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NIHAA Update and Would Like a Bers in Mid-April

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NIHAA Update and Would Like a Bers in Mid-April The Newsletter of the NIH Alumni Associati on Spring 1991 Vol. 3, No. 1 date Julius Axelrod: Portrait First Cancer Patients Get Of aLate Bloomer Gene Therapy By Rich McManus By Florence S. Antoine Fo1ty-one years ago, a man who A team of NIH scientists led by would later go on to win a Nobel prize immunotherapist and surgeon Dr. Steven arrived at NlH with relatively slim pros­ A. Rosenberg of NCI treated the first pects for achieving distinction. cancer patients in a human gene therapy Back then, lacking a Ph.D., he was a trial Jan. 29. longshot candidate for success. Today, Two patients received transfusions of he concedes resignedly, a man like him special cancer-killing cells removed from wouldn't have a prayer at NIH. their own rumors and a1111ed in the labo­ "There are no opportunities in science ratory with a gene capable of producing a for a late bloomer now," says Dr. Julius potent antitumor toxin, tumor necrosis Axelrod, a guest researcher at NIMH 's factor (TNF). Laboratory of Cell Biology and winner of "This trial will be the first to apply the 1970 Nobel Prize in physiology or gene therapy to cancer, which. in its medicine. many forms , affects millions of people,'' Dr. Bernadine P. Healy, formerly of Ohio's "There are a lot of people who mature Rosenberg said. Cleveland Clinic Foundation, has been named slowly, and they just don' t have a NIH's 13th director, a position open since The ca ncer-killing cells removed from chance," he observed. "You have ro have August 1989. the patient 's tumor are tumor-infiltrating a fast stan today-the best schools, the lymphocytes, or TILs, that have migrated best gmdes, the best fellowships-or you from other parts of the body co the cancer won't get into the system. I was a good Healy Confirmed As site. These cells invade the tumor and but not outstanding student. Opportuni­ Thirteenth NIH Director may have the ability to recognize and de­ ties came and I just made the right stroy tissue from this tumor that has choices." By Carla Game/1 spread to distant parts of the body. (See Axelrod p. 14) On March 21, the Senate confirmed (See Gene Therapy p. 13) the nomination of cardiologist Dr. Bernadine P. Healy, 46. as NTH's 13th di­ In This Issue rector. She is the fi rst woman to hold the In NIHAA Forn111 . Bernard D. Dm·is writes about position of NlH director, a post widely re­ :ea/ in the Ofjke ofScie111ijic l111egrity fl· 3 garded in the nation 's scientific commu­ Nell's from and about NIHAA members fl· 5 nity as the president's top biomedical re­ Science Research Updates p. 8 search appointment. Calvill 8. Baldll'in . .fr.. reports 011 NIH Newspapers reported several months budgets for 1991. 1992 p.11 ago that DHHS secretary Dr. Louis W. Calendar p. 13 Sullivan had chosen Healy for the job; Richard M. Krause desl'l'ibes syphilis President Bush officially announced his research. 1900-1 910 p. 18 intention to nominate her .Jan. 9. Human ge110111£• project meets its market fl· 20 "Her nomination is good news indeed, Editors loosen grip on 111etlical news p. 21 and bodes well for the future of the NlH," FAES ojfers .~radume school m NI/-/ p. 22 Cliildren's Inn h11rgeo11s injirst year p. 23 Dr. Julius Axelrod has, In 41 years at NIH, said Dr. Wi lliam Raub, who has served as seen va rious Institutes rise, pioneered in the NIH 's acting director since August 1989, A-Win.~ addition rises 0 11 east side of Bldg. JO p. 24 chemistry of the nervous system and In drug when Dr. James Wyngaarden resigned. Most·citcd women scie11tist.1· ha1·e NIH tics p. 25 studies, trained scientists, won the Nobel Healy, who served as an NHLBI staff Prize, and, lately, immersed himself in signal fellow here from 1972 to 1974. would re­ NIH Norcs p. 26 transduction research. NIHAA Happenings p. 31 (See Healy p. 2) N I H A A U P D A T E H ealy (co111i1111edfro111 p. I) Stetten Museum Acquires cum 10 IH from Ohio's Cleveland Van Slyke Apparatus Clinic Foundation. where she hm; served Update as chainnan of 1he Research lns1iw1e ln April the DeWin S1enen. Jr. Mu­ since 1985. Recen1ly. she has served on seum of Medical Research will place an several NIH advisory groups including The NII/AA Update l\'l'il'omes /euers am/ m' "'S original Yan Slyke manometric apparatus 1he 1988 panel that debated 1he use of fe­ from rrad1·rs. IVe "·ish 1101 nnly w hring alumni in the lobby area of rhe Claude Pepper news abom NI1-1 . /mt alsn 10 sen·e as a means/or ral tissue in federal biomedical research. Building conference ce111er (Bldg. 3 1. 