Figure S1. Rhod 2 staining of intracellular calcium depletion. Confocal microscopy bright field and fluorescent images x20 magnification of one UMM (OMM2.3) and one CMM (A375) line after staining with 1 µM Rhod 2 and 48 h of treatment with 0, 1, 3 and 8 µM amlodipine. UMM, uveal malignant melanoma; CMM, cutaneous malignant melanoma. Figure S2. Spheroid colonies. Light microscopy x5 magnification images of 3D spheroid colonies in CMM and UMM lines. Images were acquired just prior to the addition of 20 µM amlodipine in the treated groups or an equivalent volume of DMSO in control groups (Day 0). The same colonies were then visualized again after 48 h of treatment (Day 2). UMM, uveal malignant melanoma; CMM, cutaneous malignant melanoma. Figure S3. Senescence assay for amlodipine-induced cell death. Light microscopy x20 magnification images of CMM (A375, CHL-1 and IPC298) and UMM (MP41) lines when treated with amlodipine at 3 dose points over a 48-h period. Senescence is indicated with blue dye. UMM, uveal malignant melanoma; CMM, cutaneous malignant melanoma. Table SI. High-throughput drug screening compounds: Ranked list of the 1,018 screened compounds based on observed proliferation ratio. Rank Proliferation Compound ratio 1 0.00000 Fluoxetine HCl 2 0.00042 Amlodipine (Norvasc) 3 0.00042 Dronedarone HCl (Multaq) 4 0.00049 Prochlorperazine dimaleate 5 0.00055 Afatinib (BIBW2992) 7 0.00055 AMG-073 HCl (cinacalcet hydrochloride) 8 0.00055 Amlodipine besylate (Norvasc) 6 0.00055 Crizotinib (PF-02341066) 9 0.00064 Crystal violet 10 0.00074 Alexidine HCl 11 0.00074 Benzethonium chloride 14 0.00074 Cetrimonium bromide 13 0.00074 Domiphen bromide 15 0.00074 Thioridazine HCl 12 0.00074 Trifluoperazine 2HCl 16 0.00083 Bosutinib (SKI-606) 17 0.00085 Mitoxantrone hydrochloride 18 0.00085 Duloxetine HCl (Cymbalta) 19 0.00099 Cetylpyridinium chloride 20 0.00099 Thonzonium bromide 21 0.00106 Paroxetine HCl 22 0.00106 Carfilzomib (PR-171) 23 0.00110 Nebivolol (Bystolic) 24 0.00124 Nelfinavir mesylate 25 0.00124 Triflupromazine HCl 26 0.00127 Daunorubicin HCl (Daunomycin HCl) 27 0.00138 Doxorubicin (Adriamycin) 28 0.00149 Sertraline HCl 29 0.00169 Bazedoxifene HCl 30 0.00170 Loperamide hydrochloride 31 0.00173 Penfluridol 32 0.00193 Bortezomib (Velcade) 33 0.00197 9-Aminoacridine 34 0.00220 Epirubicin hydrochloride 35 0.00233 Aliskiren hemifumarate 37 0.00234 Chlorpromazine (Sonazine) 38 0.00234 Maprotiline hydrochloride 36 0.00234 Menadione 39 0.00247 Ouabain 40 0.00247 Sunitinib malate (Sutent) 41 0.00271 Cepharanthine 42 0.00271 Terfenadine 43 0.00321 Emetine 44 0.00519 Nitarsone 45 0.00568 Digoxigenin 46 0.00692 Clemastine fumarate 47 0.00741 Disulfiram (Antabuse) 48 0.01042 Clomipramine hydrochloride (Anafranil) 49 0.01048 Adefovir Dipivoxil (Preveon, Hepsera) 50 0.01212 Vinorelbine tartrate 51 0.01356 Proadifen HCl 52 0.01381 Clomifene citrate (Serophene) 53 0.01603 Thiostrepton 54 0.01762 Ethacridine lactate monohydrate 55 0.02190 Toremifene citrate (Fareston, Acapodene) 56 0.02229 Vorinostat (SAHA) 57 0.02435 Topotecan HCl 58 0.02618 Lomerizine HCl 59 0.02850 Ivacaftor (VX-770) 60 0.03878 Camptothecin 61 0.04406 Ziprasidone hydrochloride 62 0.04793 Sorafenib (Nexavar) 63 0.05525 Pyrithione zinc 64 0.05687 Ticagrelor 65 0.05819 Masitinib (AB1010) 66 0.09668 Meclocycline sulfosalicylate 67 0.11141 Asenapine 68 0.12470 Indacaterol maleate 69 0.13885 Carvedilol 70 0.13952 Primaquine diphosphate 71 0.13963 Bleomycin sulfate 72 0.15462 Imatinib Mesylate 73 0.15497 Solifenacin succinate 74 0.15876 Amitriptyline HCl 75 0.15924 R-(-)-Apomorphine HCl hemihydrate 76 0.18245 Pitavastatin calcium (Livalo) 77 0.20079 Ivermectin 78 0.20520 Desloratadine 79 0.20598 Pentamidine 80 0.20982 Aprepitant (MK-0869) 81 0.22060 Dapoxetine hydrochloride (Priligy) 82 0.22252 Cilnidipine 83 0.23689 Nifuroxazide 84 0.23974 Lonidamine 85 0.24045 Gemcitabine (Gemzar) 86 0.24876 Elvitegravir (GS-9137) 87 0.25162 Doxycycline HCl 88 0.25189 Cephalomannine 89 0.25404 Fenoprofen calcium 90 0.26206 Teniposide (Vumon) 91 0.26917 Chlorpheniramine maleate 92 0.27078 Tenofovir disoproxil