DOCSLIB.ORG

Salivary Lactate Dehydrogenase (LDH) As a Marker for Radiation-Induced Mucositis in Head and Neck Cancers: a Preliminary Study

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Salivary Lactate Dehydrogenase (LDH) As a Marker for Radiation-Induced Mucositis in Head and Neck Cancers: a Preliminary Study Archive of SID Original Article Middle East Journal of Cancer; AOpcrtiol b2e0r1 290; 180;( 29)(:4 1):0 238-181-0294 Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study Arnadi R Shivashankara*, Raees Tonse**, Sucharitha Suresh***, Thomas George***, Mamidipudi Srinivasa Vidyasagar**, Suresh Rao****, Manjeshwar Shrinath Baliga**** ♦ *Departments of Biochemistry Father Muller Medical College, Mangalore, Karnataka, India **Radiation Oncology Father Muller Medical College, Mangalore, Karnataka, India ***Community Medicine, MBBS student, Father Muller Medical College, Mangalore, Karnataka, India ****Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India Abstract Background: In this study, we sought to understand the usefulness of salivary lactate dehydrogenase as a predictive marker for the development of radiation-induced mucositis. Methods: This was a prospective study with head and neck cancer patients who required curative radiotherapy (>60Gy). We collected patients’ saliva before the onset of radiation and after 2 Gy of radiation to assess lactate dehydrogenase levels. The patients received the stipulated oral and dental care. Data on incidence and severity of mucositis was collected using a preform sheet and oral mucositis assessment scale published by the Radiation Therapy Oncology Group throughout the 7-week treatment period. Results: Salivary lactate dehydrogenase increased with exposure to radiation (P<0.0001) and there was an observed association with mucositis severity ( P<0.0001; r = 0.515). Conclusion: The present results have established, for the first time, that salivary lactate dehydrogenase could be a useful predictive marker to understand the development of radiation-induced mucositis in patients with head and neck cancer. The proximity of the oral cavity for regular observation and saliva collection is an added advantage. ♦Corresponding Author: Keywords: Head and neck cancer, Salivary lactate dehydrogenase, Mucos itis ♦CMoarrnejessphownadri nSgh rAinuaththo rB: aliga, EPhlhD am Aghili, MD DReespeaarrtcmh eMnta nogfa loPrea tIhnosltoitguyte , Sofc hoOoln coof lMogeyd,i cinPeu,m Ispfwahealln , UMnainvgerasliotyr eo,f KMaerdniactaal kSac,i eInncdeisa , I5s7f5ah0a0n2 , Iran Introduction need radiation therapy during the Tel: +919-899914352422622946417 1 EmEmaila:i al:g mhislib_aellihgaam@@gmyaahiol.oc.ocmom Reports suggest that nearly 60% course of their treatment. However, of all people afflicted with cancers of the use of radiation is associated with the head and neck (H&N) region side effects and the development of Received: February 03, 2018; Accepted: September 08, 2018 www.SID.ir Archive of SID Salivary LDH as Marker for Radiation-induced Mucositis mucositis, which is characterized by inflammation environment. 8 Reports suggest that changes occur and pain of the mucosal surface membrane in the to salivary LDH levels in various oral radiosensitive oral mucosa that necessitates pathogeneses like gingivitis, periodontitis, and continuous medical care. 2-4 Oral mucositis is cancer. Hence, LDH is a useful marker in classified as tolerable (grades 1 and 2) and ascertaining the oral health of the individual. 10-15 intolerable (grades 3 and 4) depending on the Because ionizing radiation is cytotoxic, we severity. 3 While tolerable mucositis is clinically hypothesize that increased levels of LDH will be manageable, intolerable mucositis impairs diet, observed in cases with increased severity of affects quality of life, increases morbidity, and loss mucositis. We have conducted this study to of weight. 2-4 ascertain the role of salivary LDH in predicting From a cellular perspective, mucositis affects radiation-induced mucositis in H&N cancer the integrity of the mucosal barrier. It increases the patients who undergo curative cisplatin based chances for microbial growth and may lead to chemo-irradiation. systemic infections that are difficult to treat in immunocompromised cancer patients. 2-4 The Materials and Methods development of mucositis is a very complex We conducted this study from January 2012 to process. Studies have shown that the incidence and July 2013 in the Departments of Radiation severity of mucositis depend on patient related Oncology and Biochemistry at Father Muller factors like age, gender, body mass index, alcohol Medical College, Mangalore, Karnataka, India. and tobacco use, oral hygiene, stage of disease, The subjects consisted of histopathologically white blood cell count, salivary rate, and normal confirmed adult H&N cancer patients scheduled flora of the mouth in addition to extrinsic factors to receive curative chemoradiotherapy (60-70 like dose per fraction, total dose, overall treatment Gy). Table 1 lists the exclusion and inclusion duration, use of chemo-irradiation, and criteria. The Institutional Ethics Committee fractionation schedule. 