61h reporting i11forma1io11 abom a/w1111i--their con· Dr. Harvey Klein. chief of 1he Clini­ /'ems. i11for111mi1111 011 recent appoi11111u•11ts. floor). The exhibit will include a brochure cal Cemer 's transfusion medicine clepa11­ lionors. books p11/Jlisliedand Oilier tlerelopme11ts that traces the histo1y of this ins1rumen1. ofinterest llJ tllt'ir col/eag11es. lfyo11 lu11•1• m•ws mem and former Healy associaie, also Named after the famed chemist (l/Jom yourselfor a/mm (l{/ier (l/1111111i. or com· mt'llts 011 (Ind sugg1•s1io11sfor the NIJ/1\A Update. praised 1hc new director. He was a first­ Donald Dexter Yan Slyke. this instru­ year resident w i1h 1he Osler M edical Ser­ pleast' drop a 1Wll' to the editor. \Ve resen·e the ment. developed in the 1920's. is one of rig/it w edit materials. vice at Johns Hopkins when Healy in­ the first devices 1hat success fully i111e­ terned there 1970 to 197 1. gra1ed modem chemist!)' with 1he prac­ K lein sa id whal he remembers most tice of medicine. As a clinical and re­ Editor's Note about Healy was her dedica1ion to her search rool. it was distinctive in i1s versa­ pa1ie111s. "She was extremely conscien­ The NII/AA Update. is tire 11e..·sft'ller ofthe NIH tility. simplicity, and accuracy a'i a quan­ 1ious." he said. recalling that Osler in­ A11111111i Associmio11. Tlze NIHM office is at 91 01 titative instrument. Old Ceorgetnl\'11 Rd.. Bethesda. MD 208/.1. (301) 1ems were required 10 comple1e one of Until the advent 530·0567. the mos1 difficult internships in 1he coun­ ofelectronic. auto­ t!)'. EdiJor: Harriet R. Greenwald mated analyzers. I . "They were supposed to be immedi­ which emerged in NIHAA Newsletter F.ditorial Adl'isory Committee !.. ately available. li1erally all the lime:· he 1he 1960's. the Yan Richard McMt11111s. Clraimw11 said. " She was a grea1favorite among her Slyke manometric Bobbi P. Be1111e11 pa1ie111s and frequen1l y came in to care device was found in ,,, .(i ; . I LindaJ. Brown for 1hem on her rare lime off... almost every cl ini­ I : . Sheldon G. Cohen As NIH direc1or. Healy, a 1970 f'l.'ler c.i. C(llul/iffe cal laboratol)'. Sub­ Mic/i(le/ M. Go11esma11 graduate of Harvard M edica l School. sequently. however, ~I ~ llarriet R. Gree11ll'ald joins three former classmates already es­ most of 1hem were Vicmria l/11rde11 tablished at NIH- Dr. Michael destroyed. The in­ Joe R. lie/ti .I: llan·e.1•K/£'in Gouesman. chief of NCI·s Laboratory of strument in this ex­ I JL ~ Robert C. M(lrti11 Cell Biology: Dr. Herber! M orse. chief of hibit was donated Almer ln11is No1ki11s 1 lnis A. Sal:111a11 the Labora1ory of lmmunopaihology at to the Stetten Mu­ tr Swrm IV/wley NIAID: and Dr. Eric 011esen. chief of the seum by Dr. Rollin Ji • •I 1·· .- , ,_I 1' clinical parasitology section in NlAID's Hotchkiss. fonnerly .~ l-m' J . NII/AA Newsletter Board ofContributing Editors Laborarory ofClinical lnves1iga1ion. of the Rockefeller Institute (now Rockefeller University). Giorgio Bernardi Gonesman said: " I am delighted that II. Franklin 8111111 Dr. Healy will be re1uming 10 NIH. NIH To mark the exhibit"s opening. Dr. Bemar<l 0. Dal'is has done well by our class and we're Hotchkiss will give a seminar on research Roger 0 . Egeberg at the Rockefeller Institute during 1he pe­ Heuryk Eiseuberg looking forward 10 a reunion:· Donal</ S. FredricJ.so11 Before dircc1ing 1he C leveland Clinic riod of widest use of the Yan Slyke appa­ Lars A. 1-la11So11 Foundation, Healy served as deputy di­ ratus. For more infonnation about his IVa/ter IV. Hollwrd llerma11 M. Kalckar rector of 1he Office of Science and T ech­ seminar. call Dennis Rodrigues m 1he Geor1:e Klein nology Policy a11he While House 1984­ Stetten Museum offices. (301) 496-6610. Riclrard M. Krause 1985. From 1977 10 1984 she direc1ed Robert Q. 1'-forston 1he coronary care unil at Johns Hopkins. Cc1rlos Mo11ge Roger Monier A New York Ci1y na1ive, Healy gradu­ Seymour Perry ated from Vassar in 1965. Albert B. Sabin Miclwel Sela 2 S P R N G 1 9 9 1 NIHAAFarum biliries between two offices; their very broad mandates: and the zeal of their Zeal in the Office of present admi nistration. On the maner of structure: while it Scientific Integrity was obviously necessary to srrengtllen the mechanisms at lhe NTH for dealing with By Dr. Bernard D. Davis fraud. the existence of two offices, for a Since administrators naturally wish to function that could well be performed by protect their institutions from embarrass­ one. wastes both money and time.
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