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Method for the Detection of Zeranol and SOP : ARO/442 Taleranol In
TITLE: Method for the detection of zeranol and S.O.P. : ARO/442 taleranol in meat and liver Page : 1 of 9 . Revision : 0 Date : 990715 1. INTRODUCTION 1.1 Summary This SOP describes a screening and confirmation method for the determination of resorcyclic acid lactones (RAL’s) in meat and liver samples of bovine origin. A procedure is described for the detection of a-zearalanol (zeranol) and b-zearalanol (taleranol) by a combination of solid phase extraction (SPE) and GC-MS. The method consist of, digestion of the meat sample using the enzyme protease and hydrolysis of the liver sample using suc d’Helix Pomatia, extraction of the RAL’s with tert-butylmethylether (TBME), purification using reversed-phase C18 cartridges. This method can also be used for the metabolites a-zearalenol, b-zearalenol, zearalanone and zearalenone. When doing so validation for these compounds is necessary. 1.2 Field of application The method is used to perform routine screening in meat and liver samples and has proven to be suitable for the analysis of a-zearalanol and b-zearalanol. The limit of detection is 0.5 mg/g based on the detection of the most abundant diagnostic ions namely m/z 433 and m/z 437 for the internal standard, with a response at the correct retention time exceeding the signal to noise ratio of 3. The method is validated according to SOP ARO/425 (1.3.3). 1.3 References 1.3.1. H.J. van Rossum et al, Multi residue analysis anabolic agents, SOP ARO/113, revision 4, 21 January 1997, RIVM. -
Étude in Vivo / in Vitro De L'effet De La Zéaralénone Sur L'expression De
Étude in vivo / in vitro de l’effet de la zéaralénone sur l’expression de transporteurs ABC majeurs lors d’une exposition gestationnelle ou néonatale Farah Koraichi To cite this version: Farah Koraichi. Étude in vivo / in vitro de l’effet de la zéaralénone sur l’expression de transporteurs ABC majeurs lors d’une exposition gestationnelle ou néonatale. Toxicologie. Université Claude Bernard - Lyon I, 2012. Français. NNT : 2012LYO10314. tel-01071280 HAL Id: tel-01071280 https://tel.archives-ouvertes.fr/tel-01071280 Submitted on 3 Oct 2014 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. N° d’ordre 314-2012 Année 2012 THESE DE L’UNIVERSITE DE LYON Délivrée par L’UNIVERSITE CLAUDE BERNARD LYON 1 ECOLE DOCTORALE INTERDISCIPLINAIRE SCIENCES-SANTE (EDISS) DIPLOME DE DOCTORAT (arrêté du 7 août 2006) soutenue publiquement le 20 décembre 2012 par Mlle Farah KORAÏCHI TITRE : ETUDE IN VIVO/IN VITRO DE L’EFFET DE LA ZEARALENONE SUR l’EXPRESSION DE TRANSPORTEURS ABC MAJEURS LORS D’UNE EXPOSITION GESTATIONNELLE OU NEONATALE Directeur de thèse: Sylvaine LECOEUR Co-directeur -
Annex D to the Report of the Panel to Be Found in Document WT/DS320/R
WORLD TRADE WT/DS320/R/Add.4 31 March 2008 ORGANIZATION (08-0902) Original: English UNITED STATES – CONTINUED SUSPENSION OF OBLIGATIONS IN THE EC – HORMONES DISPUTE Report of the Panel Addendum This addendum contains Annex D to the Report of the Panel to be found in document WT/DS320/R. The other annexes can be found in the following addenda: – Annex A: Add.1 – Annex B: Add.2 – Annex C: Add.3 – Annex E: Add.5 – Annex F: Add.6 – Annex G: Add.7 WT/DS320/R/Add.4 Page D-1 ANNEX D REPLIES OF THE SCIENTIFIC EXPERTS TO QUESTIONS POSED BY THE PANEL A. GENERAL DEFINITIONS 1. Please provide brief and basic definitions for the six hormones at issue (oestradiol-17β, progesterone, testosterone, trenbolone acetate, zeranol, and melengestrol acetate), indicating the source of the definition where applicable. Dr. Boisseau 1. Oestradiol-17β is the most active of the oestrogens hormone produced mainly by the developing follicle of the ovary in adult mammalian females but also by the adrenals and the testis. This 18-carbon steroid hormone is mainly administered as such or as benzoate ester alone (24 or 45 mg for cattle) or in combination (20 mg) with testosterone propionate (200 mg for heifers), progesterone (200 mg for heifers and steers) and trenbolone (200 mg and 40 mg oestradiol-17β for steers) by a subcutaneous implant to the base of the ear to improve body weight and feed conversion in cattle. The ear is discarded at slaughter. 2. Progesterone is a hormone produced primarily by the corpus luteum in the ovary of adult mammalian females. -
