GC–MS-Based Urinary Organic Acid Profiling Reveals Multiple
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Dibasic Acids for Nylon Manufacture
- e Report No. 75 DIBASIC ACIDS FOR NYLON MANUFACTURE by YEN-CHEN YEN October 1971 A private report by the PROCESS ECONOMICS PROGRAM STANFORD RESEARCH INSTITUTE MENLO PARK, CALIFORNIA CONTENTS INTRODUCTION, ....................... 1 SUMMARY .......................... 3 General Aspects ...................... 3 Technical Aspects ..................... 7 INDUSTRY STATUS ...................... 15 Applications and Consumption of Sebacic Acid ........ 15 Applications and Consumption of Azelaic Acid ........ 16 Applications of Dodecanedioic and Suberic Acids ...... 16 Applications of Cyclododecatriene and Cyclooctadiene .... 17 Producers ......................... 17 Prices ........................... 18 DIBASIC ACIDS FOR MANUFACTURE OF POLYAMIDES ........ 21 CYCLOOLIGOMERIZATIONOF BUTADIENE ............. 29 Chemistry ......................... 29 Ziegler Catalyst ..................... 30 Nickel Catalyst ..................... 33 Other Catalysts ..................... 34 Co-Cyclooligomerization ................. 34 Mechanism ........................ 35 By-products and Impurities ................ 37 Review of Processes .................... 38 A Process for Manufacture of Cyclododecatriene ....... 54 Process Description ................... 54 Process Discussion .................... 60 Cost Estimates ...................... 60 A Process for Manufacture of Cyclooctadiene ........ 65 Process Description ................... 65 Process Discussion .................... 70 Cost Estimates ...................... 70 A Process for Manufacture of Cyclodecadiene -
8342 RA Rosin Flux Paste
8342 RA Rosin Flux Paste MG Chemicals UK Limited Version No: A-1.0 2 Issue Date: 12/08/2019 Safety Data Sheet (Conforms to Regulation (EU) No 2015/830) Revision Date: 14/01/2021 L.REACH.GBR.EN SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING 1.1. Product Identifier Product name 8342 Synonyms SDS Code: 8342; 8342-50G | UFI: MKH0-J0US-C00M-20WV Other means of identification RA Rosin Flux Paste 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses flux paste Uses advised against Not Applicable 1.3. Details of the supplier of the safety data sheet Registered company name MG Chemicals UK Limited MG Chemicals (Head office) Heame House, 23 Bilston Street, Sedgely Dudley DY3 1JA United Address 9347 - 193 Street Surrey V4N 4E7 British Columbia Canada Kingdom Telephone +(44) 1663 362888 +(1) 800-201-8822 Fax Not Available +(1) 800-708-9888 Website Not Available www.mgchemicals.com Email [email protected] [email protected] 1.4. Emergency telephone number Association / Organisation Verisk 3E (Access code: 335388) Emergency telephone numbers +(44) 20 35147487 Other emergency telephone +(0) 800 680 0425 numbers SECTION 2 HAZARDS IDENTIFICATION 2.1. Classification of the substance or mixture Classification according to regulation (EC) No 1272/2008 H334 - Respiratory Sensitizer Category 1, H319 - Eye Irritation Category 2, H317 - Skin Sensitizer Category 1 [CLP] [1] Legend: 1. Classified by Chemwatch; 2. Classification drawn from Regulation (EU) No 1272/2008 - Annex VI 2.2. Label elements Hazard pictogram(s) SIGNAL WORD DANGER Hazard statement(s) H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. -
An Improved Synthesis of Carbamates
DECEMBER,1963 AN IMPROVEDSYNTHESIS OF CARBAMATES 342 1 tion, extraction with methylene chloride, and removal of the sol- (V), m.p. 223-224". The reaction mixture had a strong odor of vent a small amount of white solid. This solid was recrystallized mesitol, but no attempt was made to isolate it. twive from hexane to yield white needles of a-t-butoxy-a-mesityl- 2-Mesity1-lj3-indandionewith Diphenyliodonium Chloride .- acetophenone-0-carboxylic acid, m.p. llE~116~. To a solution of 84.8 mg. (0.76 mmole) of potassium t-butoxide in Anal. Calcd. for CZZHZ~~O~:C, 74.55; H, 7.39; mol. wt., 20 ml. of t-butyl alcohol there was added with stirring 200 mg. 354.43. Found: C, 74.50; H, 7.36; mol. wt., 392 and 311. (0.76 mmole) of l' and 243 mg. (0.76 mmole) of diphenyliodo- Removal of the &Butyl Group in Compound VI.