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PCF 2008 Progress Report

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ENDURANCEE N D U R A N C E 20082008 Progress Progress Report Report pcf.org pcf.org Finishing the Race pcf.org The Prostate Cancer Foundation (PCF) was founded in 1993 to find better treatments and cures for prostate cancer. Through its unique model for identifying and selecting promising research programs and rapid deployment of resources, the PCF has funded more than 1,500 programs at nearly 200 research centers in 20 countries around the world. As the world’s leading philanthropic organization for funding prostate cancer research, the PCF is now a foundation without borders. Its advocacy for increased government and private support of prostate cancer research programs has helped build a global research enterprise of nearly $10 billion. In 2008, 40 percent fewer men in the U.S. died from prostate cancer compared to what was once projected in 1996. The PCF is a force of HOPE for more than 16 million men and their families around the world who are currently facing the disease. With milestones achieved and challenges ahead, the work of the PCF is enduring. We remain committed to finishing a race that ends when death from prostate cancer is no longer an outcome. Table of Contents Founder/CEO Letter 1 5-Year Revenue History 2008 Spending Connecting Cancer and 5 $ Millions $0.82 Prostate Cancer Research Mission Lifestyle 40 $37.2 $35.4 $0.76 $0.06 Advances in Prostate 6 35 Research Grants & Public Education Cancer Research: 2008 $31.1 Programs Support & Advocacy 30 $28.2 Challenge Awards 8 Young Investigators 10 25 $22.0 A Global Research 14 20 $0.11 Fundraising Enterprise 15 A Special Thank You 16 10 Appeal for Support 23 $0.07 5 Administration Donation Opportunities 24 0 Financial Statements 25 2004 2005 2006 2007 2008 Report of Independent 28 Auditors A Tribute to the Vinecki Family Board of Directors 29 This Progress Report is dedicated to the Vinecki family. Michael Vinecki was diagnosed with prostate cancer on and Leadership Team his 40th birthday in May 2008. Since then the family has worked tirelessly in support of prostate cancer awareness. Ten-year-old Winter (see cover photo) participated in the adult Athletes for a Cure Triathlon in September. She and Team Winter have helped raise more than $125,000 for advanced research. Michael lost his battle to cancer in March 2009. He and his family have touched many with their selflessness and caring. We are honored by their support. FINISHING THE RACE Endurance for Challenging Times Dear Friends, The Prostate Cancer Foundation (PCF) continues to lead • Studies at ten U.S. sites of the Clinical Trials the fight against prostate cancer and give hope to Consortium, in partnership with the U.S. Department more than 16 million men and their families around the of Defense Congressionally Directed Medical world. Thanks to nearly 68,000 donors who contributed Research Programs (CDMRP). Since 2005, the Clinical Trials Consortium has initiated 44 clinical trials, Report Progress 2008 in 2008 to support our efforts, we finished the year enabling more than 1,600 patients to participate in able to commit more than $28 million toward specific the study of new medicines for prostate cancer. new research in addition to our existing research allocations. This will bring us closer to our goals of In 2009, the PCF continues to support its existing multi- ending suffering from prostate cancer and finding a year commitments and is funding ten new Creativity cure. Awards to support highly innovative ideas that would otherwise be left unfunded. Among other highlights in 2008, the PCF provided funding commitments for: The PCF’s model of venture philanthropy ensures that • Nine new multi-year Challenge Awards for scientific funds raised for research are distributed swiftly and teams, totaling $21.1 million efficiently to programs showing the most potential to accelerate the discovery and delivery of new therapies • Twenty new three-year Young Investigator Awards for prostate cancer patients. totaling $4.3 million 2008 Milestones 1 Maintaining the Pace • New biomarkers are being identified that can lead to better diagnostics and assessment of patient The number of new prostate cancer cases has risen response. with aging baby boomers, but the annual number of U.S. deaths has actually declined. This medical feat • Innovative targeted therapies are being developed. could not have been accomplished without the work of • Growing appreciation of the role of nutrition and PCF-supported researchers. But much work remains. exercise is leading to cancer prevention and Projections indicate there could be an unprecedented increased survivorship. number of new cases—300,000—and 42,000 deaths annually by 2015 if the death rate remains unchanged. Reaching Beyond the PSA Debate Fortunately, more progress has been made in the past Since 1980, PSA (prostate-specific antigen) screening, five years than in the first three decades following in combination with the digital rectal exam, has helped President Nixon’s declaration of the nation’s war on save many lives. However, because PSA testing can’t cancer in 1971: discern between highly aggressive, life-threatening • We better understand gene fusions that cause and indolent (non-threatening) prostate cancers, prostate cancer. controversy continues around its use. While the screening has served us well as a general “smoke • Research in immunotherapy—therapy to alert the detector” for prostate diseases, we’re supporting the body’s immune system to fight cancer—is advancing. development of better, cancer-specific diagnostic tests. 