Compound CAS
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Method for the Detection of Zeranol and SOP : ARO/442 Taleranol In
TITLE: Method for the detection of zeranol and S.O.P. : ARO/442 taleranol in meat and liver Page : 1 of 9 . Revision : 0 Date : 990715 1. INTRODUCTION 1.1 Summary This SOP describes a screening and confirmation method for the determination of resorcyclic acid lactones (RAL’s) in meat and liver samples of bovine origin. A procedure is described for the detection of a-zearalanol (zeranol) and b-zearalanol (taleranol) by a combination of solid phase extraction (SPE) and GC-MS. The method consist of, digestion of the meat sample using the enzyme protease and hydrolysis of the liver sample using suc d’Helix Pomatia, extraction of the RAL’s with tert-butylmethylether (TBME), purification using reversed-phase C18 cartridges. This method can also be used for the metabolites a-zearalenol, b-zearalenol, zearalanone and zearalenone. When doing so validation for these compounds is necessary. 1.2 Field of application The method is used to perform routine screening in meat and liver samples and has proven to be suitable for the analysis of a-zearalanol and b-zearalanol. The limit of detection is 0.5 mg/g based on the detection of the most abundant diagnostic ions namely m/z 433 and m/z 437 for the internal standard, with a response at the correct retention time exceeding the signal to noise ratio of 3. The method is validated according to SOP ARO/425 (1.3.3). 1.3 References 1.3.1. H.J. van Rossum et al, Multi residue analysis anabolic agents, SOP ARO/113, revision 4, 21 January 1997, RIVM. -
Étude in Vivo / in Vitro De L'effet De La Zéaralénone Sur L'expression De
Étude in vivo / in vitro de l’effet de la zéaralénone sur l’expression de transporteurs ABC majeurs lors d’une exposition gestationnelle ou néonatale Farah Koraichi To cite this version: Farah Koraichi. Étude in vivo / in vitro de l’effet de la zéaralénone sur l’expression de transporteurs ABC majeurs lors d’une exposition gestationnelle ou néonatale. Toxicologie. Université Claude Bernard - Lyon I, 2012. Français. NNT : 2012LYO10314. tel-01071280 HAL Id: tel-01071280 https://tel.archives-ouvertes.fr/tel-01071280 Submitted on 3 Oct 2014 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. N° d’ordre 314-2012 Année 2012 THESE DE L’UNIVERSITE DE LYON Délivrée par L’UNIVERSITE CLAUDE BERNARD LYON 1 ECOLE DOCTORALE INTERDISCIPLINAIRE SCIENCES-SANTE (EDISS) DIPLOME DE DOCTORAT (arrêté du 7 août 2006) soutenue publiquement le 20 décembre 2012 par Mlle Farah KORAÏCHI TITRE : ETUDE IN VIVO/IN VITRO DE L’EFFET DE LA ZEARALENONE SUR l’EXPRESSION DE TRANSPORTEURS ABC MAJEURS LORS D’UNE EXPOSITION GESTATIONNELLE OU NEONATALE Directeur de thèse: Sylvaine LECOEUR Co-directeur -
Annex D to the Report of the Panel to Be Found in Document WT/DS320/R
WORLD TRADE WT/DS320/R/Add.4 31 March 2008 ORGANIZATION (08-0902) Original: English UNITED STATES – CONTINUED SUSPENSION OF OBLIGATIONS IN THE EC – HORMONES DISPUTE Report of the Panel Addendum This addendum contains Annex D to the Report of the Panel to be found in document WT/DS320/R. The other annexes can be found in the following addenda: – Annex A: Add.1 – Annex B: Add.2 – Annex C: Add.3 – Annex E: Add.5 – Annex F: Add.6 – Annex G: Add.7 WT/DS320/R/Add.4 Page D-1 ANNEX D REPLIES OF THE SCIENTIFIC EXPERTS TO QUESTIONS POSED BY THE PANEL A. GENERAL DEFINITIONS 1. Please provide brief and basic definitions for the six hormones at issue (oestradiol-17β, progesterone, testosterone, trenbolone acetate, zeranol, and melengestrol acetate), indicating the source of the definition where applicable. Dr. Boisseau 1. Oestradiol-17β is the most active of the oestrogens hormone produced mainly by the developing follicle of the ovary in adult mammalian females but also by the adrenals and the testis. This 18-carbon steroid hormone is mainly administered as such or as benzoate ester alone (24 or 45 mg for cattle) or in combination (20 mg) with testosterone propionate (200 mg for heifers), progesterone (200 mg for heifers and steers) and trenbolone (200 mg and 40 mg oestradiol-17β for steers) by a subcutaneous implant to the base of the ear to improve body weight and feed conversion in cattle. The ear is discarded at slaughter. 2. Progesterone is a hormone produced primarily by the corpus luteum in the ovary of adult mammalian females. -
ACE Food Beverage Applications Guide
