The Dream on the Rock
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Toxicological and Pharmacological Profile of Amanita Muscaria (L.) Lam
Pharmacia 67(4): 317–323 DOI 10.3897/pharmacia.67.e56112 Review Article Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine Maria Voynova1, Aleksandar Shkondrov2, Magdalena Kondeva-Burdina1, Ilina Krasteva2 1 Laboratory of Drug metabolism and drug toxicity, Department “Pharmacology, Pharmacotherapy and Toxicology”, Faculty of Pharmacy, Medical University of Sofia, Bulgaria 2 Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria Corresponding author: Magdalena Kondeva-Burdina ([email protected]) Received 2 July 2020 ♦ Accepted 19 August 2020 ♦ Published 26 November 2020 Citation: Voynova M, Shkondrov A, Kondeva-Burdina M, Krasteva I (2020) Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine. Pharmacia 67(4): 317–323. https://doi.org/10.3897/pharmacia.67. e56112 Abstract Amanita muscaria, commonly known as fly agaric, is a basidiomycete. Its main psychoactive constituents are ibotenic acid and mus- cimol, both involved in ‘pantherina-muscaria’ poisoning syndrome. The rising pharmacological and toxicological interest based on lots of contradictive opinions concerning the use of Amanita muscaria extracts’ neuroprotective role against some neurodegenerative diseases such as Parkinson’s and Alzheimer’s, its potent role in the treatment of cerebral ischaemia and other socially significant health conditions gave the basis for this review. Facts about Amanita muscaria’s morphology, chemical content, toxicological and pharmacological characteristics and usage from ancient times to present-day’s opportunities in modern medicine are presented. Keywords Amanita muscaria, muscimol, ibotenic acid Introduction rica, the genus had an ancestral origin in the Siberian-Be- ringian region in the Tertiary period (Geml et al. -
Amanita Muscaria: Ecology, Chemistry, Myths
Entry Amanita muscaria: Ecology, Chemistry, Myths Quentin Carboué * and Michel Lopez URD Agro-Biotechnologies Industrielles (ABI), CEBB, AgroParisTech, 51110 Pomacle, France; [email protected] * Correspondence: [email protected] Definition: Amanita muscaria is the most emblematic mushroom in the popular representation. It is an ectomycorrhizal fungus endemic to the cold ecosystems of the northern hemisphere. The basidiocarp contains isoxazoles compounds that have specific actions on the central nervous system, including hallucinations. For this reason, it is considered an important entheogenic mushroom in different cultures whose remnants are still visible in some modern-day European traditions. In Siberian civilizations, it has been consumed for religious and recreational purposes for millennia, as it was the only inebriant in this region. Keywords: Amanita muscaria; ibotenic acid; muscimol; muscarine; ethnomycology 1. Introduction Thanks to its peculiar red cap with white spots, Amanita muscaria (L.) Lam. is the most iconic mushroom in modern-day popular culture. In many languages, its vernacular names are fly agaric and fly amanita. Indeed, steeped in a bowl of milk, it was used to Citation: Carboué, Q.; Lopez, M. catch flies in houses for centuries in Europe due to its ability to attract and intoxicate flies. Amanita muscaria: Ecology, Chemistry, Although considered poisonous when ingested fresh, this mushroom has been consumed Myths. Encyclopedia 2021, 1, 905–914. as edible in many different places, such as Italy and Mexico [1]. Many traditional recipes https://doi.org/10.3390/ involving boiling the mushroom—the water containing most of the water-soluble toxic encyclopedia1030069 compounds is then discarded—are available. In Japan, the mushroom is dried, soaked in brine for 12 weeks, and rinsed in successive washings before being eaten [2]. -
Naturstoffe Im Chemieunterricht: Chemie Mit Pilzen
