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Chronobiology Society for Light Treatment and Biological Rhythms, 30th Annual Meeting, Groningen (The Netherlands), June 21–24, 2018 ABSTRACTS Guest Editors Mirjam Münch, Berlin Anna Wirz-Justice, Basel Basel • Freiburg • Paris • London • New York • Chennai • New Delhi • Bangkok • Beijing • Shanghai • Tokyo • Kuala Lumpur • Singapore • Sydney Abstracts Neuropsychobiology 2017;76:1–46 Published online: May 18, 2018 DOI: 10.1159/000489584 Funding/Disclosures: This work was supported by NIH A1 R01 MH102310. Circadian and Reward Measures Show Robust Bidirectional Relationships in Bipolar Spectrum Disorder in a 20-Day Naturalistic Ecological Momentary Assessment Study A2 Lauren B. Alloy1, Tommy H. Ng1, Madison K. Titone1, The Effects of Exercise and Napping on Laura E. Dennis2, Namni Goel2 Overnight Sleep 1 Department of Psychology, Temple University, Karina Ando1, Hiroyuki Sagayama2, Masaki Takahashi3, 2 Philadelphia, PA, USA; Division of Sleep and Shigenobu Shibata3, Masako Hoshikawa1, Chronobiology, Department of Psychiatry, University of Hideyuki Takahashi1 Pennsylvania Perelman School of Medicine, Philadelphia, 1Japan Institute of Sports Sciences, Tokyo, Japan; 2Japan PA, USA Society for the Promotion of Science, Tokyo, Japan; 3Waseda University, Tokyo, Japan Objectives: Adolescence/early adulthood is an “age of risk” for bipolar spectrum disorders (BSDs). BSDs have been linked to circadian rhythm and reward processing disruptions; such disrup- Objectives: To examine the effect of a 90-min daytime nap tions may serve as risk factors for BSD mood symptoms/episodes. after high intensity intermittent exercise in the morning on over- However, the bidirectional relationships of the circadian and re- night sleep efficiency. ward systems have not been systematically examined in BSD or Methods: Six young male athletes (mean ± SE, age: 23 ± 2 at-risk individuals. years VO2 max: 58 ± 3 mL/kg/min) participated in this study. They Methods: 150 adults (ages 18–27; mean age ± SD, 21.9 ± performed high-intensity intermittent exercise in the morning. The 2.1 y; 88 women), with high reward sensitivity and a BSD (n = 43), exercise session began at 10:30–11:00 am. The high intensity in- at-risk with high reward sensitivity but no BSD (n = 64), and low- termittent exercise consisted of 12 times × 1-min bout of cycling risk individuals with moderate reward sensitivity and no BSD (n = at 100% of VO2 max with 4-min at 60 rpm, and continuous cycling 43) participated in a 20-day naturalistic ecological momentary as- at 100% of VO2 max until exhaustion at last bout. After the exer- sessment (EMA) study, involving 3 phases: 1. Baseline; 2. Goal cise session, the participants ate lunch at 13:00 pm. Nap/no-nap striving and 3. Goal/reward outcome. Salivary dim light melatonin trials were performed at 14:30–16:00 pm randomly for cross com- onset (DLMO) was assessed as a circadian phase marker in each parison and were separated by at least 1 week. Participants ate din- phase and the Morningness-Eveningness Questionnaire (MEQ) ner at 19:30 pm. The bedtime and wake-up time were adapted to assessed chronotype. The Willingly Assumed Set of Statistically each participant and kept consistent between the nap/no-nap trials. Unlikely Pursuits (WASSUP) assessed ambitious goal striving, the The sleep efficiency of the daytime nap and overnight sleep was UPPS Sensation-Seeking subscale determined sensation seeking, monitored by a sheet-shaped body vibrometer. As physiological and the Card Arranging Reward Responsivity Objective Test indices, heart rate and respiration rate were measured overnight. (CARROT) and the SPSRQ Sensitivity to Reward subscale mea- Results: All participants went to bed at 23:30–01:00 and sured reward responsiveness and sensitivity, respectively. The woke up at 06:30–07:30. The length of time in bed did not differ Barratt Impulsiveness Scale evaluated impulsivity. Pearson’s cor- between the nap and no-nap trials. Overnight sleep efficiency was relations were used for statistical analysis. not significantly different between the nap and no-nap trials (93.8 ± Results: Baseline DLMO positively correlated with goal 2.0%; NAP, 93.1 ± 1.8%; No-NAP, p > 0.05). Heart rate and res- striving (r = 0.202, p < < 0.05) and sensation seeking (r = 0.543, piration rate during overnight sleeping were not significantly dif- p < 0.001), and with reward sensitivity ratings and reward-relevant ferent between the nap and no-nap trials. events (r’s = 0.359–0.457, p < 0.005). MEQ negatively correlated Conclusions: The present study suggested that a 90-min with goal striving (r = –0.135, p < 0.05) and impulsivity (r = daytime nap after high intensity intermittent exercise in the morn- –0.174, p < 0.005). Notably, these relationships were maintained ing does