Fumarate 93 0.29291 Riluzole (Rilutek) 94 0.29338 Mycophenolic (Mycophenolate) 95 0.29350 Evista (Raloxifene hydrochloride) 96 0.29821 XL-184 (Cabozantinib) 97 0.30870 Vinblastine 98 0.31176 Nisoldipine (Sular) 99 0.31183 Simvastatin (Zocor) 100 0.31240 Azacitidine (Vidaza) 101 0.32977 Pizotifen malate 102 0.33260 Albendazole oxide (Ricobendazole) 103 0.33269 Procodazole 104 0.33805 Azaguanine-8 105 0.34341 Lamivudine (Epivir) 106 0.34524 Ciclopirox (Penlac) 107 0.34591 Fluvoxamine maleate 108 0.35166 Clofarabine 109 0.35722 Valnemulin HCl 110 0.35954 Azelastine hydrochloride (Astelin) 111 0.36185 Licofelone 112 0.36509 Rotigotine 113 0.36512 Cladribine 114 0.36527 Darifenacin HBr 115 0.36631 Celecoxib 116 0.36805 Diperodon HCl 117 0.37690 L-Adrenaline (Epinephrine) 118 0.37842 Ciclopirox ethanolamine 119 0.38325 Nitazoxanide (Alinia, Annita) 120 0.38568 Acemetacin (Emflex) 121 0.39396 Trimipramine maleate 122 0.39694 Vincristine 123 0.40995 Coumarin 124 0.41325 Dasatinib (BMS-354825) 125 0.41573 Etravirine (TMC125) 126 0.41657 Doxazosin mesylate 127 0.42478 Cabazitaxel (Jevtana) 128 0.42821 Albendazole (Albenza) 129 0.43579 Chlorprothixene 130 0.43960 Lapatinib Ditosylate (Tykerb) 131 0.44312 Etoposide (VP-16) 132 0.44600 OSI-420 (Desmethyl erlotinib) 133 0.45329 Mycophenolate mofetil (CellCept) 134 0.45508 Miconazole nitrate 135 0.45794 Erlotinib HCl 136 0.46496 Pimobendan (Vetmedin) 137 0.47266 Lopinavir (ABT-378) 138 0.49230 Atorvastatin calcium (Lipitor) 139 0.49668 Domperidone (Motilium) 140 0.50606 Pazopanib HCl 141 0.50713 Clotrimazole (Canesten) 142 0.50750 Anisindione 143 0.50955 Fenbendazole (Panacur) 144 0.51170 Idarubicin HCl 145 0.51598 Benserazide 146 0.51712 Monobenzone (Benoquin) 147 0.51961 Irinotecan HCl trihydrate (Campto) 148 0.52007 Fludarabine (Fludara) 149 0.52252 Catharanthine 150 0.53186 Guanabenz acetate 151 0.53343 Nicardipine HCl 152 0.53592 Propafenone (Rytmonorm) 153 0.53665 Oxethazaine 154 0.53820 Deferasirox (Exjade) 155 0.54810 Fluvastatin sodium (Lescol) 156 0.55240 Carbidopa 157 0.55688 Tamoxifen citrate (Nolvadex) 158 0.56146 Clofoctol 159 0.56674 Fludarabine phosphate (Fludara) 160 0.57685 Imipramine HCl 161 0.57921 Irinotecan 162 0.58316 Resveratrol 163 0.58708 Chloroxine 164 0.58754 Trifluridine (Viroptic) 165 0.58785 Tacrine HCl 166 0.59079 2-Methoxyestradiol 167 0.59196 Tolcapone 168 0.59902 Econazole nitrate (Spectazole) 169 0.60221 Oxaliplatin (Eloxatin) 170 0.60308 Eltrombopag (SB-497115-GR) 171 0.60500 Paclitaxel (Taxol) 172 0.60974 Tigecycline 173 0.61596 Ethinyl Estradiol 174 0.61637 Brucine 175 0.61657 Benidipine hydrochloride 176 0.61796 10-DAB (10-Deacetylbaccatin) 177 0.61920 Ketoconazole 178 0.61991 Tolterodine tartrate (Detrol LA) 179 0.62391 Dicyclomine HCl 180 0.62849 Cyproheptadine HCl (Periactin) 181 0.62937 Phenazopyridine HCl 182 0.63254 Bufexamac 183 0.63641 Ulipristal 184 0.64024 Isoetharine mesylate 185 0.64187 Ospemifene 186 0.65023 Sulconazole nitrate 187 0.65218 Docetaxel (Taxotere) 188 0.65646 Oxytetracycline (Terramycin) 189 0.65812 Fenticonazole nitrate 190 0.66034 Ritonavir 191 0.66217 Benzydamine hydrochloride 192 0.66512 Imidapril (Tanatril) HCl 193 0.66684 Idoxuridine 194 0.66777 Miconazole (Monistat) 195 0.67937 Manidipine (Manyper) 196 0.68048 Axitinib 197 0.68169 Floxuridine 198 0.68281 Chlorquinaldol 199 0.70334 Cisatracurium besylate (Nimbex) 200 0.71341 Ivabradine HCl (Procoralan) 201 0.72356 Mesoridazine besylate 202 0.73867 Atazanavir sulfate 203 0.74086 Loratadine 204 0.74200 Nitrofurazone (Nitrofural) 205 0.74507 Imatinib (Gleevec) 206 0.74830 Fidaxomicin 207 0.75269 Hydroxyzine 2HCl 208 0.75730 Arbidol HCl 209 0.75825 Quinine hydrochloride dihydrate 210 0.75982 Dibucaine HCL 211 0.76361 Gefitinib (Iressa) 212 0.76433 Nifedipine (Adalat) 213 0.76709 Meticrane 214 0.76796 Atracurium besylate 215 0.76961 Deoxyarbutin 216 0.77569 Thiabendazole 217 0.78225 Phentolamine mesilate 218 0.78355 Formoterol hemifumarate 219 0.78515 Azelnidipine 220 0.78897 Progesterone (Prometrium) 221 0.79385 Tioconazole 222 0.79787 BIBR-1048 (Dabigatran) 223 0.79839 Naftopidil (Flivas) 224 