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Neuroprotective Mechanisms of Red Clover and Soy Isoflavones in Parkinson’S Disease Models
bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted July 5, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson’s disease models Aurélie de Rus Jacquet1,2*, Abeje Ambaw3,4, Mitali Arun Tambe1,5, Sin Ying Ma1, Michael Timmers6,7, Mary H. Grace6, Qing-Li Wu8, James E. Simon8, George P. McCabe9, Mary Ann Lila6, Riyi Shi3,10,11, Jean-Christophe Rochet1,11*. 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA 2Present affiliations: Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, QC, G1V 4G2, Canada, and Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, G1V 0A6, Canada 3Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA 4Present affiliation: Physiology Department, Monterey Peninsula College, Monterey, CA, 93940, USA. 5Present affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA 6Plants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, 28081, USA 7Present affiliation: Berry Blue, Kannapolis, NC, 28081, USA 8Department of Plant Biology, Rutgers University, New Brunswick, NJ, 08901, USA 9Department of Statistics, Purdue University, West Lafayette, IN 47907, USA 10Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA 11Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA * Corresponding authors: Jean-Christophe Rochet: [email protected] Aurélie de Rus Jacquet: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted July 5, 2021. -
Glucosylation of Isoflavonoids in Engineered Escherichia Coli
Mol. Cells 2014; 37(2): 172-177 http://dx.doi.org/10.14348/molcells.2014.2348 Molecules and Cells http://molcells.org Established in 1990 Glucosylation of Isoflavonoids in Engineered Escherichia coli Ramesh Prasad Pandey1,3, Prakash Parajuli1,3, Niranjan Koirala1, Joo Ho Lee1, Yong Il Park2, and Jae Kyung Sohng1,* A glycosyltransferase, YjiC, from Bacillus licheniformis INTRODUCTION has been used for the modification of the commercially available isoflavonoids genistein, daidzein, biochanin A Isoflavonoids are biologically active secondary metabolites and formononetin. The in vitro glycosylation reaction, us- which are produced by most leguminous plants. However, non- ing UDP-α-D-glucose as a donor for the glucose moiety leguminous plants have also been reported to produce isofla- and aforementioned four acceptor molecules, showed the vonoids. Structurally, isoflavonoids differ from flavonoids ac- prominent glycosylation at 4′ and 7 hydroxyl groups, but cording to the position of the phenolic ring B attachment at the not at the 5th hydroxyl group of the A-ring, resulting in the C-3 position of the C-ring, instead of at the C-2 position in fla- production of genistein 4′-O-β-D-glucoside, genistein 7-O- vonoids. A number of isoflavonoid derivatives (more than 1600 β-D-glucoside (genistin), genistein 4′,7-O-β-D-diglucoside, to date) have been identified from different sources (Veitch, biochanin A-7-O-β-D-glucoside (sissotrin), daidzein 4′-O-β- 2007; 2013). In plants, the biosynthetic pathway of most of the D-glucoside, daidzein 7-O-β-D-glucoside (daidzin), daidzein flavonoid groups of compound share the same chalcone inter- 4′, 7-O-β-D-diglucoside, and formononetin 7-O-β-D-gluco- mediate (Pandey and Sohng, 2013). -
Phytoalexins: Current Progress and Future Prospects
Phytoalexins: Current Progress and Future Prospects Edited by Philippe Jeandet Printed Edition of the Special Issue Published in Molecules www.mdpi.com/journal/molecules Philippe Jeandet (Ed.) Phytoalexins: Current Progress and Future Prospects This book is a reprint of the special issue that appeared in the online open access journal Molecules (ISSN 1420-3049) in 2014 (available at: http://www.mdpi.com/journal/molecules/special_issues/phytoalexins-progress). Guest Editor Philippe Jeandet Laboratory of Stress, Defenses and Plant Reproduction U.R.V.V.C., UPRES EA 4707, Faculty of Sciences, University of Reims, PO Box. 1039, 51687 Reims cedex 02, France Editorial Office MDPI AG Klybeckstrasse 64 Basel, Switzerland Publisher Shu-Kun Lin Managing Editor Ran Dang 1. Edition 2015 MDPI • Basel • Beijing ISBN 978-3-03842-059-0 © 2015 by the authors; licensee MDPI, Basel, Switzerland. All articles in this volume are Open Access distributed under the Creative Commons Attribution 3.0 license (http://creativecommons.org/licenses/by/3.0/), which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. However, the dissemination and distribution of copies of this book as a whole is restricted to MDPI, Basel, Switzerland. III Table of Contents About the Editor ............................................................................................................... VII List of -
Amorpha Fruticosa – a Noxious Invasive Alien Plant in Europe Or a Medicinal Plant Against Metabolic Disease?
