Subject Index T O Volume 74

Home , Demecolcine, Deoxycytidine deaminase, Lasalocid, Octopine, Pregnenolone succinate

Subject Index t o Volume 74

JANUARY-DECE MBER 1977

Introduction The terms in the Subject Index for Volu] ne 74, January-December 1977, of the PROCEEDINGS OF THE NATIONAL ACADEA [YOF SCIENCES USA were chosen from titles, key terms, and abstracts of articles. The index terms are alphabetized by computer; numbers, conformational prefix es, Greek letters, hyphens, and spaces between words are disregarded in alphabeti: zation. After each index term is printed the title of the article (or a suitable modifi( ation of the title) and the appropriate page number. Titles are listed in alphabeti cal order under the index terms. Classifications (e.g., Physics, Mathema tics) under which papers have been published are used as index terms only if it seemed this would be helpful. Papers that are concerned in some major way vvith methodology are indexed under "Methodology" as well as under more specifi c terms. Corrections to papers in which errors occurred are indexed under the term' 'Correction" as well as under the index terms selected for the paper itself. Organisn is are indexed by their scientific names when scientific names were provided in th e papers; suitable cross-references are provided. Because the PROCEEDINGS urges authoi s to follow the tentative rules and recommendations of the nomenclature comr aissions (e.g., for biochemistry, those proposed by the International Union of I 'ure and Applied Chemistry and the Commission on Biochemical Nomenclature ), an effort has been made to construct an index that conforms with this policy. H )wever, correction of errors in nomenclature was not attempted and the index sh ould not be looked upon as a reference for correct or recommended usage. In ad( lition, some exceptions to the recommendations of the commissions were necess. try. Index terms themselves are usually not abbreviated even if specific recommer ldations have been made by the commissions; and in some instances, words withi: i an index term were rearranged. (Thus, tRNA is indexed as "Ribonucleic acid, tra nsfer.") In general, analogues of compounds are indexed as the parent compound . (Thus, dibutyryl adenosine 3':5'-cyclic monophosphate is indexed as "Adenosine 3' :5'-cyclic monophosphate, dibutyryl-.") The "Recommended Name" from the 1972 and 1975 recommendations of the In- ternational Union of Pure and Applied ChE mistry and the International Union of Biochemistry [Enzyme Nomenclature (197 3) and Supplement 1 (1975), American Elsevier, New York] has been used for enzyr -es whenever Enzyme Commission (EC) numbers were published in the papers. EC numbers are listed as part of the entry only if the EC number was printed in the paper. [Thus, some enzymes have two entries, e.g., "Adenosinetriphosphatase" and "Adenosinetriphosphatase (EC 3.6.1.3)."]

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PAGINATIOr [ OF ISSUES

Pages Issue Month Pages Iss ue Month Pages Issue Month

1-392 1 January 1765-2188 5 May 3623-4110 9 September 393-800 2 February 2189--2594 6 June 4111-4706 10 October 801-1302 3 March 2595-3104 7 July 4707-5198 11 November 1303-1764 4 April 3105-3622 8 August 5199-5870 12 December

Accident proneness Actin Compound Poisson distribution: Prediction and estimation, 2670 Actin microheterogeneity in chick embryo fibroblasts, 120 Acetic anhydride Antibody-induced linkages of plasma membrane proteins to intracellular Physical properties of chemically acetylated rat liver chromatin, 3244 actomyosin-containing filaments in cultured fibroblasts, 5584 Acetoacetyl CoA thiolase Calcium control of actin-activated myosin adenosine triphosphatase from see Acetyl-CoA acetyltransferase Dictyostelium discoideum (correction), 392 N- Acetoxy-2-acetylaminofluorene Defective organization of actin in cultured skin fibroblasts from patients Differences in removal of acetylaminofluorene and pyrimidine dimers with inherited adenocarcinoma, 3019 from DNA of cultured mammalian cells, 1553 HeLa cell poly(A)- mRNA codes for subset of poly(A)+ mRNA-directed Different rate-limiting steps in excision repair of ultraviolet- and proteins with actin as major product, 4801 N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human Intracellular distributions of mechanochemical proteins in cultured fibroblasts, 1548 fibroblasts, 3883 Acetylchitobiose, di-N- Phalloidin-induced actin polymerization in cytoplasm of cultured cells Protein-sugar interactions: Preparation, purification, and properties of interferes with cell locomotion and growth, 5613 rabbit antibodies against di-N-acetylchitobiose, 168 Phosphorylation of smooth muscle myosin affects actin activation and Acetylcholine Ca2+ regulation, 129 see also Receptor, acetylcholine Transmembrane interactions and mechanism of capping of surface Acetylcholine: Storage and release by a clonal cell line, 5184 receptors by their specific ligands, 5031 Affinity alkylation labels two subunits of reduced acetylcholine receptor Actin, F from mammalian muscle, 4685 Interaction of filamin with F-actin in solutioin, 2021 Cholinergic metabolism and synapse formation by a rat nerve cell line, Actin-like protein 2579 Actin-like protein extracted from prokaryote Mycoplasma pneumoniae, Determination of transmitter function by neuronal activity, 5767 4041 Distinctions between two-state and sequential models for cooperative Actinomycin D ligand binding, 139 Biological function of gramicidin: Selective inhibition of RNA Dynamic properties of isolated acetylcholine receptor proteins: Release polymerase, 1478 of calcium ions caused by acetylcholine binding (correction), 1763 Induction and decay of human fibroblast interferon mRNA, 4415 Immunological distinction between acetylcholine receptor and Action potential a-bungarotoxin-binding component on sympathetic neurons, 4689 Action potentials occur in cells of normal anterior pituitary gland and Modulation of acetylcholine receptor by antibody against receptor, 3090 are stimulated by hypophysiotropic peptide thyrotropin-releasing Opposing effects of dopaminergic to cholinergic compounds on cerebral hormone, 4064 dopamine-activated adenylate cyclase, 769 Batrachotoxin affects electroplax of electric eel: Voltage-dependent Synaptic acetylcholine receptor sites identified in retina with interaction with sodium channels, 951 peroxidase-labeled a-bungarotoxin, 3268 Molecular events and energy changes during action potential, 3810 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Sensitivity, polarity, and conductance change in response of vertebrate activity by choline: Choline administration can increase cholinergic hair cells to controlled mechanical stimuli, 2407 transmission, 798 Subthreshold solutions of the Hodgkin-Huxley equations, 5199 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Actomyosin activity by choline: Choline administration can increase cholinergic Antibody-induced linkages of plasma membrane proteins to intracellular transmission (correction), 2594 actomyosin-containing filaments in cultured fibroblasts, 5584 Acetylcholinesterase Acupuncture Development of electrophysiological and biochemical membrane Mysterious form of referred sensation in man, 4702 properties during differentiation of embryonic skeletal muscle in Acyl-CoA synthetase (EC 6.2.1.3) culture, 5166 Candida lipolytica mutants defective in acyl-coenzyme A synthetase: Acetyl-CoA acetyltransferase (EC 2.3.1.9) Isolation and fatty acid metabolism, 4947 Cholesterol synthesis in rat adrenal gland regulated through coordinate Adaptation control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and Cost of evolution and imprecision of adaptation, 1647 reductase activities, 1421 Sensory transduction in Escherichia coli: Role of protein methylation Multi-enzyme complex of fatty acid oxidation isolated from Escherichia reaction in sensory adaptation, 4964 coli, 492 Adenine, 9-f-D-arabinofuranosyl- Acetyl-CoA carboxylase (EC 6.4.1.2) Conformational basis for activation of adenylate cyclase by adenosine, Acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in 2194 liver cell, 1497 Influence of 9-0-D-arabinofuranosyladenine on total protein synthesis fl-N-Acetylgalactosaminyltransferase (EC 2.4.1.79) and on differential gene expression of unique proteins in the rodent Defects of glycosyltransferase activities in human fibroblasts of pk and p malarial parasite Plasmodium berghei, 3386 blood group phenotypes, 5407 Adenine 5'-diphosphate ribosylation N-Acetylglucosamine Gangliosides and substrate analogues affect hydrolysis of nicotinamide Cell surface carbohydrates and proteins in cell behavior: Biochemical adenine dinucleotide by choleragen, 74 reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 Adeno-associated virus Enzyme-substrate complexes of lysozyme: Structures, 2629 Helper factor(s) for growth of adeno-associated virus in cells transformed N-Acetylglucosamine incorporated into endogenous acceptors of rough by adenovirus 12, 4508 microsomes from rat liver: Stimulation by GTP after treatment with Adenocarcinoma pyrophosphate, 1095 Defective organization of actin in cultured skin fibroblasts from patients Acetyl transfer with inherited adenocarcinoma, 3019 Kinetic evidence for an intermediate in deacetylation of Establishment and characterization of a strain of human adrenal tumor monoacetyl-chymotrypsin, 510 cells that secrete estrogen, 1067 Achlya Adenomatosis of colon and rectum DNA sequence organization in water mold Achlya, 4332 Defective organization of actin in cultured skin fibroblasts from patients Acid protease with inherited adenocarcinoma, 3019 Homology among acid proteases: Comparison of crystal structures at 3A Adenosine resolution of acid proteases from Rhizopus chinensis and Endothia Adenylate cyclase from synchronized neuroblastoma cells: parasitica, 556 Responsiveness to prostaglandin El, adenosine, and dopamine during Acridine, 9-amino- cell cycle, 1575 Mutagen-nucleic acid intercalative binding: Structure of Conformational basis for activation of adenylate cyclase by adenosine, 9-aminoacridine-5-iodocytidylyl(3'-5')guanosine crystalline complex, 2194 188 Two distinct adenosine-sensitive sites on adenylate cyclase, 5482 Acridine orange Adenosine 3':5'-cyclic monophosphate, dibutyryl Analysis of single- and double-stranded nucleic acids on polyacrylamide Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to and agarose gels by using glyoxal and acridine orange, 4835 ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 Acrodermatitis enteropathica Number of receptors for ,-melanocyte stimulating hormone in Cloudman Zinc-binding ligands in milk and intestine: Role in neonatal nutrition? melanoma cells is increased by dibutyryl adenosine 3':5'-cyclic 3547 monophosphate or cholera toxin, 601 Acrosome Adenosine 3':5'-cyclic monophosphate in animal cells Isolation of bindin: Protein responsible for adhesion of sperm to sea Activation of cardiac adenylate cyclase: Hormonal modification of urchin eggs, 2456 magnesium ion requirement, 92 Downloaded by 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Activation of hormone-sensitive lipase and phosphorylase kinase by Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during purified cyclic GMP-dependent protein kinase, 4843 cell cycle of mouse mastocytoma cells, 1610 Acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during liver cell, 1497 cell cycle of mouse mastocytoma cells (correction), 3621 Adenosine 3':5'-cyclic monophosphate- and guanosine 3':5'-cyclic Oligomycin-dependent ionophoric protein subunit of mitochondrial monophosphate-dependent protein kinases: Possible homologous adenosinetriphosphatase, 4306 proteins, 3239 Roles of proteins from inner face of plasma membranes in susceptibility Antagonism of histamine-activated adenylate cyclase in brain by of (Na+ + K+)-stimulated Mg2+ adenosinetriphosphatase to ouabain, D-lysergic acid diethylamide, 5697 633 Cell-cycle-related changes of 3':5'-cyclic GMP levels in Novikoff Troponin-like complex isolated from bovine brain cortex, 2273 hepatoma cells, 1052 Adenosine 5'-triphosphate Colchicine affects cyclic AMP levels in human leukocytes, 3404 see also Nucleoside 5'-triphosphate Collagen synthesis by chondrocytes in suspension culture: Modulation by Amino-acid transport into Ehrlich cells: Unexpected additional mode of calcium, 3':5'-cyclic AMP, and prostaglandins, 3864 energization, 1488 3':5'-Cyclic AMP and hormonal control of puparium formation in fleshfly Effect of MgATP on stiffness measured at two frequencies in Sarcophaga bullata, 2182 Ca2+-activated muscle fibers, 4073 3':5'-Cyclic-AMP-dependent protein kinase in regulation of protein H+/ATP ratio during ATP hydrolysis by mitochondria: Modification synthesis in reticulocyte lysates, 1463 of chemiosmotic theory, 1955 3':5'-Cyclic AMP: Independent induction of amino acid transport by Inactivation and proteolytic cleavage of phage X repressor in vitro in an epinephrine in primary cultures of adult rat liver cells, 234 ATP-dependent reaction, 2283 3':5'-Cyclic AMP: Independent induction of amino acid transport by Interaction of tetraiodofluorescein with a modified form of aspartate epinephrine in primary cultures of adult rat liver cells (correction), transcarbamylase, 111 2187 31p nuclear magnetic resonance measurements of ATPase kinetics in Cyclic AMP, microtubule-microfilament system, and cancer, 4491 aerobic Escherichia coli cells, 5551 Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic Soluble ATP-dependent proteolytic system responsible for degradation GMP from induction of ornithine decarboxylase by tumor promoter of abnormal proteins in reticulocytes, 54 12-0-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo, 657 Adenosine 3'(2')-triphosphate 5'-triphosphate synthetase Dopaminergic stimulation of cyclic AMP accumulation and parathyroid Control of development: Isolation of Bacillus subtilis mutants blocked hormone release from dispersed bovine parathyroid cells, 4210 early in sporulation and defective in synthesis of highly Glucocorticoids increase responsiveness of cells in culture to phosphorylated nucleotides, 1125 prostaglandin El, 4816 S- Adenosylmethionine Gonadotropin-induced regulation of luteinizing hormone receptors and Protein methyltransferase identified as cheR gene product in bacterial desensitization of testicular 3':5'-cyclic AMP and testosterone sensing system, 533 responses, 592 Adenovirus Hepatic nuclear guanylate cyclase: Regulation, 946 Amber and ochre mutants of human virus Ad2+ndl identified, 4567 Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic Evidence from UV transcription mapping in HeLa cells that GMP in rat renal cortex: Effect of parathyroid hormone, 3569 heterogeneous nuclear RNA is the messenger RNA precursor, 4520 Induction of functional ?-adrenergic receptors in HeLa cells, 873 Helper factor(s) for growth of adeno-associated virus in cells transformed Intermediate role of adenosine 3':5'-cyclic monophosphate and protein by adenovirus 12, 4508 kinase during gonadotropin-induced steroidogenesis in testicular Loop structures in hybrids of early RNA and separated strands of interstitial cells, 3419 adenovirus DNA, 4392 In vivo and in vitro phosphorylation of rat liver Replication of adenovirus type 2 DNA in vitro, 4425 fructose-1,6-bisphosphatase, 4615 Site-specific single-strand endonuclease from the eukaryote Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of Chlamydomonas, 2687 GTP hydrolysis at regulatory site, 3307 Spliced segments at 5' terminus of adenovirus 2 late mRNA, 3171 Mechanism of translational control by hemin in reticulocyte lysates, 3326 Type 5 adenovirus DNA persists in cells transformed by a Nitric oxide activates guanylate cyclase and increases guanosine temperature-sensitive mutant, H5ts 125, 785 3':5'-cyclic monophosphate levels in various tissue preparations, 3203 Adenylate cyclase Opposing effects of dopaminergic to cholinergic compounds on cerebral Gangliosides and substrate analogues affect hydrolysis of nicotinamide dopamine-activated adenylate cyclase, 769 adenine dinucleotide by choleragen, 74 Role of ecdysone, pupariation factors, and cyclic AMP in formation and Light-activated GTPase in vertebrate photoreceptors: Regulation of tanning of puparium of fleshfly Sarcophaga bullata, 4697 light-activated cyclic GMP phosphodiesterase, 4238 Subunit interaction in cyclic AMP-dependent protein kinase of mutant Two distinct adenosine-sensitive sites on adenylate cyclase, 5482 lymphoma cells, 1167 Adenylate cyclase (EC 4.6.1.1) Adenosine 3':5'-cyclic monophosphate in microorganisms Activation of cardiac adenylate cyclase: Hormonal modification of 3':5'-Cyclic AMP-dependent 3':5'-cyclic GMP accumulation in magnesium ion requirement, 92 Dictyostelium discoideum, 2348 Adenylate cyclase-free, i-adrenergic receptor isolated from turkey Unified mechanism for relay and oscillation of cyclic AMP in erythrocyte membranes by affinity chromatography, 3710 Dictyostelium discoideum, 1543 Adenylate cyclase from synchronized neuroblastoma cells: Adenosine deaminase (EC 3.5.4.4) Responsiveness to prostaglandin El, adenosine, and dopamine during Lymphospecific toxicity in adenosine deaminase deficiency and purine cell cycle, 1575 nucleoside phosphorylase deficiency: Role of nucleoside kinase(s), 5677 Adenylate cyclase permanently uncoupled from hormone receptors in Adenosine, N6,N6-dimethyl- novel variant of S49 mouse lymphoma cells, 2016 Ribosome structure: Localization of N6,N6-dimethyladenosine by l-Adrenergic receptors probed by fluorescent 1-adrenergic blockers, 5290 electron microscopy of a ribosome-antibody complex, 1468 Antagonism of histamine-activated adenylate cyclase in brain by Adenosine dinucleotide D-lysergic acid diethylamide, 5697 Circular dichroism of adenosine dinucleotides, 1785 Catecholamine binding to 3-adrenergic receptor, 515 Adenosine 5'-diphosphate-ribose Catecholamine hormone receptor differences identified on 3T3 and Transfer of ADP-ribose from NAD to choleragen: A subunit acts as simian virus-transformed 3T3 cells, 1091 catalyst and acceptor protein, 5440 Choleragen activation of solubilized adenylate cyclase: GTP and protein Adenosine 5'-monophosphate activator required for demonstration of enzymatic activity, 4396 Nucleic acid components: Ultraviolet resonant Raman spectroscopy, 2639 Conformational basis for activation of adenylate cyclase by adenosine, Adenosine 5'- O- (1-thiotriphosphate) 2194 Stereochemistry of polymerization by DNA-dependent RNA polymerase Dopamine-dependent adenylate cyclase: Quantitative correlation with from Escherichia coli: Investigation with a diastereomeric responses to levodopa in various mice, 1242 ATP analogue (correction), 392 Induction of functional 1-adrenergicreceptors in HeLa cells, 873 Adenosinetriphosphatase L-3,4-Dihydroxyphenylalanine-induced hypersensitivity simulating Dynein identified as outer arms of sea urchin sperm axonemes, 5006 features of denervation, 2126 Phosphorylation of smooth muscle myosin affects actin activation and Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of Ca2+ regulation, 129 GTP hydrolysis at regulatory site, 3307 31P nuclear magnetic resonance measurements of ATPase kinetics in Opiate-dependent modulation of adenylate cyclase, 3365 aerobic Escherichia coli cells, 5551 Opposing effects of dopaminergic to cholinergic compounds on cerebral Reconstitution of thermostable ATPase capable of energy coupling from dopamine-activated adenylate cyclase, 769 its purified subunits, 936 Proteolytic enzyme activation of rat ovarian adenylate cyclase, 4857 Adenosinetriphosphatase (EC 3.6.1.3) Reconstitution of catecholamine-sensitive adenylate cyclase activity: Antibody-induced linkages of plasma membrane proteins to intracellular Interaction of solubilized components with receptor-replete actomyosin-containing filaments in cultured fibroblasts, 5584 membranes, 3715 4,4'-Bis(1-anilinonaphthalene 8-sulfonate): Probe of active site of Topographic separation of adenylate cyclase and hormone receptors in myosin, 2334 plasma membrane of toad erythrocyte ghosts, 2860 Calcium control of actin-activated myosin adenosine triphosphatase from Transfer of ADP-ribose from NAD to choleragen: A subunit acts as Dictyostelium discoideum (correction), 392 catalyst and acceptor protein, 5440 Fi-ATPase-catalyzed synthesis of ATP from oleoylphosphate and ADP, Unified mechanism for relay and oscillation of cyclic AMP in 4919 Dictyostelium discoideum, 1543 High-resolution 31p nuclear magnetic resonance studies of metabolism in Adenylate kinase (EC 2.7.4.3) aerobic Escherichia coli cells, 888 Adenylate kinase: 31p nuclear magnetic resonance kinetic measurements, Location of protein(s) involved in oligomycin-induced inhibition of 3627 mitochondrial adenosinetriphosphatase near outer surface of inner Asymmeteic binding of the inhibitor di(adenosine-5') pentaphosphate membrane, 4185 (ApsA) to adenylate kinase, 5355 Downloaded by guest on September 27, 2021 5784 Subject Index Proc. 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Adipocyte Aldosterone Alterations in insulin binding accompanying differentiation of 3T3-L1 Specific receptors for des-Aspl-angiotensin II ("angiotensin III") in rat preadipocytes, 4876 adrenals, 4029 Adrenal gland Alfalfamosaic virus Cholesterol synthesis in rat adrenal gland regulated through coordinate Nucleotide sequence of 5' terminus of alfalfa mosaic virus RNA 4 leading control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and into coat protein cistron, 5504 reductase activities, 1421 Polypeptide synthesis initiated with various NH2-blocked Detection in bovine adrenal cortex of a lipoidal substance that yields aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5509 pregnenolone upon treatment with alkali, 941 Alga, prokaryotic ?-Endorphin: Pituitary and adrenal glands modulate its action, 4628 Chlorophyll b identified in extracts of prokaryotic algae by fluorescence Specific neural and adrenal medullary antigens detected by antisera to spectroscopy, 575 clonal PC12 pheochromocytoma cells, 5021 Aliphaticdisulfide Specific receptors for des-Aspl-angiotensin II ("angiotensin III") in rat Stable conformationsof aliphaticdisulfides: Influence of 1,4 interactions adrenals, 4029 involvingsulfur atoms, 13 Stimulus-secretion coupling in chromaffin cells isolated from bovine Aliphatictripeptide adrenal medulla, 5036 Nitrogen-15 nuclear magnetic resonance of aliphatic tripeptides, 1,308 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Alkali-iongradient activity by choline: Choline administration can increase cholinergic Amino-acidtransport into Ehrlichcells: Unexpectedadditional mode of transmission, 798 energization,1488 'Irans-synaptic induction of adrenomedullary tyrosine hydroxylase Alkalinephosphatase (EC 3.1.3.1) activity by choline: Choline administration can increase cholinergic Dephosphorylation inactivates glucocorticoid receptors, 1398 transmission (correction), 2594 Escherichiacoli alkalinephosphatase precursor: Synthesis and Adrenocorticotropic hormone processing in vitro, 1440 see Corticotropin Extracellularlabeling of nascent polypeptidestraversing the membrane Aequorin of Escherichiacoli, 2830 Calcium-induced luminescence of aequorin: Reversible and irreversible Allele frequency inhibition by anesthetics, 5534 Genetic variability maintained under mutation and selection pressures in Free calcium increases explosively in activating medaka eggs, 623 a finite population,2509 Voltage-dependent facilitation of Ca2+ entry in voltage-clamped, Alloantigen aequorin-injected molluscan neurons, 1748 Lymphocyte alloantigens associated with X-chromosome-linked immune Affinity constant response genes, 721 4,4'-Bis(1-anilinonaphthalene 8-sulfonate): Probe of active site of Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator myosin, 2334 cells exhibit specificity for H-2 complex alloantigens, 4572 Aflatoxin B1 Alloplex intermediate Structural identification of major DNA adduct formed by aflatoxin B1 in Native human hemoglobin reconstituted from separated globin chains vitro, 1870 and alloplexintermediates, 64 Agammaglobulinemia Allostericinhibitor Immunoglobulin-dependent antigen-specific helper T cell, 4582 Binding of Zn2+to rat liver fructose-1,6-bisphosphataseand its effect on Age incidence catalytic properties,2742 Age incidence curves for cancer, 1341 Allostericmechanism Agglutination Energy-structure correlation in metalloporphyrins and control of oxygen Changes in surface properties of normal and transformed cells caused by bindingby hemoglobin,1789 tunicamycin, inhibitor of protein glycosylation, 3433 Interactionof tetraiodofluoresceinwith a modifiedform of aspartate Role of sialic acid in survival of erythrocytes in circulation: Interaction of transcarbamylase,111 neuraminidase-treated and untreated erythrocytes with spleen and Superiorityof interconvertibleenzyme cascades in metabolicregulation: liver at cellular level, 1521 Analysisof monocyclicsystems, 2761 Agglutinin, cold Allostericmodel Waldenstrom macroglobulin that is a cold agglutinin and a cryoglobulin Unified mechanismfor relay and oscillationof cyclic AMP in because it binds N-acetylneuraminosyl residues, 4591 Dictyostelium discoideum,1543 Aggression Allostericprotein Colony-specific territorial pheromone in African weaver ant Oecophylla see also Enzyme, allosteric longinoda (Latreille), 2072 Monomericform of pyruvatekinase in humanpyruvate kinase Aging deficiency, 501 see also Longevity Almost periodicsolution Translational error theory of aging, 3396 Hyperbolicalmost periodicsolutions and toroidallimit sets, 3124 Aging, cell Altitude Extension of lifespan of cultured normal human diploid cells by vitamin Reductionof pore area of avian eggshellas adaptationto altitude, 3095 E: Reevaluation, 1640 Aluminum Agrobacterium tumefaciens 13C nuclear magnetic resonance study of five- and six-coordinated carbon Thermosensitive step associated with transfer of Ti plasmid during in nonclassical organometallic compounds: Dimeric trialkyl-, conjugation: Relation to transformation in crown gall, 2848 tricyclopropyl-,and triarylaluminumsand some nido and closo Alamethicin carboranes,5217 Synthesis of a 19-residue peptide with alamethicin-like activity, 115 a-Amanitin D-Alanine carboxypeptidase NucleoplasmicRNA: Definitionof subclasses,5011 Mutants of Escherichia coli lacking in highly penicillin-sensitive Amine oxidase (pyridoxal-containing)(EC 1.4.3.6) i)-alanine carboxypeptidase activity, 2976 Histaminase(diamine oxidase) activity in humantumors: Expression of' Penicillin-binding peptide isolated from D-alanine carboxypeptidase of a mature genome, 883 Bacillus subtilis, 1009 Amino acid Simultaneous deletion of D-alanine carboxypeptidase IB-C and see specific amino acids penicillin-binding component IV in mutant of Escherichia coli K12, Amino-acidactivation 2980 Isolationof amino acid activatingsubunit-pantetheine protein Thermosensitive mutation in Escherichia coli simultaneously causing complexes:Role in chain elongationin tyrocidinesynthesis, 2343 defects in penicillin-binding protein-lBs and in enzyme activity for Amino-acidmetabolism peptidoglycan synthesis in vitro, 5472 Isolation and identification of aliphatic short-chain acylcarnitines from Albumin beef heart:Role for carnitinein branched-chainamino acid see also Parvalbumin; Preproalbumin; Proalbumin metabolism, 2795 Albumin synthesis in mouse uterus in response to liver mRNA, 1894 Amino-acidsequence Cell-free synthesis of fourth component of guinea pig complement (C4): see also Peptide map;Protein structure Identification of precursor of serum C4 (pro-C4), 1707 Amino acid sequence for peptide extension on prolipoprotein of Distribution of rat liver albumin RNA in membrane-bound and free Escherichia coli outer membrane, 1004 polyribosomes as determined by molecular hybridization, 5397 Amino acid sequenceof humanprothrombin fragments 1 and 2, 1969 Alcohol Amino-acidsequence of myosin fragmentthat containsSH-1, SH-2, and Adaptive response due to changes in gene regulation: Study with NT-methylhistidine,4281 Drosophila, 4562 Amino-acidsequence of NH2-terminalextra piece segmentsof precursors Alcohol dehydrogenase of mouse immunoglobulinXl-type and K-type light chains,716 Extension of longevity in Drosophila mojavensis by environmental Amino acid sequence of precursor region of MOPC-315 mouse ethanol: Differences between subraces, 387 immunoglobulin heavy chain, 5692 Alcoholdehydrogenase (EC 1.1.1.1) Amino acid sequence of rabbit muscle glycogen phosphorylase, 4762 Adaptiveresponse due to changesin gene regulation:Study with Amino acid sequence of the first 217 residues of mouse heavy chain Drosophila, 4562 (MOPC 47A) with a domain deletion, 2465 Isolationof 7r-alcoholdehydrogenase of humanliver: Determinant of Amino-terminalsequences of two polypeptidesfrom humanserum with alcoholism? 4378 nonsuppressible insulin-like and cell-growth-promoting activities: Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, Structural homology with insulin B chain (correction), 1301 2514 Chemicalcharacterization of murineIa alloantigensdetermined by Alcoholism I-E/I-C subregions of H-2 complex, 5131 Isolation of sr-alcohol dehydrogenase of human liver: Determinant of C-reactiveprotein and complementsubcomponent Clt characterizedas alcoholism? 4378 homologous proteins diplaying cyclic pentameric symmetry (pentraxins),739 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) SubjectIndex 5785

Cytochrome b5: Primary structure of membranous segment, 3725 Androgen Delta-electroencephalogram(-sleep)-inducing peptide: Characterization, see also specific androgens 1282 Genetic controlof renin activity in submaxillarygland of the mouse, ?-Galactosidase of Escherichia coli: Amino acid sequence, 1507 1185 Heavy chain of HLA antigens: Structural studies and similarity to 9S bindingprotein for androgensand progesterone,1960 immunoglobulins, 4002 Androgenesis Hepatitis B surface antigen: Partial amino-acid sequence of' two major Microsurgicallyproduced homozygous-diploid uniparental mice, 5657 component polypeptides, 1530 Anemia Human platelet factor 4: Amino acid sequence, 2256 1-Aminolevulinatedehydratase, uroporphyrinogen-I synthase, and Independent expression of gene coding for constant domain of protoporphyrinIX: Levels in erythrocytesfrom anemicmutant mice, immunoglobulin light chain: Sequence analyses of precursor of 1181 constant region polypeptide, 3157 Anemia,hemolytic Isopeptide linkage between nonhistone and histone 2A polypeptides of Human erythrocytepyrimidine 5'-nucleotidase: Purification and chromosomal conjugate-protein A24, 864 properties, 3701 Lactate dehydrogenase isozymes: Structural adaptations, 2677 Ligandsand oxidants in ferrihemochromeformation and oxidative Nitrogen-15 nuclear magnetic resonance of aliphatic tripeptides, 1308 hemolysis,2556 Oligopeptides as potential antiaggregation agents for deoxyhemoglobin Anemia,sickle cell S, 5431 Alternativeaspirins as antisicklingagents: Acetyl-3,5-dibromosalicylic Oligosaccharides in human IgAl and IgA2 immunoglobulins: Location acid, 5499 and structural significance, 2301 Electron microscopy of fibers and discs of hemoglobin S having sixfold Ordering of cyanogen bromide peptides of type III collagen based on symmetry,5538 homology to type I collagen: Preservation of sites for crosslink Ligand kinetics of hemoglobinS containingerythrocytes, 203 formation during evolution, 84 Oligopeptidesas potential antiaggregationagents for deoxyhemoglobin Partial amino-acid sequences of human and rabbit C-reactive proteins: S, 5431 Homology with immunoglobulins and histocompatibility antigens, Anesthetic 1214 see also Analgesia Primary structure of human C-reactive protein, 3148 Calcium-inducedluminescence of aequorin:Reversible and irreversible Primary structure of very low density apolipoprotein C-II of human inhibitionby anesthetics,5534 plasma, 1942 Cholinergicligands and local anestheticsinteract with plasmamembrane Prochymosin: Complete amino acid sequence, 2321 fragmentsfrom lobsteraxon, 2278 Proteolytic cleavage causes heterogeneity present in human Nuclearmagnetic resonance studies of interactionof generalanesthetics ceruloplasmin preparations: Chemical evidence, 5377 with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholinebilayer Rat liver preproalbumin: In vitro synthesis and partial amino acid (correction),3621 sequence, 1358 Perhydrohistrionicotoxin:Potential ligand for ion conductance Sequence variability in immunoglobulins: Structural implications, 2551 modulator of acetylcholine receptor, 2172 Structure of murine Ia antigens: Partial NH2-terminal amino-acid Angiotensin sequences of products of I-E or I-C subregion, 5135 Angiotensinstimulation of bovine adrenocorticalcell growth,5569 Thymosin a1: Isolation and sequence analysis of immunologically active Different contractile mechanisms for angiotensin II and thymic polypeptide, 725 des-Aspl-angiotensinII in rabbitaortic strips, 5725 Aminoacyl tRNA synthetases Genetic controlof renin activity in submaxillarygland of the mouse, see also Asparaginyl-tRNA synthetase; Leucyl-tRNA synthetase 1185 Kinetic proofreading in aminoacylation of tRNA by synthetase, 2246 Specific receptorsfor des-Aspl-angiotensinII ("angiotensinIII") in rat y-Aminobutyric acid adrenals,4029 Mechanisms by which diazepam, muscimol, and other drugs change the Anisodorisnobilis content of cGMP in cerebellar cortex, 3592 Voltage-dependentfacilitation of Ca2+entry in voltage-clamped, a-Aminoisobutyric acid aequorin-injectedmolluscan neurons, 1748 3':5'-Cyclic AMP: Independent induction of amino acid transport by Anoxia epinephrine in primary cultures of adult rat liver cells, 234 Affinity of intact Escherichiacoli for hydrophobicmembrane probes is a 3':5'-Cyclic AMP: Independent induction of amino acid transport by function of the physiological state of cells, 1811 epinephrine in primary cultures of adult rat liver cells (correction), Calciummodulation in brain extracellularmicroenvironment 2187 demonstratedwith ion-selectivemicropipette, 1287 Tritium suicide selection of mammalian cell mutants defective in Ant transport of neutral amino acids, 4549 see Oecophyllalonginoda b-Aminolevulinate synthase (EC 2.3.1.37) Antamanide Postulated deficiency of hepatic heme and repair by hematin infusions in Watermolecules: Arrangement in cavities and channelsof lattice of "inducible" hepatic porphyrias, 2118 [Phe4Val6]antamanidedodecahydrate, 2602 Regulation of heme pathway enzymes and cellular glutathione content Anthocidariscrassispina by metals that do not chelate with tetrapyrroles: Blockade of metal Dynein identified as outer arms of sea urchinsperm axonemes,5006 effects by thiols, 1875 Anthocyanin B-Aminolevulinic acid dehydratase Controllingelement-induced alterations in UDPglucose:flavonoid see Porphobilinogen synthase glucosyltransferase,the enzymespecified by bronzelocus in maize, Aminopeptidase (EC 3.4.11.2) 5623 Antibody-induced linkages of plasma membrane proteins to intracellular Antibiotic actomyosin-containing filaments in cultured fibroblasts, 5584 see also Peptide antibiotic;specific antibiotics d-Aminopropionitrile Aminoglycoside-modifyingenzyme of antibiotic-producingbacterium Reduction of blood pressure and vascular collagen in hypertensive rats acts as determinantof antibioticresistance in Escherichiacoli, 999 by 3-aminopropionitrile, 360 Animalcell mutants defective in sterol metabolism:Specific selection 2-Aminopurine procedure and partial characterization of defects, 3730 2-Aminopurine-induced mutagenesis in T4 bacteriophage: Model relating Isolationof amino acid activatingsubunit-pantetheine protein mutation frequency to 2-aminopurine incorporation in DNA, 4806 complexes:Role in chain elong'ationin tyrocidinesynthesis, 2343 4-Aminopyrazolopyrimidine Netropsin-poly(dA-dT)complex in solution:Structure and dynamicsof Cholesterol synthesis in rat adrenal gland regulated through coordinate antibiotic-freebase pair regionsand those centeredon bound control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and netropsin,5207 reductase activities, 1421 Potassiumionophore (valinomycin) inhibits lymphocyteproliferation by Ampicillin its effects on cell membrane(correction), 392 Deletions affecting transposition of antibiotic resistance gene, 702 Transition state structures of dipeptide related to mode of action of a-Amylase (EC 3.2.1.1) ,-lactam antibiotics,5239 Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, Antibody 2514 see also Receptor,antibody Transport of a-amylase across basolateral membrane of pancreatic Antibodyaffinity acinar cell, 4068 Antibodyaffinity enhancedin sublethallyirradiated mice and bone Amyloid P-component marrowchimeras, 707 C-reactive protein and complement subcomponent Clt characterized as Antibodyagainst carbohydrates homologous proteins diplaying cyclic pentameric symmetry Idiotypic regulation of immune system by induction of antibodies against (pentraxins), 739 anti-idiotypic antibodies, 5126 Analgesia Antibodyagainst C-type virus see also Anesthetic Natural humanantibodies reactive with primatetype-C viral antigens, /3-Endorphin:Development of toleranceand its reversalby 1237 5-hydroxytryptophanin cats, 4017 Antibodyagainst di-N-acetylchitobiose Immunohistochemicalanalysis of peptide pathwayspossibly related to Protein-sugarinteractions: Preparation, purification, and propertiesof pain and analgesia:Enkephalin and substanceP, 3081 rabbit antibodiesagainst di-N-acetylchitobiose,168 Analytictorsion Antibodyagainst estrogen receptor Analytictorsion and Reidemeistertorsion, 2651 Antibodiesto estrogenreceptor: Immunochemical similarity of Anaphlatoxin estrophilinfrom variousmammalian species, 3681 Synthetic peptides with biologicalactivities and specificityof human Antibodyagainst influenzavirus C3a anaphylatoxin,1826 Antibodiesagainst influenza virus producedby somatic cell hybrids betweenmouse myelomaand primedspleen cells, 2985 Downloaded by guest on September 27, 2021 5786 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Antibody against nucleoside Antigen, hepatitis B surface Ribosome structure: Localization of N6,N6-dimethyladenosine by Hepatitis B surface antigen: Partial amino-acid sequence of two major electron microscopy of a ribosome-antibody complex, 1468 component polypeptides, 1530 Antibody against ribonuclease Antigen, histocompatibility Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits, 5122 Heavy chain of HLA antigens: Structural studies and similarity to Antibody against tubulin immunoglobulins, 4002 Antibodies to tubulin in normal nonimmunized animals, 3997 HLA-D associated alloantisera react with molecules similar to Ia Antibody against virus antigens, 3533 Chemical transformation of rat cell infected with xenotropic type-C Killer cells reactive to altered-self antigens can also be alloreactive, 2094 RNA virus and its suppression by virus-specific antiserum, 579 Moloney leukemia virus-induced cell surface antigen: Detection and Antibody, auto- characterization in sodium dodecyl sulfate gels, 5270 Antibodies to tubulin in normal nonimmunized animals, 3997 Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator Filaments 7-10 nm thick visualized in cultured cells of an epithelioid line cells exhibit specificity for H-2 complex alloantigens, 4572 (Pt K2) by immunofluorescence microscopy, 2490 Partial amino-acid sequences of human and rabbit C-reactive proteins: Antibody diversity Homology with immunoglobulins and histocompatibility antigens, Location of palindromes in immunoglobulin genes, 2526 1214 Antibody, incomplete Antigen, Ia Conversion of incomplete antibodies to direct agglutinins by mild Chemical characterization of murine Ia alloantigens determined by reduction: Segmental flexibility within Fc fragment of I-E/I-C subregions of H-2 complex, 5131 immunoglobulin G, 2531 HLA-D associated alloantisera react with molecules similar to Ia Antibody localization antigens, 3533 Bovine brain filament antibody localized on intermediate (100 A) Ia antigens derived from murine thymocytes: Partial chemical filaments in guinea pig vascular endothelial cells and chick cardiac characterization, 1195 muscle cells, 662 Proliferative and plaque-forming cell responses inhibited by human Antibody, polyfunctional bone-marrow-derived lymphocytes from peripheral blood by antisera Multispecific lymphoid cell surface receptors, 1224 to p23,30 antigen, 711 Antibody production Structure of murine Ia antigens: Partial NH2-terminal amino-acid Endotoxin-induced serum factor controlling differentiation of sequences of products of I-E or I-C subregion, 5135 bone-marrow-derived lymphocytes, 1200 Antigen, Ia-like Antibody synthesis Expression of Ia-like antigen molecules on human granulocytes during Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits, 5122 early phases of differentiation, 4012 Anticonvulsant Antigenic crossreactivity Ethylphenacemide and phenacemide: Conf'ormational similarities to Antigenic crossreactivity to RDI 14 p30 protein, expressed in a human diphenylhydantoin and stereochemical basis of anticonvulsant activity, fibrosarcoma cell line, 744 1264 Antigen, macrophage-bound Antidiuretic hormone Unprimed spleen cell populations recognize macrophage-botund antigen see Vasopressin with opposite net electric charge, 1693 Antigen Antigen, nuclear see also Alloantigen Transient induction of nuclear antigen unrelated to Epstein-Barr Antigen, adrenal medullary nuclear antigen in cells of two human B-lymphoma lines coonvertedby Specific neural and adrenal medullary antigens detected by antisera to Epstein-Barr virus, 363 clonal PC12 pheochromocytoma cells, 5021 Antigen, p23,30 Antigen, A-like Proliferative and plaque-f'orming cell responses inhibited by human Isoantigenic expression of Forssman glycolipid in human gastric and bone-marrow-derived lymphocytes from peripheral blood by antisera colonic mucosa: Possible identity with "A-like antigen" in human to p23,30 antigen, 711 cancer, 3023 Antigen, T Antigen binding see Antigen, tumor Long-range conformational change induced by antigen binding to IgM Antigen, Thy 1.2 antibody, 5682 Thymopoietin and thymic hormone levels in human plasma: Bioassay Physiological regulation of antigen binding to T cells: Role of soluble determinations, 2541 macrophage factor and of interferon, 5662 Antigen, transplantation Antigen, blood-group Cytolytic thymus-derived lymphocytes specific ftorallogeneic stimulator Conversion of incomplete antibodies to direct agglutinins by mild cells crossreact with chemically modified syngeneic cells, 1229 reduction: Segmental flexibility within Fc fragment of Simian virus 40-specific proteins in membranes of simian virus immunoglobulin G, 2531 40-transformed hamster and mouse cells, 5069 Defects of glycosyltransferase activities in human fibroblasts of pk and p Antigen, tumor blood group phenotypes, 5407 Assignment of integration site for simian virus 40 to chromosome 17 in Antigen, cell membrane GM54VA, a human cell line transformed by simian virus 40, 315 Feline oncornavirus-associated cell membrane antigen: Immunologically Cell-free translation of simian virus 40 early messenger RNA coding for crossreactive feline sarcorna virus-coded protein, 5608 viral T-antigen, 457 Antigen, cell surface Feline oncornavirus-associated cell-membrane antigen (FOCMA): Moloney leukemia virus-induced cell surface antigen: Detection and Distinction between FOCMA and the major virion glycoprotein, 1219 characterization in sodium dodecyl sulfate gels, 5270 Helper factor(s) for growth of adeno-associated virus in cells transformed Specific neural and adrenal medullary antigens detected by antisera to by adenovirus 12, 4508 clonal PC12 pheochromocytoma cells, 5021 Identification of simian virus 40 tumor and U antigens, 447 Surface antigen in early differentiation, 4449 Moloney leukemia virus-induced cell surface antigen: Detection and Surface differentiation antigens of human mammary epthelial cells characterization in sodium dodecyl sulfate gels, 527(0 carried on human milk fat globule, 582 Polyoma virus T antigen: Characterization, 1259 Antigen, complement-fixing Purified complement-fixing antigen identified as Epstein-Barr Purified complement-fixing antigen identified as Epstein-Barr virus-determined nuclear antigen by its binding to metaphase virus-determined nuclear antigen by its binding to metaphase chromosomes, 1605 chromosomes, 1605 RNA synthesis in isolated nuclei stimulated by partially purified Antigen, C-type viral preparations of simian virus 40 T-antigen, 3189 Natural human antibodies reactive with primate type-C viral antigens, Simian virus 40 tumor antigen purified from a line of simian virus 1237 40-transformed human cells, 3745 Antigen, e Transformation by simian virus 40 induces virus-specific, related Association of e antigen with Dane particle DNA in sera from antigens in surface membrane and nuclear envelope, 2495 asymptomatic carriers of hepatitis B surface antigern, 2149 Tumorigenicity of simian virus 40-transformed human cells and Host specificity of serum marker for hepatitis B: "e antigen" has mouse-human hybrids in nude mice, 1142 properties of an immunoglobulin, 1702 Virus-specific proteins in plasma membrane of cells lytically infected or Antigen, Epstein-Barr virus-determined transformed by polyoma virus, 4666 Purified complement-fixing antigen identified as Epstein-Barr Antigen, tumor-associated virus-determined nuclear antigen by its binding to metaphase Development of tumor cell resistance to syngeneic cell-mediated chromosoomes, 1605 cytotoxicity during growth of ascitic mastocytoma P815Y, 329 Antigen, feline oncornavirus-associated cell-membrane Antigen, U Feline oncornavirus-associated cell-membrane antigen (FOCMA): Identification of simian virus 40 tumor and U antigens, 447 Distinction between FOCMA and the major virion glycoprotein, 1219 Simian virus 40-specific proteins in membranes of simian virus Feline oncornavirus-associated cell membrane antigen: Immunologically 40-transformed hamster and mouse cells, 5069 crossreactive feline sarcoma virus-coded protein, 5608 Transformation by simian virus 40 induces virus-specific, related Antigen, fibroblast surface antigens in surface membrane and nuclear envelope, 2495 see Fibrinectin Antigen, viral Antigen, Forssman Immunologic selection against simian virus-40 transformed cells: Isoantigenic expression of Forssman glycolipid in human gastric and Concomitant loss of viral antigens and early viral gene sequences, 4796 colonic mucosa: Possible identity with "A-like antigen" in human Antigen, viral hemagglutinin cancer, 3023 Specificity studies on cytotoxic thymus-derived lymphocytes reactive Antigen, group-specific with influenza virus-infected cells: Dual recognition of H-2 and viral Cell-free synthesis of precursor polypeptide for avian myeloblastosis hemagglutinin antigens, 3006 virus DNA polymerase, 4951 Downloaded by guest on September 27, 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Antihemophilic factor Aromatic L-amino-acid decarboxylase (EC 4.1.1.28) Macromolecular Factor VIII complex: Functional and structural Role of ecdysone, pupariation factors, and cyclic AMP in f'ormation and heterogeneity observed in von Willebrand swine with transfusion, 759 tanning of puparium of fleshfly Sarcophaga bullata, 4697 Antipain Arsenazo III Antipain and leupeptin restrict uterine DNA synthesis and function in Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in mice, 3754 liposomes, 1580 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Artemia salina prevents X repressor inactivation, ultraviolet mutagenesis, and Translational control by protein kinases in Artemia salina and wheat filamentous growth, 1152 germ, 4356 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Arthritis prevents X repressor inactivation, ultraviolet mutagenesis, and Collagen synthesis by chondrocytes in suspension culture: Modulation by filamentous growth (correction), 2594 calcium, 3':5'-cyclic AMP, and prostaglandins, 3864 Antiserum against interferon Arthropod Inhibition by anti-interferon serum of lymphocytic choriomeningitis Characterization and synthesis of volatile compounds for defensive virus disease in suckling mice, 2135 secretions of "daddy longlegs" (Arachnida: Opiliones: Leiobunum Antiserum, allo- spp.), 419 Reduction of syngeneic tumor growth by anti-I-J alloantiserum, 511.8 Arylamine acetyltransferase (EC 2.3.1.5) Antithrombin III Pineal protein phosphorylation during serotonin N-acetyltransferase Correlation of clotting protease activity in vitro and in viuo: Effect of induction, 1928 heparin, 3028 Arylhydrazine a-l-Antitrypsin Ligands and oxidants in ferrihemochrome formation and oxidative Specific lysine labeling by 18OH- during alkaline cleavage of hemolysis, 2556 o(-l -antitrypsin-trypsin complex, 4311 Ascitic mastocytoma P815Y Antitubulin Development of tumor cell resistance to syngeneic cell-mediated Antitubulins affect redistribution of crosslinked receptors on surface of cytotoxicity during growth of ascitic mastocytoma P81SY, 329 fibroblasts and epithelial cells, 2865 Ascomycetes Anxiety Major protein associated with fruiting body development in Neurospora Effects of naloxone on experimentally induced ischemic pain and on and related ascomycetes, 3831 mood in human subjects, 1291 Ascorbate Aorta Dependence of differentiated state on cellular environment: Modulation Biosynthesis of type I and III collagens by cultured smooth muscle cells of collagen synthesis in tendon cells, 4453 from human aorta, 671 Asparagine Different contractile mechanisms for angiotensin II and Enzyme regulation in neuroblastoma cells in a salts/glucose medium: des-Aspl-angiotensin II in rabbit aortic strips, 5725 Induction of ornithine decarboxylase by asparagine and glutamine, Regenerated endothelium affects lipid accumulation in arterial wall, 1724 3791 Apamin Asparagine synthetase (EC 3.6.1.1) Internal structural controls for evaluation of inactive synthetic peptide Asparaginyl-tRNA in regulation of asparagine synthetase in a analogs: Synthesis of [Ornl3,14]apaminand its guanidination to an mammalian cell line, 2367 apamin derivative with full neurotoxic activity, 2771 Asparaginyl-tRNA synthetase (EC 6.1.1.22) Apidae see also Aminoacyl tRNA synthetases Dual origin of highly social behavior among bees, 1135 Asparaginyl-tRNA in regulation of asparagine synthetase in a Aplysia californica mammalian cell line, 2367 Aplysia californica: Development of nervous system, 375 Aspartate carbamoyltransferase (EC 2.1.3.2) Facilitation at neuromuscular junctions: Contribution to habituation and Analytical and graphical examination of strong binding by half-of-sites dishabituation of Aplysia gill withdrawal reflex, 1267 in proteins: Illustration with aspartate transcarbamylase, 4959 Apolipoprotein Interaction of tetraiodofluorescein with a modified form of aspartate Activation of lipoprotein lipase by native and synthetic fragments of' transcarbamylase, 111 human plasma apolipoprotein C-II, 4848 Ligand-promoted weakening of intersubunit bonding domains in Amyloid protein SAA is associated with high density lipoprotein from aspartate transcarbamoylase, 3777 human serum, 4025 Aspartate transcarbamylase Intestine as a source of apolipoprotein A1, 2569 see Aspartate carbamoyltransferase Lipoprotein lipase cofactor activity of a carboxyl-terminal peptide of Aspirin apolipoprotein C-II, 5358 Alternative aspirins as antisickling agents: Acetyl-3,5-dibromosalicylic Primary structure of very low density apolipoprotein C-Il of human acid, 5499 plasma, 1942 Astrocytoma Solubilization of apolipoprotein B and its specific binding by cellular Polypeptide synthesis initiated with various NH2-blocked receptor for low density lipoprotein, 51.50 aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5909 Applied Mathematical Sciences Astronomy Absorbing boundary conditions for numerical simulation of waves, 1765 Chemical compositions of Magellanic Clouds' HII regions based on Subthreshold solutions of the Hodgkin-Huxley equations, 5199 photoelectric spectrophotometry, 5203 Applied Physical and Mathematical Sciences Discrete spiral modes in disk galaxies: Numerical examples based on General variational principles applicable to the hybrid element method, density wave theory, 4726 2595 Galaxies: Outstanding problems and instrumental prospects for the Method of computational magnetohydrodynamics defining stable Scyllac coming decade (Review), 1767 equilibria, 393 Atherosclerosis Structure deternmination of gaseous and amorphous substances by Radioimmunoassay of human serum growth factor for Balb/c-3'I'3 cells: diffraction methods: Philosophical concepts and their implementation Derivation from platelets, 1973 (Review), 4707 Regenerated endothelium affects lipid accumulation in arterial wall, 1724 Theory of connectivity for formally symmetric operators, 4722 Atomic diffusion Weather modification technology: Statistician's view (Review), 4714 Direct observations of atomic diffusion by scanning transmission Arabacia punctulata electron microscopy, 1802 Histone and DNA synthesis: Noncoincidence in cleavage cycles of early Atom motion development, 5016 Direct observations of atomic diffusion by scanning transmission L-Arabinose electron microscopy, 1802 Nucleotide sequence of 5' end of araBAD operon messenger RNA in ATP phosphoribosyltransferase (EC 2.4.2.17) Escherichia coli B/r, 49 Inhibition of histidyl-tRNA-adenosine triphosphate Arachidonic acid phosphoribosyltransferase complex formation by histidine and by Imidazole: Selective inhibitor of' thromboxane synthetase in human guanosine tetraphosphate, 1535 platelets, 1716 ATP sulfurylase Inhibition of human platelet thromboxane synthetase by see Sulfate adenylyltransferase 9,11-azoprosta-5,13-dienoic acid, 4007 Autointerference Novel prostaglandin is major product of arachidonic acid metabolism in 3' Terminus of RNA isolated from vesicular stomatitis virtus and frormits rabbit heart, 101 defective interfering particles, 1353 Precursor role of arachidonic acid in release of slow reacting substance Autonomic nervous system from rat basophilic leukemia cells, 4577 Centers involved in autonomic reflex reactions originating from Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin stretching of the atria, 2177 methyl ester: Comparison with endoperoxides and other prostanoids, Auxotroph 5711 Defined minimal medium for axenic strains of I)ictyostelium Archaebacteria discoideum, 2157 Phylogenetic structure of prokaryotic domain: Primary kingdoms, 5088 Avena sativa Arenivaga investigata Organic acid and potassium accumulation in guard cells during stomatal Site of water vapor absorption in desert cockroach, Arenivaga opening, 4439 investigata, 1757 Avian leukosis virus Arginine Envelope-glycoprotein messenger activities of avian leukosis viral RNAs: Steroidogenic activity of fragments of adrenocorticotropin with arginine Microinjection analysis, 1614 in residue positions 3 and 5, 4329 Avian myeloblastosis virus Cell-free synthesis of precursor polypeptide for avian myeloblastosis virus DNA polymerase, 4951 Downloaded by guest on September 27, 2021 5788 Subject Index Proc. 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Frog oocytes synthesize and completely process precursor polypeptide to Inactivation and proteolytic cleavage of phage X repressor in vitro in an virioonstructural proteins after microinjection of avian myeloblastosis ATP-dependent reaction, 2283 virus RNA, 3230 Initiation of genetic exchanges in X phage-prophage crosses, 291 Single-stranded DNA from oncornavirus-infected cells enriched in Integration protein of bacteriophage X is a site-specific DNA-binding virus-specific DNA sequences, 3720 protein, 1511 Synthesis of full-length DNA copies of avian myeloblastosis virus RNA Mutant of Escherichia coli showing constitutive expression of lysogenic in high yields, 2840 induction and error-prone DNA repair pathways, 300 tRNA' r) (bovine) binding to reverse transcriptase of avian Packaging recombinant DNA molecules into bacteriophage particles in myeloblastosis virus and function as a heterologous primer, 1889 vitro, 3259 Avidin Ribosomal mutations affect read-through of chain termination signal: Biotinylisnsulins as potential tools for receptor studies, 2697 Synthesis of bacteriophage X 0 gene protein in vitro, 689 Axon RNA polymerase binding sites in Xplac5 DNA, 4914 see also Membrane, axonal; Nerve; Neuron Specialized transducing phage for initiation factor 3 gene in Escherichia Cholinergic ligands and local anesthetics interact with plasma membrane coli, 3970 fragments from lobster axon, 2278 State of prophage Mu DNA upon induction, 3143 Axoneme Bacteriophage XpolA Cilia: Active role in sensory transduction, 793 Isolation and characterization of XpolA transducing phage, 5632 I)ynein identified as outer arms of sea urchin sperm axonemes, 5006 Bacteriophage M13 Azaserine Filamentous coliphage M13 as cloning vehicle: Insertion of HindIIl Affinity labeling of -y-glutamyl transpeptidase and location of ^y-glutamyl fragment of lac regulatory region in M13 replicative form in vitro, binding site on light subunit, 931 3642 Membrane-associated assembly of M13 phage in extracts of virus-infected Escherichia coli, 505 Bacillus brevis Bacteriophage Mu Iliological function of gramicidin: Gramicidin-negative mutants, 780 State of prophage Mu DNA upon induction, 3143 Isolation of amino acid activating subunit-pantetheine protein Bacteriophage N4 complexes: Role in chain elongation in tyrocidine synthesis, 2343 Virion-associated RNA polymerase required for bacteriophage N4 Bacillus cereus development, 520 Spore coat processing and protein turnover altered in a Bacillus cereus Bacteriophage P1 mutant with a defective postexponential intracellular protease, 1254 Conditionally lethal ribosomal protein mutants: Locus required for Bacillus circulans modification of 50S subunit proteins, 467 Aminoglycoside-modifying enzyme of antibiotic-producing bacterium Recombinant plasmid that carries part of nitrogen fixation (nif) gene acts as determinant of antibiotic resistance in Escherichia coli, 999 cluster of Klebsiella pneumoniae, 2963 Bacillus megaterium Bacteriophage PM2 Rapid transmembrane movement of newly synthesized phospholipids Mapping of closed circular DNAs by cleavage with restriction during membrane assembly, 1821 endonucleases and calibration by agarose gel electrophoresis, 851 Bacillus subtilis Bacteriophage P2sig5 Control of development: Isolation of Bacillus subtilis mutants blocked Terminus region of chromosome in Escherichia coli inhibits replication early in sporulation and defective in synthesis of highly forks, 3927 phosphorylated nucleotides, 1125 Bacteriophage Qf Penicillin-binding peptide isolated from D)-alanine carboxypeptidase of Escherichia coli mutant with temperature sensitive function affecting Bacillus subtilis, 1009 bacteriophage Q?l RNA replication, 1657 Replication and expression of plasmids from Staphylococcus aureus in Escherichia coli ribosomal protein S1 has two polvnucleotide binding Bacillus subtilis, 1,680 sites, 4786 Sensory electrophysiology of bacteria: Relationship of membrane Ribosomal mutations affect read-through of chain termination signal: potential to motility and chemotaxis in Bacillus subtilis, 4752 Synthesis of bacteriophage X 0 gene protein in vitro, 689 Bacterial conjugation Bacteriophage ST-1 Cell-cell interactions in conjugating Escherichia coli: Role of traT DNA or RNA priming of bacteriophage G4 DNA synthesis by protein in surface exclusion, 5104 Escherichia coli dnaG protein, 2815 Bacteriophage Bacteriophage T3 Bacteriophage system for screening and study of biologically active Ribonuclease III cleavage of bacteriophage T3 RNA polymerase polycyclic aromatic hydrocarbons and related compounds, 1378 transcripts to late T3 mRNAs, 4891 Bacteriophage skX174 Bacteriophage T4 Bacteriophage q,X174: Gene A overlaps gene B, 2504 2-Aminopurine-induced mutagenesis in T4 bacteriophage: Model relating Cleavage specificity of restriction endonuclease isolated from mutation frequency to 2-aminopurine incorporation in DNA, 4806 Haemophilus gallinarum (Hga I), 3213 Bacteriophage T4 RNA ligase is gene 63 product, the protein that D)iscontinuous replication of replicative form DNA from bacteriophage promotes tail fiber attachment to baseplate, 3355 (/)X174, 2776 Dinucleoside pyrophosphates are substra'tes for T4-induced RNA ligase. DNA sequencing with chain-terminating inhibitors, 5463 4839 Mechanism of duplex DNA replication revealed by enzymatic studies of' DNA packaging and pathway of bacteriophage T4 head assembly, 3652 phage (/X174: Catalytic strand separation in advance of replication, Enzyme associations in T4 phage DNA precursor synthesis, 3152 193 Method for localizing proteins in periodic structures: Fab fragment Mechanism of phage (pX174 DNA inactivation by labeling combined with image processing of electron micrographs, 5514 benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, 3335 Phage T4-modified RNA polymerase transcribes T4 late genes in vitro, Migratiosn of Escherichia coli dnaB protein on template DNA strand as 5305 mechanism in initiating DNA replication, 4190 Bacteriophage T7 Nucleic acid reassociation kinetics: Rate of hybridization of excess RNA Electron microscope studies of transient complexes formed between with DNA, compared to rate of DNA renaturation, 1020 Escherichia coli RNA polymerase holoenzyme and T7 DNA, 3740 NuLcleicacid reassociation kinetics: Retarded rate of hybridization of Nucleotide sequence from a ribonuclease III processing site in RNA with excess DNA, 2306 bacteriophage T7 RNA, 822 Role of DNA gyrase in q)X replicative-form replication in vitro, 1965 Nucleotide sequence surrounding a ribonuclease III processing site in (/X174 cistron A protein is a multifunctional enzyme in DNA replication, bacteriophage T7 RNA, 984 :3198 Replication of duplex DNA by bacteriophage T7 DNA polymerase and Synthesis of (X174 viral DNA in vitro depends on OX replicative f'orm gene 4 protein is accompanied by hydrolysis of nucleoside I)NA, 4195 5'-triphosphates, 1525 Thermostable sequence-specific endonuclease from Thermus aquaticus, Structure of promoter for T7 RNA polymerase, 4266 542 Bacteriorhodopsin Bacteriophage fl see also Rhodopsin Interaction of rabbit reticulocyte ribosomes with bacteriophage fl Isolation of chloroplast N,N'-dicyclohexylcarbodiimide-binding mRNA and of Escherichia coli ribosomes with rabbit globin mRNA, proteolipid, active in proton translocation, 2375 2692 Molecular weight of bacteriorhodopsin solubilized in Triton X-100, 2803 Nucleotide sequences near origin of replication of bacteriophage fl, 4219 Orientation of bacteriorhodopsin in Halobacterium halobium studied by Bacteriophage fd selective proteolysis, 5426 Enzymatic initiation of DNA synthesis by yeast DNA polymerases, 1937 Time-resolved resonance Raman spectroscopy of bacteriorhodopsin on Bacteriophage G4 the millisecond timescale, 5212 I)NA or RNA priming of bacteriophage G4 DNA synthesis by Bacterium, peritrichously flagellated Escherichia coli dnaG protein, 2815 Bacterial flagella rotating in bundles: Study in helical geometry, 221 Bacteriophage A Barth-Lefschetz theorem see also Prophage \ Theorems of Barth-Lefschetz type for complex subspaces of Assembly of biologically active proheads of bacteriophage lambda in homogeneous complex manifolds, 1332 vitro, 906 Base pair Cloning specific segments of mammalian genome: Bacteriophage X Hydrogen-bonded proton in tertiary structure of yeast tRNA'he in containing mouse globin and surrounding gene sequences, 4406 solution, 1561 Identification of spacer tRNA genes in individual ribosomal RNA Netropsin-poly(dA-dT) complex in solution: Structure and dynamics of transcription units of Escherichia coli, 2710 antibiotic-free base pair regions and those centered on bound Identification of spacer tRNA genes in individual ribosomal RNA netropsin, 5207 transcription units of Escherichia coli (correction), 4706 Basis Differentiation of integrals, 2211 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5789