5,6 However, none of these approved this study. factors have a predictive value and cannot predict if the patient will develop mucositis and, more Radiation treatment importantly, its severity during the course of the The participants of the study were scheduled radiation treatment. to receive external irradiation at an average energy Research in the area of diagnostics suggests that level of 6 MeV from a linear accelerator (Varian the biochemical endpoint from the site of treatment Medical Systems, Unique 2012, Palo Alto, CA, and/or body fluid is beneficial. 7 As H&N cancers USA). Planned treatment included a curative pertain to the early part of the digestive tract and target dose of 60-70 Gy, 5 days per week without encompass the easily accessible oral cavity, the any intended gap, and no more than one fraction saliva produced in this region is a useful body per day of 2 Gy for 6-7 consecutive weeks. fluid, especially in ailments of the oral cavity. 8 Patients received their cisplatin infusion (50 2 16,17 Saliva collection does not need skilled personnel mg/m /day; IV) as per standard guidelines. or special equipment and is non-invasive. Lactate dehydrogenase (LDH), a crucial Saliva collection enzyme in metabolism, is involved in catalyzing During the first visit, we explained the nature the reversible conversion of pyruvate and lactate and purpose of the study to eligible patients who during glycolysis and gluconeogenesis. 9 Lactate satisfied the inclusion criteria. The explanations dehydrogenase is present in the cell cytoplasm in were provided in either English or the patients’ normal healthy conditions. However, exposure mother tongue (Kannada, Tulu or Malayalam) of the cell to a cytotoxic agent leads to cell rupture by one of the investigators. The subjects were and release of LDH into the extracellular informed that they had the right to withdraw from www.SID.ir Middle East J Cancer 2019; 10(2): 103-110 104 ArchiveArnadi R S hofivas hSIDankara et al. the study at any time during the study and non- spectrophotometer (Shimadzu, Japan). The LDH willingness to participant in the study would not assay was performed according to the kinetic deprive them of the necessary planned treatment. spectrophotometric method described by The patients who consented were then included Demetriouet al. 19 using a reagent kit obtained in the study after they provided a written informed from Roche Diagnostics. The assay was based on consent to participate. an LDH-catalyzed reduction of pyruvate with Unstimulated saliva was collected in NADH to form NAD+. The rate of oxidation of accordance with the method suggested by NADH to NAD+ was measured as a decrease in Navazesh at two time points: i) before the start of absorbance at 340 nm and expressed in terms of radiation treatment (day 0) before exposure to units/mg of protein. We used the internal and the first 2 Gy fraction and ii) 24 h after external quality control program from Biorad to administration of the first 2 Gy fraction and prior ensure accuracy and precision of the LDH values. to the second 2 Gy fraction. Each patient was asked to thoroughly rinse Clinical evaluation for mucositis the mouth area with distilled water to remove Mucositis grading any food debris. After 10 min, the patients were One of the investigators (RT) assessed the requested to salivate into a sterile plastic cup. degree of mucositis before the start of treatment Salivary flow rate (mL/min) was measured by and weekly during the radiation treatments in the following formula: 18 accordance with Radiation Therapy Oncology Group (RTOG) guidelines. The severity of oral Weight of container with saliva (g) -Weight of container without saliva (g) Duration of saliva collection mucositis was graded from 0 to 4 based on the RTOG guidelines. 3 Grades 0, 1 and 2 were The collected saliva was immediately ‘tolerable’ and grades 3 and 4 were ‘intolerable’ transported to the Biochemistry Laboratory in an forms of mucositis. 3 Calibration of assessment was ice box. The collected saliva was centrifuged at not required because only one researcher evaluated 3000 rpm for 10 minutes, and the supernatants the patients throughout the study period. were stored in a freezer (-20ºC). All patients were provided with the standard oral, dental, and medical supportive care. Patients LDH in saliva were provided with a 1:100 povidone-iodine The stored saliva was removed from the solution (1 mL of Betadine and 100 mL of water) freezer, thawed, and analyzed using appropriate as recommended by Madan and co-workers. 20 blanks, controls, and standards in a UV-visible Patients were requested to perform oral cleanings Figure 1. Incidence of different grades of mucositis during the 7- Figure 2. Average mucositis during the 7-week treatment course week treatment course for head and neck (H&N) cancers treated with for head and neck (H&N) cancers treated with radiation (>60 Gy). radiation (>60 Gy). RTOG: Radiation Therapy Oncology Group. RTOG: Radiation Therapy Oncology Group. www.SID.ir 105 Middle East J Cancer 2019; 10(2): 103-110 Archive of SID Salivary LDH as Marker for Radiation-induced Mucositis Table 1. Inclusion and exclusion criteria for study patient selection. Inclusion criteria Exclusion criteria 1. Age >18 years 1. Unwilling to be a part of the study. 2.
