Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001806345Cyc: Acinetobacter baumannii KAB01 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari a metal a metal acinetobactin glutamate (2-aminoethyl) molybdate cation cation val asp phosphonate acetate acetate betaine ornithine Co 2+ his leu pro thr pro thr predicted predicted predicted ABC ABC ABC efflux transporter of RS13090 RS10160 RS05200 RS09975 RS00010 transporter RS00610 RS17380 RS10245 RS04465 transporter of RS16975 RS12175 ApbC RS16580 RS08620 RS19175 RS11885 RS08315 RS18955 RS08010 RS00555 RS15625 RS15565 RS02775 RS07710 MscL HtpX RS02690 RS07625 RS02655 RS07600 RS11465 AdeJ RS15230 RS02555 PgaD RS02550 TatB TatC RS11430 RS07480 RS02510 RS02485 RS00945 RS07385 RS02415 RS02400 RS15070 RS07270 ActP RS17955 CarO DmeF RS02375 RS07340 RS11365 YgaH RS05455 GltP RS02495 HisQ LeuE RS13205 PutP ProP RS13245 SstT RhtC (2-aminoethyl) RS15245 RS15685 RS15305 RS15320 RS15335 RS15360 RS02700 RS16205 RS07690 RS18565 RS02790 RS15580 RS07935 RS15735 RS19960 NreB RS08255 RS16225 RS16345 RS08705 RrtA RS03995 RS09080 RS17020 RS12350 RS10235 RS17295 RS09670 RS12620 RS17640 RS12720 RS17910 RS00280 RS10205 TssM RS07210 RS02275 RS02270 RS02155 RS02235 RS07155 RS07150 RS14880 RS02515 RS14860 RS07070 RS14760 RS14745 RS11205 RS14715 GspG GspF RS07075 RS14685 RS02035 RS06965 RS14680 RS14665 RS14660 RseP RS14635 RS14630 of molybdate acinetobactin phosphonate PhoR RS13250 val glycine betaine acetate acetate Co 2+ serine ornithine asp his leu pro pro thr acinetobactin a metal a metal thr (2-aminoethyl) molybdate cation cation glutamate RS18310 phosphonate RS13170

RS16305 porin RS13055 AdeG

N 6 -(3-methylbut- a carboxy- L-alanyl-γ-D- N-acetyl-D- UDP-N-acetyl- a [bis(guanylyl poly-β-1,6- an N-terminal- a peptide with N-acetyl-α- [2Fe-2S] iron-sulfur , Carrier, and Vitamin Biosynthesis a sulfurated UDP-N-acetyl- ubiquinol-8 biosynthesis flavin biosynthesis I (bacteria and plants) superpathway of heme b superpathway of adenosylcobalamin salvage from cobinamide I thioredoxin Fermentation L- degradation I Degradation 2-en-1-yl)- adenosylcobinamide a purine adenylated- glutamyl-meso-2,6- glucosamine α-D-glucosamine molybdopterin) α N-acetyl-D- shikimate L-quinate L-methionyl-L- an N-terminal D-muramoyl- cluster biosynthesis superpathway of tetrahydrofolate biosynthesis - Metabolic Regulator Biosynthesis mixed acid fermentation L- degradation I L- degradation I L- degradation I L- degradation I [sulfur carrier] cys cys -D-muramoyl- ATP roseoflavin RS15350 RS03420 RS18090 (early decarboxylation) biosynthesis from glutamate pathway Alcohol Degradation 37 ribonucleoside [ThiS sulfur- diaminopimeloyl- UDP-N-acetyl- cofactor γ glucosamine glucose/quinate/ glucose/quinate/ seryl-[] L- L-(1-) glutaredoxin L-alanyl- -D- 5'-phosphate RS13100 all-trans- in tRNA 5'-triphosphate carrier protein] D-alanine α-D-muramate chaperone]- glutamyl-meso-2,6- shikimate family shikimate family cob(II)inamide redox reactions ppGpp phosphoenolpyruvate val poly-beta-1,6 L- desulfurase octaprenyl GTP an oxidized ile leu tyr thr glycerol and glycerophosphodiester degradation L-cysteine diaminopimeloyl- membrane-bound membrane-bound 1,6-anhydro-N- GTP 4-hydroxybenzoate glu trehalose biosynthesis I bifunctional N-acetyl-D- poly-beta-1,6- type I methionyl type I methionyl diphosphate glutamate-- cob(I)yrinic acid glutathione thioredoxin bifunctional threonine ammonia- tRNA (N6-isopentenyl D-alanyl-D-alanine PQQ-dependent PQQ-dependent acetylmuramyl- bifunctional cysteine branched-chain branched-chain adenosylcobinamide IscS subfamily UDP-N- glucosamine N-acetyl-D- aminopeptidase: aminopeptidase: RS15525 RS08450 RS05280 tRNA : a,c-diamide pppGpp D-glucopyranose phosphoenolpyruvate branched-chain aspartate , biosynthetic: ilvA glycerol adenosine(37)-C2)- dehydrogenase: dehydrogenase: L-alanine riboflavin desulfurase: GTP bifunctional α amino acid amino acid L- degradation kinase/ cysteine acetylmuramate:L- synthase: IscS subfamily glucosamine map map 4-hydroxybenzoate KAB01_RS17445 adenosyltransferase: UDP- -D-glucose 6-phosphate carboxylase: ppc amino acid transaminase/ methylthiotransferase KAB01_RS10665 KAB01_RS10665 amidase kinase/FAD RS10220 KAB01_RS07940 cyclohydrolase 3,4-dihydroxy- an L-glutamyl- bifunctional (p)ppGpp transaminase: transaminase: threonine ammonia- II (AST pathway) adenosylcobinamide- desulfurase: alanyl-gamma-D- pgaC cysteine D-alanyl- N-deacetylase type I methionyl type I methionyl octaprenyltransferase: KAB01_RS15995 a reduced thioredoxin- transaminase: aspartate 4- MiaB: miaB AmpD: ampD synthetase: I FolE: folE 2-butanone- [tRNA Glu ] synthetase/guanosine- pyruvate KAB01_RS16140 4-methyl-2-KAB01_RS16140 lyase: KAB01_RS15540 phosphate KAB01_RS09005 glutamyl- meso- poly-beta-1,6 desulfurase: D-alanine PgaB: pgaB glucose/quinate/ glucose/quinate/ aminopeptidase: aminopeptidase: IscS subfamily ubiA [corrinoid glutaredoxin disulfide trehalose-6- KAB01_RS16140 decarboxylase: (2Z)-2-aminobut-2-enoate succinate ribF 7,8- 4-phosphate 3',5'-bis(diphosphate) 3'- oxaloacetate 3-methyl-2- oxopentanoate a glycerophosphodiester guanylyltransferase: cysteine diaminopimelate N-acetyl-D- KAB01_RS09005 endopeptidase poly-beta-1,6- shikimate family shikimate family map map cysteine glutamyl-tRNA adenosyltranferase]- glutaredoxin reductase: phosphate KAB01_RS12615 arg dehydrogenase, RS07920 RS08465 RS12930 dihydroneopterin synthase/GTP pyrophosphohydrolase: oxobutanoate (3S)-3-methyl-2- glycerol cobU desulfurase: ligase: mpl glucosamine cysteine PBP7/8: pbpG N-acetyl-D- membrane-bound membrane-bound N-acetyl-D- desulfurase: 4-hydroxy-3- reductase: cob(II)inamide 3: grxC trxB synthase: arginine N- hydrophobic roseoflavin 3'-triphosphate cyclohydrolase II: KAB01_RS17275 guanosine 3'- D-lactate oxopentanoate aspartate/ KAB01_RS07940 synthase: desulfurase: [+ 3 isozymes] glucosamine PQQ-dependent PQQ-dependent ala muramate RS13035 KAB01_RS09005 octaprenylbenzoate KAB01_RS04230 KAB01_RS04060 malate dehydrogenase: succinyltransferase: glycerophosphodiester membrane anchor adenosyl- an N-terminal adenine superpathway of thiamine diphosphate biosynthesis II KAB01_RS18430 glutathione- bifunctional (p)ppGpp diphosphate 5'- dehydrogenase: dld tyrosine/aromatic UDP-N-acetylmuramoyl- pgaC KAB01_RS07940 N-deacetylase dehydrogenase: dehydrogenase: met met a peptide KAB01_RS16505 2 astA phosphodiesterase: glycerol kinase protein: sdhD cobinamide L-seryl-[protein] an S-sulfanyl-[L- (S)-4-amino-5- dependent 3-methylbutanoyl- aminotransferase: N -succinyl- γ KAB01_RS15855 KAB01_RS15855 dinucleotide GTP cyclohydrolase a reduced synthetase/guanosine- triphosphate 3'- α α 2-iminobutanoate KAB01_RS16000 GlpK: glpK phosphate a purine a thiocarboxylated- L-alanyl- -D- UDP-N- PgaB: pgaB RS12885 cysteine desulfurase] oxopentanoate [corrinoid disulfide-bond , -trehalose acetyl-CoA formate CoA 3-(4- KAB01_RS00525 L-arginine TraW RS03665 7,8- thioredoxin 3',5'-bis(diphosphate) 3'- diphosphatase: (R)-lactate isobutanoyl-CoA (2S)-2- N 6 -(3-methylbut- ribonucleoside ala [ThiS sulfur- glutamyl-meso-2,6- β a [bis(guanylyl D-ala acetylmuramoyl- 3-dehydroshikimate 3-dehydroquinate nitrite nitrite cys II: ribA adenosyltranferase]- : 6-phosphate (S)-malate hydroxyphenyl) AMP poly- -1,6- UDP RS18605 scaffold dihydroneopterin glutamate-1- pyrophosphohydrolase: KAB01_RS03085 methylbutanoyl- isovaleryl-CoA N-succinylarginine 5'-deoxyadenosine 2-en-1-yl)-2- met an unsulfurated 5'-diphosphate carrier protein] diaminopimeloyl- ala molybdopterin) L-alanyl-γ-D- partially formate formate 2-octaprenylphenol 2,5-diamino-6-(5-phospho-D- cob(I)inamide yghU trehalose- pyruvate N-acetyl-D- protein for 3'-phosphate semialdehyde KAB01_RS03085 2-methylcitrate isobutyryl-CoA:FAD CoA dehydrogenase: dihydrolase: astB sn-glycerol 3-phosphate (methylsulfanyl) [sulfur carrier] D-alanine cofactor glutamyl-meso-2,6- acetate deacetylated poly- cysteine superpathway of thiamine diphosphate biosynthesis I ribosylamino)pyrimidin-4(3H)-one a protein with phosphatase: fumarate hydratase: phosphate glucosamine iron-sulfur 2,1- cob(I)yrinic acid synthase: prpC oxidoreductase: 2-methylbutanoyl- KAB01_RS07760 4-hydroxyphenylpyruvate 2 37 β desulfurase: 2-octaprenylphenol bifunctional reduced L- KAB01_RS02620 : pta N -succinyl- adenosine chaperone]-S- diaminopimeloyl- -1,6-N-acetyl- RS17900 cluster a [ThiS sulfur- aminomutase: a,c-diamide otsB citrate (Si)-synthase: gltA KAB01_RS00665 CoA 3-methylcrotonyl- dioxygenase: hppD 2-oxobutanoate glycerol-3-phosphate RS18010 KAB01_RS07940 hydroxylase: diaminohydroxyphosphoribosylaminopyrimidine cysteine residues class II fumarate L-ornithine in tRNA sulfanyl-L-cysteine D-alanine D-glucosamine RS18880 RS03975 assembly: iscU carrier protein] KAB01_RS01960 D-ribulose 5-phosphate hemL adenosyltransferase: α α acetaldehyde CO H dehydrogenase: CoA dehydrogenase: glpD D-erythro-7,8- cys deaminase/5-amino-6-(5-phosphoribosylamino) , -trehalose hydratase: fumC 2 2 methylacrylyl-CoA succinylornithine an S-sulfanyl-[cysteine IscS subfamily 3-(all-trans KAB01_RS15995 citrate acetyl phosphate KAB01_RS00665 homogentisate acetyl/propionyl/ transaminase: 6 γ dihydroneopterin cysteine bifunctional uracil reductase RibD: ribD 5-aminolevulinate GTP ppGpp (E)-2- DHAP a ring-opened 7- a mature peptidoglycan a [protein]- an O - a DNA containing (1S,2R)-1- L-alanyl- -D- an N-terminal- desulfurase]-[disordered- cysteine -octaprenyl) fumarate enoyl-CoA a lipid II 34 an L-asparaginyl- adenosylcobinamide bifunctional aconitate methylcrotonyl- KAB01_RS17075 methylguanine (meso-diaminopimelate methylguanine an apurinic/ ser C-(indol-3- glutamyl-meso- UDP-N-acetyl- a [- shikimate L-quinate L-methionyl-L- met a cytidine lys form scaffold dihydroneopterin desulfurase: benzene-1,2-diol 3,4-dihydroxy- 5-amino-6-(5-phospho- acetate kinase: methylcrotonoyl- 2 L-cysteine ATP [tRNA Asn ] RS00115 desulfurase: porphobilinogen hydratase 2/2- hydratase: CoA carboxylase N -succinyl- α synthetase]- in tRNA Ile2 protein] complex aldolase: folB KAB01_RS09005 a carboxy- 2-butanone- D-ribosylamino)uracil fumarate reductase/ KAB01_RS02630 CoA propanoyl-CoA in DNA containing) in DNA apyrimidinic site yl)glycerol diaminopimelate -D-muramate glucose/quinate/ glucose/quinate/ valyl-[protein] amino-acid N- RS00265 RS15725 RS16910 KAB01_RS07940 bifunctional 3- synthase: hemB bifunctional tetrahydrofolate salvage from methylisocitrate KAB01_RS00670 subunit alpha: L-glutamate 5- L-tyrosine [cysteine desulfurase]-S- chorismate an [L-cysteine adenylated- 4-phosphate bifunctional glycine betaine succinate dehydrogenase ethanol NADPH repair (prokaryotes) enoyl-CoA 4-maleyl- 3-phosphate shikimate family shikimate family acetyltransferase: 6-(hydroxymethyl) IscS subfamily demethylubiquinone 3- adenosylcobinamide 5,10-methenyltetrahydrofolate dehydratase: (S)-3-hydroxy- KAB01_RS16395 phosphate semialdehyde D-alanyl- sulfanylcysteine:[acceptor desulfurase]-S- [ThiS sulfur- synthase/GTP diaminohydroxyphosphoribosylaminopyrimidine biosynthesis I (Gram- flavoprotein subunit: acetate hydratase: acetoacetate bifunctional DNA- endolytic methylated-DNA-- endonuclease UDP-N- membrane-bound membrane-bound type I methionyl argA tRNA aminoacyl- -7,8-dihydropterin cysteine O-methyltransferase/2- porphobilinogen kinase/ KAB01_RS12210 isobutanoyl-CoA [+ 2 isozymes] propionyltransferase: pta succinylglutamate- D-alanine protein]-cysteine aminodeoxychorismate/ sulfanyl-L-cysteine carrier protein] cyclohydrolase II: deaminase/5-amino-6-(5-phosphoribosylamino) a 5,10- bifunctional (p)ppGpp negative bacteria) KAB01_RS09480 KAB01_RS00670 formamidopyrimidine transglycosylase [protein]-cysteine S- III: nth acetylmuramate:L- bifunctional [glutamate- PQQ-dependent PQQ-dependent aminopeptidase: lysidine(34) tRNA RS12715 desulfurase: octaprenyl-6-hydroxy adenosylcobinamide- NADPH (2S,3S)-3- maleylacetoacetate semialdehyde synthase: endopeptidase bifunctional sulfurtransferase: 2-amino-4-hydroxy-6- anthranilate synthase KAB01_RS18430 uracil reductase RibD: ribD methenyltetrahydrofolatebifunctional synthetase/guanosine- 3-methylglutaconyl- glycosylase/ MltG: mltG methyltransferase: alanyl-gamma-D- -ammonia ligase]- dehydrogenase: dehydrogenase: map synthetase : RS10420 RS18905 RS17035 KAB01_RS09005 phenol methylase: hydroxymethylbilane phosphate GDP choline succinate cis-aconitate hydroxy-2- : maiA propanoyl phosphate dehydrogenase: bifunctional DNA- KAB01_RS15955 PBP7/8: pbpG glutamate N- KAB01_RS09005 hydroxymethyldihydropteridine component II: cysteine methylenetetrahydrofolate 3',5'-bis(diphosphate) 3'- CoA DNA-(apurinic KAB01_RS01780 glutamyl- meso- adenylyl-L-tyrosine KAB01_RS15855 KAB01_RS15855 TilS: tilS pth a [cysteine desulfurase]- D-glyceraldehyde an [L-cysteine KAB01_RS00330 3,4-dihydroxy- 5-amino-6-(5-phospho- synthase: hemC guanylyltransferase: pyrophosphokinase: choline methylbutanoyl- astD [+ 3 isozymes] formamidopyrimidine trpB [+ 3 isozymes] type I methionyl acetyltransferase/ diphosphokinase: KAB01_RS13385 desulfurase: 2-methoxy- dehydrogenase/ pyrophosphohydrolase: bifunctional aconitate 4-fumaryl- or apyrimidinic methylated-DNA-- diaminopimelate phosphorylase/ S-sulfanyl-[disordered- desulfurase]-S- 2-butanone- D-ribitylamino)uracil cobU KAB01_RS03085 dehydrogenase: (S)-3-hydroxy- 2 glycosylase/ glucose/quinate/ glucose/quinate/ aminopeptidase: amino-acid KAB01_RS12275 KAB01_RS07940 3-phosphate KAB01_RS17275 CoA acetoacetate acetate kinase: N - tryptophan [glutamate-- 4-amino-4- 6-(all-trans- preuroporphyrinogen methenyltetrahydrofolate hydratase 2/2- isobutanoate site) lyase: mutM [protein]-cysteine S- ligase: mpl shikimate family shikimate family 34 AdeA form scaffold sulfanyl-L-cysteine 4-phosphate betA 2-methylacetoacetyl- KAB01_RS02630 succinylglutamate a mature peptidoglycan a mature peptidoglycan DNA-(apurinic a N- map acetyltransferase a lysidine 2-amino-4-hydroxy-6- deoxychorismate IscS subfamily 1-deoxy-D- octaprenyl)phenol adenosyl-cobinamide cyclohydrolase FolD: folD bifunctional (p)ppGpp methylisocitrate methyltransferase: synthase ammonia-ligase] Asn protein] complex cysteine synthase: ribB 10 betaine aldehyde 3-hydroxyisobutyrate fumarylacetoacetase: with (L-alanyl-γ-D- strand (non- or apyrimidinic membrane-bound membrane-bound ArgJ: argJ Ile2 asn tRNA hydroxymethyldihydropteridine xylulose-5- uroporphyrinogen- phosphate an N - (R)-NADPHX coenzyme A HMG-CoA succinylglutamate subunit adenylyltransferase: D-ala acetylglucosamine- in tRNA RS17895 RS16030 RS17040 cysteine aminodeoxychorismate cysteine gly desulfurase: synthetase/guanosine- dehydratase: bifunctional dehydrogenase: fahA a [DNA]- 2,6-diamino-4- glutamyl-meso-2,6- reducing terminus) KAB01_RS03500 site) lyase: mutM UDP-N-acetyl- PQQ-dependent PQQ-dependent N-acetyl-L- diphosphokinase: folK phosphate 1-deoxy-L-glycero- III synthase: formyltetrahydrofolate reductase: propanoate desuccinylase: astE a 5'-phospho- beta: trpB glnE -N-acetylmuramyl- an N-terminal desulfurase: lyase: pabC desulfurase: KAB01_RS07940 bifunctional 3',5'-bis(diphosphate) 3'- betaine-aldehyde KAB01_RS12210 ADP-dependent mmsB nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal diaminopimeloyl-D- α-D-muramoyl- dehydrogenase: dehydrogenase: methionine (7,8-dihydropterin- synthase: a [ThiS sulfur- tetrulose 4-phosphate ARP KAB01_RS01535 phosphoribosylglycinamide Glycolysis KAB01_RS12310 hydroxymethylglutaryl- [DNA] (tetrapeptide) met L-valyl-[protein] KAB01_RS07940 KAB01_RS09005 2-methoxy-6-all adenosylcobinamide 5,6-dimethylbenzimidazole pyrophosphohydrolase: dehydrogenase: NAD(P)H-hydrate fumarate 3'-phosphate formamidopyrimidine alanine) tetrapeptide a [protein]-S- L-alanyl-γ-D- KAB01_RS10665 KAB01_RS10665 RS17635 6-yl)methyl dxs IscS subfamily carrier protein] formyltransferase: D-threo-isocitrate (S)-methylmalonate- 2-methylacetoacetyl- CoA lyase: a guanine in DNA a 3'-terminal a 5'-phospho- D-glyceraldehyde pyrophosphoryl- IscS subfamily 4-aminobenzoate trans-octaprenyl- uroporphyrinogen-III kinase/ KAB01_RS03085 betB dehydratase/ glu methyl-L-cysteine glutamyl-meso-2,6- a [glutamine diphosphate a thiocarboxylated- 1-deoxy-D- cysteine KAB01_RS14600 semialdehyde CoA KAB01_RS07740 unsaturated sugar [DNA] 3-phosphate trp undecaprenol 3-dehydroshikimate 3-dehydroquinate RS11825 RS17255 cysteine 1,4-benzoquinol 6,7-dimethyl-8- adenosylcobinamide- nicotinate-nucleotide-- GDP glycolysis I (from glucose 6-phosphate) NAD(P)H-hydrate diaminopimelate synthetase]-O RS00080 [ThiS sulfur- xylulose 5- desulfurase: glycine betaine NADP-dependent desulfurase: 2-iminoacetate bifunctional ribityllumazine uroporphyrinogen phosphate dimethylbenzimidazole epimerase: acetoacetate L- degradation I 4 -(5'-adenylyl) dihydropteroate carrier protein] phosphate KAB01_RS09005 a tetrahydrofolate D-glucopyranose isocitrate dehydrogenase: methylmalonate- acetyl-CoA C- KAB01_RS09005 D-glyceraldehyde demethylmenaquinone synthase: ribE decarboxylase: guanylyltransferase: phosphoribosyltransferase: KAB01_RS08490 -L-tyrosine an S-sulfanyl-[cysteine synthase: folP a [ThiI sulfur- a carboxy- 6-phosphate KAB01_RS14140 semialdehyde RS09740 3-phosphate methyltransferase/2- KAB01_RS13465 cobU cobT (S)-NADPHX desulfurase]-S- thiazole synthase: carrier protein]- adenylated- NADP-dependent isocitrate dehydrogenase: FadA: fadA pro (S)-3-amino-2- L-tryptophan degradation to L-threonine 4 ω RS03480 PonA 7,8- KAB01_RS12940 1-deoxy-D- S-sulfanyl- [ThiS sulfur- methoxy-6-polyprenyl- 6,7-dimethyl-8-(1-D-ribityl)lumazine coproporphyrinogen III adenosylcobinamide- α glucose-6- dehydrogenase: icd KAB01_RS00650 a 7,8-dihydro- an O - a [ThiI sulfur- a peptide with a [glutamine an N-terminal- an N-terminal- an N-terminal- an N -(1- YidC sulfanyl-[disordered- AIR -ribazole 5'-phosphate bifunctional methylpropanoate trifunctional 2-amino-3-carboxymuconate degradation III (to an [HPr]- phosphoenol a [protein]- a [protein]- a DNA methyl L(or D)-O- an L-cysteinyl- dihydropteroate xylulose-5- tyr L-cysteine carrier protein] 1,4-benzoquinol GDP phosphate 