Food and Beverage Applications Guide Ultra-Inert Base Deactivated UHPLC / HPLC Columns Contents Application Index 1 Analyte Index 2 - 4 Application Notes 5 - 90 Send us your application and receive a free ACE column Send us your application on an ACE column and help extend our applications database. Your proven method will enable your chromatography colleagues to benefit and if we select your application for publication we’ll send you a FREE ACE analytical column of your choice. To submit your application e-mail us at: [email protected] ACE ® Food and Beverage Applications: Application Index Application Pages Application Pages Additives and intense sweeteners 5 Organic acids 2 47 Argicultural pesticides 6 Organic acids 3 48 Amino acids in peas 7 Organic acids 4 49 Amino acids and biogenic amines in wine and beer 8 Organophosphorus flame retardants in water by LC-MS/MS 50 Aminoglycosides in eggs 9 Organophosphorus isomer flame retardants in water 51 Annatto 10 Paraben preservatives 52 Anthocyanins from sambucus nigra (elderberry) 11 Perfluoro acids by LC-MS/MS 53 Appetite suppressants by LC-MS 12 Perfluoroalkyl substances by ion pairing LC-MS/MS 54 Arsenolipids from edible seaweed 13 Perfluorinated compounds in water by LC-MS/MS 55 Artificial colours (water soluble) 14 Pesticides (250 analytes) by LC-MS/MS 56 Artificial food colouring 15 Pesticides (47 analytes) by LC-MS/MS 60 Artificial sweeteners global method 16 Pesticides in water 61 Artificial sweeteners (stevia glycosides) 17 Phenolic compounds in ground water and landfill leachates -
Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam As CYP3A Probe Drug in a Porcine Animal Model: a Pilot Study
fphar-10-00399 April 14, 2019 Time: 11:9 # 1 View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Ghent University Academic Bibliography ORIGINAL RESEARCH published: 16 April 2019 doi: 10.3389/fphar.2019.00399 Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam as CYP3A Probe Drug in a Porcine Animal Model: A Pilot Study Wim Schelstraete*, Mathias Devreese and Siska Croubels* Laboratory of Pharmacology and Toxicology, Department of Pharmacology, Toxicology and Biochemistry, Faculty Edited by: of Veterinary Medicine, Ghent University, Ghent, Belgium Yiqun Deng, South China Agricultural University, China Cytochrome P450 enzymes (CYP) are important catalyzing proteins involved in Reviewed by: the biotransformation of endogenous and xenobiotic compounds. However, their Takuya Miyawaki, expression and/or activity can be altered by exposure to contaminants such Okayama University, Japan Shingen Misaka, as mycotoxins. In vitro incubations in porcine hepatic microsomes revealed a Fukushima Medical University, Japan potent inhibition of the midazolam (CYP3A) biotransformation by T-2 toxin (T-2) Barbora Szotáková, Charles University, Czechia (Ki = 27.0 ± 3.97 mM) and zearalenone (ZEA) (Ki = 1.1 ± 0.22 mM). Consequently, *Correspondence: the in vivo impact of 2 weeks exposure to T-2 (1,000 mg/kg feed) or ZEA (500 mg/kg Wim Schelstraete feed) on the pharmacokinetics (PK) of midazolam (MDZ) as a CYP3A probe drug was [email protected] investigated in pigs, and was compared to a control group receiving no mycotoxins. Siska Croubels [email protected] MDZ was chosen as this drug undergoes substantial first-pass metabolism in humans with equal contribution of the intestine and liver. -
03-Speranda.Vp:Corelventura
Acta Veterinaria (Beograd), Vol. 56, No. 2-3, 121-136, 2006. DOI: 10.2298/AVB0603121S UDK 619:636.4.087.7 HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS OF WEANED PIGLETS FED ON FODDER MIXTURE CONTAMINATED BY ZEARALENONE WITH ADDITION OF CLINOPTILOLITE [PERANDA MARCELA*, LIKER B**, [PERANDA T*, [ERI] V***, ANTUNOVI] Z*, GRABAREVI] @****, SEN^I] \*, GRGURI] D***** and STEINER Z* *Faculty of Agriculture, Osijek, Croatia; **Faculty of Agriculture, Zagreb, Croatia; ***Clinical Hospital Osijek, Croatia; ****Faculty of Veterinary Medicine, Zagreb, Croatia; *****Centar for Livestock Improvement, Osijek (Received 20. October 2005) The effect of zeolite clinoptilolite (CLIN) on some metabolic parameters in blood serum and haematological values in weaned piglets fed with increased levels of zearalenone (ZEN) was investigated over a 14-day period. The research involved four groups of weaned piglets aged 40 to 54 days. All groups were fed on fodder mixture for growing pigs containing 20% crude protein and 12.57 MJ ME/kg. The first control group (C1) received a concentrate mixture without added ZEN or mycotoxin adsorbent Min-a-Zel Plus®. The second control group (C2) was fed on fodder mixture containing 0.2% of modified clinoptilolite (Min-a-Zel Plus®; levels of zearalenone <5.1 ng/g). Piglets in the experimental group (E1) were fed on fodder mixture containing added zeralenone (3 mg/kg) (Sigma-Aldrich Co) and 0.2% of Min-a-Zel Plus® preparation. The second experimental group (E2) was fed on fodder mixture to which 3 mg/kg of zearalenone was added, but with no addition of Min-a-Zel Plus®. Oestrogenic effect of ZEN was evident in the sinergistic action with insulin which was manifested in an increased total protein level, lower level of glucose, triacylglycerols, serum iron, a higer level of cholesterol and higher aminotransaminase activity. -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9 -