Load more

Recommended publications
  • 20/10/2020 Government of Karnataka Page:363
    20/10/2020 GOVERNMENT OF KARNATAKA PAGE:363 DEPARTMENT OF PRE UNIVERSITY EDUCATION LIST OF PU COLLEGES IN UDUPI DISTRICT AS ON 20/10/2020 ******************************************************************************** SLNO COLCD NAME AND ADDRESS YEAR OF OPEN & COLL TYPE OPENING & AIDED GO NOS. WITH DATE ******************************************************************************** 4882 SU0012 GOVT PU COLLEGE 71-72 GOVT PU COL PALIMAR ED 40 SLB 70 DT 30-04-1971 UDUPI TQ 574112 -------------------------------------------------------------------------------- 4883 SU0013 GOVT PU COLLEGE GOVT PU COL HEJAMADI UDUPI TQ 574103 -------------------------------------------------------------------------------- 4884 SU0021 POORNAPRAJNA PU COLLEGE 60-61 BIFUR PU COL UDUPI 576101 -------------------------------------------------------------------------------- 4885 SU0023 SVS PU COLLEGE 72-73 AIDED PU COL KATAPADI ED 19 TPU 72 DT 16-05-1972 UDUPI TQ 574105 ED 43 UDC 71 DT 07/08/1972 -------------------------------------------------------------------------------- 4886 SU0024 MAHATMAGANDHI MEMO PU COL 49-50 BIFUR PU COL UDUPI ROP 44 DZ 7/50-51 DT 5-10-1950 576102 -------------------------------------------------------------------------------- 4887 SU0025 GOVT PU COLLEGE 72-73 GOVT PU COL HIRIADKA UDUPI TQ 576113 -------------------------------------------------------------------------------- 4888 SU0026 MANIPAL PU COLLEGE 72-73 AIDED PU COL VIDYANAGAR MANIPAL ED 43 UDC 71 DT 07-08-1972 UDUPI TQ 576119 ED 43 UDC 71 DT 07/08/1972 --------------------------------------------------------------------------------
    [Show full text]
  • 826 Original Article Postprandial Somnolence and Its Awareness
    Bangladesh Journal of Medical Science Vol. 20 No. 04 October’21 Original article Postprandial Somnolence and its awareness among the Medical Undergraduate Students: A cross- sectional study Abhishek Chaturvedi1, Anitha Guru2, Naveen Kumar3, Ling Yi Lin4, Daniel YeapTze Wei5, Lai Kah Sheng6, Leow Hjun Yee7 Abstract Introduction: Postprandial somnolence or commonly referred to as food coma is generally experienced after the ingestion of afternoon meals. The performance of an individual gets affected after the ingestion of a heavy meal and this is more pertinent in a college setup where students have to attend a lecture right after the meal. The objective of this study was to assess the awareness of medical students about the factors responsible for postprandial somnolence, to identify the methods used to counteract it and to ascertain lecturers’ perception on responsiveness and participation of the students in a post lunch lecture. Methods: Total 330 students (first year to third year MBBS students) aged between 18-21 years and 40 lecturers teaching first and second year MBBS students were involved in this study. Two separate questionnaires (Part A: students’ perception, and B: lecturers’ perception) were prepared, peer-reviewed, validated and administered to the respective participants. All the responses were compiled and expressed in frequency percentage. Statistical analysis was performed using Statistical Package for Social Sciences, version 15.0 for a level of statistical significance of 5%. Pearson correlation was used to get the association between the variables. Results: About 55.75% students were aware about the role of serotonin and melatonin in drowsiness but 45.75% students did not know that food rich in tryptophan relaxes the brain and results in sleepiness.
