molecules Article Synthesis and Positive Inotropic Activity of [1,2,4]Triazolo[4,3-a] Quinoxaline Derivatives Bearing Substituted Benzylpiperazine and Benzoylpiperazine Moieties Xue-Kun Liu 1,†, Long-Xu Ma 2,†, Zhi-Yu Wei 2, Xun Cui 3, Shi Zhan 4, Xiu-Mei Yin 2,* and Hu-Ri Piao 2,* 1 Tonghua Normal University , College of Pharmaceutical and Food Science, Tonghua 134002, China;
[email protected] 2 Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133000, China;
[email protected] (L.-X.M.);
[email protected] (Z.-Y.W.) 3 College of Medicine, Yanbian University, Yanji 133000, China;
[email protected] 4 State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130000, China;
[email protected] * Correspondences:
[email protected] (X.-M.Y.);
[email protected] (H.-R.P.); Tel.: +86-433-243-6019 (X.-M.Y.); +86-433-243-5003 (H.-R.P.); Fax: +86-433-243-5026 (X.-M.Y.); +86-433-243-5026 (H.-R.P.) † These authors contributed equally to this work. Academic Editor: Derek J. McPhee Received: 15 January 2017; Accepted: 8 February 2017; Published: 11 February 2017 Abstract: In an attempt to search for more potent positive inotropic agents, two series of [1,2,4]triazolo[4,3-a] quinoxaline derivatives bearing substituted benzylpiperazine and benzoylpiperazine moieties were synthesized and their positive inotropic activities evaluated by measuring left atrial stroke volume in isolated rabbit heart preparations. Several compounds showed favorable activities compared with the standard drug, milrinone.