fphar-08-00333 June 6, 2017 Time: 18:44 # 1 REVIEW published: 08 June 2017 doi: 10.3389/fphar.2017.00333 Amorpha fruticosa – A Noxious Invasive Alien Plant in Europe or a Medicinal Plant against Metabolic Disease? Ekaterina Kozuharova1, Adam Matkowski2, Dorota Wo´zniak2, Rumiana Simeonova3, Zheko Naychov4, Clemens Malainer5, Andrei Mocan6,7, Seyed M. Nabavi8 and Atanas G. Atanasov9,10,11* 1 Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria, 2 Department of Pharmaceutical Biology with Botanical Garden of Medicinal Plants, Medical University of Wroclaw, Poland, 3 Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria, 4 Sofia University St. Kliment Ohridski, Faculty of Medicine, Department of Surgery, Obstetrics and Gynecology, Division of Cardiac Surgery, University Hospital Lozenetz, Sofia, Bulgaria, 5 Independent Researcher, Vienna, Austria, 6 Department of Pharmaceutical Botany, Iuliu Ha¸tieganuUniversity of Medicine and Pharmacy, Cluj-Napoca, Romania, 7 ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania, 8 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, 9 Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland, 10 Department of Pharmacognosy, University of Vienna, Vienna, Austria, 11 Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria Amorpha fruticosa L. (Fabaceae) is a shrub native to North America which has been Edited by: Kalin Yanbo Zhang, cultivated mainly for its ornamental features, honey plant value and protective properties University of Hong Kong, Hong Kong against soil erosion. -
And S-Equol and Implication of Transactivation Functions (AF-1 and AF-2) in Estrogen Receptor-Induced Transcriptional Activity
Nutrients 2010, 2, 340-354; doi:10.3390/nu2030340 OPEN ACCESS nutrients ISSN 2072-6643 www.mdpi.com/journal/nutrients Communication Comparative Effects of R- and S-equol and Implication of Transactivation Functions (AF-1 and AF-2) in Estrogen Receptor-Induced Transcriptional Activity Svitlana Shinkaruk 1, Charlotte Carreau 1, Gilles Flouriot 2, Catherine Bennetau-Pelissero 1 and Mylène Potier 1,* 1 ENITA de Bordeaux, Unité Micronutriments Reproduction Santé, 1 Cours du Général de Gaulle, CS 40201, F-33175 Gradignan cedex, France; E-Mails: [email protected] (S.S); [email protected] (C.C.); [email protected] (C.B.-P.); 2 CNRS UMR 6026, 35042, Equipe "Récepteur des œstrogènes et destinée cellulaire", Rennes cedex, France; E-Mail: [email protected] * Author to whom correspondence should be addressed: E-Mail: [email protected]. Received: 4 January 2010; in revised form: 20 February 2010 / Accepted: 25 February 2010 / Published: 15 March 2010 Abstract: Equol, one of the main metabolites of daidzein, is a chiral compound with pleiotropic effects on cellular signaling. This property may induce activation/inhibition of the estrogen receptors (ER) or and therefore, explain the beneficial/deleterious effects of equol on estrogen-dependent diseases. With its asymmetric centre at position C-3, equol can exist in two enantiomeric forms (R- and S-equol). To elucidate the yet unclear mechanisms of ER activation/inhibition by equol, we performed a comprehensive analysis of ER and ER transactivation by racemic equol, as well as by enantiomerically pure forms. Racemic equol was prepared by catalytic hydrogenation from daidzein and separated into enantiomers by chiral HPLC. -
Neuroprotective Mechanisms of Red Clover and Soy Isoflavones in Parkinson’S Disease Models
bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted January 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson’s disease models Aurélie de Rus Jacquet1,2*, Abeje Ambaw3,4, Mitali Arun Tambe1,5, Sin Ying Ma1, Michael Timmers6,7, Qing-Li Wu8, James E. Simon8, George P. McCabe9, Mary Ann Lila6, Riyi Shi3,10,11, Jean-Christophe Rochet1,11*. 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA 2Present affiliations: Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, QC, G1V 4G2, Canada, and Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, G1V 0A6, Canada 3Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA 4Present affiliation: Physiology Department, Monterey Peninsula College, Monterey, CA, 93940, USA. 5Present affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA 6Plants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, 28081, USA 7Present affiliation: Berry Blue, Kannapolis, NC, 28081, USA 8Department of Plant Biology, Rutgers University, New Brunswick, NJ, 08901, USA 9Department of Statistics, Purdue University, West Lafayette, IN 47907, USA 10Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA 11Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA * Corresponding authors: Jean-Christophe Rochet: [email protected] Aurélie de Rus Jacquet: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted January 1, 2021. -
Bioactive Fractions and Compounds from Dalbergia
(19) TZZ ZZ_T (11) EP 2 705 047 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C07H 17/07 (2006.01) A61K 31/7048 (2006.01) 05.08.2015 Bulletin 2015/32 C07D 311/36 (2006.01) A61K 31/352 (2006.01) A61P 19/10 (2006.01) (21) Application number: 12729239.9 (86) International application number: (22) Date of filing: 25.04.2012 PCT/IN2012/000301 (87) International publication number: WO 2012/147102 (01.11.2012 Gazette 2012/44) (54) BIOACTIVE FRACTIONS AND COMPOUNDS FROM DALBERGIA SISSOO FOR THE PREVENTION OR TREATMENT OF OSTEO-HEALTH RELATED DISORDERS BIOAKTIVE FRAKTIONEN UND VERBINDUNGEN AUS DALBERGIA SISSOO ZUR VORBEUGUNG ODER BEHANDLUNG KNOCHENZUSTANDSBEDINGTER ERKRANKUNGEN FRACTIONS ET COMPOSÉS BIOACTIFS ISSUS DE DALBERGIA SISSOO POUR PRÉVENIR OU TRAITER LES TROUBLES D’ORIGINE OSTÉOPATHIQUE (84) Designated Contracting States: • WAHAJUDDIN AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Lucknow 226001 (IN) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • JAIN, Girish, Kumar PL PT RO RS SE SI SK SM TR Lucknow 226001 (IN) • CHATTOPADHYAY, Naibedya (30) Priority: 25.04.2011 IN DE12062011 Lucknow 226001 (IN) (43) Date of publication of application: (74) Representative: Jakobsson, Jeanette Helene 12.03.2014 Bulletin 2014/11 Awapatent AB P.O. Box 5117 (73) Proprietor: Council of Scientific & Industrial 200 71 Malmö (SE) Research New Delhi 110 001 (IN) (56) References cited: WO-A2-00/62765 WO-A2-2007/042010 (72) Inventors: FR-A1- 2 483 228 • MAURYA, Rakesh Lucknow 226001 (IN) • PREETY DIXIT ET AL: "Constituents of Dalbergia • DIXIT, Preety sissoo Roxb. -
Phytochemical Investigation of Three Leguminosae Plants for Cancer Chemopreventive Agents
UNIVERSITY OF NAIROBI COLLEGE OF BIOLOGICAL AND PHYSICAL SCIENCES DEPARTMENT OF CHEMISTRY PHYTOCHEMICAL INVESTIGATION OF THREE LEGUMINOSAE PLANTS FOR CANCER CHEMOPREVENTIVE AGENTS BY IVAN GUMULA A THESIS SUBMITTED IN FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF DOCTOR OF PHILOSOPHY (PhD) IN CHEMISTRY OF THE UNIVERSITY OF NAIROBI 2014 ii DEDICATION This work is dedicated to my family iii ACKNOWLEDGEMENTS First of all, I would like to thank the University of Nairobi for admitting me as a Doctoral student. I wish to extend my heartfelt gratitude to my supervisors; Prof. Abiy Yenesew, Dr. Solomon Derese and Prof. Isaiah O. Ndiege whose close supervision coupled with resourceful guidance/advice enriched me with the knowledge, skills and attitude resulting in the success of this research. I am grateful to the German Academic Exchange Services (DAAD) and the Natural Products Research Network for Eastern and Central Africa (NAPRECA) for financial support during