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Plenary Keynotes Cover Final Agenda Conference-at-a-Glance Eighth Annual Sponsors Short Courses TRAINING SEMINARS Protein Expression Technologies Introduction to Protein Engineering ENGINEERING Display of Antibodies Engineering Antibodies Plenary Keynotes • Be part of a growing event - attendance has Engineering Bispecifics Paul Adam, Ph.D., increased more than 60% since 2013 Engineering Next-Generation ADCs Boehringer Ingelheim • Network with 700 colleagues from 30+ countries THERAPEUTICS at Europe’s largest protein engineering event Christian Klein, Ph.D., Novel Immunotherapy Strategies Roche Pharmaceutical Research and Early • See unpublished data and case studies from Advancing Bispecifics Development industry leaders Novel Therapies for Cancer • Learn from 200 speakers and 125 poster presenters Sandra S. Diebold, Ph.D., National Institute for Biological Standards ANALYTICAL and Control Optimisation & Developability Analytical Characterisation Aggregates & Particles EXPRESSION ON CE C FIRM AN ED Protein Expression Technologies D ! N E Optimising Expression Platforms T T A Protein Purification Technologies Register by D R 30 September Sponsor & Exhibit Opportunities O C Hotel & Travel Information E SAVE UP TO R Registration Information €300 Record Attendance Confirmed! SAVE up to €300, Register by 30 September PEGSummitEurope.com Cambridge Healthtech Institute, 250 First Avenue, Suite 300, Premier Needham, MA 02494 USA Sponsors www.healthtech.com 1 Cover Conference-at-a-Glance CONFERENCE-AT-A-GLANCE Sponsors Short Courses Monday - Tuesday Wednesday - Thursday (am) Thursday (pm) - Friday TRAINING SEMINARS 31 October - 1 November 2-3 November 3-4 November Protein Expression Technologies TS1: Basic Technologies in Introduction to Protein Engineering a Core Protein Expression Cambridge Healthtech ENGINEERING Lab Display of Antibodies TS2: Introduction to Protein Engineering Engineering Antibodies Engineering Bispecifics 1A: Display of Antibodies Engineering Next-Generation ADCs ENGINEERING 4A: Engineering Next- 1B: Engineering Antibodies 1C: Engineering Bispecifics STREAM Pre- Generation Dinner THERAPEUTICS Conference Antibody-Drug Conjugates Short Novel Immunotherapy Strategies Short Courses* Advancing Bispecifics THERAPEUTICS Courses* 2A: Novel Immunotherapy 2B: Advancing Bispecifics and 2C: Novel Therapies for Cancer Novel Therapies for Cancer STREAM Strategies Combination Therapy to the Clinic and Emerging Targets ANALYTICAL ANALYTICAL 3A: Optimisation & 3B: Analytical Characterisation of 3C: Protein Aggregates & Particles Optimisation & Developability STREAM Developability Biotherapeutics Analytical Characterisation TS1: Basic Technologies in Aggregates & Particles EXPRESSION 4C: Protein Purification a Core Protein Expression 4B: Optimising Expression Platforms STREAM Technologies EXPRESSION Lab Protein Expression Technologies * Separate registration required for short courses Optimising Expression Platforms Protein Purification Technologies Sponsor & Exhibit Opportunities Hotel & Travel Information The best biologics technology Registration Information Record Attendance Confirmed! meeting in Europe: a must-attend SAVE up to €300, conference for novel biologics. Register by 30 September - Rakesh D., Ph.D., Vice President, R&D, MedImmune PEGSummitEurope.com Cambridge Healthtech Institute, 250 First Avenue, Suite 300, Needham, MA 02494 USA www.healthtech.com 2 Cover Conference-at-a-Glance PREMIER SPONSORS Sponsors Short Courses TRAINING SEMINARS Protein Expression Technologies CORPORATE SPONSORS Introduction to Protein Engineering ENGINEERING Display of Antibodies Engineering Antibodies Engineering Bispecifics Engineering Next-Generation ADCs THERAPEUTICS Novel Immunotherapy Strategies Advancing Bispecifics Novel Therapies for Cancer ANALYTICAL Optimisation & Developability Analytical Characterisation Aggregates & Particles EXPRESSION Protein Expression Technologies Optimising Expression Platforms Protein Purification Technologies Sponsor & Exhibit Opportunities Hotel & Travel Information Registration Information Record Attendance Confirmed! CORPORATE SUPPORT SPONSORS SAVE up to €300, Register by 30 September PEGSummitEurope.com Cambridge Healthtech Institute, 250 First Avenue, Suite 300, Needham, MA 02494 USA www.healthtech.com 3 Cover SHORT COURSES* Conference-at-a-Glance Sponsors Make the Most of Your Time in Lisbon! Short Courses Maximize your educational and networking opportunities by adding a short course. TRAINING SEMINARS MONDAY, 31 OCTOBER | 09:00 – 12:00 THURSDAY, 3 NOVEMBER | 17:30 – 20:30 (DINNER) Protein Expression Technologies Introduction to Protein Engineering SC1: Cancer Immunotherapy SC5: Troubleshooting and Engineering of Antibody Constructs Fred Arce, Ph.D., University College London