0.79949 Exemestane 225 0.80059 Ezetimibe (Zetia) 226 0.80144 Fenoprofen calcium hydrate 227 0.80162 Methazolamide 228 0.80200 Rimonabant (SR141716) 229 0.80972 Quinapril HCl (Accupril) 230 0.81385 Regorafenib (BAY 73-4506) 231 0.82073 Flunarizine 2HCl 232 0.82128 Clozapine (Clozaril) 233 0.82618 Cobicistat (GS-9350) 234 0.82656 Curcumin 235 0.83127 Ranitidine (Zantac) 236 0.83376 Tolperisone HCl 237 0.83788 Mianserin hydrochloride 238 0.83835 Diphenylpyraline HCl 239 0.84359 Alprostadil (Caverject) 240 0.84467 Pramiracetam 241 0.85274 Broxyquinoline 242 0.85420 Estradiol 243 0.85457 Clorgyline HCl 244 0.85579 Benztropine mesylate 245 0.86009 Scopolamine hydrobromide 246 0.86178 Levosimendan 247 0.86179 Epinephrine bitartrate (Adrenalinium) 248 0.86669 Serotonin HCl 249 0.87069 Budesonide 250 0.87180 Alverine Citrate 251 0.87755 Rimantadine (Flumadine) 252 0.88126 Terbinafine hydrochloride (Lamisil) 253 0.88370 Scopine 254 0.88499 Carmofur 255 0.88530 Conivaptan HCl (Vaprisol) 256 0.88551 Mifepristone (Mifeprex) 257 0.88611 Tetracycline HCl 258 0.88968 Ethoxzolamide 259 0.89124 Noscapine HCl 260 0.89630 Methacycline hydrochloride (Physiomycine) 261 0.89960 Oxybuprocaine HCl 262 0.90202 Tiotropium bromide hydrate 263 0.90270 Triclabendazole 264 0.90285 Temsirolimus (Torisel) 265 0.90419 Adrucil (Fluorouracil) 266 0.90446 Nilvadipine (ARC029) 267 0.90585 Clinafoxacin HCl 268 0.90610 Sucralose 269 0.90797 Butoconazole nitrate 270 0.90879 Silodosin (Rapaflo) 271 0.90997 Tebipenem pivoxil (L-084) 272 0.91016 Isoconazole nitrate (Travogen) 273 0.91108 Sulfadiazine 274 0.91210 Dichlorisone acetate 275 0.91225 Pyrimethamine 276 0.91242 Iloperidone (Fanapt) 277 0.91341 Estradiol cypionate 278 0.91358 triamterene 279 0.91545 Furaltadone HCl 280 0.91563 Lincomycin hydrochloride (Lincocin) 281 0.91578 Saxagliptin (BMS-477118,Onglyza) 282 0.91673 Sotalol (Betapace) 283 0.91693 Nitrendipine 284 0.91852 Buflomedil HCl 285 0.91931 Rolitetracycline 286 0.92114 Picrotoxinin 287 0.92319 Everolimus (RAD001) 288 0.92456 Rapamycin (Sirolimus) 289 0.92524 Rifapentine (Priftin) 290 0.92823 Decitabine 291 0.92912 Ranolazine (Ranexa) 292 0.92932 Acetarsone 293 0.93004 Bendamustine HCL 294 0.93160 Reserpine 295 0.93282 Dyclonine HCl 296 0.93369 PCI-32765 (Ibrutinib) 297 0.93405 Dexmedetomidine 298 0.93450 Nimodipine (Nimotop) 299 0.93466 Liothyronine sodium 300 0.93779 Vismodegib (GDC-0449) 301 0.93821 Ipratropium bromide 302 0.93822 Trospium chloride (Sanctura) 303 0.93825 Vildagliptin (LAF-237) 304 0.93925 Tilmicosin 305 0.93994 Azatadine dimaleate 306 0.94013 Bosentan 307 0.94132 Pridinol methanesulfonate 308 0.94179 Reboxetine mesylate 309 0.94332 Loxapine succinate 310 0.94726 Benzthiazide 311 0.94727 Pravastatin sodium 312 0.94742 Dopamine hydrochloride (Inotropin) 313 0.94744 Moxalactam disodium 314 0.95001 Colistimethate sodium 315 0.95138 Sodium ascorbate 316 0.95229 Novobiocin sodium (Albamycin) 317 0.95301 Tolmetin Sodium 318 0.95431 Clindamycin palmitate HCl 319 0.95632 Lovastatin (Mevacor) 320 0.95642 Olanzapine (Zyprexa) 321 0.95710 Ceftiofur hydrochloride 322 0.95869 Clopamide 323 0.96063 Closantel Sodium 324 0.96098 Amorolfine hydrochloride 325 0.96153 Esomeprazole magnesium (Nexium) 326 0.96156 Spectinomycin hydrochloride 327 0.96158 Medroxyprogesterone acetate 328 0.96310 FK-506 (Tacrolimus) 329 0.96315 Arecoline 330 0.96499 Felodipine (Plendil) 331 0.96504 Acetylcysteine 332 0.96596 Medetomidine HCl 333 0.96778 Brompheniramine 334 0.96964 Aceclidine HCl 335 0.97037 Proparacaine HCl 336 0.97050 Bergapten 337 0.97124 Phenoxybenzamine HCl 338 0.97308 Azithromycin dihydrate 339 0.97373 Quipazine maleate 340 0.97386 Benzocaine 341 0.97491 Detomidine HCl 342 0.97494 Chenodeoxycholic acid 343 0.97719 Xylazine HCl 344 0.97729 Itraconazole (Sporanox) 345 0.97769 Bendroflumethiazide 346 0.97778 Bephenium hydroxynaphthoate 347 0.97793 Zoxazolamine 348 0.97832 Terazosin HCl (Hytrin) 349 0.98017 Methapyrilene HCl 350 0.98023 Vitamin B12 351 0.98143 Zaltoprofen 352 0.98247 Xylometazoline HCl 353 0.98259 Enalapril maleate (Vasotec) 354 0.98319 Ibutilide fumarate 