8-oxoguanine methylthymine carrier protein]- cys an N-terminal synthetase]-O L-methionyl-L- L-methionyl-L- L-methionyl- hydroxy-2- NADH form scaffold ADP-dependent transcriptional semialdehyde methylglyoxal) L- pyruvate L-cysteine L-cysteine phosphotriester phosphoserine [tRNA Cys ] 2-[(2R,5Z)- phosphate methylase UbiE: ubiE riboflavin synthase: oxygen-dependent isomerase: 2-oxoglutarate acetyl-CoA propanoyl-CoA L-histidine degradation I in DNA in DNA 4 protein] complex bifunctional phosphomethylpyrimidine superpathway of coenzyme A biosynthesis I (bacteria) NAD(P)H-hydrate hydrogencarbonate regulator/proline L-cysteine Xaa-L-proline -(5'-adenylyl) threonyl-[protein] bifunctional alanyl-[protein] glycyl-[protein] oxopropyl) RS17495 [cysteine desulfurase]-S- 2-carboxy-4- synthase: 6-methoxy-3- KAB01_RS01350 coproporphyrinogen adenosylcobinamide- pgi -L-tyrosine -[protein]- tetrahydrofolate synthase ThiC: thiC dehydratase/ dehydrogenase/L- trp thr phosphoserine NAD(+) sulfanylcysteine:[acceptor methylthiazol-5(2H dxs methyl-2-all- oxidase: hemF GDP phosphoenolpyruvate- methylated-DNA-- methylated-DNA-- L-arginine RS08460 RS09775 synthase/ 3-methyl-2- a 5,10- NAD(P)H-hydrate his glutamate gamma- bifunctional DNA- IscS subfamily leucyl type I methionyl phosphatase/ type I methionyl type I methionyl diphosphatase: aminoacyl- AdeB protein]-cysteine )-ylidene]ethyl AIR 1-deoxy-D- a thiocarboxylated- trans-octaprenyl- riboflavin ribazoletransferase: F6P -protein [protein]-cysteine S- [protein]-cysteine S- dihydrofolate HMP-P protoporphyrinogen IX oxobutanoate methylenetetrahydrofolate epimerase: semialdehyde formamidopyrimidine cysteine aminopeptidase: bifunctional [glutamate- aminopeptidase: homoserine aminopeptidase: aminopeptidase: nudC tRNA sulfurtransferase: phosphate xylulose 5- 2-iminoacetate [ThiS sulfur- 1,4-benzoquinol KAB01_RS09160 histidine N-Formyl-L- phosphotransferase: ptsP methyltransferase: methyltransferase: synthase: folC phosphomethylpyrimidine bifunctional Aromatic Compound Biosynthesis KAB01_RS08490 ammonia- dehydrogenase: L-2-amino-3- glycosylase/ desulfurase: KAB01_RS01370 -ammonia ligase]- map phosphotransferase map map hydrolase: RS09575 a [cysteine KAB01_RS09005 hydroxymethylpyrimidine/ phosphate carrier protein] L-glutamate kynurenine phosphoenolpyruvate- KAB01_RS01780 KAB01_RS01780 7,8-dihydrofolate synthase ThiC: thiC riboflavin kinase/ protoporphyrinogen 3-methyl-2-oxobutanoate class 1 fructose- L-citrulline degradation lyase: hutH putA oxobutanoate DNA-(apurinic KAB01_RS09005 Xaa-Pro adenylyl-L-tyrosine type I methionyl ThrH: thrH type I methionyl type I methionyl reduced β- pth desulfurase]-(S- phosphomethylpyrimidine NADPH degradation II (S)-1-pyrroline- -protein methylated-DNA-- monoglutamate thiazole synthase: FAD synthetase: ribF oxidase HemJ: hemJ adenosylcobalamin hydroxymethyltransferase: chorismate biosynthesis I bisphosphatase: urocanate or apyrimidinic methylated-DNA-- cysteine aminopeptidase: phosphorylase/ aminopeptidase: phosphoserine aminopeptidase: aminopeptidase: nicotinamide D- RS16545 RS09800 sulfanyl) -[disordered- kinase: KAB01_RS04150 2-(2-carboxy-4- 5'-phosphate panB 2,3-dihydroxybenzoate 3-(4-hydroxyphenyl) KAB01_RS14550 5-carboxylate phosphotransferase: ptsP [protein]-cysteine S- [protein]-cysteine S- AMP RS17630 2 HMP-P site) lyase: mutM desulfurase: pepP [glutamate-- map map map KAB01_RS12940 3-demethylubiquinol-8 FMN biosynthesis Macromolecule Modification L-citrulline urocanate methyltransferase: phosphatase ribonucleotide form scaffold HMP-PP methylthiazol-5- protoporphyrin IX asp D-erythrose pyruvate biosynthesis glu methyltransferase: KAB01_RS07940 ammonia-ligase] a [protein]- cys a tRNA Cys RS17370 hydroxymethylpyrimidine/ pyrroloquinoline β-D-fructose 1,6- ornithine hydratase: an [HPr protein]- KAB01_RS03500 SerB: serB (R)-lactate protein] complex yl)ethyl phosphate 2-[(2R,5Z)- 3-demethylubiquinone- 4-phosphate aspartate/ L-kynurenine a [DNA]- KAB01_RS03500 adenylyltransferase: L-arginine phosphomethylpyrimidine quinone biosynthesis bifunctional ferrochelatase: 2-dehydropantoate 3-deoxy-7- chorismate bisphosphate tRNA-uridine 2-thiolation carbamoyltransferase: hutU aminoacetone a 5'-phospho- 7,8-dihydro- N π -phospho- pyruvate a peptide with an N-terminal L- serine an N-terminal L- an N-terminal a 7,8-dihydrofolate 2-carboxy-4- 8 3-O- riboflavin kinase/ aspartate 1- tyr DHAP queuosine biosynthesis I (de novo) tyrosine/aromatic nucleotide- 4-oxo-2-pentenal a proteinogenic glnE thiamine kinase: KAB01_RS04150 hemH phosphoheptulonate and selenation (bacteria) argF L-glutamate-5- [DNA] 8-oxoguanine L-histidine a [ThiI sulfur- an N-terminal met threonyl-[protein] met alanyl-[protein] met glycyl-[protein] RS17105 RS04965 methylthiazol-5(2H methyltransferase: FAD synthetase: ribF adenosylcobalamin decarboxylase: bifunctional fructose- carbamoyl aminotransferase: 4-imidazolone- primary- 3'-phosphate a [protein]-S- a [protein]-S- amino acid RS10335 phosphate a PqqA peptide SAM KAB01_RS04175 synthase: KAB01_RS00525 5-propanoate semialdehyde a thymine in DNA [DNA] ala carrier protein]- L-proline a [cysteine desulfurase]- dihydrofolate HMP-PP )-ylidene]ethyl KAB01_RS00330 aspartate bisphosphate phosphate amine methyl-L-cysteine methyl-L-cysteine a [glutamine- RS04595 synthase: FAD protoheme KAB01_RS09165 isochorismate cys preQ S-sulfanyl- [scaffold protein- reductase: phosphate transaminase/ triose-phosphate aldolase class II: 0 bifunctional : trifunctional oxidase: ADP synthetase]- KAB01_RS13025 ubiquinol-8 β-alanine 3-deoxy-7- NADPH-dependent 7- glutamine- L-cysteine (2Fe-2S)] complex KAB01_RS02500 γ (R)-pantoate aspartate 4- isomerase: KAB01_RS08675 aspartate KAB01_RS18485 transcriptional 3-hydroxy- tynA L-tyrosine glutamate C phosphoheptulonate : cysteine cyano-7-deazaguanine hydrolyzing RS17125 CsuB thiamine thiamine 3 pyridoxal 5'-phosphate biosynthesis I decarboxylase: KAB01_RS01865 transaminase/ regulator/proline L-kynurenine dihydrofolate -tyrosine C KAB01_RS14050 desulfurase: reductase QueF: queF carbamoyl- RS04825 cys RS07925 cys reductase: phosphate phosphate synthase: KAB01_RS12615 aspartate 4- N-formimino- dehydrogenase/L- methylglyoxal ligase: pqqE pantoate--beta- preQ phosphate γ 1498 synthase: D-erythrose KAB01_RS10800 acinetobactin KAB01_RS07940 1 L-glutamate : GlcNAc-1,6- an N-formyl-L- a mature an N-terminal- a peptidoglycan L-alanyl- -D- a uracil KAB01_RS10350 synthase: thiamine diphosphate salvage II 3-deoxy- decarboxylase: glutamate gamma- a peptidoglycan + an L-cysteinyl- a [co-chaperone]- alanine ligase: biosynthesis aspartate/ D-glyceraldehyde synthase: kynU a 5,10-gly a uridine 34 anhMurNAc-L-Ala- methionylaminoacyl- NADPH NAD peptidoglycan L-methionyl-L- dimer (E. faeciums) glutamyl-L-lysyl- asp γ-L-glutamyl- gly KAB01_RS14060 KAB01_RS13025 4-phosphate IscS subfamily KAB01_RS12615 semialdehyde (n) in 16S rRNA Pro KAB01_RS03120 D-arabino- tyrosine/aromatic 3-phosphate tRNA guanosine(34) carA carB formimidoylglutamase: γ ATP [tRNA ] [scaffold protein- a tetrahydrofolate a PqqA peptide with bifunctional cysteine dehydrogenase: methylenetetrahydrofolate in tRNA -D-Glu-DAP-D-Ala tRNA (meso-DAP cysteinyl-[protein] D-alanyl-D-alanine 16S rRNA biotin D-alanine RS12410 (2Fe-2S)] complex thiamine D-erythrose- 4-amino-2-methyl-5- heptulosonate aminotransferase: transglycosylase Tgt: tgt asp hutG 3-hydroxyanthranilate (uracil(1498)-N(3))- aspartate/ RS17320 RS05230 thiamine phosphate linked Glu-Tyr residues 4-phosphate pyrimidinemethanol 7-phosphate isochorismatase/ type I desulfurase: carbamate putA 1,6-anhydro-N- containing) D-alanyl- tyrosine/aromatic RS01390 SSQ1 3-(4- KAB01_RS00525 a 7-aminomethyl-7- L-methionine degradation NAD(P)(+) methyltransferase: phosphate synthase: dehydrogenase: (R)-pantothenate aryl carrier glyceraldehyde- KAB01_RS09005 aspartate tRNA uridine-5- acetylmuramyl- 1,6-anhydro-N- peptide type I methionyl D-alanine D-alanyl- aminotransferase: glutathione Cys- chaperone: adenosylcobalamin hydroxymethylpyrimidine/ 3-dehydroquinate hydroxyphenyl) 34 I (to L-) transhydrogenase bis(guanylyl molybdopterin) protein BasF: basF 3-phosphate an [L-cysteine deazaguanosine in tRNA glu glu carboxymethylaminomethyl(34) L-alanine acetylmuramyl- deformylase: aminopeptidase: KAB01_RS13295 biotin--[acetyl- synthase: tRNA(Pro) dnaK salvage from cobalamin thiamine- KAB01_RS14060 gap phosphomethylpyrimidine synthase: aroB pyruvate ammonia-lyase: (Re/Si-specific): endolytic endopeptidase D-alanine KAB01_RS00525 cofactor sulfurylation pantothenate (2S,3S)-2,3- dehydrogenase: desulfurase]-S- tRNA preQ1(34) S- L-tryptophan synthesis GTPase MnmE: mnmE amidase L-alanine KAB01_RS00975 map 16S rRNA CoA-carboxylase] gshB deacylase: RS17170 a [chaperone-ATP]- phosphate 4-phospho- kinase: KAB01_RS04150 KAB01_RS09525 L-serine degradation 2-amino-3- KAB01_RS03025 transglycosylase PBP7/8: pbpG endopeptidase 2-amino-4-[5-(2-amino- kinase: dihydroxy-2,3- gap sulfanyl-L-cysteine adenosylmethionine degradation I met AmpD: ampD amidase (uracil(1498)-N(3))- bifunctional ligase: ybaK RS09785 RS10170 [co-chaperone]- cob(I)alamin kinase: thiL thiamine D-erythronate 5-(2-hydroxyethyl) 3-dehydroquinate carboxymuconate- tRNA uridine-5- peptide KAB01_RS03030 MltG: mltG type I methionyl [+ 3 isozymes] PBP7/8: pbpG RS17300 2-carboxylatoethyl)-2- HMP-P KAB01_RS04015 dihydrobenzoate ribosyltransferase- CO (via anthranilate) fumarate methionine AmpD: ampD methyltransferase: aspartate KAB01_RS04020 [scaffold protein- cys phosphate 4-phosphoerythronate -4-methylthiazole glyceraldehyde- 2 6-semialdehyde carboxymethylaminomethyl(34) deformylase: KAB01_RS03035 [+ 3 isozymes] aminopeptidase: [+ 3 isozymes] thiamine hydroxyphenyl]pentanedioate (R)-4'- type I 3- isomerase QueA: queA ser adenosyltransferase: KAB01_RS18015 transaminase/ norophthalmate (2Fe-2S)] complex dehydrogenase: hydroxymethylpyrimidine/ 3-phosphate trp KAB01_RS08530 synthesis MnmG: mnmG ditrans,octacis- a peptidoglycan def map a peptidoglycan an N 3 - aspartate 4- diphosphate thiamine- hydroxyethylthiazole phosphopantothenate Si-specific NAD(P)(+) Pro cysteine dehydroquinate a [TusA sulfur- D-serine degradation L-serine L-aspartate N-acetyl-β-D- L-alanyl-γ-D- γ 1498 biotinyl-5'- cys a tRNA RS17120 cob(II)alamin phosphate KAB01_RS14755 phosphomethylpyrimidine dehydrogenase: an epoxyqueuosine 34 in tRNA SAM undecaprenyldiphospho- pentapeptide a mature GlcNAc-1,6- tetramer with a D-ala L-alanyl- -D- methyluracil decarboxylase: SSQ1 desulfurase: kinase: thiM bifunctional dehydratase: carrier protein]-S- ammonia-lyase: degradation I glucosamine-1,6- glutamyl-meso-2,6- transhydrogenase: adenylate RS09840 RS13945 kinase: KAB01_RS04150 2,3- KAB01_RS14250 34 N-acetyl-(N- peptidoglycan anhMurNAc- D,D cross-link glutamyl-L- D-ala in 16S rRNA KAB01_RS12615 KAB01_RS07940 kinase: thiL 2-amino-4-[3-(2-amino-2- (3R)-3-hydroxy-2-oxo- 4-methyl-5-(2- KAB01_RS10680 sulfanyl-L-cysteine a 5-carboxymethylaminomethyluridine a L-methionylaminoacyl- sthA (n) an N-terminal L- RS04565 chaperone cob(I)yrinic acid phosphopantothenoylcysteine dihydroxybenzoate epoxyqueuosine N-Formyl-L- 2-aminoprop-KAB01_RS07390 a 7,8-dihydrofolate acetylglucosaminyl)muramate anhydro-N-acetyl- diaminopimeloyl- formate (meso-DAP L-Ala-γ-D-Glu- met (Enterococcus lysyl-D-alanine thiamine carboxylatoethyl)-6-oxocyclohexa- 4 phosphooxybutanoate phosphooxyethyl) decarboxylase/ sulfurtransferase D-serine L-glutamine in tRNA β tRNA cysteinyl-[protein] oxaloacetate ATPase: dnaK a,c-diamide IscS subfamily HMP-PP type II 3- 13-DPG reductase QueH: kynurenine 2-enoate asp -D-muramate D-alanine containing) DAP-D-Ala faecium) diphosphate 1,4-dien-1-yl]pentanedioate 3-phosphoserine/ thiazole phosphopantothenate-- complex subunit D-serine degradation I adenosyltransferase: cysteine dehydroquinate KAB01_RS07305 + RS09210 a [chaperone- phosphohydroxythreonine TusD: tusD ammonia-lyase: aspartate/ NADH NADP KAB01_RS15995 desulfurase: cysteine ligase CoaBC: coaBC dehydratase: aroQ tRNA met RS08325 met CybC RS10830 an [2Fe-2S] ADP]-[disordered- transaminase: serC D-glyceraldehyde thiamine a [TusD sulfur- KAB01_RS05525 tyrosine/aromatic SAH cob(II)alamin- KAB01_RS09005 pyruvate (R)-4'- phosphoglycerate epoxyqueuosine(34) 2-aminoprop- gln cluster protein form scaffold 4-phosphooxy- 3-phosphate phosphate 3-dehydroshikimate carrier protein]-S- aminotransferase: [corrinoid an [L-cysteine 6-(2-amino-2-carboxylatoethyl) phosphopantothenoyl- phenylethanol biosynthesis kinase: reductase QueG: queG 2-enoate Asp-tRNA(Asn) protein] complex L-threonine synthase: NAD de novo biosynthesis sulfanyl-L-cysteine L-kynurenine 2-iminopropanoate KAB01_RS00525 3'-dephospho- (4R)-4-hydroxy- a (2E,4Z)-2,4- (E)-4-hydroxy-3- met RS08330 met adenosyltranferase] desulfurase]-S- -1,2,3,4-tetrahydroquinoline- L-cysteine KAB01_RS08665 /Glu-tRNA(Gln) : Reactive Blue 5 H O H + hydrogencarbonate a protein with glutathione oxaloacetate aci-nitroethane a RNA-DNA hybrid carbonic acid thiamine phosphate formation from shikimate diphosphate 2 methylbut-2-en- asp ser a tRNA sec RS17000 non- sulfanyl-L-cysteine 2,4-dicarboxylate 4-hydroxythreonine- 1-deoxy-D- KAB01_RS13025 I (from aspartate) bifunctional a queuosine 34 in tRNA bifunctional amidotransferase: KAB01_RS13285 ATP CoA a disulfide bond ITP 2-oxoglutarate dienoyl-CoA pyrithiamine and oxythiamine (yeast) dehydrogenase: 3-phospho- L-glutamine NADPH-dependent 1-yl diphosphate RS10380 RS11070 chaperonin cysteine 4-phosphate xylulose-5- thiamine phosphopantothenoylcysteine phe kynureninase: aspartate gatC gatA gatB flavodoxin- bifunctional met RS12530 met molecular desulfurase: aroE D-glycerate a [TusE sulfur degradation II transaminase/ 2,4-dienoyl- dependent cob(I)alamin- dehydrogenase phosphate phosphate asp decarboxylase/ kynU 2-iminopropanoate [+ 6 isozymes] L-homocysteine Dyp-type bifunctional SulP nitronate bifunctional bifunctional SulP aspartate chaperone KAB01_RS07940 pyrithiamine thiamine diphosphate salvage IV (yeast) [+ 2 isozymes] carrier protein]-S aspartate 4- RdgB/HAM1 family non- glutaredoxin ribonuclease CoA reductase: (E)-4-hydroxy- PdxA: pdxA synthase: dxs synthase: phosphopantothenate-- a uridine 34 in tRNA pyruvate glu peroxidase: family inorganic monooxygenase: 4-hydroxy-2- transaminase/ serine- [corrinoid 6-(2-amino-2-carboxylatoethyl) L-aspartate 2,3-bisphosphoglycerate- anthranilate canonical purine NTP triphosphoribosyl- phosphoenolpyruvate HII: rnhB KAB01_RS06365 family inorganic RS16920 ATPase: hscA IscS subfamily 3-amino-1- KAB01_RS14060 cysteine ligase CoaBC: coaBC shikimate aromatic amino -sulfanylcysteine gln decarboxylase: KAB01_RS00855 anion transporter/ 3: grxC KAB01_RS07650 oxoglutarate 3-methylbut- aspartate 4- -tRNA an [Fe-S cluster adenosyltranferase] bis(guanylyl -7-hydroxy-8-oxo-1,2,3,4,7,8- oxidase: nadB independent glutamate L- pyrophosphatase: rdgB dephospho- carboxykinase (GTP) anion transporter/ RS17135 cob(I)yrinic acid cysteine thiamine hydroxyacetone 1-deoxy-D-xylulose acid lyase: KAB01_RS12615 carbonic anhydrase: glutathione- aldolase/2- NADPH-dependent 2-enyl- decarboxylase: ligase: RS00075 RS14575 biosynthesis molybdopterin) II: tenA hexahydroquinoline- 2-iminosuccinate 4'-phosphopantetheine phosphoglycerate synthase large oxaloacetate degradation I Dyp-type inorganic CoA synthase: : KAB01_RS14910 nitronate carbonic a,c-diamide desulfurase: 1-phosphate 5-phosphate thiamine shikimate KAB01_RS02795 tRNA 2- KAB01_RS17555 dependent dehydro-3-deoxy- 2,4-dienoyl- diphosphate KAB01_RS12615 serS chaperone]-ATP cofactor 4-amino-2-methyl-5- 2,4-dicarboxylate mutase: subunit: gltB peroxidase: diphosphatase: ppa KAB01_RS08020 monooxygenase: DNA a nucleoside 5'- anhydrase: adenosyltransferase: KAB01_RS09005 phosphate quinolinate kinase primary-amine thiouridine(34) pyruvate disulfide-bond phosphogluconate CoA reductase: 2-C-methyl-D-synthase: ispG ala oxythiamine pyrimidinemethanol thiaminase II: tenA pantetheine- KAB01_RS01385 glu asn KAB01_RS08955 [+ 2 isozymes] KAB01_RS14210 monophosphate KAB01_RS17555 RS12200 KAB01_RS15995 a [bis(guanylyl pyridoxine 5'- synthase AroK: aroK oxidase: tynA synthase oxidoreductase: aldolase: eda KAB01_RS10785 erythritol-2,4- thiamine- phosphate 2-phenylethylamine 2'-(5''-triphospho- phosphoenolpyruvate a (2E)-2- [+ 2 isozymes] an L-seryl- adenosylcob(III) molybdopterin) hydroxymethylpyrimidine/ phosphate NadA: nadA shikimate 3- phenylacetaldehyde MnmA: mnmA : yghU IDP cyclodiphosphate RS09220 thiaminase phosphate adenylyltransferase: 2-phospho- 3-[(4-amino-6-chloro- H + α-D-ribosyl)-3'- enoyl-CoA [tRNA sec ] RS17830 RS11140 alamin-[corrinoid cofactor [bis-MGD cofactor phosphomethylpyrimidine 6-(2-amino-2-carboxyethyl) 4-amino-2-methyl-5- 5-(2-hydroxyethyl)-4-methylthiazole synthase: pdxJ phosphate protein S-nitrosylation KAB01_RS02335 2,2'-disulfonyl phosphate adenine kinase: thiL coaD D-glycerate 34 1,3,5-triazin-2-yl) phthalate CO H O acetaldehyde nitrite 2-methyladeninyl adenosylcobamide adenosyltranferase] chaperone]-S- chaperone]- II: tenA kinase: KAB01_RS04150 -7,8-dioxo-1,2,3,4,7,8- pyrimidinemethanol quinolinate a 2-thiouridine azobenzene dephospho-CoA 2 2 bifunctional prephenate and denitrosylation asp amino]benzenesulfonate a protein with glyoxylate pyruvate CO H O hexahydroquinoline hydroxymethylpyrimidine/ thiamine 3'-dephospho- in tRNA 2 2 Ffh biosynthesis from adenosylcobinamide-GDP cob(I)yrinic acid sulfanyl-L-cysteine bis-MGD 5-(2-hydroxyethyl) HMP-P hydroxyethylthiazole carboxylating Fatty Acid and Lipid Degradation GSSG reduced L- 2,4-dicarboxylate phosphomethylpyrimidine pyridoxine 5'-phosphate diphosphate CoA dehydrogenase/3- phosphopyruvate tRNA uridine-5- a [protein]- a,c-diamide -4-methylthiazole kinase: thiM nicotinate- cysteine residues 2-methyladenine pyrroloquinoline- kinase: KAB01_RS04150 dephospho- phosphoshikimate 1- 2-phenylethanol hydratase: eno carboxymethylaminomethyl(34) L-cysteine RS09175 RS10095 RS02535 adenosyltransferase: hydroxyethylthiazole hydroxymethylpyrimidine/ pyridoxamine nucleotide β