Batrachotoxin Electron microscopy of fibers and discs of hemoglobin S having sixfold Batrachotoxinaffects electroplaxof electric eel: Voltage-dependent symmetry, 5538 interactionwith sodiumchannels, 951 Electron microscopy of negatively stained and freeze-etched high density Bayes method lipoprotein-3 from human serum, 5001 CompoundPoisson distribution:Prediction and estimation,2670 Electron paramagnetic resonance studies of photosynthetic electron Bedload transport: Photoreduction of ferredoxin and membrane-bound 1976 Bedload measurements,East Fork River,Wyoming, 2644 iron-sulfur centers, 3826 Beetle Electron spin resonance absorption of tissue constituents, 1558 see Plagiodera vesicolora Electron transfer: Experimental verification of vibronically coupled Behavior electron tunneling, 3817 Active touch explorationof extrapersonalspace elicits specific Flexibility of myosin rod, light meromyosin, and myosin subfragment-2 in electrogenesisin right cerebralhemisphere of intact right-handedman, solution, 4986 4037 Hydrogen-bonded proton in tertiary structure of yeast tRNAPhe in Behavior-geneticanalysis of Phormiaregina: Conditioning, reliable solution, 1561 individualdifferences, and selection,5193 Kinetics of alkaline tetramer to dimer dissociation in liganded human Brain protein metabolismand acquisitionof new patternsof behavior, hemoglobin: Laser light-scattering stopped-flow study, 3814 1743 Lecithin bimolecular leaflets: Nuclear magnetic resonance studies with ?-Endorphin:Development of toleranceand its reversalby incorporated fluorescent probes, 1032 5-hydroxytryptophanin cats, 4017. Ligand kinetics of hemoglobin S containing erythrocytes, 203 Sensorytransduction in Escherichiacoli: Role of proteinmethylation Light collection and harvesting processes in bacterial photosynthesis reactionin sensoryadaptation, 4964 investigated on picosecond time scale, 1997 Behavior,social Lipid vesicles in vivo: Gamma-ray perturbed angular correlation study, Dual originof highly social behavioramong bees, 1135 4991 Benz[a]anthracene Living state and cancer, 2844 Bacteriophagesystem for screeningand study of biologicallyactive Microtubule structure at low resolution by x-ray diffraction, 3370 polycyclicaromatic hydrocarbons and related compounds,1378 Molecular events and energy changes during action potential, 3810 Mutagenicityand cytotoxicityof benz[a]anthracenediol epoxides and Nuclear coupling of 33S and nature of free radicals in irradiated crystals tetrahydro-epoxides:Exceptional activity of bay region 1,2-epoxides, of N-acetyl-L-cysteine, 216 2746 Physical-chemical approach to transient change in Na ion conductivity Tumorigenicityof five dihydrodiolsof benz[a]anthraceneon mouse skin: of excitable membranes (correction), 3621 Exceptionalactivity of benz[a]anthracene3,4-dihydrodiol, 3176 31P nuclear magnetic resonance measurements of ATPase kinetics in Benz[a]anthracene,7,12-dimethyl- aerobic Escherichia coli cells, 5551 Histopathogenesisof 7,12-dimethylbenz[a]anthracene-inducedrat Proton spin-lattice relaxation of retinal rod outer segment membranes mammarytumors, 4020 and liposomes of extracted phospholipids, 1978 Benzene Quantum efficiency of photosynthetic energy conversion, 3377 Electrophilicmercuration and thallationof benzeneand substituted Random walk analysis of potassium fluxes associated with nerve benzenesin trifluoroaceticacid solution,4121 impulses, 5543 Benzo[a]pyrene Rhodopsin in model membranes: Charge displacements in interfacial Bacteriophagesystem for screeningand study of biologicallyactive layers, 207 polycyclicaromatic hydrocarbons and related compounds,1378 Ribulose-1,5-bisphosphate carboxylase-oxygenase structure: Form III Excisionrepair of benzo[a]pyrene-deoxyguanosineadducts in baby crystals, 1037 hamsterkidney 21/C13cells and in secondarymouse embryo Sensitivity, polarity, and conductance change in response of vertebrate fibroblastsC57BL/6J, 979 hair cells to controlled mechanical stimuli, 2407 Majoradducts formedby reactionof benzo[a]pyrenediol epoxide with Simultaneous measurements of viscosity and density in solutions DNA in vitro, 5285 undergoing change, 4430 Mechanismof phage <1X174DNA inactivationby Solid-like character of virus solutions, 1993 benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide,3335 Solid tumor models for assessment of different treatment modalities: Quantitativedetermination of transformedcells in a mixed population Therapeutic strategy for sequential chemotherapy with radiotherapy, by simultaneousfluorescence analysis of cell surfaceand DNA in 1983 individualcells, 1626 Stereochemical trigger that initiates cooperative interaction of Benzoate hemoglobin subunits: Emission Mossbauer study, 4996 Model for "charge-relay":Acceleration by carboxylateanion in Structure of gramicidin A channel: Discrimination between srL,Dand / intramoleculargeneral base-catalyzed ester hydrolysisby imidazolyl helix by electrical measurements with lipid bilayer membranes, 2402 group,2634 Structure of human plasma low-density lipoproteins: Molecular Benzodiazepine organization of central core, 1042 Specific benzodiazepinereceptors in rat brain characterizedby Surface localization of sites of reduction of nitroxide spin-labeled high-affinity[3H]diazepam binding, 3805 molecules in mitochondria, 570 Bile acid Transmembrane movement of cholesterol in human erythrocytes, 1538 Hepatic mitochondrialcytochrome P-450: Isolationand functional Tripartite model for photochemical apparatus of green plant characterization,5477 photosynthesis, 3382 Bindin Unified mechanism for relay and oscillation of cyclic AMP in Isolationof bindin:Protein responsiblefor adhesionof spermto sea Dictyostelium discoideum, 1543 urchineggs, 2456 Vibronically coupled tunneling description of biological electron transfer: Bioelectricity Experimental test, 229 Bioelectricityand regeneration:Large currents leave stumps of X-ray absorption edge studies on oxidized and reduced cytochrome c regeneratingnewt limbs, 4528 oxidase, 3821 Bioenergetics Biotin High-resolution31P nuclear magnetic resonance studies of metabolismin Biotinylinsulins as potential tools for receptor studies, 2697 aerobicEscherichia coli cells, 888 Biparental model Biohazard Generalizing Fisher's "reproductive value": Nonlinear, homogeneous, Replicationand expressionof plasmidsfrom Staphylococcusaureus in biparental systems, 5772 Bacillus subtilis, 1680 4,4'-Bis(1-anilinonaphthalene 8-sulfonate) Biologicalclock 4,4'-Bis(1-anilinonaphthalene 8-sulfonate): Probe of active site of see also Circadianrhythm myosin, 2334 Heavy water as a tool for study of forcesthat controllength of periodof Blastocyst the 24-hourclock of hamsters,1295 Mosaic mice with teratocarcinoma-derived mutant cells deficient in Bioluminescence hypoxanthine phosphoribosyltransferase, 5564 Structureof native Renilla reniformisluciferin, 4285 Blood Biophysics Defects of glycosyltransferase activities in human fibroblasts of pk and p Bacterialflagella rotating in bundles:Study in helical geometry,221 blood group phenotypes, 5407 Calcium-inducedluminescence of aequorin:Reversible and irreversible Glycolipid-bound sialic acid in serum: Increased levels in mice and inhibitionby anesthetics,5534 humans bearing mammary carcinomas, 3011 l3C nuclearmagnetic resonance studies of radiationdamage: Proliferative and plaque-forming cell responses inhibited by human Radiation-induceddegradation of glycine, 2394 bone-marrow-derived lymphocytes from peripheral blood by antisera Contrastvariation study of specificallydeuterated Escherichia coli to p23,30 antigen, 711 ribosomalsubunits, 5547 Blood coagulation Density of sodium channels in mammalian myelinated nerve fibers and see also specific factors natureof axonal membraneunder myelin sheath, 211 Activationof FactorIX by reactionproduct of tissue factor and Factor Differencesin removalof acetylaminofluoreneand pyrimidinedimers VII: Additionalpathway for initiatingblood coagulation,5260 from DNA of culturedmammalian cells, 1553 Aminoacid sequenceof humanprothrombin fragments 1 and 2, 1969 Differentrate-limiting steps in excisionrepair of ultraviolet-and Correlationof clotting proteaseactivity in vitro and in vivo:Effect of N-acetoxy-2-acetylaminofluorene-damagedDNA in normalhuman heparin,3028 fibroblasts,1548 Interactionof coagulationfactor Xa with humanplatelets, 4033 Dynamicstructure of whole cells probedby nuclearOverhauser Blood group enhancednitrogen-15 nuclear magnetic resonance spectroscopy, 1988 see also Antigen,blood-group Elastic model of supercoiling,2397 Isoantigenicexpression of Forssmanglycolipid in humangastric and Electronicallyexcited retinal,3375 colonic mucosa:Possible identity with "A-likeantigen" in human Electronicproperties of casein-methylglyoxalcomplex, 226 cancer,3023 Downloaded by guest on September 27, 2021 5790 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Waldenstrom macroglobulin that is a cold agglutinin and a cryoglobulin Neurotensin: Specific binding to synaptic membranes from rat brain, because it binds N-acetylneuraminosyl residues, 4591 1846 Blood, peripheral Opiate receptor: Cooperativity of binding observed in brain slices, 5764 Characterization of an erythroid precursor cell of high proliferative Regional dissociation of /-endorphin and enkephalin contents in rat capacity in normal human peripheral blood, 1105 brain and pituitary, 5162 Blood pressure Specific benzodiazepine receptors in rat brain characterized by Reduction of blood pressure and vascular collagen in hypertensive rats high-affinity [3H]diazepam binding, 3805 by ?-aminopropionitrile, 360 Stoichiometry of GTP hydrolysis and tubulin polymerization, 462 Body composition Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit Carcass components at first estrus of rats on high-fat and low-fat diets: synthesis of brain-specific protein in rat glial cells, 3855 Body water, protein, and fat, 379 Troponin-like complex isolated from bovine brain cortex, 2273 Bombyx mori Vasoactive intestinal polypeptide in brain: Localization in and release Cloning of silk fibroin gene and its flanking sequences, 5363 from isolated nerve terminals, 3424 Bonding domain Brevibacterium ammoniagenes Ligand-promoted weakening of intersubunit bonding domains in Fatty acid synthetase from Brevibacterium ammoniagenes: Formation of' aspartate transcarbamoylase, 3777 monounsaturated fatty acids by multienzyme complex, 3180 Bone Brome mosaic virus Immunological defect and its correction in osteopetrotic mutant rat, 339 Loss of infectivity of brome mosaic virus RNA after chemical Transitions in collagen types during matrix-induced cartilage, bone, and modification of 3' or 5' terminus, 2682 bone marrow formation, 5589 Sequence of oligonucleotide derived from 3' end of each of the four Bone marrow brome mosaic viral RNAs, 4900 Antibody affinity enhanced in sublethally irradiated mice and bone a-Bungarotoxin marrow chimeras, 707 Histrionicotoxin enhances agonist-induced desensitization of In vivo analysis of cellular replication, 2041 acetylcholine receptor, 5754 Terminal deoxynucleotidyltransferase: Intracellular distribution in rat Immunological distinction between acetylcholine receptor and bone marrow and thymus, 3993 a-bungarotoxin-binding component on sympathetic neurons, 4689 Transitions in collagen types during matrix-induced cartilage, bone, and Synaptic acetylcholine receptor sites identified in retina with bone marrow formation, 5589 peroxidase-labeled sc-bungarotoxin, 3268 Boride, ternary Crystallography of new ternary borides, 1336 Crystallography of new ternary borides (correction), 3621 Caenorhabditis elegans High superconducting transition temperatures of new rare earth ternary Internal deletion mutant of a myosin heavy chain in Caenorhabditis borides, 1334 elegans, 5336 Born-Oppenheimer state Calabi's conjecture Radiationless relaxation in "large" molecules: Preparation of true Calabi's conjecture and some new results in algebraic geometry, 1798 molecular eigenstates and Born-Oppenheimer states by a coherent Calcitonin light source, 1310 Calcitonin: Its hormonal action on gill, 4693 Boron Calcium i3C nuclear magnetic resonance study of five- and six-coordinated carbon Action potentials occur in cells of normal anterior pituitary gland and in nonclassical organometallic compounds: Dimeric trialkyl-, are stimulated by hypophysiotropic peptide thyrotropin-releasing tricyclopropyl-, and triarylaluminums and some nido and closo hormone, 4064 carboranes, 5217 Calcitonin: Its hormonal action on gill, 4693 Botany Calcium-binding protein of chorioallantoic membrane: Identification and Cell wall extension in Nitella as influenced by acids and ions, 1565 developmental expression, 1946 Chlorophyll b identified in extracts of prokaryotic algae by fluorescence Calcium control of actin-activated myosin adenosine triphosphatase from spectroscopy, 575 Dictyostelium discoideum (correction), 392 125I-labeled phytochrome used to quantitate phytochrome binding to Calcium dependence of glucocorticoid-induced lymphocytolysis, 638 membranes of Avena sativa, 4439 Calcium-induced luminescence of aequorin: Reversible and irreversible Major protein associated with fruiting body development in Neurospora inhibition by anesthetics, 5534 and related ascomycetes, 3831 Calcium modulation in brain extracellular microenvironment Organic acid and potassium accumulation in guard cells during stomatal demonstrated with ion-selective micropipette, 1287 opening, 4434 Calcium translocation by Golgi and lateral-basal membrane vesicles from Promotion and inhibition of flower formation in a dayneutral plant in rat intestine: Decrease in vitamin D-deficient rats, 3612 grafts with a short-day plant and a long-day plant, 2412 Collagen synthesis by chondrocytes in suspension culture: Modulation by Thermosensitive step associated with transfer of Ti plasmid during calcium, 3':5'-cyclic AMP, and prostaglandins, 3864 conjugation: Relation to transformation in crown gall, 2848 Complexes of inorganic pyrophosphate, orthophosphate, and calcium as Boundary, artificial stimulants of 3T3 cell multiplication, 5026 Absorbing boundary conditions for numerical simulation of waves, 1765 Different contractile mechanisms for angiotensin II and Boundary condition des-Aspl-angiotensin II in rabbit aortic strips, 5725 Absorbing boundary conditions for numerical simulation of waves, 1765 Dynamic properties of isolated acetylcholine receptor proteins: Release Analytic torsion and Reidemeister torsion, 2651 of calcium ions caused by acetylcholine binding (correction), 1763 Boundary, real-analytic pseudoconvex Effect of MgATP on stiffness measured at two frequencies in Complex submanifolds in real-analytic pseudoconvex hypersurfaces, 3126 Ca2+-activated muscle fibers, 4073 Boundary value problem Free calcium increases explosively in activating medaka eggs, 623 Pseudo-monotone operators and nonlinear elliptic boundary value lonophores stimulate prostaglandin and thromboxane biosynthesis, 4251 problems on unbounded domains, 2659 lonophores stimulate prostaglandin and thromboxane biosynthesis Brain (correction), 5778 see also Central nervous system; Cerebellum; Hypothalamus Magnesium and calcium effects on uptake of hexoses and uridine by Active touch exploration of extrapersonal space elicits specific chick embryo fibroblasts, 1585 electrogenesis in right cerebral hemisphere of intact right-handed man, Mitotic Ca 2--adenosinetriphosphatase: Synthesis and activation during 4037 cell cycle of mouse mastocytoma cells, 1610 Antagonism of histamine-activated adenylate cyclase in brain by Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during D-lysergic acid diethylamide, 5697 the cell cycle of mouse mastocytoma cells (correction), 3621 Brain dopamine receptors: Detection with [3H]dihydroergocryptine, 3750 Phosphorylation of smooth muscle myosin affects actin activation and Brain protein metabolism and acquisition of new patterns of behavior, Ca + regulation, 129 1743 Recessive dystrophic epidermolysis bullosa: Evidence for altered Calcium modulation in brain extracellular microenvironment collagenase in fibroblast cultures, 4646 demonstrated with ion-selective micropipette, 1287 Role of nucleotides in tubulin polymerization: Effect of guanylyl Chemical basis for brain-specific serine transfer RNAs, 4243 5'-methylenediphosphonate, 4881 Cholecystokinin and its COOH-terminal octapeptide in pig brain, 3035 Stimulus-secretion coupling in chromaffin cells isolated from bovine Corticotropin in brain of normal and hypophysectomized rats, 648 adrenal medulla, 5036 Embryonic chicken brain and mouse neuroblastoma cells NIE-115 and Sugar uptake and thymidine incorporation in mouse 3T3 cells stimulated N-18 contain an inhibitor of acid deoxyribonuclease, 842 by calcium phosphate and other extracellular particles, 5593 Explant cultures of catecholamine-containing neurons from rat brain: 'rroponin-like complex isolated from bovine brain cortex, 2273 Biochemical, histofluorescence, and electron microscopic studies, 4471 Voltage-dependent facilitation of Ca2+ entry in voltage-clamped, Food, drug, and cosmetic dyes: Biological effects related to lipid aequorin-injected molluscan neurons, 1748 solubility, 2914 Calcium phosphate Fructose-l,6-bisphosphatase in mammalian brain, 3222 Membrane ultrastructural changes during calcium phosphate-induced Guanosinetriphosphatase activity of tubulin associated with microtubule fusion of human erythrocyte ghosts, 2417 assembly, 5372 Cancer Immunohistochemical localization in rabbit brain of a peptide see also Carcinogenesis; specific cancers; specific cells resembling COOH-terminal octapeptide of cholecystokinin, 3033 Age incidence curves for cancer, 1341 In vitro assembly of pure tubulin into microtubules in absence of Antibodies to estrogen receptor: Immunochemical similarity of microtubule-associated proteins and glycerol, 1860 estrophilin from various mammalian species, 3681 /-Lipotropin: Localization of cells and axons in rat brain by Antibody to autologous human leukemia cells detected by immune immunocytochemistry, 5155 adherence assays, 4587 Neuronal actions of endorphins and enkephalins among brain regions: Antigenic relatedness of DNA polymerase of human breast cancer Comparative microiontophoretic study, 2584 particles to enzyme of Mason-Pfizer monkey virus, 2144 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5791

Cyclic AMP, microtubule-microfilament system, and cancer, 4491 GMP from induction of ornithine decarboxylase by tumor promoter DNA polymerase of human breast cancer particles: Purification and 12-0-tetradecanoyl phorbol-13-acetate in mouse epidermis in uivo, 657 characterization, 764 Dissociation of tumor promoter-stimulated ornithine decarboxylase Electron spin resonance absorption of tissue constituents, 1558 activity and DNA synthesis in mouse epidermis in vivo and in vitro by Glycolipid-bound sialic acid in serum: Increased levels in mice and fluocinolone acetonide, a tumor-promotion inhibitor, 3908 humans bearing mammary carcinomas, 3011 Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby Histopathogenesis of 7,12-dimethylbenz[a]anthracene-induced rat hamster kidney 21/C13 cells and in secondary mouse embryo mammary tumors, 4020 fibroblasts C57BL/6J, 979 Living state and cancer, 2844 Histopathogenesis of 7,12-dimethylbenz[a]anthracene-induced rat Mapping of human chromosomal regions related to neoplasia: Evidence mammary tumors, 4020 from chromosomes I and 17, 5729 Major adducts formed by reaction of benzo[a]pyrene diol epoxide with Multiple antigenic determinants on major surface glycoprotein of murine DNA in vitro, 5285 mammary tumor viruses, 3564 Mechanism of phage 0X174 DNA inactivation by Pterin-6-aldehyde, a cancer cell catabolite: Identification and application benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, 3335 in diagnosis and treatment of human cancer, 587 Mutagenicity and cytotoxicity of benz[a]anthracene diol epoxides and Rates of aggregation, loss of anchorage dependence, and tumorigenicity tetrahydro-epoxides: Exceptional activity of bay region 1,2-epoxides, of cultured cells, 258 2746 Rauscher-leukemia-virus-related sequences in human DNA: Presence in Partial inhibition of postreplication repair and enhanced frequency of some tissues of some patients with hematopoietic neoplasias and chemical transformation in rat cells infected with leukemia virus, 238 absence in DNA from other tissues, 353 Receptor protein of activated carcinogen, 2293 Rejection by syngeneic mice of cell variants obtained by mutagenesis of Specific changes in collagen phenotype of BALB 3T3 cells: Result of teratocarcinoma cell line, 272 transformation by sarcoma viruses or a chemical carcinogen, 2933 Solid tumor models for assessment of different treatment modalities: Structural identification of major DNA adduct formed by aflatoxin B1 in Therapeutic strategy for sequential chemotherapy with radiotherapy, vitro, 1870 1983 Tumorigenicity of five dihydrodiols of benz[a]anthracene on mouse skin: Surface differentiation antigens of human mammary epthelial cells Exceptional activity of benz[a]anthracene 3,4-dihydrodiol, 3176 carried on human milk fat globule, 582 Tumor promoters inhibit spontaneous differentiation of Friend Theories of quasi-linkage and "affinity": Implications for population erythroleukemia cells in culture, 2894 structure, 3513 Carcinogenesis, ultraviolet Tumorigenicity of simian virus 40-transformed human cells and Systemic alteration induced in mice by ultraviolet light irradiation and mouse-human hybrids in nude mice, 1142 its relationship to ultraviolet carcinogenesis, 1688 Cancer antennarius Stimpson Carcinus Secretion of a-ecdysone by crab Y-organs in vitro, 615 Effect of increased potassium concentrations on particle motion within a Candida lipolytica neurosecretory structure, 5759 Candida lipolytica mutants defective in acyl-coenzyme A synthetase: Cardiac control Isolation and fatty acid metabolism, 4947 Interaction of myogenic and neurogenic mechanisms that control heart Capping enzyme rate, 1761 Sites of transcription initiation in uivo on Xenopus laevis ribosomal Carnitine, acyl- DNA, 5402 Isolation and identification of aliphatic short-chain acylcarnitines from Carassius auratus beef heart: Role for carnitine in branched-chain amino acid Brain protein metabolism and acquisition of new patterns of behavior, metabolism, 2795 1743 Cartilage Carbohydrate Transitions in collagen types during matrix-induced cartilage, bone, and see also Cell-surface carbohydrate bone marrow formation, 5589 Oligosaccharides in human IgAl and IgA2 immunoglobulins: Location Casein and structural significance, 2301 Electronic properties of casein-methylglyoxal complex, 226 Carbon Hormonal effects on intracellular and secreted casein in cultures of 13C nuclear magnetic resonance study of five- and six-coordinated carbon mouse mammary epithelial cells on floating collagen membranes, 4466 in nonclassical organometallic compounds: Dimeric trialkyl-, Hormone-inducible casein messenger RNA in serum-free organ culture tricyclopropyl-, and triarylaluminums and some nido and closo of whole mammary gland, 2441 carboranes, 5217 Cat Carbonate dehydratase (EC 4.2.1.1) Effects of early experience upon orientation sensitivity and binocularity Carbonic anhydrase from the inner ear of guinea pig: Purification, 892 of neurons in visual cortex of cats, 1272 X-ray absorption studies of halide binding to carbonic anhydrase, 1794 /-Endorphin: Behavioral and analgesic activity in cats, 774 Carbon dioxide f-Endorphin: Development of tolerance and its reversal by Identification and cloning of chloroplast gene coding for large subunit of 5-hydroxytryptophan in cats, 4017 ribulose-l,5-bisphosphate carboxylase from Chlamydomonas Catabolic dehydroquinase reinhardi, 3193 see 5-Dehydroquinate dehydratase Source of oxygen in CO2 produced in bioluminescent oxidation of firefly Catalepsy luciferin, 2799 3-Endorphin: Pituitary and adrenal glands modulate its action, 4628 Carbonic anhydrase Catalysis see Carbonate dehydratase see also Enzyme catalysis 1,4 Carbon-sulfur interaction Unified picture of mechanisms of catalysis by carboxypeptidase A, 1303 Stable conformations of aliphatic disulfides: Influence of 1,4 interactions Catalysis, intramolecular general base involving sulfur atoms, 13 Intramolecular general base-catalyzed ester hydrolyses by imidazolyl Carborane group, 23 13C nuclear magnetic resonance study of five- and six-coordinated carbon Intramolecular general base-catalyzed ester hydrolyses by imidazolyl in nonclassical organometallic compounds: Dimeric trialkyl-, group (correction), 3621 tricyclopropyl-, and triarylaluminums and some nido and closo Catecholamine carboranes, 5217 Adenylate cyclase-free, /-adrenergic receptor isolated from turkey Carboxylate erythrocyte membranes by affinity chromatography, 3710 Model for "charge-relay": Acceleration by carboxylate anion in Adenylate cyclase permanently uncoupled from hormone receptors in intramolecular general base-catalyzed ester hydrolysis by imidazolyl novel variant of S49 mouse lymphoma cells, 2016 group, 2634 Biogenic amine-ionophore interactions: Structure and dynamics of Selective recognition of nucleic acids by proteins: Specificity of guanine lasalocid (X537A) complexes with phenethylamines and interaction with carboxylate ions, 4872 catecholamines in nonpolar solution, 4734 Carboxyl group Catecholamine binding to 0-adrenergic receptor, 515 Enzymes as reagents in peptide synthesis: Enzyme-labile protection for Catecholamine hormone receptor differences identified on 3T3 and carboxyl groups, 2739 simian virus-transformed 3T3 cells, 1091 Carboxypeptidase A (EC 3.4.12.2) Colchicine affects cyclic AMP levels in human leukocytes, 3404 Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: Nature 3':5'-Cyclic AMP: Independent induction of amino acid transport by of the azotyrosyl-248-zinc complex, 3273 epinephrine in primary cultures of adult rat liver cells, 234 Unified picture of mechanisms of catalysis by carboxypeptidase A, 1303 3':5'-Cyclic AMP: Independent induction of amino acid transport by Carboxypeptidase B (EC 3.4.12.3) epinephrine in primary cultures of adult rat liver cells (correction), Enzymes as reagents in peptide synthesis: Enzyme-labile protection for 2187 carboxyl groups, 2739 Determination of transmitter function by neuronal activity, 5767 Synthetic peptides with biological activities and specificity of human Explant cultures of catecholamine-containing neurons from rat brain: C3a anaphylatoxin, 1826 Biochemical, histofluorescence, and electron microscopic studies, 4471 Carcinogenesis, chemical Independent expression of adrenergic phenotype by neural crest cells in see also specific chemicals vitro, 2899 Bacteriophage system for screening and study of biologically active Induction of functional ,-adrenergic receptors in HeLa cells, 873 polycyclic aromatic hydrocarbons and related compounds, 1378 Norepinephrine induces glial-specific enzyme activity in cultured glioma Concentration of mutagens from urine by adsorption with nonpolar resin cells, 4501 XAD-2: Cigarette smokers have mutagenic urine, 3555 Reconstitution of catecholamine-sensitive adenylate cyclase activity: Differences in removal of acetylaminofluorene and pyrimidine dimers Interaction of solubilized components with receptor-replete from DNA of cultured mammalian cells, 1553 membranes, 3715 Dissociation of increases in levels of 3':5'-cyclic AMP and 3':'5-cyclic Stimulus-secretion coupling in chromaffin cells isolated from bovine adrenal medulla, 5036 Downloaded by guest on September 27, 2021 5792 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Cauchy integral Cell cycle of Saccharomyces cerevisiae in populations growing at Cauchy integrals on Lipschitz curves and related operators, 1324 different rates, 3850 Caulobacter crescentus Cell-cycle-related changes of 3':5'-cyclic GMP levels in Novikoff Mutational analysis of developmental control in Caulobacter crescentus, hepatoma cells, 1052 124 DNA synthesis induced in BALB/c 3T3 cells by serum components: C3 convertase Reevaluation of commitment process, 4481 Cleavage of C2 by Cls into antigenically distinct fragments C2a and C2b: Do myoblasts in vivo withdraw from the cell cycle? 2031 Binding of C2b to C4b, 2998 Histone and DNA synthesis: Noncoincidence in cleavage cycles of early Cell development, 5016 see also Differentiation, cell; Membrane, cell; specific cells Measurable G2 phase absent in two Chinese hamster cell lines, 1622 Cell adhesion Microviscosity modulation during cell cycle of neuroblastoma cells, 4458 Adhesive specificity of juvenile rat and chicken liver cells and Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during membranes, 1077 cell cycle of mouse mastocytoma cells, 1610 Cellular adhesion altered by nerve growth factor, 4055 Mutational analysis of developmental control in Caulobacter crescentus, Changes in surface properties of normal and transformed cells caused by 124 tunicamycin, inhibitor of protein glycosylation, 3433 Regulation of DNA synthesis: Age-dependent cooperation among G1l Isolation of bindin: Protein responsible for adhesion of sperm to sea cells upon fusion, 2869 urchin eggs, 2456 Role of surface modulating assemblies in growth control of normal and Mobility and distribution of a cell surface glycoprotein and its transformed fibroblasts, 666 interaction with other membrane components, 2909 Transient inhibition of initiation of S-phase associated with Rates of aggregation, loss of anchorage dependence, and tumorigenicity dimethylsulfoxide induction of murine erythroleukemia cells to of cultured cells, 258 erythroid differentiation, 248 Synapse turnover: Formation and termination of transient synapses, Cell, D 4977 Pancreatic immunoreactive somatostatin release, 2140 Cell, adrenocortical Cell death Angiotensin stimulation of bovine adrenocortical cell growth, 5569 Kinetics of cell death and disintegration in human lymphocyte cultures, Cell aggregation 2536 3':5'-Cyclic AMP-dependent 3':5'-cyclic GMP accumulation in Cell density Dictyostelium discoideum, 2348 Local starvation for epidermal growth factor cannot explain Specific factors influencing histotypic aggregation of chick embryo density-dependent inhibition of normal human glial cells, 1619 hepatocytes, 4486 Cell disintegration Cell, allogeneic Kinetics of cell death and disintegration in human lymphocyte cultures, Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator 2536 cells crossreact with chemically modified syngeneic cells, 1229 Cell, displaced ganglion Cell, aortic endothelial Specific projection of displaced retinal ganglion cells upon accessory Cultured aortic endothelial cells from pigs with von Willebrand disease: optic system in pigeon (Columbia livia), 1753 In vitro model for studying molecular defect(s) of the disease, 5702 Cell division Cell, astrocytoma Cellular division in Escherichia coli: Mutant of E. coli lacking a Glucocorticoids increase responsiveness of cells in culture to murein-lipoprotein, 1417 prostaglandin El, 4816 Epigenetic variation of cultured somatic cells: Gradual changes in Cell, B requirement for factors promoting cell division, 2928 Differential lateral mobility of IgM and IgG receptors in mouse B Cell, Ehrlich lymphocyte membranes, 4595 Amino-acid transport into Ehrlich cells: Unexpected additional mode of Direct demonstration of murine thymus-dependent cell surface energization, 1488 endogenous immunoglobulin, 2113 Cell, Ehrlich ascites tumor Endotoxin-induced serum factor controlling differentiation of 31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells, 87 bone-marrow-derived lymphocytes, 1200 Cell elongation Expression of Ia-like antigen molecules on human granulocytes during Cell wall extension in Nitella as influenced by acids and ions, 1565 early phases of differentiation, 4012 Cell, endothelial HLA-D associated alloantisera react with molecules similar to Ia Fibrinolytic activator and inhibitor synthesized by endothelial cells, 3903 antigens, 3533 Prostaglandin 12 (prostacyclin) synthesized by cultured human and Immunological defect and its correction in osteopetrotic mutant rat, 339 bovine endothelial cells, 3922 Proliferative and plaque-forming cell responses inhibited by human Cell, epidermal bone-marrow-derived lymphocytes from peripheral blood by antisera Dissociation of tumor promoter-stimulated ornithine decarboxylase to p23,30 antigen, 711 activity and DNA synthesis in mouse epidermis in vivo and in vitro by Cell, baby hamster kidney fluocinolone acetonide, a tumor-promotion inhibitor, 3908 Isolation and preliminary characterization of 10-nm filaments from baby Cell, epithelial hamster kidney (BHK-21) cells, 2422 Antitubulins affect redistribution of crosslinked receptors on surface of Protease effects on specific growth properties of normal and transformed fibroblasts and epithelial cells, 2865 baby hamster kidney cells, 2874 Density-dependent regulation of growth of BSC-1 cells in cell culture: Cell, basophilic leukemia Control of growth by serum factors, 5046 Precursor role of arachidonic acid in release of slow reacting substance Heteroploid conversion of human skin cells by methylcholanthrene, 2451 from rat basophilic leukemia cells, 4577 Cell, epithelioid Cell, BSC-1 Filaments 7-10 nm thick visualized in cultured cells of an epithelioid line Density-dependent regulation of growth of BSC-1 cells in cell culture: (Pt K2) by immunofluorescence microscopy, 2490 Control of growth by serum factors, 5046 Cell, erythroid Cell, cartilage see also Cell, nucleated erythroid Cellular transformation and differentiation: Effect of Rous sarcoma virus Hemoglobin F synthesis in vitro: Control at level of primitive erythroid transformation on sulfated proteoglycan synthesis by chicken stem cells, 2923 chondrocytes, 4173 Plasma membrane proteins: Changes in composition during Cell, Chinese hamster differentiation of embryonic chick erythroid cell, 1062 Measurable G2 phase absent in two Chinese hamster cell lines, 1622 Pure and mixed eyrthroid colony formation in vitro stimulated by spleen Cell, Chinese hamster ovary conditioned medium with no detectable erythropoietin, 3879 Asparaginyl-tRNA in regulation of asparagine synthetase in a Relative stability of (a- and I-globin messenger RNAs in homozygous fl+ mammalian cell line, 2367 thalassemia, 3960 Cholesterol-requiring mutant of Chinese hamster ovary cells: Isolation Cell, erythroid precursor and partial characterization, 832 Characterization of an erythroid precursor cell of high proliferative Codominant markers transferred by isolated metaphase chromosomes in capacity in normal human peripheral blood, 1105 Chinese hamster ovary cells, 3480 Cell, erythroleukemia Codominant markers transferred by isolated metaphase chromosomes in Chromatin protein appears during erythroid differentiation of Friend Chinese hamster ovary cells (correction), 5776 virus-transformed cells, 653 Selective loss of wheat germ agglutinin binding to agglutinin-resistant Chromatin protein appears during erythroid differentiation of Friend mutants of Chinese hamster ovary cells, 5056 virus-transformed cells (correction), 3104 Cell, chromaffin Differential effects of chemical inducers on expression of /3 globin genes Stimulus-secretion coupling in chromaffin cells isolated from bovine in murine erythroleukemia cells, 1.100 adrenal medulla, 5036 Extinction of hemoglobi inducibilityn in Friend erythroleukemia cells by Cell cloning fusion with cytoplasm of enucleated mouse neuroblastoma or Pure and mixed eyrthroid colony formation in vitro stimulated by spleen fibroblast cells, 1642 conditioned medium with no detectable erythropoietin, 3879 Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: Cell communication Increased transcription during erythroid differentiation, 2475 Cell-to-cell stimulation of movement in nonmotile mutants of Inhibition of cytokinesis in Friend leukemia cells by membrane mobility Myxococcus, 2938 agents, 2884 Contact-mediated communication compared in normal and transformed Inhibition of transcription and translation of globin messenger RNA in human cells in culture, 4476 dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated Cell cycle with interferon, 2036 Adenylate cyclase from synchronized neuroblastoma cells: Low-molecular-weight peptide inhibits RNA synthesis in human Responsiveness to prostaglandin E1, adenosine, and dopamine during leukemic and phytohemagglutinin-stimulated leukocytes and globin cell cycle, 1575 mRNA transcription in differentiating Friend cells, 3869 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5793

Putative 15S precursor to 3-globin mRNA but not to a-globin mRNA in Isolation of virus-free Herpesvirus saimiri antigen-positive plasma Friend cells, 3184 membrane vesicles, 2546 Spectrin induced in erythroleukemic cells transformed by Friend virus, Cell, killer 3898 Killer cells reactive to altered-self antigens can also be alloreactive, 2094 Transient inhibition of initiation of S-phase associated with Cell, L dimethylsulfoxide induction of murine erythroleukemia cells to Enucleation and reconstruction of interferon-producing cells, 3391 erythroid differentiation, 248 Nerve growth factor secreted by L cells: Molecular properties, 1492 Tumor promoters inhibit spontaneous differentiation of Friend Overexpression of an unstably inherited gene in cultured mouse cells, erythroleukemia cells in culture, 2894 3956 Tumor promoters inhibit spontaneous and induced differentiation of Reconstitution of catecholamine-sensitive adenylate cyclase activity: murine erythroleukemia cells in culture, 3451 Interaction of solubilized components with receptor-replete Cell, fetal erythroid membranes, 3715 Hemoglobin switching in sheep and goats: Induction of hemoglobin C Transmembrane bridging proteins identified in plasma membrane of synthesis in cultures of sheep fetal erythroid cells, 5078 cultured mouse L cells, 5341 Cell, Friend Cell, lens fiber see Cell, erythroleukemia DNA degradation in terminally differentiating lens fiber cells from chick Cell fusion embryos, 5579 Antibodies against influenza virus produced by somatic cell hybrids Cell, leukemic between mouse myeloma and primed spleen cells, 2985 Regulation of cholesterol biosynthesis by normal and leukemic (L2C) Cell fusion induced by herpes simplex virus is promoted and suppressed guinea pig lymphocytes, 956 by different viral glycoproteins, 3913 Cell, Leydig Cells reconstituted from cell fragments of two different species multiply Intermediate role of adenosine 3':5'-cyclic monophosphate and protein and form colonies, 606 kinase during gonadotropin-induced steroidogenesis in testicular Regulation of DNA synthesis: Age-dependent cooperation among G1 interstitial cells, 3419 cells upon fusion, 2869 Cell, liver Cell, glial Acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in Local starvation for epidermal growth factor cannot explain liver cell, 1497 density-dependent inhibition of normal human glial cells, 1619 Adhesive specificity of juvenile rat and chicken liver cells and Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit membranes, 1077 synthesis of brain-specific protein in rat glial cells, 3855 3':5'-Cyclic AMP: Independent induction of amino acid transport by Cell, glioma epinephrine in primary cultures of adult rat liver cells, 234 Norepinephrine induces glial-specific enzyme activity in cultured glioma 3':5'-Cyclic AMP: Independent induction of amino acid transport by cells, 4501 epinephrine in primary cultures of adult rat liver cells (correction), Cell growth 2187 Amino-terminal sequences of two polypeptides from human serum with Cell locomotion nonsuppressible insulin-like and cell-growth-promoting activities: Phalloidin-induced actin polymerization in cytoplasm of cultured cells Structural homology with insulin B chain (correction), 1301 interferes with cell locomotion and growth, 5613 Angiotensin stimulation of bovine adrenocortical cell growth, 5569 Cell, lymph node Complexes of inorganic pyrophosphate, orthophosphate, and calcium as Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: stimulants of 3T3 cell multiplication, 5026 Evidence for T cell interactions, 5667 Control of growth by picolinic acid: Differential response of normal and Cell, lymphoblastoid transformed cells, 2889 HLA-D associated alloantisera react with molecules similar to Ia Density-dependent regulation of growth of BSC-1 cells in cell culture: antigens, 3533 Control of growth by serum factors, 5046 Host-determined differences in expression of surface marker Division of BALB/c mouse 3T3 and simian virus 40-transformed 3T3 characteristics on human and simian lymphoblastoid cell lines cells in cellular aggregates, 3874 transformed by Epstein-Barr virus, 749 Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface Synthesis of human interferon by Xenopus laevis oocytes: Two membranes, 2251 structural genes for interferons in human cells, 3287 Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface Cell, lymphoid membranes (correction), 4706 Antigenic distinctions of glycoproteins in plasma and mitochondrial Loss of growth control and differentiation in fu-1 variant of L- line of rat membranes of lymphoid cells neoplastically transformed by simian myoblasts, 3888 virus 40, 643 Phalloidin-induced actin polymerization in cytoplasm of cultured cells Cell, mammalian interferes with cell locomotion and growth, 5613 Differences in removal of acetylaminofluorene and pyrimidine dimers Protease effects on specific growth properties of normal and transformed from DNA of cultured mammalian cells, 1553 baby hamster kidney cells, 2874 Cell, mammary epithelial Temporal sequence of hormonal interactions during prereplicative phase Hormonal effects on intracellular and secreted casein in cultures of of quiescent cultured 3T3 fibroblasts, 3845 mouse mammary epithelial cells on floating collagen membranes, 4466 Cell, guard Surface differentiation antigens of human mammary epthelial cells Organic acid and potassium accumulation in guard cells during stomatal carried on human milk fat globule, 582 opening, 4434 Cell, marrow Cell, hair Thymic activity in severe combined immunodeficiency diseases, 1250 Sensitivity, polarity, and conductance change in response of vertebrate Cell, mast hair cells to controlled mechanical stimuli, 2407 Dimeric immunoglobulin E serves as unit signal for mast cell Cell, hamster degranulation, 2993 Virion polypeptides identified in hamster cells transformed by herpes Cell, mastocytoma simplex virus type 1, 372 Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during Cell, HeLa cell cycle of mouse mastocytoma cells, 1610 Evidence from UV transcription mapping in HeLa cells that Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during heterogeneous nuclear RNA is the messenger RNA precursor, 4520 cell cycle of mouse mastocytoma cells (correction), 3621 HeLa cell poly(A)- mRNA codes for subset of poly(A)+ mRNA-directed Cell, melanoma proteins with actin as major product, 4801 Nerve growth factor receptors on human melanoma cells in culture, 565 Heterogeneous nuclear RNA secondary structure: Oligo(U) sequences Number of receptors for /-melanocyte stimulating hormone in Cloudman base-paired with poly(A) and their possible role as binding sites for melanoma cells is increased by dibutyryl adenosine 3':5'-cyclic heterogeneous nuclear RNA-specific proteins, 1426 monophosphate or cholera toxin, 601 Induction of functional /-adrenergic receptors in HeLa cells, 873 Cell, monkey kidney Nucleoplasmic RNA: Definition of subclasses, 5011 Genetic analysis of host range mutant viruses suggests uncoating defect Polypeptide synthesis initiated with various NH2-blocked in simian virus 40-resistant monkey cells, 3503 aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5909 Cell morphology Protein scaffold isolated from mitotic HeLa cell chromosomes, 4937 Cyclic AMP, microtubule-microfilament system, and cancer, 4491 Protein structure of probable membrane derivation associated with Cell motility HeLa cell mitochondrial DNA near its origin of replication, 1348 Direction of active sliding of microtubules in Tetrahymena cilia, 2045 5'-Terminal capping of RNA by guanylyltransferase from HeLa cell Flagellar mutants of Chlamydomonas: Studies of radial spoke-defective nuclei, 3758 strains by dikaryon and revertant analysis, 3456 Transcriptionally active chromatin isolated from mammalian nucleoli, 69 Intracellular distributions of mechanochemical proteins in cultured Transmembrane interactions and mechanism of capping of surface fibroblasts, 3883 receptors by their specific ligands, 5031 Cell, muscle Tryptic peptide analysis of normal and mutant forms of hypoxanthine Biosynthesis of type I and III collagens by cultured smooth muscle cells phosphoribosyltransferase from HeLa cells, 926 from human aorta, 671 Cell, hepatoma Bovine brain filament antibody localized on intermediate (100 A) High aerobic glycolysis of rat hepatoma cells in culture: Role of filaments in guinea pig vascular endothelial cells and chick cardiac mitochondrial hexokinase, 3735 muscle cells, 662 Cell, hybrid Major structural and regulatory proteins of chick muscle cells: Invariance see Hybrid cell and heterogeneity revealed by two-dimensional gel electrophoresis, Cell, kidney 1450 Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby Reinnervation of original synaptic sites on muscle fiber basement hamster kidney 21/C13 cells and in secondary mouse embryo membrane after disruption of muscle cells, 3073 fibroblasts C57BL/6J, 979 Downloaded by guest on September 27, 2021 5794 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Synthesis and secretion of high molecular weight form of nerve growth Cell, suppressor factor by skeletal muscle cells in culture, 4496 Key antigenic determinants in regulation of immune respone, 3984 Cell, myeloid leukemic Potentiation of primary in vivuoantibody response by alloantisera against Chromosome mapping of genes that control differentiation and gene products of I region of H-2 complex, 3975 malignancy in myeloid leukemic cells, 253 Suppression of immunoglobulin synthesis and secretion by peripheral Genetic dissection of control of normal differentiation in myeloid blood lymphocytes from normal donors, 2099 leukemic cells, 5554 Cell surface Cell, myeloma see also Antigen, cell surface; Membrane, cell surface; Protein, Antigen-binding mutants of mouse myeloma cells, 5687 cell-surface; Receptor, cell surface Variable and constant parts of immunoglobulin light chain gene of a Anionic glycopeptides and glycosaminoglycans synthesized by embryonic mouse myeloma cell are 1250 nontranslated bases apart, 5652 neural tube and neural crest, 1057 Cell, nerve Anionic glycopeptides and glycosaminoglycans synthesized by embryonic Cholinergic metabolism and synapse formation by a rat nerve cell line, neural tube and neural crest (correction), 4076 2579 Cell-surface carbohydrate How to label nerve cells so that they can interconnect in an ordered Cell surface carbohydrates and proteins in cell behavior: Biochemical fashion, 5176 reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 Cell, neural crest Selective loss of wheat germ agglutinin binding to agglutinin-resistant Independent expression of adrenergic phenotype by neural crest cells in mutants of Chinese hamster ovary cells, 5056 vitro, 2899 Cell-surface macromolecule Independent expression of adrenergic phenotype by neural crest cells in Third complement protein and cell surface macromolecules: Interaction, vitro (correction), 4706 2701 Cell,. neuroblastoma Cell-surface marker Adenylate cyclase from synchronized neuroblastoma cells: Host-determined differences in expression of surface marker Responsiveness to prostaglandin E1, adenosine, and dopamine during characteristics on human and simian lymphoblastoid cell lines cell cycle, 1575 transformed by Epstein-Barr virus, 749 Embryonic chicken brain and mouse neuroblastoma cells NIE-115 and Cell synchronization N-18 contain an inhibitor of acid deoxyribonuclease, 842 Adenylate cyclase from synchronized neuroblastoma cells: Enzyme regulation in neuroblastoma cells in a salts/glucose medium: Responsiveness to prostaglandin El, adenosine, and dopamine during Induction of ornithine decarboxylase by asparagine and glutamine, cell cycle, 1575 3791 Cell-cycle-related changes of 3':5'-cyclic GMP levels in Novikoff Extinction of hemoglobin inducibility in Friend erythroleukemia cells by hepatoma cells, 1052 fusion with cytoplasm of enucleated mouse neuroblastoma or Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during fibroblast cells, 1642 cell cycle of mouse mastocytoma cells, 1610 Microviscosity modulation during cell cycle of neuroblastoma cells, 4458 Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during Morphological differentiation of neuroblastoma cells in medium cell cycle of mouse mastocytoma cells (correction), 3621 supplemented with delipidated serum, 3893 Cell, syngeneic Cell, Novikoff hepatoma Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator Cell-cycle-related changes of 3':5'-cyclic GMP levels in Novikoff cells crossreact with chemically modified syngeneic cells, 1229 hepatoma cells, 1052 Cell, T Cell, nucleated erythroid Activation of cytotoxic T cells by nonstimulating tumor cells and spleen Putative precursor of globin messenger RNA purified from mouse cell factor(s), 4610 nucleated erythroid cells, 178 Antigenic complex recognized by T lymphocytes: Specific sensitization Cellophane by antigens associated with allogeneic macrophages, 2104 Phage T4-modified RNA polymerase transcribes T4 late genes in vitro, Binding to idiotypic determinants of large proportions of thymus-derived 5305 lymphocytes in idiotypically suppressed mice, 2084 Cell, pancreatic acinar Combined use of fetal liver and thymus for immunological reconstitution Transport of a-amylase across basolateral membrane of pancreatic in patients with variants of severe combined immunodeficiency, 3002 acinar cell, 4068 Complexes of inorganic pyrophosphate, orthophosphate, and calcium as Cell, pancreatic beta stimulants of 3T3 cell multiplication, 5026 Streptozotocin-induced insulitis and diabetes, 2485 Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator Cell, parathyroid cells crossreact with chemically modified syngeneic cells, 1229 Dopaminergic stimulation of cyclic AMP accumulation and parathyroid Direct demonstration of murine thymus-dependent cell surface hormone release from dispersed bovine parathyroid cells, 4210 endogenous immunoglobulin, 2113 Cell, pheochromocytoma Division of BALB/c mouse 3T3 and simian virus 40-transformed 3T3 Specific neural and adrenal medullary antigens detected by antisera to cells in cellular aggregates, 3874 clonal PC12 pheochromocytoma cells, 5021 Heterogeneity of cytotoxic response of thymus-derived lymphocytes after Cell, pituitary immunization with influenza viruses, 1209 Common precursor to corticotropins and endorphins, 3014 Immunoglobulin-dependent antigen-specific helper 'F cell, 4582 Pregrowth hormone messenger RNA: Glucocorticoid induction and Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface identification in rat pituitary cells, 2357 membranes, 2251 Cell proliferation Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface Histone gene transcription activated by nonhistone chromosomal membranes (correction), 4706 proteins in WI-38 human diploid fibroblasts, 173 Key antigenic determinants in regulation of immune respone, 3984 Cell, Purkinje Killer cells reactive to altered-self antigens can also be alloreactive, 2094 Mechanisms by which diazepam, muscimol, and other drugs change the Lymphocyte mitogenesis induced by mammalian liver protein that content of cGMP in cerebellar cortex, 3592 specifically binds desialylated glycoproteins, 676 Cell recognition Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: Adhesive specificity of juvenile rat and chicken liver cells and Evidence for T cell interactions, 5667 membranes, 1077 Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator Cell, reconstituted cells exhibit specificity for H-2 complex alloantigens, 4572 Cells reconstituted from cell fragments of two different species multiply Physiological regulation of antigen binding to T cells: Role of soluble and form colonies, 606 macrophage factor and of interferon, 5662 Cell replication Potentiation of primary in vivo antibody response by alloantisera against In vivuoanalysis of cellular replication, 2041 gene products of I region of H-2 complex, 3975 Cell, retina Secretion of mediators following T lymphocyte-macrophage interaction Synapse turnover: Formation and termination of transient synapses, is regulated by major histocompatibility complex, 3542 4977 Sequential stages of human T lymphocyte differentiation, 341.4 Cell, retinal ganglion Specific changes in collagen phenotype of BALB 3T3 cells: Result of Nonlinear analysis of cat retinal ganglion cells in the frequency domain, transformation by sarcoma viruses or a chemical carcinogen, 2933 3068 Specificity studies on cytotoxic thymus-derived lymphocytes reactive Cell, secretory with influenza virus-infected cells: Dual recognition of H-2 and viral Luminal membrane retrieved after exocytosis reaches most Golgi hemagglutinin antigens, 3006 cisternae in secretory cells, 5073 Sugar uptake and thymidine incorporation in mouse 3T3 cells stimulated Cell, spleen by calcium phosphate and other extracellular particles, 5593 Pure and mixed eyrthroid colony formation in vitro stimulated by spleen Suppressor cell regulation of immune response to tumors: Abrogation by conditioned medium with no detectable erythropoietin, 3879 adult thymectomy, 2989 Unprimed spleen cell populations'recognize macrophage-bound antigen Temporal sequence of hormonal interactions during prereplicative phase with opposite net electric charge, 1693 of quiescent cultured 3T3 fibroblasts, 3845 Cell structure Thymosin a1: Isolation and sequence analysis of immunologically active In vitro assembly of pure tubulin into microtubules in absence of thymic polypeptide, 725 microtubule-associated proteins and glycerol, 1860 Transmembrane interactions and mechanism of capping of surface Cell, substance P receptors by their specific ligands, 5031 Immunocytochemical identification of substance P cells and their Variants of 3T3 cells lacking mitogenic response to epidermal growth processes in rat sensory ganglia and their terminals in spinal cord: factor, 3918 Light micr(oscopic studies, 3597 Cell, tendon Ultrastructural identification of substance P cells and their processes in Dependence of differentiated state on cellular environment: Modulation rat sensory ganglia and their terminals in spinal cord by of collagen synthesis in tendon cells, 4453 immunocytochemistry, 4050 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5795