-A solution of nium chloride. The orange solution was refluxed overnight, dur- 250 mg. of VI in 15 ml. of dioxane and 5 ml. of 6 N hydrochloric ing which time it turned a light yellow, and all the iodonium cation acid was heated on a steam bath for 2 hr. During this time the was consumed. The solvent was removed, and the residue was solution was reduced to half the volume, with formation of light chromatographed on a 100-g. Florid column. The ether eluate ivory colored needles. The mixture was diluted with 25 ml. of yielded a yellow oil which after two distillations at 180-200' water, the solid was collected and chromatographed on silica gel. -
The Human Urine Metabolome
The Human Urine Metabolome Souhaila Bouatra1, Farid Aziat1, Rupasri Mandal1, An Chi Guo2, Michael R. Wilson2, Craig Knox2, Trent C. Bjorndahl1, Ramanarayan Krishnamurthy1, Fozia Saleem1, Philip Liu1, Zerihun T. Dame1, Jenna Poelzer1, Jessica Huynh1, Faizath S. Yallou1, Nick Psychogios3, Edison Dong1, Ralf Bogumil4, Cornelia Roehring4, David S. Wishart1,2,5* 1 Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, 2 Department of Computing Sciences, University of Alberta, Edmonton, Alberta, Canada, 3 Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 4 BIOCRATES Life Sciences AG, Innsbruck, Austria, 5 National Institute for Nanotechnology, Edmonton, Alberta, Canada Abstract Urine has long been a ‘‘favored’’ biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex. However, this chemical complexity has also made urine a particularly difficult substrate to fully understand. As a biological waste material, urine typically contains metabolic breakdown products from a wide range of foods, drinks, drugs, environmental contaminants, endogenous waste metabolites and bacterial by-products. Many of these compounds are poorly characterized and poorly understood. In an effort to improve our understanding of this biofluid we have undertaken a comprehensive, quantitative, metabolome-wide characterization of human urine. This involved both computer-aided literature mining and comprehensive, quantitative experimental assessment/validation. The experimental portion employed NMR spectroscopy, gas chromatography mass spectrometry (GC-MS), direct flow injection mass spectrometry (DFI/LC-MS/MS), inductively coupled plasma mass spectrometry (ICP-MS) and high performance liquid chromatography (HPLC) experiments performed on multiple human urine samples. -
Revised Group Additivity Values for Enthalpies of Formation (At 298 K) of Carbon– Hydrogen and Carbon–Hydrogen–Oxygen Compounds
Revised Group Additivity Values for Enthalpies of Formation (at 298 K) of Carbon– Hydrogen and Carbon–Hydrogen–Oxygen Compounds Cite as: Journal of Physical and Chemical Reference Data 25, 1411 (1996); https://doi.org/10.1063/1.555988 Submitted: 17 January 1996 . Published Online: 15 October 2009 N. Cohen ARTICLES YOU MAY BE INTERESTED IN Additivity Rules for the Estimation of Molecular Properties. Thermodynamic Properties The Journal of Chemical Physics 29, 546 (1958); https://doi.org/10.1063/1.1744539 Critical Evaluation of Thermochemical Properties of C1–C4 Species: Updated Group- Contributions to Estimate Thermochemical Properties Journal of Physical and Chemical Reference Data 44, 013101 (2015); https:// doi.org/10.1063/1.4902535 Estimation of the Thermodynamic Properties of Hydrocarbons at 298.15 K Journal of Physical and Chemical Reference Data 17, 1637 (1988); https:// doi.org/10.1063/1.555814 Journal of Physical and Chemical Reference Data 25, 1411 (1996); https://doi.org/10.1063/1.555988 25, 1411 © 1996 American Institute of Physics for the National Institute of Standards and Technology. Revised Group Additivity Values for Enthalpies of Formation (at 298 K) of Carbon-Hydrogen and Carbon-Hydrogen-Oxygen Compounds N. Cohen Thermochemical Kinetics Research, 6507 SE 31st Avenue, Portland, Oregon 97202-8627 Received January 17, 1996; revised manuscript received September 4, 1996 A program has been undertaken for the evaluation and revision of group additivity values (GAVs) necessary for predicting, by means of Benson's group additivity method, thermochemical properties of organic molecules. This review reports on the portion of that program dealing with GAVs for enthalpies of formation at 298.15 K (hereinafter abbreviated as 298 K) for carbon-hydrogen and carbon-hydrogen-oxygen compounds. -