2008 Milestones 2 These include better technologies for collecting and Many men simply do not want to talk about medical identifying specific circulating tumor cells (CTCs) in problems that exist “below the belt.” To overcome this blood samples and prostate cancer-specific biomarkers problem, the PCF is developing more communication in urine. These are potentially transformational tools directed toward partners and wives, family breakthroughs that can save millions of lives while members, caregivers and younger audiences who are resolving the PSA debate. more open to the message of early detection and treatment. In the past year, the foundation has Building Public Understanding and widened its electronic communications by embracing Government Support Report Progress 2008 new social media outlets, including Facebook and While the PCF’s primary mission is to support research, Twitter. a portion of our communications effort is focused on In our advocacy for increased prostate cancer research providing patients, families and caregivers the latest funding, the PCF identifies projects and researchers information on prostate cancer treatment options and that could benefit from federal funding. We recently lifestyle information. Our website, www.pcf.org, has joined forces with a coalition of prostate cancer attracted a growing following of patients, families and organizations to support continued 2010 donors. appropriations for the Department of Defense’s While prostate cancer is the second-most-common prostate cancer research programs. Members of the cancer in men, it remains one of the least discussed. PCF leadership team continue to participate on task 3 forces and committees that help shape public policy. human suffering from prostate cancer to an end. Since the PCF was founded in 1993, there has been a Thank you for your continuing support. twenty-fold increase in government funding for prostate cancer programs, and our bipartisan advocacy Sincerely, continues. The PCF represented the entire prostate cancer community—researchers, patients, families and healthcare providers—in the drafting process for the Kennedy-Hutchinson Cancer ALERT Act introduced in the U.S. Senate in early 2009. One Team, Many Members One important measure of the PCF’s progress is the increased number of men who survived prostate cancer during 2008. This increase is the result, in large Mike Milken Jonathan W. Simons, MD part, of the remarkable teamwork of our donors, Founder and Chairman President and Chief Executive Officer scientists, patients, caregivers, staffers and others David H. Koch Chair whose lives are affected by this cancer. Together, we are bound to finish what we started in 1993: bringing 2008 Milestones 4 CONNECTING CANCER AND LIFESTYLE The PCF has pioneered the field of diet and exercise as it relates to prostate and other cancers. The body of research linking good lifestyle choices to cancer survivorship, and perhaps prevention, continues to grow. Obesity, excess sugars, and cellular oxidation can foster prostate cancer growth. By stressing the importance of approaching prostate cancer through a commitment to lifestyle changes, the PCF’s guide on nutrition and exercise provides information that can help a man with (or without) prostate cancer build a stronger mind and body. In 2008, the PCF updated the latest lifestyle guidelines for levels, one also lowers the body’s need to produce insulin, Report Progress 2008 prostate cancer patients and recently published an all-new a hormone which is needed to break down sugars. High publication: Nutrition, Exercise and Prostate Cancer. It is a insulin levels have been linked to an increased risk of complete reference for men and their families on the diabetes, heart disease, and prostate cancer growth, importance of exercise and proper nutrition. The guide independent of insulin’s interaction with sugar. was authored by a multidisciplinary team of world experts: Supplementing a balanced diet with multivitamins can be David Heber, MD, PhD, UCLA; Stephen J. Freedland, MD, a benefit, however, supplements must be used with Duke University; Lee W. Jones, PhD, Duke University; caution and do not compensate for a poor diet. Fruits and Jonathan W. Simons, MD William G. Nelson, MD, PhD, vegetables are rich sources President and Chief Executive Officer Johns Hopkins School of of mixed vitamins, David H. Koch Chair Medicine. minerals, antioxidants and The guide discusses the other specialized link between excess body substances that cannot be fat and a man’s chances of replicated in most developing prostate cancer supplements.
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