355 0.98391 Meloxicam (Mobic) 356 0.98425 Dibenzepine HCl 357 0.98497 Cisplatin 358 0.98718 Tolvaptan (OPC-41061) 359 0.98850 Mitotane (Lysodren) 360 0.98903 Pimecrolimus 361 0.98915 Bicalutamide (Casodex) 362 0.98990 Fosfomycin tromethamine 363 0.99039 Spironolactone 364 0.99206 Pyrilamine maleate 365 0.99331 Milrinone (Primacor) 366 0.99440 Vandetanib (Zactima) 367 0.99497 Famciclovir (Famvir) 368 0.99574 Oxymetazoline hydrochloride 369 0.99595 Entacapone 370 0.99602 Zidovudine (Retrovir) 371 0.99713 Fluocinonide (Vanos) 372 0.99818 Mexiletine HCl 373 0.99859 Methylhydantoin-5-(D) 374 1.00017 Pasiniazid 375 1.00144 Ethionamide 376 1.00291 Tenoxicam (Mobiflex) 377 1.00347 Phenformin hydrochloride 378 1.00378 Pralatrexate (Folotyn) 379 1.00383 Abitrexate (Methotrexate) 380 1.00460 Nateglinide (Starlix) 381 1.00533 Nomifensine maleate 382 1.00579 Mepenzolate bromide 383 1.00685 Clorsulon 384 1.00843 Ribavirin (Copegus) 385 1.00893 Bentiromide 386 1.00900 Ketorolac (Toradol) 387 1.00967 Florfenicol 388 1.01058 Phenytoin (Lepitoin) 389 1.01094 Cyclosporine (Neoral) 390 1.01296 Azithromycin (Zithromax) 391 1.01398 Rifampin (Rifadin, Rimactane) 392 1.01444 Physostigmine salicylate 393 1.01552 Trimethoprim 394 1.01615 Clindamycin 395 1.01648 Propranolol HCl 396 1.01676 Lansoprazole 397 1.01686 Dirithromycin 398 1.01708 Glafenine HCl 399 1.01761 Apatinib (YN968D1) 400 1.01823 Oxprenolol HCl 401 1.02008 Furosemide (Lasix) 402 1.02257 Moroxydine 403 1.02348 Amiloride hydrochloride dihydrate 404 1.02355 Dexmedetomidine HCl (Precedex) 405 1.02355 Isoxicam 406 1.02511 Fosaprepitant dimeglumine 407 1.02599 Betamethasone dipropionate (Diprolene) 408 1.02728 Famprofazone 409 1.02733 Acetylcholine chloride 410 1.02806 Oxybutynin (Ditropan) 411 1.02838 Benzbromarone 412 1.02856 Ropivacaine HCl 413 1.02914 Nevirapine (Viramune) 414 1.02970 Clofibric acid 415 1.03027 Estriol 416 1.03214 Aminocaproic acid (Amicar) 417 1.03250 Fluorometholone acetate 418 1.03252 Pantothenic acid (pantothenate) 419 1.03294 Camylofin chlorhydrate 420 1.03348 Bindarit 421 1.03474 Metolazone (Zaroxolyn) 422 1.03531 Caspofungin acetate 423 1.03556 Amiodarone HCl 424 1.03728 Dabrafenib (GSK2118436) 425 1.03779 Clobetasol propionate 426 1.03825 Febuxostat (Uloric) 427 1.03898 Metaproterenol sulfate 428 1.04002 Lofexidine HCl 429 1.04077 Pancuronium (Pavulon) 430 1.04127 Ceftazidime pentahydrate 431 1.04156 Leflunomide 432 1.04224 Sodium 4-aminohippurate hydrate 433 1.04231 Isradipine (Dynacirc) 434 1.04243 Chlorocresol 435 1.04251 Protionamide (Prothionamide) 436 1.04351 Beclomethasone dipropionate 437 1.04370 Rosiglitazone (Avandia) 438 1.04579 Nadifloxacin 439 1.04618 Azilsartan medoxomil (TAK-491) 440 1.04620 Phenacetin 441 1.04642 Montelukast sodium 442 1.04658 Tropisetron 443 1.04697 Roxatidine acetate HCl 444 1.04735 Phenytoin sodium (Dilantin) 445 1.04786 Secnidazole (Flagentyl) 446 1.04826 Fluocinolone acetonide (Flucort-N) 447 1.05074 Azathioprine (Azasan, Imuran) 448 1.05209 Medrysone 449 1.05225 Zanamivir (Relenza) 450 1.05302 Pindolol 451 1.05321 Nystatin (Mycostatin) 452 1.05488 Piromidic acid 453 1.05533 Calcium gluceptate 454 1.05591 Chromocarb 455 1.05787 Biperiden HCl 456 1.05791 Nefiracetam (Translon) 457 1.05836 Thiamphenicol (Thiophenicol) 458 1.05837 Esomeprazole sodium (Nexium) 459 1.05842 Dexlansoprazole 460 1.05873 Clarithromycin (Biaxin, Klacid) 461 1.05883 Noradrenaline bitartrate monohydrate (Levophed) 462 1.05984 Droperidol 463 1.05997 Roxithromycin (Roxl-150) 464 1.06001 1-Hexadecanol 465 1.06016 Nicotine Ditartrate 466 1.06169 Quetiapine fumarate (Seroquel) 467 1.06406 Bekanamycin 468 1.06449 Tadalafil (Cialis) 469 1.06524 Gallamine triethiodide (Flaxedil) 470 1.06625 Antazoline HCl 471 1.06796 Phenylephrine HCl 472 1.06863 Pyrazinamide (Pyrazinoic acid amide) 473 1.06914 Mercaptopurine 474 1.06922 Carbachol 475 1.06932 Loteprednol etabonate 476 1.06986 Milnacipran HCl 477 1.07019 Mupirocin 478 1.07020 Linagliptin (BI-1356) 479 1.07026 Beta Carotene 480 1.07052 Rosuvastatin calcium (Crestor) 481 1.07149 Ritodrine hydrochloride (Yutopar) 482 1.07339 Cloxacillin