ACE Food Beverage Applications Guide
Food and Beverage Applications Guide Ultra-Inert Base Deactivated UHPLC / HPLC Columns Contents Application Index 1 Analyte Index 2 - 4 Application Notes 5 - 90 Send us your application and receive a free ACE column Send us your application on an ACE column and help extend our applications database. Your proven method will enable your chromatography colleagues to benefit and if we select your application for publication we’ll send you a FREE ACE analytical column of your choice. To submit your application e-mail us at: [email protected] ACE ® Food and Beverage Applications: Application Index Application Pages Application Pages Additives and intense sweeteners 5 Organic acids 2 47 Argicultural pesticides 6 Organic acids 3 48 Amino acids in peas 7 Organic acids 4 49 Amino acids and biogenic amines in wine and beer 8 Organophosphorus flame retardants in water by LC-MS/MS 50 Aminoglycosides in eggs 9 Organophosphorus isomer flame retardants in water 51 Annatto 10 Paraben preservatives 52 Anthocyanins from sambucus nigra (elderberry) 11 Perfluoro acids by LC-MS/MS 53 Appetite suppressants by LC-MS 12 Perfluoroalkyl substances by ion pairing LC-MS/MS 54 Arsenolipids from edible seaweed 13 Perfluorinated compounds in water by LC-MS/MS 55 Artificial colours (water soluble) 14 Pesticides (250 analytes) by LC-MS/MS 56 Artificial food colouring 15 Pesticides (47 analytes) by LC-MS/MS 60 Artificial sweeteners global method 16 Pesticides in water 61 Artificial sweeteners (stevia glycosides) 17 Phenolic compounds in ground water and landfill leachates -
Compound CAS
https://www.fermentek.com inhoud: Compound CAS# 100ìg 15 Acetoxyscirpenol 2623-22-5 1 mg 15-Acetyl-DON 88337-96-6 5mg 17-AAG 75747-14-7 10mg 17-DMAG 467214-20-6 25mg 3-Acetyl-DON 50722-38-8 50mg 7-Amino-Actinomycin D 7240-37-1 100mg A23187 Ca-Mg 52665-69-7 250mg A23187, 4-Bromo 76455-48-6 500mg A23187, free acid 52665-69-7 1gr Actinomycin D (≥ 97%) 50-76-0 5gr Actinomycin D (≥ 99%) 50-76-0 Aflatoxicol 29611-03-8 Aflatoxin B1 1162-65-8 Aflatoxin B2 7220-81-7 Aflatoxin G1 1165-39-5 Aflatoxin G2 7241-98-7 Aflatoxin M1 6795-23-9 Aflatoxin M2 6885-57-0 Alamethicin 27061-78-5 Alpha Zearalanol 26538-44-3 Alpha Zearalenol 36455-72-8 Altenuene 889101-41-1 Alternariol 641-38-3 Alternariol monomethyl Ether 26894-49-5 Altertoxin l 56258-32-3 Anisomycin 22862-76-6 Ansamitocin P3 66584-72-3 Antimycin A 1397-94-0 Aphidicolin 38966-21-1 Apicidin 183506-66-3 Ascomycin 11011-38-4 Aureothricin 574-95-8 Bafilomycin A1 88899-55-2 Bafilomycin B1 88899-56-3 Beauvericin 26048-05-5 Beta Zearalanol 42422-68-4 Beta Zearalenol 71030-11-0 Blasticidin S.HCl 9-3-3513 Borrelidin 7184-60-3 Brefeldin A 20350-15-6 Castanospermine 79831-76-8 Celastrol (tripterine) 34157-83-0 Cercosporin 35082-49-6 Cerulenin 17397-89-6 Chaetocin 28097-03-2 Chaetoglobosin A 50335-03-0 Chelerythrine Cl 3895-92-9 Chromomycin A3 7059-24-7 Citreoviridin 25425-12-1 Citrinin 518-75-2 Concanamycin A 80890-47-7 Cordycepin 73-03-3 Curvularin 10140-70-2 Cyclopamine 4449-51-8 Cyclopiazonic Acid 18172-33-3 Cytochalasin E 36011-19-5 Cytochalasin A 14110-64-6 Cytochalasin B 14930-96-2 Cytochalasin C 22144-76-9 -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9 -
TGA Review of Hgps
A REVIEW TO UPDATE AUSTRALIA’S POSITION ON THE HUMAN SAFETY OF RESIDUES OF HORMONE GROWTH PROMOTANTS (HGPs) USED IN CATTLE Prepared by Chemical Review and International Harmonisation Section Office of Chemical Safety Therapeutic Goods Administration of the Department of Health and Ageing Canberra July 2003 A draft of this report was tabled at the 25th Meeting of the Advisory Committee on Pesticides and Health (ACPH), held in Canberra on the 1st May 2003. The report was subsequently endorsed out-of-session by the ACPH. Hormone Growth Promotants TABLE OF CONTENTS ABBREVIATIONS ................................................................................................................................................................4 EXECUTIVE SUMMARY ..................................................................................................................................................7 INTRODUCTION..................................................................................................................................................................9 HEALTH CONCERNS ASSOCIATED WITH HGP S................................................................................................................9 DIFFICULTIES ASSOCIAT ED WITH ASSESSING THE SAFETY OF HGPS.........................................................................10 RISK ASSESSMENTS OF HGP S .........................................................................................................................................10 PURPOSE OF THE CURRENT -