Cell, teratocarcinoma Chlorophyll lasers: Stimulated light emission by chlorophylls and Rejection by syngeneic mice of cell variants obtained by mutagenesis of Mg-free chlorophyll derivatives, 5 teratocarcinoma cell line, 272 Circular dichroism of adenosine dinucleotides, 1785 Cell, thyroid 13C nuclear magnetic resonance study of five- and six-coordinated carbon Effects of thyrotropin on thyroid cell membrane: Hyperpolarization in nonclassical organometallic compounds: Dimeric trialkyl-, induced by hormone-receptor interaction, 2352 tricyclopropyl-, and triarylaluminums and some nido and closo Cell, tobacco carboranes, 5217 Derepression of ATP sulfurylase by sulfate analogs molybdlate and Conformational basis for activation of adenylate cyclase by adenosine, selenate in cultured tobacco cells, 619 2194 Cell, tumor Covalence of atoms in the heavier transition metals, 2614 Antigenic crossreactivity to RD114 p30 protein, expressed in a human Detailed electronic description of triple bonds between transition metal fibrosarcoma cell line, 744 atoms and verification by photoelectron spectroscopy, 3109 Development of tumor cell resistance to syngeneic cell-mediated Dioxygen bonding in hemoglobin: Molecular description, 1315 cytotoxicity during growth of ascitic mastocytoma P815Y, 329 Electron affinity of methyl radical: Structures of CH3 and CH3-, 410 Establishment and characterization of a strain of human adrenal tumor Electrophilic mercuration and thallation of benzene and substituted cells that secrete estrogen, 1067 benzenes in trifluoroacetic acid solution, 4121 Opiate peptides synthesized by a clonal pituitary tumor cell line, 2259 Energy-structure correlation in metalloporphyrins and control of oxygen Selection of reconstituted cells from karyoplasts fused to binding by hemoglobin, 1789 chloramphenicol-resistant cytoplasts, 2461 Enkephalin: Conformational analysis by empirical energy calculations, Cellular immunity 414 Unprimed spleen cell populations recognize macrophage-bound antigen Enzyme-enzyme interactions affect steady-state enzyme kinetics, 4111 with opposite net electric charge, 1693 Enzyme-substrate complexes of lysozyme: Structures, 2629 Cell, vascular endothelial Excited state lifetimes in cytochromes measured from Raman scattering Bovine brain filament antibody localized on intermediate (100 A) data: Iron-porphyrin interactions, 2607 filaments in guinea pig vascular endothelial cells and chick cardiac Hydrophobicity, hydrophilicity, and radial and orientational muscle cells, 662 distributions of residues in native proteins, 5248 Cell wall Intramolecular general base-catalyzed ester hydrolyses by imidazolyl Cell wall extension in Nitella as influenced by acids and ions, 1565 group, 23 Dynamic structure of whole cells probed by nuclear Overhauser Intramolecular general base-catalyzed ester hydrolyses by imidazolyl enhanced nitrogen-15 nuclear magnetic resonance spectroscopy, 1988 group (correction), 3621 Central nervous system Kinetic polarization deficiency in electrolyte solutions, 401 Endogenous nonpeptide morphine-like compound: Binding to opiate Kinetics of hemoglobin-carbon monoxide reactions measured with a receptors, 4927 superconducting magnetometer: Method for fast reactions in solution, Molecular basis of reovirus virulence: Role of S1 gene, 5744 2620 Neurotensin: Immunohistochemical localization in rat central nervous Light-regulated permeability of rhodopsin:egg phosphatidylcholine system, 4059 recombinant membranes, 5222 Neurotensin: Immunohistochemical localization in rat central nervous Local interactions in bends of proteins, 4126 system (correction), 5777 Magnetic properties of oxyhemoglobin, 398 Opioid peptide enkephalin: Immunohistochemical mapping in rat central Mathematical description of molecular structure: Molecular topology, nervous system, 2167 2616 Synaptic acetylcholine receptor sites identified in retina with Mechanism of oxidation of tryptophan to formylkynurenine-25 years peroxidase-labeled (v-bungarotoxin, 3268 later, 4730 Centrifugation, differential Methylcyclopentanoid terpenes from larval defensive secretion of a Sedimentation properties of scrapie agent, 4656 chrysomelid beetle (Plagiodera versicolora), 2189 Cephalosporin Model for "charge-relay": Acceleration by carboxylate anion in Transition state structures of dipeptide related to mode of action of intramolecular general base-catalyzed ester hydrolysis by imidazolyl j3-lactam antibiotics, 5239 group, 2634 Cerebellum Netropsin-poly(dA-dT) complex in solution: Structure and dynamics of Calcium modulation in brain extracellular microenvironment antibiotic-free base pair regions and those centered on bound demonstrated with ion-selective micropipette, 1287 netropsin, 5207 Mechanisms by which diazepam, muscimol, and other drugs change the Nitrogen-15 nuclear magnetic resonance of aliphatic tripeptides, 1308 content of cGMP in cerebellar cortex, 3592 n-Type Si-based photoelectrochemical cell: Liquid junction photocell Cerebral dominance using a nonaqueous ferricenium/ferrocene electrolyte, 4116 Active touch exploration of extrapersonal space elicits specific Nucleic acid components: Ultraviolet resonant Raman spectroscopy, 2639 electrogenesis in right cerebral hemisphere of intact right-handed man, Oxyhemoglobin: Magnetic properties and structure, 2612 4037 Picosecond dynamics of iron proteins, 4139 Ceruloplasmin Pressure affects visible spectra of complexes of myoglobin, hemoglobin, see Ferroxidase cytochrome c, and horse radish peroxidase, 1 Chelator Primary photochemical event in vision: Proton translocation, 3119 Binding of Zn2+ to rat liver fructose-l,6-bisphosphatase and its effect on Protein folding: Incorporation of a one-dimensional short-range (Ising) catalytic properties, 2742 model into a three-dimensional model, 1320 Control of growth by picolinic acid: Differential response of normal and Quantum statistical theory of optical phenomena, 3105 transformed cells, 2889 Radiationless relaxation in "large" molecules: Preparation of true Chemiluminescence molecular eigenstates and Born-Oppenheimer states by a coherent Chemiluminescent reactions and electrophilic oxygen donating ability of light source, 1310 4a-hydroperoxyflavins: Preparation of N5-alkyl-1,5-dihydroflavins, 405 Rates of dissolution of Fe4S4 clusters of Chromatium vinosum Chemiosmosis high-potential iron protein and ferredoxin depend on cluster oxidation Control of serotonin secretion from human platelets by hydroxyl ion state, 5231 transport and osmotic lysis, 5295 Relaxation phenomena: A general treatment, 3623 Chemiosmotic hypothesis Resonance coherent anti-Stokes Raman scattering spectra of fluorescent H+/ATP ratio during ATP hydrolysis by mitochondria: Modification of biological chromophores: Vibrational evidence for hydrogen bonding of chemiosmotic theory, 1955 flavin to glucose oxidase and for rapid solvent exchange, 4146 High-resolution 31p nuclear magnetic resonance studies of metabolism in Sequence specificity of mutagen-nucleic acid complexes in solution: aerobic Escherichia coli cells, 888 Intercalation and mutagen-base pair overlap geometries for proflavine Sodium-stimulated glutamate uptake in membrane vesicles of binding of dC-dC-dG-dG and dG-dG-dC-dC self-complementary Escherichia coli: Role of ion gradients, 3167 duplexes, 2624 Chemisorption Significant structure theory applied to phase separation, 10 Surface, catalytic, and magnetic properties of small iron particles: Effect Significant structure theory applied to liquid helium-3, 4739 of chemisorption of hydrogen on magnetic anisotropy, 806 Single partition function for three phases, 2598 Chemistry Spatial configuration of ordered polynucleotide chains: A novel double see also Histochemistry; Immunocytochemistry; Immunohistochemistry; helix, 1775 Stereochemistry Stable conformations of aliphatic disulfides: Influence of 1,4 interactions Adenylate kinase: 31p nuclear magnetic resonance kinetic measurements, involving sulfur atoms, 13 3627 Structure of cytochrome c5s5 of Chlorobium thiosulfatophilum: Primitive Biochemical catalysis involving coenzyme B-12: Mechanistic low-potential cytochrome c, 5244 interpretation of vicinal interchange rearrangements, 811 Structure of proteins: Packing of o-helices and pleated sheets, 4130 Biogenic amine-ionophore interactions: Structure and dynamics of Structure of transition-metal cluster compounds: Use of additional lasalocid (X537A) complexes with phenethylamines and orbital resulting from f, g character of spd bond orbitals, 5235 catecholamines in nonpolar solution, 4734 Surface, catalytic, and magnetic properties of small iron particles: Effect Blue copper proteins: Synthesis, spectra, and structures of Cu'N3(SR) of chemisorption of hydrogen on magnetic anisotropy, 806 and Cu"N3(SR) active site analogues, 3114 Synthesis and characterization of "face-to-face" porphyrins, 18 Bonding of FeO2 in hemoglobin and related dioxygen complexes, 1780 Synthesis of 13,14-dehydroprostacyclin methyl ester: Inhibitor of platelet Characterization and synthesis of volatile compounds for defensive aggregation, 2199 secretions of "daddy longlegs" (Arachnida: Opiliones: Leiobunum Tertiary structural change in hemoglobin: Mechanism, 801 spp.), 419 Theoretical study of effect of enzyme-enzyme interactions on Chemiluminescent reactions and electrophilic oxygen donating ability of steady-state enzyme kinetics, 3632 4a-hydroperoxyflavips: Preparation of N5-alkyl-1,5-dihydroflavins, 405 Thermodynamic aspects of linkage between binding o(f chloride and oxygen to human hemoglobin, 4135 Downloaded by guest on September 27, 2021 5796 SubjectIndex Proc. 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Time-resolved resonance Raman spectroscopy of bacteriorhodopsin on transmission in Chlamydomonas reinhardtii by 5-fluorodeoxyuridine, the millisecond timescale, 5212 4552 Transition state structures of dipeptide related to mode of action of Quantum efficiency of photosynthetic energy conversion, 3377 (-lactam antibiotics, 5239 Ribulose-1,5-bisphosphate carboxylase-oxygenase structure: Form III Unified picture of mechanisms of catalysis by carboxypeptidase A, 1303 crystals, 1037 Use of solvent cavity area and number of packed solvent molecules Selective scattering spectra as an approach to internal structure of granal around a solute in regard to hydrocarbon solubilities and hydrophobic and agranal chloroplasts, 1455 interactions, 4144 Cholecystokinin "Virial" expansion of enzyme flux and use of quasi-chemical Cholecystokinin and its COOH-terminal octapeptide in pig brain, 3035 approximation for two-state enzymes with enzyme-enzyme Immunohistochemical localization in rabbit brain of a peptide interactions, 5227 resembling COOH-terminal octapeptide of cholecystokinin, 3033 Water molecules: Arrangement in cavities and channels of lattice of Choleragen [Phe4Val6]antamanide dodecahydrate, 2602 Choleragen activation of solubilized adenylate cyclase: GTP and protein X-ray absorption studies of halide binding to carbonic anhydrase, 1794 activator required for demonstration of enzymatic activity, 4396 Chemoaffinity hypothesis Enzyme regulation in neuroblastoma cells in a salts/glucose medium: Localization of motor neuron pools supplying identified muscles in Induction of ornithine decarboxylase by asparagine and glutamine, normal and supernumerary legs of chick embryo, 3582 3791 Chemotaxis Gangliosides and substrate analogues affect hydrolysis of nicotinamide Bacterial flagella rotating in bundles: Study in helical geometry, 221 adenine dinucleotide by choleragen, 74 Chemotaxis in Escherichia coli: Methylation of che gene products, 3317 Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of 3':5'-Cyclic AMP-dependent 3':5'-cyclic GMP accumulation in GTP hydrolysis at regulatory site, 3307 Dictyostelium discoideum, 2348 Number of receptors for l-melanocyte stimulating hormone in Cloudman Local control of neurite development by nerve growth factor, 4516 melanoma cells is increased by dibutyryl adenosine 3':5'-cyclic Protein methyltransferase identified as cheR gene product in bacterial monophosphate or cholera toxin, 601 sensing system, 533 Transfer of ADP-ribose from NAD to choleragen: A subunit acts as Sensory electrophysiology of bacteria: Relationship of membrane catalyst and acceptor protein, 5440 potential to motility and chemotaxis in Bacillus subtilis, 4752 Ultrastructural localization of cell membrane GM ganglioside by cholera Sensory transduction in Escherichia coli: Requirement for methionine in toxin, 3782 sensory adaptation, 183 Cholera toxin Sensory transduction in Escherichia coli: Two complementary pathways see Choleragen of information processing that involve methylated proteins, 3312 Cholestanetriol 26-hydroxylase Sensory transduction in Escherichia coli: Role of protein methylation Hepatic mitochondrial cytochrome P-450: Isolation and functional reaction in sensory adaptation, 4964 characterization, 5477 Specific receptor sites for chemotactic peptides on human Cholesterol polymorphonuclear leukocytes, 1204 Cholesterol and lanosterol: Differential effects on artificial membranes, Use of a distant reporter group as evidence for conformational change in 4924 a sensory receptor, 1932 Cholesterol-requiring mutant of Chinese hamster ovary cells: Isolation Chemotherapy and partial characterization, 832 Antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine: Selectivity of Cholesterol synthesis in rat adrenal gland regulated through coordinate action, 5716 control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and Deoxycytidine deaminase activity induced in mammalian cell lines by reductase activities, 1421 infection with herpes simplex virus type 1, 1734 Daily cholesterol synthesis rates in man measured by assay of fractional Solid tumor models for assessment of different treatment modalities: conversion of mevalonic acid to cholesterol, 3043 Therapeutic strategy for sequential chemotherapy with radiotherapy, Hepatic mitochondrial cytochrome P-450: Isolation and functional 1983 characterization, 5477 Chern class 25-Hydroxycholesterol and cholesterol bind to different cytoplasmic Calabi's conjecture and some new results in algebraic geometry, 1798 proteins, 2500 Chitin Regenerated endothelium affects lipid accumulation in arterial wall, 1724 Developmental defects associated with glucosamine auxotropy in Regulation of cholesterol biosynthesis by normal and leukemic (L2C) Saccharomyces cerevisiae, 4351 guinea pig lymphocytes, 956 Chlamydomonas reinhardi Serum sex hormones and glucose, insulin, and lipid abnormalities in men Identification and cloning of chloroplast gene coding for large subunit of with myocardial infarction, 1729 ribulose-1,5-bisphosphate carboxylase from Chlamydomonas Transmembrane movement of cholesterol in human erythrocytes, 1538 reinhardi, 3193 Cholesterol ester Chlamydomonas reinhardtii Structure of human plasma low-density lipoproteins: Molecular Flagellar mutants of Chlamydomonas: Studies of radial spoke-defective organization of central core, 1042 strains by dikaryon and revertant analysis, 3456 Cholesterol esterase Flagellar proteins from wild-type and paralyzed mutants of Activation of hormone-sensitive lipase and phosphorylase kinase by Chlamydomonas reinhardtii: Two-dimensional analysis, 1600 purified cyclic GMP-dependent protein kinase, 4843 In vitro synthesis and processing of a putative precursor for the small Cholesterol, 25-hydroxy- subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas 25-Hydroxycholesterol and cholesterol bind to different cytoplasmic reinhardtii, 1082 proteins, 2500 Perturbation of chloroplast DNA amounts and chloroplast gene Choline transmission in Chlamydomonas reinhardtii by 5-fluorodeoxyuridine, Trans-synaptic induction of adrenornedullary tyrosine hydroxylase 4552 activity by choline: Choline administration can increase cholinergic Selective enrichment of photosynthetic electron transport mutants, 610 transmission, 798 Site-specific single-strand endonuclease from the eukaryote Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Chlamydomonas, 2687 activity by choline: Choline administration can increase cholinergic Chloramphenicol transmission (correction), 2594 DNA-dependent RNA polymerase involved in a recA-independent Choline acetyltransferase (EC 2.3.1.6) pathway of genetic recombination in Escherichia coli, 3932 Cholinergic metabolism and synapse formation by a rat nerve cell line, Selection of reconstituted cells from karyoplasts fused to 2579 chloramphenicol-resistant cytoplasts, 2461 Cholinergic compound Selective amplification of genes on the R plasmid, NR1, in Proteus Cholinergic ligands and local anesthetics interact with plasma membrane mirabilis: Example of induction of selective gene amplification, 2518 fragments from lobster axon, 2278 Chlorobium thiosulfatophilum Opposing effects of dopaminergic to cholinergic compounds on cerebral Structure of cytochrome c555 of Chlorobium thiosulfatophilum: Primitive dopamine-activated adenylate cyclase, 769 low-potential cytochrome c, 5244 Cholinergic ligand Chlorophyll Phosphorylation of membrane proteins at cholinergic synapse, 263 Chlorophyll b identified in extracts of prokaryotic algae by fluorescence Chondrocyte spectroscopy, 575 Cellular transformation and differentiation: Effect of Rous sarcoma virus Chlorophyll lasers: Stimulated light emission by chlorophylls and transformation on sulfated proteoglycan synthesis by chicken Mg-free chlorophyll derivatives, 5 chondrocytes, 4173 Chloroplast Collagen synthesis by chondrocytes in suspension culture: Modulation by Chloroplast DNA distribution in parasexual hybrids shown by calcium, 3':5'-cyclic AMP, and prostaglandins, 3864 polypeptide composition of fraction I protein, 5109 Chondroitin sulfate Identification and cloning of chloroplast gene coding for large subunit of Cellular transformation and differentiation: Effect of Rous sarcoma virus ribulose-1,5-bisphosphate carboxylase from Chlamydomonas transformation on sulfated proteoglycan synthesis by chicken reinhardi, 3193 chondrocytes, 4173 In vitro synthesis and processing of a putative precursor for the small Chordotonalorgan subunit of ribulose-l,5-bisphosphate carboxylase of Chlamydomonas Cilia: Active role in sensory transduction, 793 reinhardtii, 1082 Choriogonadotropin Isolation of chloroplast N,N'-dicyclohexylcarbodiimide-binding Proteolytic enzyme activation of rat (ovarian adenylate cyclase, 4857 proteolipid, active in proton translocation, 2375 Specific gonadotropin binding to Pseudomonas maltophilia, 878 Maize chloroplast DNA fragment encoding large subunit of Chorionicgonadotropin ribulosebisphosphate carboxylase, 5487 see Choriogonadotropin Perturbation of chloroplast DNA amounts and chloroplast gene Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5797

Choroid Major adducts formed by reaction of benzo[a]pyrene diol epoxide with Gyrate atrophy of choroid and retina: Deficiency of ornithine DNA in vitro, 5285 aminotransferase in transformed lymphocytes, 5159 Structural identification of major DNA adduct formed by aflatoxin B1 in Chromatin vitro, 1870 Arrangement of subunits in assembled histone H4 fibers, 3772 Chromium Chromatin protein appears during erythroid differentiation of Friend Bonding of FeO2 in hemoglobin and related'dioxygen complexes, 1780 virus-transformed cells, 653 Chromosomal linkage Chromatin protein appears during erythroid differentiation of Friend Theories of quasi-linkage and "affinity": Implications for population virus-transformed cells (correction), 3104 structure, 3513 Chromatin subunits from baker's yeast: Isolation and partial Chromosome characterization, 1343 .Involvement of histone HI in organization of chromosome fiber, 1879 Comparative subunit structure of HeLa, yeast, and chickenl erythrocyte Role of mitotic replication genes in chromosome duplication during chromatin, 79 meiosis, 3951 Crosslinked histone octamer as model of nucleosome core, 2780 Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, Crosslinked histone octamer as model of nucleosome core (correction), 2514 5198 Suppression of production of mouse 28S ribosomal RNA in DNA degradation in terminally differentiating lens fiber cells from chick mouse-human hybrids segregating mouse chromosomes, 694 embryos, 5579 -Chromosome, bacterial Fidelity of synthesis of preribosomal RNA in isolated nucleoli and Chromosomal location of structural gene for RNA polymerase a factor in nucleolar chromatin, 2446 Escherichia coli, 1831 Genes transcribed at diverse rates have similar conformation in DNA fragment containing origin of replication of Escherichia coli chromatin, 4867 chromosome, 2720 Histone gene transcription activated by nonhistone chromosomal Terminus region of chromosome in Escherichia coli inhibits replication proteins in WI-38 human diploid fibroblasts, 173 forks, 3927 Histone H3 disulfide dimers and nucleosome structure, 5519 Chromosome behavior Isopeptide linkage between nonhistone and histone 2A polypeptides of Pathways of genetic transfer from Tripsacum to Zea mays, 3494 chromosomal conjugate-protein A24, 864 Chromosome, human Limited accessibility of chromatin satellite DNA to RNA polymerase Assignment of integration site for simian virus 40 to chromosome 17 in from Escherichia coli, 4337 GM54VA, a human cell line transformed by simian virus 40, 315 5-Methylcytosine in chromatin, 2725 Genetics of connective tissue proteins: Gene for human type I Physical properties of chemically acetylated rat liver chromatin, 3244 procollagen assigned to chromosome 17 by analysis of cell hybrids and Protein A24 in rat liver nucleosomes, 5492 microcell hybrids, 4444 Selective association of trout-specific H6 protein with chromatin regions Human gene for galactose-l-phosphate uridyltransferase assigned to susceptible to DNase I and DNase II: Location of HMG-T in spacer chromosome 9: Studies with Chinese hamster-human somatic cell region between core nucleosomes, 2810 hybrids, 5628 Structure of histone HI-DNA complex: Effect of histone HI on DNA Human mitotic chromosomes: Higher-order structure, 1595 condensation, 4852 Human Y-chromosome-specific reiterated DNA in chromosome variants, Subunit structure of chromatin and organization of eukaryotic highly 1245 repetitive DNA: Nucleosomal proteins associated with highly Major histocompatibility complex assigned to a region of the short arm repetitive mammalian DNA, 3297 of human chromosome 6, 1147 Transcriptionally active chromatin isolated from mammalian nucleoli, 69 Major histocompatibility complex assigned to a region of the short arm Transcription of Xenopus laevis 5S RNA genes in isolated chromatin by of human chromosome 6 (correction), 5776 purified RNA polymerase III, 44 Mannosidosis: Assignment of lysosomal a-mannosidase B gene to Chromatiumvinosum chromosome 19 in man, 2968 Chromatium hydrogenase, 861 Mapping of human chromosomal regions related to neoplasia: Evidence Rates of dissolution of Fe4S4 clusters of Chromatium vinosum from chromosomes 1 and 17, 5729 high-potential iron protein and ferredoxin depend on cluster oxidation Protein scaffold isolated from mitotic HeLa cell chromosomes, 4937 state, 5231 Chromosome, male recombination Chromatography,affinity Genetic instability in Drosophila melanogaster: De novo induction of Adenylate cyclase-free, l-adrenergic receptor isolated from turkey putative insertion mutations, 3490 erythrocyte membranes by affinity chromatography, 3710 Chromosome mapping Affinity alkylation labels two subunits of reduced acetylcholine receptor see also Gene mapping from mammalian muscle, 4685 Chromosome mapping of genes that control differentiation and Binding of mouse interferon to polynucleotides, 3787 malignancy in myeloid leukemic cells, 253 Biotinylinsulins as potential tools for receptor studies, 2697 Chromosome, metaphase Calcium control of actin-activated myosin adenosine triphosphatase from Codominant markers transferred by isolated metaphase chromosomes in Dictyostelium discoideum (correction), 392 Chinese hamster ovary cells, 3480 Erythropoietin: Isolation by affinity chromatography with lectin-agarose Codominant markers transferred by isolated metaphase chromosomes in derivatives, 4633 Chinese hamster ovary cells (correction), 5776 Estradiol receptor of calf uterus: Interaction with heparin-agarose and In vivo analysis of cellular replication, 2041 purification, 4886 Purified complement-fixing antigen identified as Epstein-Barr Eukaryote ribosomes possess a binding site for concanavalin A, 818 virus-determined nuclear antigen by its binding to metaphase Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: chromosomes, 1605 Increased transcription during erythroid differentiation, 2475 Chromosome, mouse Host specificity of serum marker for hepatitis B: "e antigen" has Microcell-mediated transfer of murine chromosomes into mouse, Chinese properties of an immunoglobulin, 1702 hamster, and human somatic cells, 319 3-Hydroxy-3-methylglutaryl-coenzyme A reductase purified from rat Chromosome, polytene liver, 1431 Localization of RNA polymerase in polytene chromosomes of Drosophila Isolation of 7r-alcoholdehydrogenase of human liver: Determinant of melanogaster, 2079 alcoholism? 4378 Chromosome transfer mRNA-directed synthesis of catalytically active mouse /-glucuronidase Stable association of human transgenome and host murine chromosomes in Xenopus oocytes, 4462 demonstrated with trispecific microcell hybrids, 3937 Nucleotide phosphotransferase of Escherichia coli: Purification by Chromosome, X affinity chromatography, 3226 Lymphocyte alloantigens associated with X-chromosome-linked immune Protein-sugar interactions: Preparation, purification, and properties of response genes, 721 rabbit antibodies against di-N-acetylchitobiose, 168 Serial transfer of human gene to rodent cells by sequential Roles of proteins from inner face of plasma membranes in susceptibility chromosome-mediated gene transfer, 2943 of (Na+ + K+)-stimulated Mg2+ adenosinetriphosphatase to ouabain, Chromosome, yeast 633 Folded chromosomes isolated from yeast Saccharomyces cerevisiae, 2850 Surface differentiation antigens of human mammary epthelial cells Genetic evidence for inducibility of recombination competence in yeast, carried on human milk fat globule, 582 1667 Transmembrane bridging proteins identified in plasma membrane of Chrysomelidial cultured mouse L cells, 5341 Methylcyclopentanoid terpenes from larval defensive secretion of a Chromatography, column chrysomelid beetle (Plagiodera versicolora), 2189 Protein covalently linked to poliovirus genome RNA, 59 Chylomicron Chromatography,diazobenzyloxymethyl-paper Intestine as a source of apolipoprotein A1, 2569 Detection of specific RNAs in agarose gels by transfer to Chymosin(EC 3.4.23.4) diazobenzyloxymethyl-paper and hybridization with DNA probes, 5350 Prochymosin: Complete amino acid sequence, 2321 Chromatography,hydroxylapatite Chymotrypsin,monoacetyl- Glucocorticoid-stimulated accumulation of mouse mammary tumor virus Kinetic evidence for an intermediate in deacetylation of RNA: Increased rate of synthesis of viral RNA, 2879 monoacetyl-chymotrypsin, 510 Chromatography,liquid Cigarettesmoker Electrogenic K+/Ca2+ ionophore isolated from an ionophoroprotein of Concentration of mutagens from urine by adsorption with nonpolar resin beef heart mitochondria, 3667 XAD-2: Cigarette smokers have mutagenic urine, 3555 Isolation and characterization of opioid peptides from rat pituitary: Cilia 1/-Lipotropin, 3052 Cilia: Active role in sensory transduction, 793 Isolation and characterization of opioid peptides from rat pituitary: Direction of active sliding of microtubules in Tetrahymena cilia, 2045 (-Endorphin, 4969 Downloaded by guest on September 27, 2021 5798 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Ciliary row Reduction of blood pressure and vascular collagen in hypertensive rats Ciliary rows: 180? rotation and its morphogenetic implications in by /-aminopropionitrile, 360 Tetrahymena pyriformis, 1115 Specific changes in collagen phenotype of BALB 3T3 cells: Result of Circadian rhythm transformation by sarcoma viruses or a chemical carcinogen, 2933 see also Biological clock Synthesis of two collagen types of embryonic chick corneal epithelium in Mutual entrainment of bilaterally distributed circadian pacemakers, vitro, 39 1277 Transitions in collagen types during matrix-induced cartilage, bone, and Circular dichroism bone marrow formation, 5589 Circular dichroism of adenosine dinucleotides, 1785 Triple-helix formation on ribosome-bound nascent chains of procollagen: Conformation of /-endorphin and /-lipotropin: Formation of helical Deuterium-hydrogen exchange studies, 902 structure in methanol and sodium dodecyl sulfate solutions, 3235 Collagenase Human somatotropin: Restoration of full biological activity by Granulocyte collagenase: Selective digestion of type I relative to type III noncovalent interaction of natural and synthetic fragment of the collagen, 897 hormone, 1016 Granulocyte collagenase: Selective digestion of type I relative to type III Identification of /,/-turns and unordered conformations in polypeptide collagen (correction), 2594 chains by vacuum ultraviolet circular dichroism, 3208 Recessive dystrophic epidermolysis bullosa: Evidence for altered Cistron collagenase in fibroblast cultures, 4646 Lens a-crystallin 14S mRNA: Bicistronic nature, 5448 Collagenase (EC 3.4.24.3) Citrate Prostaglandin regulation of macrophage collagenase production, 4955 Acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in Columbia livia liver cell, 1497 Parental investment, mate choice, and mate quality, 3476 Cloud seeding Specific projection of displaced retinal ganglion cells upon accessory Weather modification technology: Statistician's view (Review), 4714 optic system in pigeon (Columbia livia), 1753 Cobalamin Combinatorial identity Intracellular binding of radioactive hydroxocobalamin to MacMahon's conjecture on symmetric plane partitions, 426 cobalamin-dependent apoenzymes in rat liver, 916 Compact mapping Recognition of two intracellular cobalamin binding proteins and their Sharpened form of Schauder fixed-point theorem, 4749 identification as methylmalonyl-CoA mutase and methionine Competing risks synthetase, 921 Nonidentifiability in stochastic models of illness and death, 1338 Cobalamin, adenosyl- Complement Biochemical catalysis involving coenzyme B-12: Mechanistic Alternative complement pathway activated due to resistance of I interpretation of vicinal interchange rearrangements, 811 zymosan-bound amplification convertase to endogenous regulatory Cobalamin, hydroxo- mechanisms, 1683 Intracellular binding of radioactive hydroxocobalamin to Cell-free synthesis of fourth component of guinea pig complement (C4): cobalamin-dependent apoenzymes in rat liver, 916 Identification of precursor of serum C4 (pro-C4), 1707 Cobalt Cleavage of C2 by Cls into antigenically distinct fragments C2a and C2b: Structure of transition-metal cluster compounds: Use of additional Binding of C2b to C4b, 2998 orbital resulting from f, g character of spd bond orbitals, 5235 C-reactive protein and complement subcomponent Clt characterized as Cobalt protein homologous proteins diplaying cyclic pentameric symmetry Biochemical catalysis involving coenzyme B-12: Mechanistic (pentraxins), 739 interpretation of vicinal interchange rearrangements, 811 C-reactive protein and complement interact with liposomes, 5672 Cochlea Heterogeneity of nephritic factor and its identification as an Carbonic anhydrase from the inner ear of guinea pig: Purification, 892 immunoglobulin, 3980 Cockroach Membrane-controlled depletion of complement activity by see Arnivaga investigata; Leucophaea maderae spin-label-specific IgM, 3537 Codon Partial amino-acid sequences of human and rabbit C-reactive proteins: Codon specificity of UGA suppressor tRNATrP from Escherichia coli, Homology with immunoglobulins and histocompatibility antigens, 5496 1214 Coenzyme B-12 Structural heterogeneity of C2 complement protein and its genetic see Cobalamin, adenosyl- variants in man: New polymorphism of HLA region, 1672 Colchicine Synthetic peptides with biological activities and specificity of human Addition of colchicine-tubulin complex to microtubule ends: Mechanism C3a anaphylatoxin, 1826 of substoichiometric colchicine poisoning, 3466 Third complement protein and cell surface macromolecules: Interaction, Changes in membrane microviscosity associated with phagocytosis: 2701 Effects of colchicine, 1072 Complex submanifold Colchicine affects cyclic AMP levels in human leukocytes, 3404 Complex submanifolds in real-analytic pseudoconvex hypersurfaces, 3126 In vitro assembly of pure tubulin into microtubules in absence of Computer analysis microtubule-associated proteins and glycerol, 1860 Nucleic acid regulatory sequences: Computer analysis, 4401 Isolation and preliminary characterization of 10-nm filaments from baby Computer code hamster kidney (BHK-21) cells, 2422 Method of computational magnetohydrodynamics defining stable Scyllac Role of surface modulating assemblies in growth control of normal and equilibria, 393 transformed fibroblasts, 666 Computer simulation Variants of 3T3 cells lacking mitogenic response to epidermal growth How to label nerve cells so that they can interconnect in an ordered factor, 3918 fashion, 5176 Colicin Ia Concanavalin A Affinity of intact Escherichia coli for hydrophobic membrane probes is a Antigen-specific purification of blocking factors from sera of mice with function of the physiological state of cells, 1811 chemically induced tumors, 4605 Collagen Enzyme replacement therapy in Gaucher's disease: Large-scale see also Connective tissue; Procollagen purification of glucocerebrosidase suitable for human administration, Biosynthesis of type I and III collagens by cultured smooth muscle cells 3560 from human aorta, 671 Eukaryote ribosomes possess a binding site for concanavalin A, 818 Cell surface-associated structural proteins in connective tissue cells, 2480 Glycophorin and the concanavalin A receptor of human erythrocytes: Collagen biosynthesis in blood vessels and other tissues reduced by Receptor function in lipid bilayers, 2751 reserpine and hypophysectomy, 777 Rates of aggregation, loss of anchorage dependence, and tumorigenicity Collagen degradation in rat skin but not in intestine during rapid of cultured cells, 258 growth: Effect on collagen types I and III from skin, 1436 Receptor diffusion on cell surfaces modulated by locally bound Collagen synthesis by chondrocytes in suspension culture: Modulation by concanavalin A, 1110 calcium, 3':5'-cyclic AMP, and prostaglandins, 3864 Role of surface modulating assemblies in growth control of normal and Dependence of differentiated state on cellular environment: Modulation transformed fibroblasts, 666 of collagen synthesis in tendon cells, 4453 Suppression of immunoglobulin synthesis and secretion by peripheral Granulocyte collagenase: Selective digestion of type I relative to type III blood lymphocytes from normal donors, 2099 collagen, 897 Concanavalin A, succinyl Granulocyte collagenase: Selective digestion of type I relative to type III Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit collagen (correction), 2594 synthesis of brain-specific protein in rat glial cells, 3855 Hexamethylene bisacetamide induces morphologic changes and increased Conditioning synthesis of procollagen in cell line from glioblastoma multiforme, Behavior-genetic analysis of Phormia regina: Conditioning, reliable 5060 individual differences, and selection, 5193 Homology between prolyl hydroxylase subunit and tissue protein that Configuration interaction crossreacts immunologically with the enzyme, 4420 Electron affinity of methyl radical: Structures of CH3 and CH3-, 410 Hormonal effects on intracellular and secreted casein in cultures of Conformation mouse mammary epithelial cells on floating collagen membranes, 4466 see also Protein conformation Levels of translatable mRNAs for cell surface protein, collagen Heat capacity and entropy changes in processes involving proteins, 2236 precursors, and two membrane proteins are altered in Rous sarcoma Structure of proteins: Packing of o-helices and pleated sheets, 4130 virus-transformed chick embryo fibroblasts, 3399 Conformational energy Ordering of cyanogen bromide peptides of type III collagen based on Enkephalin:'Conformational analysis by empirical energy calculations, homology to type I collagen: Preservation of sites for crosslink 414 formation during evolution, 84 Local interactions in bends of proteins, 4126 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) SubjectIndex 5799

Tertiary structural change in hemoglobin: Mechanism, 801 Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by Conformationaltransition its effects on cell membrane, 392 Kinetic evidence for hapten-induced conformational transition in Protease inhibitor blocks SOS functions in Escherichia coli: Antipain immunoglobulin MOPC 460 (correction), 1301 prevents X repressor inactivation, ultraviolet mutagenesis, and Conjugatepoint filamentous growth, 2594 Tubular presentations 7rof subsets of manifolds, 2209 Stereochemistry of polymerization by DNA-dependent RNA-polymerase Connectivetissue from Escherichia coli: Investigation with a diastereomeric see also Collagen; Procollagen ATP-analogue, 392 Biosynthesis of type I and III collagens by cultured smooth muscle cells Structure of a large segment of the genome of simian virus 40 that does from human aorta, 671 not encode known proteins, 2594 Cell surface-associated structural proteins in connective tissue cells, 2480 5'-Terminal 7-methylguanosine and mRNA function: Influence of Collagen degradation in rat skin but not in intestine during rapid potassium concentration on translation in vitro, 5198 growth: Effect on collagen types I and III from skin, 1436 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Fibroblast heterogeneity and prostaglandin regulation of subpopulations, activity by choline: Choline administration can increase cholinergic 3429 transmission, 2594 Granulocyte collagenase: Selective digestion of type I relative to type III Corticosteroid collagen, 897 Dephosphorylation inactivates glucocorticoid receptors, 1398 Granulocyte collagenase: Selective digestion of type I relative to type III Corticotropin collagen (correction), 2594 Angiotensin stimulation of bovine adrenocortical cell growth, 5569 Transitions in collagen types during matrix-induced cartilage, bone, and Common precursor to corticotropins and endorphins, 3014 bone marrow formation, 5589 Common precursor to corticotropin and /-lipotropin: Cell-free synthesis Connectivity of precursor and identification of. corticotropin peptides in the Theory of connectivity for formally symmetric operators, 4722 molecule, 4826 Convexprogram Common precursor to corticotropin and /-lipotropin: Identification of Convex programs having some linear constraints, 26 /-lipotropin peptides and their arrangement relative to corticotropin Cooperativity in precursor synthesized in cell-free system, 5300 Tertiary structural change in hemoglobin: Mechanism, 801 Corticotropin in brain of normal and hypophysectomized rats, 648 Coordinatecontrol Glucocorticoid effect on level of corticotropin messenger RNA activity in Magnesium and calcium effects on uptake of hexoses and uridine by rat pituitary, 3283 chick embryo fibroblasts, 1585 /-Lipotropin: Localization of cells and axons in rat brain by Copper immunocytochemistry, 5155 Blue copper proteins: Synthesis, spectra, and structures of CuIN3(SR) and Steroidogenic activity of fragments of adrenocorticotropin with arginine Cu"N3(SR) active site analogues, 3114 in residue positions 3 and 5, 4329 Proteolytic cleavage causes heterogeneity present in human Cortisol ceruloplasmin preparations: Chemical evidence, 5377 Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in X-ray absorption edge studies on oxidized and reduced cytochrome c liposomes, 1580 oxidase, 3821 Cosmology Cornealmorphogenesis Galaxies: Outstanding problems and instrumental prospect. for the Synthesis of two collagen types of embryonic chick corneal epithelium in coming decade (Review), 1767 vitro, 39 Crab Corpuscallosum see Cancer antennarius Stimpson; Carcinus; Pachygrapsus crassipes Active touch exploration of extrapersonal space elicits specific Randall electrogenesis in right cerebral hemisphere of intact right-handed man, Creatinekinase (EC 2.7.3.2) 4037 Radioimmunoassay of creatine kinase-B isoenzyme in human sera: Corrections Results in patients with acute myocardial infarction, 1711 Amino-terminal sequences of two polypeptides from human serum with Crotonaldehyde nonsuppressible insulin-like and cell-growth-promoting activities: Electron spin resonance absorption of tissue constituents, 1558 Structural homology with insulin B chain, 1301 Crowngall disease Anionic glycopeptides and glycosaminoglycans synthesized by embryonic Epigenetic variation of cultured somatic cells: Gradual changes in neural tube and neural crest, 4076 requirement for factors promoting cell division, 2928 Calcium control of actin-activated myosin adenosine triphosphatase from Thermosensitive step associated with transfer of Ti plasmid during Dictyostelium discoideum, 392 conjugation: Relation to transformation in crown gall, 2848 Chromatin protein appears during erythroid differentiation of Friend Cryoenzymology virus-transformed cells, 3104 Cryoenzymology in mixed solvents without cosolvent effects on enzyme Codominant markers transferred by isolated metaphase chromosomes in specific activity, 2297 Chinese hamster ovary cells, 5776 Cryoglobulin Crosslinked histone octamer as model of nucleosome core, 5198 Waldenstrom macroglobulin that is a cold agglutinin and a cryoglobulin Crystallography of new ternary borides, 3621 because it binds N-acetylneuraminosyl residues, 4591 3':5'-Cyclic AMP: Independent induction of amino acid transport by Crystalgrowth inhibition epinephrine in primary cultures of adult rat liver cells, 2187 Adsorption inhibition as mechanism of freezing resistance in polar fishes, Dynamic properties of isolated acetylcholine receptor proteins: Release 2589 of calcium ions caused by acetylcholine binding, 1763 a-Crystallin Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich Lens a-crystallin 14S mRNA: Bicistronic nature, 5448 in sucrose, 3550 CTP(ATP):tRNAnucleotidyltransferase Granulocyte collagenase: Selective digestion of type I relative to type III Isomeric aminoacyl-tRNAs are both bound by elongation factor Tu, 437 collagen, 2594 C-type virus Human myasthenia gravis: Electrophysiological and ultrastructural Antigen-specific nonimmunoglobulin factor that neutralizes xenotropic evidence compatible with antibody attachment to acetylcholine virus is associated with mouse serum lipoproteins, 276 receptor complex, 1301 Chemical transformation of rat cell infected with xenotropic type-C Identification of spacer tRNA genes in individual ribosomal RNA RNA virus and its suppression by virus-specific antiserum, 579 transcription units of Escherichia coli, 4706 Evolution of primate oncornaviruses: Endogenous virus from langurs Independent expression of adrenergic phenotype by neural crest cells in (Presbytis spp.) with related virogene sequences in other Ole World vitro, 4706 monkeys, 4557 Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface Friend strain of spleen focus-forming virus is recombinant between membranes, 4706 ecotropic murine type C virus and enu gene region of xenotropic type Intramolecular general base-catalyzed ester hydrolyses by imidazolyl C virus, 4671 group, 3621 Humoral immune response of NIH Swiss and SWR/J mice to vaccination lonophores stimulate prostaglandin and thromboxane biosynthesis, 5778 with formalinized AKR or Gross murine leukemia virus, 343 Kinetic evidence for hapten-induced conformational transition in Immunoprevention of x-ray-induced leukemias in C57BL mouse, 1697 immunoglobulin MOPC 460, 1301 MCF murine leukemia viruses are envelope (enu) gene recombinants: Major histocompatibility complex assigned to a region of the short arm Biochemical evidence, 4676 of human chromosome 6; 5776 Natural human antibodies reactive with primate type-C viral antigens, Methanogenic bacteria classified by 16S ribosomal RNA 1237 characterization, 5778 Polypeptides of cells transformed by RNA or DNA tumor viruses, 2729 Method for cloning eukaryotic structural gene sequences, 2187 Rauscher-leukemia-virus-related sequences in human DNA: Presence in Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during some tissues of some patients with hematopoietic neoplasias and cell cycle of mouse mastocytoma cells, 3621 absence in DNA from other tissues, 353 National Academy of Sciences USA: Classes, council, members, officers, Segregation of genetic information for a B-tropic leukemia virus with the sections, 1301 structural locus for BALB:virus-1, 2953 Nerve growth factor in mouse serum and saliva: Role of submandibular Streptozotocin-induced insulitis and diabetes, 2485 gland, 4706 Type C RNA virus isolated from an established human histiocytic Neurotensin: Immunohistochemical localization in rat central nervous lymphoma cell line, 2564 system, 5777 Cubiclattice Nuclear magnetic resonance studies of interaction of general anesthetics Extended Watson integrals for cubic lattices, 1800 with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer, 3621 Cyanobacterium Physical-chemical approach to transient change in Na ion conductivity see also Oscillatoria limnetica of excitable membranes, 3621 Cyanobacterial phycobilisomes: Molecular composition, 1635 Downloaded by guest on September 27, 2021 5800 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Cyanogenbromide peptide Cytosine,5-methyl- Internal deletion mutant of a myosin heavy chain in Caenorhabditis 5-Methylcytosine in chromatin, 2725 elegans, 5336 Cytotoxicity Ordering of cyanogen bromide peptides of type III collagen based on Moloney leukemia virus-induced cell surface antigen: Detection and homology to type I collagen: Preservation of sites for crosslink characterization in sodium dodecyl sulfate gels, 5270 formation during evolution, 84 Mutagenicity and cytotoxicity of benz[a]anthracene diol epoxides and Cyclic AMP tetrahydro-epoxides: Exceptional activity of bay region 1,2-epoxides, see Adenosine 3':5'-cyclic monophosphate 2746 Cyclic GMP Cytotoxicity,cell-mediated see Guanosine 3':5'-cyclic monophosphate Development of tumor cell resistance to syngeneic cell-mediated 2':3'-Cyclic-nucleosidemonophosphatephosphodiesterase (EC 3.1.4.16) cytotoxicity during growth of ascitic mastocytoma P815Y, 329 Norepinephrine induces glial-specific enzyme activity in cultured glioma Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: cells, 4501 Evidence for T cell interactions, 5667 2':3'-Cyclicnucleotide3'-phosphohydrolase Cytotoxicresponse see 2':3'-Cyclic-nucleotide monophosphate phosphodiesterase Heterogeneity of cytotoxic response of thymus-derived lymphocytes after Cycloheximide immunization with influenza viruses, 1209 Induction and decay of human fibroblast interferon mRNA, 4415 Retinoic acid (vitamin A acid) induced transcriptional control of interferon production, 5382 Dane particle Cyclonicmean circulation Association of e antigen with Dane particle DNA in sera from Cyclonic mean circulation of large lakes, 2204 asymptomatic carriers of hepatitis B surface antigen, 2149 Cyclonucleotide Data noise reduction Spatial configuration of ordered polynucleotide chains: A novel double Robust nonlinear data smoothers: Definitions and recommendations, 434 helix, 1775 Defective interfering particle L-Cysteine,N-acetyl- 3' Terminus of RNA isolated from vesicular stomatitis virus and from its Nuclear coupling of 33S and nature of free radicals in irradiated crystals defective interfering particles, 1353 of N-acetyl-L-cysteine, 216 Deformation Cystic fibrosis Deformations of instantons, 2662 Cystic fibrosis fibroblasts: Increased resistance to ouabain toxicity, 1676 Dehydrogenation Increased dexamethasone resistance of cystic fibrosis fibroblasts, 5642 Dehydrogenase and transhydrogenase properties of soluble NADH Cystine dehydrogenase of bovine heart mitochondria, 846 Cystinotic fibroblasts accumulate cystine from intracellular protein 5-Dehydroquinatedehydratase (EC 4.2.1.10) degradation, 4505 De novo synthesis of qa enzymes of Neurospora crassa during induction, Cystinosis 4256 Cystinotic fibroblasts accumulate cystine from intracellular protein Expression in Escherichia coli K-12 of structural gene for catabolic degradation, 4505 dehydroquinase of Neurospora crassa, 3508 CytochalasinB Demecolcine Cells reconstituted from cell fragments of two different species multiply Bovine brain filament antibody localized on intermediate (100 A) and form colonies, 606 filaments in guinea pig vascular endothelial cells and chick cardiac Microsurgically produced homozygous-diploid uniparental mice, 5657 muscle cells, 662 Selection of reconstituted cells from karyoplasts fused to Demographicstability chloramphenicol-resistant cytoplasts, 2461 Measures of fitness and demographic stability, 384 CytochromeP-450 Demography Hepatic mitochondrial cytochrome P-450: Isolation and functional Generalizing Fisher's "reproductive value": Linear differential and characterization, 5477 difference equations of "dilute" biological systems, 5189 Picosecond dynamics of iron proteins, 4139 Generalizing Fisher's "reproductive value": Nonlinear, homogeneous, Regulation of heme pathway enzymes and cellular glutathione content biparental systems, 5772 by metals that do not chelate with tetrapyrroles: Blockade of metal Demyelinatingdisease effects by thiols, 1875 Density of sodium channels in mammalian myelinated nerve fibers and Cytochrome b5 nature of axonal membrane under myelin sheath, 211 Charge shift electrophoresis: Method for distinguishing between Dendrobateshistrionicus amphiphilic and hydrophilic proteins in detergent solution, 529 Perhydrohistrionicotoxin: Potential ligand for ion conductance Cytochrome b5: Primary structure of membranous segment, 3725 modulator of acetylcholine receptor, 2172 Excited state lifetimes in cytochromes measured from Raman scattering Denervationhypersensitivity data: Iron-porphyrin interactions, 2607 L-3,4-Dihydroxyphenylalanine-induced hypersensitivity simulating Cytochrome c features of denervation, 2126 Electron transfer: Experimental verification of vibronically coupled Density electron tunneling, 3817 Simultaneous measurements of viscosity and density in solutions Excited state lifetimes in cytochromes measured from Raman scattering undergoing change, 4430 data: Iron-porphyrin interactions, 2607 Density matrix Pressure affects visible spectra of complexes of myoglobin, hemoglobin, Quantum statistical theory of optical phenomena, 3105 cytochrome c, and horse radish peroxidase, 1 Density wave theory Semisynthetic cytochrome c, 4248 Discrete spiral modes in disk galaxies: Numerical examples based on Structure of cytochrome c555of Chlorobium thiosulfatophilum: Primitive density wave theory, 4726 low-potential cytochrome c, 5244 Deoxycytidine deaminase (EC 3.5.4.5) Vibronically coupled tunneling description of biological electron transfer: Deoxycytidine deaminase activity induced in mammalian cell lines by Experimental test, 229 infection with herpes simplex virus type 1, 1734 Cytochrome c oxidase (EC 1.9.3.1) 5'-Deoxypyridoxal Coupling in cytochrome c oxidase, 3662 5'-Deoxypyridoxal as a potential anti-sickling agent, 1721 Deuterium magnetic resonance studies of interaction of lipids with Deoxyribonuclease membrane proteins, 5435 Embryonic chicken brain and mouse neuroblastoma cells NIE-115 and Oxygen intermediates and mixed valence states of cytochrome oxidase: N-18 contain an inhibitor of acid deoxyribonuclease, 842 Infrared absorption difference spectra of compounds A, B, and C of DeoxyribonucleaseI cytochrome oxidase and oxygen, 4777 Genes transcribed at diverse rates have similar conformation in Oxygen "pulsed" cytochrome c oxidase: Functional properties and chromatin, 4867 catalytic relevance, 3128 DeoxyribonucleaseI (EC 3.1.4.5) X-ray absorption edge studies on oxidized and reduced cytochrome c Comparative subunit structure of HeLa, yeast, and chicken erythrocyte oxidase, 3821 chromatin, 79 Cytokinesis Deoxyribonucleicacid Inhibition of cytokinesis in Friend leukemia cells by membrane mobility see also Nucleic acid agents, 2884 DNA degradation in terminally differentiating lens fiber cells from chick Cytokininhabituation embryos, 5579 Epigenetic variation of cultured somatic cells: Gradual changes in Polylysine used for adsorption of nucleic acids and enzymes to electron requirement for factors promoting cell division, 2928 microscope specimen films, 2311 Cytology Purified DNAs are transcribed after microinjection into Xenopus Pathways of genetic transfer from Tripsacum to Zea mays, 3494 oocytes, 1502 Cytolysis Structural identification of major DNA adduct formed by aflatoxin B 1 in Calcium dependence of glucocorticoid-induced lymphocytolysis, 638 vitro, 1870 Cytoplasmicinheritance Transient accumulation of Okazaki fragments as a result of uracil Chloroplast DNA distribution in parasexual hybrids shown by incorporation into nascent DNA, 154 polypeptide composition of fraction I protein, 5109 Deoxyribonucleicacid, bacterial Inheritance of selected pathotoxin resistance in maize plants regenerated Contacts between lac repressor and thymines in lac operator, 4973 from cell cultures, 5113 Release of Escherichia coli DNA from membrane complexes by Unique DNA associated with mitochondria in "S"-type cytoplasm of single-strand endonucleases, 2756 male-sterile maize, 2904 Replication and expression of plasmids from Staphylococcus aureus in Cytoplast Bacillus subtilis, 1680 Selection of reconstituted cells from karyoplasts fused to Deoxyribonucleicacid binding chloramphenicol-resistant cytoplasts, 2461 Nonspecific DNA binding of genome-regulating proteins as biological Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5801

