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University of Groningen Fabrication and Mechanical Properties Of University of Groningen Fabrication and Mechanical properties of Supercharged polypeptides based Biomaterials: from Adhesives to Fibers Sun, Jing DOI: 10.33612/diss.116872472 IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2020 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Sun, J. (2020). Fabrication and Mechanical properties of Supercharged polypeptides based Biomaterials: from Adhesives to Fibers. University of Groningen. https://doi.org/10.33612/diss.116872472 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne- amendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 07-10-2021 Fabrication and Mechanical properties of Supercharged polypeptides based Biomaterials: from Adhesives to Fibers Jing Sun Paranimphs: Hongyan Li Yifei Fan The work described in this thesis was carried out at the Zernike Institute for Advanced Materials, University of Groningen, The Netherlands. This work was financially supported by China Scholarship Council (CSC) with the Grant Number 201507720025. Cover designed by Jing Sun and Jiaying Han Printing: Proefschriftmaken Zernike Institute PhD thesis series 2020-06 ISSN: 1570-1530 ISBN: 978-94-034-2434-7 (electronic version) ISBN: 978-94-034-2435-4 (printed version) © Jing Sun, 2020 All rights reserved. No parts of this thesis may be reproduced of transmitted in any form or any means, electronic or mechanical, without permission of the author. Fabrication and Mechanical properties of Supercharged polypeptides based Biomaterials: from Adhesives to Fibers PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. C. Wijmenga and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 10 February 2020 at 9.00 hours by Jing Sun born on 12 December 1989 In Anhui, China Supervisor Prof. A. Herrmann Co-promoter Dr. G. Portale Assessment Committee Prof. M.M.G. Kamperman Prof. J. C. M. van Hest Prof. K. Peneva Dedicated to my beloved wife and families Contents Chapter 1 ............................................................................................................................................... 1 Introduction ........................................................................................................................................... 1 Abstract ................................................................................................................................................... 2 1.1 Introduction ....................................................................................................................................... 3 1.2. Protein-based adhesives ................................................................................................................... 4 1.2.1 Genetically engineered protein-based adhesives .................................................................... 4 1.2.2 Biomimetic adhesives ............................................................................................................. 8 1.3. Protein-based fibers ....................................................................................................................... 12 1.3.1 Strategies for the fabrication of protein-based fibers ............................................................ 13 1.3.2 Regenerated protein fibers .................................................................................................... 14 1.3.3 Recombinant protein fibers ................................................................................................... 15 1.4 Conclusions ..................................................................................................................................... 18 1.5 Motivation and thesis outline .......................................................................................................... 20 References ............................................................................................................................................. 22 Chapter 2 ............................................................................................................................................. 27 Ultra-Strong Bio-Glue from Genetically Engineered Polypeptides ............................................... 27 Abstract ................................................................................................................................................. 28 2.1 Introduction ..................................................................................................................................... 29 2.2 Results and Discussion ................................................................................................................... 29 2.3 Conclusion ...................................................................................................................................... 33 2.4 Experimental section ....................................................................................................................... 33 References ............................................................................................................................................. 48 Chapter 3 ............................................................................................................................................. 51 Biomedical Applications of Ultra-Strong Bio-Glue from Genetically Engineered Polypeptides . 51 Abstract ................................................................................................................................................. 52 3.1 Introduction ..................................................................................................................................... 53 3.2 Results and Discussion ................................................................................................................... 53 3.3 Conclusion ...................................................................................................................................... 57 3.4 Experimental section ....................................................................................................................... 57 References ............................................................................................................................................. 66 Chapter 4 ............................................................................................................................................. 69 Design and Synthesis of Biological Adhesives Based on Polypeptide-Surfactant Complexes ...... 69 Abstract ................................................................................................................................................. 70 4.1 Introduction ..................................................................................................................................... 71 4.2 Results and discussions ................................................................................................................... 72 4.3 Conclusion ...................................................................................................................................... 78 4.4 Experimental section ....................................................................................................................... 79 Reference ............................................................................................................................................ 103 Chapter 5 ........................................................................................................................................... 105 Reversibly Photo-Modulating the Mechanics of Bioengineered Protein Fibers ......................... 105 Abstract ............................................................................................................................................... 106 5.1 Introduction ................................................................................................................................... 107 5.2 Results and Discussions ................................................................................................................ 108 5.3 Conclusion .................................................................................................................................... 113 5.4 Experimental section ....................................................................................................................
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