PRODUCT DATA SHEET Bioworld Technology,Inc.

CCAR1 polyclonal antibody

Catalog: BS8140 Host: Rabbit Reactivity: Human

BackGround: by affinity-chromatography using epitope-specific im- CARP-1 (cell division cycle and apoptosis regulator 1), munogen and the purity is > 95% (by SDS-PAGE). also known as CCAR1 or DIS, is a 1,150 amino acid pro- Applications: tein that localizes to the perinuclear region of the cyto- WB 1:500 - 1:2000 plasm and contains one SAP domain. Expressed in sever- IF 1:50 - 1:200 al epithelial cancer cell lines, including breast, colon, IP 1:50 - 1:100 prostate and leukemia, CARP-1 is involved in apoptotic Storage&Stability: signaling, as well as in cell cycle progression and cell Store at 4°C short term. Aliquot and store at -20°C long proliferation via interaction with c-Myc and cyclin B1. term. Avoid freeze-thaw cycles. CARP-1 is subject to DNA damage-induced phosphory- Specificity: lation, probably by ATM or ATR. The encoding CCAR1 polyclonal antibody detects endogenous levels of CARP-1 maps to human 10, which houses CCAR1 . over 1,200 and comprises nearly 4.5% of the hu- DATA: man genome. Defects in some of the genes that map to are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, non- syndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and por- phyria.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, WesternBlot (WB) analysis of CCAR1 polyclonal antibody 50% glycerol, pH7.2 Note: Molecular Weight: For research use only, not for use in diagnostic procedure. ~ 155 kDa Swiss-Prot: Q8IX12 Purification&Purity: The antibody was affinity-purified from rabbit antiserum

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