american academy of arts & sciences
summer 2018 www.amacad.org Bulletin vol. lxxi, no. 4
A Celebration of the Arts and Sciences
A Philosophical Approach On Sex and Death to Anger and Fear Barbara J. Meyer Martha C. Nussbaum
Morton L. Mandel Public Lecture How to Make Citizens Eric Liu
ALSO: Songs of Love and Death–Jessie Ann Owens Combatting Corruption: Dædalus Examines How to Halt Political and Corporate Graft Remembering Francis M. Bator, Steven Marcus, and Jerrold Meinwald Upcoming Events
SEPTEMBER 6th 6th Sanders Theatre Harvard University Emory University Cambridge, MA Atlanta, GA Induction Ceremony Morton L. Mandel Public Lecture The Study of Writing by African American Women 7th Featuring: Frances Smith Foster (Emory University), American Academy Beverly Guy Sheftall (Spelman College), Pellom Cambridge, MA McDaniels III (Emory University), Michelle M. Annual David M. Rubenstein Lecture Wright (Emory University). Welcome by Dwight A. McBride (Emory University) 15th 12th American Academy Cambridge, MA American Academy in collaboration with the Massachusetts Historical Society Cambridge, MA Social Reception “All Legislative Powers . . .” Article 1 of the U.S. Constitution, Then and Now hosted by the Boston-Cambridge Planning Committee Featuring: Jack Rakove (Stanford University) and Margaret Marshall (Choate Hall & Stewart llp; 20th formerly, Massachusetts Supreme Judicial Court) University of Pennsylvania Philadelphia, PA 16th Understanding Public Attitudes and Engagement with Science American Academy Roundtable Discussion hosted by the Philadelphia Cambridge, MA Planning Committee The Challenge for Business and Society: From Risk to Reward Featuring: Stanley Litow (Columbia University; Duke 28th University; ibm; ibm Foundation) Stanford University Stanford, CA 30th A Discussion about Technology and the Self American Academy Featuring Peter Galison (Harvard University) Cambridge, MA 2018 Distinguished Morton L. Mandel Annual Public Lecture OCTOBER The Implications of the 2020 Census 5th–7th Featuring: Kenneth Prewitt (Columbia University) Cambridge, MA Induction Weekend
5th mit Samberg Conference Center Cambridge, MA A Celebration of the Arts and Humanities Featuring: Tania León (Brooklyn College and The Graduate Center, City University of New York), Viet Thanh Nguyen (University of Southern California), Richard J. Powell (Duke University), Jacqueline Stewart (University of Chicago), Damian Woetzel (The Juilliard School)
For updates and additions to the calendar, visit www.amacad.org. From the President
he Academy’s larger projects, like the Commission on the Future of Undergraduate T Education and The Public Face of Science, are designed to help influence the intellec- tual life of the country–by providing new ideas, recommending new ways to address chal- lenges, and calling attention to new knowledge. Often, these projects produce written doc- uments–reports, occasional papers, or issues of Dædalus–that express the findings of their multidisciplinary committees. Increasingly, these projects also rely on the extraordinary convening capacity of the Academy–its ability to bring together experts from a range of fields and disciplines–to extend the influence of their work. Many of our projects continue long after their planned activities have concluded, by facilitating new collaborative efforts and establishing partnerships with the organizations and institutions most likely to benefit from our work. Jonathan F. Fanton Two projects, in particular, have been very successful in establishing these partnerships. The Academy’s project on Civil Wars, Violence, and International Responses produced two volumes of Dædalus (Fall 2017 and Winter 2018) that explored the current state of civil wars around the world, the threats associated with intrastate violence and state disorder, and the policy options for the United States and the international community to respond to widespread violence and mitigate the global risks associated with it. The project hosted conferences, private briefings, public events, and workshops with un rep- resentatives, government officials, academics, policy-makers, and practitioners in the United States and internationally. Following the release of the second volume of Dædalus, selected proj- ect participants met with military and civilian personnel from the office of the U.S. Secretary of Defense, the office of the Chairman of the Joint Chiefs of Staff, and other Department of De- fense offices to discuss the U.S. evolving strategy on counter-terrorism, including the role of in- ternational humanitarian law in counter-terrorism practices. Several project participants also met with members of the National Security Council. The group participated in a briefing with more than tennsc staff and region-specific directors. The project experts offered short- and long-term recommendations for preventing, mitigating, and helping countries recover from civil violence. Along with collaborating with domestic institutions, the project team also engaged with in- ternational organizations, including the United Nations Department of Peacekeeping Opera- tions, the United Nations Department of Political Affairs, and the office of the United Nations High Commissioner for Refugees. The meetings focused on how best to improve the internal capacities of the un to respond to widespread violence around the world. The project’s experts discussed how emerging and evolving technologies–when duly regulated–could help enhance un capacities to intervene in conflicts, protect civilians, and monitor more accurately displace- ments and dislocations. Similar to the Civil Wars project, the Commission on Language Learning produced several publications, including a final report onAmerica’s Languages: Investing in Language Education for the 21st Century. The report has helped to shape new legislative proposals at the federal level, in- cluding the World Languages Advancement and Readiness Act, which, if passed, would fund a grant program within the U.S. Department of Defense to foster innovative language instruc- tion in K-12 education. It has also inspired new conversations about global education curricula from the president
at schools and colleges like Northwestern University and Indiana University, and a range of out- reach activities around the country. Since the report was released in 2017, the Academy has convened a working group to coor- dinate additional follow-up efforts. The America’s Languages Working Group includes Com- mission members as well as other representatives from the language profession, academia, government, business, ngos, and heritage and indigenous communities. On May 30, 2018, it published its first joint statement, “Bridging America’s Language Gap,” a call-to-action urging increased support for language education and improved access for students at every level. Thirty- eight individual business, government, and cultural leaders and over 150 organizations, includ- ing academic associations, businesses, colleges and universities, cultural and international orga- nizations, language education associations, professional associations, school systems, and state humanities councils, have signed the call-to-action. The Academy will continue to add endorse- ments over time. The Working Group plans to use the call-to-action and a future online resource highlighting successful practices to help advance the Language Commission’s recommenda- tions around the country. The project on Civil Wars, Violence, and International Responses and the Language Commis- sion were both initiated by committees of distinguished Members and experts who worked to- gether to formulate practical recommendations. Once these committees completed their work, the projects shifted focus to the people and organizations in the best position to advance their recommendations, fostering collaboration, building consensus, and encouraging further activi- ty. This is an important strategy for many Academy projects, and one that the Academy has pur- sued more frequently in recent years to great success. To help identify potential partners and receptive audiences for our work, the Academy–with generous support from Morton Mandel and the Jack, Joseph & Morton Mandel Foundation– has also created a new position: Director of Strategic Implementation. Our first director, Peter Robinson, is already working with Members and others to ensure that our projects have their intended effects. We welcome your thoughts and suggestions about other ways to enhance the impact of our work. Contents
Projects and Publications
4 Combating Corruption: Dædalus Examines How to Halt Political & Corporate Graft 9 New Humanities Indicators on Career Outcomes for Recipients of Advanced Degrees
Presentations
12 Don M. Randel Award for Humanistic Studies: Acceptance Remarks A Philosophical Approach to Anger and Fear Martha C. Nussbaum; Introduction by Paul Guyer 16 Francis Amory Prize Acceptance Remarks On Sex and Death Barbara J. Meyer; Introduction by David C. Page 25 Songs of Love and Death: I madrigali a cinque voci (Venice, 1542) by Cipriano de Rore (1515/16–1565) Jessie Ann Owens; Introduction by Jane A. Bernstein 33 Morton L. Mandel Public Lecture How to Make Citizens Eric Liu
Update on Members
41 In Memoriam: Francis M. Bator 43 In Memoriam: Steven Marcus 44 In Memoriam: Jerrold Meinwald 46 Noteworthy
Bulletin of the American Academy of Arts & Sciences, Summer 2018 3 projects and publications
Combating Corruption: New Daedalus Issue Examines How to Halt Political & Corporate Graft orruption can be ruinous, destroying nations, institutions, communities, individuals, the environment, and the very C notion of public trust. Corruption self-reinforces, respects no law or border, and reproduces like disease. Most im- portant, though, is that corruption is a systemic malady. It originates from the top and permeates downward; misconduct at one level seemingly authorizes it at the next. In his introduction to the Summer 2018 issue of Dædalus, guest editor and Academy Member Robert I. Rotberg (Harvard Kennedy School) asserts that “integrity or its absence . . . seeps into the collective societal consciousness: either to make corruption an ongoing social practice and an essential (even if de jure forbidden) component of a governing political culture; or more rarely, to accomplish the reverse, creating legal and nor- mative barriers to wholesale approval of corrupt practices.” Corruption is so pervasive that it accounts for a loss of an es- timated $1 trillion annually–roughly 2 percent of global gdp–and disproportionately harms the countries and people that can least afford it. Yet there is room for optimism: corruption is not inevitable, and it is not unstoppable; the battle against pervasive and engrained corruption can be won.
