National Aeronautics and Space Administration ANNUAL HIGHLIGHTS of RESULTS from the INTERNATIONAL SPACE STATION October 1, 2015 - October 1, 2016 ANNUAL HIGHLIGHTS of RESULTS from the INTERNATIONAL SPACE STATION October 1, 2015 – October 1, 2016 Product of the International Space Station Program Science Forum This report was developed collaboratively by the members of the Canadian Space Agency (CSA), European Space Agency (ESA), Japan Aerospace Exploration Agency (JAXA), National Aeronautics and Space Administration (NASA), and the Roscosmos State Corporation for Space Activities (Roscosmos). The highlights and citations in this report, as well as all the International Space Station (ISS) results and citations collected to date can be found at: https://www.nasa.gov/stationresults. Managing Editors Tara Ruttley, NASA Judy Tate-Brown, Barrios Technologies Executive Editor Julie Robinson, NASA Cover: ISS crewmember Kate Rubins works on Selectable Optical Diagnostics Instrument (SODI) Diffusion Coefficient Mixture (DCMix) installation inside the station’s Microgravity Science Glovebox (MSG). The MSG is one of the major dedicated science facilities inside the Destiny laboratory and provides a sealed environment for conducting science and technology experiments (ISS049E002652). NASA/TP-2017-219791 Table of Contents Introduction ........................................................................... 1 Publication Highlights: Biology and Biotechnology .................................................. 5 Publication Highlights: Human Research .................................................................. 9 Publication Highlights: Physical Sciences ............................................................... 15 Publication Highlights: Technology Development and Demonstration ................ 19 Publication Highlights: Earth and Space Science ................................................... 23 Publication Highlights: Educational Activities and Outreach ................................ 27 ISS Research Results Publications ................................... 28 To Learn More .................................................................... 39 This long-exposure Earth Observation photo showing the Japanese Experiment Module - Exposed Facility (JEM-EF) was taken by the Expedition 49 crew aboard the ISS during a night pass (ISS049e031731). Introduction To date, research on the International Space This report is intended to provide an overall Station (ISS) has helped answer scientific highlight of research results published questions ranging from “How do fluids flow from October 1, 2015 to October 1, 2016 in space?” to “What are the origins of the from investigations operated on the ISS. universe?”, and the science and technology These results represent the research of returns have grown at a steady pace. approximately 500 scientists around the world The on-orbit international crew have been for investigations sponsored by the National busier than ever performing research and Aeronautics and Space Administration (NASA), technology development activities for use on the Roscosmos State Corporation for Space Earth and in space. As of October 1, 2016, Activities (Roscosmos), the Japanese Aerospace more than 2000 investigations were conducted Exploration Agency (JAXA), the European across the international partnership resulting Space Agency (ESA), and the Canadian Space in more than 1900 publications in journals, Agency (CSA). Like a typical laboratory on conferences, and other gray literature (such Earth, the logistics of the ISS allows for many as magazines, DVDs, and patents). investigations to be carried forward over several ISS crew expeditions, enabling repeated experimentation and data collection important for answering critical research questions. Impacts of these results reach beyond the field of space research into traditional areas of science in multidisciplinary ways. From October 1, 2015 to October 1, 2016, 106 publications were collected as results for investigations operated on the ISS, with the majority representing Biology and Biotechnology and Human Research. This report will share some important highlights of the ISS results published in that timeframe, as well as the complete listings of the ISS results that benefit humanity, contribute to scientific knowledge, and advance the goals of space exploration for the world. The ISS Program Science Office has a team of professionals dedicated to continuously collecting and archiving research results from all ISS utilization activities across the partnership at www.nasa.gov/iss-science. The database captures the ISS experiment summaries and results, and includes citations 1 to the publications and patents as they become a measure reflecting the yearly average number available. The team mines publications from of citations to recent articles published in that the ISS research and technology development journal. It is frequently used as a measure for through many ways, including these examples the relative importance of a journal within its listed below: field; journals with higher impact factors are often deemed to be more important than those • keyword searches with various tools and with lower ones. Impact factors are calculated search engines yearly for those journals that are listed in the • databases such as AIAA, IEEE, Journal Citation Reports. IngentaConnect, JSTOR, J-STAGE, ScienceDirect, Wiley • Web of Science • conference proceedings • science networks such as ResearchGate • email alerts from systems such as Pubmed, Google Scholar, Nature Partner Journal- Microgravity From October 2015 to October 2016, seven • NASA Taskbook and others scientific publications from the ISS have been in the Top 5 journals ranked by Eignefactor as • ISS investigator and international reported by 2015 Journal Citation Reports®, partner websites Clarivate Analytics, 2017, along with the journal’s impact factor. Missing from the list of • personal email exchanges with ISS Top 5 above are Science and Nature (there investigators and international partners were no ISS publications in Science or Nature for this timeframe). This team also tracks and shares the article citations, impact factors and eigenfactors across the ISS partnership. The eigenfactor score is intended to measure the importance All information pertaining to ISS investigations of a journal to the scientific community, by across the ISS international partnership is considering the origin of the incoming citations, continuously updated at http://www.nasa.gov/ and is thought to reflect how frequently an iss-science, and in particular, publications of the average researcher would access content from ISS results can be found at http://www.nasa. that journal. However, the eigenfactor score is gov/stationresults. As of October 1, 2016, over influenced by the size of the journal, so the 1300 journal publications describe ISS research score doubles when the journal doubles in size since the first ISS investigation began in 1998. (measured as number of published articles per Non-journal publications resulting from ISS year). For the time period of October 1, 2015 utilization include 59 patents and over to October 1, 2016, 7 ISS results have been 400 conference proceedings. published in 3 of the top 5 journals by eigenfactor. The impact factor, or journal |impact factor, of an academic journal is 2 Results from the ISS have Results from the ISS can yielded updated insights into provide new contributions how to better live and work to the body of scientific in space, such as addressing knowledge in the areas radiation effects on crew of physical sciences, EXPLORATION health, combating bone DISCOVERY life sciences, and Earth and muscle loss, improving and space sciences that designs of systems that handle advances scientific fluids in microgravity, and how discoveries in multi- to most efficiently maintain disciplinary ways. environmental control. Results from the ISS also have Earth-based applications, including understanding our climate, contributing to the treatments of disease, BENEFITS improving on existing FOR HUMANITY materials, and inspiring the future generation of scientists, clinicians, engineers, technologists, mathematicians, explorers, and artists. Astronaut Kate Rubins floats in front of the windows in the ISS Cupola module (ISS49E050591). 3 Inside the Harmony node of the International Space Station, Expedition 39 Flight Engineer Steve Swanson of NASA works with the Petri Plants experiment on May 13, 2014 (ISS039E020887). 4 5 PUBLICATION HIGHLIGHTS: BIOLOGY AND BIOTECHNOLOGY The ISS laboratories enable scientific experiments in the biological sciences that explore the complex responses of living organisms to the microgravity environment. The lab facilities support the exploration of biological systems ranging from microorganisms and cellular biology to integrated functions of multicellular plants and animals. Several recent biological sciences experiments have facilitated new technology developments that allow growth and maintenance of living cells, tissues, and organisms. NASA’s Commercial for 2 weeks undergo active skeletal changes, Biomedical Testing including bone loss. Additionally, investigators Module-3: Assessment propose that factors associated with spaceflight of Sclerostin Antibody as such as elevated carbon dioxide levels, vascular a Novel Bone Forming changes, and elevated intracranial pressure may Agent for Prevention of be important factors affecting the remodeling DISCOVERY Spaceflight-induced Skeletal