Water Feed Methods to Control Mw Distribution and Byproducts of the Carbamylation of Urea
(19) TZZ _T (11) EP 2 949 687 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 02.12.2015 Bulletin 2015/49 C08G 71/02 (2006.01) C08G 63/48 (2006.01) (21) Application number: 15167165.8 (22) Date of filing: 11.05.2015 (84) Designated Contracting States: (72) Inventors: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB • Anderson, Jeff R. GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO Midland, Michigan 48642 (US) PL PT RO RS SE SI SK SM TR • Daryoosh, Beigzadeh Designated Extension States: Midland, Michigan 48640 (US) BA ME • Yiyong, He Designated Validation States: Midland, Michigan 48642 (US) MA • Congcong, Lu Midland, Michigan 48640 (US) (30) Priority: 29.05.2014 US 201462004545 P (74) Representative: Houghton, Mark Phillip (71) Applicant: Dow Global Technologies Llc Patent Outsourcing Limited Midland, MI 48674 (US) 1 King Street Bakewell, Derbyshire DE45 1DZ (GB) (54) WATER FEED METHODS TO CONTROL MW DISTRIBUTION AND BYPRODUCTS OF THE CARBAMYLATION OF UREA (57) The present invention provides methods for carbamylation catalysts. The polycarbamate of the making a polycarbamate by feeding a) a urea in fluid form present invention when combined with a polyaldehyde into areaction medium containing b)an alkyd polyol, such or an acetal or hemiacetal thereof as a second compo- as a short or med oil alkyd polyol to form a reaction mix- nent makes a multicomponent composition that is sub- ture and then carbamylating the alkyd polyol by heating stantially isocyanate-free, and cures at a temperature of the reaction mixture while feeding water in to the reaction from 0 °C to less than 80 °C to form a crosslinked poly- mixture, preferably, in the presence of one or more c) urethane. -
United States Patent Office Patented Aug
2,716,133 United States Patent Office Patented Aug. 23, 1955 2 process not covered by either of the two foregoing inven tions. The invention disclosed here describes these im 2,716,133 provements. - PURFICATION AND SEPARATION OF The water phase, containing mixed dicarboxylic acids DICARBOXYLIC ACDS as well as all the impurities previously listed (a, b, c, d, g, and h), is evaporated so that the solids content of the Leo S. Pooler, Chicago, Ill., assignor- to The C. P. Hall solution is increased to between 60% and 85% while Company of Illinois, Chicago, Ill., a corporation of being blown vigorously with air to effect further oxida Ohio tion. No Drawing. Application June 21, 1950, The dicarboxylic acid solution is then delivered to the Serial No. 169,542 crystallizer where it is cooled slowly to develop large crystals, after which the slurry is filtered and the crystals 6 Claims. (CI. 260-537) are washed. The mother liquor, is returned to the re actor for further oxidation. Small amounts of di This invention relates to the purification of dicar ; carboxylic acids are found in the mother liquor. boxylic acids produced from the oxidation of Saturated, The crude dicarboxylic acids coming from the filters unsaturated and substituted fatty acids. It includes the contain the same impurities as previously listed (a, b, c, use of the dichlorobenzenes (either pure Substances d, g, and h), but in lesser amounts than before the con or a mixture of the isomers) for the separation and puri centration, crystallization and filtration. fication of these -
The Fabrication and Characterization of Metal Oxide Nanoparticles Employed in Environmental Toxicity and Polymeric Nanocomposite Applications