“Anticorruption: How to Beat Back Political & Corporate Graft” explores the nature of modern global corruption–and how to defeat it. Highlight- ing examples from the United States, Brazil, Cana- da, China, Hong Kong, Nigeria, and Singapore, the authors in this issue–including both academics and law-makers–offer innovative, strategic, and practi- cal recommendations to target public and private cor- ruption. The authors recognize the enormity of their challenge, but focus on what is possible and what must be done: anticorruption successes are hard-won and difficult to sustain, but are essential for economic and social growth and political accountability.
Inside the Issue
Corruption is not only persistent and pervasive, but it is also difficult to solve, despite the multitude of Demonstrators protesting against South African President Jacob Zuma and calling anticorruption campaigns across the globe. Indeed, for his resignation hold placards and shout slogans outside the Gupta Family com- most countries have failed to move the needle on pound in Johannesburg on April 7, 2017. © 2018 by Gulshan Khan/AFP/Getty Images. corruption over the last few decades. Yet Robert I. Rotberg (Harvard Kennedy School) begins the issue optimistically: rethinks international development’s standard tools for reducing the anticorruption effort is well-informed and there is a great deal corruption. While aid conditioned on good governance seemed of research on how countries have successfully beaten back corrup- like a potentially useful component of the anticorruption toolkit tion, including by establishing anticorruption agencies, increasing from the perspective of international development agencies, recent transparency, and creating merit-based bureaucracies. Although decades have shown that most of the top recipients of condition- corruption is a tenacious problem, Rotberg notes that this collec- al international aid have not progressed on indicators of corrup- tion of essays highlights a variety of anticorruption strategies– tion. This disappointment propels Mungiu-Pippidi to offer a new both successful and unsuccessful–and calls for innovative ap- road map toward establishing standards of “ethical universalism” proaches to refine best practices. in governance, which includes diagnosing the norm of resource al- In “Seven Steps to Control of Corruption: The Road Map,” location in a particular country and identifying the human agen- Alina Mungiu-Pippidi (Hertie School of Governance, Germany) cy with the most to gain from spearheading anticorruption efforts.
4 Bulletin of the American Academy of Arts & Sciences, Summer 2018 combating corruption
In “Fighting Systemic Corruption: The Indirect Strategy,” Bo (American University) argues that anticorruption policies fail to Rothstein (University of Gothenburg, Sweden) highlights the need translate to lasting success unless they are accompanied by a shift to rethink unsuccessful “best practices” in fighting corruption. The toward lasting accountability in state institutions. He identifies the principal-agent theory–based on the idea that corruption can be need to standardize the process of institutionalization, presenting remedied if the honest “principal” changes the incentives for its an “accountability equation”: namely, accountability is the out- corrupt “agents,” who will find that it suits their own best interest come of transparency, oversight, and sanction, moderated by the to avoid corrupt actions–is often used as a model for explaining degree of institutional effectiveness, and tempered by the degree of corruption. But it does not work well as a guideline for reducing political dominance. This equation can be used to identify “trans- corruption, as it depends on the will of an uncorrupted leader at the top of states or organizations, a leader who does not ex- Corruption is so pervasive that it accounts for a ist in practice. Rather, Rothstein suggests loss of an estimated $1 trillion annually – roughly thinking about corruption as a “collective action problem” or “social trap”: name- 2 percent of global GDP – and disproportionately ly, the idea that people are willing to do harms the countries and people that can least afford the right thing as long as they believe oth- ers will do the same. The reverse also ap- it. Yet there is room for optimism: the battle against plies: when corruption is understood as pervasive and engrained corruption can be won. a widespread, even sanctioned, phenom- enon, people are more likely to engage with it. Thus, Rothstein finds promise in military theorist Basil Lid- parency bottlenecks” and areas for institutional improvement in a dell Hart’s “indirect attack” approach: rather than a direct attack number of sectors and contexts. He emphasizes the importance of against corrupt leaders, an indirect attack (such as universal public generating societal trust and conducting ongoing, iterative evalua- education) finds and attacks the “Achilles heel” of corruption, bet- tions of viable solutions. ter upsetting the social equilibrium that allows corrupt actors to act In “Combating Corruption in the Twenty-First Century: New Ap- with impunity. proaches,” Paul M. Heywood (University of Nottingham, United In “Reforming Reform: Revising the Anticorruption Playbook,” Kingdom) identifies the lack of substantial progress on corruption Michael Johnston (Colgate University; International Anti-Cor- in recent decades and questions anticorruption literature’s tenden- ruption Academy) takes a bird’s-eye view of the last thirty years of cy to generalize, pointing instead to the fact that new technologies, international anticorruption efforts, observing that although in- forms of political organization, and economic trends have opened creased attention to corruption can only be a positive sign, standard up opportunities for corruption that must be treated as unique and practices for fighting corruption have yielded lackluster results. He context-dependent. Heywood argues that, rather than focusing on questions a number of common suppositions espoused by anticor- unrealistic aspirations of defeating or eliminating corruption, an- ruption experts, including claims that increasing transparency and ticorruption advocates must focus instead on promoting integrity: creating large anticorruption agencies will always ameliorate the that is, values that encourage noncorrupt behavior. However, he problem. Johnston argues that corruption is best combated indi- notes that simply ensuring officials do not act corruptly is insuf- rectly, by developing relationships of accountability between citi- ficient: “the absence of corruption does not imply the presence of zens and the government, such as through education and civil so- integrity.” Thus, in order to build and promote a formal framework ciety. Johnston thus advocates for what he calls “deep democrati- based on integrity, he calls for a better conceptual understanding of zation”: a holistic development of citizen engagement in which integrity in public life and its relationship to corruption. “citizens have a voice . . . and can defend themselves against official In “Corruption & Purity,” Susan Rose-Ackerman (Yale Univer- abuses.” Indeed, he opines, “integrating citizens and their needs sity) explores corruption through a legal framework. Troubled by and wishes into governing lends new meaning to the notion of in- the prevalence of definitions that frame any violation of a person’s tegrity, evoking honesty and transparency but also wholeness.” ideals as corruption, Rose-Ackerman defines corruption as any cir- In “Getting to Accountability: A Framework for Planning & cumstance in which a steward of a public program operates in his Implementing Anticorruption Strategies,” Matthew M. Taylor or her own private interest in such a way that undermines the goals
Bulletin of the American Academy of Arts & Sciences, Summer 2018 5 projects and publications
