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Ji Won Sung Transfer KE ZHANG, PH.D. Department of Chemistry and Chemical Biology Northeastern University 360 Huntington Ave, Boston MA 02115 Tel: (617) 373-4415 | Email: [email protected] Group website: www.northeastern.edu/polymer Google Scholar: https://scholar.google.com/citations?user=whWec_kAAAAJ&hl=en EDUCATION Nanjing University of Technology 2001-2005 B.S. in Applied Chemistry Washington University in St. Louis 2005-2009 Ph.D. in Chemistry Advisor: Prof. Karen Wooley Northwestern University 2010-2012 Postdoctoral fellow in the Department of Chemistry Advisor: Prof. Chad Mirkin EMPLOYMENT Associate Professor Northeastern University 2017-present Department of Chemistry and Chemical Biology Assistant Professor Northeastern University 2012-2017 Department of Chemistry and Chemical Biology HONORS AND AWARDS ACS PMSE Young Investigator Award 2018 Nano Research journal’s Young Innovator Award 2017 NSF CAREER Award 2014 ACS PRF Doctoral New Investigator Award 2014 International Institute of Nanotechnology Outstanding Researcher Award 2012 PUBLICATIONS Peer-reviewed journal articles At Northeastern: Bolded names: undergraduate researchers 1. Tan, X.; Jia, F.; Miller, A. E.; Zhang, K.* “Nucleic acid-based drug delivery strategies”, invited review article for Journal of Controlled Release, under revision 2. Li, H.; Li, Y.; Xiao, Y.; Zhang, B.; Cheng, Z.; Shi, J.; Xiong, J.; Li, Z.; Zhang, K.* “Molecularly well-defined DNA-polymer miktoarm stars for enzyme-resistant nanoflares and carrier-free gene regulation”, Bioconjugate Chemistry, 2020, DOI: 10.1021/acs.bioconjchem.0c00017 (cover article) 1 3. Jia, F.; Song, J.; Kubiak, J.; Santos, P.; Sano, K.; Holten-Andersen, N.; Zhang, K.; Macfarlane, R. “Bottlebrush polymers as nanoscale building blocks for hydrogel synthesis”, under revision at ACS Nano 4. Qin, X.; Si, Y.; Wu, Z.; Zhang, K.; Li, J.; Yin, Y. “Alkyne/Ruthenium(II) complex-based ratiometric SERS nanoprobe for in vitro and ex vivo tracking of carbon monoxide”, Analytical Chemistry, 2020, 92, 924 5. Yin, S.; Wang, N.; Liu, W.; Zhang, K.; Mirkin, C. A.; Li, J. “A metal oxide-MOF composite nanoenzyme for light-free photodynamic therapy”, submitted 6. Shi, X.; Meng, H.; Chen, J.; Gao, Y.; Qu, L.; Zhang, K.; Zhang, X.; Li, Z. “DNA amplifier- functionalized metal-organic frameworks for multiplexed detection and imaging of intracellular mRNA”, ACS Sensors, 2020, DOI: 10.1021/acssensors.9b01759 7. Wu, Y.; Meng, H.; Chen, J.; Jiang, K.; Yang, R.; Li, Y.; Tang, J.; Zhang, K.; Qu, L.; Li, Z. “Accelerated DNAzyme-based fluorescent nanoprobe for highly sensitive microRNA imaging in live cells”, Chemical Communications, 2020, 56, 470 8. Yin, X.; Sun, Y.; Geng, X.; Li, J.; Yang, R.; Zhang, K.; Qu, L.; Li, Z. “Spatiotemporally monitoring cell viability through programmable mitochondrial membrane potential transformation by using fluorescent carbon dots”, Advanced Biosystems, 2020, DOI: doi.org/10.1002/adbi.201900261 9. Xie, Y.; Wang, N.; Li, Y.; Li, J.; Zhang, K.; Yu, R. “Cyclodextrin supramolecular inclusion-enhanced pyrene excimer switching for highly selective detection of RNase H”, Analytica Chimica Acta, 2019, DOI: j.aca.2019.08.059 10. Xiao, Y.; Li, Y.; Zhang, B.; Li, H.; Cheng, Z.; Shi, J.; Xiong, J.; Bai, Y.; Zhang, K.