not interfere with overnight sleep efficiency in young during the goal striving and reward outcome phases, indicating athletes. Further research is required to investigate the effects of a their stability across time. 90-min daytime nap for recovery after morning exercise on after- Conclusions: Our results demonstrate for the first time that noon performance in competing athletes. a number of validated circadian and reward measures have robust Funding/Disclosures: None. bidirectional relationships in BSD, whereby measures of greater eveningness/later phase (MEQ and DLMO) are related to greater reward sensitivity across various dimensions. © 2018 S. Karger AG, Basel E-Mail [email protected] www.karger.com/nps A3 A4 Synchrony between Bipolar Mood Cycles Effect of Chronotype and Time of and Lunar Tidal Cycles Ended after Initiation Assessment on Cognitive Performance of Light Treatment and Treatment of Katarína Baranyaiová1,2, Kateřina Červená1, Iveta Fajnerová1, Hypothyroidism Tereza Nekovářová1,2 1 2 David H. Avery , Thomas A. Wehr 1National Institute of Mental Health, Klecany, Czech 1Psychiatric Medicine Associates, Department of Republic; 2Faculty of Arts, Charles University, Prague, Psychiatry and Behavioral Sciences, University of Czech Republic Washington School of Medicine, Seattle, WA, USA; 2Intramural Research Program, National Institute of Mental Objectives: The study focuses on the performance of healthy Health, Bethesda, MD, USA individuals in cognitive tests that are a common part of the exam- ination and are key to determining the cognitive deficit in neuro- Objectives: We examined the relationship between the bi- psychiatric disorders. As the patient might be tested at different weekly lunar spring-neap cycle, which modulates the amplitude of times during the day, it is important to determine whether the time the moon’s twice daily tidal cycle, and the timing of mood switch- of the day when the test is performed and chronotype of the par- es in a 67-year old woman with rapid cycling bipol ar II disorder ticipant can affect performance to a clinically significant extent. who received maintenance treatment with lithium. Rapid cycling The aim of this study is to determine 1) the extent of the effect of had begun when nortriptyline was prescribed, and it persisted after chronotype and time of assessment on cognitive performance, 2) the drug was discontinued. After thyrotropin levels became elevat- whether cognitive performance depends on the day time of testing ed during lithium treatment, thyroxine was prescribed. with respect to the subjectively preferred time, 3) identify a battery Methods: The clinical course was documented with calendar of tests suitable for monitoring the effects specific for extreme records of the switches between depression and hypomania/eu- chronotypes and 4) find a battery of tests that are independent of thymia. The mood episodes were plotted in relation to the 14.8-day the observed effects of time of testing. spring-neap cycle. Chi-square periodogram analyses were per- Methods: The study was performed in 2 phases. Firstly, an formed for the time series, and chi-square analysis was done on the online form of the Morningness Eveningness Questionnaire distribution of the times of the mood switches in relation to three (MEQ) was used to identify individuals with extreme morning and 5-day periods in the spring-neap cycle. extreme evening chronotype (MEQ scoring: morning (70–86) and Results: During an initial 12-month period of observation, evening (16–30)). During the ongoing second phase we monitor mood cycles exhibited a significant (p < 0.05) 29 to 30-day peri- the performance of selected individuals in cognitive tests such as odicity that approximated the lunar synodic month. Switches back the Cognitive Performance Test (CPT), Trail Making Test (TMT), and forth between depression and hypomania/euthymia were non- Stroop test, subtests of Wechsler Adult Intelligence Scale (WAIS- randomly distributed (p < 0.0001), with 14 of 15 switches occur- III, etc). Body temperature using iButton thermochrons and phys- ring within two days of full-moon or new-moon peaks of the ical activity with wrist actigraphy was assessed in order to support spring-neap cycle. After light treatment was initiated and doses of chronotype determined by the MEQ questionnaire. Testing takes thyroxine sufficient to treat lithium-induced hypothyroidism were place in the morning (8:00) and in the evening (20:00) hours, on administered, the mood cycles deviated from synchrony with the two separate days (during the weekend). The order of test methods lunar cycle and then ceased to oscillate. and the time of the first examination are pseudorandomized among Conclusions: Findings in this patient are consistent with
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