University of Kentucky UKnowledge Theses and Dissertations--Chemical and Materials Engineering Chemical and Materials Engineering 2019 THE FABRICATION AND CHARACTERIZATION OF METAL OXIDE NANOPARTICLES EMPLOYED IN ENVIRONMENTAL TOXICITY AND POLYMERIC NANOCOMPOSITE APPLICATIONS Matthew Logan Hancock University of Kentucky, [email protected] Author ORCID Identifier: https://orcid.org/0000-0001-8492-3512 Digital Object Identifier: https://doi.org/10.13023/etd.2020.007 Right click to open a feedback form in a new tab to let us know how this document benefits ou.y Recommended Citation Hancock, Matthew Logan, "THE FABRICATION AND CHARACTERIZATION OF METAL OXIDE NANOPARTICLES EMPLOYED IN ENVIRONMENTAL TOXICITY AND POLYMERIC NANOCOMPOSITE APPLICATIONS" (2019). Theses and Dissertations--Chemical and Materials Engineering. 112. https://uknowledge.uky.edu/cme_etds/112 This Doctoral Dissertation is brought to you for free and open access by the Chemical and Materials Engineering at UKnowledge. It has been accepted for inclusion in Theses and Dissertations--Chemical and Materials Engineering by an authorized administrator of UKnowledge. For more information, please contact [email protected]. STUDENT AGREEMENT: I represent that my thesis or dissertation and abstract are my original work. Proper attribution has been given to all outside sources. I understand that I am solely responsible for obtaining any needed copyright permissions. I have obtained needed written permission statement(s) from the owner(s) of each third-party copyrighted matter to be included in my work, allowing electronic distribution (if such use is not permitted by the fair use doctrine) which will be submitted to UKnowledge as Additional File. I hereby grant to The University of Kentucky and its agents the irrevocable, non-exclusive, and royalty-free license to archive and make accessible my work in whole or in part in all forms of media, now or hereafter known. -
Certificate of Analysis
National Institute of Standards and Technology Certificate of Analysis Standard Reference Material® 2277 Organic Acids in Methanol:Methylene Chloride This Standard Reference Material (SRM) is a solution of 24 organic acids in methanol:methylene chloride. This SRM is intended primarily for use in the calibration of chromatographic instrumentation used for the determination of organic acids. A unit of SRM 2277 consists of five 2 mL ampoules, each containing approximately 1.2 mL of solution. Certified Concentrations of Constituents: The certified concentration values and estimated uncertainties for the 24 constituents, expressed as mass fractions, are given in Table 1 along with the Chemical Abstract Service (CAS) Registry Numbers. The certified concentration values are based on results obtained from the gravimetric preparation of this solution and from the analytical results determined by using gas chromatography. A NIST certified value is a value for which NIST has the highest confidence in its accuracy in that all known or suspected sources of bias have been investigated or accounted for by NIST. Expiration of Certification: The certification of SRM 2277 is valid, within the measurement uncertainties specified, until 31 December 2017, provided the SRM is handled and stored in accordance with the instructions given in this certificate (see “Instructions for Use”). The certification is nullified if the SRM is damaged, contaminated, or otherwise modified. Maintenance of SRM Certification: NIST will monitor this SRM over the period of its certification. If substantive technical changes occur that affect the certification before the expiration of this certificate, NIST will notify the purchaser. Registration (see attached sheet) will facilitate notification. -
Spectra Library Index Ichem/SDBS Raman Library