NORMATIVE INSTRUCTION 5 of APRIL 23, 2019 (Published in the Official Gazette of the Federal Government (DOU) on 25/04/2019)
NORMATIVE INSTRUCTION 5 OF APRIL 23, 2019 (Published in the Official Gazette of the Federal Government (DOU) on 25/04/2019) THE SECRETARY FOR ANIMAL AND PLANT HEALTH OF THE MINISTRY OF AGRICULTURE, LIVESTOCK AND FOOD SUPPLY, using the power attributed to him by Articles 21 and 63, of Appendix I, of Decree 9,667, of January 2, 2019, taking into consideration what is set forth in Ordinance (Portaria) 51, of February 6, 1986, Ordinance (Portaria) 527 of August 15, 1995, SDA Normative Instruction 42 of December 20, 1999, Decree 9,013 of March 29, 2017; and what is set forth in Case File 21000.022222/2019-71, resolves: Article 1. To approve the publication of the sampling plan and the reference limits for the National Plan for the Control of Residues and Contaminants in Animal Products - PNCRC of 2019, for the chains of beef, pork, goat, mutton, equine, rabbit, poultry, ostrich meat, and milk, fisheries, honey and eggs. Paragraph 1. The sampling plan and limits of reference stated in the heading hereof will be published in the Ministry of Agriculture, Livestock and Food Supply. Article 2. The tests for the Monitoring and Exploratory Subprogram of the PNCRC described in Article 1 herein are be performed in the official and authorized laboratories of the National Network of Agricultural Laboratories of the Unified System for Animal and Plant Health, as established by Normative Instruction 57 of December 11, 2013. Article. 3 This Normative Instruction shall come into force as of the date of its publication. JOSÉ GUILHERME TOLLSTADIUS LEAL TABLE -
World Mycotoxin Journal, February 2014; 7 (1): 3-33 Publishers
Wageningen Academic World Mycotoxin Journal, February 2014; 7 (1): 3-33 Publishers Developments in mycotoxin analysis: an update for 2012-2013 F. Berthiller1, P.A. Burdaspal2, C. Crews3, M.H. Iha4, R. Krska1, V.M.T. Lattanzio5, S. MacDonald3, R.J. Malone6, C. Maragos7, M. Solfrizzo5, J. Stroka8 and T.B. Whitaker9 1University of Natural Resources and Life Sciences, Vienna, Department for Agrobiotechnology (IFA-Tulln), Christian Doppler Laboratory for Mycotoxin Metabolism and Center for Analytical Chemistry, Konrad Lorenz Str. 20, 3430 Tulln, Austria; 2National Centre for Food, Spanish Food Safety and Nutrition Agency, Carretera de Majadahonda a Pozuelo km 5, 228220 Majadahonda, Spain; 3The Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, United Kingdom; 4Instituto Adolfo Lutz, Laboratrio I de Ribeiro Preto, Av Dr Arnaldo 355, CEP 14085-410, Ribeiro Preto SP, Brazil; 5Institute of Sciences of Food Production, National Research Council, Via Amendola 122/o, Bari 700126, Italy; 6Trilogy Analytical Laboratory, 870 Vossbrink Drive, Washington, MO 63090, USA; 7USDA, ARS National Center for Agricultural Utilization Research, 1815 N. University St., Peoria, IL 61604, USA; 8Institute for Reference Materials and Measurements (IRMM), European Commission Joint Research Centre, Retieseweg 111, 2440 Geel, Belgium; 9Biological and Agricultural Engineering Department, N.C. State University, P.O. Box 7625, Raleigh, NC 27695-7625, USA; [email protected] Received: 12 September 2013 / Accepted: 2 December 2013 © 2014 Wageningen Academic Publishers REVIEW ARTICLE Abstract This review highlights developments in mycotoxin analysis and sampling over a period between mid-2012 and mid-2013. It covers the major mycotoxins: aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone. -
WT/DS320/R Page 141
