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Founded 1897 • New Series Romanian Journal of Vol. CXXI • No. 2/2018 • August Military Medicine REVISTA DE MEDICINĂ MILITARĂ • Brief notes about the Great War, Romanian military doctors and the Great Union • Reactive nitrogen species and cardiovascular diseases • Ethical limits between aesthetic and cosmetic dentistry • History of medicine on the border between philosophy and science • Therapeutic management of schizophrenia and substance use disorders dual diagnosis – clinical vignettes • Patient reported outcome measures and joint replacement • Physical effort – an underused preventable method in colorectal cancer • The communication and promotion policies of the medical organizations in the marketing of Romanian healthcare services • Medical applications of the GC/MS method in the acute intoxication with dimethoate – clinical case • Rare case of Stevens-Johnson-TEN overlap syndrome caused by mycotoxins • Uncommon giant sphenoidal tumor. Case report Journal included in Emerging Sources Citation Index, Index Copernicus International, National Library of Medicine Catalog, Ulrich’s Periodicals Directory database, OCLC WorldCat, Directory of Open Access Journals, Directory of Research Journals Index, Eurasian Scientific Journal Index, Scientific World Index, Science Library Index and Open Academic Journals Index. www.revistamedicinamilitara.ro Editorial Board of Romanian Journal of Military Medicine Under the patronage Romanian Association of Military Physicians and Pharmacists Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Honorary Editor Acad. Victor Voicu MD, PhD Editors-in-Chief Florentina Ioniță Radu MD, PhD, MBA Dan Mischianu MD, PhD Executive Editors Daniel O. Costache MD, PhD, MBA Victor L. Purcărea PhD, MBA Associate Editor Mariana Jinga MD, PhD, MBA Redactors Raluca S. Costache MD, PhD, MBA – Bucharest Mihail S. Tudosie MD, PhD – Bucharest Editorial Assistants Ioana Oprea MD Cristina Solea Technical Secretary Oana Ciobanu Ionuț Olteanu Publisher Carol Davila University of Medicine and Pharmacy Publishing House International Editorial Board Natan Børnstein (Israel) Gerard Roul (France) C. Ionescu Târgovişte (Romania) Cris S. Constantinescu (UK) Erwin Santo (Israel) Radu Ţuţuian (Switzerland) Daniel Dănilă (USA) Adrian Săftoiu (Denmark) Shyam Varadarajulu (USA) Mihai Moldovan (Denmark) Ioanel Sinescu (Romania) Peter Vilmann (Denmark) Ioan Opriș (USA) Victor Voicu (Romania) Scientific Publishing Committee Adrian Barbilian (Bucharest) Gabriel Constantinescu (Bucharest) Viorel Jinga (Bucharest) Anda Băicuş (Bucharest) Dan Corneci (Bucharest) Ovidiu Nicodin (Bucharest) Cristian Băicuş (Bucharest) Raluca S. Costache (Bucharest) Tudor Nicolaie (Bucharest) Andra Bălănescu (Bucharest) Dragoș Cuzino (Bucharest) Bogdan A. Popescu (Bucharest) Mircea Beuran (Bucharest) Mircea Diculescu (Bucharest) Emilian A. Ranetti (Bucharest) Ovidiu Bratu (Bucharest) Cosmin Dobrin (Bucharest) Corneliu Romanițan (Bucharest) Daciana Brănișteanu (Iași) Silviu Dumitrescu (Bucharest) Carmen A. Sîrbu (Bucharest) Dragoș Bumbăcea (Bucharest) Carmen G. Fierbințeanu (Bucharest) Ion Țintoiu (Bucharest) Marian Burcea (Bucharest) Cristian Gheorghe (Bucharest) Sorin G. Țiplica (Bucharest) Sofia Colesca (Bucharest) Liana S. Gheorghe (Bucharest) Daniel Vasile (Bucharest) Dumitru Constantin Dulcan (Bucharest) Mihai E. Hinescu (Bucharest) Dragoş Vinereanu (Bucharest) Ruxandra Jurcuț (Bucharest) REDACTION B-dul Eroii sanitari, Nr.8, Sector 5, București, Tel/fax 021/318.07.59, tel. 021/318.08.62/Int. 199; Email [email protected] Romanian Journal of Military Medicine (RJMM) is included in Romanian College of Physicians Medical Publications Index. www.revistamedicinamilitara.ro Romanian Journal of Military Medicine, New Series, vol. CXXI, No 2/2018, August ISSN-L 1222-5126; eISSN 2501-2312; pISSN 1222-5126 Vol. CXXI • No. 2/2018 • August • Romanian Journal of Military Medicine RJMM Founded 1897 • New Series Romanian Journal of Military Medicine Vol. CXXI • No. 2/2018 • August Edited by the Romanian Association of Military Physicians and Pharmacists. Contents EDITORIAL Dan Mischianu Brief notes about the Great War, Romanian military doctors and the Great Union 5 REVIEW ARTICLE Gabriel Gorecki, Elena Rusu, Horaţiu Moldovan, Ioan S. Tudorache Reactive nitrogen species and cardiovascular diseases 11 Marina Melescanu Imre, Elena Preoteasa, Ana Maria C. Tancu, Cristina T. Preoteasa, Mihaela Pantea, Paula Perlea Ethical limits between aesthetic and cosmetic dentistry 16 Mirela Radu History of medicine on the border between philosophy and science 21 ORIGINAL ARTICLES Octavian Vasiliu Therapeutic management of schizophrenia and substance use disorders dual diagnosis – clinical vignettes 26 Alexandra Șopu Patient reported