control mechanism: Measurement of DNA-bound Escherichia coli lac Deoxyribonucleicacid nucleotidyltransferase,ribonucleic acid-dependent repressor in vivo, 4228 DNA polymerase of human breast cancer particles: Purification and Deoxyribonucleic acid binding protein characterization, 764 DNA or RNA priming of bacteriophage G4 DNA synthesis by Nucleotide sequence at 5' terminus of avian sarcoma virus genome, 1473 Escherichia coli dnaG protein, 2815 Synthesis of full-length DNA copies of avian myeloblastosis virus RNA Integration protein of bacteriophage A is a site-specific DNA-binding in hgh yields, 2840 protein, 1511 tRNA rp (bovine) binding to reverse transcriptase of avian Deoxyribonucleic acid, chloroplast myeloblastosis virus and function as a heterologous primer, 1889 Chloroplast DNA distribution in parasexual hybrids shown by Type C RNA virus isolated from an established human histiocytic polypeptide composition of fraction I protein, 5109 lymphoma cell line, 2564 Identification and cloning of chloroplast gene coding for large subunit of Deoxyribonucleicacid nucleotidyltransferase,ribonucleic acid-dependent ribulose-1,5-bisphosphate carboxylase from Chlamydomonas (EC 2.7.7.7) reinhardi, 3193 Rous sarcoma virus genome is terminally redundant: The 3' sequence, Maize chloroplast DNA fragment encoding large subunit of 994 ribulosebisphosphate carboxylase, 5487 Terminally repeated sequences in avian sarcoma virus RNA genome, Perturbation of chloroplast DNA amounts and chloroplast gene 2389 transmission in Chlamydomonas reinhardtii by 5-fluorodeoxyuridine, Deoxyribonucleicacid polymerase 4552 see Deoxyribonucleic acid nucleotidyltransferase Deoxyribonucleic acid, circular Deoxyribonucleicacid-protein interaction Bidirection replication from a unique origin in a mini-F plasmid, 1138 Secondary structural complementarity between DNA and proteins, 1458 Physical mapping of a DNA sequence common to plasmids of Deoxyribonucleicacid, recombinant incompatibility group F 1, 1190 see also Gene cloning; Hybridization, molecular; Molecular cloning Deoxyribonucleic acid, cleavage Aminoglycoside-modifying enzyme of antibiotic-producing bacterium Cleavage map of linear mouse sarcoma virus DNA, 29 acts as determinant of antibiotic resistance in Escherichia coli, 999 Deoxyribonucleic acid, complementary Chemotaxis in Escherichia coli: Methylation of che gene products, 3317 Authentic /-globin mRNA sequences in homozygous /?-thalassemia, Cloning and mapping of replication origin of Escherichia coli, 5458 3047 Cloning of immunoglobulin variable region gene from mouse embryo, Histone gene transcription activated by nonhistone chromosomal 3518 proteins in WI-38 human diploid fibroblasts, 173 Cloning of silk fibroin gene and its flanking sequences, 5363 Multihormonal induction of hepatic (2u-globulin mRNA measured by Cloning specific segments of mammalian genome: Bacteriophage X hybridization to complementary DNA, 4791 containing mouse globin and surrounding gene sequences, 4406 Relative stability of (- and /-globin messenger RNAs in homozygous /+ DNA-dependent RNA polymerase involved in a recA-independent thalassemia, 3960 pathway of genetic recombination in Escherichia coli, 3932 Synthesis of full-length DNA copies of avian myeloblastosis virus RNA Expression in Escherichia coli K-12 of structural gene for catabolic in high yields, 2840 dehydroquinase of Neurospora crassa, 3508 Deoxyribonucleic acid condensation Filamentous coliphage M13 as cloning vehicle: Insertion of HindII Structure of histone H1-DNA complex: Effect of histone H1 on DNA fragment of lac regulatory region in M13 replicative form in vitro, condensation, 4852 3642 Deoxyribonucleic acid damage Functional eukaryotic enzyme produced in Escherichia coli: Cloning and Protein X is product of recA gene of Escherichia coli, 5275 expression of yeast structural gene for imidazoleglycerolphosphate Pyrimidine dimers in DNA can give rise to tumors, 5574 dehydratase (his 3), 5255 Deoxyribonucleic acid excision Functional expression of cloned yeast DNA in Escherichia coli, 487 State of prophage Mu DNA upon induction, 3143 Genetic analysis of host range mutant viruses suggests uncoating defect Deoxyribonucleic acid gyrase in simian virus 40-resistant monkey cells, 3503 Mechanism of action of nalidixic acid: Purification of Escherichia coli Isolation and characterization of XpolA transducing phage, 5632 nalA gene product and its relationship to DNA gyrase arnda Method for cloning eukaryotic structural gene sequences (correction), nicking-closing enzyme, 4767 2187 Nalidixic acid resistance: A second genetic character involved in DNA Packaging recombinant DNA molecules into bacteriophage particles in gyrase activity, 4772 vitro, 3259 Role of DNA gyrase in OsXreplicative-form replication in vitro, 1965 pBR345 plasmid DNA: Origin of replication, 5265 Deoxyribonucleic acid, human Sequences homologous to ribosomal insertions occur in Drosophila Human Y-chromosome-specific reiterated DNA in chromosome variants, genome outside the nucleolus organizer, 4233 1245 Structural gene identification and mapping by DNA-mRNA Rauscher-leukemia-virus-related sequences in human DNA: Presence in hybrid-arrested cell-free translation, 4370 some tissues of some patients with hematopoietic neoplasias and Terminus region of chromosome in Escherichia coli inhibits replication absence in DNA from other tissues, 353 forks, 3927 Deoxyribonucleic acid, inverted repeated sequences Transcription termination at trp operon attenuators of Escherichia coli Gene-sized DNA molecules of Oxytricha macronucleus have the same and Salmonella typhimurium: RNA secondary structure and terminal sequence, 4325 regulation of termination, 4365 Mapping of inverted repeated DNA sequences within genome of simian Translation of Drosophila melanogaster sequences in Escherichia coli, virus 40, 1631 5041 Deoxyribonucleic acid, lac operator Variable and constant parts of immunoglobulin light chain gene of a Binding of synthetic lactose operator DNAs to lactose repressors, 3292 mouse myeloma cell are 1250 nontranslated bases apart, 5652 Deoxyribonucleic acid ligase Deoxyribonucleicacid, reiteratedsequence see Polydeoxyribonucleotide synthetase (ATP) Human Y-chromosome-specific reiterated DNA in chromosome variants, Deoxyribonucleic acid, mitochondrial 1245 Expression of petite mitochondrial DNA in vivo: Zygotic gene rescue, Hybridization properties of immunoglobulin mRNA: Failure to detect 2715 covalently associated IgG mRNA transcripts of reiterated and unique Protein structure of probable membrane derivation associated with mouse DNA, 3528 HeLa cell mitochondrial DNA near its origin of replication, 1348 Subunit structure of chromatin and organization of eukaryotic highly Unique DNA associated with mitochondria in "S"-type cytoplasm of repetitive DNA: Nucleosomal proteins associated with highly male-sterile maize, 2904 repetitive mammalian DNA, 3297 Deoxyribonucleic acid nicking-closing enzyme Deoxyribonucleicacid release DNA nicking-closing enzyme encapsidated in vaccinia virus: Partial Kinetics of cell death and disintegration in human lymphocyte cultures, purification and properties, 1841 2536 Mechanism of action of nalidixic acid: Purification of Escherichia coli Deoxyribonucleicacid repair nalA gene product and its relationship to DNA gyrase and a see also Excision repair nicking-closing enzyme, 4767 Differences in removal of acetylaminofluorene and pyrimidine dimers Renaturation of complementary single-stranded DNA circles: Complete from DNA of cultured mammalian cells, 1553 rewinding facilitated by DNA untwisting enzyme, 5328 Different rate-limiting steps in excision repair of ultraviolet- and Deoxyribonucleic acid nucleotidylexotransferase (EC 2.7.7.31) N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human Terminal deoxynucleotidyl transferase in thymocytes demonstrated by fibroblasts, 1548 immunofluorescence, 734 Mutant of Escherichia coli showing constitutive expression of lysogenic Terminal deoxynucleotidyltransferase: Intracellular distribution in rat induction and error-prone DNA repair pathways, 300 bone marrow and thymus, 3993 Partial inhibition of postreplication repair and enhanced frequency of Deoxyribonucleicacid nucleotidyltransferase chemical transformation in rat cells infected with leukemia virus, 238 Enzymatic initiation of DNA synthesis by yeast DNA polymerases, 1937 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Isolation and characterization of XpolA transducing phage, 5632 prevents A repressor inactivation, ultraviolet mutagenesis, and Deoxyribonucleicacid nucleotidyltransferase(EC 2.7.7.7) filamentous growth, 1152 Antigenic relatedness of DNA polymerase of human breast cancer Protease inhibitor blocks SOS functions in Escherichia coli: Antipain particles to enzyme of Mason-Pfizer monkey virus, 2144 prevents X repressor inactivation, ultraviolet mutagenesis, and Cell-free synthesis of precursor polypeptide for avian myeloblastosis filamentous growth (correction), 2594 virus DNA polymerase, 4951 Deoxyribonucleicacid replication Replication of duplex DNA by bacteriophage T7 DNA polymerase and Cell cycle of Saccharomyces cerevisiae in populations growing at gene 4 protein is accompanied by hydrolysis of nucleoside different rates, 3850 5'-triphosphates, 1525 Early simian virus 40 transcriptional complexes: Late transcription in absence of detectable DNA replication, 5443 Downloaded by guest on September 27, 2021 5802 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Enzyme associations in T4 phage DNA precursor synthesis, 3152 Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface Large-scale automated isolation of Escherichia coli mutants with membranes, 2251 thermosensitive DNA replication, 3485 Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface Mechanism of action of nalidixic acid: Purification of Escherichia coli membranes (correction), 4706 nalA gene product and its relationship to DNA gyrase and a Medium composition affects protein degradation and DNA synthesis in nicking-closing enzyme, 4767 rat embryo fibroblasts, 2427 Mechanism of duplex DNA replication revealed by enzymatic studies of Regulation of DNA synthesis: Age-dependent cooperation among G1l phage 4X174: Catalytic strand separation in advance of replication, cells upon fusion, 2869 193 Regulatory function of simian virus 40 DNA replication for late viral Migration of Escherichia coli dnaB protein on template DNA strand as gene expression, 4831 mechanism in initiating DNA replication, 4190 Synthesis of full-length DNA copies of avian Inyeloblastosis virus RNA Mutator action by Escherichia coli strains carrying dnaE mutations, in high yields, 2840 3947 Temporal sequence of hormonal interactions during prereplicative phase Nalidixic acid resistance: A second genetic character involved in DNA of quiescent cultured 3T3 fibroblasts, 3845 gyrase activity, 4772 Terminally repeated sequences in avian sarcoma virus RNA genome, Origin of replication of colicin El plasmid DNA, 1865 2389 pBR345 plasmid DNA: Origin of replication, 5265 Terminal redundancy and origin of replication of Rous sarcoma virus Replication of adenovirus type 2 DNA in vitro, 4425 RNA, 1908 Replication of duplex DNA by bacteriophage T7 DNA polymerase and Deoxyribonucleic acid untwisting enzyme gene 4 protein is accompanied by hydrolysis of nucleoside Renaturation of complementary single-stranded DNA circles: Complete 5'-triphosphates, 1525 rewinding facilitated by DNA untwisting enzyme, 5328 (X174 cistron A protein is a multifunctional enzyme in DNA replication, Strand breakage by DNA untwisting enzyme results in covalent 3198 attachment of enzyme to DNA, 3800 Strand breakage by DNA untwisting enzyme results in covalent Deoxyribonucleic acid, viral attachment of enzyme to DNA, 3800 2-Aminopurine-induced mutagenesis in T4 bacteriophage: Model relating Synthesis of 4X174 viral DNA in vitro depends on OX replicative form mutation frequency to 2-aminopurine incorporation in DNA, 4806 I)NA, 4195 Assembly of biologically active proheads of bacteriophage lambda in Terminus region of chromosome in Escherichia coli inhibits replication vitro, 906 forks, 3927 Association of e antigen with Dane particle DNA in sera from Deoxyribonucleic acid, replicative form asymptomatic carriers of hepatitis B surface antigen, 2149 Bidirection replication from a unique origin in a mini-F plasmid, 1138 Cleavage map of linear mouse sarcoma virus DNA, 29 Discontinuous replication of replicative form DNA from bacteriophage DNA packaging and pathway of bacteriophage T4 head assembly, 3652 (/)X174, 2776 DNA sequencing with chain-terminating inhibitors, 5463 Deoxyribonucleic acid, ribosomal Electron microscope studies of transient complexes formed between Cloned segment of Drosophila melanogaster rDNA containing new types Escherichia coli RNA polymerase holoenzyme and T7 DNA, 3740 of sequence insertion, 4932 Epstein-Barr viral DNAs compared in Burkitt lymphoma biopsy cells Simple Mendelian inheritance of reiterated ribosomal DNA of yeast, and in cells clonally transformed in vitro, 4651 5091 Gene for thymidine kinase transferred to thymidine kinase-deficient Sites of transcription initiation in vivo on Xenopus laevis ribosomal human cells by purified herpes simplex viral DNA, 1590 I)NA, 5402 Infectious DNA of spleen necrosis virus is integrated at a single site in Deoxyribonucleic acid, satellite DNA of chronically infected chicken fibroblasts, 281 lIimited accessibility of chromatin satellite DNA to RNA polymerase Integration of avian sarcoma virus DNA sequences in transformed from Escherichia coli, 4'337 mammalian cells, 4301 Deoxyribonucleic acid sequence Loop structures in hybrids of early RNA and separated strands of see also Nucleotide sequence adenovirus DNA, 4392 I)NA sequence organization in water mold Achlya, 4332 Mapping of closed circular DNAs by cleavage with restriction Gene-sized DNA molecules of Oxytricha macronucleus have the same endonucleases and calibration by agarose gel electrophoresis, 851 terminal sequence, 4325 Mapping of inverted repeated I)NA sequences within genome of simian Mapping of sequences with 2-fold symmetry on simian virus 40 genome: virus 40, 1631 Photochemical crosslinking approach, 1363 Mapping of sequences with 2-fold symmetry on simian virus 40 genome: Method for sequencing DNA, 560 Photochemical crosslinking approach, 1363 Minimal length of lactose operator sequence for specific recognition by Mechanism of duplex DNA replication revealed by enzymatic studies of lactose repressor, 966 phage (/X174: Catalytic strand separation in advance of replication, Nucleotide sequence of operator-promoter region of galactose operon of 193 Escherichia coli, 106 Mechanism of phage (AX174DNA inactivation by Physical mapping of a DNA sequence common to plasmids of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, 3335 incompatibility group F 1, 1190 Naturally occurring crosslinks in vaccinia virus DNA eliminated after Rous sarcoma virus genome is terminally redundant: The 5' sequence, viral penetration into cells, 1739 989 Site-specific single-strand endonuclease from the eukaryote Rots sarcoma virus genome is terminally redundant: The 3' sequence, Chlamydomonas, 2687 994 State of prophage Mu DNA upon induction, 3143 Sequence relationship between long and short repetitive DNA of the rat, Structure of a large segment of genome of simian virus 40 that does not 4382 encode known proteins, 827 Thermostable sequence-specific endonuclease from Thermus aquaticus, Structure of a large segment of genome of simian virus 40 that does 542 not encode known proteins (correction), 2594 Deoxyribonucleic acid, single-stranded Supercoiled circular DNA of insect granulosis virus, 3574 Renaturation of complementary single-stranded DNA circles: Complete Type 5 adenovirus DNA persists in cells transformed by a rewinding facilitated by DNA untwisting enzyme, 5328 temperature-sensitive mutant, H5ts 125, 785 Single-stranded DNA from oncornavirus-infected cells enriched in Deoxyribonucleic acid, yeast virus-specific DNA sequences, 3720 Nucleotide sequence of mutant eukaryotic gene: Yeast tyrosine-inserting Deoxyribonucleic acid structure ochre suppressor SUP4-o, 5453 see also Polynucleotide structure Deoxyuridine, bromo- Elastic model of supercoiling, 2397 In vivo analysis of cellular replication, 2041 Nucleotide seqtiences near origin of replication of bacteriophage fl, 4219 Deoxyuridine, fluoro- Deoxyribonucleic acid supercoiling Perturbation of chloroplast DNA amounts and chloroplast gene Histone H3 disulfide dimers and nucleosome structure, 5519 transmission in Chlamydomonas reinhardtii by 5-fluorodeoxytridine, Deoxyribonucleic acid synthesis 4552 Antipain and leupeptin restrict uterine DNA synthesis and function in Deoxyuridine, iodo- mice, 3754 Transient induction of nuclear antigen unrelated to Epstein-Barr 2'-I)eoxy-2'-azidocytidine inhibits initiation of polyoma DNA synthesis, nuclear antigen in cells of two human B-lymphoma lines converted by 5310) Epstein-Barr virus, 363 l)issociation of tumor promoter-stimulated ornithine decarboxylase Deoxyuridinetriphosphatase (EC 3.6.1.23) activity and DNA synthesis in mouse epidermis in vivo and in vitro by Transient accumulation of Okazaki fragments as a result of uracil fluocinolone acetonide, a tumor-promotion inhibitor, 3908 incorporation into nascent DNA, 154 I)ivision of BALB/c mouse 3'T'3and simian virus 40-transformed 3T3 Depolarization method cells in cellular aggregates, 3874 Rotational relaxation of 70S ribosomes by a depolarization method using I)NA or RNA priming of bacteriophage G4 DNA synthesis by triplet probes, 1407 Escherichia coli dnaG protein, 2815 Desmin I)NA packaging and pathway of bacteriophage T4 head assembly, 3652 Major structural and regulatory proteins of chick muscle cells: Invariance I)NA synthesis induced in BALB/c 3T3 cells by serum components: and heterogeneity revealed by two-dimensional gel electrophoresis, Reevaluation of commitment process, 4481 1450 Enzymatic initiation of DNA synthesis by yeast DNA polymerases, 1937 Detergent Fibroblast heterogeneity and prostaglandin regulation of subpopulations, see also Triton X-100 :3429 Charge shift electrophoresis: Method for distinguishing between Histone and DNA synthesis: Noncoincidence in cleavage cycles of early amphiphilic and hydrophilic proteins in detergent solution, 529 development, 5016 Molecular weight and valence of cell-surface receptor for Histones: Metabolism in simian virus 40-infected cells and incorporation immunoglobulin E, 869 into virions, 2805 Downloaded by guest on September 27, 2021 Proc. 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Deuteriummagnetic resonance Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: Deuterium magnetic resonance studies of interaction of lipids with Increased transcription during erythroid differentiation, 2475 membrane proteins, 5435 Hemoglobin F synthesis in vitro: Control at level of primitive erythroid Developmentalbiology stem cells, 2923 High-fidelity transcription of 5S DNA injected into Xenopus oocytes, Hexamethylene bisacetamide induces morphologic changes and increased 2064 synthesis of procollagen in cell line from glioblastoma multiforme, Dexamethasone 5060 Genetic dissection of control of normal differentiation in myeloid Hormonal effects on intracellular and secreted casein in cultures of leukemic cells, 5554 mouse mammary epithelial cells on floating collagen membranes, 4466 Glucocorticoids increase responsiveness of cells in culture to Independent expression of adrenergic phenotype by neural crest cells in prostaglandin El, 4816 vitro, 2899 Increased dexamethasone resistance of cystic fibrosis fibroblasts, 5642 Independent expression of adrenergic phenotype by neural crest cells in Pregrowth hormone messenger RNA: Glucocorticoid induction and uitro (correction), 4706 identification in rat pituitary cells, 2357 Inhibition of cytokinesis in Friend leukemia cells by membrane mobility Dextran agents, 2884 Luminal membrane retrieved after exocytosis reaches most Golgi Inhibition of transcription and translation of globin messenger RNA in cisternae in secretory cells, 5073 dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated Diabetes with interferon, 2036 Glucose homeostasis during prolonged suppression of glucagon and Loss of growth control and differentiation in fu-1 variant of L8 line of rat insulin secretion by somatostatin, 348 myoblasts, 3888 Neurophysin biosynthesis in normal rats and in rats with hereditary Low-molecular-weight peptide inhibits RNA synthesis in human diabetes insipidus, 4046 leukemic and phytohemagglutinin-stimulated leukocytes and globin Serum sex hormones and glucose, insulin, and lipid abnormalities in men mRNA transcription in differentiating Friend cells, 3869 with myocardial infarction, 1729 Morphological differentiation of neuroblastoma cells in medium Streptozotocin-induced insulitis and diabetes, 2485 supplemented with delipidated serum, 3893 Diadenosinepentaphosphate Mutational analysis of developmental control in Caulobacter crescentus, Asymmetric binding of the inhibitor di(adenosine-5')pentaphosphate 124 (Ap5A) to adenylate kinase, 5355 Plasma membrane proteins: Changes in composition during Diazepam differentiation of embryonic chick erythroid cell, 1062 Mechanisms by which diazepam, muscimol, and other drugs change the Proliferative and plaque-forming cell responses inhibited by human content of cGMP in cerebellar cortex, 3592 bone-marrow-derived lymphocytes from peripheral blood by antisera Specific benzodiazepine receptors in rat brain characterized by to p23,30 antigen, 711 high-affinity [3H]diazepam binding, 3805 Sequential stages of human T lymphocyte differentiation, 3414 5,6-Dichloro-l-fl-D-ribofuranosylbenzimidazole Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit Nucleoplasmic RNA: Definition of subclasses, 5011 synthesis of brain-specific protein in rat glial cells, 3855 Dictyosteliumdiscoideum Surface antigen in early differentiation, 4449 Calcium control of actin-activated myosin adenosine triphosphatase from Thymic activity in severe combined immunodeficiency diseases, 1250 Dictyostelium discoideum (correction), 392 Thymopoietin and thymic hormone levels in human plasma: Bioassay Cell differentiation in Dictyostelium under submerged conditions, 268 determinations, 2541 3':5'-Cyclic AMP-dependent 3':5'-cyclic GMP accumulation in Thymosin CYi:Isolation and sequence analysis of immunologically active Dictyostelium discoideum, 2348 thymic polypeptide, 725 Defined minimal medium for axenic strains of Dictyostelium Transient inhibition of initiation of S-phase associated with discoideum, 2157 dimethylsulfoxide induction of murine erythroleukemia cells to Thermotaxis by pseudoplasmodia of Dictyostelium discoideum, 2007 erythroid differentiation, 248 Unified mechanism for relay and oscillation of cyclic AMP in Transitions in collagen types during matrix-induced cartilage, bone, and Dictyostelium discoideum, 1543 bone marrow formation, 5589 Dicyclohexylcarbodiimide Tumor promoters inhibit spontaneous differentiation of Friend Isolation of chloroplast N,N'-dicyclohexylcarbodiimide-binding erythroleukemia cells in culture, 2894 proteolipid, active in proton translocation, 2375 Tumor promoters inhibit spontaneous and induced differentiation of 31p nuclear magnetic resonance measurements of ATPase kinetics in murine erythroleukemia cells in culture, 3451 aerobic Escherichia coli cells, 5551 Unified mechanism for relay and oscillation of cyclic AMP in Dielectric relaxation Dictyostelium discoideum, 1543 Kinetic polarization deficiency in electrolyte solutions, 401 Differentiation, placental Diet Human placental lactogen mRNA and its structural genes during see also Nutrition pregnancy: Quantitation with complementary DNA, 1024 Carcass components at first estrus of rats on high-fat and low-fat diets: Diffraction Body water, protein, and fat, 379 General variational principles applicable to the hybrid element method, Diethylstilbestrol 2595 Sex-limited serum protein of Syrian hamsters: Definition of female Diffusion protein and regulation by testosterone, 730 Kinetic and electrochemical memory in enzyme membranes, 5314 Differentiation Digitonin Differentiation of integrals, 2211 Adenylate cyclase-free, /-adrenergic receptor isolated from turkey Interaction of different egg parts in determination of various body erythrocyte membranes by affinity chromatography, 3710 regions in Drosophila melanogaster, 2050 Dihydroalprenolol Differentiation,cell Induction of functional /-adrenergic receptors in HeLa cells, 873 Alterations in insulin binding accompanying differentiation of 3T3-L1 Dihydroergocryptine preadipocytes, 4876 Brain dopamine receptors: Detection with [3H]dihydroergocryptine, 3750 Anionic glycopeptides and glycosaminoglycans synthesized by embryonic 1,5-Dihydroflavin, N5-alkyl- neural tube and neural crest, 1057 Chemiluminescent reactions and electrophilic oxygen donating ability of Anionic glycopeptides and glycosaminoglycans synthesized by embryonic 4a-hydroperoxyflavins: Preparation of N5-alkyl-1,5-dihydroflavins, 405 neural tube and neural crest (correction), 4076 Dihydrofolate reductase Cell differentiation in Dictyostelium under submerged conditions, 268 see Tetrahydrofolate dehydrogenase Chromosome mapping of genes that control differentiation and Dihydrotestosterone malignancy in myeloid leukemic cells, 253 9S binding protein for androgens and progesterone, 1960 Combined use of fetal liver and thymus for immunological reconstitution Dimethylsuberimidate in patients with variants of severe combined immunodeficiency, 3002 Crosslinked histone octamer as model of nucleosome core, 2780 Control of development: Isolation of Bacillus subtilis mutants blocked Crosslinked histone octamer as model of nucleosome core (correction), early in sporulation and defective in synthesis of highly 5198 phosphorylated nucleotides, 1125 Dimeric immunoglobulin E serves as unit signal for mast cell Development of electrophysiological and biochemical membrane degranulation, 2993 properties during differentiation of embryonic skeletal muscle in Dimethyl sulfate culture, 5166 Method for sequencing DNA, 560 Differential effects of chemical inducers on expression of ,/ globin genes Dimethyl sulfoxide in murine erythroleukemia cells, 1100 Chromatin protein appears during erythroid differentiation of Friend DNA degradation in terminally differentiating lens fiber cells from chick virus-transformed cells, 653 embryos, 5579 Chromatin protein appears during erythroid differentiation of Friend Embryonic chicken brain and mouse neuroblastoma cells NIE-115 and virus-transformed cells (correction), 3104 N-18 contain an inhibitor of acid deoxyribonuclease, 842 Inhibition of transcription and translation of globin messenger RNA in Endotoxin-induced serum factor controlling differentiation of dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated bone-marrow-derived lymphocytes, 1200 with interferon, 2036 Expression of Ia-like antigen molecules on human granulocytes during Inside-out model for self-assembly of tobacco mosaic virus, 149 early phases of differentiation, 4012 Transient inhibition of initiation of S-phase associated with Extracellular inducer of asexual plasmodium formation in Physarum dimethylsulfoxide induction of murine erythroleukemia cells to polycephalum, 1120 erythroid differentiation, 248 Gene activation in somatic nuclei after injection into amphibian oocytes, 2,4-Dinitrophenyl- 2470 Multispecific lymphoid cell surface receptors, 1224 Genetic dissection of control of normal differentiation in myeloid Diphenylhydantoin leukemic cells, 5554 Ethylphenacemide and phenacemide: Conformational similarities to Downloaded by guest on September 27, 2021 5804 Subject Index Proc. 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diphenylhydantoin and stereochemical basis of anticonvulsant activity, Drug resistance 1264 Selective amplification of genes on the R plasmid, NR1, in Proteus 2,3-Diphosphoglycerate mirabilis: Example of induction of selective gene amplification, 2518 Native human hemoglobin reconstituted from separated globin chains Drug resistance factor RP4 and alloplex intermediates, 64 Genetic mapping of Rhizobium meliloti, 2076 Dipicolinic acid D-type virus Biological function of gramicidin: Gramicidin-negative mutants, 780 Endogenous new world primate retrovirus: Interspecies antigenic Diplococcus pneumoniae determinants shared with major structural protein of type-D RNA Inhibitors of genetic recombination in pneumococci, 296 viruses of old world monkeys, 5734 Disease incidence Evolution of primate oncornaviruses: Endogenous virus from langurs Nonidentifiability in stochastic models of illness and death, 1338 (Presbytis spp.) with related virogene sequences in other Old World Diurnal rhythm monkeys, 4557 Thyrotropin-releasing hormone-like material in rat retina: Changes due Interspecies radioimmunoassay for major structural proteins of primate to environmental lighting, 3579 type-D retroviruses, 5739 Domain, pseudo-convex Duality gap Sufficient conditions for subellipticity on weakly pseudo-convex Convex programs having some linear constraints, 26 domains, 2214 Dye L-Dopa Food, drug, and cosmetic dyes: Biological effects related to lipid Dopamine-dependent adenylate cyclase: Quantitative correlation with solubility, 2914 responses to levodopa in various mice, 1242 Interaction of tetraiodofluorescein with a modified form of aspartate L-3,4-Dihydroxyphenylalanine-induced hypersensitivity simulating transcarbamylase, 111 features of denervation, 2126 Mechanism of oxidation of tryptophan to formylkynurenine-25 years Dopa decarboxylase .later, 4730 see Aromatic L-amino-acid decarboxylase Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in D)opamine liposomes, 1580 Adenylate cyclase from synchronized neuroblastoma cells: Mutagen-nucleic acid intercalative binding: Structure of Responsiveness to prostaglandin El, adenosine, and dopamine during 9-aminoacridine-5-iodocytidylyl(3'-5')guanosine crystalline complex, cell cycle, 1575 188 Brain dopamine receptors: Detection with [3H]dihydroergocryptine, 3750 Nonintercalative binding of ethidium bromide to nucleic acids: Crystal Conformational requirements for dopamine-induced vasodilation, 3602 structure of ethidium-tRNA molecular complex, 4821 Dopamine-dependent adenylate cyclase: Quantitative correlation with Sensory electrophysiology of bacteria: Relationship of membrane responses to levodopa in various mice, 1242 potential to motility and chemotaxis in Bacillus subtilis, 4752 Dopaminergic stimulation of cyclic AMP accumulation and parathyroid Dynein hormone release from dispersed bovine parathyroid cells, 4210 Dynein identified as outer arms of sea urchin sperm axonemes, 5006 Explant cultures of catecholamine-containing neurons from rat brain: Dyskinesia Biochemical, histofluorescence, and electron microscopic studies, 4471 L-3,4-Dihydroxyphenylalanine-induced hypersensitivity simulating Opposing effects of dopaminergic to cholinergic compounds on cerebral features of denervation, 2126 dopamine-activated adenylate cyclase, 769 Dopamine f-monooxygenase (EC 1.14.17.1) Somatostatin-like immunoreactivity occurs in some peripheral sympathetic noradrenergic neurons, 3587 Ear Double helix Carbonic anhydrase from the inner ear of guinea pig: Purification, 892 Spatial configuration of ordered polynucleotide chains: A novel double Earthquake helix, 1775 General variational principles applicable to the hybrid element method, Drosophila 2595 Gene regulation in Drosophila mulleri, D. arizonensis, and their hybrids: Theory of connectivity for formally symmetric operators, 4722 Nucleolar organizer, 3498 Earth's core Microcomplement fixation studies on evolution of a-glycerophosphate Transient magnetic effects in scale model of earth's core, 4744 dehydrogenase within genus Drosophila, 684 Ecdysone Drosophila melanogaster 3':5'-Cyclic AMP and hormonal control of puparium formation in fleshfly Adaptive response due to changes in gene regulation: Study with Sarcophaga bullata, 2182 Drosophila, 4562, Ecdysone: Roles in Drosophila development, 5099 Cloned segment of Drosophila melanogaster rDNA containing new types Role of ecdysone, pupariation factors, and cyclic AMP in formation and of sequence insertion, 4932 tanning of puparium of fleshfly Sarcophaga bullata, 4697 Ecdysone: Roles in Drosophila development, 5099 Secretion of os-ecdysone by crab Y-organs in vitro, 615 Genetic instability in Drosophila melanogaster: Putative multiple Ecology insertion mutants at singed bristle locus, 2973 Colony-specific territorial pheromone in African weaver ant Oecophylla Genetic instability in Drosophila melanogaster: De novo induction of longinoda (Latreille), 2072 putative insertion mutations, 3490 Current-induced flow through living sponges in nature, 2069 Interaction of different egg parts in determination of various body Food webs and dimensionality of trophic niche space, 4533 regions in Drosophila melanogaster, 2050 Economics Localization of RNA polymerase in polytene chromosomes of Drosophila Structure of production sets with indivisibilities, 3637 melanogaster, 2079 Edman degradation Mechanism of genetic coadaptation in populations of Drosophila Human platelet factor 4: Amino acid sequence, 2256 melanogaster, 324 Egg Sequences homologous to ribosomal insertions occur in Drosophila see also Oocyte genome outside the nucleolus organizer, 4233 Egg, fish Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, Free calcium increases explosively in activating medaka eggs, 623 2514 Eggshell, avian Translation of Drosophila melanogaster sequences in Escherichia coli, Reduction of pore area of avian eggshell as adaptation to altitude, 3095 5041 8,11,14-Eicosatrienoic acid Drosophila mojavensis Inhibition of prostaglandin endoperoxide synthetase by thiol analogues Extension of longevity in Drosophila mojavensis by environmental of prostaglandin, 144 ethanol: Differences between subraces, 387 Novel prostaglandin is major product of arachidonic acid metabolism in Drought rabbit heart, 101 Weather modification technology: Statistician's view (Review), 4714 Elasticity Drug, antimicrotubular Elastic model of supercoiling, 2397 Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit General variational principles applicable to the hybrid element method, synthesis of brain-specific protein in rat glial cells, 3855 2595 Drug binding Theory of connectivity for formally symmetric operators, 4722 Addition of colchicine-tubulin complex to microtubule ends: Mechanism Electret of substoichiometric colchicine poisoning, 3466 Electromagnetism and gravitation, 2664 Drug-delivery system Electric eel Lipid vesicles in vivo: Gamma-ray perturbed angular correlation study, see Electrophorus electricus 4991 Electric field Drug intercalation Hemolysis of human erythrocytes by transient electric field, 1923 Inhibitors of genetic recombination in pneumococci, 296 -Electroencephalogram Mutagen-nucleic acid intercalative binding: Structure of Delta-electroencephalogram(-sleep)-inducing peptide: Characterization, 9-aminoacridine.5-iodocytidylyl(3'-5')guanosine crystalline complex, 1282 188 Electrolyte solution Netropsin-poly(dA-dT) complex in solution: Structure and dynamics of Kinetic polarization deficiency in electrolyte solutions, 401 antibiotic-free base pair regions and those centered on bound Electromagnetism netropsin, 5207 Electromagnetism and gravitation, 2664 Drug, microtubule-destroying Electron, Ir Antitubulins affect redistribution of crosslinked receptors on surface of Mathematical description of molecular structure: Molecular topology, fibroblasts and epithelial cells, 2865 2616 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Electronacceptor Blue copper proteins: Synthesis, spectra, and structures, of CuIN3(SR) Electronic properties of casein-methylglyoxal complex, 226 and CuIIN3(SR) active site analogues, 3114 Living state and cancer, 2844 Coupling in cytochrome c oxidase, 3662 Electron affinity Electronically excited retinal, 3375 Electron affinity of methyl radical: Structures of CH3 and CH3-, 410 Electron transfer: Experimental verification of vibronically coupled Electronflow electron tunneling, 3817 Uncouplers and molecular mechanism of uncoupling in mitochondria, Oxygen intermediates and mixed valence states of cytochrome oxidase: 2241 Infrared absorption difference spectra of compounds A, B, and C of Electronicstate cytochrome oxidase and oxygen, 4777 Magnetic properties of oxyhemoglobin, 398 Oxygen "pulsed" cytochrome c oxidase: Functional properties and Electronmicroscopy catalytic relevance, 3128 Actin-like protein extracted from prokaryote Mycoplasma pneumoniae, Vibronically coupled tunneling description of biological electron transfer: 4041 Experimental test, 229 Arrangement of subunits in assembled histone H4 fibers, 3772 Electrophilic oxygen donation Bidirection replication from a unique origin in a mini-F plasmid, 1138 Chemiluminescent reactions and electrophilic oxygen donating ability of C-reactive protein and complement subcomponent Clt characterized as 4a-hydroperoxyflavins: Preparation of N5-alkyl-1,5-dihydroflavins, 405 homologous proteins diplaying cyclic pentameric symmetry Electrophoresis (pentraxins), 739 Analysis of single- and double-stranded nucleic acids on polyacrylamide 2'-Deoxy-2'-azidocytidine inhibits initiation of polyoma DNA synthesis, and agarose gels by using glyoxal and acridine orange, 4835 5310 Antigenic distinctions of glycoproteins in plasma and mitochondrial Direction of active sliding of microtubules in Tetrahymena cilia, 2045 membranes of lymphoid cells neoplastically transformed by simian Electron microscope studies of transient complexes formed between virus 40, 643 Escherichia coli RNA polymerase holoenzyme and T7 DNA, 3740 Charge shift electrophoresis: Method for distinguishing between Electron microscopy of fibers and discs of hemoglobin S having sixfold amphiphilic and hydrophilic proteins in detergent solution, 529 symmetry, 5538 Cleavage map of linear mouse sarcoma virus DNA, 29 Electron microscopy of negatively stained and freeze-etched high density Comparative subunit structure of HeLa, yeast, and chicken erythrocyte lipoprotein-3 from human serum, 5001 chromatin, 79 Inside-out model for self-assembly of tobacco mosaic virus, 149 Human plasma proteins: High resolution two-dimensional Isolation and preliminary characterization of 10-nm filaments from baby electrophoresis, 5421 hamster kidney (BHK-21) cells, 2422 3-Hydroxy-3-methylglutaryl-coenzyme A reductase purified from rat Mapping of inverted repeated DNA sequences within genome of simian liver, 1431 virus 40, 1631 Major structural and regulatory proteins of chick muscle cells: Invariance Mapping of sequences with 2-fold symmetry on simian virus 40 genome: and heterogeneity revealed by two-dimensional gel electrophoresis, Photochemical crosslinking approach, 1363 1450 Mapping of transcription sites of simian virus 40-specific late 16S and Mapping of closed circular DNAs by cleavage with restriction 19S mRNA by electron microscopy, 496 endonucleases and calibration by agarose gel electrophoresis, 851 Method for localizing proteins in periodic structures: Fab fragment Polyploidy affects phosphoglucose isomerase diversity in Festuca labeling combined with image processing of electron micrographs, 5514 microstachys, 1652 Polylysine used for adsorption of nucleic acids and enzymes to electron Virion polypeptides identified in hamster cells transformed by herpes microscope specimen films, 2311 simplex virus type 1, 372 Polypeptide hormone binding sites in vivo: Initial localization of Electrophorus electricus 125I-labeled insulin to hepatocyte plasmalemma visualized by electron Batrachotoxin affects electroplax of electric eel: Voltage-dependent microscope radioautography, 5051 interaction with sodium channels, 951 Protein structure of probable membrane derivation associated with Functional acetylcholine receptor-electroplax membrane microsacs HeLa cell mitochondrial DNA near its origin of replication, 1348 (vesicles): Purification and characterization, 482 Reconstitution of tobacco mosaic virus rods occurs bidirectionally from Electroplax an internal initiation region: Demonstration by electron microscopic see also Membrane, electroplax serology, 1913 Batrachotoxin affects electroplax of electric eel: Voltage-dependent Ribosome structure: Localization of N6,N6-dimethyladenosine by interaction with sodium channels, 951 electron microscopy of a ribosome-antibody complex, 1468 Perhydrohistrionicotoxin: Potential ligand for ion conductance Sequence arrangement of 5' ends of simian virus 40 16S and 19S modulator of acetylcholine receptor, 2172 mRNAs, 4982 Elliptic integral Spliced segments at 5' terminus of adenovirus 2 late mRNA, 3171 Extended Watson integrals for cubic lattices, 1800 Structure of histone HI-DNA complex: Effect of histone Hi on DNA Elongation factor condensation, 4852 Conformational alteration of protein synthesis elongation factor EF-Tu Supercoiled circular DNA of insect granulosis virus, 3574 by EF-Ts and by kirromycin, 3264 Ultrastructural localization of cell membrane GM1ganglioside by cholera Elongation factor Tu resistant to kirromycin in Escherichia coli mutant toxin, 3782 altered in both tuf genes, 4341 Electron microscopy, freeze-fracture Escherichia coli mutant with temperature sensitive function affecting Glycophorin and the concanavalin A receptor of human erythrocytes: bacteriophage Q,/ RNA replication, 1657 Receptor function in lipid bilayers, 2751 Isomeric aminoacyl-tRNAs are both bound by elongation factor Tu, 437 Lipid and protein segregation in Escherichia coli membrane: mRNA-dependent in vitro synthesis of ribosomal proteins L12 and L10O Morphological and structural study of different cytoplasmic membrane and elongation factor Tu, 5387 fractions, 452 Proofreading of codon-anticodon interaction on ribosomes, 198 Electron microscopy, scanning Embryo, chick Ligand-independent cap formation: Redistribution of surface receptors Calcium-binding protein of chorioallantoic membrane: Identification and on mouse lymphocytes and thymocytes in hypertonic medium, 4511 developmental expression, 1946 Electron microscopy, scanning transmission Do myoblasts in vivo withdraw from the cell cycle? 2031 Direct observations of atomic diffusion by scanning transmission Embryogenesis electron microscopy, 1802 Interaction of different egg parts in determination of various body Electron paramagnetic resonance regions in Drosophila melanogaster, 2050 Blue copper proteins: Synthesis, spectra, and structures, of CuIN3(SR) Oligouridylate stretches in heterogeneous nuclear RNA, 2217 and CulIN3(SR) active site analogues, 3114 Tadpole and adult globin RNA sequences in oocytes of Xenopus laevis, Electron paramagnetic resonance studies of photosynthetic electron 3835 transport: Photoreduction of ferredoxin and membrane-bound Embryology iron-sulfur centers, 3826 Embryologic development of mouse sympathetic ganglion in vivo and in Membrane-controlled depletion of complement activity by vitro, 3438 spin-label-specific IgM, 3537 Embryonic corneal epithelium Electron scattering Synthesis of two collagen types of embryonic chick corneal epithelium in Structure determination of gaseous and amorphous substances, by vitro, 39 diffraction methods: Philosophical concepts and their implementation Emission Mossbauer spectrum (Review), 4707 Stereochemical trigger that initiates cooperative interaction of Electron spin resonance hemoglobin subunits: Emission Moo;sbauer study, 4996 13C nuclear magnetic resonance studies of radiation damage: Emphysema Radiation-induced degradation of glycine, 2394 Specific lysine labeling by lOH- during alkaline cleavage of Differential lateral mobility of IgM and IgG receptors in mouse B ae-l-antitrypsin-trypsin complex, 4311 lymphocyte membranes, 4595 Endocytosis Electronic properties of casein-methylglyoxal complex, 226 Binding and internalization of thrombin by normal and transformed Electron spin resonance absorption of tissue constituents, 1558 chick cells, 596 Lipid-protein interaction in phosphatidylcholine exchange protein, 1807 Endocytosis: Response to altered fatty acyl composition of macrophage Nuclear coupling of 33S and nature of free radicals in irradiated crystals phospholipids, 4895 of N-acetyl-L-cysteine, 216 Endodeoxyribonuclease Sendai virus-induced hemolysis: Reduction in heterogeneity of Cloning of silk fibroin gene and its flanking sequences, 5363 erythrocyte lipid bilayer fluidity, 1918 Endonuclease Synthesis and characterization of "face-to-face" porphyrins, 18 see also Endoribonuclease III; Restriction endonuclease; Staphylococcal Electrontransfer nuclease see also Transport, electron Different rate-limiting steps in excision repair of ultraviolet- and Downloaded by guest on September 27, 2021 5806 SubjectIndex Proc. 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N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human Regional dissociation of /-endorphin and enkephalin contents in rat fibroblasts, 1548 brain and pituitary, 5162 Naturally occurring crosslinks in vaccinia virus DNA eliminated after Enoyl-CoA hydratase (EC 4.2.1.17) viral penetration into cells, 1739 Multi-enzyme complex of fatty acid oxidation isolated from Escherichia Release of Escherichia coli DNA from membrane complexes by coli, 492 single-strand endonucleases, 2756 Enthalpy, van't Hoff Site-specific single-strand endonuclease from the eukaryote Disagreement between calorimetric and van't Hoff enthalpies of Chlamydomonas, 2687 assembly of protein supramolecular structures, 2002 Specific action of T4 endonuclease V on damaged DNA in xeroderma Entrainment pigmentosum cells in vivo, 2958 Mutual entrainment of bilaterally distributed circadian pacemakers, Endoperoxide 1277 Imidazole: Selective inhibitor of thromboxane synthetase in human Entropy platelets, 1716 Heat capacity and entropy changes in processes involving proteins, 2236 Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin Living state and cancer, 2844 methyl ester: Comparison with endoperoxides and other prostanoids, Measures of fitness and demographic stability, 384 5711 Microscopic theory of irreversible processes, 4152 Endoplasmic reticulum Enucleation N-Acetylglucosamine incorporated into endogenous acceptors of rough Cells reconstituted from cell fragments of two different species multiply microsomes from rat liver: Stimulation by GTP after treatment with and form colonies, 606 pyrophosphate, 1095 Enucleation and reconstruction of interferon-producing cells, 3391 Endoribonuclease III Selection of reconstituted cells from karyoplasts fused to see also Endonuclease chloramphenicol-resistant cytoplasts, 2461 Endoribonuclease III (EC 3.1.4.24) Environmental heterogeneity Nucleotide sequence from a ribonuclease III processing site in Extension of longevity in Drosophila mojavensis by environmental bacteriophage T7 RNA, 822 ethanol: Differences between subraces, 387 Nucleotide sequence surrounding a ribonuclease III processing site in Enzyme bacteriophage T7 RNA, 984 see also Cryoenzymology; Multienzyme complex Endorphin Enzyme activation see also Enkephalin Cleavage of C2 by Cls into antigenically distinct fragments C2a and C2b: Common precursor to corticotropins and endorphins, 3014 Binding of C2b to C4b, 2998 Effects of naloxone on experimentally induced ischemic pain and on Interaction of tetraiodofluorescein with a modified form of aspartate mood in human subjects, 1291 transcarbamylase, 111 /1-Endorphin: In vitro biosynthesis in pituitary glands, 1403 Enzyme activity /-Lipotropin: Localization of cells and axons in rat brain by Binding of Zn2+ to rat liver fructose-1,6-bisphosphatase and its effect on immunocytochemistry, 5155 catalytic properties, 2742 Neuronal actions of endorphins and enkephalins among brain regions: Enzyme, allosteric Comparative microiontophoretic study, 2584 Ligand-promoted weakening of intersubunit bonding domains in Opiate peptides synthesized by a clonal pituitary tumor cell line, 2259 aspartate transcarbamoylase, 3777 ~f-Endorphin Enzyme binding site Conformation of /-endorphin and /-lipotropin: Formation of helical Analytical and graphical examination of strong binding by half-of-sites structure in methanol and sodium dodecyl sulfate solutions, 3235 in proteins: Illustration with aspartate transcarbamylase, 4959 /-Endorphin: Behavioral and analgesic activity in cats, 774 Enzyme catalysis /-Endorphin: Development of tolerance and its reversal by see also Catalysis 5-hydroxytryptophan in cats, 4017 Ionic regulation in genetic translation systems, 1013 /-Endorphin: Pituitary and adrenal glands modulate its action, 4628 Enzyme cleft /-Endorphin: Stimulation of growth hormone release in vivo, 358 Homology among acid proteases: Comparison of crystal structures at 3A In vitro biosynthesis of /-endorphin, -y-lipotropin, and /-lipotropin by resolution of acid proteases from Rhizopus chinensis and Endothia pars intermedia of beef pituitary glands, 4276 parasitica, 556 Isolation and characterization of opioid peptides from rat pituitary: Enzyme-enzyme interactions /-Endorphin, 4969 Theoretical study of effect of enzyme-enzyme interactions on Regional dissociation of /-endorphin and enkephalin contents in rat steady-state enzyme kinetics, 3632 brain and pituitary, 5162 "Virial" expansion of enzyme flux and use of quasi-chemical Endosperm approximation for two-state enzymes with enzyme-enzyme Controlling element-induced alterations in UDPglucose:flavonoid interactions, 5227 glucosyltransferase, the enzyme specified by bronze locus in maize, Enzyme, hybrid 5623 Polyploidy affects phosphoglucose isomerase diversity in Festuca Endothelium microstachys, 1652 Regenerated endothelium affects lipid accumulation in arterial wall, 1724 Enzyme, immobilized Endothia parasitica Dissociation and reassociation of immobilized porphobilinogen synthase: Homology among acid proteases: Comparison of crystal structures at 3A Use of immobilized subunits for enzyme isolation, 1383 resolution of acid proteases from Rhizopus chinensis and Endothia Enzyme induction parasitica, 556 Enzyme regulation in neuroblastoma cells in a salts/glucose medium: Endotoxin Induction of ornithine decarboxylase by asparagine and glutamine, Endotoxin-induced serum factor controlling differentiation of 3791 bone-marrow-derived lymphocytes, 1200 Nerve growth factor increases activity of ornithine decarboxylase in Prostaglandin regulation of macrophage collagenase production, 4955 superior cervical ganglia of young rats, 4681 Energy Pineal protein phosphorylation during serotonin N-acetyltransferase see also Conformational energy induction, 1928 Molecular events and energy changes during action potential, 3810 Uterine peroxidase as marker for estrogen action, 3162 Energy, activation Enzyme isolation Endocytosis: Response to altered fatty acyl composition of macrophage Dissociation and reassociation of immobilized porphobilinogen synthase: phospholipids, 4895 Use of immobilized subunits for enzyme isolation, 1383 Energy coupling Enzyme kinetics Kinetic proofreading in aminoacylation of tRNA by synthetase, 2246 see also Kinetics Reconstitution of thermostable ATPase capable of energy coupling from Adenylate kinase: 31P nuclear magnetic resonance kinetic measurements, its purified subunits, 936 3627 Energy transfer Enzyme-enzyme interactions affect steady-state enzyme kinetics, 4111 Light collection and harvesting processes in bacterial photosynthesis Human erythrocyte pyrimidine 5'-nucleotidase: Purification and investigated on picosecond time scale, 1997 properties, 3701 Tripartite model for photochemical apparatus of green plant Kinetic and electrochemical memory in enzyme membranes, 5314 photosynthesis, 3382 Kinetic evidence for an intermediate in deacetylation of Enkephalin monoacetyl-chymotrypsin, 510 see also Endorphin; /-Endorphin Mechanism of phosphorylation of synthetic polypeptides by calf thymus Biologically active conformation of opiates and enkephalin, 5179 cyclic AMP-dependent protein kinase, 4261 Effects of naloxone on experimentally induced ischemic pain and on Monomeric form of pyruvate kinase in human pyruvate kinase mood in human subjects, 1291 deficiency, 501 /-Endorphin: Behavioral and analgesic activity in cats, 774 Theoretical study of effect of enzyme-enzyme interactions on /1-Endorphin: Stimulation of growth hormone release in vivo, 358 steady-state enzyme kinetics, 3632 Enkephalin: Conformational analysis by empirical energy calculations, "Virial" expansion of enzyme flux and use of quasi-chemical 414 approximation for two-state enzymes with enzyme-enzyme Immunohistochemical analysis of peptide pathways possibly related to interactions, 5227 pain and analgesia: Enkephalin and substance P, 3081 Enzyme, metallo- Neuronal actions of endorphins and enkephalins among brain regions: X-ray absorption studies of halide binding to carbonic anhydrase, 1794 Comparative microiontophoretic study, 2584 Enzyme, monocyclic cascade model Opiate peptides synthesized by a clonal pituitary tumor cell line, 2259 Superiority of interconvertible enzyme cascades in metabolic regulation: Opioid peptide enkephalin: Immunohistochemical mapping in rat central Analysis of monocyclic systems, 2761 nervous system, 2167 Downloaded by guest on September 27, 2021 Proc. 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Enzyme,multicyclic cascade model Erabutoxin Superiorityof interconvertibleenzyme cascades in metabolicregulation: Neurotoxina from venom of Philippinessea snake:Three-dimensional Analysisof multicyclicsystems, 2766 structure,971 Enzyme,proteolytic Ergot Proteolyticenzyme activation of rat ovarianadenylate cyclase, 4857 Antagonismof histamine-activatedadenylate cyclase in brain by Enzymepurification D-lysergicacid diethylamide,5697 3-Hydroxy-3-methylglutaryl-coenzymeA reductase purified from rat Brain dopaminereceptors: Detection with [3H]dihydroergocryptine,3750 liver, 1431 Erythrocyte Enzymeregulation see also Membrane,erythrocyte Homologybetween prolyl hydroxylase subunit and tissue proteinthat Abnormallithium and sodiumtransport in erythrocytesof manic patient crossreactsimmunologically with the enzyme,4420 and some membersof his family, 3607 Involvementof an internalpromoter in regulationand synthesis of b-Aminolevulinatedehydratase, uroporphyrinogen-I synthase, and mitochondrialand cytoplasmicleucyl-tRNA synthetases of protoporphyrinIX: Levels in erythrocytesfrom anemic mutant mice, Neurospora,1172 1181 Enzyme,regulatory 5'-Deoxypyridoxalas a potential anti-sicklingagent, 1721 Homoserinedehydrogenase: Spontaneous reactivation by dissociationof Effect of galactoseoxidase, with and without priorsialidase treatment, p-mercuribenzoatefrom inactiveenzyme-p-mercuribenzoate complex, on viabilityof erythrocytesin circulation,4205 4862 Enzymereplacement therapy in Gaucher'sdisease: Preliminary clinical Superiorityof interconvertibleenzyme cascades in metabolicregulation: trial of new enzymepreparation, 4620 Analysisof monocyclicsystems, 2761 Enzymicdefects in hereditarytyrosinemia, 4641 Superiorityof interconvertibleenzyme cascades in metabolicregulation: Glycophorinand the concanavalinA receptorof humanerythrocytes: Analysisof multicyclicsystems, 2786 Receptorfunction in lipid bilayers,2751 Enzymereplacement therapy Hemolysisof humanerythrocytes by transientelectric field, 1923 Enzymereplacement therapy in Gaucher'sdisease: Large-scale Human erythrocytepyrimidine 5'-nucleotidase: Purification and purificationof glucocerebrosidasesuitable for humanadministration, properties,3701 3560 Ligandkinetics of hemoglobinS containingerythrocytes, 203 Enzymespecific activity Lithium efflux throughNa/K pump in humanerythrocytes, 3099 Cryoenzymologyin mixed solvents without cosolventeffects on enzyme Membraneultrastructural changes during calcium phosphate-induced specific activity, 2297 fusion of humanerythrocyte ghosts, 2417 Enzymesubunit Monomericform of pyruvatekinase in humanpyruvate kinase Affinity labelingof -y-glutamyltranspeptidase and locationof 'y-glutamyl deficiency,501 bindingsite on light subunit,931 Role of sialic acid in survivalof erythrocytesin circulation:Interaction of Polymorphismand subunit structureof enzymes:Neutralist-selectionist neuraminidase-treatedand untreatederythrocytes with spleen and controversy,698 liver at cellularlevel, 1521 Reconstitutionof thermostableATPase capableof energycoupling from Sendai virus-inducedhemolysis: Reduction in heterogeneityof its purifiedsubunits, 936 erythrocytelipid bilayerfluidity, 1918 Subunit interactionin cyclic AMP-dependentprotein kinase of mutant Topographicseparation of adenylatecyclase and hormonereceptors in lymphomacells, 1167 plasmamembrane of toad erythrocyteghosts, 2860 Enzymesynthesis Transmembranemovement of cholesterolin human erythrocytes,1538 Productof newly identifiedgene, glnF, is requiredfor synthesis of Waldenstrommacroglobulin that is a cold agglutininand a cryoglobulin glutaminesynthetase in Salmonella, 1662 becauseit binds N-acetylneuraminosylresidues, 4591 Epidermis Erythropoiesis Dissociationof increasesin levels of 3':5'-cyclicAMP and 3':5'-cyclic Characterizationof an erythroidprecursor cell of high proliferative GMP from inductionof ornithinedecarboxylase by tumor promoter capacityin normalhuman peripheral blood, 1105 12-0-tetradecanoylphorbol-13-acetate in mouse epidermisin vivo, 657 Erythropoietin Organicacid and potassiumaccumulation in guardcells duringstomatal Erythropoietin:Isolation by affinity chromatographywith lectin-agarose opening,4434 derivatives,4633 Epididymis HemoglobinF synthesis in vitro:Control at level of primitiveerythroid 9S bindingprotein for androgensand progesterone,1960 stem cells, 2923 Epigeneticchange Hemoglobinswitching in sheep and goats:Induction of hemoglobinC Age incidencecurves for cancer,1341 synthesis in culturesof sheep fetal erythroidcells, 5078 Epigeneticvariation of culturedsomatic cells: Gradualchanges in Pure and mixed eyrthroidcolony formationin uitro stimulatedby spleen requirementfor factorspromoting cell division,2928 conditionedmedium with no detectableerythropoietin, 3879 Epilepsy Escherichiacoli Ethylphenacemideand phenacemide:Conformational similarities to Acyl groupand electronpair relay system:Network of interactinglipoyl diphenylhydantoinand stereochemicalbasis of anticonvulsantactivity, moieties in pyruvateand a-ketoglutaratedehydrogenase complexes 1264 from Escherichiacoli, 4223 Epinephrine Affinity of intact Escherichiacoli for hydrophobicmembrane probes is a Activationof cardiacadenylate cyclase: Hormonal modification of functionof the physiologicalstate of cells, 1811 magnesiumion requirement,92 A gene from Escherichiacoli affectingthe sigma factor subunit of RNA 3':5'-CyclicAMP: Independent induction of amino acid tranlsportby polymerase,1836 epinephrinein primarycultures of adult rat liver cells, 234 Aminoacid sequencefor peptide extensionon prolipoproteinof 3':5'-CyclicAMP: Independent induction of amino acid transportby Escherichiacoli outer membrane,1004 epinephrinein primarycultures of adult rat liver cells (correction), Aminoglycoside-modifyingenzyme of antibiotic-producingbacterium 2187 acts as determinantof antibioticresistance in Escherichiacoli, 999 Epstein-Barrvirus Biochemicalcharacterization of mutant lipoproteinof Escherichiacoli, Epstein-Barrviral DNAs comparedin Burkitt lymphomabiopsy cells 1388 and in cells clonallytransformed in vitro, 4651 Biosynthesisof covalentlylinked diglyceridein mureinlipoprotein of Host-determineddifferences in expressionof surfacemarker Escherichiacoli, 5318 characteristicson humanand simian lymphoblastoidcell lines Cell-cell interactionsin conjugatingEscherichia coli: Role of traT transformedby Epstein-Barrvirus, 749 protein in surfaceexclusion, 5104 Intestine as a sourceof apolipoproteinA1, 2574 Cellulardivision in Escherichiacoli: Mutant of E. coli lackinga Purifiedcomplement-fixing antigen identifiedas Epstein-Barr murein-lipoprotein,1417 virus-determinednuclear antigen by its bindingto metaphase Chemotaxisin Escherichiacoli: Methylationof che gene products,3317 chromosomes,1605 Chromosomallocation of structuralgene for RNA polymerasea factor in Transientinduction of nuclearantigen unrelatedto Epstein-Barr Escherichiacoli, 1831 nuclearantigen in cells of two humanB-lymphoma lines convertedby Cloningand mappingof replicationorigin of Escherichiacoli, 5458 Epstein-Barrvirus, 363 Codonspecificity of UGA suppressortRNATrP from Escherichiacoli, Equation,differential 5496 Existenceof a steady state in a biologicalsystem, 4182 Conditional-lethalrho mutants of Escherichiacoli: Isolationand Hyperbolicalmost periodicsolutions and toroidallimit sets, 3124 characterization,1162 Equation,Hodgkin-Huxley Conditionallylethal ribosomalprotein mutants: Locus requiredfor Subthresholdsolutions of the Hodgkin-Huxleyequations, 5199 modificationof 50S subunit proteins,467 Equation,Liouville Contrastvariation study of specificallydeuterated Escherichia coli Relaxationphenomena: A generaltreatment, 3623 ribosomal subunits, 5547 Equation,Lorentz Differential utilization of leucyl tRNAs by Escherichia coli, 1393 Minimal coupling and symplectic mechanics of a classical particle in DNA-dependent RNA polymerase involved in a recA-independent presence of Yang-Mills field, 5253 pathway of genetic recombination in Escherichia coli, 3932 Equation,partial differential Domains involving nonrandom distribution of lipopolysaccharide in Restrictions on coefficients of hyperbolic systems of partial differential outer membrane of Escherichia coli, 5065 equations, 4150 Elongation factor Tu resistant to kirromycin in Escherichia coli mutant Sufficient conditions for subellipticity on weakly pseudo-convex altered in both tuf genes, 4341 domains, 2214 Escherichia coli ribosomal protein S1 has two polynucleotide binding Equilibrium dialysis sites, 4786 Antibody affinity enhanced in sublethally irradiated mice and bone Expression in Escherichia coli K-12 of structural gene for catabolic marrow chimeras, 707 dehydroquinase of Neurospora crassa, 3508 Downloaded by guest on September 27, 2021 5808 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Extracellular labeling of nascent polypeptides traversing the membrane Estrogen regulates the vitellogenin gene, 2384 of Escherichia coli, 2830 a-Fetoprotein is not a component of estradiol receptor of rat uterus, Functional eukaryotic enzyme produced in Escherichia coli: Cloning and 2269 expression of yeast structural gene for imidazoleglycerolphosphate Ovarian "inhibin": Suppression of secondary rise in serum follicle dehydratase (his 3), 5255 stimulating hormone levels in proestrous rats by injection of porcine Functional expression of cloned yeast DNA in Escherichia coli, 487 follicular fluid, 5721 Gene fusions used to study outer membrane protein localization in Serum sex hormones and glucose, insulin, and lipid abnormalities in men Escherichia coli, 5411 with myocardial infarction, 1729 High-resolution 31p nuclear magnetic resonance studies of metabolism in Uterine peroxidase as marker for estrogen action, 3162 aerobic Escherichia coli cells, 888 Estrogen Hybrid tryptophan synthetase a chain produced by genetic exchange see also specific estrogens between Escherichia coli and Salmonella typhimurium, 286 Antibodies to estrogen receptor: Immunochemical similarity of Identification of recA (tif) gene product of Escherichia coli, 5280 estrophilin from various mammalian species, 3681 Interaction of rabbit reticulocyte ribosomes with bacteriophage fl Establishment and characterization of a strain of human adrenal tumor mRNA and of Escherichia coli ribosomes with rabbit globin mRNA, cells that secrete estrogen, 1067 2692 Estrogen regulates the vitellogenin gene, 2384 Isopeptide linkage between N-a-monomethylalanine and lysine in Uterine peroxidase as marker for estrogen action, 3162 ribosomal protein Sll from Escherichia coli, 4905 Estrophilin Large-scale automated isolation of Escherichia coli mutants with Antibodies to estrogen receptor: Immunochemical similarity of thermosensitive DNA replication, 3485 estrophilin from various mammalian species, 3681 Limited accessibility of chromatin satellite DNA to RNA polymerase Estrus from Escherichia coli, 4337 Carcass components at first estrus of rats on high-fat and low-fat diets: Mechanism of action of nalidixic acid: Purification of Escherichia coli Body water, protein, and fat, 379 nalA gene product and its relationship to DNA gyrase and a Ethacrynic acid nicking-closing enzyme, 4767 Increased dexamethasone resistance of cystic fibrosis fibroblasts, 5642 Multi-enzyme complex of fatty acid oxidation isolated from Escherichia Ethanol coli, 492 Extension of longevity in Drosophila mojavensis by environmental Mutant of Escherichia coli showing constitutive expression of lysogenic ethanol: Differences between subraces, 387 induction and error-prone DNA repair pathways, 300 Isolation of sr-alcohol dehydrogenase of human liver: Determinant of Mutant RNA polymerase in Escherichia coli: Regulation of synthesis alcoholism? 4378 and activity, 5416 Ethidium bromide Mutants of Escherichia coli lacking in highly penicillin-sensitive DNA nicking-closing enzyme encapsidated in vaccinia virus: Partial I-alanine carboxypeptidase activity, 2976 purification and properties, 1841 Mutator action by Escherichia coli strains carrying dnaE mutations, Inhibitors of genetic recombination in pneumococci, 296 3947 Mapping of closed circular DNAs by cleavage with restriction Nalidixic acid resistance: A second genetic character involved in DNA endonucleases and calibration by agarose gel electrophoresis, 851 gyrase activity, 4772 Nonintercalative binding of ethidium bromide to nucleic acids: Crystal Nonspecific DNA binding of genome-regulating proteins as biological structure of ethidium-tRNA molecular complex, 4821 control mechanism: Measurement of DNA-bound Escherichia coli lac Ethyl methanesulfonate repressor in vivo, 4228 Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to Nucleic acid reassociation kinetics: Retarded rate of hybridization of ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 RNA with excess DNA, 2306 Ethylphenacemide Nucleotide sequence of 5' end of araBAD operon messenger RNA in Ethylphenacemide and phenacemide: Conformational similarities to Escherichia coli B/r, 49 diphenylhydantoin and stereochemical basis of anticonvulsant activity, Nucleotide sequence of operator-promoter region of galactose operon of 1264 Escherichia coli, 106 Euclidean 4-space pH-conditional mutant of Escherichia coli, 5637 Deformations of instantons, 2662 30P nuclear magnetic resonance measurements of ATPase kinetics in Evolution aerobic Escherichia coli cells, 5551 Adaptive response due to changes in gene regulation: Study with Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Drosophila, 4562 prevents X repressor inactivation, ultraviolet mutagenesis, and Cost of evolution and imprecision of adaptation, 1647 filamentous growth, 1152 Design of molecular control mechanisms and demand for gene Protease inhibitor blocks SOS functions in Escherichia coli: Antipain expression, 5647 prevents X repressor inactivation, ultraviolet mutagenesis, and Dual origin of highly social behavior among bees, 1135 filamentous growth (correction), 2594 Escherichia coli 5S RNA binding proteins L18 and L25 interact with Protein X is product of recA gene of Escherichia coli, 5275 5.8S RNA but not with 5S RNA from yeast ribosomes, 2706 Release of Escherichia coli DNA from membrane complexes by Evolutionary consequences of parthenogenesis: Evidence from the single-strand endonucleases, 2756 Warramaba virgo complex, 1130 Sensory transduction in Escherichia coli: Requirement for methionine in Evolution of primate oncornaviruses: Endogenous virus from langurs sensory adaptation, 183 (Presbytis spp.) with related virogene sequences in other Old World Sensory transduction in Escherichia coli: Two complementary pathways monkeys, 4557 of information processing that involve methylated proteins, 3312 How does selection reconcile individual advantage with the good of the Sensory transduction in Escherichia coli: Role of protein methylation group? 4542 reaction in sensory adaptation, 4964 Is evolution gradual or rectangular? Evidence from living fishes, 5083 Simultaneous deletion of D-alanine carboxypeptidase IB-C and Methanogenic bacteria classified by 16S ribosomal RNA penicillin-binding component IV in mutant of Escherichia coli K12, characterization, 4537 2980 Methanogenic bacteria classified by 16S ribosomal RNA characterization Sodium-stimulated glutamate uptake in membrane vesicles of (correction), 5778 Escherichia coli: Role of ion gradients, 3167 Molecular evolution of human and rabbit /-globin mRNAs, 5618 Specialized transducing phage for initiation factor 3 gene in Escherichia Ordering of cyanogen bromide peptides of type III collagen based on coli, 3970 homology to type I collagen: Preservation of sites for crosslink Terminus region of chromosome in Escherichia coli inhibits replication formation during evolution, 84 forks, 3927 Parental investment, mate choice, and mate quality, 3476 Thermosensitive mutation in Escherichia coli simultaneously causing Partial amino-acid sequences of human and rabbit C-reactive proteins: defects in penicillin-binding protein-lBs and in enzyme activity for Homology with immunoglobulins and histocompatibility antigens, peptidoglycan synthesis vitro, 5472 1214 Transcription termination at trp, operon attenuators of Escherichia coli Phylogenetic structure of prokaryotic domain: Primary kingdoms, 5088 and Salmonella typhimurium: RNA secondary structure and Quantum yields for oxygenic and anoxygenic photosynthesis in regulation of termination, 4365 cyanobacterium Oscillatoria limnetica, 2152 Translation of Drosophila melanogaster sequences in Escherichia coli, Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, 5041 2514 Escherichia coli spheroplast Evolution, chromosomal Bacteriophage system for screening and study of biologically active Rapid speciation and chromosomal evolution in mammals, 3942 polycyclic aromatic hydrocarbons and related compounds, 1378 Evolution, molecular Ester hydrolysis Hybrid tryptophan synthetase a chain produced by genetic exchange Intramolecular general base-catalyzed ester hydrolyses by imidazolyl between Escherichia coli and Salmonella typhimurium, 286 group, 23 Oligosaccharides in human IgAl and IgA2 immunoglobulins: Location Intramolecular general base-catalyzed ester hydrolyses by imidazolyl and structural significance, 2301 group (correction), 3621 Evolution of proteins Model for "charge-relay": Acceleration by carboxylate anion in Adenosine 3':5'-cyclic monophosphate- and guanosine 3':5'-cyclic intramolecular general base-catalyzed ester hydrolysis by imidazolyl monophosphate-dependent protein kinases: Possible homologous group, 2634 proteins, 3239 Estradiol C-reactive protein and complement subcomponent Clt characterized as Coordination of ribosome content and polysome formation during homologous proteins diplaying cyclic pentameric symmetry estradiol stimulation of vitellogenin synthesis in immature male chick (pentraxins), 739 livers, 3133 Microcomplement fixation studies on evolution of s-glycerophosphate Estradiol receptor of calf uterus: Interaction with heparin-agarose and dehydrogenase within genus Drosophila, 684 purification, 4886 Structural convergence during protein evolution, 2820 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5809