    [Show full text]
  • DATED THIS the 27Th DAY of SEPTEMBER 2013 PRESENT THE
    - 1 - IN THE HIGH COURT OF KARNATAKA AT BANGALORE DATED THIS THE 27 th DAY OF SEPTEMBER 2013 PRESENT THE HON’BLE MR.JUSTICE DILIP B.BHOSALE AND THE HON’BLE MR.JUSTICE B.MANOHAR COMPANY APPEAL NO.5/2012 c/w COMPANY APPEAL Nos.6/2012, 7/2012, 8/2012, 9/2012 & 10/2012 IN COMPANY APPEAL NO.5/2012 BETWEEN: 1.SEA ROCK INVESTMENTS LIMITED, SYNDICATE HOUSE, UPENDRA NAGAR, MANIPAL-576104 2.RAJMAHAL TRADE & INVESTMENTS PRIVATE LIMITED SYNDICATE HOUSE, UPENDRA NAGAR, MANIPAL-576104 3.ANIL SUNIL TRADE & INVESTMENTS PRIVATE LIMITED NO.701, NORTH BLOCK MANIPAL CENTRE 47, DICKENSON ROAD, BANGALORE-560042 …APPELLANTS (BY SRI.ASHOK HARANAHALLI, SR.ADV. FOR SRI. P.N.MANMOHAN, ADV.) AND: 1.CHITRAKALA INVESTMENT TRADE & BUSINESS FINANCE LIMITED - 2 - SYNDICATE HOUSE, UPENDRA NAGAR, MANIPAL-576104 2.SRI TONSE SUDHAKAR PAI S/O T. RAMESH PAI AGED 59 YEARS R/A NO.5, CHITRAKALA, ANANTHNAGAR MANIPAL, UDUPI, KARNATAKA-576104 3.SRI R. MURALIDHAR RAO S/O T. NARAYANA RAO AGED 82 YEARS R/A NO.11, MEGHA MALHAR, VIDYARATNANGAR, MANIPAL, UDUPI, KARNATAKA-576104 4.SRI GARNET ALBERT REGO S/O GRATIAN CHARLES REGO AGED 77 YEARS R/A 19B, KRISHNAPUR COLONY, MANIPAL, UDUPI, KARNATAKA-576104 5.SRI SHASHINDRA BHAT S/O RAMAKRISHNA S BHAT AGED ABOUT 47 YEARS R/A H.NO. 5-96, BADAGABETTA, UDUPI, KARNATAKA-576119 6.SMT. JAYA S. PAI W/O T. SUDHAKAR PAI AGED 55 YEARS R/A CHITRAKALA, ANANTHNAGAR, MANIPAL, KARNATAKA-576104 7.SRI KAPPPETTU PRAKASH SHETTY S/O K. NARAYANA SHETTY AGED 61 YEARS RAMANI, SARALABETTU, MANIPAL, KARNATAKA-576104 8.SRI P.P.