Cancer Institute Jonas Schaefer, Ph.D., Head, High-Throughput Binder Selection Facility, ENGINEERING Andrea van Elsas, Ph.D., CSO, BioNovion B.V. Biochemistry, University of Zurich Distinct from other paradigms in medical oncology, cancer immunotherapy aims to treat the Julia Neugebauer, Ph.D., Associate Director, Leader Discovery Programs, Display of Antibodies patient’s immune system. During the past few years, antibodies targeting T cell checkpoint MorphoSys AG proteins have demonstrated unprecedented clinical responses and long-term benefit in Engineering Antibodies Recombinant antibodies vary widely in their biophysical characteristics. In particular, patients diagnosed with melanoma and other advanced cancers. Beyond anti-PD-1 and antibody variable domains differ in their intrinsic thermodynamic stability and may Engineering Bispecifics anti-CTLA-4, other pathways and therapeutic agents are rapidly being translated to clinical require labour-intensive engineering. It is essential to implement antibody engineering practice alone or in combination approaches. strategies in screening and initial characterisation project phases in order to avoid time Engineering Next-Generation ADCs and cost consuming optimisation strategies in later development. Moreover, it is critical SC2: Mutation and Selection Strategies beyond Affinity to understand how poor stability of individual variable domains can limit the biophysical Optimisation properties of small fragments, and also affect production yield, stability and homogeneity of THERAPEUTICS Orla Cunningham, Ph.D., Associate Director, Global Biotherapeutic Technologies, full-length IgGs containing these domains. Novel Immunotherapy Strategies Pfizer, Inc. SC6: Engineering of Bispecific Antibodies Matthew Lambert, Ph.D., Principal Scientist, Global Biotherapeutic Technologies, Advancing Bispecifics Pfizer, Inc. Nicolas Fischer, Ph.D., Head, Research, Novimmune SA Michaela Silacci, Ph.D., Director, Discovery Research, Covagen AG, part of J&J Novel Therapies for Cancer This course will begin with an introduction to the multiple display technology platforms, mutagenesis strategies and library generation options that exist to enable antibody By attending this interactive workshop, you will learn about the various approaches used optimization. In the simplest application, generated libraries can be selected for improved for the engineering of bispecific antibodies and bispecific scaffold-based binding proteins. antigen binding. However, increasingly these strategies are being used for more complex Different technologies will be compared, and examples for applications of bispecific ANALYTICAL applications from humanization to ortholog cross-reactivity, stability, solubility and specificity antibodies in drug development will be presented with a focus on candidates that are Optimisation & Developability optimizations. This workshop will use case studies to help attendees navigate the complex currently being evaluated in clinical trials. Opportunities and challenges in the field of workflows and technological options available to ensure success. bispecific antibodies will be discussed. Analytical Characterisation SC3: Designing Antibodies for Function and Low Risk of SC7: Protein Purification Strategies: Dealing with Proteins that Are Aggregates & Particles Immunogenicity Prone to Aggregate George Octavian Badescu, Ph.D., Senior Director Scientific Affairs, Abzena plc Mario Lebendiker, Ph.D., Head, Protein Purification Facility, Wolfson Centre for EXPRESSION Maria Gonzalez-Pajuelo, Ph.D., Chief Scientific Officer, FairJourney Biologics Applied Structural Biology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem Matthew Baker, Ph.D., Chief Scientific Officer, Abzena plc Protein Expression Technologies This course will provide a comprehensive and detailed outline of hands-on issues for Increased knowledge of elements that contribute to enhancing the immunogenicity of purifying proteins. We will first address general considerations about the protein we want Optimising Expression Platforms protein therapeutics has enabled the development of a preclinical ‘toolkit’ that can be to produce, including issues of activity, solubility, homogeneity, purity, and proper oligomeric used to assess and mitigate against the risk of immunogenicity during the early stages conformation. Aggregation is one of the main obstacles in protein production, so we will Protein Purification Technologies of drug development. For antibody therapeutics a variety of in silico, in vitro and in vivo look at how to monitor for aggregation and comprehend its mechanism. We will also immunogenicity selection/testing technologies are available and these can be used at discuss how to check for the optimal solubility
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