Neue experimentelle Designs zum Thema Naturstoffe im Chemieunterricht: Chemie mit Pilzen DISS,RTATI.N 0ur ,rlangung des akademischen Grades doctor rerum naturalium 1Dr. rer. nat.2 vorgelegt dem Rat der Chemisch -Geowissenschaftlichen Fakultt der Friedrich-Schiller-Universitt Jena von Jan-Markus Teuscher ge oren am 11.08.1972 in (arl-Mar)-Stadt Gutachter: 1: Prof. Dr. Volker Woest, Arbeitsgruppe Chemiedidaktik 2: Dr. Dieter Weiß, Institut für Organische und Makromolekulare Chemie Tag der öffentlichen Verteidigung: 25.05.2011 Inhaltsverzeichnis S e i t e 3 Inhaltsverzeichnis Abbildungsverzeichnis ............................................................................................................. 5 Tabellenverzeichnis .................................................................................................................. 5 1 Einleitung und Zielsetzung ................................................................................................. 7 2 Biologische Grundlage ....................................................................................................... 9 2.1 Betrachtung der Pilze im Wandel der Zeit .................................................................. 9 2.1.1 Vorgeschichtliche Zeit ......................................................................................... 9 2.1.2 Europäisches Altertum – Anfänge der Naturwissenschaft ................................... 9 2.1.3 Mittelalterliche Scholastik ................................................................................. -
Amavadin- BASED VANADIUM COMPLEXES STRUCTURAL INVESTIGATIONS TON HUBREGTSE STRUCTURALINVESTIGATIONS
amavadin- BASED VANADIUM COMPLEXES STRUCTURAL INVESTIGATIONS TON HUBREGTSE STRUCTURAL INVESTIGATIONS STRUCTURAL UITNODIGING VOOR HET BIJWONEN VAN DE OPENBARE VERDEDIGING VAN HET PROEFSCHRIFT OF EN DE STELLINGEN OP AMAVADIN-BASED VANADIUM COMPLEXES VANADIUM AMAVADIN-BASED DINSDAG 17 APRIL 2007 OM 12.30 UUR IN DE SENAATSZAAL ITNODIGING VAN DE TECHNISCHE UNIVERSITEIT DELFT U MEKELWEG 5 DELFT Voorafgaand aan de verdediging is er om 12.00 uur een toelichting voor niet-chemici. Na afloop van de plechtigheid bent u van harte welkom op de receptie in hetzelfde gebouw. Ton Hubregtse Anna Blamanlaan 8 2104 SE Heemstede 023-5283330 [email protected] T PARANIMFEN: . HUBREGTSE Huub Hubregtse [email protected] 06-46277320 Robert de Vries 2007 [email protected] belonging to the thesis ‘Structural investigations of amavadin-based vanadium complexes’ by Ton Hubregtse 1. Strongly acidic ion-exchange resins should not be used to purify molecules that rely on non-covalent bonds. E. M. Armstrong; D. Collison; N. Ertok; C. D. Garner, Talanta , 2000 , 53 , 75–87. H. Kneifel; E. Bayer, J. Am. Chem. Soc. , 1986 , 108 , 3075–3077. 2. The rule that states that the exception proves the rule is proven because there is no exception to this rule that can prove it. 3. The NMR data of Smith et al. can much better be explained when it is considered, given the three possible ligand stereoisomers and the two possible vanadium configurations, that six enantiomeric pairs of the [V( R,S-hidba) 2]-anion can be formed instead of three. P. D. Smith et al. , J. Chem. Soc., Dalton Trans. , 1997 , 4509–4516. -
Amanita Muscaria: Chemistry, Biology, Toxicology, and Ethnomycology
Mycol. Res. 107 (2): 131-146 (February 2003). © The British Mycological Society 131 DOI: 10.1017/S0953756203007305 Printed in the United Kingdom. Review Amanita muscaria: chemistry, biology, toxicology, and ethnomycology Didier MICHELOT1* and Leda Maria MELENDEZ-HOWELL2 1 Museum National d'Histoire Naturelle, Institut Regulation et Developpement, Diversite Moleculaire, Chimie et Biochimie des Substances Naturelles, USM 502 UMR 8041 C.N.R.S., 63 rue de Buffon, F-75005 Paris, France. 2Systematique et Evolution, USM 602, 12, rue Buffon, F-75005 Paris, France. E-mail: [email protected] Received 12 July 2002; accepted 14 January 2003. The fly agaric is a remarkable mushroom in many respects; these are its bearing, history, chemical components and the poisoning that it provokes when consumed. The 'pantherina' poisoning syndrome is characterized by central nervous system dysfunction. The main species responsible are Amanita muscaria and A. pantherina (Amanitaceae); however, some other species of the genus have been suspected for similar actions. Ibotenic acid and muscimol are the active components, and probably, some other substances detected in the latter species participate in the psychotropic effects. The use of the mushroom started in ancient times and is connected with mysticism. Current knowledge on the chemistry, toxicology, and biology relating to this mushroom is reviewed, together with distinctive features concerning this unique species. INTRODUCTION 50 cm diam and bright red, orange, or even orange or yellow, apart from the white fleck. Many species of the The fly agaric, Amanita muscaria, and the panther, A. muscaria complex bear so-called crassospores (Tul- A. pantherina, are the species mainly involved in the loss & Hailing 1997). -