quinone synthase 4-methyl-5-(2- CoA kinase: carboxyvinyltransferase: synthesis GTPase MnmE: mnmE oleate -oxidation KAB01_RS15995 kinase: thiM phosphomethylpyrimidine 5'-phosphate diphosphorylase: fatty acid β-oxidation I (generic) nicotinate-nucleotide-- sulfo-bis(guanylyl PqqC: pqqC HMP-P phosphooxyethyl)thiazole KAB01_RS01845 KAB01_RS12975 a purine base N-acetyl-muramoyl-(L- DNA with adenine:7,8- α ε a triacyl-sn a (2E,4E)-2,4- an S-(1-hydroxy- 4-methyl-3- 4-methyl-5-(2- kinase: KAB01_RS04150 oxidase: pdxH KAB01_RS00375 5-enolpyruvoyl- phosphoenol tRNA uridine-5- 3-aci- a peptide with a N ,N -diacetyl-lysyl- L-cysteate urea-1-carboxylate RS03965 dimethylbenzimidazole adenosylcobalamin molybdopterin) thiamine phosphate lesion in DNA alanyl-γ-D-glutamyl-L- dihydro-8- -glycerol dienoyl-CoA 2-oxopropyl) oxoadipate- phosphooxyethyl) hydroxymethylpyrimidine/ coenzyme A shikimate 3- pyruvate carboxymethylaminomethyl(34) a [protein] 3- oleate dGTP nitropropanoate ATP leader sequence D-alanyl-D-alanine phosphoribosyltransferase: cofactor HMP-PP pyrroloquinoline quinone synthase: adeninyl adenosylcobamide biosynthesis a (3Z)-alk-3-enoyl-CoA a tRNA precursor lysyl-D-alanyl-D-alanine) oxoguanine mismatch NADPH-dependent aspartate/ -[protein]- enol-lactone thiazole phosphomethylpyrimidine PLP NaMN phosphate synthesis enzyme MnmG: mnmG nitrosothio- CTP 3-oxoadipate RS09115 RS00335 RS07015 cobT KAB01_RS13025 from adenosylcobinamide-GDP long-chain-fatty- 2,4-dienoyl- tyrosine/aromatic L-cysteine folate transformations III (E. coli) kinase: KAB01_RS04150 chorismate phosphoenolpyruvate a 5-carboxymethylaminomethyl- L-alanine bifunctional DNA- nitronate D-alanyl- triacylglycerol allophanate enol- thiamine phosphate nicotinate-nicotinamide acid--CoA ligase: ∆ 3 -cis-∆ 2 -trans- CoA reductase: aminotransferase: molybdopterin biosynthesis 34 D-alanyl- signal A/G-specific lipase: hydrolase: lactonase: thiamine synthase: synthase: ppsA 2-thiouridine in tRNA KAB01_RS01125 formamidopyrimidine deoxyguanosinetriphosphate monooxygenase: D-alanine KAB01_RS06365 KAB01_RS00525 RS03920 2-methyladenine HMP-PP synthase: nucleotide enoyl-CoA multifunctional D-alanine peptidase I: lepB adenine KAB01_RS17200 atzF pcaD a tetrahydrofolate phosphate adenine aroC glycosylase/ triphosphohydrolase: KAB01_RS07650 endopeptidase adenosylcobinamide- ribotide phosphate benzimidazolyl adenosylcobamide KAB01_RS14060 adenylyltransferase: [+ 3 isozymes] isomerase: CCA addition/ endopeptidase signal glycosylase: NADPH-dependent bifunctional synthase: cys DNA-(apurinic KAB01_RS14495 nitronate PBP7/8: pbpG 3-oxoadipate RS09055 RS13110 RS07065 GDP biosynthesis from adenosylcobinamide-GDP KAB01_RS14465 chorismate pyruvate a [protein]- fadB repair protein: PBP7/8: pbpG peptidase I: lepB mutY 2,4-dienoyl- aspartate KAB01_RS13025 nicotinate-nucleotide-- S-nitrosoglutathione oleoyl-CoA or apyrimidinic monooxygenase: [+ 3 isozymes] a diacyl-sn enol- dihydrofolate reductase: methionine thiamine phosphate nicotinate adenine a 5-aminomethyl-2- L-cysteine KAB01_RS13310 [+ 3 isozymes] a fatty acid CoA reductase: transaminase/ ammonium CO thiamine dimethylbenzimidazole cysteine 3-hydroxyacyl- site) lyase: mutM KAB01_RS14210 -glycerol 2 lactonase: RS16640 adenosylcobinamide- synthase: metH dinucleotide ATP thiouridine 34 in tRNA a (2E)-2-enoyl-CoA KAB01_RS10785 aspartate 4- KAB01_RS02500 phosphate benzimidazole desulfurase: S-(hydroxymethyl) acyl-CoA enoyl-CoA CoA an apurinic site (R)-lactate a [protein]- pcaD GDP : dipyrromethane phosphoribosyltransferase: triphosphate a tRNA Nα,Nε-diacetyl- a (2E)-2- decarboxylase: 4-methyl-3- dihydrofolate reductase: synthase: NAD+ synthase: NAD+ synthase: KAB01_RS07940 5-methylaminomethyl- glutathione dehydrogenase: hydratase: epimerase: a [DNA]- 2'-deoxyguanosine N-acetyl-muramoyl-(L- a leader sequence a peptide adenine within DNA L-cysteine ribazoletransferase: KAB01_RS03630 nicotinate-nucleotide-- cofactor biosynthesis cobT a 2,3,4-saturated long-chain-fatty- acyl-CoA a 2,3,4-saturated (3R a 5'-phospho- a modified [unspecified containing a lysyl-D-alanine D-ala enoyl-CoA KAB01_RS12615 oxoadipate RS08905 RS13145 RS07190 KAB01_RS10350 KAB01_RS14060 KAB01_RS04335 KAB01_RS04335 GTP 2-thiouridine-forming dehydrogenase/ KAB01_RS13680 KAB01_RS00670 fadB nucleotide- 4-oxo-2-pentenal 3-oxopropanoate nitrite alanyl-γ-D-glutamyl- D-ala KAB01_RS09160 dimethylbenzimidazole IscS subfamily ATP biosynthesis fatty acid acid--CoA ligase: dehydrogenase: )-3-hydroxyacyl-CoA [DNA] nucleobase degradation 3' CCA end serine an apo-[hydroxymethylbilane adenine ribotide methyltransferase: class III alcohol [+ 5 isozymes] 3'-phosphate L-lysyl-D-alanine) 3-sulfopyruvate phosphoribosyltransferase: thiamine + cysteine products] RS16565 α α synthase]-L-cysteine adenosylcobinamide- phosphate NAD KAB01_RS16230 dehydrogenase: (2E,9Z)- KAB01_RS01125KAB01_RS00715 Co -[ -(2- a 7,8-dihydrofolate hydroxymethyltransferase:a 5-methyltetrahydrofolate thiamine cobT desulfurase: a carboxy- GTP 3',8- Carboxylate Degradation GDP ADP KAB01_RS09765 octadecenoyl-CoA [+ 3 isozymes] [+ 5 isozymes]a 2,3,4-saturated a 2,3,4-saturated (3S methyladenin-9-yl)]-Co KAB01_RS13135 phosphate benzimidazole KAB01_RS09005 adenylated cyclase a 5-methylaminomethyl- β F0F1 ATP synthase: 2-thiouridine 34 in tRNA fatty acyl CoA )-3-hydroxyacyl-CoA a [ribosomal a 1-acyl-2- 2445 (2S)- a peptide with 6-O-trans- RS08865 RS13445 RS14955 -adenosylcobamide adenosylcobinamide- ribotide a [hydroxymethylbilane an [L-cysteine [small subunit of MoaA: S-(hydroxysulfenamide) enoyl-CoA 2-methylcitrate cycle II + a guanine a nucleoside a supercoiled thymidylate a (6S)-5-formyltetrahydrofolate KAB01_RS00885 atpB a sulfurated a ferrocytochrome palmitoyl-CoA 2,3- a holo-[DhbB aryl- a (6S)-5- menadione NADH H methylsuccinyl- a uracil in DNA chloramphenicol 5'-phosphate bifunctional GDP phosphate synthase] ES intermediate adenosylcobinamide- desulfurase]-S- molybdopterin moaA glutathione hydratase: 3-hydroxyacyl-CoA L-ascorbate pyruvate fermentation to acetate IV protein S12] glu arachidonoyl- in 23S rRNA acetyl-CoA triphosphate RNA an N-terminal methoxy-mycolyl- duplex DNA synthase: thyA 2 [sulfur carrier] 89 b carrier protein] formyltetrahydrofolate RS03795 methylenetetrahydrofolate thiamine diphosphate GDP synthase] (8S)-3',8-cyclo-7,8- atpE KAB01_RS00900 KAB01_RS00670 degradation V L-aspartate 5 dihydroxybenzoate sn-glycerol bifunctional CoA CatB-related O- L-alanine trehalose 6- ATP- 5-formyltetrahydrofolate 5-methylbenzimidazolyl adenosylcobamide hydroxymethylbilane sulfanyl-L-cysteine dehydrogenase: biotin biosynthesis from dehydrogenase/ ribazoletransferase: NAD salvage pathway V (PNC V cycle) dihydroguanosine KAB01_RS00905 propanoate 3-phosphate CTP 23S rRNA acetyltransferase: phosphate dependent cyclo-ligase: adenosylcobinamide- biosynthesis from adenosylcobinamide-GDP synthase: hemC a 5-methylaminomethyl- (S)-3-hydroxy-(9Z) coenzyme A KAB01_RS07435 pyruvate NADH-quinone uracil-DNA trehalose- 8-amino-7-oxononanoate I methylenetetrahydrofolate methenyltetrahydrofolate di-trans,poly-cis KAB01_RS09160 5'-triphosphate KAB01_RS00910 atpG L-ascorbate acyl-CoA bifunctional (guanine(2069)-N(7) 3-oxoadipyl- KAB01_RS15020 DNA- DNA Coα-[α-(2- KAB01_RS05830 GDP 2-(S-geranyl) -octadecenoyl-CoA a 2,3,4-saturated a 2,3,4-saturated long-chain-fatty- 30S ribosomal (2,3- oxidoreductase: glycosylase: aminopeptidase phosphatase: RS08820 RS06280 reductase [NAD(P)H]: metF cyclohydrolase FolD: folD -undecaprenyl a [hydroxymethylbilane NAD + atpD KAB01_RS00925 desaturase: tetrahydrofolate phosphatidate )-methyltransferase CoA chloramphenicol directed RNA helicase methyladenin-7-yl)]-Co (8S)-8-amino-7- ribazoletransferase: 5-methylbenzimidazole α α NAD-dependent thiouridine 34 in tRNA hydroxylamine 3-hydroxyacyl-CoA acetyl-CoA C- acid--CoA ligase: protein S12 dihydroxybenzoyl) nuoC nuoE nuoF ung N: pepN otsB RS08610 a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate phosphate biosynthesis synthase] ES intermediate Co -[ -(adenin-9-yl)]- a thiocarboxylated fatty acyl CoA 3-oxoacyl-CoA KAB01_RS16010 synthase/ cytidylyltransferase: RlmK/23S rRNA : acetyltransferase polymerase: trehalose- RecG: recG β-adenosylcobamide oxononanoate KAB01_RS09160 3 β deacylase: ATP dehydrogenase: acyltransferase KAB01_RS10425 methylthiotransferase adenylate nuoG nuoH adenosylmethionine- (2E,6E)-farnesyl nicotinate-nucleotide-- Co -adenosylcobamide (guanine(2445)-N(2) rpoB rpoC trans-methoxy- IPP hydroxymethylbilane NAD+ synthase: KAB01_RS08590 [small subunit of cyclic KAB01_RS07435 FadA: fadA [+ 3 isozymes] dehydroascorbate RimO: rimO [+ 2 isozymes] synthase: entE dihydrofolate nuoI nuoJ nuoK KAB01_RS11180 pcaF CAT: DNA -8-amino-7- bifunctional diphosphate Coα-[α- dimethylbenzimidazole 5'-phosphate molybdopterin pyranopterin synthase: folC )-methyltransferase an apyrimidinic uracil KAB01_RS06905 [+ 4 isozymes] mono-mycolate helicase synthase: hemC KAB01_RS04335 S-adenosyl-L- 3-oxo-(9Z)- superpathway of acetate nuoM nuoN [+ 3 isozymes] oxononanoate methylenetetrahydrofolate (benzimidazolyl)]-Co phosphoribosyltransferase: synthase] phosphate a 5-methylaminomethyl- acetyl-CoA formate RlmL: rlmKL site in DNA chloramphenicol ala a peptide Rep: rep RS03895 RS01425 methionine salvage II propanoyl-CoA utilization and formation a [ribosomal a 2,3- a CDP-1-acyl- an N 2 - transaminase: bioA dehydrogenase/ β cobT a [hydroxymethylbilane 2-(Se-phospho) octadecenoyl-CoA 3-acetate a single RS16340 di-trans,poly-cis- -adenosylcobamide ammonium 5'-deoxyadenosine an unsulfurated palmitoleoyl-CoA a ferricytochrome 2-arachidonoyl- 2445 glutathione (7R,8S)-diaminononanoate molybdenum NAD salvage methenyltetrahydrofolate synthase] ES intermediate nicotinate adenine nicotinamide selenouridine 34 in tRNA acetyl-CoA C- phosphate met protein S12]-3- dihydroxybenzoyl- a (6S)-5- methylguanine 4-methyl-3- stranded DNA decaprenylcistransferase: 5'-phosphate 4 α α 2-methylcitrate acetate [sulfur carrier] b + RNA adenosylcobinamide- 5-methylbenzimidazole Co -[ -(adenin-7-yl)]- dinucleotide SAH 2,3-didehydro- methylsulfanyl- 5 [DhbB aryl- NAD menadiol glycerol in 23S rRNA biosynthesis cofactor biosynthesis pathway III (to cyclohydrolase FolD: folD bifunctional acyltransferase acetyltransferase: pta acetate--CoA formyltetrahydrofolate oxoadipyl-CoA uppS ribotide phosphate hydroxymethylbilane Coβ-adenosylcobamide tRNA processing acetyl-CoA synthase: prpC 89 ATP-dependent nicotinamide riboside) GDP adenosylhomocysteinase: FadA: fadA L-gulonate ligase: acs L-aspartate carrier protein] 10 synthase: hemC nicotinamidase/ acetate kinase: RS06390 dethiobiotin molybdate an N -formyltetrahydrofolate nicotinate-nicotinamide molybdopterin (2S,3S)-2- acetyl phosphate RS16560 cys glu + di-trans,octa-cis pyrazinamidase: KAB01_RS13285 a 5-methylaminomethyl- RS03600 synthetase NADP Coα-[α- adenosylcobinamide- cytidylyl molybdenum a holo-[hydroxymethylbilane nucleotide a polycistronic (7Z)-hexadecenoyl-CoA phospholipases methylcitrate KAB01_RS02630 -undecaprenyl 34 34 2069 a peptidoglycan D-sedoheptulose predicted (benzimidazolyl)]-Co cofactor sulfurylation synthase] adenylyltransferase: pncA L-homocysteine 2-selenouridine tRNA precursor a 5,10- a 2-thiouridine a holo-[EntB aryl- a [protein] N-terminal- a guanine (S)-1-pyrroline- BioD: bioD molybdopterin diphosphate GDP Fe/S-dependent acetate kinase: ala a pimeloyl-[acp] 2,3- acetoacetate succinyl-CoA SAH dimer (S. aureus) a folate 1-phosphate a protein a protein ABC β-adenosylcobamide KAB01_RS14465 in tRNA acyl-CoA phospholipase D: 2-carboxy-L- acetyl phosphate acetyl-CoA methylenetetrahydrofolate in tRNA carrier protein] formyl-L-methionine in 23S rRNA 5-carboxylate dGDP glutamate-- undecaprenyl- ribazoletransferase: cytidylyl molybdenum NaMN nicotinate methionine synthase: metH a 1,2-diacyl- 2-methylisocitrate KAB01_RS02630 dihydroxybenzoate bifunctional dihydrofolate trifunctional dethiobiotin transporter + Carbohydrate Biosynthesis dehydrogenase: KAB01_RS16070 lyxonolactone ATP-dependent cysteine ligase: NAD diphosphatase: KAB01_RS09160 cofactor (trioxo) methionine synthase: a phosphatidylcholine sn-glycerol dehydratase 23S rRNA reductase: transcriptional ribonucleotide- RS19260 TolB of molybdate: KAB01_RS13680 D-alanyl- fructose- Clp protease metalloprotease: RS08445 KAB01_RS18315 menaquinol-7 biosynthesis KAB01_RS00120 KAB01_RS03630 menaquinol-9 biosynthesis 3-phosphate AcnD: acnD acetate tRNA uridine-5- 3-oxoacid CoA- peptide (guanine(2069)-N(7) KAB01_RS02500 regulator/proline diphosphate biotin synthase modA modB NAD(+) Coα-[α-(5- folate polyglutamylation gluconeogenesis I [+ 5 isozymes] phosphate carboxymethylaminomethyl(34) 8-amino-7- (2,3- 5'-methylthioadenosine/ deformylase: D-alanine bisphosphate ATP-binding KAB01_RS15035 reductase: molybdopterin an [MCD cofactor PRPP biosynthesis α a tRNA precursor a tRNA precursor 2-methyl-trans )-methyltransferase dihydrofolate dehydrogenase/L- BioB: bioB diphosphatase: all-trans- undecaprenyl- NAD methylbenzimidazolyl)]- nicotinate CMP-pseudaminate biosynthesis UDP- -D- (2E,7Z)- acetyltransferase: pta synthesis GTPase MnmE: mnmE oxononanoate dihydroxybenzoyl) subunit A: S-adenosylhomocysteine KAB01_RS00975 endopeptidase aldolase class II: subunit ClpA: clpA KAB01_RS03760 γ-L-glutamyl- molybdate adenine 1,4-dihydroxy- thiamine chaperone]-MCD met lipoate biosynthesis with a 5' with a 5' a 1-acyl-sn -aconitate 2-carboxy- RlmK/23S rRNA reductase: glutamate gamma- nudC heptaprenyl diphosphate phosphorylation and Coβ-adenosylcobamide phosphoribosyltransferase: demethylmenaquinol-9 galactose hexadecenoyl-CoA synthase: adenylate KAB01_RS10725 nucleosidase: PBP7/8: pbpG KAB01_RS08675 ATP-dependent a peptide KAB01_RS03770 L-cysteine 9-mercaptodethiobiotin dinucleotide 2-naphthoate diphosphate a tetrahydrofolate and incorporation I (S)-malate D-ribose 5- α extension and extension and a a phosphatidylcholine -glycero-3- L-lyxonate tRNA uridine-5- peptide (guanine(2445)-N(2) KAB01_RS10350 semialdehyde RS02005 diphosphate phosphatase: transhydrogenation 5'-phosphate cysteine KAB01_RS10060 bifunctional UDP-N-acetyl- -D-glucosamine biosynthesis enoyl-CoA 2-methylaconitate KAB01_RS04080 synthase: entE KAB01_RS03955 [+ 3 isozymes] Clp: clpP clpX RS03695 RS11875 glutathione NMN salvage I methionine phosphate UDP-N-acetylglucosamine a long 3' trailer short 3' extension phosphocholine carboxymethylaminomethyl(34) [+ 2 isozymes] deformylase: def )-methyltransferase dehydrogenase: GDP KAB01_RS15410 desulfurase: nicotinate demethylmenaquinone ribose-phosphate UDP-α-D-glucose hydratase: cis-trans a 7,8-dihydrofolate a peptide synthase: biotin synthase molybdopterin di-trans,octa-cis NAD + adenosyltransferase: an octanoyl-[acp] 4,6-dehydratase ribonuclease synthesis enzyme MnmG: mnmG RlmL: rlmKL putA thiamine KAB01_RS07940 serine methyltransferase/2- pyrophosphokinase: UDP-glucose isomerase pyruvate decarboxylation to acetyl CoA I D-gluconate a 2,3- 7 DHAP D-erythrose BioB: bioB molybdotransferase bifunctional -undecaprenyl NAD(+)/ bifunctional phosphoribosyltransferase: KAB01_RS08530 lipoyl(octanoyl) P protein KAB01_RS00670 a 2-acyl-sn (8S)-8-amino-7- S-ribosyl-L- an N - a peptidoglycan gshB methoxy-6-polyprenyl- (inverting): pseB PrpF: prpF an N-terminal L- 2069 MoeA: metallophosphatase/ Coα-[α-(5- IscS subfamily hydroxymethyltransferase: tetrahydrofolate pncB KAB01_RS04190 UDP-2-acetamido-2,6-dideoxy- 4-epimerase component: (S)-3-hydroxy-(7Z) a phosphatidylcholine -glycero-3- degradation oxononanoate acyl-carrier protein dihydroxybenzoyl- acetoacetyl-CoA succinate adenine formate methylguanine with D,D cross- D-ala glu phosphate NADH kinase: transferase 1,4-benzoquinol malate L-lyxonate a [pyruvate a 5-aminomethyl-2- homocysteine methionyl-[protein] biotin KAB01_RS11305 5'-nucleotidase: cysteine KAB01_RS13135 synthase/ 10 SAM ribose-phosphate β GalE: galE ribonuclease rnpA phosphocholine cis-2- a 7,8-dihydrofolate [EntB aryl- in 23S rRNA link (S. aureus) RS07225 glutathione demethylmenaquinol-7 KAB01_RS14905 methylbenzimidazolyl)]- an N - LipB: lipB dehydrogenase: -L-arabino-hex-4-ulose -hexadecenoyl-CoA 34 RS11965 RS03275 thiamine desulfurase: a [lipoyl-carrier protein] methylase UbiE: ubiE malate UDP-α-D-galactose PH: rph methylaconitate dehydrogenase pyruvate D-gluconate thiouridine in tRNA carrier protein] KAB01_RS09690 Coβ-adenosylcobamide dihydrofolate formyltetrahydrofolate pyrophosphokinase: UDP-4-amino-4, 6-dideoxy- a tRNA precursor 6 phosphate 6 KAB01_RS16505 3-hydroxyacyl-CoA E2 protein] N MoO - 1-(β-D bifunctional NAD(+) kinase: KAB01_RS09005 a 5,10- synthase: folC N -octanoyl-L- menaquinol-9 dehydrogenase: KAB01_RS10065 polyribonucleotide with a short Fe/S-dependent pyruvate gluconokinase: 2 bifunctional N-acetyl-beta-L-altrosamine dehydrogenase: phospholipase C, -lipoyl-L-lysine molybdopterin ribofuranosyl) demethylmenaquinone KAB01_RS13010 thiamine- a [cytidylyl molybdenum methylenetetrahydrofolate tetrahydropteridine recycling lipoyl KAB01_RS13305 PRPP nucleotidyltransferase: pnp3' extension 2-methylisocitrate dehydrogenase KAB01_RS02660 + tetrahydrofolate transaminase: pseC KAB01_RS07435 phosphocholine- D-gluconate UDP-N-acetyl-α-D-muramoyl- D-sedoheptulose an insertion 6-O-cis-methoxy- NADP 7,8-dihydrofolate + an N-modified (R)-S- cofactor nicotinamide methyltransferase/2- menaquinol-8 biosynthesis phosphate cofactor chaperone]- bifunctional synthase: lipA UDP-4-amino-4,6-dideoxy- a tRNA dehydratase dihydrolipoyl (acetyl- di-trans,octa-cis- γ cob(II)inamide NADPH H a 3-oxoacid succinyl-CoA 5'-deoxyadenosine an alkylated DNA H O sequence RNA mycolyl-trehalose acetyl-CoA a tetrahydrofolate synthase/ pyruvate 3-oxo-(7Z)- specific: 6-phosphate L-alanyl- -D-glutamyl-L- monoglutamate 2 lactoylglutathione 1,7-bisphosphate RS03585 RS19000 base-degraded menaquinol-6 biosynthesis methoxy-6-polyprenyl- kinase: thiL cytidylyl molybdenum lipoyl β precursor with AcnD: acnD dehydrogenase: transferring), undecaprenyl phosphate ATP aminoacyl-[tRNA] GTP RS06660 