Excisionrepair Fertilization Different rate-limiting steps in excision repair of ultraviolet- and see also Membrane, fertilization N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human Free calcium increases explosively in activating medaka eggs, 623 fibroblasts, 1548 Isolation of bindin: Protein responsible for adhesion of sperm to sea Specific action of T4 endonuclease V on damaged DNA in xeroderma urchin eggs, 2456 pigmentosum cells in vivo, 2958 Microsurgically produced homozygous-diploid uniparental mice, 5657 Exocytosis Festuca microstachys Control of serotonin secretion from human platelets by hydroxyl ion Polyploidy affects phosphoglucose isomerase diversity in Festuca transport and osmotic lysis, 5295 microstachys, 1652 Dimeric immunoglobulin E serves as unit signal for mast cell a-Fetoprotein degranulation, 2993 a-Fetoprotein is not a component of estradiol receptor of rat uterus, Luminal membrane retrieved after exocytosis reaches most Golgi 2269 cisternae in secretory cells, 5073 Human a-fetoprotein: Postsynthetic modification controls its Extracellularinatrix immunosuppressive potency, 3988 Synthesis of two collagen types of embryonic chick corneal epithelium in Fever vitro, 39 Human leukocytic pyrogen: Purification and development of radioimmunoassay, 4624 Fibrinolysis Fab fragment Fibrinolytic activator and inhibitor synthesized by endothelial cells, 3903 Method for localizing proteins in periodic structures: Fab fragment High-molecular-weight kininogen: Role in surface-binding and activation labeling combined with image processing of electron micrographs, 5514 of coagulation Factor XI and prekallikrein, 4636 Factor IX Fibroblast Activation of Factor IX by reaction product of tissue factor and Factor Actin microheterogeneity in chick embryo fibroblasts, 120 VII: Additional pathway for initiating blood coagulation, 5260 Antibody-induced linkages of plasma membrane proteins to intracellular Correlation of clotting protease activity in vitro and in vivo: Effect of actomyosin-containing filaments in cultured fibroblasts, 5584 heparin, 3028. Antitubulins affect redistribution of crosslinked receptors on surface of FactorVII fibroblasts and epithelial cells, 2865 Activation of Factor IX by reaction product of tissue factor and Factor Binding and internalization of thrombin by normal and transformed VII: Additional pathway for initiating blood coagulation, 5260 chick cells, 596 Factor VIII complex Cell surface-associated structural proteins in connective tissue cells, 2480 MacromolecularFactor VIII complex:Functional and structural Cell surface carbohydrates and proteins in cell behavior: Biochemical heterogeneity observed in von Willebrand swine with transfusion, 759 reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 FactorX Cell-surface glycosyltransferases in cultured fibroblasts: Increased Correlation of clotting protease activity in vitro and in vivo: Effect of activity and release during serum stimulation of growth, 1086 heparin, 3028 Cyclic AMP, microtubule-microfilament system, and cancer, 4491 Interaction of coagulation factor Xa with human platelets, 4033 Cystic fibrosis fibroblasts: Increased resistance to ouabain toxicity, 1676 Factor XI Cystinotic fibroblasts accumulate cystine from intracellular, 4505 High-molecular-weight kininogen: Role in surface-binding and activation Defective organization of actin in cultured skin fibroblasts from patients of coagulation Factor XI and prekallikrein, 4636 with inherited adenocarcinoma, 3019 FactorXII Defects of glycosyltransferase activities in human fibroblasts of pk and p High-molecular-weight kininogen: Role in surface-binding ancl activation blood group phenotypes, 5407 of coagulation Factor XI and prekallikrein, 4636 Different rate-limiting steps in excision repair of ultraviolet- and Fatty acid N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human Acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in fibroblasts, 1548 liver cell, 1497 Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby Candida lipolytica mutants defective in acyl-coenzyme A synthetase: hamster kidney 21/C13 cells and in secondary mouse embryo Isolation and fatty acid metabolism, 4947 fibroblasts C57BL/6J, 979 Endocytosis: Response to altered fatty acyl composition of macrophage Extension of lifespan of cultured normal human diploid cells by vitamin phospholipids, 4895 E: Reevaluation, 1640 Fatty acid synthetase from Brevibacterium ammoniagenes: Formation of Extinction of hemoglobin inducibility in Friend erythroleukemia cells by monounsaturated fatty acids by multienzyme complex, 3180 fusion with cytoplasm of enucleated mouse neuroblastoma or Human platelet guanylate cyclase stimulated by unsaturated fatty acid fibroblast cells, 1642 peroxides, 3657 Factor that binds glucose and stimulates its transport isolated from Morphological differentiation of neuroblastoma cells in medium normal and Rous sarcoma virus-transformed chicken fibroblasts, 163 supplemented with delipidated serum, 3893 Fibroblast heterogeneity and prostaglandin regulation of subpopulations, Precursor role of arachidonic acid in release of slow reacting substance 3429 from rat basophilic leukemia cells, 4577 Genetics of connective tissue proteins: Gene for human type I Fatty acid auxotroph procollagen assigned to chromosome 17 by analysis of cell hybrids and Lipid and proteih segregation in Escherichia coli membrane: microcell hybrids, 4444 Morphological and structural study of different cytoplasmic membrane Glucose depletion accounts for induction of two transformation-sensitive fractions, 452 membrane proteins in Rous sarcoma virus-transformed chick embryo Fatty acid oxidation fibroblasts, 3840 Multi-enzyme complex of fatty acid oxidation isolated from Escherichia Histone gene transcription activated by nonhistone chromosomal coli, 492 proteins in WI-38 human diploid fibroblasts, 173 Fatty acid synthetase Immunofluorescent staining of cytoplasmic and spindle microtubules in Fatty acid synthetase from Brevibacterium ammoniagenes: Formation of mouse fibroblasts with antibody to T protein, 2437 monounsaturated fatty acids by multienzyme complex, 31.80 Increased dexamethasone resistance of cystic fibrosis fibroblasts, 5642 Fermi-Diracintegral Induction and decay of human fibroblast interferon mRNA, 4415 Significant structure theory applied to liquid helium-3, 4739 Infectious DNA of spleen necrosis virus is integrated at a single site in Ferredoxin DNA of chronically infected chicken fibroblasts, 281 Electron paramagnetic resonance studies of photosynthetic electron Interferon messenger RNA content of human fibroblasts during transport: Photoreduction of ferredoxin and membrane-bound induction, shutoff, and superinduction of interferon production, 3409 iron-sulfur centers, 3826 Interferon production and interferon messenger RNA synthesis in Quantum efficiency of photosynthetic energy conversion, 3377 human fibroblasts, 1483 Rates of dissolution of Fe4S4 clusters of Chromatium vinosum Intracellular distributions of mechanochemical proteins in cultured high-potential iron protein and ferredoxin depend on cluster oxidation fibroblasts, 3883 state, 5231 Kinetics of processing of type I and type III procollagens in fibroblast Selective enrichment of photosynthetic electron transport nmutants,610 cultures, 3322 Ferricenium Levels of translatable mRNAs for cell surface protein, collagen n-Type Si-based photoelectrochemical cell: Liquid junction photocell precursors, and two membrane proteins are altered in Rous sarcoma using a nonaqueous ferricenium/ferrocene electrolyte, 4116 virus-transformed chick embryo fibroblasts, 3399 Ferrihemochrome Magnesium and calcium effects on uptake of hexoses and uridine by Ligands and oxidants in ferrihemochrome formation and oxidative chick embryo fibroblasts, 1585 hemolysis, 2556 Medium composition affects protein degradation and DNA synthesis in Ferrocene rat embryo, fibroblasts, 2427 n-Type Si-based photoelectrochemical cell: Liquid junction photocell Nerve growth factor secreted by L cells: Molecular properties, 1492 using a nonaqueous ferricenium/ferrocene electrolyte, 4116 Phosphohexosyl components of a lysosomal enzyme are recognized by Ferromagnetism pinocytosis a'eceptors on human fibroblasts, 2026 Crystallography of new ternary borides, 1336 Receptor diffusion on cell surfaces modulated by locally bound Crystallography of new ternary borides (correction), 3621 concanavalin A, 1110 High superconducting transition temperatures of new rare earth ternary Recessive dystrophic epidermolysis bullosa: Evidence for altered borides, 1334 collagenase in fibroblast cultures, 4646 Ferroxidase(EC 1.16.3.1) Role of surface modulating assemblies in growth control of normal and Proteolytic cleavage causes heterogeneity present in human transformed fibroblasts, 666 ceruloplasmin preparations: Chemical evidence, 5377 Simian virus 40 tumor antigen purified from a line of simian virus Fertility 40-transformed human cells, 3745 Antipainand leupeptinrestrict uterine DNA synthesis and functionin Solubilization of apolipoprotein B and its specific binding by cellular mice, 3754 receptor for low density lipoprotein, 5150 Downloaded by guest on September 27, 2021 5810 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Synthesis of human interferon by Xenopus laevis oocytes: Two noncovalent interaction of natural and synthetic fragment of the structural genes for interferons in human cells, 3287 hormone, 1016 Fibronectin Intracellular distributions of mechanochemical proteins in cultured Cell surface-associated structural proteins in connective tissue cells, 2480 fibroblasts, 3883 Extensive disulfide bonding at mammalian cell surface, 2855 Isolation and characterization of opioid peptides from rat pituitary: Fibrosarcoma /-Lipotropin, 3052 Antigenic crossreactivity to RD114 p30 protein, expressed in a human Isolation and characterization of opioid peptides from rat pituitary: fibrosarcoma cell line, 744 /-Endorphin, 4969 Suppression of production of mouse 28S ribosomal RNA in Light collection and harvesting processes in bacterial photosynthesis mouse-human hybrids segregating mouse chromosomes, 694 investigated on picosecond time scale, 1997 Filament Microenvironment of binding site in lac carrier protein, 1851 see also Microfilament Quantitative determination of transformed cells in a mixed population Filament, brain by simultaneous fluorescence analysis of cell surface and DNA in Bovine brain filament antibody localized on intermediate (100 A) individual cells, 1626 filaments in guinea pig vascular endothelial cells and chick cardiac Radiationless relaxation in "large" molecules: Preparation of true muscle cells, 662 molecular eigenstates and Born-Oppenheimer states by a coherent Filament, intermediate light source, 1310 Filaments 7-10 nm thick visualized in cultured cells of an epithelioid line Fluorescence spectroscopy (Pt K2) by immunofluorescence microscopy, 2490 Chlorophyll b identified in extracts of prokaryotic algae by fluorescence Isolation and preliminary characterization of 10-nm filaments from baby spectroscopy, 575 hamster kidney (BHK-21) cells, 2422 Fluorescent probe Filamin Affinity of intact Escherichia coli for hydrophobic membrane probes is a Interaction of filamin with F-actin in solution, 2021 function of the physiological state of cells, 1.811 Intracellular distributions of mechanochemical proteins in cultured Inhibition of cytokinesis in Friend leukemia cells by membrane mobility fibroblasts, 3883 agents, 2884 Film Lecithin bimolecular leaflets: Nuclear magnetic resonance sttudies with Structure determination of gaseous and amorphous substances by incorporated fluorescent probes, 1032 diffraction methods: Philosophical concepts and their implementation Fluoride ion (Review), 4707 Activation of cardiac adenylate cyclase: Hormonal modification oof Fish magnesium ion requirement, 92 Is evolution gradual or rectangular? Evidence from living fishes, 5083 Fluorocitrate Fish antifreeze Enzymatic formation of glutathione-citryl thioester by mitochondrial Adsorption inhibition as mechanism of freezing resistance in polar fishes, system and inhibition by (-)erythrofluorocitrate, 4942 2589 Fluorophore Fisher's "reproductive value" Use of a distant reporter group as evidence for conformational change in Generalizing Fisher's "reproductive value": Linear differential and a sensory receptor, 1932 difference equations of "dilute" biological systems, 5189 Fluvial geomorphology Generalizing Fisher's "reproductive value": Nonlinear, homogeneous, 1976 Bedload measuremeonts, East Fork River, Wyoming, 2644 biparental systems, 5772 Fly Fixed point method see Sarcophaga bullata Structure of production sets with indivisibilities, 3637 Folic acid Flagellin Pterin-6-aldehyde, a cancer cell catabolite: Identification and application Mutational analysis of developmental control in Caulobacter crescentus, in diagnosis and treatment of human cancer, 587 124 Follicle stimulating hormone Translational error theory of aging, 3396 see Follitropin Flagellum Follitropin Bacterial flagella rotating in bundles: Study in helical geometry, 221 Ovarian "inhibin": Suppression of secondary rise in serum follicle Dynein identified as outer arms of sea urchin sperm axonemes, 5006 stimulating hormone levels in proestrous rats by injection of porcine Flagellar mutants of Chlamydomonas: Studies of radial spoke-defective follicular fluid, 5721 strains by dikaryon and revertant analysis, 3456 Food web Flagellar proteins from wild-type and paralyzed mutants of Food webs and dimensionality of trophic niche space, 4533 Chlamydomonas reinhardtii: Two-dimensional analysis, 1600 Formylkynurenine Protonmotive force drives bacterial flagella, 3060 Mechanism of oxidation of tryptophan to formylkynurenine--25 years Flavin adenine dinucleotide later, 4730 Resonance coherent anti-Stokes Raman scattering spectra of fluorescent Fourier analysis biological chromophores: Vibrational evidence for hydrogen bonding of Equivalence between boundedness of certain classes of maximal and flavin to glucose oxidase and for rapid solvent exchange, 4146 multiplier operators in Fourier analysis, 423 Flavoprotein Fourier analysis on the Heisenberg group, 1328 Resonance coherent anti-Stokes Raman scattering spectra of fluorescent Frechet number biological chromophores: Vibrational evidence for hydrogen bonding of Tubular presentations sr of subsets of manifolds, 2209 flavin to glucose oxidase and for rapid solvent exchange, 4146 Free radical Flower formation Nuclear coupling of 33S and nature of free radicals in irradiated crystals Promotion and inhibition of flower formation in a dayneutral plant in of N-acetyl-L-cysteine, 216 grafts with a short-day plant and a long-day plant, 2412 Freezing point depression Flow microfluorometry Adsorption inhibition as mechanism of freezing resistance in polar fishes, Cell cycle of Saccharomyces cerevisiae in populations growing at 2589 different rates, 3850 Friedrichs model Quantitative determination of transformed cells in a mixed population Microscopic theory of irreversible processes, 4152 by simultaneous fluorescence analysis of cell surface and DNA in Friend virus individual cells, 1626 see also Leukemia virus, Friend Fluid mechanics Chromatin protein appears during erythroid differentiation of Friend Current-induced flow through living sponges in nature, 2069 virus-transformed cells, 653 Fluocinolone acetonide Chromatin protein appears during erythroid differentiation of Friend Dissociation of tumor promoter-stimulated ornithine decarboxylase virus-transformed cells (correction), 3104 activity and DNA synthesis in mouse epidermis in vivo and in vitro by Tumor promoters inhibit spontaneous and induced differentiation of' fluocinolone acetonide, a tumor-promotion inhibitor, 3908 murine erythroleukemia cells in culture, 3451 Fluorescamine Frog Quantitative determination of transformed cells in a mixed population see Dendrobates histrionicus; Rana catesbeiana; Xenopus laevls by simultaneous fluorescence analysis of cell surface and DNA in Fructose-1,6-bisphosphatase individual cells, 1626 see Hexosediphosphatase Fluorescein Fructose-bisphosphatase (EC 3.1.3.11) Food, drug, and cosmetic dyes: Biological effects related to lipid Binding of Zn2+ to rat liver fructose-1,6-bisphosphatase and its effect on solubility, 2914 catalytic properties, 2742 Fluorescein, 5-iodoacetamido- Fructose-1,6-bisphosphatase in mammalian brain, 3222 Use of a distant reporter group as evidence for conformational change in Fruiting body a sensory receptor, 1932 Major protein associated with fruiting body development in Neurospora Fluorescein, tetraiodo- and related ascomycetes, 3831 Interaction of tetraiodofluorescein with a modified form of aspartate Fumarylacetoacetase (EC 3.7.1.2) transcarbamylase, 111 Enzymic defects in hereditary tyrosinemia, 4641 Fluorescence see also Immunofluorescence /-Adrenergic receptors probed by fluorescent /-adrenergic blockers, 5290 Galactocerebroside Changes in membrane microviscosity associated with phagocytosis: C-reactive protein and complement interact with liposomes, 5672 Effects of colchicine, 1072 D-Galactose Escherichia coli ribosomal protein S1 has two polynucleotide binding see also Operon, galactose; Receptor, galactose sites, 4786 High aerobic glycolysis of rat hepatoma cells in culture: Role of Human somatotropin: Restoration of full biological activity by mitochondrial hexokinase, 3735 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5811

Galactoseepimerase Gene amplification Domains involving nonrandom distribution of lipopolysaccharide in Isolation and characterization of XpolA transducing phage, 5632 outer membrane of Escherichia coli, 5065 Selective amplification of genes on the R plasmid, NR1, in Proteus Galactoseoxidase (EC 1.1.3.9) mirabilis: Example of induction of selective gene amplification, 2518 Effect of galactose oxidase, with and without prior sialidase treatment, Gene, antibioticresistance on viability of erythrocytes in circulation, 4205 Deletions affecting transposition of antibiotic resistance gene, 702 Galactose-l-phosphateuridyltransferase (EC 2.7.7.10) Gene, bz Human gene for galactose-l-phosphate uridyltransferase assigned to Controlling element-induced alterations in UDPglucose:flavonoid chromosome 9: Studies with Chinese hamster-human somatic cell glucosyltransferase, the enzyme specified by bronze locus in maize, hybrids, 5628 5623 ,B-Galactosidase Gene, che DNA-directed synthesis in vitro of /-galactosidase: Requirement for Chemotaxis in Escherichia coli: Methylation of che gene products, 3317 ribosome release factor, 3217 Gene, cheR /-Galactosidase (EC 3.2.1.23) Protein methyltransferase identified as cheR gene product in bacterial Filamentous coliphage M13 as cloning vehicle: Insertion of Hindll sensing system, 533 fragment of lac regulatory region in M13 replicative form in vitro, Gene, chloroplast 3642 Perturbation of chloroplast DNA amounts and chloroplast gene /-Galactosidase of Escherichia coli: Amino acid sequence, 1507 transmission in Chlamydomonas reinhardtii by 5-fluorodeoxyuridine, Gene fusions used to study outer membrane protein localization in 4552 Escherichia coli, 5411 Gene cloning Key antigenic determinants in regulation of immune respone, 3984 Gene cloning for isolation of enzymes of membrane lipid synthesis: pH-conditional mutant of Escherichia coli, 5637 Phosphatidylserine synthase overproduction in Escherichia coli, 1412 Galactoside,dansyl- Gene, dna Microenvironment of binding site in lac carrier protein, 1]851 Large-scale automated isolation of Escherichia coli mutants with Galactosyltransferase thermosensitive DNA replication, 3485 Cell-surface glycosyltransferases in cultured fibroblasts: Increased Gene, dnaE activity and release during serum stimulation of growth, -1086 Mutator action by Escherichia coli strains carrying dnaE mutations, Defects of glycosyltransferase activities in human fibroblasts of pk and p 3947 blood group phenotypes, 5407 Gene, dnaG Galaxy A gene from Escherichia coli affecting the sigma factor subunit of RNA Chemical compositions of Magellanic Clouds' HII regions based on polymerase, 1836 photoelectric spectrophotometry, 5203 Chromosomal location of structural gene for RNA polymerase a factor in Discrete spiral modes in disk galaxies: Numerical examples based on Escherichia coli, 1831 density wave theory, 4726 Gene, dnaS Galaxies: Outstanding problems and instrumental prospects for the Transient accumulation of Okazaki fragments as a result of uracil coming decade (Review), 1767 incorporation into nascent DNA, 154 Gameticphase disequilibrium Gene dosage effect Theories of quasi-linkage and "affinity": Implications for population Chromosomal location of structural gene for RNA polymerase a factor in structure, 3513 Escherichia coli, 1831 Gamma-rayprobe Human gene for galactose-l-phosphate uridyltransferase assigned to Lipid vesicles in vivo: Gamma-ray perturbed angular correlation study, chromosome 9: Studies with Chinese hamster-human somatic cell 4991 hybrids, 5628 Ganglion, sensory Overexpression of an unstably inherited gene in cultured mouse cells, Immunocytochemical identification of substance P cells andl their 3956 processes in rat sensory ganglia and their terminals in spinal cord: Gene doubling Light microscopic studies, 3597 Structural heterogeneity of C2 complement protein and its genetic Ganglion,superior cervical variants in man: New polymorphism of HLA region, 1672 Determination of transmitter function by neuronal activity, 5767 Gene duplication Electrical stimulation of preganglionic nerve increases tyrosine Amino acid sequence of human prothrombin fragments 1 and 2, 1969 hydroxylase activity in sympathetic ganglia, 3078 Genetic control of mitochondrial malate dehydrogenases: Evidence for Embryologic development of mouse sympathetic ganglion in vivo and in duplicated chromosome segments, 310 vitro, 3438 Gene, env Nerve growth factor increases activity of ornithine decarboxylase in Friend strain of spleen focus-forming virus is recombinant between superior cervical ganglia of young rats, 4681 ecotropic murine type C virus and env gene region of xenotropic type Ganglion,sympathetic C virus, 4671 Nerve growth factor prevents vinblastine destructive effects on Identification of Rauscher murine leukemia virus-specific mRNAs for sympathetic ganglia in newborn mice, 5559 synthesis of gag- and env-gene products, 1855 Somatostatin-like immunoreactivity occurs in some peripheral 4 MCF murine leukemia viruses are envelope (env) gene recombinants: sympathetic noradrenergic neurons, 3587 Biochemical evidence, 4676 Ganglioside Gene expression Gangliosides and substrate analogues affect hydrolysis of nicotinamide Asparaginyl-tRNA in regulation of asparagine synthetase in a adenine dinucleotide by choleragen, 74 mammalian cell line, 2367 Glycolipid-bound sialic acid in serum: Increased levels in mice and Transcriptionally active chromatin isolated from mammalian nucleoli, 69 humans bearing mammary carcinomas, 3011 Gene fusion Ultrastructural localization of cell membrane GM1ganglioside by cholera Gene fusions used to study outer membrane protein localization in toxin, 3782 Escherichia coli, 5411 Gap junction Gene,gag Contact-mediated communication compared in normal and transformed Identification of Rauscher murine leukemia virus-specific mRNAs for human cells in culture, 4476 synthesis of gag- and env-gene products, 1855 Gaseousnebula Gene, glnF Chemical compositions of Magellanic Clouds' HII regions based on Product of newly identified gene, glnF, is required for synthesis of photoelectric speinrophotometry, 5203 glutamine synthetase in Salmonella, 1662 Gastrin Gene, globin Heptadecapeptide gastrin in vagal nerve, 5707 Cloning specific segments of mammalian genome: Bacteriophage X Gaucher'sdisease containing mouse globin and surrounding gene sequences, 4406 Enzyme replacement therapy in Gaucher's disease: Large-scale Differential effects of chemical inducers on expression of /1globin genes purification of glucocerebrosidase suitable for human administration, in murine erythroleukemia cells, 1100 3560 Hemoglobin switching in sheep and goats: Induction of hemoglobin C Enzyme replacement therapy in Gaucher's disease: Preliminary clinical synthesis in cultures of sheep fetal erythroid cells, 5078 trial of new enzyme preparation, 4620 Gene, his 3 Gene Functional eukaryotic enzyme produced in Escherichia coli: Cloning and see also Operon expression of yeast structural gene for imidazoleglycerolphosphate Expression in Escherichia coli K-12 of structural gene for catabolic dehydratase (his 3), 5255 dehydroquinase of Neurospora crassa, 3508 Gene, HLA Genes transcribed at diverse rates have similar conformation in Structural heterogeneity of C2 complement protein and its genetic chromatin, 4867 variants in man: New polymorphism of HLA region, 1672 In vitro evidence of cell-mediated immunity after exposure of mice to Gene, hprt live and inactivated rabies virus, 334 Serial transfer of human gene to rodent cells by sequential Segregation at locus determining immunoglobulin genetic marker for chromosome-mediated gene transfer, 2943 light chain variable region affects inheritance of expression of an Gene, human idiotype, 4600 Serial transfer of human gene to rodent cells by sequential Gene, A chromosome-mediated gene transfer, 2943 RNA synthesis in isolated nuclei stimulated by partially purified Gene, immuneresponse preparations of simian virus 40 T-antigen, 3189 Lymphocyte alloantigens associated with X-chromosome-linked immune Gene activation response genes, 721 Gene activation in somatic nuclei after injection into amphibian oocytes, Gene, immunoglobulin 2470 Cloning of immunoglobulin variable region gene from mouse embryo, 3518 Downloaded by guest on September 27, 2021 5812 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Location of palindromes in immunoglobulin genes, 2526 Minimal length of lactose operator sequence for specific recognition by Gene, immunoglobulin light chain lactose repressor, 966 Variable and constant parts of immunoglobulin light chain gene of a Regulation of growth hormone messenger RNA by thyroid and mouse myeloma cell are 1250 nontranslated bases apart, 5652 glucocorticoid hormones, 1816 Gene, iso-l-cytochrome c Suppression of production of mouse 28S ribosomal RNA in Enzymatic synthesis of oligonucleotides of defined sequence: Synthesis mouse-human hybrids segregating mouse chromosomes, 694 of segment of yeast iso-l-cytochrome c gene, 96 Gene, regulatory Gene, lipoprotein Genetic control of renin activity in submaxillary gland of the mouse, Biochemical characterization of mutant lipoprotein of Escherichia coli, 1185 1388 Gene, SI Gene, malic enzyme-I Molecular basis of reovirus virulence: Role of SI gene, 5744 Major histocompatibility complex assigned to a region of the short arm Gene, sarc of human chromosome 6, 1147 Cell-free synthesis of two proteins unique to RNA of transforming Major histocompatibility complex assigned to a region of the short arm virions of Rous sarcoma virus, 2011 of human chromosome 6 (correction), 5776 Gene, src Gene mapping In vitro translation yields a possible Rous sarcoma virus src gene see also Chromosome mapping product, 3302 Cell-free synthesis of precursor polypeptide for avian myeloblastosis Partial deletion and substitution of src gene in RNA genome of avian virus DNA polymerase, 4951 sarcoma virus, 4781 Cloning and mapping of replication origin of Escherichia coli, 5458 Gene, structural Codominant markers transferred by isolated metaphase chromosomes in Functional eukaryotic enzyme produced in Escherichia coli: Cloning and Chinese hamster ovary cells, 3480 expression of yeast structural gene for imidazoleglycerolphosphate Codominant markers transferred by isolated metaphase chromosomes in dehydratase (his 3), 5255 Chinese hamster ovary cells (correction), 5776 Method for cloning eukaryotic structural gene sequences (correction), DNA fragment containing origin of replication of Escherichia coli 2187 chromosome, 2720 Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, Genetic mapping of Rhizobium meliloti, 2076 2514 Genetics of connective tissue proteins: Gene for human type I Structural gene identification and mapping by DNA-mRNA procollagen assigned to chromosome 17 by analysis of cell hybrids and hybrid-arrested cell-free translation, 4370 microcell hybrids, 4444 Gene structure Human gene for galactose-l-phosphate uridyltransferase assigned to Structure of a large segment of genome of simian virus 40 that does not chromosome 9: Studies with Chinese hamster-human somatic cell encode known proteins, 827 hybrids, 5628 Structure of a large segment of the genome of simian virus 40 that does Mannosidosis: Assignment of lysosomal a-mannosidase B gene to not encode known proteins (correction), 2594 chromosome 19 in man, 2968 Gene, SUP4 Mapping of human chromosomal regions related to neoplasia: Evidence Nucleotide sequence of mutant eukaryotic gene: Yeast tyrosine-inserting from chromosomes I and 17, 5729 ochre suppressor SUP4-o, 5453 Mapping of sequences with 2-fold symmetry on simian virus 40 genome: Genetic code Photochemical crosslinking approach, 1363 Structural convergence during protein evolution, 2820 Mapping of transcription sites of simian virus 40-specific late 16S and Genetic disease 19S mRNA by electron microscopy, 496 Cystic fibrosis fibroblasts: Increased resistance to ouabaini toxicity, 1676 Microcell-mediated transfer of murine chromosomes into mouse, Chinese Genetic drift hamster, and human somatic cells, 319 Error estimate for diffusion approximation of Wright-Fisher model, 5096 Serial transfer of human gene to rodent cells by sequential Genetic organization chromosome-mediated gene transfer, 2943 Bacteriophage 0X174: Gene A overlaps gene B, 2504 Structural gene identification and mapping by DNA-mRNA Genetic recombination hybrid-arrested cell-free translation, 4370 Site-specific genetic recombination promoted in vivo by EcoRI Gene, mitochondrial restriction endonuclease, 4811 Expression of petite mitochondrial DNA in vivo: Zygotic gene rescue, Genetics 2715 see also Population genetics Gene, mitotic replication Active heteropolymeric /-glucuronidase detected in hybrids between Role of mitotic replication genes in chromosome duplication during mouse cells and human fibroblasts with f-glucuronidase deficiency, meiosis, 3951 2948 Gene, nalA Adaptive response due to changes in gene regulation: Study with Mechanism of action of nalidixic acid: Purification of Escherichia coli Drosophila, 4562 nalA gene product and its relationship to DNA gyrase and a Amber and ochre mutants of human virus Ad2+ND1 identified, 4567 nicking-closing enzyme, 4767 5-Aminolevulinate dehydratase, uroporphyrinogen-I synthase, and Nalidixic acid resistance: A second genetic character involved in DNA protoporphyrin IX: Levels in erythrocytes from anemic mutant mice, gyrase activity, 4772 1181 Gene, nif Assignment of integration site for simian virus 40 to chromosome 17 in Recombinant plasmid that carries part of nitrogen fixation (nif) gene GM54VA, a human cell line transformed by simian virus 40, 315 cluster of Klebsiella pneumoniae, 2963 Bacteriophage oX174: Gene A overlaps gene B, 2504 Gene, 0 Bidirection replication from a unique origin in a mini-F plasmid, 1138 Ribosomal mutations affect read-through of chain termination signal: Cell-cell interactions in conjugating Escherichia coli: Role of traT Synthesis of bacteriophage X 0 gene protein in vitro, 689 protein in surface exclusion, 5104 Gene, phosphoglucomutase-3 Cell-to-cell stimulation of movement in nonmotile mutants of Major histocompatibility complex assigned to a region of the short arm Myxococcus, 2938 of human chromosome 6, 1147 Chloroplast DNA distribution in parasexual hybrids shown by Major histocompatibility complex assigned to a region of the short arm polypeptide composition of fraction I protein, 5109 of human chromosome 6 (correction), 5776 Cloning of immunoglobulin variable region gene from mouse embryo, Gene, qa 3518 De novo synthesis of qa enzymes of Neurospora crassa during induction, Codominant markers transferred by isolated metaphase chromosomes in 4256 Chinese hamster ovary cells, 3480 General relativity Codominant markers transferred by isolated metaphase chromosomes in Gravitational interaction of hadrons: Band-spinor representations of Chinese hamster ovary cells (correction), 5776 GL(n,R), 4157 Conditional-lethal rho mutants of Escherichia coli: Isolation and Gene, recA characterization, 1162 DNA-dependent RNA polymerase involved in a recA-independent Controlling element-induced alterations in UDPglucose:flavonoid pathway of genetic recombination in Escherichia coli, 3932 glucosyltransferase, the enzyme specified by bronze locus in maize, Excision of F plasmid sequences by recombination at directly repeated 5623 insertion sequence 2 elements: Involvement of recA, 3965 Cystic fibrosis fibroblasts: Increased resistance to ouabain toxicity, 1676 Identification of recA (tif) gene product of Escherichia coli, 5280 Decay of genetic variability in geographically structured populations, Initiation of genetic exchanges in X phage-prophage crosses, 291 2523 Mechanism of genetic recombination: Maturation of recombination Deletions affecting transposition of antibiotic resistance gene, 702 intermediates, 4168 Design of molecular control mechanisms and demand for gene Protein X is product of recA gene of Escherichia coli, 5275 expression, 5647 Gene regulation DNA-dependent RNA polymerase involved in a recA-independent Adaptive response due to changes in gene regulation: Study with pathway of genetic recombination in Escherichia coli, 3932 Drosophila, 4562 Ecdysone: Roles in Drosophila development, 5099 De novo synthesis of qa enzymes of Neurospora crassa during induction, Error estimate for diffusion approximation of Wright-Fisher model, 5096 4256 Escherichia coli mutant with temperature sensitive function affecting Extinction of hemoglobin inducibility in Friend erythroleukemia cells by bacteriophage Q, RNA replication, 1657 fusion with cytoplasm of enucleated mouse neuroblastoma or Evolution of primate oncornaviruses: Endogenous virus from langurs fibroblast cells, 1642 (Presbytis spp.) with related virogene sequences in other Old World Gene regulation in Drosophila mulleri, D. arizonensis, and their hybrids: monkeys, 4557 Nucleolar organizer, 3498 Excision of F plasmid sequences by recombination at directly repeated Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: insertion sequence 2 elements: Involvement of recA, 3965 Increased transcription during erythroid differentiation, 2475 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) SubjectIndex 5813

Expression in Escherichia coli K-12 of structural gene for catabolic Role of mitotic replication genes in chromosome duplication during dehydroquinase of Neurospora crassa, 3508 meiosis, 3951 Gene regulation in Drosophila mulleri, D. arizonensis, and their hybrids: Segregation of genetic information for a B-tropic leukemia virus with the Nucleolar organizer, 3498 structural locus for BALB:virus-1, 2953 Genetic analysis of host range mutant viruses suggests uncoating defect Selective amplification of genes on the R plasmid, NRl, in Proteus in simian virus 40-resistant monkey cells, 3503 mirabilis: Example of induction of selective gene amplification, 2518 Genetic control of mitochondrial malate dehydrogenases: Evidence for Serial transfer of human gene to rodent cells by sequential duplicated chromosome segments, 310 chromosome-mediated gene transfer, 2943 Genetic control of renin activity in submaxillary gland of the mouse, Simple Mendelian inheritance of reiterated ribosomal DNA of yeast, 1185 5091 Genetic evidence for inducibility of recombination competence in yeast, Simultaneous deletion of D-alanine carboxypeptidase IB-C and 1667 penicillin-binding component IV in mutant of Escherichia coli K12, Genetic instability in Drosophila melanogaster: Putative multiple 2980 insertion mutants at singed bristle locus, 2973 Size-mediated onset of genetically determined maturation in platyfish, Genetic instability in Drosophila melanogaster: De novo induction of Xiphophorus maculatus, 4547 putative insertion mutations, 3490 Specialized transducing phage for initiation factor 3 gene in Escherichia Genetic mapping of Rhizobium meliloti, 2076 coli, 3970 Genetic variability maintained under mutation and selection pressures in Specific action of T4 endonuclease V on damaged DNA in xeroderma a finite population, 2509 pigmentosum cells in vivo, 2958 Human gene for galactose-l-phosphate uridyltransferase assigned to Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, chromosome 9: Studies with Chinese hamster-human somatic cell 2514 hybrids, 5628 Stable association of human transgenome and host murine chromosomes Hybrid tryptophan synthetase a chain produced by genetic exchange demonstrated with trispecific microcell hybrids, 3937 between Escherichia coli and Salmonella typhimurium, 286 Structural heterogeneity of C2 complement protein and its genetic Increased dexamethasone resistance of cystic fibrosis fibroblasts, 5642 variants in man: New polymorphism of HLA region, 1672 Infectious DNA of spleen necrosis virus is integrated at a single site in Subunit interaction in cyclic AMP-dependent protein kinase of mutant DNA of chronically infected chicken fibroblasts, 281 lymphoma cells, 1167 Inheritance of selected pathotoxin resistance in maize plants regenerated Suppression of production of mouse 28S ribosomal RNA in from cell cultures, 5113 mouse-human hybrids segregating mouse chromosomes, 694 Inhibitors of genetic recombination in pneumococci, 296 Terminus region of chromosome in Escherichia coli inhibits replication Initiation of genetic exchanges in X phage-prophage crosses, 291 forks, 3927 Interaction between mutations of ribosomes and RNA polymerase: A Theories of quasi-linkage and "affinity": Implications for population pair of strA and rif mutants individually temperature-insensitive but structure, 3513 temperature-sensitive in combination, 1157 Tritium suicide selection of mammalian cell mutants defective in Involvement of an internal promoter in regulation and synthesis of transport of neutral amino acids, 4549 mitochondrial and cytoplasmic leucyl-tRNA synthetases of Tumorigenicity of simian virus 40-transformed human cells and Neurospora, 1172 mouse-human hybrids in nude mice, 1142 Large-scale automated isolation of Escherichia coli mutants with Variable and constant parts of immunoglobulin light chain gene of a thermosensitive DNA replication, 3485 mouse myeloma cell are 1250 nontranslated bases apart, 5652 Localization of RNA polymerase in polytene chromosomes of Drosophila Variation in ability of measles virus plaque progeny to induce interferon, melanogaster, 2079 3056 Magnification of genes coding for ribosomal RNA in Saccharomyces Genetic screening cerevisiae, 1177 Human plasma proteins: High resolution two-dimensional Major histocompatibility complex assigned to a region of the short arm electrophoresis, 5421 of human chromosome 6, 1147 Genetics, somatic cell Major histocompatibility complex assigned to a region of the short arm Active heteropolymeric /-glucuronidase detected in hybrids between of human chromosome 6 (correction), 5776 mouse cells and human fibroblasts with /-glucuronidase deficiency, Mannosidosis: Assignment of lysosomal a-mannosidase B gene to 2948 chromosome 19 in man, 2968 Codominant markers transferred by isolated metaphase chromosomes in Mechanism of genetic coadaptation in populations of Drosophila Chinese hamster ovary cells, 3480 melanogaster, 324 Codominant markers transferred by isolated metaphase chromosomes in Microcell-mediated transfer of murine chromosomes into rnouse, Chinese Chinese hamster ovary cells (correction), 5776 hamster, and human somatic cells, 319 Gene for thymidine kinase transferred to thymidine kinase-deficient Microcomplement fixation studies on evolution of a-glycerophosphate human cells by purified herpes simplex viral DNA, 1590 dehydrogenase within genus Drosophila, 684 Overexpression of an unstably inherited gene in cultured mouse cells, Microsurgically produced homozygous-diploid uniparental mice, 5657 3956 Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to Serial transfer of human gene to rodent cells by sequential ouabain, 6-thioguaniine, and dibutyryl cyclic AMP, 679 chromosome-mediated gene transfer, 2943 Mutant of Escherichia coli showing constitutive expression of lysogenic Stable association of human transgenome and host murine chromosomes induction and error-prone DNA repair pathways, 300 demonstrated with trispecific microcell hybrids, 3937 Mutants of Escherichia coli lacking in highly penicillin-sensitive Genetic variability D-alanine carboxypeptidase activity, 2976 Decay of genetic variability in geographically structured populations, Mutation frequencies in female mice and estimation of genetic hazards 2523 of radiation in women, 3523 Genetic variability maintained under mutation and selection pressures in Mutator action by Escherichia coli strains carrying dnaE mutations, a finite population, 2509 3947 Gene transfer Nonsense suppressors of yeast cause osmotic-sensitive growth, 305 Overexpression of an unstably inherited gene in cultured mouse cells, Overexpression of an unstably inherited gene in cultured mouse cells, 3956 3956 Serial transfer of human gene to rodent cells by sequential Pathways of genetic transfer from Tripsacum to Zea mays, 3494 chromosome-mediated gene transfer, 2943 Perturbation of chloroplast DNA amounts and chloroplast gene Stable association of human transgenome and host murine chromosomes transmission in Chlamydomonas reinhardtii by 5-fluorodeoxyuridine, demonstrated with trispecific microcell hybrids, 3937 4552 Gene, transfer ribonucleic acid pH-conditional mutant of Escherichia coli, 5637 Identification of spacer tRNA genes in individual ribosomal RNA Physical mapping of a DNA sequence common to plasmids of transcription units of Escherichia coli, 2710 incompatibility group F I, 1190 Identification of spacer tRNA genes in individual ribosomal RNA Polymorphism and subunit structure of enzymes: Neutralist-selectionist transcription units of Escherichia coli (correction), 4706 controversy, 698 Gene translocation Polyploidy affects phosphoglucose isomerase diversity in Festuca Independent expression of gene coding for constant domain of microstachys, 1.652 immunoglobulin light chain: Sequence analyses of precursor of Product of newly identified gene, glnF, is required for synthesis of constant region polypeptide, 3157 glutamine synthetase in Salmonella, 1662 Location of palindromes in immunoglobulin genes, 2526 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Gene, traT prevents X repressor inactivation, ultraviolet mutagenesis, and Cell-cell interactions in conjugating Escherichia coli: Role of traT filamentous growth, 1152 protein in surface exclusion, 5104 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Gene, tuf prevents X repressor inactivation, ultraviolet mutagenesis, and Elongation factor Tu resistant to kirromycin in Escherichia coli mutant filamentous growth (correction), 2594 altered in both tuf genes, 4341 Rapid speciation and chromosomal evolution in mammals, 3942 Gene, unc-54 Recombinant plasmid that carries part of nitrogen fixation (nif) gene Internal deletion mutant of a myosin heavy chain in Caenorhabditis cluster of Klebsiella pneumoniae, 2963 elegans, 5336 Relative stability of a- and /-globin messenger RNAs in homozygous /+ Gene, viral thalassemia, 3960 Regulatory function of simian virus 40 DNA replication for late viral Replication and expression of plasmids from Staphylococcus aureus in gene expression, 4831 Bacillus subtilis, 1680 Gene, vitellogenin Ribosomal mutations affect read-through of chain termination signal: Estrogen regulates the vitellogenin gene, 2384 Synthesis of bacteriophage X O gene protein in uitro, 689 Geodesic Tubular presentations or of subsets of manifolds, 2209 Downloaded by guest on September 27, 2021 5814 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Geology Glucosaminephosphate isomerase (glutamine-forming) (EC 5.3.1.19) 1976 Bedload measurements, East Fork River, Wyoming, 2644 Developmental defects associated with glucosamine auxotropy in Geomagnetism Saccharomyces cerevisiae, 4351 Transient magnetic effects in scale model of earth's core, 4744 Glucose Geometry,algebraic see also Transport, glucose Calabi's conjecture and some new results in algebraic geometry, 1798 Cholesterol and lanosterol: Differential effects on artificial membranes, Geometry, symplectic 4924 Minimal coupling and symplectic mechanics of a classical particle in Factor that binds glucose and stimulates its transport isolated from presence of Yang-Mills field, 5253 normal and Rous sarcoma virus-transformed chicken fibroblasts, 163 Geophysics Glucose depletion accounts for induction of two transformation-sensitive Cyclonic mean circulation of large lakes, 2204 membrane proteins in Rous sarcoma virus-transformed chick embryo Transient magnetic effects in scale model of earth's core, 4744 fibroblasts, 3840 Germinalvesicle Glucose homeostasis during prolonged suppression of glucagon and Changes in pattern of protein synthesis during meiotic maturation of insulin secretion by somatostatin, 348 mammalian oocytes in vitro, 538 High aerobic glycolysis of rat hepatoma cells in culture: Role of Gill mitochondrial hexokinase, 3735 Calcitonin: Its hormonal action on gill, 4693 Serum sex hormones and glucose, insulin, and lipid abnormalities in men Glass with myocardial infarction, 1729 Structure determination of gaseous and amorphous substances by Glucose oxidase (EC 1.1.3.4) diffraction methods: Philosophical concepts and their implementation Resonance coherent anti-Stokes Raman scattering spectra of fluorescent (Review), 4707 biological chromophores: Vibrational evidence for hydrogen bonding of Glioblastomamultiforme flavin to glucose oxidase and for rapid solvent exchange, 4146 Hexamethylene bisacetamide induces morphologic changes and increased Glucosephosphate isomerase (EC 5.3.1.9) synthesis of procollagen in cell line from glioblastoma multiforme, Polyploidy affects phosphoglucose isomerase diversity in Festuca 5060 microstachys, 1652 Globin f-Glucosidase Authentic /-globin mRNA sequences in homozygous /0-thalassemia, Enzyme replacement therapy in Gaucher's disease: Large-scale 3047 purification of glucocerebrosidase suitable for human administration, Cellular mRNA degraded during infection by herpes simplex virus, 2370 3560 Differential effects of chemical inducers on expression of /1globin genes ,B-Glucuronidase (EC 3.2.1.31) in murine erythroleukemia cells, 1100 Active heteropolymeric /-glucuronidase detected in hybrids between Hemoglobin switching in sheep and goats: Induction of hemoglobin C mouse cells and human fibroblasts with /-glucuronidase deficiency, synthesis in cultures of sheep fetal erythroid cells, 5078 2948 Inhibition of transcription and translation of globin messenger RNA in mRNA-directed synthesis of catalytically active mouse /1-glucuronidase dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated in Xenopus oocytes, 4462 with interferon, 2036 Phosphohexosyl components of a lysosomal enzyme are recognized by Interaction of rabbit reticulocyte ribosomes with bacteriophage fl pinocytosis receptors on human fibroblasts, 2026 mRNA and of Escherichia coli ribosomes with rabbit globin mRNA, Glutamate 2692 Selective inhibition of y-glutamyl-cycle enzymes by substrate analogs, Molecular evolution of human and rabbit f-globin mRNAs, 5618 3330 Native human hemoglobin reconstituted from separated globin chains Sodium-stimulated glutamate uptake in membrane vesicles of and alloplex intermediates, 64 Escherichia coli: Role of ion gradients, 3167 Nucleotide sequences of untranslated 5' regions of human ac-and Glutamate dehydrogenase (NADP+) (EC 1.4.1.4) /1-globin mRNAs, 5145 Product of newly identified gene, glnF, is required for synthesis of Putative precursor of globin messenger RNA purified from mouse glutamine synthetase in Salmonella, 1662 nucleated erythroid cells, 178 Glutamate synthase (NADPH) (EC 1.4.1.13) Putative 15S precursor to /-globin mRNA but not to a-globin mRNA in Product of newly identified gene, glnF, is required for synthesis of Friend cells, 3184 glutamine synthetase in Salmonella, 1662 Globoside Glutamic acid Defects of glycosyltransferase activities in human fibroblasts of pk and p Selective recognition of nucleic acids by proteins: Specificity of guanine blood group phenotypes, 5407 interaction with carboxylate ions, 4872 Isoantigenic expression of Forssman glycolipid in human gastric and Glutamine colonic mucosa: Possible identity with "A-like antigen" in human Enzyme regulation in neuroblastoma cells in a salts/glucose medium: cancer, 3023 Induction of ornithine decarboxylase by asparagine and glutamine, Globulin, a2u- 3791 Multihormonal induction of hepatic a2u-globulin mRNA measured by Glutamine synthetase hybridization to complementary DNA, 4791 Superiority of interconvertible enzyme cascades in metabolic regulation: Glomerulus Analysis of multicyclic systems, 2766 Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic Glutamine-synthetase adenylyltransferase (EC 2.7.7.42) GMP in rat renal cortex: Effect of parathyroid hormone, 3569 Product of newly identified gene, glnF, is required for synthesis of Glucagon glutamine synthetase in Salmonella, 1662 Acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in Glutamine synthetase (EC 6.3.1.2) liver cell, 1497 Product of newly identified gene, glnF, is required for synthesis of Glucose homeostasis during prolonged suppression of glucagon and glutamine synthetase in Salmonella, 1662 insulin secretion by somatostatin, 348 -y-Glutamyl-cycle enzymes Hepatic nuclear guanylate cyclase: Regulation, 946 Selective inhibition of ^-glutamyl-cycle enzymes by substrate analogs, Pancreatic immunoreactive somatostatin release, 2140 3330 Thermodynamics of self-association of glucagon, 3340 'y-Glutamyl transpeptidase Glucan Affinity labeling of -y-glutamyl transpeptidase and location of -y-glutamyl Developmental defects associated with glucosamine auxotropy in binding site on light subunit, 931 Saccharomyces cerevisiae, 4351 Glutathione Glucocerebrosidase Cystinotic fibroblasts accumulate cystine from intracellular protein Enzyme replacement therapy in Gaucher's disease: Large-scale degradation, 4505 purification of glucocerebrosidase suitable for human administration, Regulation of heme pathway enzymes and cellular glutathione content 3560 by metals that do not chelate with tetrapyrroles: Blockade of metal Enzyme replacement therapy in Gaucher's disease: Preliminary clinical effects by thiols, 1875 trial of new enzyme preparation, 4620 Selective inhibition of y-glutamyl-cycle enzymes by substrate analogs, Glucocorticoid 3330 Calcium dependence of glucocorticoid-induced lymphocytolysis, 638 Soluble glutathione-dependent d5-3-ketosteroid isomerase and Dephosphorylation inactivates glucocorticoid receptors, 1398 glutathione S-transferases of liver, 158 /1-Endorphin: Pituitary and adrenal glands modulate its action, 4628 Glutathione-citryl thioester Glucocorticoid effect on level of corticotropin messenger RNA activity in Enzymatic formation of glutathione-citryl thioester by mitochondrial rat pituitary, 3283 system and inhibition by (-)erythrofluorocitrate, 4942 Glucocorticoids increase responsiveness of cells in culture to Glutathione S-transferase B (EC 2.5.1.18) prostaglandin El, 4816 Soluble glutathione-dependent d5-3-ketosteroid isomerase and Glucocorticoid-stimulated accumulation of mouse mammary tumor virus glutathione S-transferases of liver, 158 RNA: Increased rate of synthesis of viral RNA, 2879 Translation in vitro of rat liver messenger RNA coding for ligandin Regulation of growth hormone gene expression: Synergistic effects of (glutathione S-transferase B), 1899 thyroid and glucocorticoid hormones, 4293 Glyceraldehyde Gluconeogenesis Erythrocyte sickling inhibited in vitro by DL-glyceraldehyde, 367 Fructose-1,6-bisphosphatase in mammalian brain, 3222 Glycerol In vivo and in vitro phosphorylation of rat liver In vitro assembly of pure tubulin into microtubules in absence of fructose-l,6-bisphosphatase, 4615 microtubule-associated proteins and glycerol, 1860 Proline oxidase activity regulated by lactate, 5368 Glycerol-3-phosphatedehydrogenase (NAD+) (EC 1.1.1.8) Glucosamine Microcomplement fixation studies on evolution of co-glycerophosphate Developmental defects associated with glucosamine auxotropy in dehydrogenase within genus Drosophila, 684 Saccharomyces cerevisiae, 4351 Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, 2514 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5815