my studies. I appreciate the help extended to me by Dr. Matthias Heydenreich of the University of Potsdam in spectroscopic/spectrometric analyses of some of the compounds reported in this thesis. Special thanks go to the Swedish Institute for sponsoring my research visit to the University of Gothenburg. I am indebted to my host supervisor, Prof. Máté Erdélyi, and the Halogen Bond Research Group of the Department of Chemistry and Molecular Biology, at the University of Gothenburg for his unwavering support and guidance in isolation and spectroscopic techniques and analysis. My sincere gratitude is extended to Dr. John P. Alao and Prof. Per Sunnerhagen of the Department of Chemistry and Molecular Biology at the University of Gothenburg for carrying out cytotoxicity assays. -
Natural Products As Chemopreventive Agents by Potential Inhibition of the Kinase Domain in Erbb Receptors
Supplementary Materials: Natural Products as Chemopreventive Agents by Potential Inhibition of the Kinase Domain in ErBb Receptors Maria Olivero-Acosta, Wilson Maldonado-Rojas and Jesus Olivero-Verbel Table S1. Protein characterization of human HER Receptor structures downloaded from PDB database. Recept PDB resid Resolut Name Chain Ligand Method or Type Code ues ion Epidermal 1,2,3,4-tetrahydrogen X-ray HER 1 2ITW growth factor A 327 2.88 staurosporine diffraction receptor 2-{2-[4-({5-chloro-6-[3-(trifl Receptor uoromethyl)phenoxy]pyri tyrosine-prot X-ray HER 2 3PP0 A, B 338 din-3-yl}amino)-5h-pyrrolo 2.25 ein kinase diffraction [3,2-d]pyrimidin-5-yl]etho erbb-2 xy}ethanol Receptor tyrosine-prot Phosphoaminophosphonic X-ray HER 3 3LMG A, B 344 2.8 ein kinase acid-adenylate ester diffraction erbb-3 Receptor N-{3-chloro-4-[(3-fluoroben tyrosine-prot zyl)oxy]phenyl}-6-ethylthi X-ray HER 4 2R4B A, B 321 2.4 ein kinase eno[3,2-d]pyrimidin-4-ami diffraction erbb-4 ne Table S2. Results of Multiple Alignment of Sequence Identity (%ID) Performed by SYBYL X-2.0 for Four HER Receptors. Human Her PDB CODE 2ITW 2R4B 3LMG 3PP0 2ITW (HER1) 100.0 80.3 65.9 82.7 2R4B (HER4) 80.3 100 71.7 80.9 3LMG (HER3) 65.9 71.7 100 67.4 3PP0 (HER2) 82.7 80.9 67.4 100 Table S3. Multiple alignment of spatial coordinates for HER receptor pairs (by RMSD) using SYBYL X-2.0. Human Her PDB CODE 2ITW 2R4B 3LMG 3PP0 2ITW (HER1) 0 4.378 4.162 5.682 2R4B (HER4) 4.378 0 2.958 3.31 3LMG (HER3) 4.162 2.958 0 3.656 3PP0 (HER2) 5.682 3.31 3.656 0 Figure S1. -
Glyceollin) in Soybeans and Pullulan from Sucrose
South Dakota State University Open PRAIRIE: Open Public Research Access Institutional Repository and Information Exchange Electronic Theses and Dissertations 2020 Developing Microbial Based Process to Produce High Value Natural Antimicrobial (Glyceollin) in Soybeans and Pullulan from Sucrose Andrea Zavadil South Dakota State University Follow this and additional works at: https://openprairie.sdstate.edu/etd Part of the Agronomy and Crop Sciences Commons, Environmental Microbiology and Microbial Ecology Commons, and the Plant Biology Commons Recommended Citation Zavadil, Andrea, "Developing Microbial Based Process to Produce High Value Natural Antimicrobial (Glyceollin) in Soybeans and Pullulan from Sucrose" (2020). Electronic Theses and Dissertations. 5002. https://openprairie.sdstate.edu/etd/5002 This Thesis - Open Access is brought to you for free and open access by Open PRAIRIE: Open Public Research Access Institutional Repository and Information Exchange. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of Open PRAIRIE: Open Public Research Access Institutional Repository and Information Exchange. For more information, please contact [email protected]. DEVELOPING MICROBIAL BASED PROCESS TO PRODUCE HIGH VALUE NATURAL ANTIMICROBIAL (GLYCEOLLIN) IN SOYBEANS AND PULLULAN FROM SUCROSE BY ANDREA ZAVADIL A thesis submitted in partial fulfillment of the requirements for the Master of Science Major in Biological Sciences Specialization in Microbiology South Dakota State University 2020 ii THESIS ACCEPTANCE PAGE Andrea Zavadil This thesis is approved as a creditable and independent investigation by a candidate for the master’s degree and is acceptable for meeting the thesis requirements for this degree. Acceptance of this does not imply that the conclusions reached by the candidate are necessarily the conclusions of the major department. -
Genetic Regulation of the Elicitation of Glyceollin Biosynthesis in Soybean
Graduate Theses, Dissertations, and Problem Reports 2019 GENETIC REGULATION OF THE ELICITATION OF GLYCEOLLIN BIOSYNTHESIS IN SOYBEAN Md. Asraful Jahan West Virginia University, [email protected] Follow this and additional works at: https://researchrepository.wvu.edu/etd Part of the Agricultural Science Commons, Genetics Commons, Molecular Genetics Commons, Plant Breeding and Genetics Commons, and the Plant Pathology Commons Recommended Citation Jahan, Md. Asraful, "GENETIC REGULATION OF THE ELICITATION OF GLYCEOLLIN BIOSYNTHESIS IN SOYBEAN" (2019). Graduate Theses, Dissertations, and Problem Reports. 3782. https://researchrepository.wvu.edu/etd/3782 This Dissertation is protected by copyright and/or related rights. It has been brought to you by the The Research Repository @ WVU with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you must obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Dissertation has been accepted for inclusion in WVU Graduate Theses, Dissertations, and Problem Reports collection by an authorized administrator of The Research Repository @ WVU. For more information, please contact [email protected]. Genetic Regulation of the Elicitation of Glyceollin Biosynthesis in Soybean Md. Asraful Jahan Dissertation submitted to the Davis College of Agriculture, Natural Resources and Design at West Virginia University in partial fulfillment of requirements for the degree of Doctor of Philosophy in Genetics and Developmental Biology Nikola Kovinich, Ph.D., Committee Chair Daniel G. -
Introduction (Pdf)
Dictionary of Natural Products on CD-ROM This introduction screen gives access to (a) a general introduction to the scope and content of DNP on CD-ROM, followed by (b) an extensive review of the different types of natural product and the way in which they are organised and categorised in DNP. You may access the section of your choice by clicking on the appropriate line below, or you may scroll through the text forwards or backwards from any point. Introduction to the DNP database page 3 Data presentation and organisation 3 Derivatives and variants 3 Chemical names and synonyms 4 CAS Registry Numbers 6 Diagrams 7 Stereochemical conventions 7 Molecular formula and molecular weight 8 Source 9 Importance/use 9 Type of Compound 9 Physical Data 9 Hazard and toxicity information 10 Bibliographic References 11 Journal abbreviations 12 Entry under review 12 Description of Natural Product Structures 13 Aliphatic natural products 15 Semiochemicals 15 Lipids 22 Polyketides 29 Carbohydrates 35 Oxygen heterocycles 44 Simple aromatic natural products 45 Benzofuranoids 48 Benzopyranoids 49 1 Flavonoids page 51 Tannins 60 Lignans 64 Polycyclic aromatic natural products 68 Terpenoids 72 Monoterpenoids 73 Sesquiterpenoids 77 Diterpenoids 101 Sesterterpenoids 118 Triterpenoids 121 Tetraterpenoids 131 Miscellaneous terpenoids 133 Meroterpenoids 133 Steroids 135 The sterols 140 Aminoacids and peptides 148 Aminoacids 148 Peptides 150 β-Lactams 151 Glycopeptides 153 Alkaloids 154 Alkaloids derived from ornithine 154 Alkaloids derived from lysine 156 Alkaloids