NAD(P) NADP tetrahydrofolate dihydrofolate a 4a-hydroxytetrahydropteridine oxaloacetate N-acetyl- -L-altrosamine hexadecenoyl-CoA KAB01_RS00365 a 1,2-diacyl- lysyl-D-alanyl-D-alanine element IS30DDE-type 6-phosphate acetyl-CoA RS16075 thiamine salvage 1,4-benzoquinol thiamine cofactor (sulfo-dioxo) synthase: lipA a 5' extension ribonuclease a phosphatidylcholine KAB01_RS16275 homodimeric trehalose- demethylmenaquinol-8 transhydrogenase biosynthesis synthase/ synthase: folC UDP-4-amino-4, 6-dideoxy- sn-glycerol bifunctional integrase/ carboxylase methylase UbiE: ubiE diphosphate a [lipoyl-carrier phosphoenolpyruvate PH: rph acetyl-CoA C- type: aceE dihydrofolate 3-oxoacid CoA- 5'-methylthioadenosine/ DNA-3- fructose- phosphatase: formylaminopyrimidine demethylmenaquinol-6 bifunctional subunit alpha: dihydrofolate 10 N-acetyl-beta-L-altrosamine aconitate [+ 2 isozymes] phospho-N- lactoylglutathione ribonuclease biotin carboxyl an N - 6 acyltransferase aminoacyl- transposase/ + protein]-N -[(R)- ribonuclease cob(I)yrinic acid reductase: transferase: S-adenosylhomocysteine methyladenine GTPase bisphosphate otsB bifunctional demethylmenaquinone KAB01_RS03030 NAD synthase: folC synthase: ppsA N-acetyltransferase: pseH hydratase 2/2- acetylmuramoyl- tRNA lyase: gloA PH: rph trehalose- carrier RS15885 menaquinol-7 formyltetrahydrofolate a 6,7-dihydropteridine dihydrolipoyl]-L-lysine P protein FadA: fadA a 1-phosphatidyl- a [pyruvate a [pyruvate a,c-diamide KAB01_RS10350 KAB01_RS07695 nucleosidase: glycosylase: Era: era aldolase class II: recombinase: demethylmenaquinone methyltransferase/2- NAD(+)/ a 5,10- UDP-2,4-diacetamido-2,4,6- a 1,2-diacyl- methylisocitrate pentapeptide- hydrolase: cis-methoxy- protein: accB RS08425 aminomethylpyrimidine NADPH component: 1D-myo-inositol dehydrogenase dehydrogenase adenosyltransferase: KAB01_RS07700 KAB01_RS03955 KAB01_RS15765 [+ 4 isozymes] KAB01_RS08675 KAB01_RS01185 methyltransferase/2- methoxy-6-polyprenyl- NADH kinase: oxygen-insensitive trideoxy-β-L-altropyranose sn-glycerol dehydratase: 6 6 dihydrofolate RS09780 methylenetetrahydrofolate phosphoenolpyruvate (5Z)-tetradecenoyl-CoA 4,5-bisphosphate E2 protein] N E2 protein] N -S- transferase: KAB01_RS15995 pth [+ 2 isozymes] mono-mycolate [+ 3 isozymes] RS06590 rnpA 6 37 reductase: [+ 2 isozymes] an insertion thiaminase methoxy-6-polyprenyl- 1,4-benzoquinol KAB01_RS14905 NAD(P)H UDP-2,4-diacetamido- N -L-threonylcarbamoyladenosine KAB01_RS12210 -dihydrolipoyl- acetyldihydrolipoyl- KAB01_RS17405 glutathione methylglyoxal a nucleoside RNA malonyl-CoA a DNA containing + sequence IS30 II: tenA 1,4-benzoquinol methylase UbiE: ubiE NAD(+) kinase: nitroreductase: nfsB phosphopyruvate 2,4, 6-trideoxy-beta- -modified tRNA biosynthesis acyl-CoA lipoate KAB01_RS02500 an alkylated phosphate H D-erythrose diphosphate (2R,3S)-2- L-lysine L-lysine adenosylcobinamide 5-deoxy-D-ribose an apurinic/ GDP DHAP with integrated RS08100 methylase UbiE: ubiE menaquinol-8 KAB01_RS13010 hydratase: eno UDP-N-acetyl-D- L-altropyranose dehydrogenase: acetyltransferase: a 2,3,4-saturated adenine nucleobase an N-modified an uncharged 4-phosphate 4-amino-2-methyl-5- a 5,6,7,8-tetrahydropteridine methylisocitrate undecaprenyl-diphospho-N- UMP triphosphate succinate apyrimidinic site transposon RS16095 menaquinol-6 NADP + glucosamine biosynthesis I hydrolase: pseG KAB01_RS00715 aceE γ 3-oxoacyl-CoA amino acid tRNA pyrimidinemethanol thr triacylglycerol acetylmuramoyl-L-alanyl- -D- 5,6,7,8- + 2-phospho-D-glycerate an uncharged [+ 5 isozymes] NADP D-glucopyranose 2,4-diacetamido-2,4,6- threonylcarbamoyl- degradation methylisocitrate glutamyl-L-lysyl- D-alanyl-D-alanine tetrahydrofolate RS14085 β tRNA GspD 6-phosphate trideoxy- -L-altropyranose AMP synthase: (2E,5Z)- lyase: prpB RS03100 2,3-bisphosphoglycerate- glucose-6- tetradecenoyl-CoA a triacyl-sn pseudaminic acid KAB01_RS00960 α independent phosphate -glycerol UDP-N-acetyl- -D- a reduced sn-glycero-3- a peptidoglycan a [protein chain a ribonucleoside succinate 6-O-trans-keto- AmvA synthase: pseI threonylcarbamoyl- triacylglycerol di-trans,octa-cis- cob(II)alamin ubiquinone-6 O-succinyl-L- 1-butanesulfonate tributyrin a phenyl acetate Secondary Metabolite Biosynthesis phosphoglycerate isomerase: pgi ∆ 3 ∆ 2 pyruvate succinate acetyl-CoA muramoyl-L-alanyl-γ-D- electron-transfer phospho-N- dimer (generic) (R)-β-lysine elongation factor semialdehyde mycolyl-trehalose Nucleoside and Nucleotide Biosynthesis -cis- -trans- enoyl-CoA lipase: undecaprenyl phosphate ATP homoserine diphosphate ATP mutase: F6P pseudaminate AMP synthase: glutamyl-L-lysyl-D-alanine flavoprotein (arachidonoyl) P]-L-lysine 34 ribonucleotide- RNA NAD-dependent 6-phosphate lipoprotein posttranslational modification enoyl-CoA hydratase: KAB01_RS17200 trehalose- KAB01_RS01385 (L-threonylcarbamoyl)KAB01_RS04110 a 1,2-diacyl- ethanolamine diphosphate succinate- RS06305 RS03065 methylerythritol phosphate pathway I superpathway of pyrimidine glutamine-- pseudaminic acid isomerase: KAB01_RS00670 endolytic FMNH2-dependent triacylglycerol phosphatase: RS10860 baumannoferrin biosynthesis acinetobactin biosynthesis inosine-5'-phosphate biosynthesis I adenine and adenosine salvage III 5-aminoimidazole ribonucleotide biosynthesis I adenylate sn-glycerol electron transfer O-succinylhomoserine reductase: semialdehyde indole-3-acetate ribonucleotides de novo biosynthesis superpathway of superpathway of fructose-6- cytidylyltransferase: pseF a [prolipoprotein]- fadB phospho-N- cob(I)yrinic acid transglycosylase EF-P lysine alkanesulfonate lipase: otsB RS08200 3-phospho-D-glycerate flavoprotein- sulfhydrylase: KAB01_RS03760 polynucleotide dehydrogenase: D-glyceraldehyde biosynthesis guanosine nucleotides adenosine nucleotides phosphate CMP-pseudaminate L-cysteine tRNA (adenosine(37)-N6)- (S)-3-hydroxy-(5Z) acetylmuramoyl- a,c-diamide glycerophosphodiester MltG: mltG aminoacylase monooxygenase: KAB01_RS17200 trehalose- pyruvate ubiquinone KAB01_RS09285 KAB01_RS03770 adenylyltransferase KAB01_RS17845 3-phosphate L-aspartate 4- IV (bacteria) de novo biosynthesis I de novo biosynthesis I AIR PRPP phosphoglycerate transaminase prolipoprotein threonylcarbamoyltransferase (3E,5Z)-tetradeca- -tetradecenoyl-CoA pentapeptide- adenosyltransferase: phosphodiesterase: [+ 3 isozymes] GenX: genX ssuD a 2'- trans-keto- ATP ATP (indol-3-yl) gln hydrogencarbonate oxidoreductase: PcnB: pcnB [+ 2 isozymes] semialdehyde thr adenine kinase: α diacylglyceryl complex dimerization 3,5-dienoyl-CoA 3-hydroxyacyl-CoA transferase: KAB01_RS15995 KAB01_RS16000 deoxyribonucleoside mono-mycolate RS03020 2,3-dihydroxybenzoate 5-(carboxyamino)imidazole (isomerizing) UDP- -D-glucose KAB01_RS02090 1-deoxy-D- acetonitrile IMP IMP pyrimidine/purine KAB01_RS08665 transferase: subunit type 1 TsaB: tsaB acyl-CoA dehydrogenase: a 2-acylglycerol KAB01_RS17405 [a protein chain 5'-diphosphate butanoate 1,2-dibutyrin succinate acetate a phenol RS01145 diaminobutyrate- asp ribonucleotide synthase: amidophosphoribosyltransferase: purF : glmS biosynthesis GlcNAc-1,6- RS08160 RS13885 xylulose-5- nucleoside phosphorylase: KAB01_RS02520 thioesterase: KAB01_RS07435 L-homocysteine succinate a lipid II elongation factor 1-butanal sulfite -2-oxoglutarate glutamine- KAB01_RS00145 D-glucosamine tRNA (adenosine(37)-N6)- adenosylcobalamin an oxidized sn-glycerol anhydro-MurNAc- RNA phosphate (2,3-dihydroxybenzoyl) (indol-3-yl) KAB01_RS01830 13-DPG D-glucopyranose a [prolipoprotein]- undecaprenyl-diphospho-N triphosphate + anandamide β transaminase: hydrolyzing IMP 5-phospho-β- gly 6-phosphate CMP-3-deoxy-D- threonylcarbamoyltransferase KAB01_RS14360 3-oxo-(5Z)- UMP electron-transfer H ubiquinol-6 3-phosphate pentapeptide EF-P]-N-( -L- synthase: dxs adenylate synthase: entE adenosine 6-phosphate -acetylmuramoyl-L-alanyl-γ- 34 KAB01_RS14000 acetamide carbamoyl- dehydrogenase: adenylosuccinate N5-CAIR D-ribosylamine manno-octulosonate phosphomannomutase/ S-1,2-diacyl-sn- complex ATPase subunit [+ 6 isozymes] tetradecenoyl-CoA lysyl)-L-lysine RS03010 type I phosphoglucosamine D-glutamyl-L-lysyl- D-alanine flavoprotein indoleacetamide phosphate guaB synthase: biosynthesis phosphoglucomutase: glyceryl-L-cysteine type 1 TsaE: tsaE (3E,5Z)- acetyl-CoA C- glycerol 1-deoxy-D-xylulose : add glyceraldehyde- mutase: glmM D-ribulose 6 RS15910 L-2,4-diaminobutanoate (2,3-dihydroxybenzoyl)adenylate (L-threonyl)adenylate hydrolase: iaaH synthase: KAB01_RS06505 5-(carboxyamino)imidazole phosphoribosylamine- KAB01_RS04485 an N -L- tetradecadienoate acyltransferase RS00735 5-phosphate adenosine deaminase: 3-phosphate α-D-glucosamine 5-phosphate signal threonylcarbamoyladenine 37 RS10610 amidase: carA carB XMP ribonucleotide mutase: purE -glycine ligase: purD phosphomannomutase/ FadA: fadA a nascent peptidoglycan quinoxaline-2- an (R)-2- a 1-acyl-2- guanosine 2251 KAB01_RS06460 dehydrogenase: peptidase a ferrocytochrome stearoyl-CoA an adenosine 37 carbamoyl γ coniferaldehyde pyrazinamide phenyl acetate 1-deoxy-D-xylulose- diaminobutyrate (2,3-dihydroxybenzoyl) KAB01_RS10595 1-phosphate phosphoglucomutase: in tRNA (meso-DAP containing) aryl-carrier protein DMAPP L-ornithine arachidonoyl- -L-glutamyl-(S)- gly RS02940 adenylo-succinate asp gap II: lspA (3Z)-dodec- carboxyl adenylate b halocarboxylate in tRNA phosphate in 23S rRNA IMP GTP 5-phosphate decarboxylase: adenylate synthase: entE glutamine- CAIR bifunctional UDP-N- aldehydo-D- 5 phosphatidylcholine 2-aminobutanoate 23S rRNA coniferyl aldehyde bifunctional carbamoyl GAR α KAB01_RS00500 3-enoyl-CoA reductoisomerase: (indol-3-yl)acetate asp inosine glyceraldehyde- arabinose 5- -D-glucopyranose dimethyl sulfide Inorganic Nutrient Metabolism (guanosine(2251) dehydrogenase: 5'/3'-nucleotidase nicotinamidase/ KAB01_RS13995 phosphate hydrolyzing GMP adenylosuccinate acetylglucosamine an (S-diacyl-sn- ∆3,∆2- selenate reduction assimilatory two-component alkanesulfonate monooxygenase endolytic diguanylate RS03160 KAB01_RS11175 a 2,3-dihydroxybenzoyl- 3-phosphate phosphate 1-phosphate a lipoprotein degradation HAD family -2'-O)- KAB01_RS02460 SurE: surE pyrazinamidase: an L-threonyl-[L-threonyl-carrier protein] synthase: guaA lyase: purB phosphoribosylaminoimidazolesuccinocarboxamide phosphoribosylglycinamide diphosphorylase/ glyceryl)-L-cysteinyl- enoyl-CoA sulfate reduction IV transglycosylase acyl carrier protein: acyl-CoA tRNA (adenosine(37)-N6) ornithine glutathione cyclase: propane-1,3-diamine [aryl-carrier protein] pyrimidine/purine triose-phosphate dehydrogenase: UTP--glucose- signal peptide II (oxidation) hydrolase: phospholipase D: methyltransferase bifunctional pncA RS05650 synthase: purC formyltransferase: glucosamine-1- [apolipoprotein] isomerase: an alkylsulfonate FMNH MltG: mltG KAB01_RS00720 desaturase: -dimethylallyltransferase carbamoyltransferase: synthase: coniferyl aldehyde KAB01_RS14275 RS13395 RS07875 MEP aspartate nucleoside phosphorylase: selenate 2 KAB01_RS18470 KAB01_RS16070 GMP KAB01_RS14600 isomerase: KAB01_RS14250 phosphate N- 1-phosphate signal peptide dimethyl sulfide sulfate [+ 3 isozymes] KAB01_RS16010 MiaA: miaA argF gshB RlmB: rlmB dehydrogenase: metallophosphatase/ amidase: carbamoyltransferase: KAB01_RS01830 KAB01_RS01865 uridylyltransferase apolipoprotein N- peptidase fadB sulfate [+ 3 isozymes] [+ 2 isozymes] 2-O- 5'-nucleotidase: c-di-GMP acinetobactin AMP D-glyceraldehyde acetyltransferase D-arabinofuranose sulfate 2251 KAB01_RS10405 KAB01_RS10595 2-C-methyl-D- myo-inositol KAB01_RS06585 SAICAR FGAR DHAP acyltransferase: lnt (2E)-dodec- adenylyltransferase: [+ 2 isozymes] methylguanosine RS08115 non-ribosomal 3-phosphate GlmU: glmU 5-phosphate GalU: galU SppA: sppA 6 a 1-acyl-2- KAB01_RS09690 pyrazine-2- acetate phenol erythritol 4-phosphate biosynthesis guanylate hypoxanthine an N-acyl-(S-diacyl- 2-enoyl-CoA cysD cysN adenylyltransferase: a mature peptidoglycan a nascent peptidoglycan a quinoxaline-2- N -(3-methylbut- in 23S rRNA ferulate N-(3-aminopropyl) peptide synthetase aspartate N-acetyl-α-D- adenosine 5'- an (S)-2- arachidonoyl- choline ophthalmate inosine carboxylate cytidylyltransferase: kinase: gmk adenylate adenylosuccinate phosphoribosylformylglycinamidine 3-deoxy-8- UDP-α-D-glucose sn-glyceryl)-L- dimethyl sulfoxide cysD cysN with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) carboxyl-[aryl- a halide anion 2-en-1-yl)- L-citrulline MacA hydroxylamine subunit BasD: basD D-glucopyranose carbamoyltransferase glucosamine a peptide enoyl-CoA phosphoselenate APS AMP a ferricytochrome hydroxycarboxylate 37 sn-glycerol AdeH KAB01_RS10730 kinase: adk lyase: purB xanthine synthase: purL phosphooctulonate cysteinyl-[lipoprotein] meso-2,6-diaminopimeloyl- with GlcNAc terminus carrier protein] oleoyl-CoA adenosine RS18240 6-phosphate catalytic subunit: 1-phosphate synthase: kdsA hydratase: urea cycle b in tRNA 3-phosphate 4-(cytidine 5'- KAB01_RS06580 phosphoribosyltransferase: fructose- KAB01_RS00670 D-alanine) tetrapeptide 5 GDP bifunctional UDP-N- flavin reductase: YajC diphospho)-2-C- a 2,3-dihydroxybenzoyl-L- ADP AICAR KAB01_RS16550 FGAM bisphosphate FMNH2-dependent acetylglucosamine KDO-8P (S)-3- KAB01_RS03635 methyl-D-erythritol 3 3 threonyl-[L-threonyl-carrier protein] aldolase class II: arg RS02880 N -dec-2-enoyl- N -decanoyl-N Ins(3)P ribonucleotide- bifunctional hypoxanthine hydroxydodecanoyl-CoA dimethyl sulfone alkanesulfonate a peptidoglycan dimer with a [DNA]-3'- a 5'-phospho- a 2'- a peptide with N-acetyl-β-D- an [amino-group carrier a double 4-(cytidine 5'- N-carbamoyl- phosphoribosylformylglycinamidine diphosphorylase/ selenite FMN + an (S)-2- 4-nitrophenyl N 3 -hydroxy-1,3- 3 -hydroxy-1,3- acinetobactin phosphoribosyltransferase: hpt KAB01_RS08675 periplasmic disulfide bond formation PAPS monooxygenase: pentapeptide stems (meso- hydrogen selenide NAD deoxyribonucleoside an N-terminal glucosaminyl-(1 O-ureido-L- protein]-C-terminal-γ- glu ala Ap4A diphospho) histamine L-aspartate ribonucleotide- diphosphate phosphoribosylaminoimidazolecarboxamide cyclo-ligase: purM glucosamine-1- 3-hydroxyacyl-CoA reductase: O-acetyl-L-serine hydroxyl [DNA] halocarboxylate [DNA] asp butanoate stranded DNA dADP diaminopropane diaminopropane non-ribosomal inositol dimethyl sulfone ssuD ammonium diaminopimelate containing) 5'-triphosphate Xaa-L-proline -> 4)-N-acetyl- homoserine (L-glutamyl)-L-glutamate DNA lipid A MsbA lipid A RS00165 -2-C-methyl- diphosphate reductase: formyltransferase/IMP cyclohydrolase: purH phosphate N- a [DsbB protein] a [DsbA protein] two reduced dehydrogenase: msuE symmetrical RS17940 N 3 -dec-2-enoyl- N 3 -decanoyl-N peptide synthetase monophosphatase: : IMP monooxygenase phosphoadenylyl- argininosuccinate β-D-muramate topoisomerase ribonucleotide- D-erythritol putative histamine N- reductase: KAB01_RS03760 AIR acetyltransferase an electron- with reduced L- carrying a cysteine residues KAB01_RS07435 acetylglutamate bis(5'-nucleosyl)- N 3 -hydroxy-1,3- 3 -hydroxy-1,3- subunit BasD: basD KAB01_RS16935 FAICAR β α-Kdo SfnG: sfnG sulfate reductase: lyase: argH glutamine- NAD- HAD family RS02780 monooxygenase: basC pyrC KAB01_RS03770 -D-fructose 1,6- GlmU: glmU transfer quinone 1,6-anhydro-N- cysteine DNA polymerase Xaa-Pro kinase: argB glutamate-- (ATP- tetraphosphatase: diphosphate predicted kinase: ispE diaminopropane- diaminopropane- GTP KAB01_RS03760 cysteine residues disulfide bond in a protein 3-oxododecanoyl-CoA KAB01_RS15445 hydrolyzing dependent hydrolase: argininosuccinate 2-phospho-4-(cytidine a 2,3-dihydroxybenzoylmethyloxazolinyl- bisphosphate selenodiglutathione acetylmuramyl-L- synthase A: cysK III subunit chi: aminopeptidase: beta-N- an [amino-group carrier cysteine ligase: hydrolyzing) KAB01_RS16355 reductase: ABC -citrate ligase: -citrate ligase: myo-inositol (S)-dihydroorotate KAB01_RS03770 bifunctional UDP-N-acetyl- 3-deoxy-manno- methanesulfinate carbamoyl- DNA ligase KAB01_RS18470 synthase: argG sulfate sulfate [L-threonyl-carrier protein] N-hydroxyhistamine guanine and guanosine salvage II class 1 fructose- α sulfite alanine amidase cysteine synthase KAB01_RS01365 pepP acetylhexosaminidase: protein]-C-terminal- KAB01_RS18315 subunit B: gyrB ADP KAB01_RS03760 transporter 5'-diphospho)-2-C- dADP phosphoribosylaminoimidazolecarboxamide -D-glucosamine octulosonate acetyl-CoA C- L-arginino- LigA: ligA [+ 2 isozymes] KAB01_RS09070 KAB01_RS09070 bisphosphatase: L-ornithine phosphate AmpD: ampD CysM: cysM [+ 8 isozymes] nagZ γ-(5-phospho-L- [+ 3 isozymes] KAB01_RS03770 of sulfate RS17505 a short a short methyl-D-erythritol N 1 -citryl-N 3 -dec-2- N 1 -citryl-N 3 -decanoyl- formyltransferase/IMP cyclohydrolase: purH cytidylyltransferase: acyltransferase succinate RS09770 2-C-methyl-D- quinone-dependent KAB01_RS14550 synthase: glutamyl)-L-glutamate butanoate 4-nitrophenol a negatively ADP chain RS09555 chain enoyl-N 3 -hydroxy- N 3 -hydroxy-1,3- acinetobactin dGDP kdsB FadA: fadA a peptide with γ-L-glutamyl- sulfate RS17435 sulfate erythritol 2,4- dihydroorotate pyrimidine deoxyribonucleotides guanine and guanosine salvage guanosine an aldehyde FMN carA carB γ an (S)-2- a proteinogenic canavaninosuccinate supercoiled DNA fatty acid fatty acid 1,3-diaminopropane diaminopropane non-ribosomal glutathioselenol a peptidoglycan dimer with L-alanyl- -D-glutamyl- acetate [DNA] NMN a halide anion an N-terminal N-acetyl-D- D-alanine cyclodiphosphate dehydrogenase: IMP de novo biosynthesis I F6P CMP-Kdo decanoyl-CoA methanesulfonate carbamoyl L-selenocysteine AMP hydroxycarboxylate [DNA] amino acid GlcNAc 2,4- peptide synthetase pentapeptide stem (meso- meso-2,6-diaminopimeloyl- L-proline muramate Peptide RS13375 Peptide synthase: ispF 2,4- KAB01_RS12875 UDP CTP hydrogen sulfide phosphate fluoride CrcB fluoride diaminobutanoate- subunit BasB: basB glucose-6- ornithine diaminopimelate containing) D-alanyl-D-alanine diaminobutanoate- orotate PRPP ribonucleotide- guanosine acyl-CoA FMNH2-dependent argininosuccinate 2-C-methyl-D-erythritol- -N 1 -citryl-N 3 -dec-2- 