TGA Review of Hgps
A REVIEW TO UPDATE AUSTRALIA’S POSITION ON THE HUMAN SAFETY OF RESIDUES OF HORMONE GROWTH PROMOTANTS (HGPs) USED IN CATTLE Prepared by Chemical Review and International Harmonisation Section Office of Chemical Safety Therapeutic Goods Administration of the Department of Health and Ageing Canberra July 2003 A draft of this report was tabled at the 25th Meeting of the Advisory Committee on Pesticides and Health (ACPH), held in Canberra on the 1st May 2003. The report was subsequently endorsed out-of-session by the ACPH. Hormone Growth Promotants TABLE OF CONTENTS ABBREVIATIONS ................................................................................................................................................................4 EXECUTIVE SUMMARY ..................................................................................................................................................7 INTRODUCTION..................................................................................................................................................................9 HEALTH CONCERNS ASSOCIATED WITH HGP S................................................................................................................9 DIFFICULTIES ASSOCIAT ED WITH ASSESSING THE SAFETY OF HGPS.........................................................................10 RISK ASSESSMENTS OF HGP S .........................................................................................................................................10 PURPOSE OF THE CURRENT -
NORMATIVE INSTRUCTION 5 of APRIL 23, 2019 (Published in the Official Gazette of the Federal Government (DOU) on 25/04/2019)
NORMATIVE INSTRUCTION 5 OF APRIL 23, 2019 (Published in the Official Gazette of the Federal Government (DOU) on 25/04/2019) THE SECRETARY FOR ANIMAL AND PLANT HEALTH OF THE MINISTRY OF AGRICULTURE, LIVESTOCK AND FOOD SUPPLY, using the power attributed to him by Articles 21 and 63, of Appendix I, of Decree 9,667, of January 2, 2019, taking into consideration what is set forth in Ordinance (Portaria) 51, of February 6, 1986, Ordinance (Portaria) 527 of August 15, 1995, SDA Normative Instruction 42 of December 20, 1999, Decree 9,013 of March 29, 2017; and what is set forth in Case File 21000.022222/2019-71, resolves: Article 1. To approve the publication of the sampling plan and the reference limits for the National Plan for the Control of Residues and Contaminants in Animal Products - PNCRC of 2019, for the chains of beef, pork, goat, mutton, equine, rabbit, poultry, ostrich meat, and milk, fisheries, honey and eggs. Paragraph 1. The sampling plan and limits of reference stated in the heading hereof will be published in the Ministry of Agriculture, Livestock and Food Supply. Article 2. The tests for the Monitoring and Exploratory Subprogram of the PNCRC described in Article 1 herein are be performed in the official and authorized laboratories of the National Network of Agricultural Laboratories of the Unified System for Animal and Plant Health, as established by Normative Instruction 57 of December 11, 2013. Article. 3 This Normative Instruction shall come into force as of the date of its publication. JOSÉ GUILHERME TOLLSTADIUS LEAL TABLE -
World Mycotoxin Journal, February 2014; 7 (1): 3-33 Publishers
Wageningen Academic World Mycotoxin Journal, February 2014; 7 (1): 3-33 Publishers Developments in mycotoxin analysis: an update for 2012-2013 F. Berthiller1, P.A. Burdaspal2, C. Crews3, M.H. Iha4, R. Krska1, V.M.T. Lattanzio5, S. MacDonald3, R.J. Malone6, C. Maragos7, M. Solfrizzo5, J. Stroka8 and T.B. Whitaker9 1University of Natural Resources and Life Sciences, Vienna, Department for Agrobiotechnology (IFA-Tulln), Christian Doppler Laboratory for Mycotoxin Metabolism and Center for Analytical Chemistry, Konrad Lorenz Str. 20, 3430 Tulln, Austria; 2National Centre for Food, Spanish Food Safety and Nutrition Agency, Carretera de Majadahonda a Pozuelo km 5, 228220 Majadahonda, Spain; 3The Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, United