sodium (Cloxacap) 483 1.07368 Mometasone furoate 484 1.07381 Primidone (Mysoline) 485 1.07383 Tolazamide 486 1.07462 Ganciclovir 487 1.07496 Halobetasol propionate 488 1.07566 Daidzein 489 1.07574 Entecavir hydrate 490 1.07599 Tripelennamine HCl 491 1.07685 Anisotropine Methylbromide 492 1.07740 Teriflunomide 493 1.07880 Ketoprofen (Actron) 494 1.07896 Betaxolol (Betoptic) 495 1.07905 Dofetilide (Tikosyn) 496 1.08009 Tropicamide 497 1.08014 Nialamide 498 1.08195 Fulvestrant (Faslodex) 499 1.08324 Carbazochrome sodium sulfonate 500 1.08419 Verteporfin (Visudyne) 501 1.08421 Genipin 502 1.08435 Olmesartan medoxomil (Benicar) 503 1.08699 Oxaprozin 504 1.08703 Naphazoline hydrochloride (Naphcon) 505 1.08796 Ornidazole 506 1.08864 Oxeladin Citrate 507 1.08895 Amphotericin B (Abelcet) 508 1.08970 Nifenazone 509 1.09015 L-Thyroxine 510 1.09102 Doxylamine succinate 511 1.09106 Metaraminol bitartrate 512 1.09269 Tioxolone 513 1.09366 Pimozide 514 1.09409 Butacaine 515 1.09481 Ozagrel 516 1.09619 Sulindac (Clinoril) 517 1.09642 PMSF (Phenylmethylsulfonyl fluoride) 518 1.09746 Ponatinib (AP24534) 519 1.09818 Malotilate 520 1.09880 Pazopanib 521 1.10077 Otilonium bromide 522 1.10268 Amoxicillin sodium (Amox) 523 1.10287 Isoprenaline hydrochloride 524 1.10315 Piperacillin sodium 525 1.10322 Nizatidine 526 1.10377 Climbazole 527 1.10390 Methoxamine HCl 528 1.10493 Orphenadrine citrate (Norflex) 529 1.10565 Prednisone (Adasone) 530 1.10581 Procyclidine HCl 531 1.10606 Moguisteine 532 1.10616 Pioglitazone (Actos) 533 1.10681 Cinepazide maleate 534 1.10704 Closantel 535 1.10791 Carbadox 536 1.10830 DAPT (GSI-IX) 537 1.10893 Mevastatin 538 1.11065 Azacyclonol 539 1.11066 Urapidil HCl 540 1.11106 Troxipide 541 1.11192 Gliclazide (Diamicron) 542 1.11255 Avobenzone (Parsol 1789) 543 1.11291 Azilsartan (TAK-536) 544 1.11328 Deflazacort (Calcort) 545 1.11399 Erythromycin (E-Mycin) 546 1.11407 Phenylbutazone (Butazolidin, Butatron) 547 1.11539 Cefdinir (Omnicef) 548 1.11578 Hydrastinine HCl 549 1.11586 Ambrisentan 550 1.11602 Fesoterodine fumarate (Toviaz) 551 1.11655 Rosiglitazone HCl 552 1.11695 Dipyridamole (Persantine) 553 1.11740 Argatroban 554 1.11870 Ropinirole HCl 555 1.11892 2-Thiouracil 556 1.11958 Meclofenamate Sodium 557 1.12040 Sulphadimethoxine 558 1.12070 Nithiamide 559 1.12250 Metoprolol tartrate 560 1.12353 Phenindione (Rectadione) 561 1.12518 Cysteamine HCl 562 1.12609 Dehydroepiandrosterone (DHEA) 563 1.12700 Atovaquone (Atavaquone) 564 1.12770 Aminoglutethimide (Cytadren) 565 1.12785 Zafirlukast (Accolate) 566 1.12863 Rifabutin (Mycobutin) 567 1.12874 Trimebutine 568 1.12875 Haloperidol (Haldol) 569 1.12938 Esmolol HCl 570 1.13185 Disopyramide phosphate 571 1.13249 Acetanilide (Antifebrin) 572 1.13257 Amoxicillin (Amoxycillin) 573 1.13272 Pregnenolone 574 1.13379 Naratriptan HCl 575 1.13433 Diminazene aceturate 576 1.13523 Naloxone HCl 577 1.13568 Moexipril HCl 578 1.13695 Rosiglitazone maleate 579 1.13702 Rivastigmine tartrate (Exelon) 580 1.13740 Carbimazole 581 1.13914 Darunavir ethanolate (Prezista) 582 1.13955 Diclazuril 583 1.13974 Terbinafine (Lamisil, Terbinex) 584 1.14003 Rofecoxib (Vioxx) 585 1.14401 Salicylanilide 586 1.14427 Aripiprazole (Abilify) 587 1.14429 Racecadotril (Acetorphan) 588 1.14501 Edaravone (MCI-186) 589 1.14568 Bromhexine HCl 590 1.14602 Moxonidine 591 1.14620 Vardenafil (Vivanza) 592 1.14694 Deoxycorticosterone acetate 593 1.14718 Metronidazole (Flagyl) 594 1.14733 Dibenzothiophene 595 1.14746 Ozagrel HCl 596 1.14893 Niflumic acid 597 1.14909 Diclofenac 598 1.14909 Hydroxyurea (Cytodrox) 599 1.14940 Cefoperazone (Cefobid) 600 1.15088 Ibuprofen (Advil) 601 1.15156 Amfenac Sodium (monohydrate) 602 1.15315 Sodium salicylate 603 1.15339 Dimaprit 2HCl 604 1.15422 Escitalopram oxalate 605 1.15430 Doxercalciferol (Hectorol) 606 1.15498 Sulfamethoxazole 607 1.15550 Azaperone 608 1.15659 Naproxen (Aleve) 609 1.15689 Hydrocortisone (Cortisol) 610 1.15758 Ammonium glycyrrhizinate (AMGZ) 611 1.15786 Doxifluridine 612 1.15787 Cortisone acetate (Cortone) 613 1.15818 Ractopamine HCl 614 1.15851 Diphemanil methylsulfate 615 1.15870 