1 3 dATP adenine and phosphate carbamoyltransferase: RS10275 potassium- -N -citryl-N - diphosphate pyrimidine/purine guanine dehydrogenase: alkanesulfonate synthase: argG RS09520 2,4-cyclodiphosphate 3 3 adenosine isomerase: pgi argF sulfite RS04025 sulfite + + enoyl-N -hydroxy- decanoyl-N KAB01_RS13680 monooxygenase: assimilatory 2-aminoethylphosphonate 2503 34 a 2'- an unstable K transporting K pre-acinetobactin orotate reductase: CDP nucleoside phosphorylase: adenine 3-phenyl-2- a [protein]-S- a uridine + a [protein]- 1,3-diaminopropane salvage VI D-glucopyranose hydrogen selenide L-citrulline 2,3- a holo-[VibB aryl- adenosylcobinamide ammonium NAD H O chloroacetaldehyde DHAP a DNA segment DNA with lesion ATPase flavodoxin- -hydroxy-1,3- phosphoribosyltransferase: dGTP KAB01_RS03760 KAB01_RS01830 xanthine [+ 5 isozymes] ssuD sulfate reduction III degradation I in 23S rRNA oxopropanoate tyr sulfanyl-L-cysteine in tRNA deoxyribonucleoside [DNA] a PII protein 2 L-histidine RecA filament- ligase: ribonucleotide- 6-phosphate dihydroxybenzoate carrier protein] UTP histidine kinase: dependent diaminopropane pyrE KAB01_RS03770 guanine phosphoribosyltransferase: DsbA family 5'-triphosphate bifunctional aldehyde NAD(P)H- DDE-type excinuclease DNA complexDNA predicted cyanate RS07290 cyanate KAB01_RS09085 adenosine diphosphate (2E)-dec-2-enoyl-CoA sulfite (2-aminoethyl) KAB01_RS01520 (E)-4-hydroxy- ligase: dUDP KAB01_RS16550 oxidoreductase: sulfate adenosylcobinamide dehydrogenase dependent glycerol- integrase/ ABC subunit repair ABC N 5 -2,4- KAB01_RS09085 preQ biosynthesis reductase: sulfate phosphonate2-aminoethylphosphonate- polyphosphate metabolism 23S rRNA aspartate/ tRNA 2- kinase/ nitrite (NADP(+)): 3-phosphate transposase/ sensor histidine UvrA: uvrA taurine taurine 3-methylbut- 0 adenosine kinase: xanthine KAB01_RS01710 enoyl-CoA (2,3- DNA polymerase [protein-PII] protein transporter RS09190 diaminobutanoate- 5 orotidine 5'- KAB01_RS03760 hypoxanthine a [DsbB protein] a [DsbA protein] (adenine(2503)-C(2) thiouridine(34) reductase: porin chloride RS07060 chloride 2-enyl- N -2,4- acinetobactin an electron- an intra- adenylyltransferase: -pyruvate tyrosine/aromatic III subunit chi: adenosylcobinamide- uridylyltransferase: KAB01_RS07380 dehydrogenase: recombinase: kinase KdpD: [+ 2 isozymes] RecO: of taurine 1 3 phosphate KAB01_RS10875 KAB01_RS03770 phosphoribosyltransferase: phosphoribosyltransferase: hpt carrying a with reduced L- hydratase: phosphate acquisition )-methyltransferase dihydroxybenzoyl) synthase nirD nirB N -citryl-N -dec-2- diaminobutanoate-N cysD cysN DNA without 2+ 2+ diphosphate KAB01_RS16550 transfer quinol protein disulfide KAB01_RS00670 transaminase: phnW long chain aminotransferase: adenylate KAB01_RS01365 phosphate glnD [+ 2 isozymes] KAB01_RS12895 KAB01_RS01185 KAB01_RS12255 recO Mg MgtA Mg enoyl-N 3 -hydroxy- 1 3 AMP Fatty Acid and Lipid Biosynthesis disulfide bond cysteine residues APS RlmN: rlmN MnmA: mnmA a [protein]- lesion a stabilized allantoin RS07885 allantoin synthase: ispG -citryl-N -decanoyl- GTP orotidine-5'- dUTP dCDP phosphonoacetaldehyde polyphosphate KAB01_RS00525 guanylyltransferase: 2-chloroacetate sn-glycerol [+ 2 isozymes] 3 superpathway of pyrimidine hypoxanthine GMP (S)-3- synthase: entE [+ 7 isozymes] a DNA segment N-phospho- RecA filament- (E)-4-hydroxy-3- 1,3-diaminopropane N -hydroxy-1,3- taurine a phosphate cobU 3-phosphate GTP cyclohydrolase phosphate nucleobases salvage phosphoadenylyl- nitrite L-histidine DNA complex 2+ 2+ nucleoside triphosphate phosphoribosyltransferase: hpt hydroxydecanoyl-CoA degradation IV monoester phosphonoacetaldehyde 2503 3-(4- 34 in reverse Mg RS16895 Mg methylbut-2-en- baumannoferrin diaminopropane decarboxylase: palmitate biosynthesis (type II fatty acid synthase) a 2-methyladenine a [protein]- a 2-thiouridine adenosyl-cobinamide a uridylylated hemin RS13030 hemin I FolE: folE pyrophosphohydrolase: octanoyl-[acyl-carrier stearate biosynthesis gondoate biosynthesis 3-hydroxyacyl-CoA acid phosphatase: sulfate reductase: hydrolase: KAB01_RS07620 polyphosphate 5'-deoxyadenosine hydroxyphenyl) a 2,3- orientation RS09105 1-yl diphosphate A synthase: baumannoferrin 7,8-dihydroneopterin 3'-triphosphate pyrF uracil in 23S rRNA met phe L-cysteine in tRNA [DNA] phosphate PII protein RS04240 uracil xanthine and mazG dCTP GMP protein] biosynthesis II (bacteria and plants) (anaerobic) N-end rule pathway I (prokaryotic) dehydrogenase: taurine KAB01_RS09950 KAB01_RS15445 kinase 1: ppk1 pyruvate dihydroxybenzoyl- KAB01_RS09090 B synthase: (mitochondria, yeast) exopolyphosphatase: ppx Mg 2+ RS02020 Mg 2+ L-cystine RS14105 L-cystine KAB01_RS09090 UMP phosphoribosyltransferase: upp xanthosine salvage dUTP an acetoacetyl-[acp] leucyl/phenylalanyl- KAB01_RS07435 taurine phosphate acetaldehyde polyphosphate [VibB] 4-hydroxy- 6-carboxytetrahydropterin sulfite baumannoferrin A UMP diphosphatase: dut a palmitoyl-[acp] a malonyl-[acp] an oleoyl-[acp] 2-oxoglutarate decarboxylation to succinyl-CoA Respiration tRNA--protein dioxygenase: kinase 1: ppk1 3-methylbut- synthase: KAB01_RS08780 UMP 3-oxoacyl-ACP an acetoacetyl-[acp] 3-oxodecanoyl-CoA tauD a metal a metal + + baumannoferrin B CMP beta-ketoacyl- 966 38- a [ribosomal Na RS18785 Na kinase: xanthosine dUMP 3-oxoacyl-ACP transferase: an N-terminal 6-[1-hydroxyethyl]-7- a cytosine 32 an [L-cysteine RNase III mRNA a guanine a uridine a [protein]- dCDP a mismatched RS15060 2-enyl UMP kinase: pyrH phosphorylation reductase ACP synthase II: a [2-oxoglutarate a [protein] 2-aminoacetaldehyde an L-phenylalanyl- pimeloyl-CoA FMN NAD(P)H H + FMN NADH H + chitin protein L3]- cation cation 6-carboxy-5,6,7,8-tetrahydropterin pyrH reductase KAB01_RS04405 fatty acid Phe methyl-7,8-dihydropterin desulfurase]-S- processing ala in 16S rRNA 40 in tRNA L-tyrosine DNA base pair RS03595 4-hydroxy- diphosphate pyrimidine/purine thymidylate FabG: fabG KAB01_RS04355 beta-ketoacyl- dehydrogenase an N-terminal N-terminal L- long chain arginyl-[protein] [tRNA ] in tRNA ribonucleotide- RS16270 a purine RS18235 a purine CMP FabG: fabG a 3-oxooctadecanoyl- oxidation 2-amino-4-hydroxy-6- sulfanyl-L-cysteine 16S rRNA RluA family L-glutamine50S ribosomal polysaccharide DNA 3-methylbut- reductase: UDP nucleoside phosphorylase: synthase: thyA pyrimidine deoxyribonucleotide 6 arginyl-[protein] acetyl-CoA diphosphate a metal a metal UDP 3-oxoacyl-ACP ACP synthase II: E2 protein] N 2-oxoglutarate leucyl-L-arginine hydrogen sulfide polyphosphate hydroxymethyldihydropteridine (guanine(966)-N(2) pseudouridine biosynthesis mismatch RS02445 2-enyl ispH 7-carboxy-7-deazaguanine KAB01_RS01830 (d)CMP kinase: phosphorylation 3-oxoacyl-ACP [acp] complex beta-N- protein L3 reductase: cation cation dTMP reductase KAB01_RS04355 -lipoyl-L-lysine dehydrogenase leucyl/phenylalanyl- diphosphokinase: tRNA 2- FMN flavin reductase: )-methyltransferase synthase: tyrosine repair Zn 2+ RS00880 Zn 2+ diphosphate synthase QueE: queE xanthine KAB01_RS08805 reductase subunit alpha 8-amino-7- acetylhexosaminidase: N(5)-glutamine KAB01_RS03760 dTMP dCMP FabG: fabG 3-oxoacyl- 2-oxoglutarate KAB01_RS12275 ribonuclease reductase: msuE KAB01_RS03635 CDP dTMP kinase: FabG: fabG E1 component: leucyl/phenylalanyl- FadB: fadB tRNA--protein thiocytidine(32) oxononanoate nagZ 2 RsmD: rsmD KAB01_RS00590 methyltransferase: autokinase: protein reductase: gln xanthine dTMP kinase: (d)CMP kinase: a (3R)-3- ACP dehydrogenase III: rnc flavin reductase: FMN an N - KAB01_RS03770 a metal RS08135 a metal 7-carboxy-7-deazaguanine UTP KAB01_RS14380 a (3R)-3- an (11Z)-3-oxo- KAB01_RS15100 tRNA--protein transferase: 2-amino-4-hydroxy-6- synthetase synthase: 966 [+ 3 isozymes] prmB KAB01_RS00400 MutS: mutS ispH IPP UTP KAB01_RS14380 KAB01_RS08805 reductase acetyl-CoA C- methylguanine 38- a [ribosomal a [protein]- CDP a properly cation cation RS15655 phosphoribosyltransferase: hydroxybutanoyl-[acp] hydroxybutanoyl-[acp] icos-11-enoyl-[acp] E1 component: transferase: KAB01_RS04405 hydroxymethyldihydropteridine TtcA: ttcA KAB01_RS04080 KAB01_RS03635 reductase: msuE a pseudouridine RS03405 RS02825 7-cyano-7-deazaguanine CTP synthase: KAB01_RS16550 dTDP dTDP dCDP FabG: fabG KAB01_RS15100 a [protein] acyltransferase N-acetyl-D- in 16S rRNA 40 in tRNA protein L3]- L-tyrosine matched 3-hydroxyacyl- an N-terminal KAB01_RS04405 Aromatic Compound Degradation diphosphokinase: folK RNase III chitin 5 synthase QueC: queC CTP synthase: KAB01_RS10755 CTP 3-hydroxyacyl- 3-oxoacyl-ACP N-terminal L- FadA: fadA [1-(2-amino-7-methyl-4-oxo- glucosamine N -methyl- phosphate DNA base pair a metal a metal 3-oxoacyl- [+ 3 isozymes]a [2-oxoglutarate a [2-oxoglutarate 32 an [L-cysteine an mRNA fragment processing RS03490 KAB01_RS10755 ACP dehydratase reductase L-lysyl-[protein] L-phenylalanyl-L- a 2-thiocytosine + + cation cation 7-cyano-7-deazaguanine CTP ACP dehydratase ACP leucyl-L-lysine Phe 7,8-dihydro-3H-pteridin- desulfurase]- (8S)-8-amino-7- FMNH NAD(P) FMNH NAD L-glutamine XMP FabZ: fabZ dehydrogenase dehydrogenase octanoyl-CoA arginyl-[protein] a tRNA in tRNA mRNA coenzyme A 2 2 FabZ: fabZ FabG: fabG catechol degradation III 6-yl)]ethyl diphosphate oxononanoate synthase: KAB01_RS05175 reductase E2 protein] N 6 E2 protein] N 6 -S- aromatic compounds degradation via β-ketoadipate 4-sulfocatechol urate conversion to allantoin II L-cysteine CTP dTTP dTTP dCTP 3-oxoacyl-ACP (ortho-cleavage pathway) shikimate degradation I a metal a metal MacB a (2E)-but-2-enoyl-[acp] FabG: fabG -dihydrolipoyl- succinyldihydrolipoyl- acyl-CoA degradation RS10295 RS07555 DMAPP preQ a (2E)-but-2-enoyl-[acp] reductase cation cation porin 0 a (3R)-3- dehydrogenase: β L-lysine L-lysine catechol protocatechuate urate a methylated a peptidoglycan dimer (meso N-acetyl- -D-glucosamine- all-trans- β-D-fructofuranose 2552 UDP enoyl-ACP hydroxyoctadecanoyl- FabG: fabG KAB01_RS13680 4-sulfocatechol shikimate an N-terminal an L-phenylalanyl- isethionate a [release factor]- uridine (6R)-L-erythro-6,7- aminomalonate a [protein]-L- enoyl-ACP Pentose Phosphate Pathways FAD-dependent 2-oxoglutarate nucleobase -diaminopimelate containing) 1,6-anhydro-N- hexaprenyl 1-phosphate 3',5'-ADP a metal a metal reductase: [acp] catechol 1,2- catechol protocatechuate L-lysyl-[protein] [tRNA Phe ] 4-aminobenzoate L-glutamine in 23S rRNA dihydrobiopterin ribonucleotide- methionine RS17490 reductase: a (3R,11Z)-3-hydroxy- [+ 5 isozymes] glucose/quinate/ within DNA acetyl-β-D-muramate diphosphate peptide chain 23S rRNA oxygen- bifunctional peptide- cation cation KAB01_RS02885 3-hydroxyacyl- dioxygenase: catA protocatechuate 3,4- 3,4-dioxygenase: urate hydroxylase 3'(2'),5'- diphosphate RS15585 KAB01_RS02885 icos-11-enoyl-[acp] shikimate family release factor (uridine(2552)-2'-O) insensitive aspartate methionine ACP 2-oxoglutarate pentose phosphate pathway (2E)-oct-2-enoyl-CoA cis,cis-muconate catechol 1,2- dioxygenase: pcaG pcaH quinate degradation I pcaG pcaH HpxO: hpxO D-alanyl-D-alanine FMNH2-dependent fructose- bisphosphate reductase: glutaminyl-tRNA gln Aminoacyl-tRNA Charging 2-oxoisovalerate decarboxylation to isobutanoyl-CoA membrane-bound leucyl/phenylalanyl- alpha-ketoglutarate- N(5)-glutamine -methyltransferase NAD(P)H transaminase/ (S)-S-oxide a metal a metal a butanoyl-[acp] dehydratase 3-hydroxyacyl- dehydrogenase (non-oxidative branch) I dioxygenase: catA 3-sulfomuconate (S)-5-hydroxyisourate endopeptidase beta-N- 4-hydroxybenzoate nucleotidase CysQ: KAB01_RS03760 RS01110 AdeK biosynthesis via transamidation a butanoyl-[acp] 3-carboxy-cis,cis-muconate PQQ-dependent tRNA--protein dependent alkanesulfonate bisphosphate methyltransferase: RlmE: rlmE nitroreductase: aspartate 4- reductase cation cation RS02590 FabZ: fabZ ACP dehydratase E1 component: enoyl-CoA muconate PBP7/8: pbpG acetylhexosaminidase: octaprenyltransferase: a 2'-O- KAB01_RS08925 KAB01_RS03770 an [apo BCAA D-ribulose cis,cis-muconate L-quinate dehydrogenase: hydroxyisourate transferase: dioxygenase AlkB: monooxygenase: aldolase class II: prmC nfsB decarboxylase: MsrA: msrA beta-ketoacyl- FabZ: fabZ KAB01_RS15100 hydratase: cycloisomerase: 3-sulfomuconate nagZ ubiA methyluridine 2552 beta-ketoacyl- a (2E)-octadec- dehydrogenase 5-phosphate 3-carboxy- glucose/quinate/ KAB01_RS15855 [+ 3 isozymes] ssuD KAB01_RS08675 a [release factor]-N 5 (6R)-L-erythro-5,6,7,8- dUDP a protein-L- a metal a metal RS07890 glu ACP synthase II: KAB01_RS00670 KAB01_RS10495 cycloisomerase: hydrolase: uraH KAB01_RS04405 KAB01_RS01785 KAB01_RS12615 AMP RS06250 ACP synthase II: 2-enoyl-[acp] a (2E,11Z)-icosa- 2-oxoglutarate E2 protein] N 6 alpha-ketoacid muconate cis,cis-muconate shikimate family -methyl-L-glutamine in 23S rRNA tetrahydrobiopterin methionine- cation cation tRNA charging KAB01_RS04355 2,11-dienoyl-[acp] dehydrogenase (S)-3- KAB01_RS10710 glucose/quinate/ (S)-2-oxo-4-hydroxy-4- 3-all trans- gly (S)-S-oxide KAB01_RS04355 enoyl-ACP -lipoyl-L-lysine dehydrogenase ribulose- ribose-5- (+)-muconolactone cycloisomerase: cycloisomerase: membrane-bound a peptidoglycan with 1,6-anhydro-N- GlcNAc hydroxyoctanoyl-CoA shikimate family carboxy-5-ureidoimidazoline L-phenylalanyl- a nucleobase β hexaprenyl-4- glycolaldehyde DHAP D-glyceraldehyde enoyl-ACP complex dihydrolipoyl subunit beta: phosphate 3- phosphate KAB01_RS10495 KAB01_RS10710 PQQ-dependent 4-sulfomuconolactone Phe formaldehyde succinate D,D cross-links (meso- D-ala acetyl- -muramate sulfite a metal a metal RS16315 a 3-oxohexanoyl-[acp] reductase: 3-hydroxyacyl-CoA muconolactone membrane-bound L-lysyl-[protein] a tRNA within DNA aminobenzoate RS01915 PilW a 3-oxohexanoyl-[acp] reductase: dihydrolipoyllysine- dehydrogenase: KAB01_RS09385 epimerase: isomerase (2-carboxy-2,5-dihydro- dehydrogenase: 2-oxo-4-hydroxy- diaminopimelate containing) cation cation RS15905 tyr a tRNA Tyr KAB01_RS02885 PQQ-dependent gln residue rpe RpiA: rpiA dehydrogenase: Delta- (+)-muconolactone KAB01_RS15855 4-carboxy-5- an L-glutamyl- Gln 3-oxoacyl-ACP KAB01_RS02885 KAB01_RS16275 5-oxofuran-2-yl)-acetate gln a tRNA 3-oxoacyl-ACP succinyltransferase: KAB01_RS07435 isomerase: catC dehydrogenase: ureidoimidazoline Gln reductase a stearoyl-[acp] [+ 2 isozymes] a metal a metal [tRNA ] Ala ser asp glucose/quinate/ KAB01_RS10665 46 10 a [lipoyl-carrier 34 RS01925 Asp-tRNA(Asn) a tRNA ala ser a tRNA tRNA asp reductase a gondoyl-[acp] odhB an [apo BCAA D-xylulose D-ribose 5- (4,5-dihydro-5- decarboxylase: uraD 5-methoxy-6- D-glucopyranose ADP-α-D-glucose an (S)-2- (S)-2- a guanine an N - hydrogen an adenine cation cation elongator tyrosyl-tRNA FabG: fabG an [apo BCAA dehydrogenase 3-oxooctanoyl-CoA muconolactone Delta- 4-carboxymuconolactone shikimate family 3-dehydroshikimate NaMN 3-methylbutanoate glycerophosphoserine glu citrate A(H2) 6 roseoflavin Asp-tRNA(Asn) gly a tRNA Gly phe a tRNA Phe ile a tRNA Ile arg a tRNA Arg his a tRNA His leu a tRNA Leu thr a tRNA Thr met initiator tRNA Met met lys a tRNA Lys cys a tRNA Cys trp a tRNA Trp pro a tRNA Pro glu a tRNA glu FabG: fabG dehydrogenase 5-phosphate phosphate oxofuran-2-yl)-acetate 2-maleylacetate methylbenzimidazole 6-phosphate halocarboxylate a type IV prepilin in tRNA formyltetrahydrofolate peroxide protein]-N -[(R) in tRNA /Glu-tRNA(Gln) tRNA Met E2 protein] N 6 -S-[2- isomerase: catC decarboxylase: pcaC aminobutanoate YfcF glutamine-- Val synthetase: 3-oxoacyl-ACP 6 membrane-bound (S)-(+)-allantoin bifunctional tRNA oxygen- -dihydrolipoyl]- tRNA bifunctional RS15990 amidotransferase: /Glu-tRNA(Gln) val a tRNA 3-oxoacyl-ACP E2 protein] N acetyl-CoA C- 3-oxoadipate a metal a metal RS11925 KAB01_RS20095 asn Asn reductase methylpropanoyl]dihydrolipoyl- PQQ-dependent dehydroshikimate aconitate hydratase (guanosine(46)-N7) insensitive adenosine(34) riboflavin RS01935 amidotransferase: alanine- tRNA ligase/ serine- aspartate- tRNA -dihydrolipoyl- transketolase: maleylacetate L-lysine dihydrolipoyl cation cation gatC gatA gatB reductase FabG: fabG L-lysine acyltransferase enol-lactonase: dehydrogenase: dehydratase: nicotinate-nucleotide-- trehalose-6- acetate- glycerophosphodiester HAD family 2/2-methylisocitrate -methyltransferase NAD(P)H catalase/ deaminase kinase/FAD gatC gatA gatB glycine--tRNA - isoleucine- arginine-- histidine- leucine-- threonine- methionine- methionine- lysine- -tRNA cysteine-- YqeY domain tryptophan- -tRNA proline-- -tRNA glutamate-- tyrosine-- L-lysine KAB01_RS05505 (4,5-dihydro-5-oxofuran-2-yl)-acetate reductase: betB glutamate-- dehydrogenase: [+ 6 isozymes] FabG: fabG stearate FadA: fadA pcaD KAB01_RS10665 KAB01_RS10675 dimethylbenzimidazole phosphate -CoA phosphodiesterase: hydrolase: prepilin peptidase: dehydratase: TrmB: trmB nitroreductase: peroxidase TadA: tadA synthetase: a 5-phosphooxy- ligase: glyQ -tRNA ligase: -tRNA tRNA ligase: -tRNA tRNA ligase: -tRNA -tRNA -tRNA -tRNA ligase: tRNA ligase: fusion protein: -tRNA ligase: valine--tRNA ligase: tRNA ligase: ligase: tRNA ligase: tRNA ligase: a (3R)-3- cysteine ligase: an N 7 - lpdA a metal a metal biotin-carboxyl carrier [+ 2 isozymes] 3-oxoadipate 3-oxoadipate enol- phosphoribosyltransferase: synthase: ligase: acs KAB01_RS16000 KAB01_RS18470 KAB01_RS01850 HPI: katG a hypoxanthine ribF RS02045 RS07990 L-glutamyl- KAB01_RS17010 pheS pheT ligase: ileS KAB01_RS00840 ligase: hisS KAB01_RS02915 ligase: thrS ligase: metG ligase: metG ligase: lysS alaS KAB01_RS06855 KAB01_RS12100 ligase: trpS serS KAB01_RS15290 KAB01_RS15690 aspS KAB01_RS17445 KAB01_RS18825 a (3R)-3- hexanoyl-CoA 3-dehydroquinate 3-oxoadipate KAB01_RS18315 KAB01_RS12210 46 nfsB a [lipoyl-carrier[+ 2 isozymes] ammonium hydroxyhexanoyl-[acp] long-chain-fatty- protocatechuate cobT KAB01_RS04060 methylguanine 10 34 cation cation Gln hydroxyhexanoyl-[acp] protein assembly enol-lactonase: lactonase: pcaD benzoate degradation [+ 2 isozymes] an N -formyl- 6 in tRNAs roseoflavin [tRNA ] acid--CoA ligase: 2-oxo acid D-sedoheptulose D-glyceraldehyde D-threo-isocitrate in tRNA protein]-N -[(R RS11970 an L-methionyl- 3-hydroxyacyl- acyl-CoA