es on opportunities for new antimonopoly and campaign finance laws. As she concludes, the problem is not with the existence of the corporation, the “problem is with concentrated power: a handful of actors who are sui generis; so large and powerful they can bend public power. The modern anticorruption movement chooses not to address these large actors, using formalism or legalism as an ex- cuse, at all of our peril.” In “Corruption & Illicit Trade,” Louise I. Shelley (George Ma- son University) details how illicit trade–including of drugs, en- dangered species, and people–represents a significant sector of the global economy and compromises the integrity of financial, ecological, and political systems. These transactions would be im- possible without corrupt actors, from border officials to high-level politicians to entrepreneurs on the Darknet. The relationship be- tween corruption and illegal trade is mutually enforcing. Howev- er, while the phenomenon she describes is “decidedly transnation- al . . . most strategies and legal frameworks to combat corruption are state-based and thus are woefully inadequate to the task.” She thus identifies potential strategies for disrupting this cycle, includ- ing increasing transparency in international financial institutions and supply chains. In “The World Needs an International Anti-Corruption Court,” Mark L. Wolf (United States District Court for the State of Massa- chusetts) argues that part of the difficulty in addressing corruption lies in the fact that corrupt high-level leaders often do not have the incentive to hold themselves or their colleagues legally responsible Demonstrators protest along Paulista Avenue in São Paulo, Brazil, on for malfeasance. This problem also arose in another context: that December 4, 2016, against corruption and in support of the Lava Jato of massive human rights violations perpetrated or sanctioned by anticorruption operation. © 2018 by Miguel Schincariol/AFP/Getty Im- state-level leaders. In response, we created the International Crim- ages. inal Court, which has successfully prosecuted human rights cases following genocides and civil wars. Judge Wolf advocates for an of the program. From this definition, she analyzes clear-cut cases International Anti-Corruption Court (iacc) and argues that cer- of corruption, including petty corruption (bribery of officials) and tain incentives, such as making iacc membership a condition of election fraud, which can be remedied by changing certain private World Trade Organization membership and a requirement of be- actors’ relationships to the state; as well as more ambiguous cases ing a party to the United Nations Convention against Corruption such as campaign finance, for which more nuanced policy solutions and to major trade agreements, would improve participation in the are necessary. court. Such a court, Wolf suggests, would make strides in repatriat- In “The Problem of Monopolies & Corporate Public Corrup- ing stolen wealth and making corruption an exception, rather than tion,” Zephyr Teachout (Fordham University School of Law) turns the rule, in governance. the focus away from corrupt elected or appointed officials and to- In “Preventing Systemic Corruption in Brazil,” Sérgio Fernan- ward private actors who selfishly exercise public power. She argues do Moro (Thirteenth Federal Criminal Court of Brazil) details the that when corporations exercise public power selfishly, putting ongoing anticorruption investigation known as Operação Lava Jato profit above public interest, they are engaging in corrupt behavior. (“Operation Car Wash”) from the perspective of the federal judge Her approach is prophylactic, centered not on targeting monopo- overseeing its prosecution. Beginning as an isolated instance of cor- lies like Google, but on preventing future consolidation of corpo- ruption in the Brazilian oil company Petrobras, Lava Jato has grown rate power and private corruption. As a remedy, Teachout focus- into the largest anticorruption effort in Brazilian history, leading to,
6 Bulletin of the American Academy of Arts & Sciences, Summer 2018 combating corruption
so far, more than sixty criminal cases brought against nearly three where, often attracts little prosecutorial response due to the wide- hundred defendants in Brazilian federal courts. Judge Moro shows spread practice of granting immunity to current and former office- how independent investigators and judges can follow due process holders.” However, Bracking identifies several reasons to hope that to convict high-ranking corrupt politicians and business executives the situation can improve: South Africa still possesses a relatively who were previously thought to be untouchable. Indeed, “the Lava independent private sector, media, and political opposition, all of Jato cases . . . represent a clear break with a past of impunity and which can close ranks to refuse to cooperate with corrupt cadres. with tolerance for systemic corruption” in Brazil. Moro highlights In “Strategies for Advancing Anticorruption Reform in Nigeria,” the fundamental parts of the investigation to offer lessons for anti- Rotimi T. Suberu (Bennington College) details how Nigeria’s se- corruption efforts elsewhere. vere political corruption has led to massive misuse of public funds; In “Corruption & State Capture: What Can Citizens Do?” Sarah eroded public services such as education, water supply, and trans- Bracking (King’s College London) offers an account of the impuni- portation infrastructure; and contributed to the rise of terrorism ty with which South Africa’s leading cadre, led by former President from groups such as Boko Haram. And while Nigerian President Jacob Zuma, came to “capture” key sites of control in the country’s Muhammadu Buhari has promised a comprehensive disruption of government and corporate sector and prey upon public coffers. corruption, he has not delivered. Suberu offers an in-depth anal- Bracking details how Zuma’s clique defended its corrupt practices ysis of the institutional failings, policy gaps, and structural chal- by taking advantage of lax international finance laws, capitalizing lenges that created an environment for corruption to thrive, while on the racial tensions of a postapartheid nation, and intimidating also detailing some of the less-publicized successes of the Nigerian state workers and citizens alike with violence. Unfortunately, “the anticorruption movement. Ultimately, he suggests five innovative Machiavellian behavior of political elites in modern Africa, as else- solutions: 1) creating apolitical anticorruption and oversight agen-
“Anticorruption: How to Beat Back Political & Corporate Graft” Summer 2018 issue of Dædalus
Accomplishing Anticorruption: Propositions & Methods by Robert I. The Problem of Monopolies & Corporate Public Corruption by Zephyr Rotberg (Harvard Kennedy School) Teachout (Fordham University School of Law) Seven Steps to Control of Corruption: The Road Map by Alina Corruption & Illicit Trade by Louise I. Shelley (George Mason Mungiu-Pippidi (Hertie School of Governance, Germany) University) Fighting Systemic Corruption: The Indirect Strategy by Bo Rothstein The World Needs an International Anti-Corruption Court by Mark L. (University of Gothenburg, Sweden) Wolf (United States District Court for the District of Massa- chusetts) Reforming Reform: Revising the Anticorruption Playbook by Michael Johnston (Colgate University; International Anti-Corruption Preventing Systemic Corruption in Brazil by Sérgio Fernando Moro Academy) (Thirteenth Federal Criminal Court of Curitiba, Brazil) Getting to Accountability: A Framework for Planning & Implement- Corruption & State Capture: What Can Citizens Do? by Sarah ing Anticorruption Strategies by Matthew M. Taylor (American Bracking (King’s College London) University) Strategies for Advancing Anticorruption Reform in Nigeria by Rotimi Combating Corruption in the Twenty-First Century: New Approaches T. Suberu (Bennington College) by Paul M. Heywood (University of Nottingham, United Combating Corruption in Asian Countries: Learning from Success & Kingdom) Failure by Jon S.T. Quah (National University of Singapore) Corruption & Purity by Susan Rose-Ackerman (Yale University) How Not to Fight Corruption: Lessons from China by Minxin Pei (Claremont McKenna College)
