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A Research Agenda for DSM-V

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A Research Agenda for DSM-V A Research Agenda for DSM-V A Research Agenda for DSM-V Edited by David J. Kupfer, M.D. Michael B. First, M.D. Darrel A. Regier, M.D., M.P.H. Published by the American Psychiatric Association Washington, D.C. Note: The authors have worked to ensure that all information in this book is accu- rate at the time of publication and consistent with general psychiatric and medical standards, and that information concerning drug dosages, schedules, and routes of administration is accurate as of the time of publication and consistent with stan- dards set by the U.S. Food and Drug Administration and the general medical com- munity. As medical research and practice continue to advance, however, therapeutic standards may change. Moreover, specific situations may require a spe- cific therapeutic response not included in this book. For these reasons and because human and mechanical errors sometimes occur, we recommend that readers follow the advice of physicians directly involved in their care or the care of a member of their family. The findings, opinions, and conclusions of this report do not necessarily represent the views of the officers, trustees, or all members of the American Psychiatric Asso- ciation. The views expressed are those of the authors of the individual chapters. Typeset in Adobe's Janson Text and Frutiger Copyright ã 2002 American Psychiatric Association ALL RIGHTS RESERVED Manufactured in the United States of America on acid-free paper 06 05 04 03 02 5 4 3 2 1 First Edition American Psychiatric Association 1400 K Street, N.W., Washington, DC 20005 www.psych.org Library of Congress Cataloging-in-Publication Data A research agenda for DSM-V / edited by David J. Kupfer, Michael B. First, Darrel A. Regier.— 1st ed. p. ; cm. Includes bibliographical references and index. ISBN 0-89042-292-3 (alk. paper) 1. Diagnostic and statistical manual of mental disorders. 2. Mental illness— Diagnosis. 3. Mental illness—Classification. I. Kupfer, David J., 1941- II. First, Michael B., 1956- III. Regier, Darrel A. IV. Dagnostic and statistical manual of mental disor- ders. [DNLM: 1. Mental Disorders—diagnosis. 2. Research. WM 141 R432 2002] RC455.2.C4 R463 2002 616.89¢075—dc21 2002021556 British Library Cataloguing in Publication Data A CIP record is available from the British Library. Contents Contributors . .vii Acknowledgments . xiii Introduction . xv David J. Kupfer, M.D., Michael B. First, M.D., Darrel E. Regier, M.D., M.P.H. 1 Basic Nomenclature Issues for DSM-V . 1 Bruce J. Rounsaville, M.D., Renato D. Alarcón, M.D., M.P.H., Gavin Andrews, M.D., James S. Jackson, Ph.D., Robert E. Kendell, M.D., Kenneth Kendler, M.D. 2 Neuroscience Research Agenda to Guide Development of a Pathophysiologically Based Classification System . 31 Dennis S. Charney, M.D., David H. Barlow, Ph.D., Kelly Botteron, M.D., Jonathan D. Cohen, M.D., David Goldman, M.D., Raquel E. Gur, M.D., Ph.D., Keh-Ming Lin, M.D., M.P.H., Juan F. López, M.D., James H. Meador-Woodruff, M.D., Steven O. Moldin, Ph.D., Eric J. Nestler, M.D., Ph.D., Stanley J. Watson, M.D., Ph.D., Steven J. Zalcman, M.D. 3 Advances in Developmental Science and DSM-V . 85 Daniel S. Pine, M.D., Margarita Alegria, Ph.D., Edwin H. Cook Jr., M.D., E. Jane Costello, Ph.D., Ronald E. Dahl, M.D., Doreen Koretz, Ph.D., Kathleen R. Merikangas, Ph.D., Allan L. Reiss, M.D., Benedetto Vitiello, M.D. 4 Personality Disorders and Relational Disorders: A Research Agenda for Addressing Crucial Gaps in DSM . 123 Michael B. First, M.D., Carl C. Bell, M.D., Bruce Cuthbert, Ph.D., John H Krystal, M.D., Robert Malison, M.D., David R. Offord, M.D., David Reiss, M.D., M. Tracie Shea, Ph.D., Tom Widiger, Ph.D., Katherine L. Wisner, M.D., M.S. 5 Mental Disorders and Disability: Time to Reevaluate the Relationship? . 201 Anthony F. Lehman, M.D., M.S.P.H., George S. Alexopoulos, M.D., Howard Goldman, M.D., Ph.D., Dilip Jeste, M.D., Bedirhan Üstün, M.D. 6 Beyond the Funhouse Mirrors: Research Agenda on Culture and Psychiatric Diagnosis . 219 Renato D. Alarcón, M.D., M.P.H., Margarita Alegria, Ph.D., Carl C. Bell, M.D., Cheryl Boyce, Ph.D., Laurence J. Kirmayer, M.D., Keh-Ming Lin, M.D., M.P.H., Steven Lopez, Ph.D., Bedirhan Üstün, M.D., Katherine L. Wisner, M.D., M.S. Appendix 6–1 Preliminary List of Suggested Areas and Topics of Research in Culture and Psychiatric Diagnosis . 283 Index . 