pcaD 3-oxoadipate enol- type I 3- I (aerobic) 3-methylbutanoyl- 7,8-dihydrofolate )-lipoyl]-L-lysine 5'-phosphate RS08685 an L-phenylalanyl- an L-isoleucyl- an L-arginyl- an L-histidyl- an L-leucyl- an L-threonyl- an L-methionyl- an L-lysyl- an L-alanyl- an L-cysteinyl- an L-glutaminyl- an L-tryptophanyl- an L-seryl- an L-valyl- an L-prolyl- an L-aspartyl- an L-glutamyl- an L-tyrosyl- an L-asparaginyl- 3-hydroxyacyl- KAB01_RS01125 a [biotin carboxyl- dehydrogenase 7-phosphate 3-phosphate sn-glycerol γ A H O a metal a metal Asp-tRNA(Asn) a glycyl-[tRNA Gly ] [elongator ACP dehydratase dehydrogenase: lactonase: pcaD dehydroquinate 5-methoxy-6- α,α-trehalose CoA diphosphate ser a cleaved type -L-glutamyl-(S)- 2 RS07035 [tRNA Phe ] [tRNA Ile ] [tRNA Arg ] [tRNA His ] [tRNA Leu ] [tRNA Thr ] [initiator tRNA Met ] [tRNA Lys ] [tRNA Ala ] [tRNA Cys ] [tRNA Gln ] [tRNA Trp ] [tRNA ser ] [tRNA Val ] [tRNA Pro ] [tRNA asp ] [tRNA Glu ] [tRNA Tyr ] [tRNA Asn ] ACP dehydratase [+ 3 isozymes] carrier protein]-L-lysine subunit E2: 3-oxoadipate nicotinate ADP AMP 3-phosphate a (2R)-2- a peptide cation cation /Glu-tRNA(Gln) tRNA Met ] FabZ: fabZ KAB01_RS13680 dehydratase: benzoate methylbenzimidazole 6-phosphate a halide anion IV prepilin 2-aminobutanoate TypA FabZ: fabZ biotin--[acetyl- KAB01_RS18100 hydroxy fatty acid amidotransferase: transaldolase: tal [+ 5 isozymes] 3-oxoadipate KAB01_RS10680 chlorogenic benzoate 1,2- ribotide phosphate a (2E)-hex-2-enoyl-[acp] stearoyl-CoA CoA-carboxylase] 3-oxoacid CoA- anthranilate a metal a metal gatC gatA gatB 2-oxo acid type II 3- acid degradation dioxygenase: a (2E)-hex-2-enoyl-[acp] ligase: transferase 3-oxoacid CoA- degradation cation cation dehydrogenase D-erythrose (2E)-hexenoyl-CoA dehydroquinate benB benA RS15550 RS09155 enoyl-ACP KAB01_RS04020 F6P subunit A: transferase subunit trans-5-O- I (aerobic) 3,5-cyclohexadiene- a very-long- all-trans- an (R)-2- 3-(all-trans- guanine 37 4-nitrophenyl (3R,5S)-3- an adenosine 34 a protein-L- RS04285 subunit E2: 4-phosphate dehydratase: aroQ 5-methoxybenzimidazole NaMN a 5-L-glutamyl- a ribonucleoside a holo [PedN acyl- an L-aspartyl- an L-glutaminyl- Amino Acid Biosynthesis enoyl-ACP KAB01_RS10725 A: KAB01_RS10725 an amino acid nonaprenyl nonaprenyl) Phe Asn hydroxy-1- Arg2 methionine- ala ala RS18940 reductase: a [biotin carboxyl- KAB01_RS09390 transketolase: enoyl-CoA caffeoyl-D-quinate anthranilate 1,2-diol-1-carboxylate [peptide] chain fatty acid 4-hydroxybenzoate halocarboxylate 5'-monophosphate carrier protein] in tRNA [tRNA ] palmitate in [tRNA ] [tRNA Gln ] reductase: KAB01_RS02885 carrier protein]-N hydratase: [+ 2 isozymes] [+ 2 isozymes] diphosphate benzene-1,2-diol tRNA Asp-tRNA(Asn) pyrroline-5- tRNA (R)-S-oxide KAB01_RS05505 3-dehydroshikimate anthranilate 1,2- 1,6- bifunctional 3- bifunctional ACP S- peptide- RS16055 superpathway of L- KAB01_RS02885 6 -biotinyl-L-lysine TCA cycle TCA cycle I (prokaryotic) KAB01_RS00670 dioxygenase: demethylubiquinone 3- metallophosphatase/ (guanosine(37)-N1) /Glu-tRNA(Gln) carboxylatepyrroline-5- adenosine(34) L-histidine biosynthesis L-lysine biosynthesis I superpathway of L-serine alanine L-arginine biosynthesis II (acetyl cycle) L-glutamate biosynthesis III L-proline biosynthesis L-cysteine biosynthesis I [+ 2 isozymes] 3-oxoadipyl-CoA 3-oxoadipyl-CoA dihydroxycyclohexa- nicotinate-nucleotide-- long-chain-acyl- HAD family malonyltransferase: methionine isoleucine biosynthesis I a hexanoyl-[acp] dehydroshikimate antC antB antA 4-hydroxybenzoate O-methyltransferase/2- 5'-nucleotidase: -methyltransferase amidotransferase: carboxylate deaminase and glycine biosynthesis I racemization I (from L-glutamate) a hexanoyl-[acp] D-glyceraldehyde (S)-3- 2,4-diene-1- dimethylbenzimidazole gamma- CoA synthetase: hydrolase: fabD (R)-S-oxide dehydratase: 1 TrmD: trmD reductase: TadA: tadA hydroxyhexanoyl-CoA catechol carboxylate octaprenyltransferase: octaprenyl-6-hydroxy KAB01_RS09690 a malonyl[PedN an N - gatC gatA gatB 34 reductase RS04470 RS11760 beta-ketoacyl- acetyl-CoA 3-phosphate 3-oxoadipyl-CoA 3-oxoadipyl-CoA trans-caffeate L-quinate phosphoribosyltransferase: glutamyltransferase: ggt KAB01_RS02205 KAB01_RS18470 an L-asparaginyl- an inosine RS04520 oxaloacetate PRPP N-acetylglutamyl- 2-oxoglutarate KAB01_RS10675 ubiA 37 KAB01_RS03240 asp ser a [biotin carboxyl- 3-hydroxyacyl-CoA thiolase: pcaF dehydrogenase: phenol methylase: 5'/3'-nucleotidase acyl-carrier methylguanine Arg2 MsrB: msrB 3-phospho-D-glycerate ala amino-acid N- phosphate glu beta-ketoacyl- ACP synthase II: thiolase: pcaF cobT [+ 2 isozymes] [tRNA Asn ] Hyp in [tRNA ] a [protein]-L- aspartate/ NADP-specific glutamate KAB01_RS06675 KAB01_RS00330 protein] in tRNA Phe RS08420 ATP : phosphoglycerate acetyltransferase: ACP synthase II: KAB01_RS04355 carrier-protein dimer]- oxaloacetate dehydrogenase: [+ 3 isozymes] [+ 3 isozymes] protocatechuate α 2-methoxy- SurE: surE tyrosine/aromatic alanine dehydrogenase: gdhA glutamate 5-kinase: serine 6 an -(5-L- a very-long-chain 4-nitrophenol palmitate methionine KAB01_RS06485 dehydrogenase: serA KAB01_RS04355 N -biotinyl-L-lysine KAB01_RS07435 diphosphate 3-nonaprenyl-4- 6-(all-trans- a ribonucleoside aminotransferase: phosphoribosyltransferase racemase: alr argA glutamate synthase KAB01_RS14230 acetyltransferase: 2-methylcitrate succinyl-CoA succinyl-CoA catechol 5-methoxybenzimidazole glutamyl)- a peptide AMP fatty acyl-CoA a (2R)-2- γ a 3-oxooctanoyl-[acp] acetyl-CoA acetyl-CoA nicotinate hydroxybenzoate a halide anion nonaprenyl)phenol RS11775 KAB01_RS00525 regulatory subunit: 3-phosphooxypyruvate alanine -L-glutamyl synthase: prpC amino acid L-aspartyl-4-phosphate bifunctional N-acetyl-gamma- large subunit: gltB KAB01_RS07950 a 3-oxooctanoyl-[acp] carboxylase carboxylase 3-oxohexanoyl-CoA ribotide phosphate hydroxy fatty acid KAB01_RS06500 racemase: alr 5-phosphate malate dehydrogenase citrate (Si)-synthase: gltA NADH repair (prokaryotes) RS17365 bifunctional 3-phosphoserine/ glutamate N- glutamyl-phosphate glu serine O- 3-oxoacyl-ACP carboxyltransferase biotin RS00985 1-(5-phospho- D-ala (quinone): mqo acetyl-CoA C- RS03555 aspartate aspartate- phosphohydroxythreonine acetyltransferase/ reductase: glutamate-5- acetyltransferase: 3-oxoacyl-ACP reductase subunit beta: carboxylase malate dehydrogenase: β acetyltransferase: all-trans- an sn-glycero-3- a 3-(all-trans 37 transaminase/ -D-ribosyl)-ATP semialdehyde transaminase: serC amino-acid KAB01_RS10825 semialdehyde cysE reductase FabG: fabG NADH a dietary all- a guanine an L-glutamyl- a supercoiled acetylglutamate KAB01_RS15950 subunit: accC KAB01_RS16505 KAB01_RS11840 5-hydroxybenzimidazole NaMN aryl-carrier protein 2-methylbutanoate heptaprenyl phospho-N-(acyl) -polyprenyl) a holo [PedD acyl- acetaldehyde trp a protein with RS03245 aspartate 4- bifunctional dehydrogenase: acetyltransferase dehydrogenase: FabG: fabG 2,3-dihydroxybenzoate 4-hydroxybenzoate trans-retinyl ester in tRNA [tRNA Gln ] duplex DNA kinase: argB 3-oxoacyl-ACP a [carboxyl-carrier [+ 2 isozymes] purine nucleotides degradation II (aerobic) Nucleoside and Nucleotide Degradation diphosphate ethanolamine benzene-1,2-diol carrier protein] tRNA UvrD-helicase aldehyde a disulfide bond decarboxylase: phosphoribosyl- asd O-phospho-L-serine ArgJ: argJ N-acetyl-L-glutamate KAB01_RS02670 O-acetyl-L-serine 6 (S)-malate citrate purine ribonucleosides degradation bifunctional 3- Asp-tRNA(Asn) protein- glu gln N-acetyl-L-glutamate hydrogen sulfide 3-oxoacyl-ACP reductase protein dimer]-N - ACP S- (guanosine(37)-N1) domain-containing dehydrogenase tryptophan 7- KAB01_RS12615 AMP 5-semialdehyde acetate- demethylubiquinone 3- triacylglycerol /Glu-tRNA(Gln) disulfide RS08515 RS09815 L-aspartate 4- L-glutamate-5- reductase FabG: fabG carboxybiotinyl-L-lysine bifunctional aconitate butanoyl-CoA nicotinate-nucleotide-- malonyltransferase: -methyltransferase protein: (NADP(+)): halogenase: AdeC cyclohydrolase/ bifunctional phosphoserine -CoA 4-hydroxybenzoate glycerophosphodiester O-methyltransferase/2- lipase: amidotransferase: reductase asp semialdehyde glutamine- N-acetylornithine L-tryptophan biosynthesis semialdehyde FabG: fabG hydratase 2/2- AMP dimethylbenzimidazole (2,3-dihydroxybenzoyl) fabD TrmD: trmD KAB01_RS01995 KAB01_RS10460 KAB01_RS02815 RS08305 phosphoribosyl- phosphatase/homoserine cysteine a (3R)-3- acyl-CoA adenosine ligase: acs octaprenyltransferase: phosphodiesterase: octaprenyl-6-hydroxy KAB01_RS17200 a malonyl- an N 1 - gatC gatA gatB a protein withDsbD: dsbD 4-hydroxy- hydrolyzing bifunctional aminotransferase: a (3R)-3- fumarate hydratase: methylisocitrate (R)-NADHX phosphoribosyltransferase: adenylate synthase: entE an L-glutaminyl- 7-chloro-L- ATP diphosphatase phosphotransferase synthase A: cysK hydroxyoctanoyl-[acp] dehydrogenase: ubiA KAB01_RS16000 phenol methylase: [PedD acyl- methylguanine 37 [+ 2 isozymes] [+ 2 isozymes] carbamoyl- KAB01_RS17075 dehydratase: bifunctional cobT Gln tryptophan reduced L- aspartate kinase: tetrahydrodipicolinate glutamate N- hydroxyoctanoyl-[acp] KAB01_RS02620 5'/3'-nucleotidase [tRNA ] a single acetate HisIE: ThrH: thrH phosphate gln cysteine synthase 3-hydroxyacyl- (Kdo) -lipid A KAB01_RS12210 ADP-dependent KAB01_RS13680 adenosine (2S)-2- a 2-methoxy-KAB01_RS00330 carrier protein] in tRNA cysteine residues RS03670 KAB01_RS06485 synthase: acetyltransferase/ chorismate 2 phosphatidylserine and class II fumarate SurE: surE stranded DNA KAB01_RS01950 phosphoserine synthase: (S)-1-pyrroline- CysM: cysM 3-hydroxyacyl- ACP dehydratase biosynthesis I (E. coli) NAD(P)H-hydrate [+ 5 isozymes] deaminase: add a 2,3-dihydroxybenzoyl- methylbutanoyl- diphosphate 3-heptaprenyl-4- an N- 6-(all-trans- all-trans-retinol a fatty acid RS18040 KAB01_RS18580 amino-acid phosphatidylethanolamine hydratase: fumC bifunctional 5-hydroxybenzimidazole AMP sn-glycerol RS18110 SecD β phosphatase SerB: serB carA carB 5-carboxylate ACP dehydratase FabZ: fabZ fumarate cis-aconitate dehydratase/ adenosine nicotinate [aryl-carrier protein] CoA hydroxybenzoate acylethanolamine polyprenyl)phenol L-aspartyl- 1-(5-phospho- - (2S,4S)-4- acetyltransferase α-Kdo-(2->4)- biosynthesis I crotonyl-CoA metallophosphatase/ ribotide phosphate 3-phosphate anthranilate FabZ: fabZ NAD(P)H-hydrate deaminase: 4-phosphate D-ribosyl)-AMP hydroxy-2,3,4,5- ArgJ: argJ pyrroline-5- cys a (2E)-oct-2-enoyl-[acp] α-Kdo-(2->6)- bifunctional aconitate 5'-nucleotidase: ser carbamoyl phosphate L-ornithine synthase a CDP-diacylglycerol epimerase: KAB01_RS06460 bifunctional tetrahydrodipicolinate carboxylate a (2E)-oct-2-enoyl-[acp] lipid IV (E.lauroyl coli) CDP-diacylglycerol--serine succinate dehydrogenase hydratase 2/2- enoyl-CoA KAB01_RS09690 RS19245 aspartate- 4-hydroxy- N-acetyl-L-ornithine component I: trpE reductase: A flavoprotein subunit: KAB01_RS08490 hydratase: phosphoribosyl- serine enoyl-ACP acyltransferase: O-phosphatidyltransferase: methylisocitrate (S)-NADHX IMP UDP-N-acetyl- decaprenyl-diphospho-N- a Chi-site containing a RecA DNA a 2,3,4-saturated 3-(N-morpholino) 3-(all-trans a 5,6- a cytidine 34 RS08470 semialdehyde tetrahydrodipicolinate KAB01_RS03240 KAB01_RS15110 KAB01_RS00670 xanthosine adenosine inosine guanosine α fumarate a diphthine-[translation 20 cyclic-AMP an aldehyde AMP hydroxymethyltransferase: enoyl-ACP reductase: KAB01_RS02370 pssA dehydratase: adenosine GMP -D-glucosamine acetylmuramoyl-pentapeptide double stranded recombination DL-allothreonine 1,2-diacyl-sn- propanesulfonate -decaprenyl) asp dihydrouracil in tRNA trp a protein RS05560 dehydrogenase: reductase: dapB a 3-sn-phosphatidyl- CTP elongation factor 2] Ata cyclohydrolase/ KAB01_RS13135 anthranilate PRPP reductase: KAB01_RS02885 lauroyl KAB01_RS12210 bifunctional (S)-3- IMP DNA with a blunt end and repair protein glycerol 3-phosphate benzene-1,2-diolbifunctional 3- in tRNA tRNA (cytidine(34) 3',5'-cyclic-AMP aldehyde asd pro L-serine diphthine-- tRNA aromatic amino phosphoribosyl- (S)-2,3,4,5- KAB01_RS02885 acyltransferase: ADP-dependent hydroxybutanoyl-CoA dehydrogenase: undecaprenyldiphospho- demethylubiquinone 3- -2'-O)- phosphodiesterase: dehydrogenase endopeptidase L-aspartate 4- ammonia assimilation cycle III succinate D-threo-isocitrate adenosine 5'/3'-nucleotidase FMNH2-dependent L-aspartate ammonia ligase: dihydrouridine(20/ acid lyase: RS19280 ATP diphosphatase tetrahydrodipicolinate gly ornithine an octanoyl-[acp] α-Kdo-(2->4)KAB01_RS06955 phosphatidylserine NADP-dependent NAD(P)H-hydrate 3-hydroxyacyl-CoA guaB pyrimidine/purine pyrimidine/purine pyrimidine/purine pyrimidine/purine UTP and CTP dephosphorylation I muramoylpentapeptide beta-N- serine phosphatidate O-methyltransferase/2- methyltransferase: cpdA (NADP(+)): La: lon semialdehyde anthranilate deaminase: add SurE: surE exodeoxyribonuclease alkanesulfonate oxidase: KAB01_RS14450 20a) synthase KAB01_RS02795 RS03615 HisIE: 2,3,4,5- carbamoyltransferase: an octanoyl-[acp] -α-Kdo-(2->6) decarboxylase: psd isocitrate dehydrogenase: dehydratase/ dehydrogenase: nucleoside nucleoside nucleoside nucleoside acetylglucosaminyltransferase: hydroxymethyltransferase: cytidylyltransferase: octaprenyl-6-hydroxy KAB01_RS15195 KAB01_RS07380 phosphoribosyltransferase: trpD adenosine bifunctional V: KAB01_RS01990 recD monooxygenase: nadB a diphthamide- DusA: dusA a 2'-O- KAB01_RS01950 ammonium -(lauroyl)-lipid NAD(P)H-hydrate KAB01_RS07435 phosphorylase: phosphorylase: phosphorylase: phosphorylase: UTP murG 20 34 [+ 2 isozymes] tryptamine homoserine tetrahydropyridine- argF an L-1- ADP-forming succinate- KAB01_RS14140 deaminase: metallophosphatase/ XMP KAB01_RS13135 KAB01_RS11180 ssuD phenol methylase: [translation a uracil in tRNA methylcytidine AMP a peptide RS05710 dehydrogenase: 1-(5-phospho-β-D-ribosyl)- 2,6-dicarboxylate N- beta-ketoacyl- IV (E. coli) epimerase: KAB01_RS01830 KAB01_RS01830 KAB01_RS01830 KAB01_RS01830 a carboxylate RS13730 NADP-specific A phosphatidylethanolamine -CoA ligase: sucD sucC NADP-dependent isocitrate KAB01_RS06460 6-(all-trans- KAB01_RS00330 elongation factor 2] in tRNA N-(5-phosphoribosyl)-anthranilate L-alanine glu ACP synthase II: myristoyl-acyl KAB01_RS08490 acetoacetyl-CoA 5'-nucleotidase: CTP synthase: a double stranded DNA GspJ KAB01_RS01420 5-[(5-phosphoribosylamino) succinyltransferase: : icd KAB01_RS09690 5'/3'-nucleotidase decaprenyl-pyrophosphoryl- UDP a CDP-2,3,4-saturated- decaprenyl)-2- 2-iminosuccinate succinate RS03680 biosynthesis III KAB01_RS04355 carrier protein- KAB01_RS10755 with a RecA protein acetaldehyde 3-(N-morpholino) methylideneamino]imidazole- dapD superpathway of branched chain amino acid biosynthesis dehydrogenase: type I phosphatidylglycerol acetyl-CoA C- inosine SurE: surE α-D-ribose-1-phosphate (N-acetylglucosamine)-N- gly diacylglycerol sulfite methoxy-phenol L-homoserine 4-carboxamide phosphoribosylanthranilate 2-oxoglutarate glutamate- dependent NADH loaded 3' overhang propanal N-succinyl-2-amino- superpathway of L- gdhA a 3-oxodecanoyl-[acp] biosynthesis I (plastidic) acetyltransferase: guanosine bifunctional UDP acetylmuramyl-(pentapeptide) 1-(5-phosphoribosyl)-5- isomerase: KAB01_RS15985 cys -ammonia acyltransferase: succinyl-CoA 2-oxoglutarate CTP 6-ketopimelate threonine biosynthesis glutamate long-chain fatty KAB01_RS15875 pyrimidine/purine metallophosphatase/ homoserine kinase: [(5- phosphoribosylamino) pyruvate thr L-citrulline 1-(2-carboxyphenylamino)-1- cysteine desulfurase: ligase: glnA KAB01_RS02370 RS05825 synthase 3-oxoacyl-ACP DHAP [+ 2 isozymes] 5'-nucleotidase: 6 RS03915 RS10670 succinyldiaminopimelate α-D-Kdo-(2->4) acid activation nucleoside pyrimidine/purine 34 a thiocarboxylated a 2'- an N -(1-hydroxy- RS03750 KAB01_RS17645 methylideneamino]imidazole-4- oxaloacetate deoxy-D-ribulose 5-phosphate KAB01_RS07940 a [2-oxoglutarate-dehydrogenase lysine within a uridine an isoprenoid a holo [BryU acyl- 1,6-anhydro-N- an aromatic an unfolded transaminase: dapC acetolactate large reductase NAD(P)H- -α-D-Kdo-(2->6) phosphorylase: nucleoside KAB01_RS09690 a sulfurated [sulfur carrier] SAM an octanoyl-[acp] [SAMP] C- 4-hydroxybenzoate deoxyribonucleoside 2-oxopropyl)- canavaninosuccinate ethanol [DNA] tyr carboxamide isomerase: hisA aspartate/ indole-3-glycerol IscS subfamily a long-chain acetyl-CoA D-ribose 5-phosphate UMP 6 gcv protein H in tRNA diphosphate [DNA] acetyl-β-muramate synthase: threonine argininosuccinate subunit: gltB FabG: fabG dependent glycerol- KAB01_RS01830 CDP E2 protein] N -octanoyl-L-lysine carrier protein] DNA amino acid protein O-phospho- N-succinyl-L,L-2,6- tyrosine/aromatic phosphate cysteine desulfurase: -lipid A (E. coli) fatty acid phosphorylase: terminal glycine 5'-triphosphate [protein]-L-lysine catalase/peroxidase anhydro-N- aspartate/ L-homoserine phosphoribulosylformimino- KAB01_RS02925 ammonia- synthase: argG 3-oxoacyl-ACP 3-phosphate long-chain-acyl- 2-oxoglutarate KAB01_RS01830 xanthosine 5'/3'-nucleotidase ACP S- HPI: katG acetylmuramic polymerase aromatic amino diaminopimelate lyase, aminotransferase: synthase TrpC: trpC KAB01_RS09005 Asp-tRNA(Asn) tyrosine/aromatic chaperonin AICAR-phosphate ilvN ammonium gln reductase dehydrogenase: CoA synthetase: dehydrogenase hypoxanthine SurE: surE lipoyl(octanoyl) tRNA 2- 4-hydroxybenzoate argininosuccinate malonyltransferase: catalase: acid kinase: IV: dinB acid lyase: threonine succinyl- biosynthetic: L-arginino-succinate KAB01_RS00525 ala /Glu-tRNA(Gln) lipoyl synthase: lipA reverse aminotransferase: GroEL: groL RS03960 RS13200 (1S,2R)-1-C-(indol-3- FabG: fabG KAB01_RS12895 KAB01_RS02205 E1 component: guanine bifunctional transferase thiouridine(34) octaprenyltransferase: lyase: argH fabD KAB01_RS10390 KAB01_RS18830 [+ 2 isozymes] KAB01_RS02795 RS06170 synthase: diaminopimelate (S)-2-acetolactate ilvA amidotransferase: sn-glycerol CMP transcriptase: a malonyl- N-acetyl-D- a 2'- KAB01_RS00525 RS06185 imidazole bifunctional yl)glycerol 3-phosphate [+ 3 isozymes] KAB01_RS15100 pyrimidine/purine pyrimidine