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:Ataxia: EssentialEssential FactsFacts forfor PatientsPatients

• Neurodegenerative diseases where the loses nerve cells, What Is It? such as (MSA), The word Ataxia comes from the Greek and means “without (SCA), etc. order.” Ataxia refers to disorganized, clumsy movements and difficulties with . Coordination of movement requires • Hereditary (inherited or genetic) causes multiple parts of the to work together and if one ow is it iagnosed area is damaged ataxia may occur. Your doctor will examine you H D ? To diagnose ataxia, a doctor needs to ask about your clinical to see if he/she can determine if ataxia is caused by dysfunction history, including a thorough family history. You will also have a of the brain, spinal cord, or nerves. The most common area of the detailed neurological examination and, if necessary, diagnostic brain responsible for ataxia is the . tests that may include: What Are the Symptoms of Ataxia? • Imaging studies: a brain scan using computerized tomography • Difficulty with balance when standing (CT) or magnetic resonance imaging (MRI) and/or a spine MRI • Difficulties with walking which may include: • Tests for blood, urine and spinal fluid samples - Walking with your feet spread wide apart • Tests on blood pressure and urinary function - Swaying or to one side or the other • Cardiac examination - Inability to walk in a straight line - Falls because of unsteadiness • Nerve conduction studies and electromyography (ENG/EMG) • Uncoordinated, clumsy hand movements • Cognitive or neuropsychological evaluation • Shaking () that usually gets worse when reaching for a • Eye evaluation target. It can affect arms, legs, head or even the whole body. • Blood tests for genetic/hereditary • Problems with , mainly slurring Is There a Treatment? • Problems with eye movements that can cause double or blurred Treating ataxia depends on the cause. If the ataxia is due to drugs vision or toxins, stopping the exposure to that agent may improve the • Dizziness ataxia. Treatment may be possible for certain vitamin deficiency, tumor, autoimmune issues or metabolic disease. Some genetic What Are the Causes? ataxias may have a specific vitamin or drug treatment. Ataxia is a neurological sign and not a disease. There are many When there is no specific treatment available, physical, possible causes including: occupational and speech therapy may help to improve the • Brain damage from tumors, , head trauma, infection, etc. function and quality of life of patients with ataxia. • Vitamin deficiencies such as low levels of vitamin B1, B12 or E • Exposure to certain drugs or toxins such as , carbamazepine, , sedative drugs, some antibiotics, , amiodarone and • Autoimmune issues such as , an immune response against a tumor, brain blood vessel inflammation or celiac disease • Metabolic diseases such as thyroid gland dysfunction or low blood sugar levels

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