Ichem / SDBS Raman スタンダードライブラリー 株式会社 エス・ティ・ジャパン S p e c t r a L i b r a r y I n d e x (Ver. 40) Ichem / SDBS Raman Library ライブラリー名:ラマンスタンダードライブラリー 商品番号:60001-40 株式会社 エス・ティ・ジャパン 〒103-0014 東京都中央区日本橋蛎殻町 1-14-10 Tel: 03-3666-2561 Fax:03-3666-2658 http://www.stjapan.co.jp 1 【販売代理店】(株)テクノサイエンス Tel:043-206-0155 Fax:043-206-0188 https://www.techno-lab-co.jp/ Ichem / SDBS Raman スタンダードライブラリー 株式会社 エス・ティ・ジャパン ((1,2-DIETHYLETHYLENE)BIS(P-PHENYLENE))DIACETATE ((2-(3-BENZYLSULFONYL-4-METHYLCYCLOHEXYL)PROPYL)SULFONYLMETHYL)BENZENE ((2,4,6-TRIOXOHEXAHYDRO-5-PYRIMIDINYL)IMINO)DIACETIC ACID ((2-CARBOXYETHYL)IMINO)DIACETIC ACID ((2-HYDROXYETHYL)IMINO)DIACETIC ACID ((2-NITROBENZYL)IMINO)DIACETIC ACID ((2-SULFOETHYL)IMINO)DIACETIC ACID ((3-(1-BROMO-1-METHYLETHYL)-7-OXO-1,3,5-CYCLOHEPTATRIEN-1-YL)OXY)DIFLUOROBORANE ((N-BENZYLOXYCARBONYL-L-ISOLEUCYL)-L-PROLYL-L-PHENYLALANYL)-N(OMEGA)-NITRO-L-ARGININE 4-NITROBENZYL ESTER (-)-2-AMINO-1-BUTANOL (-)-2-AMINO-6-MERCAPTOPURINE RIBOSIDE (-)-6,8-P-MENTHADIEN-2-OL (-)-DIACETYL-L-TARTARIC ACID (-)-DIBENZOYL-L-TARTARIC ACID (-)-DI-P-ANISOYL-L-TARTARIC ACID (-)-DI-P-TOLUOYL-L-TARTARIC ACID (-)-KAURENE (-)-MENTHOL (-)-MYRTENOL (-)-N,N,N',N'-TETRAMETHYL-D-TARTARDIAMIDE (-)-N,N'-DIBENZYL-D-TARTRAMIDE (+)-1,3,3-TRIMETHYLNORBORNANE-2-ONE (+)-2-(2,4,5,7-TETRANITRO-9-FLUORENYLIDENEAMINOOXY)PROPIONIC ACID (+)-2-AMINO-1-BUTANOL (+)-2-PINENE (+)-3,9-DIBROMOCAMPHOR (+)-3-CARENE (+)-5-BROMO-2'-DEOXYURIDINE (+)-AMMONIUM 3-BROMO-8-CAMPHORSULFONATE (+)-CAMPHOR (+)-CAMPHOR OXIME (+)-CAMPHORIC ACID (+)-CATECHIN (+)-DI-P-ANISOYL-D-TARTARIC -
British Chemical Abstracts
BRITISH CHEMICAL ABSTRACTS A.-PURE CHEMISTRY SEPTEMBER, 1927. General, Physical, and Inorganic Chemistry. Symmetrical character of the terms corre 5016 Â. increases approximately linearly with the sponding with systems containing similar voltage in the range above 11 kilovolts. Intensities particles, derived by quantum dynamics. F, were measured by comparison with a standard lamp. H und (Z. Physik, 1927, 43, 788— 804).—Mathe R. W. Ltjnt. matical. ' R. W. L u n t . Ionisation potential.and the fine line spectrum Applications of Schrödinger’s theory to the of hydrogen. K. F. N i e s s e n (Z. Physik, 1927, 43, structure of spectra. E. W e i g e r (Z. Physik, 1927, 694—706).—The ionisation potential of hydrogen has 43, 624—652).—Mathematical. The characteristic been calculated by the use of half quantum numbers structure of spectra, in particular the laws of series assigned to the ion H2+ ; it is shown that some of the spectra and the Stark and Zeeman effects, have been fine-line spectrum is attributable to this ion. The derived by application of Schrödinger’s differentia] value calculated for the ionisation potential is equations. R. W. L u n t . — l-216iüA(=15 volts), in good agreement with that calculated by Burrau by wave mechanics — 1-204IÎA Orbits and light-radiation of hydrogen (=15-4 volts) (Kgl. Danske Videnskab. Selsk. math.- E n g s e t electrons. T. (Ann. Physik, 1927, [iv], 83, fys. Medd., 1927, 7, 14). R. W. L t jn t . 903—904).—Extensive mathematical corrections to a former paper (this vol., 601) are given. -
Novel Retinoid Derivatives and an Anti-Cancer Pharmaceutical Composition Comprising Said Compounds
(19) & (11) EP 1 390 343 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C07C 235/78 (2006.01) 14.10.2009 Bulletin 2009/42 (86) International application number: (21) Application number: 02728253.2 PCT/KR2002/001014 (22) Date of filing: 29.05.2002 (87) International publication number: WO 2002/096857 (05.12.2002 Gazette 2002/49) (54) NOVEL RETINOID DERIVATIVES AND AN ANTI-CANCER PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPOUNDS NEUE RETINOIDDERIVATE UND EINE PHARMAZEUTISCHE ANTI-KREBS- ZUSAMMENSETZUNG, DIE DIESE VERBINDUNGEN ENTHÄLT NOUVEAUX DERIVES DE RETINOIDE ET COMPOSITION PHARMACEUTIQUE ANTI-CANCER RENFERMANT LESDITS COMPOSES (84) Designated Contracting States: • HAN, Hye-Sook AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU 50-44 Jungkok-dong MC NL PT SE TR Seoul 143-220 (KR) Designated Extension States: • KIM, So-Mi AL LT LV MK RO SI 306-501 Deayoudealim Apt. Cheju-si 690-012 (KR) (30) Priority: 29.05.2001 KR 2001029813 • KIM, Dong-Myong 20.03.2002 KR 2002015016 1330-1207 Mokdongshinsigaji Apt. Seoul 158-076 (KR) (43) Date of publication of application: •OH, Deok-Kun 25.02.2004 Bulletin 2004/09 301-103 Jugong Apt. Kyunggi-do 427-040 (KR) (73) Proprietor: Chebigen Co., Ltd. • PARK, Jong-Sup Seoul 135-080 (KR) 1-2202 Wooseong Apt. Seoul 135-270 (KR) (72) Inventors: •BAE, Tae-Sung • UM, Soo-Jong 139, Sooryong 108-102 Parktown Seoan Apt. Jeonlabuk-do 576-922 (KR) Kyunggi-do 463-020 (KR) • SIN, Hong-Sig (74) Representative: Grünecker, Kinkeldey, 103-1602 Woobang Apt.