deoxyribonucleosides degradation metallophosphatase/ lipoyl synthase: lipA LipB: lipB synthase ubiA an aromatic p-tyramine KAB01_RS01415 desuccinylase: argininosuccinate gatC gatA gatB a (3R)-3- 3-phosphate a long-chain Aldehyde Degradation KAB01_RS07475 [BryU acyl- acetaldehyde muramate 6- deoxyribonucleoside a protein glycerol ketol-acid threonine lyase: argH aspartate tryptophan synthase xanthine nucleoside 5'/3'-nucleotidase 5'-nucleotidase: MnmA: mnmA 2-oxo-acid dapE [+ 6 isozymes] hydroxydecanoyl-[acp] fatty acyl-CoA a [glycine-cleavage carrier protein] phosphate 5'-monophosphate thr phosphate reductoisomerase: ammonia-lyase: transaminase/ subunit beta: trpB glycerol-3- dehydrogenase: guanine phosphorylase: 2'-deoxycytidine SurE: surE KAB01_RS09690 L-canavanine fumarate KAB01_RS15540 aspartate 4- 3-hydroxyacyl- phosphate 1-O- L-lactaldehyde a [2-oxoglutarate dehydrogenase acyl-carrier protein complex H protein] a 4-hydroxy-3- CcsA GspK synthase: xdhB xdhA deaminase: guaD KAB01_RS01830 5'-deoxyadenosine 6 34 (R)-lactate a [protein]-L-lysine ilvC arg tryptophan synthase: degradation (aerobic) bifunctional uridine met E2 protein] N -lipoyl-L-lysine an unsulfurated [sulfur carrier] 6 a [SAMP] C- a 2-thiouridine polyprenylbenzoate [DNA] L,L-diaminopimelate decarboxylase: ACP dehydratase acyltransferase acyl-CoA hydrolysis nucleoside N -octanoyl-L-lysine threonine hisH hisF (2R)-2,3- (2Z)-2-aminobut- KAB01_RS15955 trpB metallophosphatase/ terminal glycine in tRNA RS10870 dihydroxy-3- 2-enoate KAB01_RS12615 glu FabZ: fabZ PlsB: plsB deaminase: RS06335 ammonia- ser a 1-acyl-sn (S)-lactaldehyde xanthine 5'-nucleotidase: D-erythro-1- diaminopimelate methylbutanoate asp indole a 2,3,4-saturated KAB01_RS07285 lys RS08830 lys lyase, thymidine KAB01_RS09690 β AICAR (imidazol-4- epimerase: dapF a (2E)-dec-2-enoyl-[acp] -glycerol 3- fatty acyl CoA a single an N-acetyl- - 2030 RNase G biosynthetic: dihydroxy-acid acyl-CoA xanthine a [glycine-cleavage complex H isobutanoate glycerophosphoglycerol (2E,6E)-farnesyl adenine a holo [BryP acyl- MeOH 3-aminopropanal sn-glycerol histidinol RS08970 phosphate 6 D-hexosaminide degradation yl)-glycerol dehydratase: thioesterase: 2'-deoxyuridine pyrimidine/purine cytidine a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine stranded DNA diphosphate protoheme in 23S rRNA a malonyl-[acp] 3-phosphate ilvA L-phenylalanine aspartate kinase: tryptophan synthase enoyl-ACP 1-acyl-sn-glycerol- (S)-lactate dehydrogenase 23S rRNA carrier protein] catalase/peroxidase substrate mRNA 3-phosphate meso-diaminopimelate ilvD KAB01_RS14360 nucleoside betaine-aldehyde glycerol-3- histidinol RS03930 threonine 2-iminobutanoate biosynthesis I KAB01_RS06485 subunit beta: trpB reductase: 3-phosphate accessory protein (adenine(2030)-N(6) ACP S- HPI: katG malonyl-ACP O- RS14260 imidazoleglycerol- pyrimidine/purine phosphorylase: exodeoxyribonuclease glycerophosphodiester beta-N- dehydrogenase: phosphate ribonuclease dehydrogenase: RS15820 ammonia-lyase: 3-methyl-2- tryptophan synthase: KAB01_RS02885 acyltransferase: a 2,3,4-saturated[+ 6 isozymes] FMN-dependent XdhC: xdhC acetate--CoA protoheme IX )-methyltransferase malonyltransferase: methyltransferase phosphate diaminopimelate L-aspartyl- pyrimidine nucleoside KAB01_RS01830 VII: KAB01_RS06740 phosphodiesterase: acetylhexosaminidase: catalase: betB dehydrogenase: G: rng hisD KAB01_RS15540 oxobutanoate chorismate KAB01_RS15955 trpB KAB01_RS16330 fatty acid L-lactate [+ 2 isozymes] lipoyl synthase: lipA ligase: acs farnesyltransferase: RlmJ: fabD BioC: bioC MlaE dehydratase decarboxylase: lysA 4-phosphate ribonucleosides phosphorylase: purine deoxyribonucleosides degradation I KAB01_RS06745 KAB01_RS16000 nagZ a malonyl- KAB01_RS10390 glpD (2Z)-2-aminobut- HisB: hisB a decanoyl-[acyl-carrier protein] [+ 2 isozymes] dehydrogenase thymine lipoyl synthase: lipA cyoE KAB01_RS16485 β-alanine a malonyl-[acp] an mRNA fragment his urate degradation KAB01_RS01830 an N 6 - [BryP acyl- formaldehyde DHAP RS12535 2-enoate 3-(imidazol-4- 2-isopropylmalate branched-chain aspartate- a 1,2-diacyl- LldD: lldD methyl ester lys synthase: leuA amino acid 2-oxobutanoate trp beta-ketoacyl- sn-glycerol cytidine an N-acetyl-β- methyladenine 2030 carrier protein] yl)-2-oxopropyl prephenate semialdehyde a ribonucleoside a single-stranded isobutanoyl-CoA sn-glycerol an alcohol transaminase: ACP synthase II: 3-phosphate pyruvate nucleoside 2'-deoxyadenosine a [glycine-cleavage complex H diphosphate glycerol D-hexosamine in 23S rRNA RS01685 phosphate acetolactate dehydrogenase: 5'-deoxyadenosine 6 oligodeoxyribonucleotide AMP ferroheme o RS01705 (2S)-2- L-methionine biosynthesis III KAB01_RS04355 deaminase: adenosine met protein] N -[(R)-lipoyl]-L-lysine an unsulfurated [sulfur carrier] 5'-monophosphate 3-phosphate RS16980 histidinol- KAB01_RS16140 synthase: prephenate asd phosphatidate isopropylmalate cytidylyltransferase: KAB01_RS07285 deaminase: add RS12195 phosphate KAB01_RS02925 dehydratase: pyrimidine deoxyribonucleotides uridine 2-iminobutanoate 3-isopropylmalate L-aspartate 4- a 3-oxododecanoyl-[acp] KAB01_RS11180 adenosine transaminase: ilvN pheA L-homoserine dephosphorylation uracil 2-deoxy-α- dehydratase: val semialdehyde pyrimidine/purine deaminase: sn-glycero-3- an N-terminal L- 527 1939 a negatively KAB01_RS03380 3-phenyl-2- L-tyrosine biosynthesis I a CDP- nucleoside triphosphate D-ribose 1- a [pyruvate dehydrogenase E2 a proteinogenic an L-arginyl- a [DNA]-3'- (R)-S- a guanine a uracil propane-1,2,3- pyridoxamine (S)-2-aceto-2- 3-oxoacyl-ACP 6 leukotriene-C4 alanyl-[S18 protein L-dopa leuC leuD homoserine homoserine O- diacylglycerol nucleoside 2'-deoxyinosine KAB01_RS06460 2'-deoxyguanosine a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine a protein Arg phosphoethanolamine hydroxyl lactoylglutathione in 16S rRNA in 23S rRNA supercoiled DNA Hyp tricarboxylate RS09205 Pal L-histidinol hydroxybutanoate oxopropanoate reductase pyrophosphohydrolase: phosphate pyrimidine/purine amino acid [tRNA ] 5'-phosphate RS14655 dehydrogenase: acetyltransferase: phosphorylase: of 30S ribosome]ribosomal protein 16S rRNA 23S rRNA DNA FAD-dependent RS04165 phosphate 2-isopropylmaleate ketol-acid bifunctional FabG: fabG CDP-diacylglycerol-- mazG nucleoside (guanine(527)-N(7) (uracil(1939)-C(5)) topoisomerase 4-hydroxyproline tricarballylate aromatic amino pyridoxamine 2-oxobutanoate KAB01_RS01420 chorismate KAB01_RS02575 dCTP dCMP KAB01_RS01830 S18-alanine N- reductoisomerase: aspartate 3-oxoacyl-ACP glycerol-3-phosphate 3- phosphorylase: glycerophosphodiester exodeoxyribonuclease hydroxyacylglutathione )-methyltransferase -methyltransferase IV subunit B: parE epimerase: dehydrogenase acid lyase: 5'-phosphate pyrimidine/purine pyrimidine/purine acetyltransferase: 3-isopropylmalate ilvC transaminase/ O-acetyl-L- reductase phosphatidyltransferase: uracil KAB01_RS01830 lipoyl synthase: lipA gamma- arginyltransferase: phosphodiesterase: III: xth hydrolase: gloB RsmG: rsmG RlmD: rlmD KAB01_RS07350 TcuA: tcuA KAB01_RS02795 oxidase: pdxH acetolactate L-homoserine an N-terminal N-acetyl-rimI an N 7 - [+ 2 isozymes] dehydratase: aspartate 4- homoserine hydrogen sulfide pgsA nucleoside triphosphate S-methyl-5'-thioadenosine nucleoside nucleoside lipoyl synthase: lipA glutamyltransferase: ggt KAB01_RS04400 KAB01_RS16000 a 5-methyluracil 1939 RS04415 (R)-2,3-dihydroxy- FabG: fabG 527 (4R)-4-hydroxy- dopamine synthase: leuC leuD prephenate 1-(3-sn- degradation IV phosphorylase: phosphorylase: L-alanyl-[S18 protein methylguanine a relaxed DNA cis-aconitate PLP RS09120 3-methylpentanoate decarboxylase: pyrophosphohydrolase: in 23S rRNA D-proline KAB01_RS02925 histidinol homoserine kinase: a (3R)-3- phosphatidyl) KAB01_RS01830 KAB01_RS01830 a 2'- of 30S ribosome] in 16S rRNA (2R,3S)-3- KAB01_RS12615 bifunctional prephenate mazG S-methyl-5'- a [DNA]-3'- ilvN dihydroxy-acid KAB01_RS17645 O-acetylhomoserine hydroxydodecanoyl-[acp] -sn-glycerol a [pyruvate dehydrogenase an α-(γ-L-glutamyl) an N-terminal ethanolamine sn-glycerol deoxyribonucleoside (R)-lactate glutathione histidinol isopropylmalate dUTP diphosphatase: dut thioadenosine 5'-deoxyadenosine leukotriene-D4 Arg hydroxyl (S)-2-aceto-2- dehydratase: aspartate/ dehydrogenase/3- sulfhydrylase: 5'-methylthioadenosine/ 2-deoxy-α-D- met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] -L-amino acid a tRNA arginyl-[protein] 3-phosphate 5'-monophosphate dehydrogenase: 3-isopropylmalate 3-hydroxyacyl- 3-phosphate dUTP dUMP hydroxybutanoate ilvD tyrosine/aromatic O-phospho- phosphoshikimate 1- KAB01_RS17545 S-adenosylhomocysteine ribose 1-phosphate RS09330 hisD dehydrogenase: aminotransferase: L-homoserine carboxyvinyltransferase: ACP dehydratase phosphatidylglycerophosphatase RS09185 ketol-acid (3S)-3-methyl-2- nucleosidase: leuB KAB01_RS00525 KAB01_RS12975 FabZ: fabZ A: KAB01_RS18450 reductoisomerase: histidinal oxopentanoate threonine 5-hydroxy-CTP 5-hydroxy-CMP KAB01_RS03955 α undecaprenyl-diphospho-N an N-terminal a 3,5,7,9,11,13,15- (2S)-2-isopropyl- 3-(4- L-homocysteine an L-1- UDP-N-acetyl- -D-glucosamine an L-arginyl- RNase R degradation ilvC branched-chain synthase: a (2E)-dodec-2-enoyl-[acp] MTR -acetylmuramoyl-L-alanyl-γ- a proteinogenic glutathione 3-sulfino-L- coenzyme A thr hepta-oxo- NaMN a uridine in tRNA reduced riboflavin asp D-serine CAIR hydroxyphenyl) phosphatidyl- Arg substrate RNA purine histidinol 3-oxosuccinate phe KAB01_RS01415 amino acid [tRNA ] FMN (R)-2,3-dihydroxy- amino acid pyruvate methionine methionine sn-glycerol D-glutamyl-L-lysyl- D-alanine alanyl-[protein] threonine ammonia- hexadecanoyl-[PKS-acp] bifunctional tRNA- 5-(carboxyamino) RS17195 RS12325 dehydrogenase: enoyl-ACP Detoxification aldo/keto reductase: msuE aspartate D-serine 3-methylpentanoate transaminase: bifunctional synthase: synthase: undecaprenyldiphospho- lyase, biosynthetic: ilvA metallophosphatase/ dihydrouridine xanthine imidazole hisD thr reductase: reductase: dehydrogenase: ammonia-lyase: dihydroxy-acid KAB01_RS16140 aspartate metH metH muramoylpentapeptide beta-N- ribonuclease CoA pyrophosphatase: 5'-nucleotidase: synthase: flavin reductase: dehydrogenase: ribonucleotide KAB01_RS02885 reactive oxygen species degradation gamma- arginyltransferase: R: rnr KAB01_RS03430 threonine ammonia- KAB01_RS17765 KAB01_RS09690 KAB01_RS04000 KAB01_RS03635 KAB01_RS05435 KAB01_RS05525 mutase: purE dehydratase: 4-methyl-2- transaminase/ arsenate arsenate acetylglucosaminyltransferase: 9-hydroxy-3,5,7,11,13,15- β xdhB xdhA his ile methionine methionine arsenate glutamyltransferase: ggt KAB01_RS04400 lyase: KAB01_RS15540 -D- a 5,6-dihydrouridine oxaloacetate pyruvate ilvD oxopentanoate aspartate 4- detoxification detoxification murG hexaoxohexadecanoyl- riboflavin 8-hydroxypurine AIR RS04460 synthase: synthase: a dodecanoyl-[acp] phosphatidylglycerol detoxification V 2-oxobutanoate ribosylnicotinate in tRNA RS04510 (3S)-3-methyl-2- branched-chain decarboxylase: KAB01_RS03630 KAB01_RS03630 superoxide II (glutaredoxin) III (thioredoxin) [PKS-acp] biosynthesis II (non-plastidic) ditrans,octacis-undecaprenyldiphospho- an N-terminal L- a nucleoside 5'- oxopentanoate amino acid KAB01_RS12615 arsenate UDP an α-(γ-L-glutamyl) a diribonucleotide 3',5'-ADP 4'-phosphopantetheine arsenate arsenate N-acetyl-(N-acetylglucosaminyl)muramoyl- L-cysteinylglycine a tRNA Arg arginiyl-3-sulfino- monophosphate transaminase: met beta-ketoacyl- Amine and Polyamine Degradation glyceraldehyde- -L-amino acid branched-chain aspartate/ DHAP arsenate reductase arsenate L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine L-alanyl-[protein] amino acid KAB01_RS16140 ACP synthase II: 3-phosphate RS09360 tyrosine/aromatic NAD(P)H- (glutaredoxin): arsC reductase RS14980 transaminase: aminotransferase: KAB01_RS04355 dependent glycerol- superpathway of urea degradation I hydrogen arsenate reductase: (glutaredoxin) dehydrogenase: leu laurate ethanolamine utilization 10 an N-terminal 1402 KAB01_RS16140 KAB01_RS00525 3-phosphate phenylethylamine peroxide KAB01_RS18180 : arsC KAB01_RS14250 an L-methionyl- an N - an L-arginyl- 3-(all-trans-heptaprenyl) a ribonucleoside a single a cytidine a double-stranded a [protein]-L- 5-hydroxy- 1-arseno-3- hypoglycin A glutathione 3-sulfo-L- D-cysteine uroporphyrinogen-I ω ser an aliphatic amine dehydrogenase: degradation arsenite arsenite Met formyltetrahydrofolate Arg benzene-1,2-diol triphosphate in 16S rRNA oligonucleotide proline ( = 180) hypoxanthine long-chain-fatty- phosphoglycerate [initiator tRNA ] [tRNA ] stranded DNA peptidylprolyl L-tryptophan ile tyr a 3-oxotetradecanoyl-[acp] KAB01_RS12895 ethanolamine urea catalase alanyl-[protein] bifunctional 3- 1-aminocyclopropane-1- 16S rRNA uroporphyrinogen primary- acid--CoA ligase: 2-phenylethylamine urea oligoribonuclease: isomerase: aromatic amino L-serine RS09420 sn-glycerol HPII: katE demethylubiquinone 3- carboxylate deaminase/D- (cytidine(1402)-2'-O) decarboxylase: xanthine amine RS04590 3-oxoacyl-ACP KAB01_RS10425 primary- carboxylase: orn KAB01_RS15775 acid lyase: ammonia-lyase: 3-phosphate ethanolamine [+ 2 isozymes] O-methyltransferase/2- DNA primase: cysteine desulfhydrase: -methyltransferase: KAB01_RS13465 dehydrogenase: oxidase: reductase [+ 3 isozymes] amine ammonia-lyase: uca H O hydroxyl radical methionyl-tRNA gamma- arginyltransferase: octaprenyl-6-hydroxy rsmI [+ 8 isozymes] KAB01_RS02795 KAB01_RS07390 tynA 2 1-arseno-3- KAB01_RS04235 KAB01_RS03910 a 2'-O- a nucleoside 5'- xdhB xdhA FabG: fabG glycerol-3- oxidase: urea-1-carboxylate formyltransferase: fmt glutamyltransferase: ggt KAB01_RS04400 coproporphyrinogen I a [protein]-L- KAB01_RS12085 arsenite arsenite phenol methylase: 1402 6,8- serotonin pyruvate an aldehyde lauroyl-CoA phosphate 1-O- tynA O phosphoglycerate pyruvate methylcytidine monophosphate proline (ω = 0) 3-oxoacyl-ACP eutC 2 KAB01_RS00330 dihydroxypurine RS04575 acyltransferase phenylacetaldehyde allophanate in 16S rRNA RS09515 reductase an N-formyl- an N-terminal L- 2-methoxy-6-(all-trans ssDNA/pppN(pN) PlsB: plsB acetaldehyde hydrolase: FabG: fabG phenylacetaldehyde L-methionyl- a tetrahydrofolate hypoglycin B L-cysteinylglycine a tRNA Arg arginiyl-3-sulfo- -heptaprenyl)phenol hybrid peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis a 1-acyl-sn atzF n -1 lipid IV biosynthesis (P. putida) met L-alanyl-[protein] A lipid IV biosynthesis (E. coli) peptidoglycan maturation (meso-diaminopimelate containing) -glycerol 3- dehydrogenase: [initiator tRNA ] A a (3R)-3- C1 Compound Utilization and Assimilation RS09495 UDP-N-acetyl-α-D-glucosamine phosphate KAB01_RS10535 carbamate a (3R)-3- a (3R)-3- lipid II (meso hydroxytetradecanoyl-[acp] RS17485 1-acyl-sn-glycerol- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- an N-terminal L- all-trans- D-threo-7,8- α-D-mannose a 23S rRNA a cytidine 1402 dimethyl(3- UDP-N-acetylglucosamine hydroxydecanoyl- UDP-N-acetyl- hydroxytetradecanoyl- UDP-N-acetyl- diaminopimelate containing) 3-hydroxyacyl- phenylacetate formaldehyde oxidation an L-arginyl- 2-hydroxyisobutyramide 3-methylmuconolactone (E)-caffeoyl-CoA acetamide glyoxal 3-phosphate choline degradation I formaldehyde oxidation alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine decaprenyl 1911/1915/1917 Ins(1)P oxopropyl) 1-carboxyvinyltransferase: [acp] α-D-glucosamine α ACP dehydratase VII (THF pathway) aspartyl-[protein] [tRNA Arg ] 4-hydroxybenzoate dihydroneopterin 1-phosphate uridine in 16S rRNA met met [acp] -D-glucosamine monofunctional acyltransferase: acetyl-CoA ethanol II (glutathione-dependent) diphosphate phosphomannomutase/ 23S rRNA 16S rRNA electron transfer sulfanium isoprenoid RS18780 murA biosynthetic FabZ: fabZ phenylacetate-- undecaprenyldiphospho- muconolactone inositol betaine-aldehyde ala ala acyl-ACP--UDP-N- KAB01_RS16330 phosphoglucomutase: pseudouridine(1911/ (cytosine(1402)-N(4) amidase: Delta- flavoprotein amidase: biosynthesis UDP-N-acetyl-α-D- acyl-ACP--UDP-N- peptidoglycan CoA ligase: paaF phosphate CO choline formaldehyde muramoylpentapeptide beta-N- monophosphatase: dehydrogenase: choline RS05310 choline acetylglucosamine O- [+ 2 isozymes] 2 formaldehyde arginyltransferase: 4-hydroxybenzoate dihydroneopterin KAB01_RS00500 1915/1917) )-methyltransferase KAB01_RS10595 isomerase: catC subunit alpha: KAB01_RS10595 glyoxalase asp asp glucosamine-enolpyruvate acetylglucosamine O- transglycosylase: a (2E)-tetradec-2-enoyl-[acp] a 1,2-diacyl- acetyltransferase: pta choline acetylglucosaminyltransferase: KAB01_RS16935 betB aldolase: folB phosphomannomutase/ synthase RluD: rluD 4 RsmH: rsmH KAB01_RS14700 ElbB: elbB acyltransferase: lpxA phenylacetyl-CoA dehydrogenase: Carbohydrate Degradation murG KAB01_RS04400 octaprenyltransferase: 1911/ an N - 2-hydroxy-2- 4-methyl-3-oxoadipate- AspT glu acyltransferase: lpxA mtgA sn-glycerol a pseudouridine myo-inositol acetate UDP-N-acetylmuramate enoyl-ACP betA a 5,10- ubiA phosphoglucomutase: 1402 methylpropanoate enol-lactone hydrocaffeoyl-CoA DMSP glycolate a nascent peptidoglycan 3-phosphate acetyl phosphate S-(hydroxymethyl) 1915/1917 in 23S rRNA methylcytidine RS17610 ala ala glutamate ala dehydrogenase: murB UDP-3-O-[(3R)-3- UDP-3-O-[(3R)-3- reductase: phenylacetate- betaine aldehyde methylenetetrahydrofolate an N-terminal KAB01_RS04485 in 16S rRNA RS12575 hydroxydecanoyl]- with (L-alanyl-γ-D-glutamyl- phosphatidate CoA oxygenase/ D-galactose degradation I (Leloir pathway) Entner-Doudoroff shunt glutathione ditrans,octacis-undecaprenyldiphospho-N- UDP 6-(hydroxymethyl) glycolaldehyde D-mannopyranose racemase: murI UDP-N-acetyl-α-D-muramate hydroxymyristoyl]-N- KAB01_RS02885 allantoin degradation bifunctional a tRNA Arg L-arginiyl-L- α meso-2,6-diaminopimeloyl-D- cytidylyltransferase: acetate kinase: glutathione- acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- 3-decaprenyl-4- -7,8-dihydropterin 6-phosphate N-acetyl- -D- acetyl-α-D-glucosamine reductase: to glyoxylate I betaine-aldehyde β methylenetetrahydrofolate glutamate