    [Show full text]
  • District Census Handbook, Udupi, Part XII-A & B, Series-30
    CENSUS OF INDIA 2001 SERIES - 30 KARNATAKA PART XII - A & B : VILLAGE AND TOWN DIRECTORY & PRIMARY CENSUS ABSTRACT DISTRICT CENSUS HANDBOOK UDUPI DIRECTORATE OF CENSUS OPERATIONS, KARNATAKA,BANGALORE MOT -DMrid Stt~'$ 'Silhrurrull ii:s lkorcm1lJ.orll Ime4llf ~ ;a :sJImlllll w!IniirdIn IImIllre iitt ttlhe 'S!DdIiiestt: ({l)if aIIIl1tlbYe ii'SibmInll'S :amrdl giiwe tt:IDWYII!l «\)jf ttlhe~. lTlt iis uiir.dl ttlbmtt: ~ iitt :l!l 1tJruIle Soo1tltil Sea tOIDD.:oxum:. ~ ttIhm: :l!lllle ~ ;mmH lbmti\rrdl iiJm 11498 «lDll rnre «\)jf ~ iislli2ll1lulls \\\VlInDdIn line ~ sallitiiih :are mUlw gIDll)wwu lhmne.. fie ~ ii'S ~ fM "!Ell P'cadrlOO c&e Saonltat M;anU'_ llit ii'S ifino>m ttlInii'S ttlhalt Ulbrese iitt-s ifamooJrs lI:ro!rs:allit IrtOY.ck$., \\WIIniirdIn Ihmw: ~d iitmnlID D:s_.dl$ ~ 1IlIneiiJr ~ mtme_. TIney;:me jjrumt ;a br tOIDlhm!l!lll1l!'£ cammIl .'SlP'lliitt iilm1nol ~ mIDlMliic.. lP~ ~ JlDlRIDjeatitmm; @ mIDdk lriisiilmg \OOlIl1: @fttlhe ~ ttl1niis ii'S ltlhre (QDD]]Y ~ m1Jim:dtii;a ~ ~ mdks m(j)w «(l)j[ AIr_fum Sea IrIOXllllllrdi <allMxmtt: M;m])p.e.. "'Ulme ~ 1IlIJP> m ~ jp)~ if(jj)~. lflIl):(lQ: iisTharrmll ii'S ~ ;a :sqJ_turmre mmiiIke iilm area DWI lIllM mnrOlfIf: ttlhrm_ 15(0) y.anndk; iiIm wMirdhtlIn.. lIlt Jhm; (()1l):Q00JIlIlt ~ D I s T INDIA KARNATAKA DISTRICT UDUPI Km 5 o 5 [0 [5 Km Ul C.D. Block boundary of Udupi is co-terminus o -with laluk boundary , TOTAL AREA OF DISTRICT (IN SQ.KM) __ _______ __ 38.880.00 ..... -. TOTAL POPULATION OF DISTRICT ____________ __ __ 1.112.243 I TOTAL NUMBER OF TOWNS IN" DISTRICT •••• __ ._ .06 :"- TOTAL NU MBER OF VILLAGES [N DISTRICT _____ .
    [Show full text]
  • DETAILED PUBLIC HEARING DOCUMENT for Expansion of 2X600 MW TPP to 2800 MW by Addition of 2X800 MW (ULTRA SUPER CRITICAL UNITS) AT
    Expansion of 2x800 MW (Phase II) Udupi Thermal Power Project, Yelluru, Dist. Udupi, Karnataka DETAILED PUBLIC HEARING DOCUMENT FOR Expansion of 2x600 MW TPP to 2800 MW by Addition of 2x800 MW (ULTRA SUPER CRITICAL UNITS) AT PLACE : Paniyuru Durga Devi Higher Primary School Ground VILLAGE : YELLURU TAULK&DISTRICT : UDUPI APPLICANT: Udupi Power Corporation Limited (A subsidiary of Adani Power Limited) Yelluru village, Pilar Post, Udupi District – 574 138. Karnataka PHONE: +91 0820 2703500 EMAIL : [email protected] 1 Expansion of 2x800 MW (Phase II) Udupi Thermal Power Project, Yelluru, Dist. Udupi, Karnataka Public Hearing Consultation: As per the Environmental Impact Assessment (EIA) Notification dated 14th September 2006 read with amendments, the proposed thermal power plant project falls under ‘Category A’ with project or activity type number ‘1(d)’, which requires prior EIA for Environmental Clearance (EC) from the Ministry of Environment, Forest and Climate Change (MoEF&CC), Govt. of India. M/s. UPCL has obtained the Terms of Reference (ToR) from MoEF&CC for EIA of proposed 2x800 MW units. Hence, UPCL approached CSIR-NEERI, Nagpur to conduct EIA study for the purpose. The present EIA report addresses the environmental impacts of the proposed power plant and suggests mitigation measures, environmental management plan along with environmental monitoring program. The EIA report is prepared based on the ToR issued by MoEF&CC, vide letter no. J- 13012/12/2015-IA (T), dated 13, August 2015. After the preparation of Draft EIA in accordance of ToR letter the Public Hearing for this project of “1600 MW (2×800 MW) Coal Based Thermal Power Plant based on Ultra-Super Critical Technology” in notified industrial area at villages Yelluru and Santhuru, Taluka Udupi, Dist.