Glycerophospholipid Glycoside,cardiac Glycerophospholipid synthesis: Improved general method and new Cystic fibrosis fibroblasts: Increased resistance to ouabain toxicity, 1676 analogs containing photoactivable groups, 4315 Glycosyltransferase Glycine Cell-surface glycosyltransferases in cultured fibroblasts: Increased 13Cnuclear magnetic resonance studies of radiationdamage: activity and release during serum stimulation of growth, 1086 Radiation-induced degradation of glycine, 2394 Enzymatic conversion of proteins to glycoproteins, 134 Glycogen Glyoxal Amino acid sequence of rabbit muscle glycogen phosphorylase, 4762 Analysis of single- and double-stranded nucleic acids on polyacrylamide Effect of uridine on cellular UTP and glycogen synthesis in skeletal and agarose gels by using glyoxal and acridine orange, 4835 muscle: Stimulation of UTP formation by insulin, 2339 Glyoxalase Pyridoxal phosphate: Location in glycogen phosphorylase a, 4757 Living state and cancer, 2844 Glycogenphosphorylase Gold Superiority of interconvertible enzyme cascades in metabolic regulation: Structure of transition-metal cluster compounds: Use of additional Analysis of multicyclic systems, 2766 orbital resulting from f, g character of spd bond orbitals, 5235 Glycogenphosphorylase (EC 2.4.1.1) Goldfish Amino acid sequence of rabbit muscle glycogen phosphorylase, 4762 see Carassius auratus 31P nuclear magnetic resonance studies of glycogen phosphorylase from Golgi apparatus rabbit skeletal muscle: Ionization states of pyridoxal 5'-phosphate, 856 Calcium translocation by Golgi and lateral-basal membrane vesicles from Pyridoxal phosphate: Location in glycogen phosphorylase a, 4757 rat intestine: Decrease in vitamin D-deficient rats, 3612 Glycogen synthase (EC 2.4.1.11) Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich Effect of uridine on cellular UTP and glycogen synthesis in skeletal in sucrose, 3038 muscle: Stimulation of UTP formation by insulin, 2339 Fatty liver induced in Zucker "fatty" (ff/) rats by semisynthetic diet rich Glycolipid in sucrose (correction), 3550 Enzyme replacement therapy in Gaucher's disease: Preliminary clinical Golgivesicle trial of new enzyme preparation, 4620 Evidence against phospholipid asymmetry in intracellular membranes Glycolipid-bound sialic acid in serum: Increased levels in mice and from liver, 3350 humans bearing mammary carcinomas, 3011 Luminal membrane retrieved after exocytosis reaches most Golgi Isoantigenic expression of Forssman glycolipid in human gastric and cisternae in secretory cells, 5073 colonic mucosa: Possible identity with "A-like antigen" in human Gonadotropin cancer, 3023 Gonadotropin-induced regulation of luteinizing hormone receptors and Waldenstrom macroglobulin that is a cold agglutinin and a cryoglobulin desensitization of testicular 3':5'-cyclic AMP and testosterone because it binds N-acetylneuraminosyl residues, 4591 responses, 592 Glycolysis Intermediate role of adenosine 3':5'-cyclic monophosphate and protein High aerobic glycolysis of rat hepatoma cells in culture: Role of kinase during gonadotropin-induced steroidogenesis in testicular mitochondrial hexokinase, 3735 interstitial cells, 3419 Glycopeptide Gramicidin Anionicglycopeptides and glycosaminoglycanssynthesized by embryonic Biological function of gramicidin: Gramicidin-negative mutants, 780 neural tube and neural crest, 1057 Biological function of gramicidin: Selective inhibition of RNA Anionic glycopeptides and glycosaminoglycans synthesized by embryonic polymerase, 1478 neural tube and neural crest (correction), 4076 Structure of gramicidin A channel: Discrimination between srL,Dand / Glycophorin helix by electrical measurements with lipid bilayer membranes, 2402 Glycophorin and the concanavalin A receptor of human erythrocytes: Granulocyte Receptor function in lipid bilayers, 2751 Expression of Ia-like antigen molecules on human granulocytes during Glycoprotein early phases of differentiation, 4012 Antigenic distinctions of glycoproteins in plasma and mitochondrial Genetic dissection of control of normal differentiation in myeloid membranes of lymphoid cells neoplastically transformed by simian leukemic cells, 5554 virus 40, 643 Granulosisvirus Cell fusion induced by herpes simplex virus is promoted and suppressed Supercoiled circular DNA of insect granulosis virus, 3574 by different viral glycoproteins, 3913 Grasshopper Cell surface carbohydrates and proteins in cell behavior: Biochemical see Melanoplus bivittatus reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 Gravitation Changes in surface properties of normal and transformed cells caused by Electromagnetism and gravitation, 2664 tunicamycin, inhibitor of protein glycosylation, 3433 Gravitational interaction of hadrons: Band-spinor representations of Comparative rates of transfer of lipid-linked oligosaccharides to GL(n,R),4157 endogenous glycoprotein acceptors in vitro, 4411 Group contraction Envelope-glycoprotein messenger activities of avian leukosis viral RNAs: Fourier analysis on the Heisenberg group, 1328 Microinjection analysis, 1614 Growth,acid-induced Enzymatic conversion of proteins to glycoproteins, 134 Cell wall extension in Nitella as influenced by acids and ions, 1565 Erythropoietin: Isolation by affinity chromatography with lectin-agarose Growth,asymptotic derivatives, 4633 Generalizing Fisher's "reproductive value": Nonlinear, homogeneous, Extensive disulfide bonding at mammalian cell surface, 2855 biparental systems, 5772 Feline oncornavirus-associated cell-membrane antigen (FOCMA): Growthcontrol Distinction between FOCMA and the major virion glycoprotein, 1219 Local starvation for epidermal growth factor cannot explain Glycophorin and the concanavalin A receptor of human erythrocytes: density-dependent inhibition of normal human glial cells, 1619 Receptor function in lipid bilayers, 2751 Radioimmunoassay of human serum growth factor for Balb/c-3T3 cells: Glycoprotein of vesicular stomatitis virus: Synthesis and glycosylation in Derivation from platelets, 1973 vitro, 1516 Growthfactor Heavy chain of HLA antigens: Structural studies and similarity to DNA synthesis induced in BALB/c 3T3 cells by serum components: immunoglobulins, 4002 Reevaluation of commitment process, 4481 Human a-fetoprotein: Postsynthetic modification controls its Growth factor, epidermal immunosuppressive potency, 3988 Alterations in insulin binding accompanying differentiation of 3T3-L1 Lymphocyte mitogenesis induced by mammalian liver protein that preadipocytes, 4876 specifically binds desialylated glycoproteins, 676 Density-dependent regulation of growth of BSC-1 cells in cell culture: MCF murine leukemia viruses are envelope (env) gene recombinants: Control of growth by serum factors, 5046 Biochemical evidence, 4676 Local starvation for epidermal growth factor cannot explain Membrane assembly in vitro: Synthesis, glycosylation, and asymmetric density-dependent inhibition of normal human glial cells, 1619 insertion of transmembrane protein, 3278 Pro-/-nerve growth factor, a biosynthetic precursor to /-nerve growth Mobility and distribution of a cell surface glycoprotein and its factor, 3647 interaction with other membrane components, 2909 Specific radiolabeling of cell surface receptor for epidermal growth Multiple antigenic determinants on major surface glycoprotein of murine factor, 2790 mammary tumor viruses, 3564 Variants of 3T3 cells lacking mitogenic response to epidermal growth N-Acetylglucosamine incorporated into endogenous acceptors of rough factor, 3918 microsomesfrom rat liver:Stimulation by GTP after treatmentwith Growth factor, fibroblast pyrophosphate, 1095 Angiotensin stimulation of bovine adrenocortical cell growth, 5569 Phosphohexosyl components of a lysosomal enzyme are recognized by Growth factor, nerve pinocytosis receptors on human fibroblasts, 2026 Cellular adhesion altered by nerve growth factor, 4055 Protein-sugar interactions: Preparation, purification, and properties of Cholinergic metabolism and synapse formation by a rat nerve cell line, rabbit antibodies against di-N-acetylchitobiose, 168 2579 Three-dimensional structure of intact human immunoglobulin, 5140 Embryologic development of mouse sympathetic ganglion in vivo and in Transfer of mannose from mannosyl retinyl phosphate to protein, 3762 vitro, 3438 Waldenstrom macroglobulin that is a cold agglutinin and a cryoglobulin Local control of neurite development by nerve growth factor, 4516 because it binds N-acetylneuraminosyl residues, 4591 Nerve growth factor increases activity of ornithine decarboxylase in Glycosaminoglycan superior cervical ganglia of young rats, 4681 Anionic glycopeptides and glycosaminoglycans synthesized by embryonic Nerve growth factor in mouse serum and saliva: Role of submandibular neural tube and neural crest, 1057 gland, 2330 Anionic glycopeptides and glycosaminoglycans synthesized by embryonic Nerve growth factor in mouse serum and saliva: Role of submandibular neural tube and neural crest (correction), 4076 gland (correction), 4706 Downloaded by guest on September 27, 2021 5816 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Nerve growth factor prevents vinblastine destructive effects on 5'-Terminal 7-methylguanosine and mRNA function: Influence of sympathetic ganglia in newborn mice, 5559 potassium concentration on translation in vitro, 3254 Nerve growth factor receptors: Identification of distinct classes in plasma 5'-Terminal 7-methylguanosine and mRNA function: Influence of membranes and nuclei of embryonic dorsal root neurons, 2785 potassium concentration on translation in vitro (correction), 5198 Nerve growth factor receptors on human melanoma cells in culture, 565 Guanosine tetraphosphate Nerve growth factor secreted by L cells: Molecular properties, 1492 see Guanosine-5'-diphosphate-3'-diphosphate Nerve growth factor secreted in mouse saliva: Molecular properties, 2672 Guanosinetriphosphatase Pro-/-nerve growth factor, a biosynthetic precursor to /-nerve growth Guanosinetriphosphatase activity of tubulin associated with microtubule factor, 3647 assembly, 5372 Specific neural and adrenal medullary antigens detected by antisera to Light-activated GTPase in vertebrate photoreceptors: Regulation of clonal PC12 pheochromocytoma cells, 5021 light-activated cyclic GMP phosphodiesterase, 4238 Synthesis and secretion of high molecular weight form of nerve growth Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of factor by skeletal muscle cells in culture, 4496 GTP hydrolysis at regulatory site, 3307 Growth factor, serum Stoichiometry of GTP hydrolysis and tubulin polymerization, 462 Radioimmunoassay of human serum growth factor for Balb/c-3T3 cells: Guanosine 5'-triphosphate Derivation from platelets, 1973 Choleragen activation of solubilized adenylate cyclase: GTP and protein Growth, filamentous activator required for demonstration of enzymatic activity, 4396 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain N-Acetylglucosamine incorporated into endogenous acceptors of rough prevents X repressor inactivation, ultraviolet mutagenesis, and microsomes from rat liver: Stimulation by GTP after treatment with filamentous growth, 1152 pyrophosphate, 1095 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Photoaffinity analog of GTP interacts with proteins of microtubules, prevents X repressor inactivation, ultraviolet mutagenesis, and 4375 filamentous growth (correction), 2594 Proofreading of codon-anticodon interaction on ribosomes, 198 Growth hormone Stoichiometry of GTP hydrolysis and tubulin polymerization, 462 see Somatotropin Guanylate cyclase (EC 4.6.1.2) Growth hormone release inhibitory factor Activation of guanylate cyclase by superoxide dismutase and hydroxyl see Somatostatin radical: Physiological regulator of guanosine 3':5'-monophosphate Growth inhibition formation, 4360 Nonsense suppressors of yeast cause osmotic-sensitive growth, 305 Hepatic nuclear guanylate cyclase: Regulation, 946 Growth regulation Human platelet guanylate cyclase stimulated by unsaturated fatty acid Cell surface carbohydrates and proteins in cell behavior: Biochemical peroxides, 3657 reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 Nitric oxide activates guanylate cyclase and increases guanosine Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface 3':5'-cyclic monophosphate levels in various tissue preparations, 3203 membranes, 2251 Guanylic acid, 7-methyl- Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface Importance of 5'-terminal blocking structure to stabilize mRNA in membranes (correction), 4706 eukaryotic protein synthesis, 2734 Magnesium and calcium effects on uptake of hexoses and uridine by Guanylyl 5'-methylenediphosphonate chick embryo fibroblasts, 1585 Role of nucleotides in tubulin polymerization: Effect of guanylyl Medium composition affects protein degradation and DNA synthesis in 5'-methylenediphosphonate, 4881 rat embryo fibroblasts, 2427 Guanylyltransferase Role of surface modulating assemblies in growth control of normal and 5'-Terminal capping of RNA by guanylyltransferase from HeLa cell transformed fibroblasts, 666 nuclei, 3758 Sugar uptake and thymidine incorporation in mouse 3T3 cells stimulated Gut by calcium phosphate and other extracellular particles, 5593 Serotonergic neurons in peripheral nervous system: Identification in gut Guanine by immunohistochemical localization of tryptophan hydroxylase, 3086 Selective recognition of nucleic acids by proteins: Specificity of guanine Gynogenesis interaction with carboxylate ions, 4872 Microsurgically produced homozygous-diploid uniparental mice, 5657 Guanine nucleotide Gyrate atrophy Activation of cardiac adenylate cyclase: Hormonal modification of Gyrate atrophy of choroid and retina: Deficiency of ornithine magnesium ion requirement, 92 aminotransferase in transformed lymphocytes, 5159 Adenylate cyclase permanently uncoupled from hormone receptors in novel variant of S49 mouse lymphoma cells, 2016 Guanine, 6-thio- Habituation Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to Facilitation at neuromuscular junctions: Contribution to habituation and ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 dishabituation of Aplysia gill withdrawal reflex, 1267 Guanosine, acyclo- Hadron Antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine: Selectivity of Gravitational interaction of hadrons: Band-spinor representations of action, 5716 GL(n,R), 4157 Guanosine 3':5'-cyclic monophosphate in animal cells Hageman factor Activation of guanylate cyclase by superoxide dismutase and hydroxyl see Factor XII radical: Physiological regulator of guanosine 3':5'-monophosphate Haldane's dilemma formation, 4360 Cost of evolution and imprecision of adaptation, 1647 Activation of hormone-sensitive lipase and phosphorylase kinase by Halobacterium halobium purified cyclic GMP-dependent protein kinase, 4843 Molecular weight of bacteriorhodopsin solubilized in Triton X-100, 2803 Adenosine 3':5'-cyclic monophosphate- and guanosine 3':5'-cyclic Orientation of bacteriorhodopsin in Halobacterium halobium studied by monophosphate-dependent protein kinases: Possible homologous selective proteolysis, 5426 proteins, 3239 Time-resolved resonance Raman spectroscopy of bacteriorhodopsin on Cell-cycle-related changes of 3':5'-cyclic GMP levels in Novikoff the millisecond timescale, 5212 hepatoma cells, 1052 Hamster Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic Heavy water as a tool for study of forces that control length of period of GMP from induction of ornithine decarboxylase by tumor promoter the 24-hour clock of hamsters, 1295 12-0-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo, 657 Sex-limited serum protein of Syrian hamsters: Definition of female Hepatic nuclear guanylate cyclase: Regulation, 946 protein and regulation by testosterone, 730 Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic Hapten GMP in rat renal cortex: Effect of parathyroid hormone, 3569 Kinetic evidence for hapten-induced conformational transition in Mechanisms by which diazepam, muscimol, and other drugs change the immunoglobulin MOPC 460 (correction), 1301 content of cGMP in cerebellar cortex, 3592 Structure-function relations in phosphorylcholine-binding mouse Nitric oxide activates guanylate cyclase and increases guanosine myeloma protein, 2109 3':5'-cyclic monophosphate levels in various tissue preparations, 3203 Harmaline Guanosine 3':5'-cyclic monophosphate in microorganisms Mechanisms by which diazepam, muscimol, and other drugs change the 3':5'-Cyclic AMP-dependent 3':5'-cyclic GMP accumulation in content of cGMP in cerebellar cortex, 3592 Dictyostelium discoideum, 2348 Heart Guanosine 5'-diphosphate 3'-diphosphate see also Aorta; Cardiac control; Myocardial infarction Guanosine 5'-diphosphate 3'-diphosphate: In vitro degradation, 5529 Centers involved in autonomic reflex reactions originating from Inhibition of histidyl-tRNA-adenosine triphosphate stretching of the atria, 2177 phosphoribosyltransferase complex formation by histidine and by Novel prostaglandin is major product of arachidonic acid metabolism in guanosine tetraphosphate, 1535 rabbit heart, 101 mRNA-dependent in vitro synthesis of ribosomal proteins L12 and L10 Heart rate and elongation factor Tu, 5387 Interaction of myogenic and neurogenic mechanisms that control heart Guanosine, 5-iodocytidylyl(3':5')- rate, 1761 Mutagen-nucleic acid intercalative binding: Structure of Heat capacity 9-aminoacridine-5-iodocytidylyl(3'-5')guanosine crystalline complex, Heat capacity and entropy changes in processes involving proteins, 2236 188 Heisenberg chain Guanosine, 7-methyl- Explicit Plancherel theorem for ground state representation of Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins Heisenberg chain, 816 in initiation complexes, 4288 Heisenberg group 5'-Terminal capping of RNA by guanylyltransferase from HeLa cell Fourier analysis on the Heisenberg group, 1328 nuclei, 3758 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5817

Helium-3 Ligands and oxidants in ferrihemochrome formation and oxidative Significant structure theory applied to liquid helium-3, 4739 hemolysis, 2556 Helix-coil transition Sendai virus-induced hemolysis: Reduction in heterogeneity of Sequence specificity of mutagen-nucleic acid complexes in solution: erythrocyte lipid bilayer fluidity, 1918 Intercalation and mutagen-base pair overlap geometries for proflavine Hemolytic disease binding of dC-dC-dG-dG and dG-dG-dC-dC self-complementary 1-Aminolevulinate dehydratase, uroporphyrinogen-I synthase, and duplexes, 2624 protoporphyrin IX: Levels in erythrocytes from anemic mutant mice, Helminthosporium maydis 1181 Inheritance of selected pathotoxin resistance in maize plants regenerated Hemoprotein from cell cultures, 5113 Picosecond dynamics of iron proteins, 4139 Hemagglutination Hemostasis Sendai virus-induced hemolysis: Reduction in heterogeneity of Interaction of coagulation factor Xa with human platelets, 4033 erythrocyte lipid bilayer fluidity, 1918 Macromolecular Factor VIII complex: Functional and structural Hemagglutinin heterogeneity observed in von Willebrand swine with transfusion, 759 Conversion of incomplete antibodies to direct agglutinins by mild Heparin reduction: Segmental flexibility within Fc fragment of Correlation of clotting protease activity in vitro and in vivo: Effect of immunoglobulin G, 2531 heparin, 3028 Hematin Estradiol receptor of calf uterus: Interaction with heparin-agarose and Postulated deficiency of hepatic heme and repair by hematin infusions in purification, 4886 "inducible" hepatic porphyrias, 2118 Human platelet factor 4: Amino acid sequence, 2256 Heme Nucleoplasmic RNA: Definition of subclasses, 5011 1-Aminolevulinate dehydratase, uroporphyrinogen-I synthase, and Hepatitis B protoporphyrin IX: Levels in erythrocytes from anemic mutant mice, Association of e antigen with Dane particle DNA in sera from 1181 asymptomatic carriers of hepatitis B surface antigen, 2149 Energy-structure correlation in metalloporphyrins and control of oxygen Hepatitis B surface antigen: Partial amino-acid sequence of two major binding by hemoglobin, 1789 component polypeptides, 1530 Excited state lifetimes in cytochromes measured from Raman scattering Host specificity of serum marker for hepatitis B: "e antigen" has data: Iron-porphyrin interactions, 2607 properties of an immunoglobulin, 1702 Postulated deficiency of hepatic heme and repair by hematin infusions in Sex differences in response to hepatitis B infection among patients "inducible" hepatic porphyrias, 2118 receiving chronic dialysis treatment, 2561 Rat liver factor that inhibits initiation of protein synthesis in rabbit Hepatocyte reticulocyte lysates, 2264 Polypeptide hormone binding sites in vivo: Initial localization of Regulation of heme pathway enzymes and cellular glutathione content 125I-labeled insulin to hepatocyte plasmalemma visualized by electron by metals that do not chelate with tetrapyrroles: Blockade of metal microscope radioautography, 5051 effects by thiols, 1875 Specific factors influencing histotypic aggregation of chick embryo Semisynthetic cytochrome c, 4248 hepatocytes, 4486 Structure of cytochrome c555of Chlorobium thiosulfatophilum: Primitive Hepatoma low-potential cytochrome c, 5244 Human a-fetoprotein: Postsynthetic modification controls its Heme oxygenase (decyclizing) (EC 1.14.99.3) immunosuppressive potency, 3988 Regulation of heme pathway enzymes and cellular glutathione content Herpes simplex virus by metals that do not chelate with tetrapyrroles: Blockade of metal Antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine: Selectivity of effects by thiols, 1875 action, 5716 Hemin Cell fusion induced by herpes simplex virus is promoted and suppressed Mechanism of translational control by hemin in reticulocyte lysates, 3326 by different viral glycoproteins, 3913 Hemodialysis Cellular mRNA degraded during infection by herpes simplex virus, 2370 Sex differences in response to hepatitis B infection among patients Deoxycytidine deaminase activity induced in mammalian cell lines by receiving chronic dialysis treatment, 2561 infection with herpes simplex virus type 1, 1734 Hemoglobin Gene for thymidine kinase transferred to thymidine kinase-deficient see also Oxyhemoglobin human cells by purified herpes simplex viral DNA, 1590 Bonding of FeO2 in hemoglobin and related dioxygen complexes, 1780 Virion polypeptides identified in hamster cells transformed by herpes 5'-Deoxypyridoxal as a potential anti-sickling agent, 1721 simplex virus type 1, 372 Dioxygen bonding in hemoglobin: Molecular description, 1315 Herpesvirus saimiri Disagreement between calorimetric and van't Hoff enthalpies of Isolation of virus-free Herpesvirus saimiri antigen-positive plasma assembly of protein supramolecular structures, 2002 membrane vesicles, 2546 Energy-structure correlation in metalloporphyrins and control of oxygen Heteroduplex analysis binding by hemoglobin, 1789 Avian RNA tumor viruses: Heteroduplex analysis, 477 Extinction of hemoglobin inducibility in Friend erythroleukemia cells by Heteroploid conversion fusion with cytoplasm of enucleated mouse neuroblastoma or Heteroploid conversion of human skin cells by methylcholanthrene, 2451 fibroblast cells, 1642 Heterozygosity Hemoglobin switching in sheep and goats: Induction of hemoglobin C Genetic variability maintained under mutation and selection pressures in synthesis in cultures of sheep fetal erythroid cells, 5078 a finite population, 2509 Kinetics of alkaline tetramer to dimer dissociation in liganded human Heramethylene bisacetamide hemoglobin: Laser light-scattering stopped-flow study, 3814 Hexamethylene bisacetamide induces morphologic changes and increased Kinetics of hemoglobin-carbon monoxide reactions measured with a synthesis of procollagen in cell line from glioblastoma multiforme, superconducting magnetometer: Method for fast reactions in solution, 5060 2620 Hexokinase-C Ligands and oxidants in ferrihemochrome formation and oxidative Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, hemolysis, 2556 2514 Low-molecular-weight peptide inhibits RNA synthesis in houman Hexokinase (EC 2.7.1.1) leukemic and phytohemagglutinin-stimulated leukocytes and globin High aerobic glycolysis of rat hepatoma cells in culture: Role of mRNA transcription in differentiating Friend cells, 3869 mitochondrial hexokinase, 3735 Native human hemoglobin reconstituted from separated globin chains Hexose and alloplex intermediates, 64 Magnesium and calcium effects on uptake of hexoses and uridine by Pressure affects visible spectra of complexes of myoglobin, hemoglobin, chick embryo fibroblasts, 1585 cytochrome c, and horse radish peroxidase, 1 Hexosediphosphatase (EC 3.1.3.11) Soluble ATP-dependent proteolytic system responsible for degradation In vivo and in vitro phosphorylation of rat liver of abnormal proteins in reticulocytes, 54 fructose-1,6-bisphosphatase, 4615 Stereochemical trigger that initiates cooperative interaction of Histaminase hemoglobin subunits: Emission Mossbauer study, 4996 see Amine oxidase (pyridoxal-containing) Tertiary structural change in hemoglobin: Mechanism, 801 Histamine Thermodynamic aspects of linkage between binding of chloride and Activation of cardiac adenylate cyclase: Hormonal modification of oxygen to human hemoglobin, 4135 magnesium ion requirement, 92 Tumor promoters inhibit spontaneous differentiation of Friend Antagonism of histamine-activated adenylate cyclase in brain by erythroleukemia cells in culture, 2894 D-lysergic acid diethylamide, 5697 Hemoglobin F Dimeric immunoglobulin E serves as unit signal for mast cell Hemoglobin F synthesis in vitro: Control at level of primitive erythroid degranulation, 2993 stem cells, 2923 Synthetic peptides with biological activities and specificity of human HemoglobinS C3a anaphylatoxin, 1826 Alternative aspirins as antisickling agents: Acetyl-3,5-dibromrnosalicylic Histidine acid, 5499 see also Operon, histidine Electron microscopy of fibers and discs of hemoglobin S having sixfold Inhibition of histidyl-tRNA-adenosine triphosphate symmetry, 5538 phosphoribosyltransferase complex formation by histidine and by Erythrocyte sickling inhibited in vitro by DL-glyceraldehyde, 367 guanosine tetraphosphate, 1535 Ligand kinetics of hemoglobin S containing erythrocytes, 203 Histochemistry Oligopeptides as potential antiaggregation agents for deoxyhemoglobin Synaptic acetylcholine receptor sites identified in retina with S, 5431 peroxidase-labeled ao-bungarotoxin, 3268 Hemolysis Histocompatibilitycomplex Hemolysis of human erythrocytes by transient electric field, 1923 see also Antigen, histocompatibility; Major histocompatibility complex Downloaded by guest on September 27, 2021 5818 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Antigenic complex recognized by T lymphocytes: Specific sensitization Hybrid cell, human X Chinese hamster by antigens associated with allogeneic macrophages, 2104 Human gene for galactose-l-phosphate uridyltransferase assigned to Chemical characterization of murine Ia alloantigens determined by chromosome 9: Studies with Chinese hamster-human somatic cell I-E/I-C subregions of H-2 complex, 5131 hybrids, 5628 Reduction of syngeneic tumor growth by anti-I-J alloantiserum, 5118 Major histocompatibility complex assigned to a region of the short arm Structure of murine Ia antigens: Partial NH2-terminal amino-acid of human chromosome 6, 1147 sequences of products of I-E or I-C subregion, 5135 Major histocompatibility complex assigned to a region of the short arm Histogenesis of human chromosome 6 (correction), 5776 Specific factors influencing histotypic aggregation of chick embryo Hybrid cell, mouse X hamster hepatocytes, 4486 Microcell-mediated transfer of murine chromosomes into mouse, Chinese Histone hamster, and human somatic cells, 319 Arrangement of subunits in assembled histone H4 fibers, 3772 Hybrid cell, mouse X human Chromatin protein appears during erythroid differentiation of Friend Active heteropolymeric /-glucuronidase detected in hybrids between virus-transformed cells, 653 mouse cells and human fibroblasts with /-glucuronidase deficiency, Chromatin protein appears during erythroid differentiation of Friend 2948 virus-transformed cells (correction), 3104 Assignment of integration site for simian virus 40 to chromosome 17 in Chromatin subunits from baker's yeast: Isolation and partial GM54VA, a human cell line transformed by simian virus 40, 315 characterization, 1343 Genetics of connective tissue proteins: Gene for human type I Crosslinked histone octamer as model of nucleosome core, 2780 procollagen assigned to chromosome 17 by analysis of cell hybrids and Crosslinked histone octamer as model of nucleosome core (correction), microcell hybrids, 4444 5198 Intestine as a source of apolipoprotein A1, 2574 Histone and DNA synthesis: Noncoincidence in cleavage cycles of early Microcell-mediated transfer of murine chromosomes into mouse, Chinese development, 5016 hamster, and human somatic cells, 319 Histone gene transcriptiono activated by nonhistone chromosomal Stable association of human transgenomneand host murine chromosomes proteins in WI-38 human diploid fibroblasts, 173 demonstrated with trispecific microcell hybrids, 3937 Histone H3 disulfide diimers and nucleosome structure, 5519 Suppression of production of mouse 28S ribosomal RNA in Histones: Metabolism in simian virus 40-infected cells and incorporation mouse-human hybrids segregating mouse chromosomes, 694 into virions, 2805 Tumorigenicity of simian virus 40-transformed human cells and Involvement of histone Hi in organization of chromosome fiber, 1879 mouse-human hybrids in nude mice, 1142 Isopeptide linkage between nonhistone and histone 2A polypeptides of Hybrid cell, mouse X mouse chromosomal conjugate-protein A24, 864 Microcell-mediated transfer of murine chromosomes into mouse, Chinese Mechanism of phosphorylation of synthetic polypeptides by calf thymus hamster, and human somatic cells, 319 cyclic AMP-dependent protein kinase, 4261 Hybrid cell, mouse myeloma X spleen Physical properties of chemically acetylated rat liver chromatin, 3244 Antibodies against influenza virus produced by somatic cell hybrids Protein A24 in rat liver nucleosomes, 5492 between mouse myeloma and primed spleen cells, 2985 Protein scaffold isolated from mitotic HeLa cell chromosomes, 4937 Hybrid cell, neuroblastoma X glioma Structure of histone HI-DNA complex: Effect of histone HI on DNA Endogenous nonpeptide morphine-like compound: Binding to opiate condensation, 4852 receptors, 4927 Subunit structure of chromatin and organization of eukaryotic highly Opiate-dependent modulation of adenylate cyclase, 3365 repetitive DNA: Nucleosomal proteins associated with highly Hybrid element method repetitive mammalian DNA, 3297 General variational principles applicable to the hybrid element method, Histrionicotoxin 2595 Histrionicotoxin enhances agonist-induced desensitization of Hybridization, molecular acetylcholine receptor, 5754 Distribution of rat liver albumin RNA in membrane-bound and free Perhydrohistrionicotoxin: Potential ligand for ion conductance polyribosomes as determined by molecular hybridization, 5397 modulator of acetylcholine receptor, 2172 Friend strain of spleen focus-forming virus is recombinant between Hodgkin's disease ecotropic murine type C virus and env gene region of xenotropic type Growth of cultured cells from patients with Hodgkin's disease and C virus, 4671 transplantation into nude mice, 754 Glucocorticoid-stimulated accumulation of mouse mammary tumor virus Rauscher-leukemia-virus-related sequences in human DNA: Presence in RNA: Increased rate of synthesis of viral RNA, 2879 some tissues of some patients with hematopoietic neoplasias and Loop structures in hybrids of early RNA and separated strands of absence in DNA from other tissues, 353 adenovirus DNA, 4392 Homogeneous complex manifold MCF murine leukemia viruses are envelope (enu) gene recombinants: Theorems of Barth-Lefschetz type for complex subspaces of Biochemical evidence, 4676 homogeneous complex manifolds, 1332 Molecular hybridization used to purify and analyze albumin messenger Homoserine dehydrogenase (EC 1.1.1.3) RNA from rat liver, 4346 Homoserine dehydrogenase: Spontaneous reactivation by dissociation of Segregation of genetic information for a B-tropic leukemia virus with the p-mercuribenzoate from inactive enzyme-p-mercuribenzoate complex, structural locus for BALB:virus-1, 2953 4862 Hybridization, nucleic acid Hormone Endogenous new world primate retrovirus: Interspecies antigenic see also Prohormone; Receptor, hormone; specific hormones determinants shared with major structural protein of type-D RNA Multihormonal induction of hepatic Co2u-globulinmRNA measured by viruses of old world monkeys, 5734 hybridization to complementary DNA, 4791 Epstein-Barr viral DNAs compared in Burkitt lymphoma biopsy cells Hormone binding site and in cells clonally transformed in vitro, 4651 Polypeptide hormone binding sites in vivo: Initial localization of Evolution of primate oncornaviruses: Endogenous virus from langurs 125I-labeled insulin to hepatocyte plasmalemma visualized by electron (Presbytis spp.) with related virogene sequences in other Old World microscope radioautography, 5051 monkeys, 4557 Hormone, gastrointestinal Rauscher-leukemia-virus-related sequences in human DNA: Presence in Vasoactive intestinal polypeptide in brain: Localization in and release some tissues of some patients with hematopoietic neoplasias and from isolated nerve terminals, 3424 absence in DNA from other tissues, 353 Hormone, glucocorticoid RNA of avian acute leukemia virus MC29, 4320 Regulation of growth hormone messenger RNA by thyroid and Single-stranded DNA from oncornavirus-infected cells enriched in glucocorticoid hormones, 1816 virus-specific DNA sequences, 3720 Hormone, inhibitor Hybridization, ribonucleic acid-deoxyribonucleic acid Relative conformational rigidity in oxytocin and Analysis of polyoma virus nuclear RNA by mini-blot hybridization, 31.38 [1-penicillamine]oxytocin: Relationship of conformational flexibility to Avian RNA tumor viruses: Heteroduplex analysis, 477 peptide hormone agonism and antagonism, 1373 Cloned segment of Drosophila melanogaster rDNA containing new types Hormone, stimulation by of sequence insertion, 4932 Novel prostaglandin is major product of arachidonic acid metabolism in Detection of specific RNAs in agarose gels by transfer to rabbit heart, 101 diazobenzyloxymethyl-paper and hybridization with DNA probes, 5350 Hormone, thyroid HeLa cell poly(A)- mRNA codes for subset of poly(A)+ mRNA-directed see also Triiodothyroxin proteins with actin as major product, 4801 Regulation of growth hormone messenger RNA by thyroid and Human placental lactogen mRNA and its structural genes during glucocorticoid hormones, 1816 pregnancy: Quantitation with complementary DNA, 1024 Horse radish peroxidase Identification of spacer tRNA genes in individual ribosomal RNA see Peroxidase transcription units of Escherichia coli, 2710 Human placental lactogen Identification of spacer tRNA genes in individual ribosomal RNA Human placental lactogen mRNA and its structural genes during transcription units of Escherichia coli (correction), 4706 pregnancy: Quantitation with complementary DNA, 1024 Inhibition of transcription and translation of globin messenger RNA in Humoral immune response dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated Humoral immune response of NIH Swiss and SWR/J mice to vaccination with interferon, 2036 with formalinized AKR or Gross murine leukemia virus, 343 Mapping of transcription sites of simian virus 40-specific late 16S and Hybrid cell 19S mRNA by electron microscopy, 496 Extinction of hemoglobin inducibility in Friend erythroleukemia cells by Mutant RNA polymerase in Escherichia coli: Regulation of synthesis fusion with cytoplasm of enucleated mouse neuroblastoma or and activity, 5416 fibroblast cells, 1642 Nucleic acid reassociation kinetics: Rate of hybridization of excess RNA Mannosidosis: Assignment of lysosomal do-mannosidase B gene to with DNA, compared to rate of DNA renaturation, 1020 chromosome 19 in man, 2968 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5819

Nucleic acid reassociation kinetics: Retarded rate of hybridization of' Hyperbolicsystem RNA with excess DNA, 2306 Restrictions on coefficients of hyperbolic systems of partial differential Regulation of growth hormone messenger RNA by thyroid and equations, 4150 glucocorticoid hormones, 1816 Hypergeometricseries RNA maturation: Leader sequences of simian virus 40 mRNA are not MacMahon's conjecture on symmetric plane partitions, 426 transcribed adjacent to coding sequences, 3686 Hyperlipidemia Sequence arrangement of 5' ends of simian virus 40 16S and 19S Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich mRNAs, 4982 in sucrose, 3038 Spliced segments at 5' terminus of adenovirus 2 late mRNA, 3171 Fatty liver induced in Zucker "fatty" (ff//)rats by semisynthetic diet rich Structural gene identification and mapping by DNA-mRNA in sucrose (correction), 3550 hybrid-arrested cell-free translation, 4370 Hyper-/-lipoproteinemia Tadpole and adult globin RNA sequences in oocytes of Xenopus laevis, Solubilization of apolipoprotein B and its specific binding by cellular 3835 receptor for low density lipoprotein, 5150 5'-Terminal sequences and coding region of late simian virus 40 mRNAs Hypermomentum are derived from noncontiguous segments of viral genome, 5323 Gravitational interaction of hadrons: Band-spinor representations of' Hydrazine GL(n,R), 4157 Method for sequencing DNA, 560 Hyperpolarization Hydrocarbon metabolism Effects of thyrotropin on thyroid cell membrane: Hyperpolarization Heteroploid conversion of human skin cells by methylcholanthrene, 2451 induced by hormone-receptor interaction, 2352 Hydrocarbon, polycyclic aromatic Hypertension Bacteriophage system for screening and study of biologically active Collagen biosynthesis in blood vessels and other tissues reduced by polycyclic aromatic hydrocarbons and related compounds, 1378 reserpine and hypophysectomy, 777 Mechanism of phage oX174 DNA inactivation by Reduction of blood pressure and vascular collagen in hypertensive rats benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, 3335 by /-aminopropionitrile, 360 Mutagenicity and cytotoxicity of benz[a]anthracene diol epoxides and Hypertonic medium tetrahydro-epoxides: Exceptional activity of bay region 1,2-epoxides, Ligand-independent cap formation: Redistribution of surface receptors 2746 on mouse lymphocytes and thymocytes in hypertonic medium, 4511 Hydrocarbon solubility Hypoglycemia Use of solvent cavity area and number of packed solvent molecules Transplantable insulinoma in rat, 628 around a solute in regard to hydrocarbon solubilities arid hydrophobic Hypophysectomy interactions, 4144 Collagen biosynthesis in blood vessels and other tissues reduced by Hydrocortisone reserpine and hypophysectomy, 777 Developmental control of messenger RNA for hepatic tryptophan Hypothalamus 2,3-dioxygenase, 5392 Corticotropin in brain of normal and hypophysectomized rats, 648 Temporal sequence of hormonal interactions during prereplicative phase Thyrotropin-releasing hormone-like material in rat retina: Changes due of quiescent cultured 3T3 fibroblasts, 3845 to environmental lighting, 3579 Hydrodynamics Hypoxanthinephosphoribosyltransferase (EC 2.4.2.8) Current-induced flow through living sponges in nature, 2069 Contact-mediated communication compared in normal and transf'ormed Hydrogen human cells in culture, 4476 Chromatium hydrogenase, 861 Mosaic mice with teratocarcinoma-derived mutant cells deficient in Surface, catalytic, and magnetic properties of' small iron particles: Effect hypoxanthine phosphoribosyltransferase, 5564 of chemisorption of hydrogen on magnetic anisotropy, 806 Overexpression of an unstably inherited gene in cultured mouse cells, Hydrogenase 3956 Chromatium hydrogenase, 861 Serial transfer of human gene to rodent cells by sequential Hydrogen bond chromosome-mediated gene traonsfer,2943 Selective recognition of nucleic acids by proteins: Specificity of guanine Tryptic peptide analysis of normal and mutant forms of hypoxanthine interaction with carboxylate ions, 4872 phosphoribosyltransferase from HeLa cells, 926 Water molecules: Arrangement in cavities and channels of lattice of Hysteresis [Phe4Val6]antamanide dodecahydrate, 2602 Kinetic and electrochemical memory in enzyme membranes, 5314 Hydrogen peroxide "Virial" expansion of' enzyme flux and use of quasi-chemical Activation of guanylate cyclase by superoxide dismutase and hydroxyl approximation for two-state enzymes with enzyme-enzyme radical: Physiological regulator of guanosine 3':5'-monophosphate interactions, 5227 formation, 4360 Hydroperoxyflavin, 4a- Chemiluminescent reactions and electrophilic oxygen donating ability of ICR 191 4a-hydroperoxyflavins: Preparation of N5-alkyl-1,5-dihydroflavins, 405 Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to Hydrophilicity ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 Hydrophobicity, hydrophilicity, and radial and orientational Idiotype distributions of residues in native proteins, 5248 Segregation at locus determining immunoglobulin genetic marker for Hydrophobic effect light chain variable region affects inheritance of expressionl of an Heat capacity and entropy changes in processes involving proteins, 2236 idiotype, 4600 Hydrophobic interaction Idiotypicdeterminant Use of solvent cavity area and number of packed solvent molecules Binding to idiotypic determinants of large proportions of thymus-derived around a solute in regard to hydrocarbon solubilities and hydrophobic lymphocytes in idiotypically suppressed mice, 2084 interactions, 41.44 Idiotypicnetwork Hydrophobicity Idiotypic regulation of immune system by induction of antibodies agailnst Hydrophobicity, hydrophilicity, and radial and orientational anti-idiotypic antibodies, 5126 distributions of residues in native proteins, 5248 Idiotypicrepertoire 3-Hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits, 5122 Multi-enzyme complex of fatty acid oxidation isolated from Escherichia Imidazole coli, 492 Imidazole: Selective inhibitor of thromboxane synthetase in human Hydroxylamine platelets, 1716 Strand breakage by DNA untwisting enzyme results in covalent Imidazoleglycerolphosphatedehydratase (EC 4.2.1.19) attachment of enzyme to DNA, 3800 Functional eukaryotic enzyme produced in Escherichia coli: Cloning and Hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) expression of yeast structural gene for imidazoleglycerolphosphate Cholesterol synthesis in rat adrenal gland regulated through coordinate dehydratase (his 3), 5255 control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and Imidazolyl reductase activities, 1421 Intramolecular general base-catalyzed ester hydrolyses by imidazolyl 25-Hydroxycholesterol and cholesterol bind to different cytoplasmic group, 23 proteins, 2500 Intramolecular general base-catalyzed ester hydrolyses by the imidazolyl 3-Hydroxy-3-methylglutaryl-coenzyme A reductase purified from rat group (correction), 3621 liver, 1431 Model for "charge-relay": Acceleration by carboxylate anioonino Regulation of cholesterol biosynthesis by normal and leukemic (L2C) intramolecular general base-catalyzed ester hydrolysis by inmidazolyl guinea pig lymphocytes, 956 group, 2634 Hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) Immuneregulation Cholesterol synthesis in rat adrenal gland regulated through coordinate Binding to idiotypic determinants of large proportions of thymus-derived control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and lymphocytes in idiotypically suppressed mice, 20(84 reductase activities, 1421 Potentiation of primary in vivo antibody response by alloantisera against Hydroxyproline gene products of I region of H-2 complex, 3975 Collagen degradation in rat skin but not in intestine during rapid Immuneresponse growth: Effect on collagen types I and III fromoskin, 1436 Immune surveillance against virus-induced tumors and nonrejectaoility Homology between prolyl hydroxylase subunit and tissue protein that of spontaneous tumors: Contrasting consequences of host versus tumor crossreacts immunologically with the enzyme, 4420 evolution, 2121 Hymenoptera Key antigenic determinants in regulation of immune respone, 3984 Dual origin of highly social behavior among bees, 1135 Lymphocyte alloantigens associated with X-chromosome-linked immoune Hyperactivity response genes, 721 L-3,4-Dihydroxyphenylalanine-induced hypersensitivity simulating Reduction of syngeneic tumor growth by anti-I-J alloantiserum, 5118 features of denervation, 2126 Downloaded by guest on September 27, 2021 5820 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Suppressor cell regulation of immune response to tumors: Abrogation by Dimeric immunoglobulin E serves as unit signal for mast cell adult thymectomy, 2989 degranulation, 2993 Immune surveillance Direct demonstration of murine thymus-dependent cell surface Host specificity of serum marker for hepatitis B: "e antigen" has endogenous immunoglobulin, 2113 properties of an immunoglobulin, 1702 Hybridization properties of immunoglobulin mRNA: Failure to detect Immune surveillance against virus-induced tumors and nonrejectability covalently associated IgG mRNA transcripts of reiterated and unique of spontaneous tumors: Contrasting consequences of host versus tumor mouse DNA, 3528 evolution, 2121 Immunoglobulin-dependent antigen-specific helper T cell, 4582 Systemic alteration induced in mice by ultraviolet light irradiation and Ligand-independent cap formation: Redistribution of surface receptors its relationship to ultraviolet carcinogenesis, 1688 on mouse lymphocytes and thymocytes in hypertonic medium, 4511 Immune system Long-range conformational change induced by antigen binding to IgM Idiotypic regulation of immune system by induction of antibodies against antibody, 5682 anti-idiotypic antibodies, 5126 Membrane-controlled depletion of complement activity by Immunity, cell-mediated spin-label-specific IgM, 3537 Heterogeneity of cytotoxic response of thymus-derived lymphocytes after Molecular weight and valence of cell-surface receptor f'or immunization with influenza viruses, 1209 immunoglobulin E, 869 In vitro evidence of cell-mediated immunity after exposure of mice to Multispecific lymphoid cell surface receptors, 1224 live and inactivated rabies virus, 334 Oligosaccharides in human IgAl and IgA2 immunoglobulins: Location Thymosin o(Y:Isolation and sequence analysis of immunologically active and structural significance, 2301 thymic polypeptide, 725 Partial amino-acid sequences of human and rabbit C-reactive proteins: Immunity, nonspecific. Homology with immunoglobulins and histocompatibility antigens, Enhancement of nonspecific immunity to Klebsiella pneumoniae 1214 infection by a synthetic immunoadjuvant Primary structure of human C-reactive protein, 3148 (N-acetylmuramyl-l,-alanyl-D-isoglutamine) and several analogs, 2089 Segregatioonat locus determining immunoglobulin genetic marker for Immunoadjuvant light chain variable region affects inheritance of expression of an Enhancement of nonspecific immunity to Klebsiella pneumoniae idiotype, 4600 infection by a synthetic immunoadjuvant Sequence variability in immunoglobulins: Structural implications, 2551 (N-acetylmuramyl-LI-alanyl-D-isoglutamine) and several analogs, 2089 Suppression of immunoglobulin synthesis and secretion by peripheral Immunocytochemistry blood lymphocytes from normal donors, 2099 Immunocytochemical identification of substance P cells and their Three-dimensional structure of intact human immunoglobulin, 5140 processes in rat sensory ganglia and their terminals in spinal cord: Variable and constant parts of immunoglobulin light chain gene of a Light microscopic studies, 3597 mouse myeloma cell are 1250 nontranslated bases apart, 5652 /-ILipotropin: Localization of cells and axons in rat brain by Immunoglobulin heavy chain immunocytochemistry, 5155 Amino acid sequence of precursor region of MOPC-315 mouse Ultrastructural identification of substance P cells and their processes in immunoglobulin heavy chaino,5692 rat sensory ganglia and their terminals in spinal cord by Amino acid sequence of the first 217 residues of mouse heavy chain immunocytochemistry, 4050 (MOPC 47A) with a domain deletion, 2465 Immunodeficiency Immunoglobulin light chain Antibody affinity enhanced in sublethally irradiated mice and bone Amino-acid sequence of NH2-terminal extra piece segments of precursors marrow chimeras, 707 of mouse immunoglobulin Xi-type and K-type light chains, 716 Lymphospecific toxicity in adenosine deaminase deficiency and purine Independent expression of gene coding for constant domain of nlucleoside phosphorylase deficiency: Role of nucleoside kinase(s), 5677 immunoglobulin light chain: Sequence analyses of precursor of Immunodiffusion constant region polypeptide, 3157 3-Hydroxy-3-methylglutaryl-coenzyme A reductase purified from rat Immunoglobulin MOPC 460 liver, 1431 Kinetic evidence for hapten-indtuced conformational transition in Immunofluorescence immunoglobulin MOPC 460 (correction), 1301 Antibody-induced linkages of plasma membrane proteins to intracellular Immunohistochemistry actomyosin-containing filaments in cultured fibroblasts, 5584 Immunohistochemical analysis of peptide pathways possibly related to( Antigenic crossreactivity to RD114 p30 protein, expressed in a human pain and analgesia: Enkephalin and substance P, 3081 fibrosarcoma cell line, 744 Immunohistochemical localization in rabbit brain of a peptide Cell surface-associated structural proteins in connective tissue cells, 2480 resembling COOH-terminal octapeptide of cholecystokinin, 3033 I)efective organization of actin in cultured skin fibroblasts from patients Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic with inherited adenocarcinoma, 3019 GMP in rat renal cortex: Effect of parathyroid hormone, 3569 Dynein identified as outer arms of sea urchin sperm axonemes, 5006 Serotonergic neurons in peripheral nervous system: Identification in gut Filaments 7-10 nm thick visualized in cultured cells of an epithelioid line by immunohistochemical localization of tryptophan hydroxylase, 3086 (Pt K2) by immunofluorescence microscopy, 2490 Immunologic crossreactivity Gene fusions used to study outer membrane protein localization in Antigenic relatedness of DNA polymerase of human breast cancer Escherichia coli, 5411 particles to enzyme of Mason-Pfizer monkey virus, 2144 Hepatic nuclear guanylate cyclase: Regulation, 946 Immunoprecipitation Immunocytochemical identification of substance P cells and their Cell-free translation of simian virus 40 early messenger RNA coding f'or processes in rat sensory ganglia and their terminals in spinal cord: viral T-antigen, 457 Light microscopic studies, 3597 Chemical characterization of murine Ia alloantigens determined by Immunofluorescent staining of cytoplasmic and spindle microtubules in I-E/I-C subregions of H-2 complex, 5131 mouse fibroblasts with antibody to T protein, 2437 Chromosomal location of structural gene f'or RNA polymerase a factor in Localization of RNA polymerase in polytene chromosomes of Drosophila Escherichia coli, 1831 nmelanogaster, 2079 Common precursor to corticotropiins and endorphins, 3014 Mobility and distribution of a cell surface glycoprotein and its Common precursor to corticotropin and /-lipotropin: Cell-free synthesis interaction with other membrane components, 2909 of precursor and identification of corticotropin peptides in the Neurotensin: Immunohistochemical localization in rat central nervous molecule, 4826 system, 4059 Common precursor to corticotropin and /-lipotropin: Identification of Neurotensin: Immunohistochemical localization in rat central nervous /1-lipotropin peptides and their arrangement relative to corticotropin system (correction), 5777 in precursor synthesized in cell-free system, 5300 Opioid peptide enkephalin: Immunohistochemical mapping in rat central Glucocorticoid effect on level of corticotropin messenger RNA activity in nervous system, 2167 rat pituitary, 3283 Phalloidin-induced actin polymerization in cytoplasm of cultured cells HLA-D associated alloantisera react with molecules similar to Ia interferes with cell locomotion and growth, 5613 antigens, 3533 Surface differentiation antigens of human mammary epthelial cells Ia antigens derived from murine thymocytes: Partial chemical carried on human milk fat globule, 582 characterization, 1195 Terminal deoxynucleotidyl transferase in thymocytes demonstrated by Identification of Rauscher murine leukemia virus-specific mRNAs for immunofluorescence, 734 synthesis of gag- and env-gene products, 1855 Terminal deoxynucleotidyltransferase: Intracellular distribution in rat Identification of simian virus 40 tumor and U antigens, 447 bone marrow and thymus, 3993 In vitro synthesis and processing of a putative precursor for the small Transf'ormation by simian virus 40 induces virus-specific, related subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas antigens in surface membrane and nuclear envelope, 2495 reinhardtii, 1082 Transient induction of nuclear antigen unrelated to Epstein-Barr Molecular hybridization used to purify and analyze albumin messenger nuclear antigen in cells of two humano B-lymphoma lines converted by RNA from rat liver, 4346 Epstein-Barr virus, 363 Pregrowth hormone messenger RNA: Glucocorticoid induction and Tlransitions in collagen types during matrix-induced cartilage, bone, and identification in rat pituitary cells, 2357 bone marrow formation, 5589 Structure of murine Ia antigens: Partial NH2-terminal amino-acid Immunoglobulin sequences of products of I-E or I-C subregion, 5135 Antigen-binding mutants of mouse myeloma cells, 5687 Virion polypeptides identified in hamster cells transformed by herpes Cloning of immunoglobulin variable region gene from mouse embryo, simplex virus type 1, 372 3518 Immunopurification Conversion of incomplete antibodies to direct agglutinins by mild Tryptic peptide analysis of normal and mutant forms of hypoxanthine reduction: Segmental flexibility within Fc fragment of phosphoribosyltransferase from HeLa cells, 926 immunoglobulin fG,2531 Immunoregulation Crystallographic studies of bovine /2-microglobulin, 3345 Idiotypic regulation of immune system by induction of antibodies against anti-idiotypic antibodies, 5126 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5821