Bulletin of the American Academy of Arts & Sciences, Summer 2018 7 projects and publications
As Zephyr Teachout notes, the problem is not with the existence of the corporation, the “problem is with concentrated power: a handful of actors who are sui generis; so large and powerful they can bend public power. The modern anticorruption movement chooses not to address these large actors, using formalism or legalism as an excuse, at all of our peril.” cies; 2) curbing the discretionary power of political executives; 3) peting anticorruption agencies; and 4) ensure that Type A anticor- restructuring the Nigerian system of unconditional federal reve- ruption agencies function as independent watchdogs. nue distribution into a conditional grants scheme; 4) strengthen- In “How Not to Fight Corruption: Lessons from China,” Minxin ing transparency laws; and 5) mobilizing extensive public partici- Pei (Claremont McKenna College) uses China to explain how not to pation in constitutional change. fight corruption. Judging by the numbers, General Secretary Xi Jin- In “Combating Corruption in Asian Countries: Learning from ping’s ferocious anticorruption campaign can only impress: From Success & Failure,” Jon S.T. Quah (National University of Singa- late 2012 to July 2017, the drive has investigated and sanctioned or pore) highlights the successful anticorruption campaigns of Singa- imprisoned tens of thousands of Communist Party and military pore and Hong Kong, despite widespread corruption among Asian and police officials, including vice ministers, generals, and deputy countries. Quah mines lessons from these stories, pointing to polit- provincial governors, and other high-ranking officials. Yet this en- ical will as a major factor in the effectiveness of those countries’ an- forcement-centered strategy, Pei argues, is fundamentally a politi- ticorruption agencies (as indicated by public funding and staff-pop- cal purge of Xi’s rivals, and is neither sustainable nor durable. Pei ulation ratios in those countries). He also points to the need to ad- recommends that China rebalance its enforcement drive with cor- dress context-specific root causes of corruption rather than curbing ruption prevention, passing mandatory rules of wealth disclosure corruption in public displays; and to the critical importance of in- and spending transparency, and relinquishing Party control of the dependence on the part of anticorruption agencies. He concludes economy. Although Pei believes that the Chinese Communist Par- with four lessons for policy-makers: 1) political will is essential for ty will not tolerate the political risks of such reforms, he creates a success in combating corruption; 2) policy-makers must initiate ap- model for states that do possess the political will to build a success- propriate reforms to tackle corruption by addressing its root caus- ful long-term anticorruption program. es; 3) policy-makers much establish Type A anticorruption agencies Academy Members may access an electronic copy of this Dædalus (agencies tasked only with fighting corruption) rather than relying issue by logging into the Academy’s website and visiting the Mem- on Type B anticorruption agencies (agencies tasked with multiple bers page. For more information about Dædalus, please visit http:// responsibilities, including fighting corruption) or multiple, com- www.amacad.org/daedalus or contact [email protected]. n
8 Bulletin of the American Academy of Arts & Sciences, Summer 2018 projects and publications
New Humanities Indicators on Career Outcomes for Recipients of Advanced Degrees
n a series of recent reports, leaders in the sciences, humanities, and higher education have called for additional data on Ithe career outcomes of recipients of graduate degrees.1 Drawing on national surveys of college graduates, the American Academy’s Humanities Indicators (www.HumanitiesIndicators.org) offers a fresh perspective on the outcomes of recipi- ents of advanced degrees, providing a snapshot of their earnings, occupations, and job satisfaction.
The Trends for Ph.D.s
Employment trends among doctoral students are a subject of par- These trends, combined with growing difficulties in the academ- ticular concern, as recent data show a substantial shift in the job ic job market, have raised renewed questions about the purpose of market after the recession. In new findings about the employment doctoral study and the preparation of students for future careers. commitments of Ph.D.s at the time they earn their degrees, the The leading scholarly societies in the humanities have focused con- Indicators report a sharp decline in the share with jobs or com- siderable effort over the past five years on promoting “career diver- mitments for postdoctoral study. Among new Ph.D. recipients in sity” in doctoral training, and a new report by the National Acade- 2016 (the most recent year with data), al- most 62 percent of doctoral degree recip- ients had a commitment for employment or postdoctoral study after earning their degree, which marked a substantial de- Degree Holders Indicating They Are “Very” or “Somewhat” cline in just ten years and the lowest point on record. Satisfied with Their Job, by Field of Degree, 2015 Doctoral degree recipients in the hu- manities appeared to be the hardest hit, Terminal Bachelor's Degree Terminal Master's Degree PhD as barely half of new humanities Ph.D. re- 120 cipients reported a firm commitment for employment or postdoctoral study. The 100 humanities have traditionally lagged be- hind other fields on this measure, but the 80 t n
share reporting a job or postdoctoral study e
c 60 commitment after graduation fell 22 per- r e cent from 2006 to 2016. While the human- 40 ities experienced the largest decline, every field except for the behavioral and social 20 sciences saw their shares of doctoral stu- dents with a definite job commitment fall 0 by more than 15 percent. Arts All Fields Business Education Humanities Engineering Life Sciences
Physical Sciences 1. See, for instance, National Academies of Sci- Health & Medical Sciences ences, Engineering, and Medicine, 2018. Grad- Behavioral & Social Sciences uate STEM Education for the 21st Century (Wash- Fie d of ighe t egree ington, D.C.: The National Academies Press, 2018); Rita Karam et al., Managing the Expansion of Graduate Education in Texas (Santa Monica, Figure 1 Calif.: rand Corporation, 2017); and Jeffrey Allum et al., Understanding PhD Career Pathways for Program Improvement (Washington, D.C.: Source: National Science Foundation, 2015 National Survey of College Graduates. Data analyzed and Council of Graduate Schools, 2015). presented by the American Academy’s Humanities Indicators (www.humanitiesindicators.org).
Bulletin of the American Academy of Arts & Sciences, Summer 2018 9 projects and publications
were teaching at the postsecondary level as their principal occupation, as compared to Median Annual Earnings of Full-Time Workers, 29 percent of employed doctoral degree re- cipients in all fields combined. by Highest Degree and Field of Degree, 2015 Even in the 2016 cohort of Ph.D.s with job commitments, the humanities gradu- Terminal Bachelor's Degree Terminal Master's Degree PhD ates appeared much more likely to look to 140,000 colleges and universities for employment. Despite the recent decline in employment 120,000 commitments at graduation, and a sharp
100,000 drop in jobs advertised with scholarly soci- eties in the field, 76 percent of humanities
r 80,000 doctoral degree recipients with an employ- a
o ment commitment in the United States in- 60,000 dicated they would be taking a job in the ac- 40,000 ademic sector (including full- and part-time faculty and administrative appointments). 20,000 Among doctoral degree recipients from all 3 0 * fields, the share was less than 45 percent.
