PRODUCT DATA SHEET Bioworld Technology,Inc. CCAR1 polyclonal antibody Catalog: BS8140 Host: Rabbit Reactivity: Human BackGround: by affinity-chromatography using epitope-specific im- CARP-1 (cell division cycle and apoptosis regulator 1), munogen and the purity is > 95% (by SDS-PAGE). also known as CCAR1 or DIS, is a 1,150 amino acid pro- Applications: tein that localizes to the perinuclear region of the cyto- WB 1:500 - 1:2000 plasm and contains one SAP domain. Expressed in sever- IF 1:50 - 1:200 al epithelial cancer cell lines, including breast, colon, IP 1:50 - 1:100 prostate and leukemia, CARP-1 is involved in apoptotic Storage&Stability: signaling, as well as in cell cycle progression and cell Store at 4°C short term. Aliquot and store at -20°C long proliferation via interaction with c-Myc and cyclin B1. term. Avoid freeze-thaw cycles. CARP-1 is subject to DNA damage-induced phosphory- Specificity: lation, probably by ATM or ATR. The gene encoding CCAR1 polyclonal antibody detects endogenous levels of CARP-1 maps to human chromosome 10, which houses CCAR1 protein. over 1,200 genes and comprises nearly 4.5% of the hu- DATA: man genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, non- syndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and por- phyria. Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, WesternBlot (WB) analysis of CCAR1 polyclonal antibody 50% glycerol, pH7.2 Note: Molecular Weight: For research use only, not for use in diagnostic procedure. ~ 155 kDa Swiss-Prot: Q8IX12 Purification&Purity: The antibody was affinity-purified from rabbit antiserum Bioworld Technology, Inc. Bioworld technology, co. Ltd. Add： 1660 South Highway 100, Suite 500 St. Louis Park, Add： No 9, weidi road Qixia District Nanjing, 210046, MN 55416,USA. P. R. China. Email: [email protected] Email: [email protected] Tel: 6123263284 Tel: 0086-025-68037686 Fax: 6122933841 Fax: 0086-025-68035151 .