Enalaprilat dihydrate 616 1.15908 Difloxacin HCl 617 1.15944 Dichlorphenamide (Diclofenamide) 618 1.15980 Potassium iodide 619 1.15992 Cleviprex (Clevidipine) 620 1.16042 Idebenone 621 1.16054 Chlorpropamide 622 1.16088 Dropropizine 623 1.16160 Hydrochlorothiazide 624 1.16169 Triamcinolone (Aristocort) 625 1.16212 Candesartan cilexetil (Atacand) 626 1.16217 Pomalidomide 627 1.16279 Pranoprofen 628 1.16319 Memantine HCl (Namenda) 629 1.16342 Miglitol (Glyset) 630 1.16424 Sulfamethizole (Proklar) 631 1.16447 Olopatadine hydrochloride (Opatanol) 632 1.16449 Betaxolol hydrochloride (Betoptic) 633 1.16458 Omeprazole (Prilosec) 634 1.16486 Pyridoxine hydrochloride 635 1.16511 Pilocarpine HCl 636 1.16545 Vidarabine (Vira-A) 637 1.16618 Alibendol 638 1.16630 Levobetaxolol HCl 639 1.16647 Mecarbinate 640 1.16684 nafcillin sodium monohydrate 641 1.16720 Sparfloxacin 642 1.16749 Mequinol 643 1.16782 Dexrazoxane hydrochloride 644 1.16887 Nalmefene HCl 645 1.17131 Tofacitinib citrate (CP-690550 citrate) 646 1.17133 (+,-)-Octopamine HCl 647 1.17173 Tiratricol 648 1.17232 Valsartan (Diovan) 649 1.17238 Prednisolone (Hydroretrocortine) 650 1.17264 Sulfamethazine 651 1.17342 Methoxsalen (Oxsoralen) 652 1.17448 Famotidine (Pepcid) 653 1.17482 Sulfisoxazole 654 1.17551 Lapatinib 655 1.17554 Penciclovir 656 1.17608 Methscopolamine (Pamine) 657 1.17714 Oxytetracycline dihydrate 658 1.17727 Amprenavir (Agenerase) 659 1.17742 Gabexate mesylate 660 1.18004 Tretinoin (Aberela) 661 1.18028 Pramipexole (Mirapex) 662 1.18029 Mepiroxol 663 1.18138 Retapamulin 664 1.18155 Sulfanilamide 665 1.18163 Levosulpiride (Levogastrol) 666 1.18276 Ethynodiol diacetate 667 1.18359 Voglibose 668 1.18401 Lomustine (CeeNU) 669 1.18421 Azlocillin sodium salt 670 1.18429 Aminophylline (Truphylline) 671 1.18456 Tiopronin (Thiola) 672 1.18501 Cefditoren pivoxil 673 1.18563 Lafutidine 674 1.18587 Ursodiol (Actigal Urso) 675 1.18590 Pipenzolate bromide 676 1.18642 Phosphatidylcholine 677 1.18703 Probucol 678 1.18706 Meptazinol HCl 679 1.18714 Mirtazapine (Remeron, Avanza) 680 1.18741 Lacidipine (Lacipil, Motens) 681 1.18742 Isosorbide 682 1.18774 Doxofylline 683 1.18783 Methenamine (Mandelamine) 684 1.18808 Almotriptan malate (Axert) 685 1.18833 Flutamide (Eulexin) 686 1.18868 Bisoprolol 687 1.18874 Estradiol valerate 688 1.19031 Cilazapril monohydrate (Inhibace) 689 1.19044 Ruxolitinib (INCB018424) 690 1.19084 Rivaroxaban (Xarelto) 691 1.19164 Dimethyl Fumarate 692 1.19173 Oxfendazole 693 1.19212 Enoxacin (Penetrex) 694 1.19219 Bisacodyl 695 1.19278 Nimesulide 696 1.19298 Spiramycin 697 1.19305 Cyromazine 698 1.19389 Sertaconazole nitrate 699 1.19485 Erdosteine 700 1.19498 Genistein 701 1.19504 Methocarbamol (Robaxin) 702 1.19557 Indapamide (Lozol) 703 1.19606 Allopurinol (Zyloprim) 704 1.19628 Suprofen (Profenal) 705 1.19635 Niacin (Nicotinic acid) 706 1.19667 Carprofen 707 1.19681 Sulfamerazine 708 1.19740 Naltrexone HCl 709 1.19752 Capecitabine (Xeloda) 710 1.19805 Pramipexole dihydrochloride monohydrate 711 1.19813 Paeoniflorin 712 1.19820 Irsogladine 713 1.19825 Tolfenamic acid 714 1.19849 Isoniazid (Tubizid) 715 1.19856 Bezafibrate 716 1.19857 Atropine 717 1.19898 Mezlocillin sodium 718 1.20070 Aspartame 719 1.20077 Biotin (Vitamin B7) 720 1.20112 Methimazole (Tapazole, Northyx) 721 1.20125 Bupivacaine hydrochloride (Marcain) 722 1.20243 Prednisolone acetate (Omnipred) 723 1.20300 Dicloxacillin sodium 724 1.20318 Rasagiline mesylate 725 1.20333 Fluconazole 726 1.20391 Methylthiouracil 727 1.20426 Probenecid (Benemid) 728 1.20431 Balofloxacin 729 1.20475 D-Mannitol (Osmitrol) 730 1.20584 Nafamostat mesylate 731 1.20647 Pioglitazone hydrochloride (Actos) 732 1.20660 5-Aminolevulinic acid hydrochloride 733 1.20702 Sulbactam sodium (Unasyn) 734 1.20772 Amiloride hydrochloride (Midamor) 735 1.20796 Clofazimine 736 1.20826 Bifonazole 737 1.20836 Pergolide mesylate 738 1.20882 Methylprednisolone 739 1.20883 Emtricitabine (Emtriva) 740 1.20895 Chlormezanone (Trancopal) 741 1.20897 S-(+)-Rolipram 742 1.21005 Telbivudine (Sebivo, Tyzeka) 743 1.21051 Adrenalone HCl 744 1.21059 Articaine HCl 