Arts Despite the challenges for recent Ph.D.s
All Fields Business Education on the job market, overall, doctoral de- Engineering Humanities Life Sciences gree recipients seem satisfied with their Physical Sciences jobs. The Indicators report that 91 percent Health & Medical Sciences Behavioral & Social Sciences of Ph.D. recipients were “very” or “some- Fie d of ighe t egree what” satisfied with their employment in 2015 (Figure 1). Once again, however, doc- Figure 2 toral degree recipients in the humanities were the notable exception. The share of Source: National Science Foundation, 2015 National Survey of College Graduates. Data analyzed humanities Ph.D.s employed outside ac- and presented by the American Academy’s Humanities Indicators. *Sample size for doctoral ademia who reported they were satisfied degree recipients in the arts was too small for an accurate estimate of earnings. with their jobs was more than 11 percentage points below that of humanities Ph.D.s in mies calls on the stem fields to focus on training their students for academia (80 percent as compared to 91 percent). In contrast to the diverse “professional contexts.”2 humanities Ph.D.s, doctoral degree recipients from all fields with A separate set of Indicators, highlighting the wide occupation- employment outside of academia reported a high level of job sat- al differences among recipients of doctoral degrees, suggests why isfaction (92 percent), again underscoring the unusual focus of hu- the humanities arrived at the career diversity issue before the stem manities Ph.D.s on college and university employment. fields. Ph.D. recipients in the humanities appear much more likely The disproportionate share of humanities Ph.D.s employed in ac- to take employment in postsecondary teaching in comparison to ademia also has another effect, as the relatively low salaries for col- other fields. As of 2015, 56 percent of employed humanities Ph.D.s lege and university faculty–particularly for faculty in the human- ities–lead to below-average earnings relative to other fields. The
2. For the humanities, see Anthony T. Grafton and Jim Grossman, “No More Plan B,” Chronicle of Higher Education, October 9, 2011; and Vimal 3. For recent trends in jobs advertised with scholarly societies in the hu- Patel, “Grants Seek to Foster a Culture Change in Humanities Graduate manities, see “A Path Forward as Academic Job Market in Humanities Fal- Education,” Chronicle of Higher Education, August 9, 2016. For the stem ters,” Academy Data Forum (August 28, 2017), available online at www fields, seeGraduate STEM Education for the 21st Century. .amacad.org/content/research/dataForumEssay.aspx?i=22902.
10 Bulletin of the American Academy of Arts & Sciences, Summer 2018 career outcomes for recipients of advanced degrees
Indicators reports median earnings of $99,000 for doctoral degree with their contribution to society, but also had one of the highest recipients in all fields (see Figure 2). The median earnings range shares of satisfaction with their salaries (82 percent). Master’s de- from a low of $77,000 for humanities Ph.D.s to a high of $125,000 gree recipients from engineering and business, on the other hand, for doctorate recipients in engineering. reported relatively low levels of satisfaction with their contribution to society (at below 83 percent) while also having the highest shares Careers with Master’s Degrees of satisfaction with their salaries (above 80 percent). All these studies represent snapshots of degree recipients at par- While the career outcomes of Ph.D.s tend to receive the most at- ticular moments. In future studies, the Indicators hopes to provide tention, due to their role in academia and the extended time it takes better tracking of degree recipients over time, in order to measure to earn the degree, a substantially larger number of students earn how recipients of advanced degrees fare from the start of a profes- master’s degrees each year. The Indicators also provides new infor- sion with one of these degrees to the end of their careers. mation on the career outcomes of those whose highest degree is a For more information about the Humanities Indicators, please terminal master’s degree. While there is no comparable data about visit www.humanitiesindicators.org or contact the Indicators staff the recent trends in their job outcomes as they earn their degrees, at [email protected]. n new reports from the Indicators find that they also have high lev- els of job satisfaction, have higher median earnings than those who lack a graduate degree, and are more likely to be in higher-level jobs. Almost 90 percent of employed graduates with a terminal mas- ter’s degree were in a management or professional position in 2015, as compared to 62 percent of graduates with just a bachelor’s de- gree. And that difference shows up in their median earnings, as ter- minal master’s degree recipients had median earnings of $77,000, as compared to $60,000 for those working with only a bachelor’s degree. Among recipients of terminal master’s degrees, gradu- ates from the arts and education had the lowest median earnings (at $52,000 and $56,000, respectively), while graduates from busi- ness and engineering programs had the highest median earnings ($105,000 and $102,000, respectively). Overall, 89 percent of the recipients of terminal master’s de- grees reported they were “very” or “somewhat” satisfied with their employment in 2015, and graduates working with a terminal mas- ter’s degree reported high levels of satisfaction with most aspects of their jobs. Across all fields, terminal master’s degree holders ex- pressed the least satisfaction with their opportunities for advance- ment (less than 66 percent reported satisfaction on this measure) and their salaries (77 percent). On other, less tangible measures, however, such as their contribution to society and the intellectual challenge of their work, the shares reporting satisfaction were gen- erally 84 percent or higher. There were interesting variations between graduates from partic- ular fields on these measures. For instance, recipients of terminal master’s degrees in education had the highest levels of satisfaction on most aspects of their jobs (especially in their perceived contribu- tion to society, at nearly 94 percent), but reported the lowest shares of satisfaction with their salaries (71.5 percent). Graduates from the health and medical sciences had similarly high levels of satisfaction
Bulletin of the American Academy of Arts & Sciences, Summer 2018 11 presentations
Don M. Randel Award for Humanistic Studies: Acceptance Remarks A Philosophical Approach to Anger and Fear
n April 12, 2018, the American Academy of Arts and Sciences presented the Don M. Randel Award for Humanis- tic Studies to Martha C. Nussbaum (University of Chicago). An introduction by Paul Guyer (Brown Universi- Oty) and acceptance remarks from Martha Nussbaum appear below.
ceed beyond the wildest dreams that anyone nary total of fifty-six honorary degrees, and could have had at the age of twenty-one. many other distinguished awards, includ- It is an honor for me because Martha has ing most recently the Kyoto Prize in Arts been for almost that many years one of the and Philosophy. most insightful and productive philoso- For what? Two of Martha’s titles suggest phers and scholars on our scene, and with- the unifying threads of an extraordinarily out question the most significant public in- diverse body of work, the “intelligence of tellectual that philosophy in America has emotions” on the one hand and the “fron- produced in decades. Indeed, I do not think tiers of justice” on the other. In the pref- we have seen a public philosopher like her ace to the book she is currently working on, since John Dewey or before him our former some of which she presented at Brown a few neighbors William James and Josiah Royce. weeks ago, she describes these as two sepa- Martha would be just as fitting a winner for rate sides of her work, but I think they are any award in public service as for our distin- deeply connected. guished award in humanistic studies. On the topic of justice, Martha has Martha Nussbaum’s academic career has pushed beyond the path-breaking work been exceptional. After earning her Ph.D. of John Rawls, whose Theory of Justice ap- Paul Guyer in classics and philosophy at Harvard, she peared while we were in graduate school Paul Guyer is the Jonathan Nelson Professor of was a Junior Fellow of the Society of Fel- and has been such an enduring influence on Humanities and Philosophy at Brown University. lows and Assistant Professor of Classics and so many of our generation and since. Rawls He was elected a Fellow of the American Acad- Philosophy there before moving to tenured himself pushed beyond Kant by accepting as positions at Brown, where she is still re- his own first principle of justice Kant’s defi- emy in 1999. membered fondly and is a welcome annual nition of justice as the greatest freedom for visitor, and then the University of Chicago. each compatible with equal freedom for all, Introduction From her first book, a scholarly work on Ar- but adding as his second principle equal op- istotle’s biology published just a few years portunity for positions and offices and the t is a pleasure and an honor for me to in- after she finished her Ph.D., she has gone on requirement that differential rewards be to Itroduce the sixth winner of the Don M. to publish more than twenty further books, the advantage of the