    [Show full text]
  • Karnataka Circle Cycle III Vide Notification R&E/2-94/GDS ONLINE CYCLE-III/2020 DATED at BENGALURU-560001, the 21-12-2020
    Selection list of Gramin Dak Sevak for Karnataka circle Cycle III vide Notification R&E/2-94/GDS ONLINE CYCLE-III/2020 DATED AT BENGALURU-560001, THE 21-12-2020 S.No Division HO Name SO Name BO Name Post Name Cate No Registration Selected Candidate gory of Number with Percentage Post s 1 Bangalore Bangalore ARABIC ARABIC GDS ABPM/ EWS 1 DR1786DA234B73 MONU KUMAR- East GPO COLLEGE COLLEGE Dak Sevak (95)-UR-EWS 2 Bangalore Bangalore ARABIC ARABIC GDS ABPM/ OBC 1 DR3F414F94DC77 MEGHANA M- East GPO COLLEGE COLLEGE Dak Sevak (95.84)-OBC 3 Bangalore Bangalore ARABIC ARABIC GDS ABPM/ ST 1 DR774D4834C4BA HARSHA H M- East GPO COLLEGE COLLEGE Dak Sevak (93.12)-ST 4 Bangalore Bangalore Dr. Dr. GDS ABPM/ ST 1 DR8DDF4C1EB635 PRABHU- (95.84)- East GPO Shivarama Shivarama Dak Sevak ST Karanth Karanth Nagar S.O Nagar S.O 5 Bangalore Bangalore Dr. Dr. GDS ABPM/ UR 2 DR5E174CAFDDE SACHIN ADIVEPPA East GPO Shivarama Shivarama Dak Sevak F HAROGOPPA- Karanth Karanth (94.08)-UR Nagar S.O Nagar S.O 6 Bangalore Bangalore Dr. Dr. GDS ABPM/ UR 2 DR849944F54529 SHANTHKUMAR B- East GPO Shivarama Shivarama Dak Sevak (94.08)-UR Karanth Karanth Nagar S.O Nagar S.O 7 Bangalore Bangalore H.K.P. Road H.K.P. Road GDS ABPM/ SC 1 DR873E54C26615 AJAY- (95)-SC East GPO S.O S.O Dak Sevak 8 Bangalore Bangalore HORAMAVU HORAMAVU GDS ABPM/ SC 1 DR23DCD1262A44 KRISHNA POL- East GPO Dak Sevak (93.92)-SC 9 Bangalore Bangalore Kalyananagar Banaswadi GDS ABPM/ OBC 1 DR58C945D22D77 JAYANTH H S- East GPO S.O S.O Dak Sevak (97.6)-OBC 10 Bangalore Bangalore Kalyananagar Kalyananagar GDS ABPM/ OBC 1 DR83E4F8781D9A MAMATHA S- East GPO S.O S.O Dak Sevak (96.32)-OBC 11 Bangalore Bangalore Kalyananagar Kalyananagar GDS ABPM/ UR 1 DR26EE624216A1 DHANYATA S East GPO S.O S.O Dak Sevak NAYAK- (95.8)-UR 12 Bangalore Bangalore St.
    [Show full text]
  • Annual-Day-Report-2014-15-For-21-2
    ANNUAL REPORT 2014-15, PRESENTED BY THE PRINCIPAL AT THE COLLEGE ANNUAL DAY FUNCTION HELD ON 21 FEBRUARY 2015 Respected H.H. Shri Vishwavallabha Theertha Swamiji, H. H. Shri Vishwesha Theertha Swamiji, Sri Ananthakrishna, other dignitaries on & off the dais, invited guests, colleagues, parents & students; its my pride & privilege to present before you, the valued annual report 2014-15 of SMVITM, Bantakal. I am proud to mention that an engineering institution of repute, established with a sublime objective of providing holistic professional education that bridges social gaps and empowers all segments of the society to approach the future with optimism and hope, is Shri Madhwa Vadiraja Institute of Technology & Management, Bantakal. Today, is a day of retrospection! SMVITM, Bantakal, established in the year 2010, has emerged as an engineering institution with distinction, a promising institution of the coastal region providing value added, quality education in engineering, an institution striding towards excellence! With the lofty Vision and Mission, several steps are being undertaken for multi- dimensional growth of the institution and effective industry-institute interface. Thanks to His Holiness Shri Vishwavallabha Theertha Swamiji of Shri Sode Vadiraja Mutt, Udupi, the founder of SMVITM! He dreamt of uplift of the underprivileged in the form of basic education, in general and technical education, in particular. His dream is being realized today! SMVITM Family: We have 1472 students on roll (as on date), of which 222 are in the fourth year, 394 in the third year, 449 in the second year and 407 in the first year of four BE courses, namely Civil Engg., Mechanical Engg., Electronics & Communication Engg.