outcome measures and joint replacement 35 Mihăiță Pătrășescu, Petruț Nuță, Raluca S. Costache, Săndica Bucurică, Bogdan Macadon, Vasile Balaban, Andrada Popescu, Roxana Călin, Ioana Răduță, Daniel Pantile, Florentina Ioniță Radu, Mariana Jinga Physical effort – an underused preventable method in colorectal cancer 41 Bogdan I. Coculescu, Victor L. Purcărea, Elena C. Coculescu The communication and promotion policies of the medical organizations in the marketing of Romanian healthcare services 46 CLINICAL PRACTICE Genica Caragea, Mihail S. Tudosie, Radu A. Macovei, Ilenuţa L. Dănescu, Mihai Ionică Medical applications of the GC/MS method in the acute intoxication with dimethoate – clinical case 50 Cristian Cobilinschi, Radu C. Țincu, Mihail S. Tudosie, Zoie Ghiorghiu, Radu A. Macovei Rare case of Stevens-Johnson-TEN overlap syndrome caused by mycotoxins 58 1 R. Hainăroșie, Irina Ioniță, Cătălina Pietroșanu, S. Pițuru, Mura Hainăroșie, V. Zainea Uncommon giant sphenoidal tumor. Case report 64 ADMINISTRATIVE ISSUES Guidelines for authors 68 2 Vol. CXXI • No. 2/2018 • August • Romanian Journal of Military Medicine 3 Vol. CXXI • No. 2/2018 • August • Romanian Journal of Military Medicine EDITORIAL Brief notes about the Great War, Romanian military doctors and the Great Union Dan Mischianu Motto: “L’Histoire, c’est la rencontré d’une volonté et d’une Versailles in 1949 in the Gral (R) Prof DAN MISCHIANU évènement” – Charles de Gaulle, 1890-1970 Mirror Hall, with multiple Chief of Urology Clinic, Carol European implications... Davila Central Emergency This short notice, largely iatrohistoric, appear in the Military Hospital 100th year since the Great Union out of the desire to Then, at Versailles in the Faculty of General Medicine, know more about what has happened. Grand Trianon Palace, a treaty Carol Davila University of was signed on June 4, 1920 Medicine and Pharmacy, Bucharest, Romania In Romania, there was a lot of talk about the First between 16 allied states World War. The Germans remember this war under (including Romania) and the successor state of the the name of "der Erste Weltkrieg worde von 1914 bis Austro-Hungarian Empire. At the beginning of the war, 1918 in Europa, in Naken Osten, in Africa, Ostasien and Romania, a "very small country", in the form of "L", auf dez ozeanen gefurt". Obviously this first had 137,000 km2 and a population of 7.2 million conflagration was the army of "Zweiter Weltkrieg"! inhabitants, and after Trianon, it was reunited and The British preferred the denomination of the became „The Great Romania", with an area of 295,000 "European War" or, more correctly, they named it "the km2 and a nation of 18 million people. It is certainly Great War". why, in the collective mentality of a neighboring It appears that this name is slowly but surely nation, that this situation is perceived as unacceptable penetrating our literature, following "World War I" even after 100 years! which, referring to the title of this editorial only makes After the assassination of the crown Prince of Austria- us Romanians remind that we have also had a Small Hungary – Franz Ferdinand on June 28, 1914 the Union (1859), followed by the Great Union of 1918. actors, both big and small, began to enter the stage: It must be remembered that the Romanian literature Central Powers – Germany, Austria-Hungary, Turkey, between 1948-1989 wrote about the Great War in an Bulgaria and Antanta or the Triple Alliance, England, abbreviated manner, because of two reasons: the Russia followed by Italy, Romania, USA... Eastern neighbors had "turned history" – things did The Kingdom of Romania had passed through a recent, not happen as planned and the contribution and unforgettable experience for the army and especially participation of the Romanian Royalty to the final for the military doctors. In 1913, during the Second victory was extremely important but also very Balkan War, the Romanian troops that had easily embarrassing that it had to be silenced. entered the northern half of Bulgaria lost 1,600 lives The Great War began in Sarajevo in 1914 and ended at due to the cholera epidemic – a fearful "enemy". 5 Evidently, the accusations have risen, obviously committees for dysfunctions research have been named, obviously the responsible military doctors – Constantin Papilian (1852-1917) and Senator G-ral (r) Prof. Dr. Athanase Demosthen (1846-1925) informed I.C. Bratianu – Prime Minister and Minister of War about all this. Certainly, the two years of neutrality have chosen better and more efficient organizational lines, as "stage sanitation, semi-hospital evacuation, evacuation hospitals, auxiliary hospitals, and infirmary He became Professor of Experimental Medicine at the station ". Faculty of Medicine in Bucharest at the age of 38 and Just