntroduction I been awarded in the areas of physics, chemistry, phys- iology and medicine to 852 persons, out of which 45 In the year of 2014, the Medicine Nobel Prize was have been women1.
    [Show full text]
  • Lasker Interactive Research Nom'18.Indd
    THE 2018 LASKER MEDICAL RESEARCH AWARDS Nomination Packet albert and mary lasker foundation November 1, 2017 Greetings: On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards. Since 1945, the Lasker Awards have recognized the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease. The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement. The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged. Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination. The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org. Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the Nobel Prize, including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org. A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will
    [Show full text]
  • Fear of Failure, Fear of Success*
    OpenStax-CNX module: m36864 1 Fear of Failure, Fear of Success* Rice ADVANCE This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 Abstract Keynote presentation presented by Mikki Hebl at the 2010 NSF ADVANCE Workshop: Negotiating the Ideal Faculty Position, A Workshop for Underrepresented PhDs and Postdocs in Science, Engineering and Psychology September 19-21, 2010 1 http://www.phds.org/ Career Information (591) Required Reading (158) Finding Employment (908) The Big Picture (464) Graduate School (573) Postdocs (427) Undergraduate Research (24) 2 Suggested Reading Silvia, P. (2007). How to Write a lot: A Practical Guide to Productive Academic Writing. American Psychological Association Darley, J. M., Zanna, M. P., & Roediger III, H. L. (2003). The compleat academic: A career guide. 2nd edition. Washington, D.C.: American Psychological Association. Psyc 660: Professional Development - survival skills are discussed, including the ability to communicate eectively, to nd and keep a job, to secure funding, publish, teach, and behave responsibly. *Version 1.1: Feb 8, 2011 5:51 pm -0600 http://creativecommons.org/licenses/by/3.0/ http://cnx.org/content/m36864/1.1/ OpenStax-CNX module: m36864 2 Figure 1 3 Why I love my job in academia Figure 2 • Inquiry • Mentoring Students • Bright Colleagues • Beautiful Workplace • Eventual Job Security • Absence of Monotonity • Flexibility http://cnx.org/content/m36864/1.1/ OpenStax-CNX module: m36864 3 4 Top Two Reasons that Other People Love Academia Figure 3 Vacations Summer 5 Will you also love academia? • What are your fears and concerns about this career? • Please indicate on the note cards 2-3 things that you fear about a career in academia.
    [Show full text]
  • Nobel Laureates in Physiology Or Medicine
    All Nobel Laureates in Physiology or Medicine 1901 Emil A. von Behring Germany ”for his work on serum therapy, especially its application against diphtheria, by which he has opened a new road in the domain of medical science and thereby placed in the hands of the physician a victorious weapon against illness and deaths” 1902 Sir Ronald Ross Great Britain ”for his work on malaria, by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it” 1903 Niels R. Finsen Denmark ”in recognition of his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation, whereby he has opened a new avenue for medical science” 1904 Ivan P. Pavlov Russia ”in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged” 1905 Robert Koch Germany ”for his investigations and discoveries in relation to tuberculosis” 1906 Camillo Golgi Italy "in recognition of their work on the structure of the nervous system" Santiago Ramon y Cajal Spain 1907 Charles L. A. Laveran France "in recognition of his work on the role played by protozoa in causing diseases" 1908 Paul Ehrlich Germany "in recognition of their work on immunity" Elie Metchniko France 1909 Emil Theodor Kocher Switzerland "for his work on the physiology, pathology and surgery of the thyroid gland" 1910 Albrecht Kossel Germany "in recognition of the contributions to our knowledge of cell chemistry made through his work on proteins, including the nucleic substances" 1911 Allvar Gullstrand Sweden "for his work on the dioptrics of the eye" 1912 Alexis Carrel France "in recognition of his work on vascular suture and the transplantation of blood vessels and organs" 1913 Charles R.
    [Show full text]