WT/DS320/R Page 141 (b) Summary of the main arguments of the parties315 7.2 With reference to the Panel's question whether panels are permitted to open hearings to public observation under Articles 12 (including Appendix 3), 14.1 and 17.10 of the DSU, the European Communities argues that a panel may adopt working procedures that foresee open hearings, as Article 12.1 of the DSU provides that panels may depart from the working procedures in Appendix 3 after consulting the parties to the dispute. 7.3 The European Communities also argues that this conclusion is not affected by Article 14.1 of the DSU on confidentiality of panel deliberations. The term "deliberations" does not cover the meetings with the parties, for which a different terminology is used in Appendix 3 of the DSU. 7.4 The European Communities considers that in the present case where all the parties have agreed to open hearings, the Panel should accommodate the parties' request. Article 18.2 of the DSU also supports the position that parties are entitled to "waive" the confidentiality of their positions. 7.5 Regarding the legal implications of open hearings on covered persons under the Rules of Conduct, the European Communities considers that no legal issues arise under the Rules of Conduct. In the European Communities view, the Rules of Conduct are and remain fully binding on all covered persons in this dispute, even if the hearings are opened to the public. The Panel's deliberations will in any event not be affected by the opening and remain confidential, as required by Article 14.1 of the DSU. -
Wo 2008/127291 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 23 October 2008 (23.10.2008) WO 2008/127291 A2 (51) International Patent Classification: Jeffrey, J. [US/US]; 106 Glenview Drive, Los Alamos, GOlN 33/53 (2006.01) GOlN 33/68 (2006.01) NM 87544 (US). HARRIS, Michael, N. [US/US]; 295 GOlN 21/76 (2006.01) GOlN 23/223 (2006.01) Kilby Avenue, Los Alamos, NM 87544 (US). BURRELL, Anthony, K. [NZ/US]; 2431 Canyon Glen, Los Alamos, (21) International Application Number: NM 87544 (US). PCT/US2007/021888 (74) Agents: COTTRELL, Bruce, H. et al.; Los Alamos (22) International Filing Date: 10 October 2007 (10.10.2007) National Laboratory, LGTP, MS A187, Los Alamos, NM 87545 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY,BZ, CA, CH, (30) Priority Data: CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, 60/850,594 10 October 2006 (10.10.2006) US ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, (71) Applicants (for all designated States except US): LOS LR, LS, LT, LU, LY,MA, MD, ME, MG, MK, MN, MW, ALAMOS NATIONAL SECURITY,LLC [US/US]; Los MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, Alamos National Laboratory, Lc/ip, Ms A187, Los Alamos, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, NM 87545 (US). -
Front Page Food
Food Safety www.chiron.no Chiron AS Stiklestadveien 1 N-7041 Trondheim, Norway Tel: +47 73 87 44 90 Fax: +47 73 87 44 99 Mail: [email protected] www.chiron.no Food Safety Catalogue - 2012 Table of contents General ......................................................................................................................................................... 2 Food safety I: Highly Purified Natural Toxins for Food Analysis ............................................................. 4 Food Safety II: Food Contaminants ............................................................................................................. 9 Food safety III: Food Colour and Aroma .................................................................................................... 15 Isopropylthioxanthone (ITX) ...................................................................................................................... 19 Desphenylchloridazon-15N2........................................................................................................................20 PCBs .......................................................................................................................................................... 21 PBDEs, PBBs, Flame Retardants, Halobenzenes and Phenols ................................................................... 27 PCNs, PBNs and HaloPAHs ....................................................................................................................... 35 SCCP/PCA, Chloroalkanes .......................................................................................................................