least well-off. Martha Randel Award for Humanistic Studies in its including such indispensable works as The has in turn pushed beyond Rawls by argu- forty-year history: Martha C. Nussbaum, Fragility of Goodness, Women and Human De- ing for equal opportunity not just for offic- the Ernst Freund Distinguished Service Pro- velopment, Upheavals of Thought: The Intelli- es and income but for the full range of what fessor of Law and Ethics in the Law School gence of Emotions, Frontiers of Justice, Liberty she calls human capabilities, and not just for and Department of Philosophy of the Uni- of Conscience: In Defense of America’s Tradition those individuals in an historical position versity of Chicago, where she also teach- of Religious Equality, Political Emotions, An- to bargain over a social contract, but for the es in the Classics Department, the Politi- ger and Forgiveness, and most recently, with full range of human beings, including wom- cal Science Department, and in the Divin- her Chicago colleague Saul Levmore, Aging en, the disabled or infirm, all those who in ity School. It is a pleasure for me because I Thoughtfully. one society or another have been classified have known Martha since we began grad- Nussbaum has also edited or co-edited as minorities, and even beyond that for an- uate school together almost half a century another two dozen multi-author volumes. imals. And it is Martha’s stress that justice ago, and it is a pleasure to see a friend suc- She has received at last count the extraordi- requires opportunity for the full develop-
12 Bulletin of the American Academy of Arts & Sciences, Summer 2018 a philosophical approach to anger and fear
ment of human capabilities that links the Does democracy really one side of her work to the other. Among human capabilities she recogniz- ask people to put es the development of emotions, the basis of love, attachment, gratitude, grief, and much anger aside? . . . And more, as well as more obvious bodily and in- if democracy does ask tellectual capacities, practical reason, con- trol over one’s environment, and the like. people to give up anger, For her, human beings must have the op- how would we protest portunity to develop and express their emo- tions but also to learn how to control them. against egregious Justice is the sum of the conditions that al- lows human beings to be fully human, and injustice? itself can arise only with both the expres- sion and the control of human emotions. who is here. In general, I could not do my This is the ideal that underlies all of Martha work without that great university, both its Nussbaum’s work. law school and its philosophy department, Martha C. Nussbaum which have created an ideal environment Martha C. Nussbaum is the Ernst Freund Dis- for work, serious criticism, and teaching. tinguished Service Professor of Law and Eth- As Paul said, my career has focused on ics at the University of Chicago, with appoint- two areas: normative theorizing about jus- tice and investigation of the nature and role ments in the Law School and the Philosophy De- of the emotions. Increasingly I have been partment. In addition, she is an Associate in the bringing the two together and thinking of Classics Department, the Divinity School, and the role emotions play in moving us toward the Political Science Department. She was elect- or, as the case may be, away from a just and ed a Fellow of the American Academy in 1988. decent society. All of this work has been continually nourished by my long study of t is a delight to be introduced by Paul the history of Greek and Roman philoso- IGuyer, not just an old friend but a phi- phy, very much including the philosophi- losopher whom I deeply admire and who cal elements of literature. In the process, I exemplifies a rigor, insight, and dedication have also made an attempt to address a wid- that show our profession at its best. I am er public and to play the role of what peo- extremely grateful to the Academy for the ple call a “public philosopher,” something honor of this award, and especially honored quite difficult to do in this country. But I that it is named for Don Randel, who has have tried to do it always in a way that up- been such a paragon of commitment to the holds philosophical standards and honors humanities throughout his distinguished the work of other thinkers, past and present. career. And of course I have been so happy Let me, then, give you just a small exam- to have worked under Don’s leadership at ple here, showing how a philosophical ap- the University of Chicago, where we shared proach to the emotion of anger and the fear so many commitments, not least including that so often underlies it can help us come a deep love of music. Don’s commitment to to grips with the challenges of our political the humanities and also, as it happens, his moment–the theme of my Jefferson Lec- love of music find fitting continuation in the ture in 2017, so this is but a sketch of a much Humanities Deanship of Anne Robertson, fuller argument.
Bulletin of the American Academy of Arts & Sciences, Summer 2018 13 presentations
I start with poetry, with the ancient Greek racy really ask people to put anger aside? vine intervention. (Gandhi agrees.) Or, playwright Aeschylus’ depiction of the birth (The Greeks and Romans didn’t think very even more subtly, we find ourselves wishing of democracy and the rule of the law in Eu- well of anger or associate it with masculin- that the person who wronged us will simply menides, the third play of the Oresteia. The ity, but Americans certainly do!) And if de- have a miserable life in the future, that the protagonists of this drama are some rather mocracy does ask people to give up anger, second marriage of your betraying spouse is unpleasant characters. Called Furies or Er- how would we protest against egregious a dismal failure. inyes, they help wronged individuals wreak injustice? But (I then argue) the idea of retributive vengeance on those who have killed a mem- To go further, however, we need a philo- payback, though ubiquitous and deeply hu- ber of their family. The Furies are said to be sophical analysis, and in the Western tradi- man, is empty and quite unhelpful, if what ugly and foul, more like rabid dogs than like tion the definition of anger that influences we want is to change the future, which is the human beings. Their eyes drip a hideous all subsequent thinkers is Aristotle’s. (It’s only thing we can change. Capital punish- liquid; they are even said to vomit up clots actually similar to definitions in Indian phi- ment does not bring back the life that was of blood that they have ingested from their losophy, the only non-Western tradition I lost; punitive litigation does not make a new prey. This is Aeschylus’ way of imagining know anything about. We should remem- future after a broken marriage. So, I then the obsessiveness and ugliness of retribu- ber always that philosophical thinking has investigate the futility of anger at greater tive anger. Unreformed, these Furies could roots in many cultures. And, it also has been length, and show how this kind of empty not be helpful in Athena’s project to found a validated by modern psychology: philoso- thinking is often closely linked to fear and democracy involving legal trials and, more phers have to be attuned to the insights of insecurity, to an underlying sense of pow- generally, the rule of law. other disciplines.) erlessness that reaches back to infantile ex- perience, but that is exacerbated in times of personal or social unrest. Feeling powerless, The idea of retributive payback, though ubiquitous we want control in an uncertain world, and anger gives an illusion of control: inflicting and deeply human, is empty and quite unhelpful, if pain on someone feels powerful, and dis- what we want is to change the future, which is the tracts us from the messy and difficult task of making a productive life. only thing we can change. In politics this is true in spades. Our na- tion right now has many real political and economic problems to solve: outsourcing, The end of the drama, however, shows Aristotle says that anger is a painful re- automation, the claims of immigrants and the Furies not just accepting legal con- sponse to a significant damage, to some- asylum-seekers, the demands of long-mar- straints but also fundamentally shifting thing or someone that the angry person ginalized people and groups. It is human to their sentiments. They get a place of hon- cares a lot about–and a damage this person feel helpless in the face of such problems. or in the city, but the exchange is that they believes to have been wrongfully inflicted, How easy, then, to turn instead to anger and now want different things. They agree to not just accidental. So far, so uncontrover- scapegoating, imagining that inflicting pain foster the welfare of all the citizens, de- sial, and anger so defined seems not bad or on an opponent will fix the problem. (And scribing their new mood as “looking to the destructive, but an ingredient of a good so- note that this way of reacting is bad wheth- future with gentle intent” and also as “a ciety’s confrontation with wrongdoing. er the opponent has actually wronged you or mindset of common love.” Perhaps most But then the Furies enter. Aristotle claims not: even real wrongs need to be addressed important, they agree to listen to the voice that a wish for retribution or payback, some in a constructive and cooperative spirit, not of persuasion. They are transformed phys- sort of pain for pain, is an essential part of in the spirit of the Furies.) ically in related ways: they stand up, they anger as commonly experienced. This needs A great part of my new book is occupied are given robes to wear, and they also get a long discussion, but if we cut to the chase by tracing the complex interrelationships a new name: the “Eumenides,” or “kindly I think Aristotle is correct: when we are an- between fear and anger, showing how fear ones,” rather than Furies. So, what is the gry we do want the wrongdoer to suffer, if turns anger toxic, turning people toward drama saying about anger? Does democ- only through legal punishment or even di- retributive fantasy and away from the hard