    [Show full text]
  • 29/01/2020 Government of Karnataka Page:364
    29/01/2020 GOVERNMENT OF KARNATAKA PAGE:364 DEPARTMENT OF PRE UNIVERSITY EDUCATION LIST OF PU COLLEGES IN UDUPI DISTRICT AS ON 29/01/2020 ******************************************************************************** SLNO COLCD NAME AND ADDRESS YEAR OF OPEN & COLL TYPE OPENING & AIDED GO NOS. WITH DATE ******************************************************************************** 4888 SU012 GOVT PU COLLEGE 71-72 GOVT PU COL PALIMAR ED 40 SLB 70 DT 30-04-1971 UDUPI TQ 574112 -------------------------------------------------------------------------------- 4889 SU013 GOVT PU COLLEGE GOVT PU COL HEJAMADI UDUPI TQ 574103 -------------------------------------------------------------------------------- 4890 SU021 POORNAPRAJNA PU COLLEGE 60-61 BIFUR PU COL UDUPI 576101 -------------------------------------------------------------------------------- 4891 SU023 SVS PU COLLEGE 72-73 AIDED PU COL KATAPADI ED 19 TPU 72 DT 16-05-1972 UDUPI TQ 574105 ED 43 UDC 71 DT 07/08/1972 -------------------------------------------------------------------------------- 4892 SU024 MAHATMAGANDHI MEMO PU COL 49-50 BIFUR PU COL UDUPI ROP 44 DZ 7/50-51 DT 5-10-1950 576102 -------------------------------------------------------------------------------- 4893 SU025 GOVT PU COLLEGE 72-73 GOVT PU COL HIRIADKA UDUPI TQ 576113 -------------------------------------------------------------------------------- 4894 SU026 MANIPAL PU COLLEGE 72-73 AIDED PU COL VIDYANAGAR MANIPAL ED 43 UDC 71 DT 07-08-1972 UDUPI TQ 576119 ED 43 UDC 71 DT 07/08/1972 --------------------------------------------------------------------------------
    [Show full text]
  • Salivary Parameters As Predictive Markers for Radiation-Induced Treatment Response in Head and Neck Cancers: an Investigational Study
    Original Article Middle East Journal of Cancer; April 2018; 9(2): 133-142 Salivary Parameters as Predictive Markers for Radiation-induced Treatment Response in Head and Neck Cancers: An Investigational Study Dipika Jayachander*, Arnadi Ramachandrayya Shivashankara**, Mamidipudi Srinivasa Vidyasagar***, Raees Tonse****, Sarita Pais*****, Ashwin DL Lobo** Sanath Kumar Hegde******, Suresh Rao******, Manjeshwar Shrinath Baliga******♦ *Department of Radiation Oncology, Apollo Hospital, Bengaluru, Karnataka, India **Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India ***Department of Radiotherapy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India ****Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India *****Department of Radiation Oncology, Narayana Hrudayalaya, Bengaluru, Karnataka, India ******Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India Abstract Background: This study evaluates the predictive significance of salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase in the treatment of head and neck cancer patients who undergo curative radiotherapy/chemoradiotherapy. Methods: The volunteers for the study included head and neck cancer patients that required curative radiotherapy/chemoradiotherapy. Patients provided saliva and blood samples before the start of radiation treatment and 24 hours after the first radiation fraction of 2 Gy (before the start of the second fraction). Samples
    [Show full text]
  • Tranche 2: Udupi Water Supply System (Package No. 02UDP01)
    Initial Environmental Examination Document stage: Final Project Number: 43253-027 February 2019 IND: Karnataka Integrated Urban Water Management Investment Program (Tranche 2) – Improvements for 24 x 7 Water Supply System – Distribution System for City Municipal Council in Udupi Package No: 02UDP01 Prepared by Karnataka Urban Infrastructure Development and Finance Corporation, Government of Karnataka for the Asian Development Bank. This final initial environmental examination is a document of the borrower. The views expressed herein do not necessarily represent those of ADB's Board of Directors, management, or staff, and may be preliminary in nature. Your attention is directed to the “terms of use” section of this