Amanita Muscaria: Chemistry, Biology, Toxicology, and Ethnomycology
Mycol. Res. 107 (2): 131–146 (February 2003). f The British Mycological Society 131 DOI: 10.1017/S0953756203007305 Printed in the United Kingdom. Review Amanita muscaria: chemistry, biology, toxicology, and ethnomycology Didier MICHELOT1* and Leda Maria MELENDEZ-HOWELL2 1 Muse´um National d’Histoire Naturelle, Institut Re´gulation et De´veloppement, Diversite´ Mole´culaire, Chimie et Biochimie des Substances Naturelles, USM 502 UMR 8041 C.N.R.S., 63 rue de Buffon, F-75005 Paris, France. 2 Syste´matique et Evolution, USM 602, 12, rue Buffon, F-75005 Paris, France. E-mail: [email protected] Received 12 July 2002; accepted 14 January 2003. The fly agaric is a remarkable mushroom in many respects; these are its bearing, history, chemical components and the poisoning that it provokes when consumed. The ‘pantherina’ poisoning syndrome is characterized by central nervous system dysfunction. The main species responsible are Amanita muscaria and A. pantherina (Amanitaceae); however, some other species of the genus have been suspected for similar actions. Ibotenic acid and muscimol are the active components, and probably, some other substances detected in the latter species participate in the psychotropic effects. The use of the mushroom started in ancient times and is connected with mysticism. Current knowledge on the chemistry, toxicology, and biology relating to this mushroom is reviewed, together with distinctive features concerning this unique species. INTRODUCTION 50 cm diam and bright red, orange, or even orange or yellow, apart from the white fleck. Many species of the The fly agaric, Amanita muscaria, and the panther, A. muscaria complex bear so-called crassospores (Tul- A. -
PHARMACOLOGICALLY and TOXICOLOGICALLY RELEVANT COMPONENTS of Amanita Muscaria
Mil. Med. Sci. Lett. (Voj. Zdrav. Listy) 2017, vol. 86(3), p. 122-134 ISSN 0372-7025 DOI: 10.31482/mmsl.2017.020 REVIEW ARTICLE PHARMACOLOGICALLY AND TOXICOLOGICALLY RELEVANT COMPONENTS OF Amanita muscaria Jiri Patocka , Barbora Kocandrlova Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia České Budějovice, České Budějovice, Czech Republic Received 14 th July 2017. Revised 15 th August 2017. Published 8 th September 2017. Summary Amanita muscaria , the red fly agaric, is the most famous of all Amanita. The initial history of this fascinating mushroom dates back to at least the 13 th century. The use of mushrooms began in antiquity and is associated with mysticism. The collection and consumption of mushrooms and other plants containing psychoactive substances is now very popular, especially among young people who are experimenting with drugs. Ibotenic acid and muscimol are the main active ingredients of this mushroom, but other substances are likely to be involved in the psychotropic effects. A. muscaria also contains some other non-psychotropic substances that are interesting not only for their chemical structure but also for their biological activity. Current knowledge about chemistry, pharmacology and toxicology regarding this fungus is reviewed in this article. Key words: Amanita muscaria; fly agaric; ibotenic acid; muscimol; stizolobic acid; muscarufine; betalains INTRODUCTION Amanita muscaria (L. ex Fr.) Hooker, the "fly agaric", is the best known of all the Amanitas . The early history of this fascinating fungus dates back at least to the 13 th century. (Fly Agaric) is a mycorrhizal basidiomycete fungus and it is perhaps the most fascinating mushroom on this planet. -
To Download Sample Issue
