Nanoparticles for Pest Control: Current Status and Future Perspectives
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J Pest Sci (2018) 91:1–15 https://doi.org/10.1007/s10340-017-0898-0 REVIEW Nanoparticles for pest control: current status and future perspectives 1 2 3,7 4 C. G. Athanassiou • N. G. Kavallieratos • G. Benelli • D. Losic • 5 6 P. Usha Rani • N. Desneux Received: 3 October 2016 / Revised: 19 June 2017 / Accepted: 21 June 2017 / Published online: 21 August 2017 Ó Springer-Verlag GmbH Germany 2017 Abstract In the current paper, we reviewed the use of agents. Finally, the potentials in the use of NPs are briefly nanoparticles (NPs) in crop protection, emphasizing the illustrated and discussed. control of pests in the agricultural and urban environment. At the same time, we provide the framework on which the Keywords Nanotechnology Á Green synthesis Á technology of NPs is based and the various categories of Nanopesticides Á Nanotoxicity Á Nanoencapsulation Á NPs that are currently used for pest control. Apart from the Nanoinsecticides use of NPs as carriers of a broad category of active ingredients, including insecticides and pheromones, some Key message NPs can be used successfully as insecticides alone. More- over, several types of NPs are produced by natural • There is a knowledge gap on the use of nanoparticles in resource-based substances, which make them promising pest control. ‘‘green’’ alternatives to the use of traditional pest control • We reviewed the use of nanoparticles for insect control and the different categories of pests that can be controlled. Communicated by M. Traugott. • Nanoparticles should become important components in an IPM-based strategy in the agro-food and urban & C. G. Athanassiou [email protected] environment. 1 Laboratory of Entomology and Agricultural Zoology, Department of Agriculture, Crop Production and Rural Introduction Environment, University of Thessaly, Phytokou Str., 38446 N. Ionia, Magnesia, Greece Despite the fact that there are several available alternative 2 Laboratory of Agricultural Zoology and Entomology, Department of Crop Science, Agricultural University of methods, pest control is still largely based on the use of pes- Athens, 75 Iera Odos Str., 11855 Athens, Attica, Greece ticides, in the sense of organic chemical-based ingredients that 3 Department of Agriculture, Food and Environment, are applied on the crops, the commodity, or the urban envi- University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy ronment. Even today, many of the registered pesticides are 4 neurotoxic, which means that their primary mode of action School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia interferes with the insects’ nervous system and may pose risks of mammals. Newer compounds, such as the insecticides that 5 Biology and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India are adenosine triphosphate (ATP) disruptors or insect growth regulators (IGRs), have been introduced recently in the mar- 6 INRA (French National Institute for Agricultural Research), Universite´ Coˆte d’Azur, CNRS, UMR 1355-7254, Institut ket and have gradually reduced the use of neurotoxic com- Sophia Agrobiotech, 06903 Sophia Antipolis, France pounds, but there are still concerns about their environmental 7 The BioRobotics Institute, Scuola Superiore Sant’Anna, impact. In this regard, pesticide use has been related with Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy mammalian toxicity, environmental contamination, and 123 2 J Pest Sci (2018) 91:1–15 bioaccumulation. These variables, along with the increased relevant for their use in pesticide application, including toxi- frequency of resistance development by many insect species city. A broad variety of materials were synthesized or used to many of the currently used compounds, are major key from natural materials to make NPs in different forms and challenges in agriculture, and may considerably limit the chemical composition including metal, metal oxides, semi- active ingredients that are effective. To address these prob- conductor quantum dots (QDs), carbon, ceramics, silicates, lems, new pest control strategies are required through intro- lipids, polymers, proteins, dendrimers, and emulsions (Nie- duction of innovative pest-resistive concepts and advanced meyer and Doz 2001;Oskam2006;Puocietal.2008). Some technologies for pest management. common benefits of NP-based pesticide formulations include: Nanotechnology is emerging as a highly attractive research (a) increased solubility of water insoluble active ingredients, field toward achieving these goals, offering new methods for (b) increased stability of formulation, (c) elimination of toxic designing novel active ingredients with nanoscale dimen- organic solvents in comparison with conventionally used sions, as well as their formulation and delivery, which are pesticides, (d) capability for slow release of active ingredients, collectively referred to as ‘‘nanopesticides.’’ Nanopesticide (e) improved stability to prevent their early degradation, research, introduced relatively recently, is an emerging field (f) improved mobility and higher insecticidal activity due to that can be defined as application of nanotechnology for crop smaller particle size, and (g) larger surface area which is likely protection. This field compromises broad research aspects to extend their longevity (Sasson et al. 2007). including study of fundamental understanding of interaction This review presents the recent advances in the devel- of nanoscale materials and insects, formulation of the active opment of NP-based formulations on the basis of three ingredients into nanoemulsions and dispersions using existing major concepts: the improvement of conventional pesticide pesticides, development of new nanopesticide formulations formulations, the development of delivery systems and the using nanomaterials as active pesticide agents, or using these use of NPs as nanocarriers, and solid NPs used as active nanomaterials as nanocarriers for their delivery (Smith et al. pesticide agents. 2008; Yasur and Usha Rani 2013; Benelli et al. 2017). This broad nanopesticide research is expected to address the main limitations of the existing pest control strategies and provides Nanoparticles to improve pesticide formulations new advanced nano-based formulations that remain stable and active in the target environment (i.e., not heavily affected by Recently, a number of plant-synthesized NPs have been sun, heat, and rain), penetrate the target organism (insect), investigated for their efficacy against arthropod pests of resist defense of the pest, remain benign to plants and mam- economic importance, including moths (Roni et al. 2015), mals, be cost effective to formulate and manufacture, and beetles (Abduz Zahir et al. 2012), lice (e.g., Pediculus preferably possess a new mode of action (Smith et al. 2008; humanus capitis) (Jayaseelan et al. 2011), hard ticks (e.g., Benelli 2016a, b). Haemaphysalis bispinosa) (Abduz Zahir and Abdul Rahuman 2012), louse flies (e.g., Hippobosca maculata) (Jayaseelan et al. 2012), and mosquitoes (Benelli 2016a, b). Nanoparticles for pest control: definition, concepts, However, not surprisingly, the majority of research dealing and perspectives with nanosynthesis of insecticides focused on mosquito control. More than 100 research products were found in the Nanoparticles (NPs) can be defined as a subclass of ultrafine SCOPUS database using the keywords ‘‘plant nanoparticles particles with characteristic dimensions from 1 to 100 nm and mosquitoes’’ (Benelli 2016a). have properties that are not shared by non-nanoscale particles Most of currently used pesticides are poorly water sol- with the same chemical composition (Auffan et al. 2009). The uble molecules, and their formulations are based on basis of the 100-nm limit is the fact that unique properties that emulsifiable concentrates (ECs), oil-in-water (O/W) differentiate particles from the bulk material typically develop emulsions, or similar formulations that are variations of the at a critical size of under 100 nm. However, because other above (Knowles 2009). ECs usually consist of organic phenomena (e.g., transparency or turbidity, ultrafiltration, solvents that are expensive, flammable, and toxic, or a stable dispersion) that extend the upper limit are occasionally blend of surfactant emulsifiers to ensure spontaneous considered, the use of the prefix ‘‘nano’’ (‘‘ma9mo’’ in Greek, emulsification into water in the spray tank. O/W emulsions meaning small, dwarf) is accepted for dimensions smaller than do not have these shortcomings because they are based on 500 nm (Alema´netal.2007). The size, shape (spherical, rods, the removal of solvent and the introduction of a mixture of tubes, irregular), surface-to-volume ratio, crystal phase (crys- a non-ionic surfactant, block polymers, and polymeric talline, amorphous), and chemical composition (e.g., metallic, surfactants; nevertheless, one of the major drawbacks in carbon, inorganic, organic, polymeric) are key parameters their use is the fact that emulsification requires high-energy which define many outstanding properties of these materials input (Kah et al. 2013; Kah and Hofmann 2014). 123 J Pest Sci (2018) 91:1–15 3 To address these disadvantages, new formulations based et al. 2011). Plant cell walls have the remarkable capability on micro- and nanoemulsions were introduced with the of impeding the entry of NPs. In spite of this doubtful capability to provide NPs in sizes from 20 to 100 nm impact of nanomaterial application on plants, some of the