14 Bulletin of the American Academy of Arts & Sciences, Summer 2018 a philosophical approach to anger and fear
Philosophical analysis, animated by liter- We should recognize the serious wrongs that occur ary imagination, does not solve our politi- in our society, name them, and protest against cal problems. For that we need sound eco- nomic planning, historical and scientific them. This part of Aristotelian anger, however, is knowledge, and multidisciplinary coopera- separate from the payback part. . . . We can demand tion. And we also need an open-minded and well-educated electorate and politicians in- justice without wishing for painful retribution for terested in communicating economic, his- our opponents. torical, and scientific knowledge to them, rather than just playing on their anger for their own advantage. But philosophy can constructive work that must be done to case, he said the same thing: ordinary anger help us understand ourselves and see where solve social problems. brings people to a protest movement, and the problems lie, and it can also help us to But my Aristotelian analysis of anger also when they arrive they typically want to in- identify some not-so-productive way to re- shows us where Athena’s mediation digs in flict retributive pain. But once they get into spond to them. and offers hope: If we return to his defini- his movement, he continually stressed, that Furthermore, the contribution of philos- tion, there is one part that seems produc- anger has to be, as he put it, “channelized” ophy lies in its methods as well as its con- tive: the recognition that a serious wrong or “purified,” losing its retributive element tent. It can actually help to build the sort has been done. When the facts are cor- and taking on new sentiments of love and of citizenry and the sort of politician that I rect, this part of anger, the protest part so hope. In 1959, he wrote that obstacles to the have just imagined. Following Socrates, phi- to speak, is socially productive. We should goals of a protest movement can be met in losophy approaches people gently, respect- recognize the serious wrongs that occur in two ways: fully, asking them to listen to persuasion our society, name them, and protest against rather than to make a lot of noisy boasts. So One is the development of a whole- them. This part of Aristotelian anger, how- philosophy also embodies part of the solu- some social organization to resist with ever, is separate from the payback part. Even tion we so badly need: a decent, respectful, effective, firm measures any efforts to if ordinary anger typically contains both el- rational, and imaginatively engaged way of impede progress. The other is a con- ements, there is a conceptual separation be- relating to other people. fused, anger-motivated drive to strike tween protest and payback. We can demand In these two related ways, philosophy back violently, to inflict damage. Pri- justice without wishing for painful retribu- contributes to the task that is always be- marily, it seeks to cause injury to retali- tion for our opponents, and indeed, as in the fore us, in Aeschylus’ time and in our own– ate for wrongful suffering . . . . It is puni- play, while joining in a common enterprise since we always must face forward, wherev- tive–not radical or constructive.1 pointed toward future welfare for all. er we are–of building a constructive, lov- Interestingly, this idea was used by Mar- Studying his speeches, we can see King ing, reasonable, and non-retributive society tin Luther King, Jr. in his movement. In all exemplifying repeatedly a determination that pursues human welfare. n the welcome outpouring of work on King, I to name and vigorously protest the heinous would like to mention the contributions of wrongs of racism and Jim Crow, often at © 2018 by Paul Guyer and Martha C. Nuss- philosophers in a first-rate recent collection great risk–while heading off the thought of baum, respectively edited by Tommie Shelby and Brandon Ter- retribution and replacing that thought with ry, To Shape a New World: Essay on the Polit- ideas of constructive work, love, and faith. ical Philosophy of Martin Luther King, Jr., just To view or listen to the presentations, published by Harvard, to which I’m hon- visit https://www.amacad.org/ 1. Martin Luther King Jr., “The Social Organi- awards-2018. ored to contribute, on the topic of King’s zation of Violence,” in The Papers of Martin Lu- thoughts about anger. King read so wide- ther King, Jr., Volume V: Threshold of a New Decade, ly in both literature and philosophy that it January 1959–December 1960, ed. Clayborne Car- son, Tenisha Armstrong, Susan Carson, Adri- is hard to know whether he was influenced enne Clay, and Kieran Taylor (Berkeley: Univer- by this or that particular source. But in any sity of California Press, 2005).
Bulletin of the American Academy of Arts & Sciences, Summer 2018 15 presentations
Francis Amory Prize Acceptance Remarks On Sex and Death
n April 12, 2018, the American Academy of Arts and Sciences presented the Francis Amory Prize to Barbara J. Meyer (University of California, Berkeley). An introduction by David C. Page (Whitehead Institute; Massachu- Osetts Institute of Technology) and acceptance remarks from Barbara Meyer appear below.
I explore differences between males and related process of dosage compensation is females in our own species. This is some- achieved. And you have identified the mas- times a complicated matter. Barbara wise- ter control gene involved in sex determina- ly explores differences between males, who tion. Your research into the mechanisms are makers of sperm, and hermaphrodites, underlying dosage compensation produced who are makers of both eggs and sperm. many key insights into gene regulation, in- Barbara studies these differences in a very fluencing the work on all higher eukaryotes, sexy species that modern biologists refer including humans. And because of you, we to simply as the worm. This is, of course, the truly have a better understanding of life. nematode Caenorhabditis elegans. As the song You are a mentor to many. And your work goes, sex is a many splendored thing, and it has been praised for its elegant genetic anal- presents scholars with an infinite array of ysis followed by beautiful molecular and nuances, distractions, and sideshows. Re- cellular studies, which have continued to searchers are attracted to study sex in our yield a deep and fascinating picture of these own species, in the worm, and elsewhere. processes. You are a true inspiration to your Why has Barbara’s work had such im- colleagues and those who will follow. pact? The answer is actually very simple: As the citation for the Francis Amory David C. Page Barbara has never been distracted by the Prize reads: “With relentless dedication, David C. Page is the Director of the White- many sideshows. Instead, she has consis- determination, and passion, you have deliv- head Institute, Professor of Biology at the Mas- tently pursued the most central, the most ered on science’s promise to provide a more sachusetts Institute of Technology, and a How- fundamental questions about males, fe- expansive sense of who we are, how we fit males, and hermaphrodites. And she has with life on earth, and how we may improve ard Hughes Medical Institute Investigator. He framed her findings in a manner that res- the human condition.” was elected a Fellow of the American Academy onates far beyond the community of what in 2011. we, biologists, affectionately refer to as worm people. Introduction The ability to frame the fundamental ques- tion and to connect the answer to all of life et me start by asking a question. Is any- is what sets Barbara’s mind and her inquiry L one interested in sex? That may be too apart. And that is what we honor tonight. hard a question. How about is anyone inter- It has been said that if we understand the ested in the differences between the sexes? I worm, we understand life. Through your pi- have had the pleasure of being a colleague of oneering research using the amazing nem- our Francis Amory Prize recipient, Barbara atode worm C. elegans, you have shown the Meyer, since the early 1980s. Barbara and interplay between chromosome structure I–as well as her husband Tom Cline–share and function in sex determination. You a passion for using the toolkits of genetics have made groundbreaking discoveries with and molecular biology to understand the respect to how X chromosomes are count- differences between the sexes. ed to determine sexual fate, and how the
16 Bulletin of the American Academy of Arts & Sciences, Summer 2018 on sex and death
The choice of sexual fate is one of the most fundamental, binary developmental decisions in biology, and one that most organisms, from bacteria to man, must make.