The Journal of Wild Mushrooming Spring-Summer 2018 Issue 118, Vol.33, No.1-2 $7.95 in U.S., $8.95 in Canada Postmaster: Mailed as Periodical Small spalted bowl showcasing every type of spalting. Turned and spalted by Seri Robinson (test tubes) Full range of colors available from the four pri- mary spalting fungi: Scytalidium cuboideum, Scytalidium gano- dermophthorum, Chlorociboria aeruginascens, Chlorociboria aeruginosa (Wood in the lower left corner) Green zone line from the Ama- zon rainforest of Peru. Many zone lines appear black but are actually just highly concentrated colors. (spalted wood just below) Red zone lines found in the Amazon rainforest of Peru (spalted wood bottom right cor- ner) Red-purple pigment found in the Amazon rainforest of Peru See the full article on p. 15! 2 2 Spring-SummerWinter-Spring 2011, 2018, Mushroom Mushroom the the Journal Journal ISSN 0740-8161 Issue 118 Vol. 33, No. 1-2 Spring-Summer 2018 The Journal of Wild Mushrooming Cover Photo: Amanita jacksonii photographed by Walt Sturgeon. For more of Walt’s photos, see the photo-essay on pp. 56-7. Coordinating Editors: Features Leon Shernoff ([email protected]) 13 A Term Defined, by Anne Yen Editor emeritus: 15 The Old Art and New Science of Spalted Wood, by Seri Robinson Don H.Coombs 22 Getting Started at Knowing Mushrooms, by Lee Schuler 33 A Life Full of Mushrooming, by Chuck Barrows Book Review Editor: Ron Tracy 58 Mushrooms and Microhabitats, by Jack Waytz ([email protected]) 66 Amanita muscaria – The Organometallic Dimension, by Beowulf Glutzenbaum Editorial Advisory Board: 68 An Unusual Poison Control Call, by Bill Bakaitis Scott Redhead Agriculture Canada, Ottawa Departments David Arora 4 Easy Edibles: The Newish Morels, by Bob Sommer and Leon Shernoff Santa Cruz, California 9 Word Puzzle: Morel Names, by Donald and Leon Shernoff 10 Obituary: Maggie Rogers, by Betty Gering Paul Stamets Olympia, Washington 24 The Cooking Column: The Joy of Black Trumpets 26 Book Reviews: The Forest Unseen and The Songs of Trees, reviewed by James M. -
Aminita Muscaria & Amanita Pantherina and Others
AMINITA MUSCARIA & AMANITA PANTHERINA AND OTHERS International Programme on Chemical Safety Poisons Information Monograph (Group monograph) G026 Fungi Please note that further information on Sections 1, 3.1, 3.2 and 8 is pending. 1. NAME 1.1 Scientific name Species of the genus Amanita. The species known to cause the majority of toxic exposures are: Amanita muscaria and Amanita pantherina . The toxins are all isoxazole derivatives. Other Amanita mushrooms contain the same toxins and induce similar toxicity: Amanita muscaria var. Kamtschatica Langsdorff ex. Fr. Amanita regalis (Fr.) R. Mre. (A. muscaria var. umbrina Fr.) Amanita muscaria var. formosa Amanita muscaria var. alba Amanita gemmata (Fr.) Bertillon Amanita velatipes Atk. Amanita cothurnata Atk. Amanita flavovolvata Sing. Amanita strobiliformis (Vitt.) Quel. Amanita pantherina (DC ex Fr.) Secr. Amanita pantherina multisquamosa Amanita pantherina velatipes Amanita pantherina pantherinoides Tricholoma muscaria 1.2 Family Agaricaceae ( Agaricales) The genus is Amanita (Amanitaceae) 1.3 Common name(s) and synonym(s) Amanita muscaria English Fly Agaric German Fliegenpilz, Roter fliegenpilz Spanish Falsa oronja, Amanita matamoscas French Amanite tue-mouche, Agaric aux mouches, fausse oronge Italian Ovulo malefico, Uovolaccio Polish Muchomor czerwony Amanita pantherina English Panther cap. German Pantherpilz, Braunner Knollenblätterpilz 1 Spanish Amanita pantera, galipiermo falso French Amanite panthère, Fausse golmelle Italian Tignosa bigia, Tignosa regata, Agarico panterino Polish Muchomor plamisty 2. SUMMARY 2.1 Main risks and target organs The most frequent cause of intoxication is the consumption of Amanita muscaria by people who mistake it and ignore its toxicity. Amanita muscaria might also be ingested in order to obtain mind-altering effects. The central nervous system is the major target organ. -
Chemical Education