* “Functionalizable, side chain-immolative poly(benzyl ether)s”, ACS Macro Letters, 2019, 8, 399 11. Jia, F.; Li, H.; Chen, R.; Zhang, K.* “Self-assembly of DNA-containing copolymers”, Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00067 12. Wang, D.; Lin, J.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J. C.; Nyoni, Z.; Lu, X.; Zhang, K.* “Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo”, Science Advances, 2019, DOI: 10.1126/sciadv.aav9322 (highlighted in Northeastern News and ScienceTrends) 13. Tan, X.; Lu, H.; Sun, Y.; Chen, X.; Wang, D.; Jia, F.; Zhang, K.* “Expanding the materials space of DNA via organic-phase ring-opening metathesis polymerization”, Chem, 2019, DOI: 10.1016/j.chempr.2019.03.023 14. Gudipati, S.; Zhang, K.; Rouge, J. L. “Towards self-transfecting nucleic acid nanostructures for gene regulation”, Trends in Biotechnology, 2019, DOI: 10.1016/j.tibtech.2019.01.008 (cover article) 15. Wang, N.; Song, L.; Xing, H.; Zhang, K.; Li, J. “Spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues”, Nanoscale, 2019, DOI: 10.1039/C9NR00880B 16. Li, M.; Wang, C.; Di, Z.; Li, H.; Zhang, J.; Xue, W.; Zhao, M.; Zhang, K.; Zhao, Y.; Li, L. “Engineering multifunctional DNA hybrid nanospheres through coordination-driven self- assembly”, Angewandte Chemie International Edition, 2018, DOI: 10.1002/anie.201810735 2 17. Jia, F.; Wang, D.; Lu, X.; Tan, X.; Wang, Y.; Lu, H.; Zhang, K.* “Improving the enzymatic stability and pharmacokinetics of oligonucleotides via DNA-backboned brush polymers”, Nano Letters, 2018, 18, 7378 18. Lu, X.; Zhang, K.* “PEGylation of therapeutic oligonucleotides – From linear to highly branched PEG architectures”, Nano Research, 2018, DOI: 10.1007/s12274-018-2131-8 (invited review article for the 45 under 45 Young Innovator Award special issue) 19. Xiao, Y.; Li, H.; Zhang, B.; Cheng, Z.; Li, Y.; Tan, X.; Zhang, K.* “Modulating the depolymerization of self-immolative brush polymers with poly(benzyl ether) backbones”, Macromolecules, 2018, 51, 2899 20. Li, H.; Zhang, B.; Lu, X.; Tan, X.; Jia, F.; Xiao, Y.; Cheng, Z.; Li, Y.; Zhang, K.*; Mirkin, C. A. “Molecular spherical nucleic acids”, Proceedings of the National Academy of Sciences, USA, 2018, 115, 4340-4344 21. Tan, X.; Burchfield, E.; Zhang, K.* “Light-responsive drug delivery systems” in Stimuli- Responsive and Trigger Drug Delivery Systems, Edited by Singh, A. and Amiji, M., RSC Publishing, London, UK, 2018, 163-191 22. Tan, X.; Zhang, K.* “Photolabile self-immolative DNA-drug nanostructures” in Biomedical Nanotechnology: Methods and Protocols 2nd Edition, Edited by Hurst, S. J., Springer, New York, USA, 2017, 209-221 23. Cressiot, B.; Greive, S. J.; Si, W.; Pascoa, T.; Mojtabavi, M.; Chechik, M.; Jenkins, H. T.; Lu, X.; Zhang, K.; Aksimentiev, A.; Antson, A. A.; Wanunu, M. “Porphyrin-assisted docking of a thermophage portal protein into lipid bilayers: nanopore engineering and characterization”; ACS Nano, 2017, 11, 11931-11945 24. Wang, D.; Lu, X.; Jia, F.; Tan, X.; Xiaoya, S.; Cao, X.; Wai, F.; Zhang, K.