alanyl-D-alanine) pentapeptide KAB01_RS11180 KAB01_RS02630 -D- dependent alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine aspartyl-[protein] hydroxybenzoate UDP-N-acetylmuramate- glucosamine UDP-3-O-acyl-N- a myristoyl-[acp] paaA paaB dehydrogenase: D-gluconate dehydrogenase/ racemase: murI galactopyranose formaldehyde -L-alanine ligase: murC UDP-3-O-acyl-N- acetylglucosamine a CDP- paaC paaJ paaK (S)-(+)-allantoin betB 6-phosphate methenyltetrahydrofolate AqpZ D-alanyl-D-alanine D-alanyl-D-alanine fatty acid elongation -- saturated acetate dehydrogenase: RS12600 acetylglucosamine deacetylase: beta-ketoacyl- diacylglycerol 2-(1,2-epoxy-1,2- allantoinase phosphogluconate cyclohydrolase FolD: folD all-trans- DNA combined with 6-O-cis-keto- D-glt glycine betaine an N-terminal L- an L-arginyl- S-(2-hydroxyacyl) UDP-4-amino-D-fucose 54 propane- α deacetylase: endopeptidase endopeptidase ACP synthase II: CDP-diacylglycerol-- dihydrophenyl) dehydratase: KAB01_RS07095 dethiobiotin a sulfurated 4-hydroxybenzoate an adenine in DNA a uracil in tRNA Ins(2)P mycolyl-trehalose (S)-malate UDP-N-acetyl- -D-muramoyl-L-alanine KAB01_RS18120 PuuE: puuE SAM glutamyl-[protein] Arg hexaprenyl exogenous DNA to form glutathione acyl-carrier protein 1,3-diamine PBP7/8: pbpG PBP7/8: pbpG a mature peptidoglycan with acetyl-CoA α-D- a 5,10- [sulfur carrier] [tRNA ] 4-hydroxybenzoate UDP-4-amino-4, 6- KAB01_RS18120 UDP-3-O-(3- KAB01_RS04355 glycerol-3-phosphate 3- an acetoacetyl-[acp] allantoate KAB01_RS02645 S-(hydroxymethyl) diphosphate a recombinational junction 4-hydroxybenzoate DNA adenine tRNA 6-phosphate malate primary- UDP-3-O-(3- [+ 3 isozymes] [+ 3 isozymes] (L-alanyl-γ-D-glutamyl-meso- galactopyranose methenyltetrahydrofolate Holliday junction dideoxy-N-acetyl- ACP S- inositol trehalose- UDP-N-acetylmuramoyl- hydroxymyristoyl) phosphatidyltransferase: 2-(1,2-epoxy-1,2- glutathione 3-monooxygenase: methylase: (uridine(54)-C5)- dehydrogenase amine hydroxydecanoyl) α 2,6-diaminopimeloyl-D-alanyl- a 3-oxohexadecanoyl-[acp] bifunctional resolvase RuvX: ruvX beta-L-altrosamine malonyltransferase: monophosphatase: phosphatase: AdeS RS09820 L-alanine--D-glutamate - -D-glucosamine pgsA dihydrophenyl) allantoicase: KDGP dehydrogenase/ biotin arginyltransferase: 4-hydroxybenzoate hydroxyacylglutathione pobA KAB01_RS01345 methyltransferase (quinone): mqo oxidase: -α-D-glucosamine a nascent peptidoglycan a nascent peptidoglycan D-alanine) pentapeptide putrescine degradation II methylenetetrahydrofolate crossover junction transaminase: pseC fabD KAB01_RS16935 otsB ligase: KAB01_RS01450 UDP-3-O-(3- 1-(3-sn- acetyl-CoA class III alcohol synthase hydrolase: gloB 6 TrmA: trmA tynA with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- KAB01_RS18250 urea degradation II KAB01_RS04400 octaprenyltransferase: endodeoxyribonuclease UDP-4-dehydro-6- an N -methyladenine 54 UDP-3-O-(3- hydroxymyristoyl) 3-oxoacyl-ACP phosphatidyl) isomerase: α dehydrogenase/ protocatechuate a 5-methyluracil trehalose-cis-keto- oxaloacetate -D-galactose dehydrogenase: BioB: bioB ubiA α in DNA myo-inositol 3-aminopropanal meso-diaminopimelate UDP-N-acetyl-α-D-muramoyl- hydroxymyristoyl) glucosamine N- meso-2,6-diaminopimeloyl- diaminopimelate containing) reductase -sn-glycerol KAB01_RS07430 UDP-α-D-glucose bifunctional methenyltetrahydrofolate resolution of recombinationalRuvC: ruvC deoxy- -D-glucose a malonyl-[acp] in tRNA mono-mycolate D-alanine) tetrapeptide putrescine (S)-ureidoglycolate 1-phosphate KAB01_RS09765 an N-terminal RS17795 L-alanyl-D-glutamate glucosamine N- acyltransferase: FabG: fabG 3-phosphate a 3-oxoacyl-[acp] 2-oxepin-2(3H)- gamma- urea 4-hydroxy-2- cyclohydrolase FolD: folD junction formation a 2-hydroxy RS09905 3-oxoacyl- biotin 5'-deoxyadenosine an unsulfurated a tRNA Arg L-arginiyl-L- glutathione acyltransferase: lpxD 3-oxoacyl-ACP ureidoglycolate : ureA oxoglutarate an N 10 - S-formylglutathione met 3-hexaprenyl-4- of two intact strands carboxylate L,D-transpeptidase: L,D-transpeptidase: phosphatidylglycerophosphatase ACP ylideneacetyl-CoA glutamylputrescine [sulfur carrier] glutamyl-[protein] UDP-N-acetylmuramoyl- D-ala lpxD UDP-2-N,3-O-bis[(3R)- a mature peptidoglycan reductase synthetase: lyase: KAB01_RS05730 aldolase/2- formyltetrahydrofolate hydroxybenzoate UDP-2-N-[(3R)-3- KAB01_RS15620 KAB01_RS15620 A: KAB01_RS18450 reductase oxepin-CoA L-alanyl-D-glutamate-- 3-hydroxytetradecanoyl]- with D,D cross-links (meso- FabG: fabG KAB01_RS12245 KAB01_RS18255 ammonium dehydro-3-deoxy- S-formylglutathione hydroxydodecanoyl]- α a nascent peptidoglycan with a mature peptidoglycan an L-1- FabG: fabG hydrolase: γ-glutamyl- formyltetrahydrofolate RS09980 2, 6-diaminopimelate D-alanine--D-alanine -D-glucosamine a nascent peptidoglycan a nascent peptidoglycan diaminopimelate containing) UDP- phosphogluconate hydrolase: fghA RS17805 3-O-[(3R)-3- (L-alanyl-γ-D-glutamyl-meso- with (L-alanyl-γ-D-glutamyl- a (3R)-3- phosphatidyl- 3-oxoacyl- paaZ L-putrescine glyoxylate deformylase: purU an L-1- an (S-diacyl-sn- a single- N,N',N''- adenine 1518 / a 5' triphospho- (2R,3S)-3- ligase: KAB01_RS17415 ligase: KAB01_RS18140 UDP-2,3- γ glucose 4- aldolase: eda glycyl-glycine glutathione wound RNA oxaloacetate 2-phosphoglycolate propionamide Fe 2+ a primary amine with L,D cross links (meso- 2,6-diaminopimelate) tripeptide with (L-alanyl- -D-glutamyl- meso-2,6-diaminopimeloyl- hydroxyhexadecanoyl-[acp] sn-glycerol 3-oxo-5,6- glyceryl)-L-cysteinyl- triacetylchitotriose 1519 L-ornithine hydroxydecanoyl]- diacylglucosamine ACP epimerase formate phosphatidylethanolamine stranded RNA adenine in 16S rRNA [mRNA] isopropylmalate α α diaminopimelate containing) meso-2,6-diaminopimeloyl- D-alanine) tetrapeptide beta-ketoacyl- didehydrosuberyl- formate [apolipoprotein] 16S rRNA ATP-dependent RNA primary- UDP-N-acetyl- -D-muramoyl-L-alanyl- D-alanyl-D-alanine -D-glucosamine diphosphatase: 3-hydroxyacyl- reductase GalE: galE D-glyceraldehyde RNA phosphoenolpyruvate phosphoglycolate 3-isopropylmalate γ glycine) tetrapeptide ACP synthase II: CoA semialdehyde (adenine(1518)-N(6)/ helicase RhlB: rhlB arginine N- amidase: bacterioferritin: bfr amine -D-glutamyl-meso-2,6-diaminopimelate UDP-2,3- ACP dehydratase FabG: fabG γ 3-phosphate pyruvate beta-N- pyrophosphohydrolase: carboxykinase (GTP) phosphatase: dehydratase: RS17915 KAB01_RS12110 KAB01_RS04355 a (3R)-3- 3-oxo-5,6- 4-( -L- gamma- polyribonucleotide adenine(1519)-N(6))- ATP-dependent RNA succinyltransferase: KAB01_RS10595 bacterioferritin: bfr oxidase: RS00125 diacylglucosamine a mature peptidoglycan with FabZ: fabZ a 2,3,4-saturated glutamylamino) apolipoprotein N- acetylhexosaminidase: KAB01_RS02260 : KAB01_RS14910 KAB01_RS01580 leuC leuD UDP-N-acetylmuramoyl- a mature peptidoglycan hydroxyacyl-[acyl- dehydrosuberyl- glutamyltransferase: ggt nucleotidyltransferase: pnp dimethyltransferase helicase HrpA: hrpA astA tynA diphosphatase: lipid X (L-alanyl-γ-D-glutamyl-meso- acyltransferase: lnt nagZ a 5'-phospho- phosphoenol 2 (2S)-2- fatty acyl-[acp] CoA semialdehyde butanal glycolate N -succinyl- propanoate Fe 3+ tripeptide--D-alanyl-D- with L,D cross-links (meso- a mature peptidoglycan a (2E)-hexadec-2-enoyl-[acp] 3-hydroxyacyl-carrier protein] γ γ α-D- Degradation/Utilization/Assimilation - Other 6 RsmA: rsmA1518 [mRNA] an unwound RNA pyruvate isopropylmalate an aldehyde KAB01_RS12110 lipid-A- 2,6-diaminopimelate) tripeptide dehydrogenase: -glutamyl- - UDP-α-D- N -dimethyladenine L-ornithine alanine ligase: murF diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- ACP 6 1519 RS17960 aminobutyraldehyde glucopyranose a 2-acyl-1-lyso- an N-acyl-(S-diacyl- γ-L-glutamyl- a single- N,N'- N-acetyl-D- /N -dimethyladenine lipid X (P. putida) disaccharide meso-2,6-diaminopimeloyl- enoyl-ACP dehydratase paaZ galactose L-cysteinylglycine a nucleoside RS12870 α 3-oxo-5,6- dehydrogenase: betB 1-phosphate octane oxidation phosphatidylethanolamine sn-glyceryl)-L- glycylglycine stranded RNA diacetylchitobiose glucosamine in 16S rRNA UDP-N-acetyl- -D-muramoyl-L- synthase: lpxB glycine) tetrapeptide reductase: FabZ: fabZ 4-(γ-L- acrylonitrile diphosphate γ lipid-A- didehydrosuberyl- cysteinyl-[lipoprotein] alanyl- -D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate lipid A disaccharide KAB01_RS02885 glutamylamino) phosphomannomutase/ degradation I diaminopimeloyl-D-alanyl-D-alanine disaccharide (E. coli) CoA phosphoglucomutase: NADH Kdo transfer to 3-oxo-5,6- butanoate fructose degradation α RS05250 synthase: lpxB tetraacyldisaccharide a palmitoyl-[acp] KAB01_RS04485 acrylonitrile a [protein]-N 6 - an [amino-group carrier protein]- a cytosine 967 a uridine 55 (R)-3- a monocarboxylic 6-O- -mycolyl- lipid IV I (E. coli) NAD + UDP-N-acetyl-α-D-muramoyl- phylloquinone NAD(P)H H + 1-aminocyclopropane- RS17965 phospho-N- lipid A A dehydrosuberyl- D-alanyl-D-alanine C-terminal-γ-(L-glutamate 5- uroporphyrinogen-III D-glycerate meso-tartrate NADH trehalose 6- 4'-kinase: phosphomannomutase/ β acetyl-L-lysine L-alanyl-γ-D-glutamyl-L-lysine in 16S rRNA in tRNA hydroxybutanoate acid amide acetylmuramoyl- disaccharide a trans-2- CoA L-carnitine degradation III -D-fructofuranose semialdehyde-2-yl)-L-glutamate 1-carboxylate phosphate KAB01_RS08730 CMP-Kdo lipid IV (E. coli) a 2,3,4-saturated enoyl-ACP phosphoglucomutase: N-acetyl-gamma- 1-aminocyclopropane- uroporphyrinogen-III 16S rRNA tRNA 3-hydroxybutyrate D-glycerate tartrate NAD(+)/ pentapeptide- A enoyl-[acyl- thiolase: pcaF 1-phosphate amidase: trehalose- (P. putida) fatty acyl-[acp] reductase: 1-phosphofructokinase: acrylamide glutamyl-phosphate C-methyltransferase: (cytosine(967)-C(5) pseudouridine(55) dehydrogenase: dehydrogenase: dehydrogenase: NADH kinase: transferase: lipid IV (E. coli) carrier protein] 4-aminobutanoate KAB01_RS00500 a reduced NAD-dependent UDP-N-acetylmuramoyl- NAD(P)H:quinone 1-carboxylate KAB01_RS10595 phosphatase: RS10165 tetraacyldisaccharide A KAB01_RS02885 trans-2,3- L-carnitine pfkB octane reductase: cobA )-methyltransferase synthase TruB: truB KAB01_RS09585 KAB01_RS12850 KAB01_RS04295 KAB01_RS14905 KAB01_RS17405 3-deoxy-D-manno- D-glucopyranose β-D-fructose 1,6- rubredoxin deacylase: tripeptide--D-alanyl-D- oxidoreductase: deaminase/D-cysteine otsB RS10125 4'-kinase: palmitate dehydroadipyl-coA amidase: KAB01_RS10825 RsmB: rsmB 55 KAB01_RS08590 wrbA an [amino-group carrier protein]- desulfhydrase: 967 a pseudouridine 2-hydroxy-3- α α KAB01_RS08730 octulosonic acid 6-phosphate bisphosphate alanine ligase: murF precorrin-2 a 5-methylcytosine acetoacetate a monocarboxylate hydroxypyruvate NADPH , '-trehalose enoyl-CoA carnitine KAB01_RS10595 C-terminal-γ-(5-phospho- KAB01_RS03910 in tRNA oxosuccinate α undecaprenyldiphospho- lipid IV transferase: long-chain-fatty- enoyl-ACP alkane 1- in 16S rRNA 6- -mycolate A hydratase: monooxygenase: L-glutamyl)-L-glutamate 2-oxobutanoate RS10195 N-acetylmuramoyl-L-alanyl- (P. putida) KAB01_RS18020 acid--CoA ligase: reductase: monooxygenase: acrylate 2''-O-acetyl- UDP-N-acetyl-α-D-muramoyl-L-alanyl- γ KAB01_RS00670 KAB01_RS04320 nicotinamide a [protein]-L-lysine NAD(P) + phylloquinol -D-glutamyl-meso-2,6- KAB01_RS01125 KAB01_RS02885 (3S)- KAB01_RS09040 ADP-ribose γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine RS05305 α diaminopimeloyl-D-alanyl-D-alanine -Kdo-(2->6)- [+ 3 isozymes] hydroxyadipyl- lipid IV (E. coli) L-malic H + RS02480 H + undecaprenyldiphospho- A CoA trimethylamine octan-1-ol 6 palmitoyl-CoA semialdehyde 3-methyl-2- 5,10-methylene- an N -L- 1915 UDP-4-amino-4-deoxy- dCTP muramoylpentapeptide beta-N- KDO transferase: 3-hydroxyacyl-CoA + a pseudouridine 3-phenyl-2- threonylcarbamoyladenine 37 NAD(P)H a plastoquinone H β-L-arabinopyranose malonate 4-guanidinobutyramide N-ethylmaleimide oxaloacetate D-glycerate L-tartrate 7,8-dihydropterin acetylglucosaminyltransferase: KAB01_RS18020 dehydrogenase: aldehyde oxobutanoate tetrahydromethanopterin in 23S rRNA oxopropanoate + + RS18095 in tRNA 23S rRNA UDP-4-amino-4, 6- biotin-independent dCTP deaminase: H RS08715 H murG α-Kdo-(2->4)- KAB01_RS07435 dehydrogenase D-glycerate tartrate guanine tRNA (pseudouridine(1915)- 4-hydroxyphenylpyruvate dideoxy-N-acetyl- malonate decarboxylase: amidase: alkene reductase: 2-methylcitrate KAB01_RS03970 α-Kdo-(2->6)- (NADP(+)): 3-methyl-2-oxobutanoate NAD(P)H:quinone dehydrogenase: dehydrogenase: deaminase: lipid II (meso diaminopimelate containing) threonylcarbamoyladenosine N(3))-methyltransferase dioxygenase: hppD beta-L-altrosamine mdcA KAB01_RS08030 KAB01_RS10595 KAB01_RS18025 synthase: prpC + + lipid IV (E. coli) 3-oxoadipyl-CoA KAB01_RS07380 1-octanal hydroxymethyltransferase: oxidoreductase: KAB01_RS12850 KAB01_RS04295 guaD H RS08870 H A dehydratase: KAB01_RS02990 transaminase: pseC dUTP panB a cyclic N 6 -L- 3 RlmH: rlmH (2-hydroxyphenyl) β mdcE mdcH 1,2-dihydroxypropane- 2-hydroxy-3- 7,8- [+ 2 isozymes] wrbA an N - UDP- -L-threo- 4-guanidinobutanoate N-ethylsuccinimide hydroxypyruvate RS05415 3-oxoadipyl- 1915 acetate threonylcarbamoyladenosine methylpseudouridine acetate pentapyranos-4-ulose 1,2,3-tricarboxylate oxosuccinate dihydrolumazine F0F1 ATP CoA (S)-malate 37 in tRNA in 23S rRNA H + H + thiolase: synthase 2-dehydropantoate THMPT a plastoquinol NAD(P) + pcaF octanoate RodA [+ 3 isozymes] long-chain-fatty- RS00550 succinyl-CoA pyruvate acid--CoA ligase: 2,5-diamino-6-(5- phosphatidylglycerolphosphate a double a 5-carboxymethylaminomethyluridine 34 UDP-2-acetamido-4-amino- N,N'- uridine 2605 UDP-N-acetyl- (2R,3S)-3- 6,8- CTP α a cytosine in DNA α D-glycerate phospho-D-ribitylamino) stranded DNA in tRNA Leu 2,4,6-trideoxy- -D-galactose diacetylchitobiose in 23S rRNA -D-glucosamine isopropylmalate dihydroxypurine KAB01_RS10425 (1-oleoyl, 2-palmitoyl) UDP-4-amino-4, 6- UDP-N- pyrimidin-4(3H)-one tRNA (cytidine(34) beta-N- 23S rRNA DNA cytosine 3-isopropylmalate xanthine dCTP deaminase: [+ 3 isozymes] bifunctional exodeoxyribonuclease dideoxy-N-acetyl- acetylglucosamine glycerate kinase: RS05585 phosphatidylglycerophosphatase -2'-O)- acetylhexosaminidase: pseudouridine(2605) methyltransferase: dehydrogenase: dehydrogenase: KAB01_RS03970 diaminohydroxyphosphoribosylaminopyrimidine V: KAB01_RS01990 recD beta-L-altrosamine 2-epimerase (non- KAB01_RS14775 RS05595 octanoyl-CoA A: KAB01_RS18450 methyltransferase: nagZ synthase RluB: rluB KAB01_RS04745 leuB xdhB xdhA deaminase/5-amino-6-(5-phosphoribosylamino) transaminase: pseC hydrolyzing): wecB UTP KAB01_RS15195 N-acetyl-D- 2605 α uracil reductase RibD: ribD 1-oleoyl-2-palmitoyl- a 5'-phosphooligonucleotide a 5-carboxymethylaminomethyl- UDP-2-acetamido-2,6- a pseudouridine a 5-methylcytosine UDP-N-acetyl- - 4-methyl-2- urate 2-phospho- 5-amino-6-(5-phospho- α glucosamine phosphatidylglycerol 34 Leu dideoxy- -D-xylo-hex-4-ulose in 23S rRNA in DNA D-mannosamine oxopentanoate D-glycerate D-ribitylamino)uracil 2'-O-methyluridine in tRNA

LolD an amino an amino RS18570 a dicarboxylate a dicarboxylate a dicarboxylate a dicarboxylate acinetobactin a sulfonate phosphate acid acid a quaternary tetracycline a branched- Fe 3+ lipid II (meso ammonium a peptide a nicotinamide glutamate a C4- chain an aromatic uracil an inorganic an inorganic an inorganic an aliphatic an aliphatic an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino TET microcin C xanthine (S)-lactate ethanolamine chromate chromate chromate a lipopolysaccharide a lipopolysaccharide L-carnitine choline ammonium ammonium phosphate arsenite benzoate benzoate acid acid an amino acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid malonate malonate an aromatic diaminopimelate compound antibiotic pyrimidine mononucleotide fosfomycin chlorhexidine dicarboxylate amino acid carboxylate anion anion anion sulfonate sulfonate phosphate containing) a polysaccharide a lipopolysaccharide acid amino acid predicted predicted predicted predicted predicted ABC predicted ABC predicted ABC ABC ABC ABC ABC transporter RS05590 RS05315 RS05260 RS10085 FtsW AdeF RS05060 RS17690 RS17570 RS09500 RS17230 RS17175 YccS RS09215 RS12285 RS09110 RS09030 RS08900 RS08860 RS16655 RS03890 TraL RS03765 RS19210 RS16320 TcuB RS03495 RS03450 RS03270 RS15915 RS15840 RS00410 SbmA RS18745 RS05370 RS01275 GltS YejB AbaF AceI DctA BrnQ RS06665 RS15795 LldP Eat RS11065 RS17555 RS01225 RS12320 SsuC RS08185 ChrA RS08190 efflux transporter of efflux transporter of LptA RS04300 RS05520 BetT RS15315 RS01330 RS13955 RS10210 ArsB BenE BenE RS14735 RS11080 RS06255 RS13975 RS13775 RS18530 RS18490 RS00640 RS00635 RS12995 RS05270 RS15385 RS15805 RS08230 transporter transporter RS16850 RS17085 RS17460 RS12550 RS12770 RS17870 RS13095 MadL MadM RS09450 FtsI RS12605 RS17775 RS17885 RS12880 RS13165 YddG RS00785 RS05550 RS13300 RS13345 RS18415 RS13350 RS06780 RS00680 RS05685 RS05695 RS00740 RS00765 RS18515 RS13460 RS05755 RS00780 RS16215 RS10605 transporter transporter of Fe3+/ a lipopolysaccharide a lipopolysaccharide of an of an of a sulfonate of phosphate acinetobactin amino acid amino acid a quaternary a peptide pyrimidine a nicotinamide a C4- a branched- an aromatic an inorganic an inorganic an inorganic an aliphatic an aliphatic lipid II (meso microcin C (S)-lactate ethanolamine chromate chromate chromate L-carnitine choline ammonium ammonium phosphate arsenite benzoate benzoate an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino malonate malonate ammonium a polysaccharide antibiotic mononucleotide glutamate dicarboxylate chain carboxylate anion anion anion sulfonate sulfonate a lipopolysaccharide an amino an amino an amino an amino an amino an aromatic diaminopimelate TET fosfomycin chlorhexidine xanthine phosphate acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acinetobactin a sulfonate compound amino acid uracil a lipopolysaccharide a lipopolysaccharide phosphate acid acid acid acid acid amino acid containing) tetracycline an amino an amino Fe 3+ a dicarboxylate a dicarboxylate acid acid a dicarboxylate a dicarboxylate This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.