website. In preparing any country program or strategy, financing any project, or by making any designation of or reference to a particular territory or geographic area in this document, the Asian Development Bank does not intend to make any judgments as to the legal or other status of any territory or area. Initial Environmental Examination Document stage: Final Project Number: 43253-027 February 2019 IND: Karnataka Integrated Urban Water Management Investment Program (Tranche 2) – Improvements for 24x7 Water Supply System – Distribution System for City Municipal Council, Udupi Package No: 02UDP01 Prepared by Karnataka Urban Infrastructure Development and Finance Corporation, Government of Karnataka for the Asian Development Bank. CURRENCY EQUIVALENTS (as of 11 May 2017) Currency unit – Indian rupee (₹) ₹1.00 = $0. 0149 $1.00
    [Show full text]
  • Udupi District Irrigation Plan at Glance 4
    1 Pradhan Mantri Krishi Sinchayee Yojana (PMKSY) Udupi District District Irrigation Plan Nodal Agency Joint Director of Agricullture Department of Agriculture Udupi Zilla Panchayat Rajathadri, Udupi 2016 District Irrigation plan-PMKSY 2 TABLE OF CONTENT Part I: Distric Irrigation Plan Udupi District Irrigation Plan at Glance 4 Chapter-I: District Irrigation Plan: Preamble 8 1.1 Prime Minister Krishi Sinchayee Yojana (PMKSY) 1.2 District Irrigation Plan (DIP) 1.3 Process and Methodology Chapter 2: General Description of the District 12 2.1Introduction 2.2 Physiographic Features of the District 2.3 Land Use Pattern 2.4 Soil Profile 2.5 Dem0graphy 2.6 Agriculture 2.7 Biomass and Livestock 2.8 Industry and Service Sectors Chapter 3: Water Scenario of Udupi District 26 3.1 Rainfalls and River Basins 3.2 Underground Water Resources 3.3 Water Requirement for Crop Production 3.4 Domestic Water Demand 3.5 Livestock Water Demand 3.6 Industrial Water Demand 3.7 Water Demand for Power Generation 3.8 Total Projected Water Demand 3.9 Water Resource Budget for Udupi District Chapter 4: Irrigation Development inthe District: Issues and Challenges 35 4.1 Source-wise Present Irigation Status 4.2 Crop-wise Irrigation Use 4.3 Irrigation Development: Issues and Challenges 4.4 SWOT Analysis Chapter 5: District Irrigation Plan (DIP) 41 5.1 Vision for DIP 5.2 Strategies 5.3 District Irrigation Plan Chapter 6: Implementation and Monitoring 47 Annexure: Tables 48 Part II: Supporting Statistical Tables District Irrigation plan-PMKSY 3 List of Tables 2.1 Taluk-wise
    [Show full text]
  • Issue 1 Vol 2 2019 JCI Mission and Vision JCI Creed MISSION We Believe
    JCI Brahmavara Sevame India, Zone XV Region C Newsletter Issue 1 Vol 2 2019 JCI Mission and Vision JCI Creed MISSION We believe . That, faith in God gives meaning and purpose to human life; To provide development opportunities That, the brotherhood of man transcends the sovereignty of nations; that empower young people to create That, economic justice can best be won by free men through free positive change. enterprise; VISION That, government should be of laws rather than of men; To be the leading global network of That, earth's great treasure lies in human personality; young active citizens. And that, service to humanity is the best work of life." President’s Note Team 2020 My JCI journey started on19th May, 2018 under the able leadership of JFM Joeal D’ Almeida, the Founder President of JCI Brahmavara Sevame. It was he, who conceived the dream of having JCI at Brahamvara to bring out the leadership quality of YOUNG Brahmvara. I feel very proud to be a founder member and also president for the year 2019. I had a very fruitful year interms of members actively involving in JCI programs, understanding what is JCI JC Leslia Soares JFM Gracy Smitha Barnes and mainly members supporting all the JCI Programs. President Secretary I took oath on 24th January, 2019 as the President of JCI Brahmavara Sevame. I wasn’t sure how to lead the team and where to aim. It was Founder President JFM Joeal D’ Almeida who suggested to build the team first then conduct the programs under JCI ban- ner.
    [Show full text]