Chromosomes and Genes.” He realized and male (1X to 2 sets of autosomes is an X:A ra- became famous for understanding that a tio of 0.5). A diploid worm that has two X chromosomal signal determines sex in fruit chromosomes is a hermaphrodite (2Xs to 2 flies. The idea of a chromosomal sex signal sets of autosomes is an X:A ratio of 1). Im- fascinated me. When I entered the worm pressively, this worm is more skillful than field, I wanted to understand the basis of simply being able to count to two. It can cal- such sex signals. culate fractions. We can generate worms in Many mechanisms of sex determination the lab with unusual combinations of chro- exist. Although not all mechanisms are chro- mosomes, and remarkably, the worm can mosomal, many are based on chromosome figure out the tiny differences in these ra- Barbara J. Meyer counting (Figure 1a). In humans, the Y chro- tios and commit, reproducibly, to becoming Barbara J. Meyer is Professor of Genetics, Ge- mosome, as David Page knows well, deter- a fertile male or hermaphrodite. The worm nomics, and Development in the Department mines sex. In worms, as in fruit flies, sex is de- translates ratios between 0.5 and 0.67 into of Molecular and Cell Biology at the University termined by the number of X chromosomes. the male fate, and ratios between 0.75 and 1 These animals count sex chromosomes, and into the hermaphrodite fate. of California, Berkeley, and a Howard Hughes they count them against the background of That ability fascinated me. My desire to Medical Institute Investigator. She was elected a other non-sex chromosomes called auto- understand the mechanism launched my Fellow of the American Academy in 1995. somes, which I will describe in a moment. studies. What enabled us to figure out part A virtue of studying sex determination is of the answer is that we discovered the ge- t is a great honor and pleasure to be that it is an exquisitely sensitive develop- netic and molecular target of this specific Iamongst some of my best friends on the mental switch that is highly tractable when chromosome-counting mechanism (Fig- planet, and to be able to be in Cambridge, a one thinks deeply about genetics and mo- ure 1c). We found a gene we named xol-1 for place I love, to receive this honor and to share lecular mechanisms. The choice of sexual xo-lethal (male lethal). This is where the it with people I admire so much. I am really fate is one of the most fundamental, bina- death part comes in. I will explain the cause grateful for this opportunity to see you all. ry developmental decisions in biology, and of death shortly. Tonight’s lecture is a brief presentation one that most organisms, from bacteria to When an animal is programmed geneti- about the fundamentals of sex and death. man, must make. The switch results in an cally to be a male, the level of xol-1 is high. They are related in some interesting and in obvious choice between two developmen- When an animal is programmed genetical- some boring ways. I will touch on both. tal fates: male/hermaphrodite in the case ly to be a hermaphrodite, the level of xol-1 As David mentioned, we have taken our of the worm. is low. I wanted to understand what this studies of sex and death all the way from the The worm is unusual in that it is adept switch did and how it knew what to do. genetic underpinnings to in-depth molecu- at calculating fractions (Figure 1b). This A pan balance shows the answer in simple lar and biochemical studies. I will try to give worm not only understands how to count form (Figure 1d). If a diploid organism (AA, you a flavor of the different approaches and the number of X chromosomes, but it can two sets of autosomes) has two X chromo- conclusions. count them with great accuracy and fideli- somes (XX), it becomes a hermaphrodite. If The year 1921 was a landmark time when ty. You and I have two sets of non-sex chro- this diploid organism (AA) has only one X Calvin Bridges, a developmental geneticist, mosomes. We are diploid, and a worm in the chromosome, it becomes a male. We were launched a series of experiments and pub- wild is also diploid most of the time. A dip- able to discover the features of the X chro- lications on the topic of “Sex in Relation to loid worm that has one X chromosome is a mosomes and autosomes that are count-
Bulletin of the American Academy of Arts & Sciences, Summer 2018 17 presentations
ed. We found that specific genes encod- How is the signal interpreted reproducibly the University of California, Berkeley. It au- ed on X chromosomes, called X-signal ele- in an “all or none” manner to elicit either tomatically renders every cell in an embryo ments (xse), act as repressors of xol-1, and male or hermaphrodite development, nev- in 3 dimensions (3D) so that the total num- genes encoded on autosomes called autoso- er intersexual development? We have pi- ber of specifically labeled molecules in each mal-signal elements (ase) act as activators oneered new approaches to answer these cell can be counted. The network is trained of xol-1. The xse repressor genes outcom- questions by developing methods with sin- by comparing a 3D stack of hundreds of pete the ase activator genes to repress xol-1 gle-molecule and single-cell resolution. high-resolution images of an embryo having when present in two copies, due to two X These methods enable us to count the num- all of its cell membranes lit up with a green chromosomes. Or they allow xol-1 to remain ber of molecules made from individual fluorescent protein to a second 3D stack of active when present in one copy. In that sex-determination genes–xol-1, xse, and training images made from the same em- case, the ase activators win. It is a simple ase–in every cell of an embryo and com- bryo having all cell boundaries manually switch. The complication is that the switch pare them across hundreds of embryos with outlined to model intact membrane struc- controls both sex and death. different numbers of chromosomes. ture. The training set takes weeks of labor Although we discovered the molecular The innovation that makes this analysis to prepare per embryo–an arduous task! basis of the sex signal and its direct target, possible is a new network architecture for Then, applying the newly trained neural net- the master sex-determination-switch gene machine learning we are developing with work to a new 3D stack of images from a dif- xol-1, a fundamental question remained: James Sethian, a mathematics professor at ferent embryo automatically segments the cell boundaries with stunning accuracy and Chromosome-Based Sex Determination X:A Signal Determines Sex: speed (a few seconds). Once the cell bound- The Worm Calculates Fractions aries are defined, quantification of all the -la . sapiens D. melanogaster C. elegans beled molecules in a cell can be automated. (humans) (flies) (worms) 1 :2A 2 :3A 3 :4A 2 :2A Now we return to the connection between 2 :4A 4 :4A sex and death. This relationship is best un- Y Y O .5 .6 . 5 1 derstood in the context of some well-known human genetic disorders. I am sure you are all familiar with the condition called Down syndrome, in which three copies of chro- mosome 21 are present instead of two (Fig- Figure 1a Figure 1b ure 2a). The elevated levels of gene products from the extra chromosome 21 cause nu- xol-1 is the Sex-Determination Switch Gene X:A Sex Signal Includes X-Signal Elements merous abnormalities, creating problems that Directs Male Fate (XSE) and Autosomal Signal Elements (ASE) in development. Down syndrome is one of the few examples in which three copies of 1 :2A 2 :2A a human chromosome is even compatible with life. Three copies of almost any other chromosomes would cause a developing fe- tus to die. ol-1 HIGH ol-1 LOW In a similar vein, males and hermaphro- dites in worm species require equivalent levels of X-chromosome products, despite S S S S S the fact that males have only one X and her- Fate Fate S S maphrodites have two. As the nematode sex-determination mechanism evolved, a dosage compensation process co-evolved ol-1 is the direct target of the :A signal ol-1 repressed ol-1 activated to equalize X expression between the sex- Figure 1c Figure 1d es. We found that xol-1 controls not only sex
18 Bulletin of the American Academy of Arts & Sciences, Summer 2018 on sex and death
Trisomy 21 Causes Down Syndrome in Humans Dosage Compensation Strategies Differ . sapiens D. melanogaster C. elegans