745 1.21063 Bemegride 746 1.21072 Mepivacaine HCl 747 1.21073 Dexamethasone acetate 748 1.21086 Sulfaguanidine 749 1.21302 Indomethacin (Indocid, Indocin) 750 1.21368 Nicotinamide (Niacinamide) 751 1.21386 Temocapril HCl 752 1.21404 Geniposide 753 1.21413 Ampicillin Trihydrate 754 1.21430 Chlorzoxazone 755 1.21461 Mesna (Uromitexan, Mesnex) 756 1.21478 Carbenoxolone sodium 757 1.21503 Uracil 758 1.21662 Apixaban 759 1.21675 Cilostazol 760 1.21697 Rebamipide 761 1.21779 Meglumine 762 1.21823 Carbamazepine (Carbatrol) 763 1.21952 Vemurafenib (PLX4032) 764 1.22020 Altrenogest 765 1.22062 Betamethasone valerate (Betnovate) 766 1.22073 Pheniramine maleate 767 1.22089 Difluprednate 768 1.22111 Carbenicillin disodium 769 1.22296 Rizatriptan benzoate (Maxalt) 770 1.22309 Fenofibrate (Tricor, Trilipix) 771 1.22335 Estrone 772 1.22415 Chlorothiazide 773 1.22461 Ethamsylate 774 1.22477 Bacitracin 775 1.22485 Uridine 776 1.22536 Rifaximin (Xifaxan) 777 1.22675 Guaifenesin (Guaiphenesin) 778 1.22717 Trichlormethiazide (Achletin) 779 1.22758 Orlistat (Alli, Xenical) 780 1.22793 Natamycin (Pimaricin) 781 1.22809 Raltegravir (MK-0518) 782 1.22860 Acadesine 783 1.22865 Mesalamine (Lialda) 784 1.22902 Betahistine 2HCl 785 1.22967 Levofloxacin (Levaquin) 786 1.23049 toltrazuril 787 1.23068 Amprolium HCl 788 1.23126 Tolbutamide 789 1.23202 Mestranol 790 1.23250 Telaprevir (VX-950) 791 1.23263 Amantadine hydrochloride (Symmetrel) 792 1.23273 Bimatoprost 793 1.23290 Diphenhydramine HCl (Benadryl) 794 1.23419 Valproic acid sodium salt (Sodium valproate) 795 1.23452 Butenafine HCl 796 1.23555 Sulbactam 797 1.23567 DL-Carnitine hydrochloride 798 1.23581 Oxybutynin chloride 799 1.23631 Trometamol 800 1.23679 Diclofenac Potassium 801 1.23761 Betamethasone (Celestone) 802 1.23790 Sulfasalazine (Azulfidine) 803 1.23863 Dydrogesterone 804 1.23897 Triamcinolone acetonide 805 1.24029 Flurbiprofen (Ansaid) 806 1.24095 Acipimox 807 1.24313 Ondansetron hydrochloride (Zofran) 808 1.24314 Tolnaftate 809 1.24372 Betamipron 810 1.24403 Pentoxifylline 811 1.24423 Melatonin 812 1.24442 Xylose 813 1.24468 Ketotifen fumarate (Zaditor) 814 1.24519 Artemether (SM-224) 815 1.24524 Cyclandelate 816 1.24536 Isovaleramide 817 1.24656 Sulfathiazole 818 1.24675 Repaglinide 819 1.24716 Gliquidone 820 1.24744 Oxcarbazepine 821 1.24775 Finasteride 822 1.24784 Sasapyrine 823 1.24816 Ginkgolide A 824 1.24818 Busulfan (Myleran, Busulfex) 825 1.24990 Maraviroc 826 1.25009 Geniposidic acid 827 1.25032 Amfebutamone (Bupropion) 828 1.25038 Tazarotene (Avage) 829 1.25062 Eprosartan mesylate 830 1.25089 Triflusal 831 1.25141 Telmisartan (Micardis) 832 1.25192 Fluticasone propionate (Flonase, Veramyst) 833 1.25195 norethindrone 834 1.25321 Mosapride citrate 835 1.25358 Lithocholic acid 836 1.25382 Candesartan (Atacand) 837 1.25397 Tianeptine sodium 838 1.25409 Sulfameter (Bayrena) 839 1.25497 Piroxicam (Feldene) 840 1.25525 Zolmitriptan (Zomig) 841 1.25550 Pyridostigmine bromide (Mestinon) 842 1.25646 Chloramphenicol (Chloromycetin) 843 1.25720 Diclofenac diethylamine 844 1.25732 Nilotinib (AMN-107) 845 1.25765 Cetirizine dihydrochloride 846 1.25786 Risperidone (Risperdal) 847 1.25804 Streptozotocin (Zanosar) 848 1.25806 Bextra (valdecoxib) 849 1.25987 Thalidomide 850 1.26023 Tranilast (SB 252218) 851 1.26027 Letrozole 852 1.26108 Dextrose (D-glucose) 853 1.26206 Acarbose 854 1.26210 Sorbitol (Glucitol) 855 1.26320 Flumethasone 856 1.26326 Zonisamide 857 1.26366 Penicillin G Sodium 858 1.26444 Lamotrigine 859 1.26560 Propylthiouracil 860 1.26628 Valaciclovir HCl 861 1.26655 Flunixin meglumin 862 1.26678 Linezolid (Zyvox) 863 1.26820 Homatropine methylbromide 864 1.26949 Losartan potassium 865 1.27012 Nepafenac 866 1.27046 Artemisinin 867 1.27055 Methazolastone 868 1.27366 Lidocaine (Alphacaine) 869 1.27480 Guanidine HCl 870 1.27558 Aztreonam (Azactam, Cayston) 871 1.27644 Desonide 872 1.27752 Ethambutol HCl 873 1.27762 Pranlukast 874 1.27909 Meropenem 875 1.28013 Nicorandil (Ikorel) 876 1.28089 Clorprenaline HCL 877 1.28167 Atomoxetine HCl 878 1.28242 Sildenafil citrate 879 1.28278 Aminothiazole 880 1.28312 