Suppression of immunoglobulin synthesis and secretion by peripheral Effects of thyrotropin on thyroid cell membrane: Hyperpolarization blood lymphocytes from normal donors, 2099 induced by hormone-receptor interaction, 2352 Immunosuppression Enucleation and reconstruction of interferon-producing cells, 3391 Human a-fetoprotein: Postsynthetic modification controls its Induction and decay of human fibroblast interferon mRNA, 4415 immunosuppressive potency, 3988 Inhibition by anti-interferon serum of lymphocytic choriomeningitis In vitro evidence of cell-mediated immunity after exposure of mice to virus disease in suckling mice, 2135 live and inactivated rabies virus, 334 Inhibition of transcription and translation of globin messenger RNA in Systemic alteration induced in mice by ultraviolet light irradiation and dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated its relationship to ultraviolet carcinogenesis, 1688 with interferon, 2036 Immunosurveillance Interferon messenger RNA content of human fibroblasts during Feline oncornavirus-associated cell-membrane antigen (FOCMA): induction, shutoff, and superinduction of interferon production, 3409 Distinction between FOCMA and the major virion glycoprotein, 1219 Interferon production and interferon messenger RNA synthesis in Indigofera endecaphylla human fibroblasts, 1483 3-Nitropropionate, the toxic substance of Indigofera, is a suicide Physiological regulation of antigen binding to T cells: Role of soluble inactivator of succinate dehydrogenase, 3767 macrophage factor and of interferon, 5662 Indomethacin Retinoic acid (vitamin A acid) induced transcriptional control of Prostaglandin regulation of macrophage collagenase production, 4955 interferon production, 5382 Influenza virus Size and charge heterogeneities of human leukocyte interferons Antibodies against influenza virus produced by somatic cell hybrids eliminated by chemical cleavage, 4200 between mouse myeloma and primed spleen cells, 2985 Synthesis of human interferon by Xenopus laevis oocytes: Two Heterogeneity of cytotoxic response of thymus-derived lymphocytes after structural genes for interferons in human cells, 3287 immunization with influenza viruses, 1209 Variation in ability of measles virus plaque progeny to induce interferon, Specificity studies on cytotoxic thymus-derived lymphocytes reactive 3056 with influenza virus-infected cells: Dual recognition of H-2 and viral Internal degrees of freedom hemagglutinin antigens, 3006 Random walks and generalized master equations with internal degrees of Infrared spectrum freedom, 430 Oxygen intermediates and mixed valence states of cytochrome oxidase: Intestine Infrared absorption difference spectra of compounds A, B, and C of Collagen degradation in rat skin but not in intestine during rapid cytochrome oxidase and oxygen, 4777 growth: Effect on collagen types I and III from skin, 1436 Initiation Intestine as a source of apolipoprotein Al, 2569 Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins Intracellular pH in initiation complexes, 4288 31p nuclear magnetic resonance studies of Ehrlich ascites tumor cells, 87 Initiation factor Ion conductance 3':5'-Cyclic-AMP-dependent protein kinase in regulation of protein Perhydrohistrionicotoxin: Potential ligand for ion conductance synthesis in reticulocyte lysates, 1463 modulator of acetylcholine receptor, 2172 Peptide initiation: Partial reaction inhibited by phosphorylation of Ionic crystal either initiation factor eIF-2 or 40S ribosomal proteins, 1445 Electromagnetism and gravitation, 2664 Rat liver factor that inhibits initiation of protein synthesis in rabbit Ionic permeability reticulocyte lysates, 2264 Hemolysis of human erythrocytes by transient electric field, 1923 Specialized transducing phage for initiation factor 3 gene in Escherichia Ion, lipophilic coli, 3970 Effects of thyrotropin on thyroid cell membrane: Hyperpolarization Unwinding protein specific for mRNA translation fractionated together induced by hormone-receptor interaction, 2352 with rabbit reticulocyte initiation factor 3 complex, 2325 Ion migration Insertion sequence 2 Kinetic polarization deficiency in electrolyte solutions, 401 Excision of F plasmid sequences by recombination at directly repeated Ionophore insertion sequence 2 elements: Involvement of recA, 3965 Biogenic amine-ionophore interactions: Structure and dynamics of Instanton lasalocid (X537A) complexes with phenethylamines and Deformations of instantons, 2662 catecholamines in nonpolar solution, 4734 Insulin Calcium dependence of glucocorticoid-induced lymphocytolysis, 638 see also Preproinsulin Coupling in cytochrome c oxidase, 3662 Alterations in insulin binding accompanying differentiation of 3T3-LI Electrogenic K+/Ca2+ ionophore isolated from an ionophoroprotein of preadipocytes, 4876 beef heart mitochondria, 3667 Amino-terminal sequences of two polypeptides from human serum with Free calcium increases explosively in activating medaka eggs, 623 nonsuppressible insulin-like and cell-growth-promoting activities: Ionic requirements for induction of maturation (meiosis) in full-grown Structural homology with insulin B chain (correction), 1301 and medium-sized Xenopus laevis oocytes, 3461 Angiotensin stimulation of bovine adrenocortical cell growth, 5569 lonophores stimulate prostaglandin and thromboxane biosynthesis, 4251 Biotinylinsulins as potential tools for receptor studies, 2697 lonophores stimulate prostaglandin and thromboxane biosynthesis Cellular uptake and nuclear binding of insulin in human cultured (correction), 5778 lymphocytes: Potential intracellular sites of insulin action, 1368 Oligomycin-dependent ionophoric protein subunit of mitochondrial Effect of uridine on cellular UTP and glycogen synthesis in skeletal adenosinetriphosphatase, 4306 muscle: Stimulation of UTP formation by insulin, 2339 Precursor role of arachidonic acid in release of slow reacting substance Glucose homeostasis during prolonged suppression of glucagon and from rat basophilic leukemia cells, 4577 insulin secretion by somatostatin, 348 Protonmotive force drives bacterial flagella, 3060 Pancreatic immunoreactive somatostatin release, 2140 Uncouplers and molecular mechanism of uncoupling in mitochondria, Polypeptide hormone binding sites in vivo: Initial localization of 2241 125I-labeled insulin to hepatocyte plasmalemma visualized by electron Iron microscope radioautography, 5051 Bonding of FeO2 in hemoglobin and related dioxygen complexes, 1780 Serum sex hormones and glucose, insulin, and lipid abnormalities in men Excited state lifetimes in cytochromes measured from Raman scattering with myocardial infarction, 1729 data: Iron-porphyrin interactions, 2607 Temporal sequence of hormonal interactions during prereplicative phase Oxyhemoglobin: Magnetic properties and structure, 2612 of quiescent cultured 3T3 fibroblasts, 3845 Picosecond dynamics of iron proteins, 4139 Transplantable insulinoma in rat, 628 Rates of dissolution of Fe4S4 clusters of Chromatium vinosum Insulin-like activity high-potential iron protein and ferredoxin depend on cluster oxidation Amino-terminal sequences of two polypeptides from human serum with state, 5231 nonsuppressible insulin-like and cell-growth-promoting activities: Surface, catalytic, and magnetic properties of small iron particles: Effect Structural homology with insulin B chain (correction), 1301 of chemisorption of hydrogen on magnetic anisotropy, 806 Insulinoma Iron-molybdenum cofactor Transplantable insulinoma in rat, 628 Isolation of iron-molybdenum cofactor from nitrogenase, 3249 Insulitis Iron-sulfur protein Streptozotocin-induced insulitis and diabetes, 2485 Electron paramagnetic resonance studies of photosynthetic electron Integer programming transport: Photoreduction of ferredoxin and membrane-bound Structure of production sets with indivisibilities, 3637 iron-sulfur centers, 3826 Integrability problem Iron-sulfur center identified in trimethylamine dehydrogenase, 547 Class of counterexamples to the integrability problem, 26155 Irradiation Integrals Mutation frequencies in female mice and estimation of genetic hazards Differentiation of integrals, 2211 of radiation in women, 3523 Integumental gland Irradiation,ultraviolet Characterization and synthesis of volatile compounds for defensive Activation of cytotoxic T cells by nonstimulating tumor cells and spleen secretions of "daddy longlegs" (Arachnida: Opiliones: Leiobunum cell factor(s), 4610 spp.), 419 Contacts between lac repressor and thymines in lac operator, 4973 Intercalation Differences in removal of acetylaminofluorene and pyrimidine dimers Sequence specificity of mutagen-nucleic acid complexes ill solution: from DNA of cultured mammalian cells, 1553 Intercalation and mutagen-base pair overlap geometries for proflavine Different rate-limiting steps in excision repair of ultraviolet- and binding of dC-dC-dG-dG and dG-dG-dC-dC self-complementary N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human duplexes, 2624 fibroblasts, 1548 Interferon Evidence from UV transcription mapping in HeLa cells that Binding of mouse interferon to polynucleotides, 3787 heterogeneous nuclear RNA is the messenger RNA precursor, 4520 Downloaded by guest on September 27, 2021 5822 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Genetic evidence for inducibility of recombination competence in yeast, Kinetics, reassociation 1667 Bovine papilloma virus: Virus-specific DNA sequences in naturally Initiation of genetic exchanges in X phage-prophage crosses, 291 occurring equine tumors, 524 Mutant of Escherichia coli showing constitutive expression of lysogenic DNA sequence organization in water mold Achlya, 4332 induction and error-prone DNA repair pathways, 300 Immunologic selection against simian virus-40 transformed cells: Pyrimidine dimers in DNA can give rise to tumors, 5574 Concomitant loss of viral antigens and early viral gene sequences, 4796 Specific action of T4 endonuclease V on damaged DNA in xeroderma Nucleic acid reassociation kinetics: Rate of hybridization of excess RNA pigmentosum cells in vivo, 2958 with DNA, compared to rate of DNA renaturation, 1020 Systemic alteration induced in mice by ultraviolet light irradiation and Nucleic acid reassociation kinetics: Retarded rate of hybridization of its relationship to ultraviolet carcinogenesis, 1688 RNA with excess DNA, 2306 Irradiation, x- Kinetics,renaturation Antibody affinity enhanced in sublethally irradiated mice and bone Cloned segment of Drosophila melanogaster rDNA containing new types marrow chimeras, 707 of sequence insertion, 4932 Genetic evidence for inducibility of recombination competence in yeast, Kininogen,high-molecular-weight 1667 High-molecular-weight kininogen: Role in surface-binding and activation Immunoprevention of x-ray-induced leukemias in C57BL mouse, 1697 of coagulation Factor XI and prekallikrein, 4636 Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to Kirromycin ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 Conformational alteration of protein synthesis elongation factor EF-Tu Irreversible process by EF-Ts and by kirromycin, 3264 Microscopic theory of irreversible processes, 4152 Elongation factor Tu resistant to kirromycin in Escherichia coli mutant Ising problem altered in both tuf genes, 4341 "Virial" expansion of enzyme flux and use of quasi-chemical Klebsiella pneumoniae approximation for two-state enzymes with enzyme-enzyme Enhancement of nonspecific immunity to Klebsiella pneumoniae interactions, 5227 infection by a synthetic immunoadjuvant Ising theory (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs, 2089 Enzyme-enzyme interactions affect steady-state enzyme kinetics, 4111 Recombinant plasmid that carries part of nitrogen fixation (nif) gene Islets of Langerhans cluster of Klebsiella pneumoniae, 2963 Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes, 2059 Streptozotocin-induced insulitis and diabetes, 2485 Lacrimal gland Isoelectric focusing Luminal membrane retrieved after exocytosis reaches most Golgi Actin microheterogeneity in chick embryo fibroblasts, 120 cisternae in secretory cells, 5073 Antigenic distinctions of glycoproteins in plasma and mitochondrial a-Lactalbumin membranes of lymphoid cells neoplastically transformed by simian Cell-surface glycosyltransferases in cultured fibroblasts: Increased virus 40, 643 activity and release during serum stimulation of growth, 1086 Soluble glutathione-dependent d5-3-ketosteroid isomerase and Lactate glutathione S-transferases of liver, 158 Proline oxidase activity regulated by lactate, 5368 Isoenzyme Lactate dehydrogenase(EC 1.1.1.27) see Isozyme Lactate dehydrogenase isozymes: Structural adaptations, 2677 Isoproterenol Lactic acidosis Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic Proline oxidase activity regulated by lactate, 5368 GMP from induction of ornithine decarboxylase by tumor promoter Lactobacilluscasei 12-0-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo, 657 Metabolism of pentitols: New pathway, 4296 Isozyme Lactollin Extension of longevity in Drosophila mojavensis by environmental Crystallographic studies of bovine /2-microglobulin, 3345 ethanol: Differences between subraces, 387 Lagrangemultipliers Genetic control of mitochondrial malate dehydrogenases: Evidence for Convex programs having some linear constraints, 26 duplicated chromosome segments, 310 Lakes Is evolution gradual or rectangular? Evidence from living fishes, 5083 Cyclonic mean circulation of large lakes, 2204 Lactate dehydrogenase isozymes: Structural adaptations, 2677 Lamellarbody Formation of lung surfactant films from intact lamellar bodies, 3617 Lanosterol Joule-heating Cholesterol and lanosterol: Differential effects on artificial membranes, Hemolysis of human erythrocytes by transient electric field, 1923 4924 LasalocidA Biogenic amine-ionophore interactions: Structure and dynamics of Kahler manifold lasalocid (X537A) complexes with phenethylamines and Calabi's conjecture and some new results in algebraic geometry, 1798 catecholamines in nonpolar solution, 4734 Karyoplast Laser Selection of reconstituted cells from karyoplasts fused to Chlorophyll lasers: Stimulated light emission by chlorophylls and chloramphenicol-resistant cytoplasts, 2461 Mg-free chlorophyll derivatives, 5 Kasugamycin Effect of increased potassium concentrations on particle motion within a Ribosome structure: Localization of N6,N6-dimethyladenosine by neurosecretory structure, 5759 electron microscopy of a ribosome-antibody complex, 1468 Kinetics of alkaline tetramer to dimer dissociation in liganded human a-Ketoglutarate dehydrogenase hemoglobin: Laser light-scattering stopped-flow study, 3814 see Oxoglutarate dehydrogenase Nucleic acid components: Ultraviolet resonant Raman spectroscopy, 2639 d5-3-Ketosteroid isomerase Radiationless relaxation in "large" molecules: Preparation of true see Steroid d-isomerase molecular eigenstates and Born-Oppenheimer states by a coherent Kidney light source, 1310 Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic Resonance coherent anti-Stokes Raman scattering spectra of fluorescent GMP in rat renal cortex: Effect of parathyroid hormone, 3569 biological chromophores: Vibrational evidence for hydrogen bonding of' Sugar uptake into brush border vesicles from normal human kidney, flavin to glucose oxidase and for rapid solvent exchange, 4146 2825 Time-resolved resonance Raman spectroscopy of bacteriorhodopsin on Kinase the millisecond timescale, 5212 Phosphorylation of smooth muscle myosin affects actin activation and Laticauda semifasciata Ca2+ regulation, 129 Neurotoxin a from venom of Philippines sea snake: Three-dimensional Kinetic polarization deficiency structure, 971 Kinetic polarization deficiency in electrolyte solutions, 401 Least-squaresestimate Kinetic proofreading Strong consistency of least-squares estimates in regression models, 2667 Kinetic proofreading in aminoacylation of tRNA by synthetase, 2246 Lecithin Kinetics Cholesterol and lanosterol: Differential effects on artificial membranes, see also Enzyme kinetics 4924 Biogenic amine-ionophore interactions: Structure and dynamics of Lecithin bimolecular leaflets: Nuclear magnetic resonance studies with lasalocid (X537A) complexes with phenethylamines and incorporated fluorescent probes, 1032 catecholamines in nonpolar solution, 4734 Lipid-protein interaction in phosphatidylcholine exchange protein, 1807 Time-resolved resonance Raman spectroscopy of bacteriorhodopsin on Lectin the millisecond timescale, 5212 see also Concanavalin A; Phytohemagglutinin; Wheat germ agglutinin Kinetics, dissociation Changes in surface properties of normal and transformed cells caused by Kinetics of alkaline tetramer to dimer dissociation in liganded human tunicamycin, inhibitor of protein glycosylation, 3433 hemoglobin: Laser light-scattering stopped-flow study, 3814 Erythropoietin: Isolation by affinity chromatography with lectin-agarose Kinetics, hydrolysis derivatives, 4633 Rates of dissolution of Fe4S4 clusters of Chromatium vinosum Isolation and characterization of muscle membranes using high-potential iron protein and ferredoxin depend on cluster oxidation surface-specific labels, 34 state, 5231 Leiobunum Kinetics, irreversible Characterization and synthesis of volatile compounds for defensive Calcium-induced luminescence of aequorin: Reversible and irreversible secretions of "daddy longlegs" (Arachnida: Opiliones: Leiobunum inhibition by anesthetics, 5534 spp.), 419 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5823

Lens Ligandin Lens ac-crystallin 14S mRNA: Bicistronic nature, 5448 see Glutathione S-transferase B Lesch-Nyhan disease Linearconstraint Mosaic mice with teratocarcinoma-derived mutant cells deficient in Convex programs having some linear constraints, 26 hypoxanthine phosphoribosyltransferase, 5564 Linearization Leucophaeamaderae Hyperbolic almost periodic solutions and toroidal limit sets, 3124 Mutual entrainment of bilaterally distributed circadian pacemakers, Linkage disequilibrium 1277 Mechanism of genetic coadaptation in populations of Drosophila Leucyl-tRNAsynthetase (EC 6.1.1.4) melanogaster, 324 see also Aminoacyl tRNA synthetases Lipase Involvement of an internal promoter in regulation and synthesis of Activation of hormone-sensitive lipase and phosphorylase kinase by mitochondrial and cytoplasmic leucyl-tRNA synthetases of purified cyclic GMP-dependent protein kinase, 4843 Neurospora, 1172 Lipid Leukemia see also Membrane lipid; Oligosaccharide-lipid Antibody to autologous human leukemia cells detected by immune Comparative rates of transfer of lipid-linked oligosaccharides to adherence assays, 4587 endogenous glycoprotein acceptors in vitro, 4411 Expression of Ia-like antigen molecules on human granulocytes during Deuterium magnetic resonance studies of interaction of lipids with early phases of differentiation, 4012 membrane proteins, 5435 Immunoprevention of x-ray-induced leukemias in C57BL mouse, 1697 Lipid-protein interaction in phosphatidylcholine exchange protein, 1807 Rauscher-leukemia-virus-related sequences in human DNA: Presence in Regenerated endothelium affects lipid accumulation in arterial wall, 1724 some tissues of some patients with hematopoietic neoplasias and Serum sex hormones and glucose, insulin, and lipid abnormalities in men absence in DNA from other tissues, 353 with myocardial infarction, 1729 Leukemia,myeloid Lipid bilayer Chromosome mapping of genes that control differentiation and Glycophorin and the concanavalin A receptor of human erythrocytes: malignancy in myeloid leukemic cells, 253 Receptor function in lipid bilayers, 2751 Leukemiavirus, avian Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in RNA of avian acute leukemia virus MC29, 4320 liposomes, 1580 Leukemiavirus, feline Nuclear magnetic resonance studies of interaction of general anesthetics Feline oncornavirus-associated cell-membrane antigen (FOCMA): with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer Distinction between FOCMA and the major'virion glycoprotein, 1219 (correction), 3621 Feline oncornavirus-associated cell membrane antigen: Immunologically Lipid solubility crossreactive feline sarcoma virus-coded protein, 5608 Food, drug, and cosmetic dyes: Biological effects related to lipid Leukemiavirus, Friend solubility, 2914 Cellular mRNA degraded during infection by herpes simplex virus, 2370 Lipid vesicle Spectrin induced in erythroleukemic cells transformed by Friend virus, Biological properties of poliovirus encapsulated in lipid vesicles: 3898 Antibody resistance and infectivity in virus-resistant cells, 3471 Leukemiavirus, Moloney Lipid vesicles in vivo: Gamma-ray perturbed angular correlation study, Moloney leukemia virus-induced cell surface antigen: Detection and 4991 characterization in sodium dodecyl sulfate gels, 5270 Liposome-lymphocyte interaction: Saturable sites for transfer and Leukemiavirus, murine intracellular release of liposome contents, 5603 Friend strain of spleen focus-forming virus is recombinant between Lipopolysaccharide ecotropic murine type C virus and env gene region of xenotropic type Domains involving nonrandom distribution of lipopolysaccharide in C virus, 4671 outer membrane of Escherichia coli, 5065 Humoral immune response of NIH Swiss and SWR/J mice to vaccination Lipoprotein with formalinized AKR or Gross murine leukemia virus, 343 see also Apolipoprotein Immunoprevention of x-ray-induced leukemias in C57BL mouse, 1697 Activation of lipoprotein lipase by native and synthetic fragments of MCF murine leukemia viruses are envelope (env) gene recombinants: human plasma apolipoprotein C-II, 4848 Biochemical evidence, 4676 Amino acid sequence for peptide extension on prolipoprotein of Murine leukemia virus associated with development of spontaneous Escherichia coli outer membrane, 1004 lymphomas, 789 Antigen-specific nonimmunoglobulin factor that neutralizes xenotropic Segregation of genetic information for a B-tropic leukemia virus with the virus is associated with mouse serum lipoproteins, 276 structural locus for BALB:virus-1, 2953 Biochemical characterization of mutant lipoprotein of Escherichia coli, Transforming murine leukemia viruses isolated from mice with a high 1388 incidence of spontaneous lymphoma, 3065 Biosynthesis of covalently linked diglyceride in murein lipoprotein of Leukemiavirus, Rauscher Escherichia coli, 5318 Identification of Rauscher murine leukemia virus-specific mRNAs for Cellular division in Escherichia coli: Mutant of E. coli lacking a synthesis of gag- and env-gene products, 1855 murein-lipoprotein, 1417 Murine leukemia virus morphogenesis: Cleavage of P70 ir vitro can be Primary structure of very low density apolipoprotein C-II of human accompanied by shift from concentrically coiled internal strand plasma, 1942 ("immature") to collapsed ("mature") form of virus core, 3446 Structure of human serum lipoproteins inferred from compositional Partial inhibition of postreplication repair and enhanced frequency of analysis, 837 chemical transformation in rat cells infected with leukemia virus, 238 Lipoprotein,high density Rauscher-leukemia-virus-related sequences in human DNA: Presence in Amyloid protein SAA is associated with high density lipoprotein from some tissues of some patients with hematopoietic neoplasias and human serum, 4025 absence in DNA from other tissues, 353 Electron microscopy of negatively stained and freeze-etched high density Leukocyte lipoprotein-3 from human serum, 5001 Colchicine affects cyclic AMP levels in human leukocytes, 3404 Interaction of L-a-didecanoyl phosphatidylcholine with Al polypeptide Low-molecular-weight peptide inhibits RNA synthesis in human of high density lipoprotein, 3796 leukemic and phytohemagglutinin-stimulated leukocytes and globin Intestine as a source of apolipoprotein A1, 2569 mRNA transcription in differentiating Friend cells, 3869 Lipoproteinlipase Specific receptor sites for chemotactic peptides on human see also Triacylglycerol lipase polymorphonuclear leukocytes, 1204 Primary structure of very low density apolipoprotein C-II of human Leupeptin plasma, 1942 Antipain and leupeptin restrict uterine DNA synthesis and function in Lipoprotein,low density mice, 3754 Cholesterol synthesis in rat adrenal gland regulated through coordinate Levodopa control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and see L-Dopa reductase activities, 1421 Lie algebra Solubilization of apolipoprotein B and its specific binding by cellular see also Semisimple Lie group receptor for low density lipoprotein, 5150 Classification of irreducible representations of semisimple Lie groups, Structure of human plasma low-density lipoproteins: Molecular 2649 organization of central core, 1042 Class of counterexamples to the integrability problem, 2655 Liposome Life C-reactive protein and complement interact with liposomes, 5672 Living state and cancer, 2844 Isolation of chloroplast N,N'-dicyclohexylcarbodiimide-binding Ligand proteolipid, active in proton translocation, 2375 see also Cholinergic ligand Lipid vesicles in vivo: Gamma-ray perturbed angular correlation study, Ligand-promoted weakening of intersubunit bonding domains in 4991 aspartate transcarbamoylase, 3777 Liposome-lymphocyte interaction: Saturable sites for transfer and Ligand,bimetallic intracellular release of liposome contents, 5603 Synthesis and characterization of "face-to-face" porphyrins, 18 Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in Ligandbinding liposomes, 1580 Analytical and graphical examination of strong binding by half-of-sites Proton spin-lattice relaxation of retinal rod outer segmnentmembranes in proteins: Illustration with aspartate transcarbamylase, 4959 and liposomes of extracted phospholipids, 1978 Distinctions between two-state and sequential models for cooperative ,-Lipotropin ligand binding, 139 see also /-Endorphin Transmembrane interactions and mechanism of capping of surface Common precursor to corticotropins and endorphins, 3014 receptors by their specific ligands, 5031 Common precursor to corticotropin and /-lipotropin: Cell-free synthesis Downloaded by guest on September 27, 2021 5824 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

of precursor and identification of corticotropin peptides in the Lymphocyte molecule, 4826 see also Cell, B; Cell, T Common precursor to corticotropin and /-lipotropin: Identification of Activation of cytotoxic T cells by nonstimulating tumor cells and spleen /-lipotropin peptides and their arrangement relative to corticotropin cell factor(s), 4610 in precursor synthesized in cell-free system, 5300 Calcium dependence of glucocorticoid-induced lymphocytolysis, 638 Conformation of /-endorphin and f-lipotropin: Formation of helical Cellular uptake and nuclear binding of insulin in human cultured structure in methanol and sodium dodecyl sulfate solutions, 3235 lymphocytes: Potential intracellular sites of insulin action, 1368 /-Endorphin: In vitro biosynthesis in pituitary glands, 1403 Characterization of an erythroid precursor cell of high proliferative In vitro biosynthesis of /-endorphin, -y-lipotropin, and /-lipotropin by capacity in normal human peripheral blood, 1105 pars intermedia of beef pituitary glands, 4276 Gyrate atrophy of choroid and retina: Deficiency of ornithine Isolation and characterization of opioid peptides from rat pituitary: aminotransferase in transformed lymphocytes, 5159 /1-Lipotropin, 3052 Host-determined differences in expression of surface marker /-Lipotropin: Localization of cells and axons in rat brain by characteristics on human and simian lymphoblastoid cell lines immunocytochemistry, 5155 transformed by Epstein-Barr virus, 749 Opiate peptides synthesized by a clonal pituitary tumor cell line, 2259 Kinetics of cell death and disintegration in human lymphocyte cultures, "y-Lipotropin 2536 In vitro biosynthesis of /-endorphin, -y-lipotropin, and /-lipotropin by Ligand-independent cap formation: Redistribution of surface receptors pars intermedia of beef pituitary glands, 4276 on mouse lymphocytes and thymocytes in hypertonic medium, 4511 Lipoxidase Liposome-lymphocyte interaction: Saturable sites for transfer and Human platelet guanylate cyclase stimulated by unsaturated fatty acid intracellular release of liposome contents, 5603 peroxides, 3657 Lymphocyte alloantigens associated with X-chromosome-linked immune Lipschitz curve response genes, 721 Cauchy integrals on Lipschitz curves and related operators, 1324 Lymphocyte mitogenesis induced by mammalian liver protein that Liquid specifically binds desialylated glycoproteins, 676 Significant structure theory applied to phase separation, 10 Lymphospecific toxicity in adenosine deaminase deficiency and purine Significant structure theory applied to liquid helium-3, 4739 nucleoside phosphorylase deficiency: Role of nucleoside kinase(s), 5677 Single partition function for three phases, 2598 Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by Listeria monocytogenes its effects on cell membrane (correction), 392 Secretion of mediators following T lymphocyte-macrophage interaction Regulation of cholesterol biosynthesis by normal and leukemic (L2C) is regulated by major histocompatibility complex, 3542 guinea pig lymphocytes, 956 Lithium Solubilization of apolipoprotein B and its specific binding by cellular see also Transport, lithium receptor for low density lipoprotein, 5150 Lithium efflux through Na/K pump in human erythrocytes, 3099 Suppression of immunoglobulin synthesis and secretion by peripheral Liver blood lymphocytes from normal donors, 2099 see also Cell, liver Terminal deoxynucleotidyl transferase in thymocytes demonstrated by Combined use of fetal liver and thymus for immunological reconstitution immunofluorescence, 734 in patients with variants of severe combined immunodeficiency, 3002 Tritium suicide selection of mammalian cell mutants defective in Coordination of ribosome content and polysome formation during transport of neutral amino acids, 4549 estradiol stimulation of vitellogenin synthesis in immature male chick Lymphocytic choriomeningitis virus livers, 31.33 Inhibition by anti-interferon serum of lymphocytic choriomeningitis Electron spin resonance absorption of tissue constituents, 1558 virus disease in suckling mice, 2135 Evidence against phospholipid asymmetry in intracellular membranes Lymphoma from liver, 3350 Adenylate cyclase permanently uncoupled from hormone receptors in Fatty liver induced in Zucker "fatty" (f/) rats by semisynthetic diet rich novel variant of S49 mouse lymphoma cells, 2016 in sucrose, 3038 Direct demonstration of mturine thymus-dependent cell surface Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich endogenous immunoglobulin, 2113 in sucrose (correction), 3550 Murine leukemia virus associated with development of spontaneous Hepatic mitochondrial cytochrome P-450: Isolation and functional lymphomas, 789 characterization, 5477 Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to Isolation of sr-alcohol dehydrogenase of human liver: Determinant of ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 alcoholism? 4378 Reconstitution of catecholamine-sensitive adenylate cyclase activity: Molecular hybridization used to purify and analyze albumin messenger Interaction of solubilized components with receptor-replete RNA from rat liver, 4346 membranes, 3715 Rat liver factor that inhibits initiation of protein synthesis in rabbit Subunit interaction in cyclic AMP-dependent protein kinase of mutant reticulocyte lysates, 2264 lymphoma cells, 1167 Receptor protein of activated carcinogen, 2293 Transforming murine leukemia viruses isolated from mice with a high Role of sialic acid in survival of erythrocytes in circulation: Interaction of incidence of spontaneous lymphoma, 3065 neuraminidase-treated and untreated erythrocytes with spleen and Type C RNA virus isolated from an established human histiocytic liver at cellular level, 1521 lymphoma cell line, 2564 Soluble glutathione-dependent d5-3-ketosteroid isomerase and Lymphoma, Burkitt glutathione S-transferases of liver, 158 Epstein-Barr viral DNAs compared in Burkitt lymphoma biopsy cells Liver disease, chronic and in cells clonally transformed in vitro, 4651 Sex differences in response to hepatitis B infection among patients Intestine as a source of apolipoprotein A1, 2574 receiving chronic dialysis treatment, 2561 Transient induction of nuclear antigen unrelated to Epstein-Barr Longevity nuclear antigen in cells of two human B-lymphoma lines converted by Extension of longevity in Drosophila mojavensis by environmental Epstein-Barr virus, 363 ethanol: Differences between subraces, 387 D-Lysergic acid diethylamide Luciferase Antagonism of histamine-activated adenylate cyclase in brain by Chemiluminescent reactions and electrophilic oxygen donating ability of D-lysergic acid diethylamide, 5697 4a-hydroperoxyflavins: Preparation of N5-alkyl-1,5-dihydroflavins, 405 Lysine Source of oxygen in C02 produced in bioluminescent oxidation of firefly Specific lysine labeling by 18OH- during alkaline cleavage of luciferin, 2799 r-l-antitrypsin-trypsin complex, 4311 Luciferin Lysolecithin Source of oxygen in CO2 produced in bioluminescent oxidation of firefly Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in luciferin, 2799 liposomes, 1580 Structure of native Renilla reniformis luciferin, 4285 Lysosomal storage disease Luminescence Mannosidosis: Assignment of lysosomal r(-mannosidase B gene to see also Chemiluminescence chromosome 19 in man, 2968 Calcium-induced luminescence of aequorin: Reversible and irreversible Lysosome inhibition by anesthetics, 5534 Phosphohexosyl components of a lysosomal enzyme are recognized by Source of oxygen in CO2 produced in bioluminescent oxidation of firefly pinocytosis receptors on human fibroblasts, 2026 luciferin, 2799 Soluble ATP-dependent proteolytic system responsible for degradation Lung of abnormal proteins in reticulocytes, 54 Forrnation of lung surfactant films from intact lamellar bodies, 3617 Lysozyme Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin Genetic dissection of control of normal differentiation in myeloid methyl ester: Comparison with endoperoxides and other prostanoids, leukemic cells, 5554 5711 Lysozyme (EC 3.2.1.17) Luteinizing hormone Enzyme-substrate complexes of lysozyme: Structures, 2629 see Lutropin Formation of four isomers of hen egg white lysozyme containing three Lutropin native disulfide bonds and one open disulfide bond, 2362 Gonadotropin-induced regulation of luteinizing hormone receptors and Lysyl oxidase desensitization of testicular 3':5'-cyclic AMP and testosterone Reduction of blood pressure and vascular collagen in hypertensive rats responses, 592 by /-aminopropionitrile, 360 Ovarian "inhibin": Suppression of secondary rise in serum follicle Lytechinus pictus stimulating hormone levels in proestrous rats by injection of porcine Cytoplasmic nonpolysomal ribonucleoprotein particles in sea urchin follicular fluid, 572] embryos and their relationship to protein synthesis, 2231 Oligouridylate stretches in heterogeneous nuclear RNA, 2217 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5825

MacMahon'sconjecture a-Mannosidase MacMahon's conjecture on symmetric plane partitions, 426 Transfer of mannose from mannosyl retinyl phosphate to protein, 3762 Macromolecule a-Mannosidase(EC 3.2.1.24) Existence of a steady state in a biological system, 4182 Mannosidosis: Assignment of lysosomal a-mannosidase B gene to Macrophage chromosome 19 in man, 2968 Antigenic complex recognized by T lymphocytes: Specific sensitization Mannosidosis by antigens associated with allogeneic macrophages, 2104 Mannosidosis: Assignment of lysosomal a-mannosidase B gene to Endocytosis: Response to altered fatty acyl composition of macrophage chromosome 19 in man, 2968 phospholipids, 4895 Mannosylretinyl phosphate Genetic dissection of control of normal differentiation in myeloid Transfer of mannose from mannosyl retinyl phosphate to protein, 3762 leukemic cells, 5554 Markovchain Macrophage migration inhibitory activity generated by plasminogen Nonidentifiability in stochastic models of illness and death, 1338 activators, 1570 Martingale Prostaglandin regulation of macrophage collagenase production, 4955 Strong consistency of least-squares estimates in regression models, 2667 Secretion of mediators following T lymphocyte-macrophage interaction Mason-Pfizermonkey virus is regulated by major histocompatibility complex, 3542 Antigenic relatedness of DNA polymerase of human breast cancer Unprimed spleen cell populations recognize macrophage-bound antigen particles to enzyme of Mason-Pfizer monkey virus, 2144 with opposite net electric charge, 1693 Endogenous new world primate retrovirus: Interspecies antigenic Macrophagefactor determinants shared with major structural protein of type-D RNA Physiological regulation of antigen binding to T cells: Role of soluble viruses of old world monkeys, 5734 macrophage factor and of interferon, 5662 Evolution of primate oncornaviruses: Endogenous virus from langurs MagellanicCloud (Presbytis spp.) with related virogene sequences in other Old World Chemical compositions of Magellanic Clouds' HII regions based on monkeys, 4557 photoelectric spectrophotometry, 5203 Interspecies radioimmunoassay for major structural proteins of primate Magnesium type-D retroviruses, 5739 Activation of cardiac adenylate cyclase: Hormonal modification of Mass spectrometry magnesium ion requirement, 92 5-Methylcytosine in chromatin, 2725 Binding of Zn2+ to rat liver fructose-1,6-bisphosphatase and its effect on Mathematics catalytic properties, 2742 see also Applied Mathematical Sciences; Applied Physical and In vitro assembly of pure tubulin into microtubules in absence of Mathematical Sciences microtubule-associated proteins and glycerol, 1860 Analytic torsion and Reidemeister torsion, 2651 Ionic requirements for induction of maturation (meiosis) in full-grown Calabi's conjecture and some new results in algebraic geometry, 1798 and medium-sized Xenopus laevis oocytes, 3461 Cauchy integrals on Lipschitz curves and related operators, 1324 Magnesium and calcium effects on uptake of hexoses and uridine by Classification of irreducible representations of semisimple Lie groups, chick embryo fibroblasts, 1585 2649 31p nuclear magnetic relaxation studies of phosphocreatine in intact Class of counterexamples to the integrability problem, 2655 muscle: Determination of intracellular free magnesium, 4271 Complexsubmanifolds in real-analyticpseudoconvex hypersurfaces, 3126 Magneticanisotropy Convex programs having some linear constraints, 26 Surface, catalytic, and magnetic properties of small iron particles: Effect Deformations of instantons, 2662 of chemisorption of hydrogen on magnetic anisotropy, 806 Differentiation of integrals, 2211 Magneticfield Equivalence between boundedness of certain classes of maximal and Transient magnetic effects in scale model of earth's core, 4744 multiplier operators in Fourier analysis, 423 Magnetic susceptibility Explicit Plancherel theorem for ground state representation of Kinetics of hemoglobin-carbon monoxide reactions measured with a Heisenberg chain, 816 superconducting magnetometer: Method for fast reactions in solution, Extended Watson integrals for cubic lattices, 1800 2620 Fourier analysis on the Heisenberg group, 1328 Magneticsuspension Hyperbolic almost periodic solutions and toroidal limit sets, 3124 Simultaneous measurements of viscosity and density in solutions MacMahon's conjecture on symmetric plane partitions, 426 undergoing change, 4430 Pseudo-monotone operators and nonlinear elliptic boundary value Magnetohydrodynamics problems on unbounded domains, 2659 Method of computational magnetohydrodynamics defining stable Scyllac Reducibility criterion for generalized principal series, 5252 equilibria, 393 Restrictions on coefficients of hyperbolic systems of partial differential Maize equations, 4150 see Zea mays Sharpened form of Schauder fixed-point theorem, 4749 Majorhistocompatibility complex Structure of production sets with indivisibilities, 3637 see also Antigen, histocompatibility; Histocompatibility complex Sufficient conditions for subellipticity on weakly pseudo-convex Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator domains, 2214 cells crossreact with chemically modified syngeneic cells, 1229 Theorems of Barth-Lefschetz type for complex subspaces of Major histocompatibility complex assigned to a region of the short arm homogeneous complex manifolds, 1332 of human chromosome 6, 1147 Tubular presentations 7rof subsets of manifolds, 2209 Major histocompatibility complex assigned to a region of the short arm Mating system of human chromosome 6 (correction), 5776 Parental investment, mate choice, and mate quality, 3476 Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator Maturation cells exhibit specificity for H-2 complex alloantigens, 4572 Size-mediated onset of genetically determined maturation in platyfish, Physiological regulation of antigen binding to T cells: Role of soluble Xiphophorus maculatus, 4547 macrophage factor and of interferon, 5662 Measlesvirus Potentiation of primary in vivo antibody response by alloantisera against Variation in ability of measles virus plaque progeny to induce interferon, gene products of I region of H-2 complex, 3975 3056 Secretion of mediators following T lymphocyte-macrophage interaction Mechanoreceptor is regulated by major histocompatibility complex, 3542 Cilia: Active role in sensory transduction, 793 Specificity studies on cytotoxic thymus-derived lymphocytes reactive Medaka with influenza virus-infected cells: Dual recognition of H-2 and viral see Oryzias latipes hemagglutinin antigens, 3006 Mediator Structural heterogeneity of C2 complement protein and its genetic Secretion of mediators following T lymphocyte-macrophage interaction variants in man: New polymorphism of HLA region, 1672 is regulated by major histocompatibility complex, 3542 Malate dehydrogenase (EC 1.1.1.37) Meiosis Genetic control of mitochondrial malate dehydrogenases: Evidence for Changes in pattern of protein synthesis during meiotic maturation of duplicated chromosome segments, 310 mammalian oocytes in vitro, 538 Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, Developmental defects associated with glucosamine auxotropy in 2514 Saccharomyces cerevisiae, 4351 Malthusian parameter Ionic requirements for induction of maturation (meiosis) in full-grown Measures of fitness and demographic stability, 384 and medium-sized Xenopus laevis oocytes, 3461 Mammarygland Role of mitotic replication genes in chromosome duplication during Hormonal effects on intracellular and secreted casein in cultures of meiosis, 3951 mouse mammary epithelial cells on floating collagen membranes, 4466 Melanocytestimulating hormone Hormone-inducible casein messenger RNA in serum-free organ culture see Melanotropin of whole mammary gland, 2441 Melanoplus bivittatus Manic depression Cilia: Active role in sensory transduction, 793 Abnormal lithium and sodium transport in erythrocytes of manic patient ,-Melanotropin and some members of his family, 3607 Common precursor to corticotropins and endorphins, 3014 Lithium efflux through Na/K pump in human erythrocytes, 3099 Corticotropin in brain of normal and hypophysectomized rats, 648 Manifold Number of receptors for /-melanocyte stimulating hormone in Cloudman Tubular presentations or of subsets of manifolds, 2209 melanoma cells is increased by dibutyryl adenosine 3':5'-cyclic Mannoprotein monophosphate or cholera toxin, 601 Developmental defects associated with glucosamine auxotropy in Melittin Saccharomyces cerevisiae, 4351 Translation of melittin messenger RNA in uitro yields a product Mannose terminating with glutaminylglycine rather than with glutaminamide, Transfer of mannose from mannosyl retinyl phosphate to protein, 3762 975 Downloaded by guest on September 27, 2021 5826 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Membrane Membrane-controlled depletion of complement activity by see also Receptor, membrane spin-label-specific IgM, 3537 Membrane, artificial Microviscosity modulation during cell cycle of ineuroblastoma cells, 4458 Cholesterol and lanosterol: Differential effects on artificial membranes, Membrane fusion 4924 Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in Membrane assembly liposomes, 1580 Membrane assembly in vitro: Synthesis, glycosylation, and asymmetric Membrane ultrastructural changes durirngcalcium phosphate-inlducerd insertion of transmembrane protein, 3278 fusion of human erythrocyte ghosts, 2417 Membrane, axonal Membrane lipid Density of sodium channels in mammalian myelinated nerve fibers and Lipid and protein segregation in Escherichia coli membrane: nature of axonal membrane under myelin sheath, 211 Morphological and structural study of different cytoplasmic membrane Membrane, bacterial fractions, 452 Affinity of intact Escherichia coli for hydrophobic membrane probes is a Sendai virus-induced hemolysis: Reduction in heterogeneity of funioctionof the physiological state of cells, 1811 erythrocyte lipid bilayer fluidity, 1918 Amiio acid sequence for peptide extension on prolipoprotein of Membrane, lipid bilayer Escherichia colli outer membrane, 1004 Structure of gramicidin A channel: Discrimination between rI,,D and / Cell-cell interactions in conjugating Escherichia coli: Role of traT helix by electrical measurements with lipid bilayer membranes, 2402 protein in surface exclusion, 51.04 Synthesis of a 19-residue peptide with alamethicin-like activity, 115 D)omains inovolvingnoonrandom distribution of lipopolysaccharide in Membrane, liver outer membrane of Escherichia coli, 5065 Two distinct adenosine-sensitive sites on adeinylate cyclase, 5482 Extracellular labeling of nascent polypeptides traversing the membrane Membrane, luminal of Escherichia coli, 2830 Luminal membrane retrieved after exocytosis reaches most Golgi Lipid and protein segregation in Escherichia coli membrane: cisternae in secretory cells, 5073 Morphological and structural study of different cytoplasmic membrane Membrane, lymphocyte fractions, 452 Differential lateral mobility of IgM and IgG receptors in motuse B Rapid transmembrane movement of newly synthesized phospholipids lymphocyte membranes, 4595 during membrane assembly, 1821 Membrane, microsomal Release of Escherichia coli DNA from membrane complexes by Cell-free synthesis of fish preproinsulin, and processing by heterologotus single-strand endonucleases, 2756 mammalian microsomal membrarnes, 2059 Membrane, basolateral Nascent prehormones are intermediates in biosynthesis of authentic TIransport of ar-amylase across basolateral membrane of pancreatic bovine pituitary growth hormone and prolactin, 2432 aciniar cell, 4068 Membrane microviscosity Membrane bilayer Changes in membrane microviscosity associated with phagocytosis: Glycerophospholipid synthesis: Improved general method and new Effects of colchicine, 1072 analogs containing photoactivable groups, 4315 Membrane, mitochondrial Membrane, brain Antigenic distinctions of glycoproteins in plasma and mitochondrial Specific benzodiazepine receptors in rat brain characterized by membranes of lymphoid cells neoplastically transfrormed by simian high-affinity [3H]diazepam binding, 3805 virus 40, 643 Membrane, cell Enzymatic formation of glutathione-citryl thioester by mitochondrial Animal cell mutants defective in sterol metabolism: Specific selection system and inhibition by (-)erythrofluorocitrate, 4942 procedure and partial characterization of defects, 3730 Location of protein(s) irnvolved in oligomycin-induced inhibition of' Biochemical characterization of mutant lipoprotein of Escherichia coli, mitochondrial adenosinetriphosphatase near outer surface of' inner 1388 membrane, 4185 Cellutlar division in Escherichia coli: Mutant of E. coli lacking a Membrane mobility agent murein-lipoprotein, 1417 Inhibition of cytokinesis in Friend leukemia cells by mnembranemobility P'otassiumnionophore (valinomycin) inhibits lymphocyte proliferation by agents, 2884 its effects on cell membrane (correction), 392 Membrane, model Protein structure of probable membrane derivation associated with Immunogenicity of liposomal model membranes in mice: Dependence on HeI.a cell mitochondrial DNA near its origin of replication, 1348 phospholipid composition, 1234 Specific factors influencing histotypic aggregation of chick embryo Rhodopsin in model membranes: Charge displacements in interfacial hepatocytes, 4486 layers, 207 Tritium suicide selection of mammalian cell mutants defective in Water molecules: Arrangement in cavities and channels of lattice of' tranosportof nerutralamino acids, 4549 [Phe4Val6]antamanide dodecahydrate, 2602 Ultrastructural localization of cell membrane GM1ganglioside by cholera Membrane, muscle toxin, 3782 Development of' electrophysiological arndbiochemical membrane Membrane, cell surface properties during differentiation of' embryonic skeletal muscle in Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface culture, 5166 membranes, 2251 Isolation and characterization of muscle membranes usilng Inhibition of DNA synthesis in cultures of' 3T3 cells by isolated surface surface-specific labels, 34 membranes (correction), 4706 Membrane, muscle fiber basement Membrane, chorioallantoic Reinnervation of original synaptic sites on muscle fiber basement Calcium-binding protein of chorioallantoic membrane: Identification and membrane after disruption of muscle cells, 3073 developmental expression, 1946 Membrane mutant Membrane conductance Cell surface carbohydrates and proteins in cell behavior: Biochemical Voltage-dependent facilitation of Ca2+ entry in voltage-clamped, reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 aequorin-injected molluscan neurons, 1748 Membrane, nerve Membrane, cytoplasmic Molecular events and energy changes during action poteintial, 3810 Membrane-associated assembly of M13 phage in extracts of Random walk analysis of potassium fluxes associated with nerve virus-infected Escherichia coli, 505 impulses, 5543 Membrane depolarization Membrane, nerve cell Batrachotoxin affects electroplax of electric eel: Voltage-dependent Synaptic acetylcholine receptor sites identified in retina with interaction with sodium channels, 951 peroxidase-labeled (o-bungarotoxin, 3268 Membrane, electroplax Membrane permeability Furnctional acetylcholine receptor-electroplax membrane microsacs C-reactive protein and complement interact with liposomes, 5672 (vesicles): Purification and characterization, 482 Membrane, photosynthetic Membrane, enzyme Chlorophyll b identified in extracts of prokaryotic algae by fluorescence Kinetic and electrochemical memory in einzyme membranes, 5314 spectroscopy, 575 Membrane, erythrocyte Membrane, plasma Abnormal lithium and sodium transport in erythrocytes of manic patient Adhesive specificity of'juvenile rat and chicken liver cells and and some members of his family, 3607 membranes, 1077 Adenoylate cyclase-free, /-adrenergic receptor isolated from turkey Antibody-induced linkages of plasma membrane proteins to intracellular erythrocyte membranes by affinity chromatography, 3710 actomyosin-containing filaments in cultured fibroblasts, 5584 Catecholamine binding to /-adrenergic receptor, 515 Antigenic distinctionrs of glycoproteins in plasma and mitochondrial Plasma membrane proteins: Changes in composition during membranes of lymphoid cells neoplastically transformed by simnia differentiation of embryonic chick erythroid cell, 1062 virus 40, 643 Spectrin induced in erythroleumkemic cells transformed by Friend virus, Antipain and leupeptin restrict uterine D)NA synthesis and function in 3898 mice, 3754 Membrane, fertilization Cellular uptake and nuclear binding of insulin in human cultured Release of ovoperoxidase from sea urchin eggs hardens fertilization lymphocytes: Potential intracellular sites of insulin action, 1368 membrane with tyrosine crosslinks, 4214 Cholinergic ligands and local anesthetics interact with plasma membrane Membrane, fibroblast fragments from lobster axon, 2278 Factor that binds glucose and stimulates its transport isolated from Effects of thyrotropin on thyroid cell membrane: Hyperpolarization normal and Rous sarcoma virus-transformed chicken fibroblasts, 163 induced by hormrone-receptor interaction, 2352 Membrane fluidity Nerve growth factor receptors: Identification of distinct classes in plasma Differential lateral mobility of IgM and IgG receptors in mouse B membranes and nuclei of embryonic dorsal root neuroms, 2785 lymphocyte membranes, 4595 Protein related to tubulin identified in the postsynaptic density, 1047 Endocytosis: Response to altered fatty acyl composition of macrophage Roles of proteins from inner face of plasma membranes in susceptibility phospholipids, 4895 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5827