Kingdom; 4Instituto Adolfo Lutz, Laboratrio I de Ribeiro Preto, Av Dr Arnaldo 355, CEP 14085-410, Ribeiro Preto SP, Brazil; 5Institute of Sciences of Food Production, National Research Council, Via Amendola 122/o, Bari 700126, Italy; 6Trilogy Analytical Laboratory, 870 Vossbrink Drive, Washington, MO 63090, USA; 7USDA, ARS National Center for Agricultural Utilization Research, 1815 N. University St., Peoria, IL 61604, USA; 8Institute for Reference Materials and Measurements (IRMM), European Commission Joint Research Centre, Retieseweg 111, 2440 Geel, Belgium; 9Biological and Agricultural Engineering Department, N.C. State University, P.O. Box 7625, Raleigh, NC 27695-7625, USA; [email protected] Received: 12 September 2013 / Accepted: 2 December 2013 © 2014 Wageningen Academic Publishers REVIEW ARTICLE Abstract This review highlights developments in mycotoxin analysis and sampling over a period between mid-2012 and mid-2013. It covers the major mycotoxins: aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone. -
014875 01 APP Mycotoxins in Cereals
APPLICATION NOTE Liquid Chromatography/ Mass Spectrometry Authors: PerkinElmer Applications Team PerkinElmer, Inc. Shelton, CT Determination of Mycotoxins in Cereals by LC-MS/MS Introduction Mycotoxins are toxic secondary with Online SPE metabolites produced by fungi, and are capable of causing disease and death in both humans and animals. As such, many countries and regions have regulations and applicable permissible limits in place for mycotoxin detection and identification (Table 1). Sample preparation is a critical step in the successful analysis of mycotoxins in food matrices. The “dilute and shoot” approach is a quick and easy way to introduce the sample into the LC/MS/MS analysis. However, due to the complexity of food matrices, this approach will often result in irreproducible matrix effects. Other sample prep techniques, such as offline solid phase extraction (SPE) and QUECHERS, require multiple time-consuming steps, and are prone to procedural and operator error. To overcome these problems and improve sensitivity, this work utilizes the addition of online solid phase extraction (SPE), coupled to an LC/MS/MS system for sample enrichment. This approach allows for significant and efficient analyte concentration, obviating the need for elaborate and time-consuming sample preparation procedures. Table 1. Global maximum regulatory limits (µg/kg or ppb) for mycotoxins in processed cereal products intended for human consumption. Mycotoxin EU USA China Singapore Brazil Sum of Aflatoxin B1, B2, G1 and G2 4 20 N/A 5 5 Aflatoxin B1 Only -
Mycotoxin-Degradation Profile of Rhodococcus Strains
International Journal of Food Microbiology 166 (2013) 176–185 Contents lists available at SciVerse ScienceDirect International Journal of Food Microbiology journal homepage: www.elsevier.com/locate/ijfoodmicro Mycotoxin-degradation profile of Rhodococcus strains M. Cserháti a,B.Kriszta,⁎,Cs.Krifatona,S.Szoboszlaya,J.Háhnb,Sz.Tóthc,I.Nagyd,J.Kukolyae a Szent István University, Department of Environmental Protection and Environmental Safety, 1 Páter Károly street, Gödöllő, 2100, Hungary b Szent István University, Regional University Center of Excellence in Environmental Industry, 1 Páter Károly street, Gödöllő, 2100, Hungary c Soft Flow Hungary R&D Ltd., 20 Kedves street, Pécs, 7628, Hungary d Max Planck Institute of Biochemistry, Department of Structural Biology, Planegg-Martinsried, Germany e Central Environmental and Food Science Research Institute, Department of Microbiology, 15 Herman Otto Street, Budapest 1022, Hungary article info abstract Article history: Mycotoxins are secondary fungal metabolites that may have mutagenic, carcinogenic, cytotoxic and endo- Received 4 March 2013 crine disrupting effects. These substances frequently contaminate agricultural commodities despite efforts Received in revised form 24 May 2013 to prevent them, so successful detoxification tools are needed. The application of microorganisms to biode- Accepted 6 June 2013 grade mycotoxins is a novel strategy that shows potential for application in food and feed processing. In Available online 22 June 2013 this study we investigated the mycotoxin degradation ability of thirty-two Rhodococcus strains on economi- cally important mycotoxins: aflatoxin B , zearalenone, fumonisin B , T2 toxin and ochratoxin A, and moni- Keywords: 1 1 tored the safety of aflatoxin B1 and zearalenone degradation processes and degradation products using Aflatoxin B1 Zearalenone previously developed toxicity profiling methods.