Adiphenine HCl 881 1.28319 Ramelteon (TAK-375) 882 1.28329 Epalrestat 883 1.28383 Alfuzosin hydrochloride (Uroxatral) 884 1.28405 Glipizide (Glucotrol) 885 1.28416 Pramoxine HCl 886 1.28421 Ramipril (Altace) 887 1.28523 Bumetanide 888 1.28551 Nabumetone 889 1.28570 Trilostane 890 1.28588 Prilocaine 891 1.28641 Acyclovir (Aciclovir) 892 1.28728 Pinacidil 893 1.28776 Levetiracetam 894 1.28793 Dyphylline (Dilor) 895 1.28847 Zileuton 896 1.28905 Ranolazine dihydrochloride 897 1.29021 TAME 898 1.29034 Flucytosine (Ancobon) 899 1.29199 Pidotimod 900 1.29288 Tetracaine hydrochloride (Pontocaine) 901 1.29450 Cytidine 902 1.29553 Flumequine 903 1.29680 Gemfibrozil (Lopid) 904 1.30065 Cinchophen 905 1.30260 Praziquantel (Biltricide) 906 1.30307 Pefloxacin mesylate 907 1.30645 Voriconazole 908 1.30942 Diethylstilbestrol (Stilbestrol) 909 1.31264 Bepotastine besilate 910 1.31288 Bethanechol chloride 911 1.31296 Adenosine (Adenocard) 912 1.31340 Felbamate 913 1.31518 Benazepril hydrochloride 914 1.31740 valganciclovir hydrochloride 915 1.31745 tinidazole 916 1.31816 Homatropine bromide 917 1.31944 Glyburide (Diabeta) 918 1.32051 Vitamin C (Ascorbic acid) 919 1.32147 Dienogest 920 1.32181 Moclobemide 921 1.32292 Diltiazem HCl (Tiazac) 922 1.32488 Clopidogrel (Plavix) 923 1.32551 Flumazenil 924 1.32664 Rolipram 925 1.32690 Bexarotene 926 1.32714 Phenothrin 927 1.32836 Alfacalcidol 928 1.32961 Dacarbazine (DTIC-Dome) 929 1.33076 Amidopyrine 930 1.33080 Dutasteride 931 1.33182 Vecuronium bromide 932 1.33327 Ampicillin sodium 933 1.33457 Zalcitabine 934 1.33510 Doxapram HCl 935 1.33754 Gimeracil 936 1.33768 Etomidate 937 1.33806 Glimepiride 938 1.33838 Aspirin (Acetylsalicylic acid) 939 1.33889 Nalidixic acid (NegGram) 940 1.33962 Anagrelide HCl 941 1.33990 Lenalidomide 942 1.34150 Cyclamic acid 943 1.34272 Clindamycin hydrochloride (Dalacin) 944 1.34309 Lornoxicam (Xefo) 945 1.34355 Levonorgestrel (Levonelle) 946 1.34396 Ampiroxicam 947 1.34597 Didanosine (Videx) 948 1.34666 Benzoic acid 949 1.34673 Fenspiride HCl 950 1.34758 Stavudine 951 1.34765 Rocuronium bromide 952 1.34772 Ifosfamide 953 1.34784 Procaine (Novocaine) HCl 954 1.34908 Antipyrine 955 1.34919 Venlafaxine 956 1.35119 Vitamin D3 (Cholecalciferol) 957 1.35252 Sumatriptan succinate 958 1.35367 Choline Chloride 959 1.35487 Sodium Nitroprusside 960 1.35584 tetrahydrozoline hydrochloride 961 1.35635 Divalproex sodium 962 1.35694 Sodium Picosulfate 963 1.35698 Allylthiourea 964 1.35737 Nelarabine (Arranon) 965 1.35782 Drospirenone 966 1.35785 Cimetidine (Tagamet) 967 1.35817 Phthalylsulfacetamide 968 1.35955 Cephalexin (Cefalexin) 969 1.36371 Vitamin D2 970 1.36388 Clonidine hydrochloride (Catapres) 971 1.36629 MDV3100 (Enzalutamide) 972 1.36697 Aniracetam 973 1.36711 Captopril (Capoten) 974 1.37001 Moxifloxacin hydrochloride 975 1.37010 Tylosin tartrate 976 1.37075 Tizanidine HCl 977 1.37123 Betapar (Meprednisone) 978 1.37196 Calcifediol 979 1.37592 Isotretinoin 980 1.37853 Brinzolamide 981 1.38013 Calcitriol (Rocaltrol) 982 1.38024 Decamethonium bromide 983 1.38056 Rufinamide (Banzel) 984 1.38104 Etodolac (Lodine) 985 1.38265 Anastrozole 986 1.38459 Posaconazole 987 1.38473 Doripenem hydrate 988 1.38684 Suplatast tosylate 989 1.38774 Ftorafur 990 1.38933 Megestrol acetate 991 1.38943 Prasugrel (Effient) 992 1.38972 Methyclothiazide 993 1.39341 Dexamethasone 994 1.39502 Avanafil 995 1.40306 Amisulpride 996 1.40325 Aclidinium bromide 997 1.40466 Cyclophosphamide monohydrate 998 1.41631 Topiramate 999 1.41905 Hyoscyamine (Daturine) 1,000 1.41969 olsalazine sodium 1,001 1.42237 Adenine hydrochloride 1,002 1.42753 sulfacetamide sodium 1,003 1.43073 Adapalene 1,004 1.43160 Gestodene 1,005 1.43216 Ronidazole 1,006 1.44236 Mefenamic acid 1,007 1.44284 Fexofenadine HCl 1,008 1.44948 Cinoxacin 1,009 1.45237 Erythromycin ethylsuccinate 1,010 1.45462 Roflumilast (Daxas) 1,011 1.45805 Mirabegron (YM178) 1,012 1.45874 Sodium nitrite 1,013 1.49032 Aminosalicylate sodium 1,014 1.49986 Agomelatine 1,015 1.51786 Acebutolol HCl 1,016 1.51910 Acitretin 1,017 1.55862 Flavoxate HCl 1,018 1.56718 Altretamine (Hexalen)