* “Precision tuning of DNA- and poly(ethylene glycol)-based nanoparticles via co-assembly for effective antisense gene regulation”, Chemistry of Materials, 2017, 29, 9882-9886 25. Li, Y.; Sun, S.; Fan, L.; Hu, S.; Huang, Y.; K. Zhang.; Nie, Z.; Yao, S. “Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis”, Angewandte Chemie International Edition, 2017, 56, 14888-14892 26. Antczak, N. M.; Packer, M. R.; Lu, X.; Zhang, K.; Beuning, P. J. “Human Y-family DNA polymerase kappa is more tolerant to changes in its active site loop than its ortholog E. coli DinB”, Chemical Research in Toxicology, 2017, DOI: 10.1021/acs.chemrestox.7b00175 27. Wang, N.; Yu, X.; Zhang, K.*; Mirkin, C. A.; Li, J. “Upconversion nanoprobes for the ratiometric luminescent sensing of nitric oxide”, Journal of the American Chemical Society, 2017, 139, 12354-12357 28. Cao, X.; Lu, X.; Wang, D.; Jia, F.; Tan, X.; Corley, M.; Chen, X.; Zhang, K.* “Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction”, Small, 2017, doi: 10.1002/smll.201701432 29. Jia F.; Lu, X.; Wang, D.; Cao, X.; Tan, X.; Zhang, K.* “Depth-profiling the nuclease stability and the gene silencing efficacy of brush-architectured poly(ethylene glycol)-DNA conjugates” Journal of the American Chemical Society, 2017, 139, 10605-10608 30. Jia, F.; Lu, X.; Tan, X.; Wang, D.; Zhang, K.* “Effect of PEG architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides”, Angewandte Chemie International Edition, 2017, 56, 1239-1243 3 31. Lu, X.; Jia, F.; Tan, X.; Wang, D.; Cao, X.; Zheng, J.; Zhang, K.* “Effective antisense gene regulation via non-cationic, polyethylene glycol brushes”, Journal of the American Chemical Society, 2016, 138, 9097-9100 32. Tan, X.; Lu, X.; Jia, F.; Liu, X.; Logan, J. K.; Sun, Y.; Zhang, K.* “Blurring the role of oligonucleotides: Spherical nucleic acids as a drug delivery vehicle”, Journal of the American Chemical Society, 2016, 138, 10834-10837 33. Lu, X.; Tran, T.-H.; Jia, F.; Tan, X.; Davis, S.; Amiji, M.; Zhang, K.* “Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction”, Journal of the American Chemical Society, 2015, 137, 12466-12469 (selected for JACS Young Investigator virtual issue) 34. Tan, Xu; Li, B. B.; Lu, X.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B.; Zhao, J. J.; Zhang, K.* “Light-triggered, self-immolative nucleic acid-drug nanostructures”, Journal of the American Chemical Society, 2015, 137, 6112-6115 35. Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J.; Wooley, K. L.; Pochan, D., “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48, 5621- 5631 36. Nevin, P.; Lu, X.; Zhang, K.; Engen, J. R.; Beuning, P. J. “Non-cognate DNA damage prevents formation of active conformation of Y-family polymerases DinB and Pol kappa”, FEBS, 2015, 29, 561.8 37. Jia, F.; Lu, X.; Tan, X.; Zhang, K.* “Facile synthesis of nucleic acid-polymer amphiphiles and their self-assembly”, Chemical Communications, 2015, 51, 7843-7846 38. Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K.* “Polycondensation of polymer brushes via DNA hybridization”, Journal of the American Chemical Society, 2014, 136, 10214-10217 39. Zhang, K.*; Zhu, X.; Jia, F.; Auyeung, E.; Mirkin, C. A. “Temperature-activated nucleic acid nanostructures”, Journal of the American Chemical Society, 2013, 135, 14102-14015 Graduate and postdoctoral work: 40. Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J.
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