96 CHIMIA 2019, 73, No. 1/2 Columns doi:10.2533/chimia.2019.96 Chimia 73 (2019) 96–97 © Swiss Chemical Society Chemical Education A CHIMIA Column Topics for Teaching: Chemistry in Nature The Fungus Amanita muscaria: From Neurotoxins to The origins of A. muscaria poisoning lie in the neurotoxins Vanadium Accumulation ibotenic acid and muscimol (Scheme 1). Both are derivatives of the heterocycle isoxazole. Ibotenic acid mimics the stimulatory Catherine E. Housecroft* brain neurotransmitter L-glutamic acid (Scheme 1), while muscimol mimics the inhibitory neurotransmitter γ-aminobutyric *Correspondence: Prof. C. E. Housecroft, E-mail: [email protected], [2] Department of Chemistry, University of Basel, BPR 1096, Mattenstrasse 24a, CH- acid (GABA or 4-aminobutanoic acid). Ibotenic acid acts as 4058 Basel an excitatory neurotoxin in contrast to the depressive effects of GABA. After ingestion of A. muscaria, ibotenic acid and Abstract: The fungus Amanita muscaria contains neurotoxins muscimol are rapidly absorbed by the body. The dominant effects which account for its long-time use as a hallucinogen. In on a mammal of ingesting the fungus are agitation and confusion, contrast, A. muscaria is also a bioaccumulator of high levels of consistent with ibotenic acid being the dominant neurotoxin vanadium, the reason for which is still obscure. present.[3] The name fly agaric arises from a traditional use of Keywords: Amavadin · Bioinorganic · Chemical education · extracting neurotoxins and using the extract for controlling flies Chirality · Fungus · Neurotoxins · Vanadium in farming communities.[4] The fungus Amanita muscaria is instantly recognisable by HO HO HO its appearance (Fig. 1) and is an iconic image in fairy stories. -
Introduction
The most widely recognized mushroom: Chemistry of the genus Amanita By: Chen Li and Nicholas H. Oberlies Li, C. and Oberlies, N.H. (2005) The most widely recognized mushroom: Chemistry of the genus Amanita. Life Sciences 78, 532-538. doi:10.1016/j.lfs.2005.09.003 Made available courtesy of Elsevier: http://www.sciencedirect.com/science/journal/00243205 ***Note: Figures may be missing from this format of the document Abstract: Many review papers have been published on mushrooms of the genus Amanita, as these are well known to both scientific and lay audiences, probably due to the toxic and/or hallucinogenic properties of some species. This article aims to supplement the content of previous reviews by categorizing all of the natural products isolated from any species in the genus Amanita. These compounds are subdivided into six major structural types, and references are provided for all species that have been examined chemically. Keywords: Amanita; Mushrooms; Chemical structural classes Article: Introduction Some of the morphological characteristics of the genus Amanita include white spore prints, gills free from the stem, and the presence of a universal veil (Lincoff, 1981). Species of this genus are found commonly throughout the world, and this includes mushrooms known to possess either toxic and/or hallucinogenic properties. Historical evidence suggests that at least three Roman emperors and a Pope may have been among the victims of mushroom poisoning (Block et al., 1955). Even in modern times, it has been estimated that nearly 90% of reported cases of lethal poisonings caused by the consumption of mushrooms, especially in Central Europe and North America, are due to two of the most poisonous species of this genus, the notorious death cap (A. -
Æc §Ióm Ngé §Éc Do ¡N Nêm §Éc Vµ Hiöu Qu¶ Mét Sè Gi¶I Ph¸P Can Thiöp T¹i Tønh S¥N La
BỘ GIÁO DỤC VÀ ĐÀO TẠO BỘ Y TẾ TRƯỜNG ĐẠI HỌC Y HÀ NỘI CAO VĂN TRUNG §ÆC §IÓM NGé §éC DO ¡N NÊM §éC Vµ HIÖU QU¶ MéT Sè GI¶I PH¸P CAN THIÖP T¹I TØNH S¥N LA LUẬN ÁN TIẾN SĨ Y HỌC HÀ NỘI, 2018 BỘ GIÁO DỤC VÀ ĐÀO TẠO BỘ Y TẾ TRƯỜNG ĐẠI HỌC Y HÀ NỘI CAO VĂN TRUNG §ÆC §IÓM NGé §éC DO ¡N NÊM §éC Vµ HIÖU QU¶ MéT Sè GI¶I PH¸P CAN THIÖP T¹I TØNH S¥N LA Chuyên ngành : Y tế công cộng Mã số : 62 72 03 01 LUẬN ÁN TIẾN SĨ Y HỌC Người hướng dẫn khoa học: 1. GS.TS. Phạm Duy Tường 2. PGS.TS. Hoàng Công Minh . HÀ NỘI, 2018 i LỜI CẢM ƠN Tôi xin trân trọng cám ơn: Ban Giám hiệu, phòng đào tạo Sau đai học, Viện Đào tạo Y học Dự phòng và Y tế công cộng trường Đại học Y Hà Nội, Lãnh đạo Cục An toàn thực phẩm - Bộ Y tế đã cho phép và tạo điều kiện cho tôi được tham gia khóa học này. Các thầy, cô giáo trường Đại học Y Hà Nội đã tận tình giảng dạy, hướng dẫn, giúp đỡ tôi hoàn thành chương trình học tập và thực hiện đề tài nghiên cứu. GS.TS. Phạm Duy Tường, PGS.TS. Hoàng Công Minh, các thầy với đầy nhiệt huyết đã hướng dẫn cho tôi từ xác định vấn đề nghiên cứu, xây dựng đề cương, chia sẽ thông tin và hoàn thành luận án này.