291 Contributors Renato D. Alarcón, M.D., M.P.H. Professor and Vice-Chairman, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine; Chief, Mental Health Service Line, Atlanta Department of Veterans Affairs Medical Center, At- lanta, Georgia Margarita Alegria, Ph.D. Professor of Health Services Administration; Director of the Center for Evaluation and Sociomedical Research, University of Puerto Rico, San Juan, Puerto Rico George S. Alexopoulos, M.D. Professor, Department of Psychiatry, The New York Hospital, Cornell Medical Center, Westchester Division, White Plains, New York Gavin Andrews, M.D. Professor, School of Psychiatry, University of New South Wales at St. Vin- cent’s Hospital, Anxiety Disorders Unit, Darlinghurst, New South Wales, Australia David H. Barlow, Ph.D. Professor, Center for Adaptive Systems, Department of Psychology, Bos- ton University, Boston, Massachusetts Carl C. Bell, M.D. President/CEO, Community Mental Health Council/Foundation, Inc.; Professor of Psychiatry, Department of Psychiatry, School of Medicine, and Professor of Public Health, School of Public Health, University of Il- linois at Chicago, Chicago, Illinois Kelly Botteron, M.D. Assistant Professor, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri Cheryl Boyce, Ph.D. Chief, Sociocultural Processes and Health Disparities Program, Develop- mental Psychopathology and Prevention Research Program, National In- stitute of Mental Health, Bethesda, Maryland vii viii A RESEARCH AGENDA FOR DSM-V Dennis S. Charney, M.D. Chief, Mood and Anxiety Disorders Research Program, National Institute of Mental Health, Bethesda, Maryland Jonathan D. Cohen, M.D. Professor, Department of Psychology; Director, Center for Study of Brain, Mind and Behavior, Princeton University, Princeton, New Jersey; Profes- sor, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Penn- sylvania Edwin H. Cook Jr., M.D. Professor of Psychiatry and Pediatrics, Department of Child and Adoles- cent Psychiatry, University of Chicago, Chicago, Illinois E. Jane Costello, Ph.D. Professor, Department of Psychiatry and Behavioral Sciences, Duke Uni- versity Medical Center, Durham, North Carolina Bruce Cuthbert, Ph.D. Chief, Adult Psychopathology and Prevention Research Branch, Division of Mental Disorders, Behavioral Research and AIDS, National Institute of Mental Health, Bethesda, Maryland Ronald E. Dahl, M.D. Associate Professor of Psychiatry and Pediatrics, Western Psychiatric In- stitute and Clinic, Pittsburgh, Pennsylvania Michael B. First, M.D. Research Psychiatrist, New York State Psychiatric Institute; Associate Pro- fessor of Clinical Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York David Goldman, M.D. Chief, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland Howard Goldman, M.D., Ph.D. Professor, Department of Psychiatry, University of Maryland, Baltimore, Maryland Raquel E. Gur, M.D., Ph.D. Professor, Director of Neuropsychiatry, Departments of Psychiatry, Neu- rology, and Radiology, University of Pennsylvania, Philadelphia, Pennsyl- vania Contributors ix James S. Jackson, Ph.D. Daniel Katz Distinguished University Professor of Psychology, College of Literature, Science, and the Arts; Professor of Health Behavior and Health Education, School of Public Health; and Director and Research Scientist, Research Center for Group Dynamics, Institute for Social Research, Uni- versity of Michigan, Ann Arbor, Michigan Dilip Jeste, M.D. Professor, University of California San Diego, Department of Veterans’ Affairs San Diego Healthcare System, San Diego, California Robert E. Kendell, M.D. Professor, University Department of Psychiatry, Royal Edinburgh Hospi- tal, Edinburgh, Scotland Kenneth Kendler, M.D. Professor, Department of Psychiatry and Human Genetics, Medical Col- lege of Virginia, Virginia Commonwealth University and Virginia Insti- tute for Psychiatric and Behavioral Genetics, Richmond, Virginia Laurence J. Kirmayer, M.D. Professor, Department of Psychiatry, and Director, Division of Social and Transcultural Psychiatry, McGill University, Montreal, Quebec, Canada Doreen Koretz, Ph.D. Associate Director for Prevention, Division of Mental Disorders, Behav- ioral Research and AIDS, National Institute of Mental Health, Bethesda, Maryland John H. Krystal, M.D. Albert E. Kent Professor and Deputy Chairman for Research, Department of Psychiatry, Yale University School of Medicine, New Haven, and Psy- chiatry Service, Veterans’ Administration Connecticut Health System, West Haven, Connecticut David J. Kupfer, M.D. Thomas Detre Professor and Chair, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania x A RESEARCH AGENDA FOR DSM-V Anthony F. Lehman, M.D., M.S.P.H. Professor and Chair, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland Keh-Ming Lin, M.D., M.P.H. Professor, Department of Psychiatry, School of Medicine, University of California at Los Angeles; Director, Research Center on the Psychobiol- ogy of Ethnicity, Harbor–University of
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