LRRC8 Family Proteins Within Lysosomes Regulate Cellular Osmoregulation and Enhance Cell Survival to Multiple Physiological Stresses
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses Ping Lia,b,1, Meiqin Hua,b,2, Ce Wanga,2, Xinghua Fengb, ZhuangZhuang Zhaob, Ying Yanga, Nirakar Sahooa,c, Mingxue Gua, Yexin Yanga, Shiyu Xiaoa, Rajan Sahd, Timothy L. Covere,f,g, Janet Chouh, Raif Gehah, Fernando Benavidesi, Richard I. Humea,1, and Haoxing Xua aDepartment of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109-1085; bCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, 310014 Hangzhou, China; cDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX 78539-2999; dCenter for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; eDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212; fDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37212; gVeterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212; hDivision of Immunology, Boston Children’s Hospital, Boston, MA 02115; and iDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957 Edited by Ardem Patapoutian, Scripps Research Institute, La Jolla, CA, and approved October 5, 2020 (received for review August 4, 2020) LRRC8 family proteins on the plasma membrane play a critical role in reduction (8, 9). Additionally, in epithelial cells of the kidney, when cellular osmoregulation by forming volume-regulated anion channels luminal water in the collecting duct rushes through aquaporin (VRACs) necessary to prevent necrotic cell death.
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