of (Na+ + K+)-stimulated Mg2+ adenosinetriphosphatase to ouabain, Excited state lifetimes in cytochromes measured from Raman scattering 633 data: Iron-porphyrin interactions, 2607 Selective loss of wheat germ agglutinin binding to agglutinin-resistant Kinetics of hemoglobin-carbon monoxide reactions measured with a mutants of Chinese hamster ovary cells, 5056 superconducting magnetometer: Method for fast reactions in solution, Simian virus 40-specific proteins in membranes of simian virus 2620 40-transformed hamster and mouse cells, 5069 Metal-metal interaction Third complement protein and cell surface macromolecules: Interaction, Detailed electronic description of triple bonds between transition metal 2701 atoms and verification by photoelectron spectroscopy, 3109 Topographic separation of adenylate cyclase and hormone receptors in Synthesis and characterization of "face-to-face" porphyrins, 18 plasma membrane of toad erythrocyte ghosts, 2860 Metal toxicity Transmembrane bridging proteins identified in plasma membrane of Regulation of heme pathway enzymes and cellular glutathione content cultured mouse L cells, 5341 by metals that do not chelate with tetrapyrroles: Blockade of metal Virus-specific proteins in plasma membrane of cells lytically infected or effects by thiols, 1875 transformed by polyoma virus, 4666 Metal, transition Membrane potential Covalence of atoms in the heavier transition metals, 2614 Sensory electrophysiology of bacteria: Relationship of membrane Structure of transition-metal cluster compounds: Use of additional potential to motility and chemotaxis in Bacillus subtilis, 4752 orbital resulting from f, g character of spd bond orbitals, 5235 Membrane protein Methane-producing bacteria Accelerated degradation of acetylcholine receptor from cultured rat Methanogenic bacteria classified by 16S ribosomal RNA myotubes with myasthenia gravis sera and globulins, 2130 characterization, 4537 Antibody-induced linkages of plasma membrane proteins to intracellular Methanogenic bacteria classified by 16S ribosomal RNA characterization actomyosin-containing filaments in cultured fibroblasts, 5584 (correction), 5778 Biosynthesis of covalently linked diglyceride in murein lipoprotein of Phylogenetic structure of prokaryotic domain: Primary kingdoms, 5088 Escherichia coli, 5318 Methionine Charge shift electrophoresis: Method for distinguishing between Sensory transduction in Escherichia coli: Requirement for methionine in amphiphilic and hydrophilic proteins in detergent solution, 529 sensory adaptation, 183 Cytochrome bs: Primary structure of membranous segment, 3725 Methionine sulfoximine Deuterium magnetic resonance studies of interaction of lipids with Selective inhibition of y-glutamyl-cycle enzymes by substrate analogs, membrane proteins, 5435 3330 Escherichia coli alkaline phosphatase precursor: Synthesis and Methionine synthetase processing in vitro, 1440 see Tetrahydropteroylglutamate methyltransferase Gene fusions used to study outer membrane protein localization in Methodology Escherichia coli, 5411 Adenylate cyclase-free, /-adrenergic receptor isolated from turkey Glucose depletion accounts for induction of two transformation-sensitive erythrocyte membranes by affinity chromatography, 371.0 membrane proteins in Rous sarcoma virus-transformed chick embryo Analysis of single- and double-stranded nucleic acids on polyacrylamide fibroblasts, 3840 and agarose gels by using glyoxal and acridine orange, 4835 Levels of translatable mRNAs for cell surface protein, collagen Animal cell mutants defective in sterol metabolism: Specific selection precursors, and two membrane proteins are altered in Rous sarcoma procedure and partial characterization of defects, 3730 virus-transformed chick embryo fibroblasts, 3399 Bacteriophage system for screening and study of biologically active Light-regulated permeability of rhodopsin:egg phosphatidylcholine polycyclic aromatic hydrocarbons and related compounds, 1378 recombinant membranes, 5222 Biotinylinsulins as potential tools for receptor studies, 2697 Lipid and protein segregation in Escherichia coli membrane: Calcium-induced luminescence of aequorin: Reversible and irreversible Morphological and structural study of different cytoplasmic membrane inhibition by anesthetics, 5534 fractions, 452 Charge shift electrophoresis: Method for distinguishing between Mobility and distribution of a cell surface glycoprotein and its amphiphilic and hydrophilic proteins in detergent solution, 529 interaction with other membrane components, 2909 Chemiluminescent reactions and electrophilic oxygen donating ability of Molecular weight of bacteriorhodopsin solubilized in Triton X-100, 2803 4a-hydroperoxyflavins: Preparation of N5-alkyl-1,5-dihydroflavins, 405 Phosphorylation of membrane proteins at cholinergic synapse, 263 Cloning specific segments of mammalian genome: Bacteriophage A Plasma membrane proteins: Changes in composition during containing mouse globin and surrounding gene sequences, 4406 differentiation of embryonic chick erythroid cell, 1062 Concentration of mutagens from urine by adsorption with nonpolar resin Specific radiolabeling of cell surface receptor for epidermal growth XAD-2: Cigarette smokers have mutagenic urine, 3555 factor, 2790 Daily cholesterol synthesis rates in man measured by assay of fractional Membrane structure conversion of mevalonic acid to cholesterol, 3043 Transmembrane movement of cholesterol in human erythrocytes, 1538 Detection of specific RNAs in agarose gels by transfer to Membrane, surface diazobenzyloxymethyl-paper and hybridization with DNA probes, 5350 Transformation by simian virus 40 induces virus-specific, related Diphtheria toxin: Relationship between structure and function, 472 anmtigens in surface membrane and nuclear envelope, 2495 Dissociation and reassociation of immobilized porphobilinogen synthase: Membrane, synaptic Use of immobilized subunits for enzyme isolation, 1383 Neurotensin: Specific binding to synaptic membranes from rat brain, DNA sequencing with chain-terminating inhibitors, 5463 1846 Electron microscopy of negatively stained and freeze-etched high density Membrane vesicle lipoprotein-3 from human serum, 5001 Calcium translocation by Golgi and lateral-basal membrane vesicles from Enzymatic synthesis of oligonucleotides of defined sequence: Synthesis rat intestine: Decrease in vitamin D-deficient rats, 3612 of segment of yeast iso-l-cytochrome c gene, 96 Isolation of virus-free Herpesvirus saimiri antigen-positive plasma Enzyme replacement therapy in Gaucher's disease: Large-scale membrane vesicles, 2546 purification of glucocerebrosidase suitable for human administration, Sodium-stimulated glutamate uptake in membrane vesicles of 3560 Escherichia coli: Role of ion gradients, 3167 Erythropoietin: Isolation by affinity chromatography with lectin-agarose Membranoproliferative glomerulonephritis derivatives, 4633 Heterogeneity of nephritic factor and its identification as an Expression of petite mitochondrial DNA in vivo: Zygotic gene rescue, immunoglobulin, 3980 2715 Memory Glycolipid-bound siaiic acid in serum: Increased levels in mice and Brain protein metabolism and acquisition of new patterns of behavior, humans bearing mammary carcinomas, 3011 1743 How to label nerve cells so that they can interconnect in an ordered p-Mercuribenzoate fashion, 5176 Homoserine dehydrogenase: Spontaneous reactivation by dissociation of Human erythrocyte pyrimidine 5'-nucleotidase: Purification and p-mercuribenzoate from inactive enzyme-p-mercuribenzoate complex, properties, 3701 4862 Human leukocytic pyrogen: Purification and development of Mercurinucleotide radioimmunoassay, 4624 Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: Human plasma proteins: High resolution two-dimensional Increased transcription during erythroid differentiation, 2475 electrophoresis, 5421 Mercury 3-Hydroxy-3-methylglutaryl-coenzyme A reductase purified from rat Electrophilic mercuration and thallation of benzene and substituted liver, 1431 benzenes in trifluoroacetic acid solution, 4121 125I-labeled phytochrome used to quantitate phytochrome binding to Meromyosin, light membranes of Avena satiuva, 4439 Flexibility of myosin rod, light meromyosin, and myosin subfragment-2 in Interspecies radioimmunoassay for major structural proteins of primate solution, 4986 type-D retroviruses, 5739 Metabolic inhibitor Isolation and characterization of muscle membranes using Polypeptide synthesis initiated with various NH2-blocked surface-specific labels, 34 aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5909 Isolation and preliminary characterization of 10-nm filaments from baby Metabolism hamster kidney (BHK-21) cells, 2422 see also Amino-acid metabolism; Hydrocarbon metabolism Isolation of chloroplast N,N'-dicyclohexylcarbodiimide-binding Collagen degradation in rat skin but not in intestine during rapid proteolipid, active in proton translocation, 2375 growth: Effect on collagen types I and III from skin, 1.436 Kinetics of hemoglobin-carbon monoxide reactions measured with a '31p nuclear magnetic resonance studies of Ehrlich ascites tumor cells, 87 superconducting magnetometer: Method for fast reactions in solution, Metalloprotein 2620 see also Protein, copper; specific metals Local control of neurite development by nerve growth factor, 4516 Enzymatic formation of glutathione-citryl thioester by mitochondrial Method for cloning eukaryotic structural gene sequences (correction), system and inhibition by (-)erythrofluorocitrate, 4942 2187 Downloaded by guest on September 27, 2021 5828 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Method for localizing proteins in periodic structures: Fab fragment Microcomplement fixation labeling combined with image processing of electron micrographs, 5514 Microcomplement fixation studies on evolution of a-glycerophosphate Method for obtaining a high resolution protein map starting from a low dehydrogenase within genus Drosophila, 684 resolution map, 2835 Microfilament Method for sequencing DNA, 560 Cultured aortic endothelial cells from pigs with von Willebrand disease: Microsurgically produced homozygous-diploid uniparental mice, 5657 In vitro model for studying molecular defect(s) of the disease, 5702 Molecular hybridization used to purify and analyze albumin messenger Cyclic AMP, microtubule-microfilament system, and cancer, 4491 RNA from rat liver, 4346 Interaction of filamin with F-actin in solution, 2021 Moloney leukemia virus-induced cell surface antigen: Detection and Intracellular distributions of mechanochemical proteins in cultured characterization in sodium dodecyl sulfate gels, 5270 fibroblasts, 3883 Multihormonal induction of hepatic a2u-globulin mRNA measured by Nerve growth factor prevents vinblastine destructive effects on hybridization to complementary DNA, 4791 sympathetic ganglia in newborn mice, 5559 Native human hemoglobin reconstituted from separated globin chains Phalloidin-induced actin polymerization in cytoplasm of cultured cells and alloplex intermediates, 64 interferes with cell locomotion and growth, 5613 Nucleic acid components: Ultraviolet resonant Raman spectroscopy, 2639 /2-Microglobulin Nucleic acid regulatory sequences: Computer analysis, 4401 Antibody-induced linkages of plasma membrane proteins to intracellular Phage T4-modified RNA polymerase transcribes T4 late genes in vitro, actomyosin-containing filaments in cultured fibroblasts, 5584 5305 Crystallographic studies of bovine /2-microglobulin, 3345 Physical-chemical approach to transient change in Na ion conductivity Microiontophoresis of excitable membranes (correction), 3621 Neuronal actions of endorphins and enkephalins among brain regions: Polylysine used for adsorption of nucleic acids and enzymes to electron Comparative microiontophoretic study, 2584 microscope specimen films, 2311 Microsac Polypeptide synthesis initiated with various NH2-blocked Functional acetylcholine receptor-electroplax membrane microsacs aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5909 (vesicles): Purification and characterization, 482 Protein-sugar interactions: Preparation, purification, and properties of Microsome rabbit antibodies against di-N-acetylchitobiose, 168 Major adducts formed by reaction of benzo[a]pyrene diol epoxide with Putative precursor of globin messenger RNA purified from mouse DNA in vitro, 5285 nucleated erythroid cells, 178 Post-translational cleavage of presecretory proteins with extract of rough Quantitative determination of transformed cells in a mixed population microsomes from dog pancreas containing signal peptidase activity, by simultaneous fluorescence analysis of cell surface and DNA in 5598 individual cells, 1626 Microsurgery Radioimmunoassay of creatine kinase-B isoenzyme in human sera: Microsurgically produced homozygous-diploid uniparental mice, 5657 Results in patients with acute myocardial infarction, 1711 Microtubule Random walk analysis of potassium fluxes associated with nerve Addition of colchicine-tubulin complex to microtubule ends: Mechanism impulses, 5543 of substoichiometric colchicine poisoning, 3466 Ribosome structure: Localization of N6,N6-dimethyladenosine by Antitubulins affect redistribution of crosslinked receptors on surface of electron microscopy of a ribosome-antibody complex, 1468 fibroblasts and epithelial cells, 2865 Rotational relaxation of 70S ribosomes by a depolarization method using Changes in membrane microviscosity associated with phagocytosis: triplet probes, 1407 Effects of colchicine, 1072 Selective scattering spectra as an approach to internal structure of granal Ciliary rows: 180? rotation and its morphogenetic implications in and agranal chloroplasts, 1455 Tetrahymena pyriformis, 1115 Shape of 50S subunit of Escherichia coli ribosomes, 2316 Colchicine affects cyclic AMP levels in human leukocytes, 3404 Simultaneous measurements of viscosity and density in solutions Cyclic AMP, microtubule-microfilament system, and cancer, 4491 undergoing change, 4430 Direction of active sliding of microtubules in Tetrahymena cilia, 2045 Sites of transcription initiation in vivo on Xenopus laevis ribosomal Disagreement between calorimetric and van't Hoff enthalpies of DNA, 5402 assembly of protein supramolecular structures, 2002 Structural gene identification and mapping by DNA-mRNA Guanosinetriphosphatase activity of tubulin associated with microtubule hybrid-arrested cell-free translation, 4370 assembly, 5372 Structure determination of gaseous and amorphous substances by Immunofluorescent staining of cytoplasmic and spindle microtubules in diffraction methods: Philosophical concepts and their implementation mouse fibroblasts with antibody to T protein, 2437 (Review), 4707 In vitro assembly of pure tubulin into microtubules in absence of Synthesis of a 19-residue peptide with alamethicin-like activity, 115 microtubule-associated proteins and glycerol, 1860 Thymopoietin and thymic hormone levels in human plasma: Bioassay Microtubule structure at low resolution by x-ray diffraction, 3370 determinations, 2541 Nerve growth factor prevents vinblastine destructive effects on Transmembrane interactions and mechanism of capping of surface sympathetic ganglia in newborn mice, 5559 receptors by their specific ligands, 5031 Phalloidin-induced actin polymerization in cytoplasm of cultured cells Tritium suicide selection of mammalian cell mutants defective in interferes with cell locomotion and growth, 5613 transport of neutral amino acids, 4549 Photoaffinity analog of GTP interacts with proteins of microtubules, Troponin-like complex isolated from bovine brain cortex, 2273 4375 Ultrastructural localization of cell membrane GM1ganglioside by cholera Protein related to tubulin identified in the postsynaptic density, 1047 toxin, 3782 Receptor diffusion on cell surfaces modulated by locally bound Methyl anion concanavalin A, 1110 Electron affinity of methyl radical: Structures of CH3 and CH3-, 410 Role of nucleotides in tubulin polymerization: Effect of guanylyl Methylcholanthrene 5'-methylenediphosphonate, 4881 Antigen-specific purification of blocking factors from sera of mice with Role of surface modulating assemblies in growth control of normal and chemically induced tumors, 4605 transformed fibroblasts, 666 Chemical transformation of rat cell infected with xenotropic type-C Stimulus-secretion coupling in chromaffin cells isolated from bovine RNA virus and its suppression by virus-specific antiserum, 579 adrenal medulla, 5036 Heteroploid conversion of human skin cells by methylcholanthrene, 2451 Stoichiometry of GTP hydrolysis and tubulin polymerization, 462 .Methylglyoxal Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit Electronic properties of casein-methylglyoxal complex, 226 synthesis of brain-specific protein in rat glial cells, 3855 Electron spin resonance absorption of tissue constituents, 1558 Microvillus Living state and cancer, 2844 Ligand-independent cap formation: Redistribution of surface receptors Methylmalonyl-CoA mutase (EC 5.4.99.2) on mouse lymphocytes and thymocytes in hypertonic nmedium,4511 Intracellular binding of radioactive hydroxocobalamin to Microviscosity cobalamin-dependent apoenzymes in rat liver, 916 Microviscosity modulation during cell cycle of neuroblastoma cells, 4458 Recognition of two intracellular cobalamin binding proteins and their Migration identification as methylmalonyl-CoA mutase and methionine Decay of genetic variability in geographically structured populations, synthetase, 921 2523 Methyl radical Migration inhibitory factor Electron affinity of methyl radical: Structures of CH3 and CH3-, 410 Macrophage migration inhibitory activity generated by plasminogen Metronidazole activators, 1570 Selective enrichment of photosynthetic electron transport mutants, 610 Milk Mevalonate kinase. (EC 2.7.1.36) Zinc-binding ligands in milk and intestine: Role in neonatal nutrition? Cholesterol synthesis in rat adrenal gland regulated through coordinate 3547 control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and Milk fat globule reductase activities, 1421 Surface differentiation antigens of human mammary epthelial cells Mevalonic acid carried on human milk fat globule, 582 Daily cholesterol synthesis rates in man measured by assay of fractional Mitochondrion conversion of mevalonic acid to cholesterol, 3043 see also Membrane, mitochondrial Microcell Dehydrogenase and transhydrogenase properties of soluble NADH Microcell-mediated transfer of murine chromosomes into mouse, Chinese dehydrogenase of bovine heart mitochondria, 846 hamster, and human somatic cells, 319 Electrogenic K+/Ca2+ ionophore isolated from an ionophoroprotein of Stable association of human transgenome and host murine chromosomes beef heart mitochondria, 3667 demonstrated with trispecific microcell hybrids, 3937 Enzymatic formation of glutathione-citryl thioester by mitochondrial Micrococcal nuclease system and inhibition by (-)erythrofluorocitrate, 4942 Protein scaffold isolated from mitotic HeLa cell chromosomes, 4937 Expression of petite mitochondrial DNA in vivo: Zygotic gene rescue, 2715 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5829

Fi-ATPase-catalyzed synthesis of ATP from oleoylphosphate and ADP, Morphogenesis 4919 Biogenesis of poxviruses: Analysis of morphogenetic sequence using a Genetic control of mitochondrial malate dehydrogenases: Evidence for conditional lethal mutant defective in envelope self-assembly, 2162 duplicated chromosome segments, 310 Ciliary rows: 180? rotation and its morphogenetic implications in H+/ATP ratio during ATP hydrolysis by mitochondria: Modification of Tetrahymena pyriformis, 1115 chemiosmotic theory, 1955 Packaging recombinant DNA molecules into bacteriophage particles in Hepatic mitochondrial cytochrome P-450: Isolation and functional vitro, 3259 characterization, 5477 Morphometrics High aerobic glycolysis of rat hepatoma cells in culture: Role of Evolutionary consequences of parthenogenesis: Evidence from the mitochondrial hexokinase, 3735 Warramaba virgo complex, 1130 125I-labeled phytochrome used to quantitate phytochrome binding to Mossbauer effect membranes of Avena sativa, 4439 Surface, catalytic, and magnetic properties of small iron particles: Effect Location of protein(s) involved in oligomycin-induced inhibition of of chemisorption of hydrogen on magnetic anisotropy, 806 mitochondrial adenosinetriphosphatase near outer surface of inner Moth membrane, 4185 see Antheraea polyphemus; Plodia interpunctella 3-Nitropropionate, the toxic substance of Indigofera, is a suicide Motility inactivator of succinate dehydrogenase, 3767 Sensory electrophysiology of bacteria: Relationship of membrane Oligomycin-dependent ionophoric protein subunit of mitochondrial potential to motility and chemotaxis in Bacillus subtilis, 4752 adenosinetriphosphatase, 4306 Mouse, nude Surface localization of sites of reduction of nitroxide spin-labeled Growth of cultured cells from patients with Hodgkin's disease and molecules in mitochondria, 570 transplantation into nude mice, 754 Uncouplers and molecular mechanism of uncoupling in mitochondria, Tumorigenicity of simian virus 40-transformed human cells and 2241 mouse-human hybrids in nude mice, 1142 Unique DNA associated with mitochondria in "S"-type cytoplasm of Mouse, uniparental male-sterile maize, 2904 Microsurgically produced homozygous-diploid uniparental mice, 5657 Mitogen Mucopolysaccharidosis Sugar uptake and thymidine incorporation in mouse 3T3 cells stimulated Active heteropolymeric /-glucuronidase detected in hybrids between by calcium phosphate and other extracellular particles, 5593 mouse cells and human fibroblasts with /-glucuronidase deficiency, Variants of 3T3 cells lacking mitogenic response to epidermal growth 2948 factor, 3918 Multienzymecomplex Mitogenesis Acyl group and electron pair relay system: Network of interacting lipoyl Lymphocyte mitogenesis induced by mammalian liver protein that moieties in pyruvate and r-ketoglutarate dehydrogenase complexes specifically binds desialylated glycoproteins, 676 from Escherichia coli, 4223 Mitosis Fatty acid synthetase from Brevibacterium ammoniagenes: Formation of Cell-cycle-related changes of 3':5'-cyclic GMP levels in Novikoff monounsaturated fatty acids by multienzyme complex, 3180 hepatoma cells, 1052 Murein Developmental defects associated with glucosamine auxotropy in Biochemical characterization of mutant lipoprotein of Escherichia coli, Saccharomyces cerevisiae, 4351 1388 Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during Biosynthesis of covalently linked diglyceride in murein lipoprotein of cell cycle of mouse mastocytoma cells, 1610 Escherichia coli, 5318 Mitotic Ca2+-adenosinetriphosphatase: Synthesis and activation during Cellular division in Escherichia coli: Mutant of E. coli lacking a cell cycle of mouse mastocytoma cells (correction), 3621 murein-lipoprotein, 1417 Molecular cloning Murinemammary tumor virus Replication and expression of plasmids from Staphylococcus aureus in Glucocorticoid-stimulated accumulation of mouse mammary tumor virus Bacillus subtilis, 1680 RNA: Increased rate of synthesis of viral RNA, 2879 Molecular eigenstate Multiple antigenic determinants on major surface glycoprotein of murine Radiationless relaxation in "large" molecules: Preparation of true mammary tumor viruses, 3564 molecular eigenstates and Born-Oppenheimer states by a coherent Muscimol light source, 1310 Mechanisms by which diazepam, muscimol, and other drugs change the Molecular orbital content of cGMP in cerebellar cortex, 3592 see also Orbital, hybrid Muscle Detailed electronic description of triple bonds between transition metal see also Cell, muscle atoms and verification by photoelectron spectroscopy, 31:09 Affinity alkylation labels two subunits of reduced acetylcholine receptor Electron affinity of methyl radical: Structures of CH3 and CH3-, 410 from mammalian muscle, 4685 Transition state structures of dipeptide related to mode of action of Evidence from UV transcription mapping in HeLa cells that /-lactam antibiotics, 5239 heterogeneous nuclear RNA is the messenger RNA precursor, 4524 Molecular phylogeny Flexibility of myosin rod, light meromyosin, and myosin subfragment-2 in Phylogenetic structure of prokaryotic domain: Primary kirngdoms, 5088 solution, 4986 Molecular structure Modulation of acetylcholine receptor by antibody against receptor, 3090 Mathematical description of molecular structure: Molecular topology, 31P nuclear magnetic relaxation studies of phosphocreatine in intact 2616 muscle: Determination of intracellular free magnesium, 4271 Molecular surface area Muscle,cardiac Use of solvent cavity area and number of packed solvent molecules Actin microheterogeneity in chick embryo fibroblasts, 120 around a solute in regard to hydrocarbon solubilities an(d hydrophobic Muscle fiber interactions, 4144 Effect of MgATP on stiffness measured at two frequencies in Molecule Ca2+-activated muscle fibers, 4073 Structure determination of gaseous and amorphous substances by Muscle,skeletal diffraction methods: Philosophical concepts and their implementation Development of electrophysiological and biochemical membrane (Review), 4707 properties during differentiation of embryonic skeletal muscle in Molting hormone culture, 5166 Secretion of a-ecdysone by crab Y-organs in vitro, 615 Effect of uridine on cellular UTP and glycogen synthesis in skeletal Molybdate muscle: Stimulation of UTP formation by insulin, 2339 Derepression of ATP sulfurylase by sulfate analogs molybdate and 31P nuclear magnetic resonance studies of glycogen phosphorylase from selenate in cultured tobacco cells, 619 rabbit skeletal muscle: Ionization states of pyridoxal 5'-phosphate, 856 Molybdenum Muscle, smooth Detailed electronic description of triple bonds between transition metal Actin microheterogeneity in chick embryo fibroblasts, 120 atoms and verification by photoelectron spectroscopy, 3109 Interaction of filamin with F-actin in solution, 2021 Isolation of iron-molybdenum cofactor from nitrogenase, 3249 Phosphorylation of smooth muscle myosin affects actin activation and Molybdenum cofactors from molybdoenzymes and in vitro reconstitution Ca2+ regulation, 129 of nitrogenase and nitrate reductase, 5468 Mutagen N- a-Monomethylalanine Concentration of mutagens from urine by adsorption with nonpolar resin Isopeptide linkage between N-ra-monomethylalanine and lysine in XAD-2: Cigarette smokers have mutagenic urine, 3555 ribosomal protein Sll from Escherichia coli, 4905 Sequence specificity of mutagen-nucleic acid complexes in solution: Monte Carlo procedure Intercalation and mutagen-base pair overlap geometries for proflavine Protein folding: Incorporation of a one-dimensional short-range (Ising) binding of dC-dC-dG-dG and dG-dG-dC-dC self-complementary model into a three-dimensional model, 1320 duplexes, 2624 Monte-Carlotrial Mutagenesis Robust nonlinear data smoothers: Definitions and recommendations, 434 2-Aminopurine-induced mutagenesis in T4 bacteriophage: Model relating Morphine mutation frequency to 2-aminopurine incorporation in DNA, 4806 see also Receptor, morphine Cholesterol-requiring mutant of Chinese hamster ovary cells: Isolation Biologically active conformation of opiates and enkephalin, 5179 and partial characterization, 832 Endogenous nonpeptide morphine-like compound: Binding to opiate Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to receptors, 4927 ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 /-Endorphin: Behavioral and analgesic activity in cats, 774 Mutagenicity and cytotoxicity of benz[ a]anthracene diol epoxides and Mechanisms by which diazepam, muscimol, and other drugs change the tetrahydro-epoxides: Exceptional activity of bay region 1,2-epoxides, content of cGMP in cerebellar cortex, 3592 2746 Opiate receptor: Cooperativity of binding observed in brain slices, 5764 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Downloaded by guest on September 27, 2021 5830 SubjectIndex Proc. Natl. Acad. Sci. USA 74 (1977)

prevents X repressor inactivation, ultraviolet mutagenesis, and Modulation of acetylcholine receptor by antibody against receptor, 3090 filamentous growth, 1152 Mycoplasma pneumoniae Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Actin-like protein extracted from prokaryote Mycoplasma pneumoniae, prevents X repressor inactivation, ultraviolet mutagenesis, and 4041 filamentous growth (correction), 2594 Myelin Rejection by syngeneic mice of cell variants obtained by mutagenesis of Density of sodium channels in mammalian myelinated nerve fibers and teratocarcinoma cell line, 272 nature of axonal membrane under myelin sheath, 211 Mutant, amber Prelarge and presmall basic proteins in mouse myelin and their Amber and ochre mutants of human virus Ad2+ND1 identified, 4567 structural relationship to large and small basic proteins, 3360 Bacteriophage T4 RNA ligase is gene 63 product, the protein that Myenteric plexus promotes tail fiber attachment to baseplate, 3355 Serotonergic neurons in peripheral nervous system: Identification in gut Conditional-lethal rho mutants of Escherichia coli: Isolation and by immunohistochemical localization of tryptophan hydroxylase, 3086 characterization, 1162 Myoblast Mutant, behavioral Actin microheterogeneity in chick embryo fibroblasts, 120 Sensory transduction in Escherichia coli: Two complementary pathways Do myoblasts in vivo withdraw from the cell cycle? 2031 of information processing that involve methylated proteins, 3312 Loss of growth control and differentiation in fu-1 variant of L8 line of rat Mutant, conditionally lethal ribosomal protein myoblasts, 3888 Conditionally lethal ribosomal protein mutants: Locus required for Synthesis and secretion of high molecular weight form of nerve growth modification of 50S subunit proteins, 467 factor by skeletal muscle cells in culture, 4496 Mutant, flagellar Myocardial infarction Flagellar mutants of Chlamydomonas: Studies of radial spoke-defective Radioimmunoassay of creatine kinase-B isoenzyme in human sera: strains by dikaryon and revertant analysis, 3456 Results in patients with acute myocardial infarction, 1711 Mutant, host-range Serum sex hormones and glucose, insulin, and lipid abnormalities in men Amber and ochre mutants of human virus Ad2+ND1 identified, 4567 with myocardial infarction, 1729 Mutant, initiation Myocardial necrosis DNA fragment containing origin of replication of Escherichia coli Radioimmunoassay of creatine kinase-B isoenzyme in human sera: chromosome, 2720 Results in patients with acute myocardial infarction, 1711 Mutant, insertion Myogenesis Genetic instability in Drosophila melanogaster: Putative multiple Evidence from UV transcription mapping in HeLa cells that insertion mutants at singed bristle locus, 2973 heterogeneous nuclear RNA is the messenger RNA precursor, 4524 Mutant, nonmotile Myogenic mechanism Cell-to-cell stimulation of movement in nonmotile mutants of Interaction of myogenic and neurogenic mechanisms that control heart Myxococcus, 2938 rate, 1761 Mutant, ochre Myoglobin Amber and ochre mutants of human virus Ad2+ND1, identified, 4567 Dioxygen bonding in hemoglobin: Molecular description, 1315 Mutant, pH-conditional Pressure affects visible spectra of complexes of myoglobin, hemoglobin, pH-conditional mutant of Escherichia coli, 5637 cytochrome c, and horse radish peroxidase, 1 Mutant, putative insertion Myosin Genetic instability in Drosophila melanogaster: De novo induction of see also Tropomyosin putative insertion mutations, 3490 Amino-acid sequence of myosin fragment that contains SH-1, SH-2, and Mutant, rho Nr-methylhistidine, 4281 Conditional-lethal rho mutants of Escherichia coli: Isolation and Antibody-induced linkages of plasma membrane proteins to intracellular characterization, 1162 actomyosin-containing filaments in cultured fibroblasts, 5584 Mutant, temperature-sensitive 4,4'-Bis(1-anilinonaphthalene 8-sulfonate): Probe of active site of Conditional-lethal rho mutants of Escherichia coli: Isolation and myosin, 2334 characterization, 1162 Calcium control of actin-activated myosin adenosine triphosphatase from DNA fragment containing origin of replication of Escherichia coli Dictyostelium discoideum (correction), 392 chromosome, 2720 Evidence from UV transcription mapping in HeLa cells that Ecdysone: Roles in Drosophila development, 5099 heterogeneous nuclear RNA is the messenger RNA precursor, 4524 Escherichia coli mutant with temperature sensitive function affecting Flexibility of myosin rod, light meromyosin and myosin subfragment-2 in bacteriophage Q/1RNA replication, 1657 solution, 4986 Interaction between mutations of ribosomes and RNA polymerase: A Internal deletion mutant of a myosin heavy chain in Caenorhabditis pair of strA and rif mutants individually temperature-insensitive but elegans, 5336 temperature-sensitive in combination, 1157 Phosphorylation of smooth muscle myosin affects actin activation and Large-scale automated isolation of Escherichia coli mutants with Ca2+ regulation, 129 thermosensitive DNA replication, 3485 Transmembrane interactions and mechanism of capping of surface Regulatory function of simian virus 40 DNA replication for late viral receptors by their specific ligands, 5031 gene expression, 4831 Myotube Thermosensitive mutation in Escherichia coli simultaneously causing Accelerated degradation of acetylcholine receptor from cultured rat defects in penicillin-binding protein-lBs and in enzyme activity for myotubes with myasthenia gravis sera and globulins, 2130 peptidoglycan synthesis vitro, 5472 Development of electrophysiological and biochemical membrane Virus-specific proteins in plasma membrane of cells lytically infected or properties during differentiation of embryonic skeletal muscle in transformed by polyoma virus, 4666 culture, 5166 Mutant, tsA Dissociated ciliary ganglion neurons in vitro: Survival and synapse Identification of simian virus 40 tumor and U antigens, 447 formation, 5171 Mutatant, amber Synapse turnover: Formation and termination of transient synapses, Ribosomal mutations affect read-through of chain termination signal: 4977 Synthesis of bacteriophage X 0 gene protein in vitro, 689 Synthesis and secretion of high molecular weight form of nerve growth Mutation factor by skeletal muscle cells in culture, 4496 Genetic variability maintained under mutation and selection pressures in Myxococcus xanthus a finite population, 2509 Cell-to-cell stimulation of movement in nonmotile mutants of Mutator action by Escherichia coli strains carrying dnaE mutations, Myxococcus, 2938 3947 Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, 2514 Mutation, frameshift NADH dehydrogenase (EC 1.6.99.3) Mutagen-nucleic acid intercalative binding: Structure of Dehydrogenase and transhydrogenase properties of soluble NADH 9-aminoacridine-5-iodocytidylyl(3'-5')guanosine crystalline complex, dehydrogenase of bovine heart mitochondria, 846 188 Nalidixic acid Product of newly identified gene, glnF, is required for synthesis of Mechanism of action of nalidixic acid: Pturification of Escherichia coli glutamine synthetase in Salmonella, 1662 nalA gene product and its relationship to DNA gyrase and a Mutation frequency nicking-closing enzyme, 4767 Mutation frequencies in female mice and estimation of genetic hazards Nalidixic acid resistance: A second genetic character involved in DNA of radiation in women, 3523 gyrase activity, 4772 Mutation, somatic Naloxone Age incidence curves for cancer, 1341 Effects of naloxone on experimentally induced ischemic pain and on Antigen-binding mutants of mouse myeloma cells, 5687 mood in human subjects, 1291 Mutation, spontaneous /-Endorphin: Behavioral and analgesic activity in cats, 774 Genetic instability in Drosophila melanogaster: Putative multiple /-Endorphin: Development of tolerance and its reversal by insertion mutants at singed bristle locus, 2973 5-hydroxytryptophan in cats, 4017 Genetic instability in Drosophila melanogaster: De novo induction of Neuronal actions of endorphins and enkephalins among brain regions: putative insertion mutations, 3490 Comparative microiontophoretic study, 2584 Myasthenia gravis Opiate receptor: Cooperativity of binding observed in brain slices, 5764 Accelerated degradation of acetylcholine receptor from cultured rat National Academy of Sciences USA myotubes with myasthenia gravis sera and globulins, 2130 National Academy of Sciences USA: Classes, council, members, officers, Human myasthenia gravis: Electrophysiological and ultrastructural sections, 4078 evidence compatible with antibody attachment to acetylcholine National Academy of Sciences USA: Classes, council, members, officers, receptor complex (correction), 1301 sections (correction), 1301 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) SubjectIndex 5831

National policy Electrical stimulation of,preganglionic nerve increases tyrosine Weathermodification technology: Statistician's view (Review),4714 hydroxylase activity in sympathetic ganglia, 3078 Naturalselection Ethylphenacemide and phenacemide: Conformational similarities to Measuresof fitness and demographicstability, 384 diphenylhydantoin and stereochemical basis of anticonvulsant activity, Mechanismof genetic coadaptationin populationsof Drosophila 1264 melanogaster,324 Facilitation at neuromuscular junctions: Contribution to habituation and Negative feedbackregulation dishabituation of Aplysia gill withdrawal reflex, 1267 Derepressionof ATP sulfurylaseby sulfate analogsmolybdate and Heptadecapeptide gastrin in vagal nerve, 5707 selenate in culturedtobacco cells, 619 Histrionicotoxin enhances agonist-induced desensitization of Neomycinphosphotransferase acetylcholine receptor, 5754 Aminoglycoside-modifyingenzyme of antibiotic-producingbacterium How to label nerve cells so that they can interconnect in an ordered acts as determinantof antibioticresistance in Escherichiacoli, 999 fashion, 5176 Nephritic factor Immunocytochemical identification of substance P cells and their Heterogeneityof nephriticfactor and its identificationas an processes in rat sensory ganglia and their terminals in spinal cord: immunoglobulin,3980 Light microscopic studies, 3597 Nerve Immunohistochemical analysis of peptide pathways possibly related to see also Axon;Ganglion; Neuron; specific cells pain and analgesia: Enkephalin and substance P, 3081 Nerve excitation Immunological distinction between acetylcholine receptor and Physical-chemicalapproach to transientchange in Na ion conductivity a-bungarotoxin-binding component on sympathetic neurons, 4689 of excitable membranes(correction), 3621 Localization of motor neuron pools supplying identified muscles in Nerve fiber, myelinated normal and supernumerary legs of chick embryo, 3582 Density of sodium channelsin mammalianmyelinated nerve fibers and Mechanisms by which diazepam, muscimol, and other drugs change the natureof axonal membraneunder myelin sheath, 211 content of cGMP in cerebellar cortex, 3592 Nerve impulse Morphological differentiation of neuroblastoma cells in medium Randomwalk analysisof potassiumfluxes associatedwith nerve supplemented with delipidated serum, 3893 impulses,5543 Nerve growth factor increases activity of ornithine decarboxylase in Nerve impulsepropagation superior cervical ganglia of young rats, 4681 Molecularevents and energychanges during action potential, 3810 Neurophysin biosynthesis in normal rats and in rats with hereditary Subthresholdsolutions of the Hodgkin-Huxleyequations, 5199 diabetes insipidus, 4046 Nerve regeneration Neurotensin: Immunohistochemical localization in rat central nervous Selective reinnervationin skin-graftedRana pipiens: Neurophysiological system, 4059 and behavioralevidence, 5749 Neurotensin: Immunohistochemical localization in rat central nervous Nerve, vagal system (correction), 5777 Heptadecapeptidegastrin in vagal nerve,5707 Nonlinear analysis of cat retinal ganglion cells in the frequency domain, Nervoussystem 3068 see also Autonomicnervous system; Brain; Central nervous system; Opiate receptor: Cooperativity of binding observed in brain slices, 5764 Spinal cord Opioid peptide enkephalin: Immunohistochemical mapping in rat central Aplysia californica:Development of nervoussystem, 375 nervous system, 2167 Nervoussystem, peripheral Perhydrohistrionicotoxin: Potential ligand for ion conductance Serotonergicneurons in peripheralnervous system: Identification in gut modulator of acetylcholine receptor, 2172 by immunohistochemicallocalization of tryptophanhydroxylase, 3086 Regional dissociation of f-endorphin and enkephalin contents in rat Netropsin brain and pituitary, 5162 Netropsin-poly(dA-dT)complex in solution:Structure and dynamicsof Reinnervation of original synaptic sites on muscle fiber basement antibiotic-freebase pair regionsand those centeredon bound membrane after disruption of muscle cells, 3073 netropsin,5207 Selective reinnervation in skin-grafted Rana pipiens: Neurophysiological b-Neumannproblem and behavioral evidence, 5749 Complexsubmanifolds in real-analyticpseudoconvex hypersurfaces, 3126 Serotonergic neurons in peripheral nervous system: Identification in gut Sufficient conditionsfor subellipticityon weaklypseudo-convex by immunohistochemical localization of tryptophan hydroxylase, 3086 domains,2214 Somatostatin-like immunoreactivity occurs in some peripheral Neural crest sympathetic noradrenergic neurons, 3587 Anionicglycopeptides and glycosaminoglycanssynthesized by embryonic Specific projection of displaced retinal ganglion cells upon accessory neuraltube and neuralcrest, 1057 optic system in pigeon (Columbia livia), 1753 Anionicglycopeptides and glycosaminoglycanssynthesized by embryonic Thyrotropin-releasing hormone-like material in rat retina: Changes due neuraltube and neuralcrest (correction),4076 to environmental lighting, 3579 Nerve growthfactor receptors on humanmelanoma cells in culture,565 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Neural network activity by choline: Choline administration can increase cholinergic Nonlinearanalysis of cat retinal ganglioncells in the frequencydomain, transmission, 798 3068 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Neural tube activity by choline: Choline administration can increase cholinergic Anionicglycopeptides and glycosaminoglycanssynthesized by embryonic transmission (correction), 2594 neuraltube and neuralcrest, 1057 Ultrastructural identification of substance P cells and their processes in Anionicglycopeptides and glycosaminoglycanssynthesized by embryonic rat sensory ganglia and their terminals in spinal cord by neuraltube and neuralcrest (correction),4076 immunocytochemistry, 4050 Neuraminidase Voltage-dependent facilitation of Ca2+ entry in voltage-clamped, Ultrastructurallocalization of cell membraneGM1 gangliosideby cholera aequorin-injected molluscan neurons, 1748 toxin, 3782 Neurogenesis Neuraminidase(EC 3.2.1.18) Anionic glycopeptides and glycosaminoglycans synthesized by embryonic Effect of galactoseoxidase, with and withoutprior sialidase treatment, neural tube and neural crest, 1057 on viabilityof erythrocytesin circulation,4205 Anionic glycopeptides and glycosaminoglycans synthesized by embryonic Role of sialic acid in survivalof erythrocytesin circulation:Interaction of neural tube and neural crest (correction), 4076 neuraminidase-treatedand untreatederythrocytes with spleen and Independent expression of adrenergic phenotype by neural crest cells in liver at cellularlevel, 1521 vitro, 2899 Waldenstr6mmacroglobulin that is a cold agglutininand a cryoglobulin Independent expression of adrenergic phenotype by neural crest cells in because it binds N-acetylneuraminosylresidues, 4591 vitro (correction), 4706 Neurite Neurogenicmechanism Local controlof neuritedevelopment by nerve growthfactor, 4516 Interaction of myogenic and neurogenic mechanisms that control heart Neurobiology rate, 1761 Acetylcholine:Storage and releaseby a clonal cell line, 5184 Neurohypophysis Affinity alkylationlabels two subunits of reducedacetylcholine receptor Neurophysin biosynthesis in normal rats and in rats with hereditary from mammalianmuscle, 4685 diabetes insipidus, 4046 Aplysia californica:Development of nervoussystem, 375 Neuroleptic Biologicallyactive conformationof opiates and enkephalin,5179 Brain dopamine receptors: Detection with [3H]dihydroergocryptine, 3750 Brain proteinmetabolism and acquisitionof new patterns of behavior, Neuromuscularjunction 1743 Dissociated ciliary ganglion neurons in vitro: Survival and synapse Cellularadhesion altered by nerve growthfactor, 4055 formation, 5171 Cholinergic metabolism and synapse formation by a rat nerve cell line, Facilitation at neuromuscular junctions: Contribution to habituation and 2579 dishabituation of Aplysia gill withdrawal reflex, 1267 Cilia: Active role in sensory transduction, 793 Human myasthenia gravis: Electrophysiological and ultrastructural Determination of transmitter function by neuronal activity, 5767 evidence compatible with antibody attachment to acetylcholine Development of electrophysiological and biochemical membrane receptor complex (correction), 1301 properties during differentiation of embryonic skeletal muscle in Reinnervation of original synaptic sites on muscle fiber basement culture, 5166 membrane after disruption of muscle cells, 3073 Dissociated ciliary ganglion neurons in vitro: Survival and synapse Neuromuscularspecificity formation, 5171 Localization of motor neuron pools supplying identified muscles in Effect of increased potassium concentrations on particle motion within a normal and supernumerary legs of chick embryo, 3582 neurosecretory structure, 5759 Neuron Effects of early experience upon orientation sensitivity and binocularity see also Nerve of neurons in visual cortex of cats, 1272 Explant cultures of catecholamine-containing neurons from rat brain: Downloaded by guest on September 27, 2021 5832 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Biochemical, histofluorescence, and electron microscopic studies, 4471 by metals that do not chelate with tetrapyrroles: Blockade of metal Food, drug, and cosmetic dyes: Biological effects related to lipid effects by thiols, 1875 solubility, 2914 Nicotiana glauca Independent expression of adrenergic phenotype by neural crest cells in Chloroplast DNA distribution in parasexual hybrids shown by vitro, 2899 polypeptide composition of fraction I protein, 5109 Independent expression of adrenergic phenotype by neural crest cells in Nicotiana langsdorffii vitro (correction), 4706 Chloroplast DNA distribution in parasexual hybrids shown by Synapse turnover: Formation and termination of transient synapses, polypeptide composition of fraction I protein, 5109 4977 Nicotiana tabacum L. Voltage-dependent facilitation of Ca2+ entry in voltage-clamped, Promotion and inhibition of flower formation in a dayneutral plant in aequorin-injected molluscan neurons, 1748 grafts with a short-day plant and a long-day plant, 2412 Neuronal development Nicotinamide adenine dinucleotide Aplysia californica: Development of nervous system, 375 Gangliosides and substrate analogues affect hydrolysis of nicotinamide Neuron, ciliary ganglion adenine dinucleotide by choleragen, 74 Dissociated ciliary ganglion neurons in vitro: Survival and synapse Nicotinamide adenine dinucleotide (reduced) formation, 5171 Amino-acid transport into Ehrlich cells: Unexpected additional mode of Neuron, cortical energization, 1488 Immunohistochemical localization in rabbit brain of a peptide Nicotinamide mononucleotide resembling COOH-terminal octapeptide of cholecystokinin, 3033 Nucleotide phosphotransferase of Escherichia coli: Action on Neuron, embryonic dorsal root nicotinamide riboside and nicotinamide mononucleotide, 4160 Nerve growth factor receptors: Identification of distinct classes in plasma Nicotinamide nucleotide membranes and nuclei of embryonic dorsal root neurons, 2785 Dehydrogenase and transhydrogenase properties of soluble NADH Neuron, motor dehydrogenase of bovine heart mitochondria, 846 Localization of motor neuron pools supplying identified muscles in Nicotinamide riboside normal and supernumerary legs of chick embryo, 3582 Nucleotide phosphotransferase of Escherichia coli: Action on Neuron, retinal nicotinamide riboside and nicotinamide mononucleotide, 4160 Specific projection of displaced retinal ganglion cells upon accessory Nicotine optic system in pigeon (Columbia livia), 1753 Cholinergic ligands and local anesthetics interact with plasma membrane Neuron, sympathetic fragments from lobster axon, 2278 Acetylcholine: Storage and release by a clonal cell line, 5184 Nitella axillaris Determination of transmitter function by neuronal activity, 5767 Cell wall extension in Nitella as influenced by acids and ions, 1565 Immunological distinction between acetylcholine receptor and Nitrate reductase (NAD(P)H) (EC 1.6.6.2) r-bungarotoxin-binding component on sympathetic neurons, 4689 Molybdenum cofactors from molybdoenzymes and in vitro reconstitution Neuropeptide of nitrogenase and nitrate reductase, 5468 Cholecystokinin and its COOH-terminal octapeptide in pig brain, 3035 Nitric oxide Immunohistochemical localization in rabbit brain of a peptide Nitric oxide activates guanylate cyclase and increases guanosine resembling COOH-terminal octapeptide of cholecystokinin, 3033 3':5'-cyclic monophosphate levels in various tissue preparations, 3203 Thyrotropin-releasing hormone-like material in rat retina: Changes due Nitrogenase to environmental lighting, 3579 Isolation of iron-molybdenum cofactor from nitrogenase, 3249 Neurophysin Molybdenum cofactors from molybdoenzymes and in vitro reconstitution Neurophysin biosynthesis in normal rats and in rats with hereditary of nitrogenase and nitrate reductase, 5468 diabetes insipidus, 4046 Nitrogen-15 chemical shift Neurosecretory structure Nitrogen-15 nuclear magnetic resonance of aliphatic tripeptides, 1308 Effect of increased potassium concentrations on particle motion within a Nitrogen, di-, reduction neurosecretory structure, 5759 Synthesis and characterization of "face-to-face" porphyrins, 18 Neurospora Nitrogen fixation Major protein associated with fruiting body development in Neurospora Genetic mapping of Rhizobium meliloti, 2076 and related ascomycetes, 3831 Isolation of iron-molybdenum cofactor from nitrogenase, 3249 Neurospora crassa Recombinant plasmid that carries part of nitrogen fixation (nif) gene De novo synthesis of qa enzymes of Neurospora crassa duroing induction, cluster of Klebsiella pneumoniae, 2963 4256 1,4 Nitrogen-sulfur interaction Expression in Escherichia coli K-12 of structural gene for catabolic Stable conformations of aliphatic disulfides: Influence of 1,4 interactions dehydroquinase of Neurospora crassa, 3508 involving sulfur atoms, 13 Involvement of an internal promoter in regulation and synthesis of 3-Nitropropionate mitochondrial and cytoplasmic leucyl-tRNA synthetases of 3-Nitropropionate, the toxic substance of Indigofera, is a suicide Neurospora, 1172 inactivator of succinate dehydrogenase, 3767 Neurotensin 4-Nitroquinoline Neurotensin: Immunohistochemical localization in rat central nervous Chemical transformation of rat cell infected with xenotropic type-C system, 4059 RNA virus and its suppression by virus-specific antiserum, 579 Neurotensin: Immunohistochemical localization in rat central nervous 4-Nitroquinoline-1-oxide system (correction), 5777 Partial inhibition of postreplication repair and enhanced frequency of Neurotensin: Specific binding to synaptic membranes from rat brain, chemical transformation in rat cells infected with leukemia virus, 238 1846 Nitrosoguanidine Neurotoxin a Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to Neurotoxin a from venom of Philippines sea snake: Three-dimensional ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 structure, 971 Nitrosoguanidine, N-methyl-N'-nitro-N- Neurotransmission Rejection by syngeneic mice of cell variants obtained by mutagenesis of Serotonergic neurons in peripheral nervous system: Identification in gut teratocarcinoma cell line, 272 by immunohistochemical localization of tryptophan hydroxylase, 3086 Nomenclature Neurotransmitter Nomenclature of phosphorus-containing compounds of biochemical Brain dopamine receptors: Detection with [3H]dihydroergocryptine, 3750 importance (Recommendations 1976), 2222 Heptadecapeptide gastrin in vagal nerve, 5707 Nonsense suppressor Regional dissociation of /-endorphin and enkephalin contents in rat Codon specificity of UGA suppressor tRNATrP from Escherichia coli, brain and pituitary, 5162 5496 Synaptic acetylcholine receptor sites identified in retina with Nonsense suppressors of yeast cause osmotic-sensitive growth, 305 peroxidase-labeled a-bungarotoxin, 3268 Norepinephrine Vasoactive intestinal polypeptide in brain: Localization in and release Brain dopamine receptors: Detection with [3H]dihydroergocryptine, 3750 from isolated nerve terminals, 3424 Calcitonin: Its hormonal action on gill, 4693 Neurovirulence Explant cultures of catecholamine-containing neurons from rat brain: Molecular basis of reovirus virulence: Role of S1 gene, 5744 Biochemical, histofluorescence, and electron microscopic studies, 4471 Neutralist-selectionist controversy Norepinephrine induces glial-specific enzyme activity in cultured glioma Polymorphism and subunit structure of enzymes: Neutralist-selectionist cells, 4501 controversy, 698 Norleucine, 6-diazo-5-oxo- Neutron scattering Affinity labeling of -y-glutamyl transpeptidase and location of -y-glutamyl Shape of 50S subunit of Escherichia coli ribosomes, 2316 binding site on light subunit, 931 Newcastle disease virus Normorphine Retinoic acid (vitamin A acid) induced transcriptional control of Neuronal actions of endorphins and enkephalins among brain regions: interferon production, 5382 Comparative microiontophoretic study, 2584 Newt North AmericanGreat Lakes see Pleurodeles waltlii Cyclonic mean circulation of large lakes, 2204 Newt limb Nuclearenvelope Bioelectricity and regeneration: Large currents leave stumps of Transformation by simian virus 40 induces virus-specific, related regenerating newt limbs, 4528 antigens in surface membrane and nuclear envelope, 2495 Niche space Nuclearmagnetic resonance Food webs and dimensionality of trophic niche space, 4533 see also Deuterium magnetic resonance; Proton magnetic resonance Nickel Adenylate kinase: 31p nuclear magnetic resonance kinetic measurements, Regulation of heme pathway enzymes and cellular glutathione content 3627 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5833

Asymmetric binding of the inhibitor di(adenosine-5') pentaphosphate Subunit structure of chromatin and organization of eukaryotic highly (ApsA) to adenylate kinase, 5355 repetitive DNA: Nucleosomal proteins associated with highly Biogenic amine-ionophore interactions: Structure and dynamics of repetitive mammalian DNA, 3297 lasalocid (X537A) complexes with phenethylamines and Nucleotide catecholamines in nonpolar solution, 4734 see also Cyclonucleotide; Polynucleotide structure Cholesterol and lanosterol: Differential effects on artificial membranes, Dinucleoside pyrophosphates are substrates for T4-induced RNA ligase, 4924 4839 ":C nuclear magnetic resonance studies of radiation damage: Nucleotide analog Radiation-induced degradation of glycine, 2394 Stereochemistry of polymerization by DNA-dependent RNA-polymerase 3C nuclear magnetic resonance study of five- and six-coordinated carbon from Escherichia coli: Investigation with a diastereomeric in nonclassical organometallic compounds: Dimeric trialkyl-, ATP-analogue (correction), 392 tricyclopropyl-, and triarylaluminums and some nido and closo Nucleotide binding site carboranes, 5217 4,4'-Bis(1-anilinonaphthalene 8-sulfonate): Probe of active site of Dynamic structure of whole cells probed by nuclear Overhauser myosin, 2334 enhanced nitrogen-15 nuclear magnetic resonance spectroscopy, 1988 Nucleotide, phosphorylated High-resolution 31P nuclear magnetic resonance studies of metabolism in Control of development: Isolation of Bacillus subtilis mutants blocked aerobic Escherichia coli cells, 888 early in sporulation and defective in synthesis of highly Hydrogen-bonded proton in tertiary structure of yeast tRNAPhe in phosphorylated nucleotides, 1125 solution, 1561 Nucleotide phosphotransferase Lecithin bimolecular leaflets: Nuclear magnetic resonance studies with Nucleotide phosphotransferase of Escherichia coli: Purification by incorporated fluorescent probes, 1032 affinity chromatography, 3226 Light-regulated permeability of rhodopsin:egg phosphatidylcholine Nucleotide phosphotransferase of Escherichia coli: Action on recombinant membranes, 5222 nicotinamide riboside and nicotinamide mononucleotide, 4160 Netropsin-poly(dA-dT) complex in solution: Structure and dynamics of Nucleotide sequence antibiotic-free base pair regions and those centered on bound see also Deoxyribonucleic acid sequence netropsin, 5207 Authentic /-globin mRNA sequences in homozygous /?-thalassemia, Nitrogen-15 nucldar magnetic resonance of aliphatic tripeptides, 1308 3047 Nonintercalative. binding of ethidium bromide to nucleic acids: Crystal Cleavage specificity of restriction endonuclease isolated from structure of ethidium-tRNA molecular complex, 4821 Haemophilus gallinarum (Hga I), 3213 Nuclear magnetic resonance studies of interaction of general anesthetics Covalent linkage of a protein to a defined nucleotide sequence at with 1,2-dihexadecyl-s'n-glycero-3-phosphorylcholine bilayer 5'-terminus of virion and replicative intermediate RNAs of poliovirus, (correction), 3621 961 31p nuclear magnetic relaxation studies of phosphocreatine in intact DNA sequencing with chain-terminating inhibitors, 5463 muscle: Determination of intracellular free magnesium, 4271 Molecular evolution of human and rabbit /1-globin mRNAs, 5618 mlpnuclear magnetic resonance measurements, of ATPase kinetics in Nucleic acid regulatory sequences: Computer analysis, 4401 aerobic Escherichia coli cells, 5551 Nucleotide sequence at 5' terminus of avian sarcoma virus genome, 1473 r3p nuclear magnetic resonance studies of Ehrlich ascites tumor cells, 87 Nucleotide sequence from a ribonuclease III processing site in 31P nuclear magnetic resonance studies of glycogen phosphorylase from bacteriophage T7 RNA, 822 rabbit skeletal muscle: Ionization states of pyridoxal 5'-phosphate, 856 Nucleotide sequence of 5' end of araBAD operon messenger RNA in Polypeptide synthesis initiated with various NH2-blocked Escherichia coli B/r, 49 aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5909 Nucleotide sequence of mutant eukaryotic gene: Yeast tyrosine-inserting Proton spin-lattice relaxation of' retinal rod outer segment membranes ochre suppressor SUP4-o, 5453 and liposomes of extracted phospholipids, 1978 Nucleotide sequence of 5' terminus of alfalfa mosaic virus RNA 4 leading Relative conformational rigidity in oxytocin and into coat protein cistron, 5504 [l1-penicillamine]oxytocin: Relationship of conformational flexibility to Nucleotide sequences near origin of replication of bacteriophage fl, 4219 peptide hormone agonism and antagonism, 1373 Nucleotide sequences of ribosome recognition sites in messenger RNAs Structure-function relations in phosphorylcholine-binding mouse of vesicular stomatitis virus, 3672 myeloma protein, 2109 Nucleotide sequences of untranslated 5' regions of human oe-and Nuclear Overhauser effect /-globin mRNAs, 5145 Dynamic structure of whole cells probed by nuclear Overhauser Nucleotide sequence surrounding a ribonuclease III processing site in enhanced nitrogen-15 nuclear magnetic resonance spectroscopy, 1988 bacteriophage T7 RNA, 984 31P nuclear magnetic relaxation studies of phosphocreatine in intact Origin of replication of colicin El plasmid DNA, 1865 muscle: Determination of intracellular free magnesium, 4271 pBR345 plasmid DNA: Origin of replication, 5265 Nucleic acid Sequence of oligonucleotide derived from 3' end of each of the four Ionic regulation in genetic translation systems, 1013 brome mosaic viral RNAs, 4900 Nucleic acid components: Ultraviolet resonant Raman spectroscopy, 2639 Structure of a large segment of genome of simian virus 40 that does not Selective recognition of nucleic acids by proteins: Specificity of guanine encode known proteins, 827 interaction with carboxylate ions, 4872 Structure of a large segment of genome of simian virus 40 that does Sequence specificity of mutagen-nucleic acid complexes in solution: not encode known proteins (correction), 2594 Intercalation and mutagen-base pair overlap geometries for proflavine Structure of promoter for T7 RNA polymerase, 4266 binding of dC-dC-dG-dG and dG-dG-dC-dC self-complementary 5'-Terminal nucleotide sequence of Escherichia coli lactose repressor duplexes, 2624 mRNA: Features of translational initiation and reinitiation sites, 4163 Nucleic acid denaturation Terminal redundancy and origin of replication of Rous sarcoma virus Analysis of single- and double-stranded nucleic acids on polyacrylamide RNA, 1908 and agarose gels by using glyoxal and acridine orange, 4835 5'-Terminal structures of poliovirion RNA and poliovirus mRNA differ Nucleolus only in genome-linked protein VPg, 5345 Gene regulation in Drosophila mulleri, D. arizonensis, and their hybrids: Numerical approximation Nucleolar organizer, 3498 Absorbing boundary conditions for numerical simulation of waves, 1765 Sequences homologous to ribosomal insertions occur in Drosophila Nutrition genome outside the nucleolus organizer, 4233 see also Diet Transcriptionally active chromatin isolated from mammalian nucleoli, 69 Size-mediated onset of genetically determined maturation in platyfish, Nucleoprotein Xiphophorus maculatus, 4547 Structure of histone Hi-DNA complex: Effect of histone H1 on DNA Zinc-binding ligands in milk and intestine: Role in neonatal nutrition? condensation, 4852 3547 Nucleoside kinase Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Role of nucleoside kinase(s), 5677 Obesity Nucleoside 5'-triphosphate Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich Replication of duplex DNA by bacteriophage T7 DNA polymrerase and in sucrose, 3038 gene 4 protein is accompanied by hydrolysis of nucleoside Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich 5'-triphosphates, 1525 in sucrose (correction), 3550 Nucleosome Octopine Chromatin subunits from baker's yeast: Isolation and partial Thermosensitive step associated with transfer of Ti plasmid during characterization, 1343 conjugation: Relation to transformation in crown gall, 2848 Comparative subunit structure of HeLa, yeast, and chicken erythrocyte Oecophylla longinoda chromatin, 79 Colony-specific territorial pheromone in African weaver ant Oecophylla Crosslinked histone octamer as model of nucleosome core, 2780 longinoda (Latreille), 2072 Crosslinked histone octamer as model of nucleosome core (correction), Okazaki fragment 5198 Transient accumulation of Okazaki fragments as a result of uracil Histone H3 disulfide dimers and nucleosome structure, 5519 incorporation into nascent DNA, 154 Human mitotic chromosomes: Higher-order structure, 1595 Oleoylphosphate Involvement of histone H1 in organization of chromosome fiber, 1879 Fi-ATPase-catalyzed synthesis of ATP from oleoylphosphate and ADP, Physical properties of chemically acetylated rat liver chromatin, 3244 4919 Protein A24 in rat liver nucleosomes, 5492 Oligomycin Selective association of trout-specific H6 protein with chromatin regions Location of protein(s) involved in oligomycin-induced inhibition of susceptible to DNase I and DNase II: Location of HMG-T in spacer mitochondrial adenosinetriphosphatase near outer surface of inner region between core nucleosomes, 2810 membrane, 4185 Downloaded by guest on September 27, 2021 5834 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Oligonmycin-dependent ionophoric protein subunit of mitochondrial fragment of lac regulatory region in M13 replicative form in vitro, adenosinetriphosphatase, 4306 3642 Oligonucleotide synthesis /-Galactosidase of Escherichia coli: Amino acid sequence, 1507 Ellzymatic synthesis of oligonucleotides of defined sequence: Synthesis 5'-Terminal nucleotide sequence of Escherichia coli lactose repressor of segment of yeast iso- I-cytochrome c gene, 96 mRNA: Features of translational initiation and reinitiation sites, 4163 Oligosaccharide Operon, leucine Conmparative rates of transfer of lipid-linked oligosaccharides to Functional expression of cloned yeast DNA in Eschoerichia coli, 487 endclogenoutis glycoprotein acceptors in vitro, 4411 Operon, ribosomal ribonucleic acid Oligosaccharides in humano IgAl and IgA2 immtunoglobulins: Location Identification of spacer tRNA genes in individtual ribosomal RNA and strtuctrural significance, 2301 transcription units of Escherichia coli, 2710 Oligosaccharide-lipid Identification of spacer tRNA genes in individual ribosomal RNA Enrzynmatic conversion of proteins to glycoproteins, 134 transcription units of Escherichia coli (correction), 4706 Oligouridylate Operon, trp Oligoturidylate stretches in heterogeneous nuclear RNA, 2217 Nucleic acid regulatory sequences: Computer analysis, 4401 Oncornavirus Transcription termination at trp, operon attenuators of Escherichia coli see also Ribonucleic acid tumor virus and Salmonella typhimurium: RNA secondary strtucture and Anmtigemniccrossreactivity to RD114 p30 protein, expressed in a human regulation of termination, 4365 fil)rosarcomna cell line, 744 Opiate Antigenic relatedness of DNA polymerase of human breast cancer see also Receptor, opiate; specific opiates particles to enzyme of Mason-Pfizer monkey virus, 2144 Biologically active conformation of opiates and enkephalin, 5179 I)NA polymerase of human breast camncer particles: Purification and Effects of naloxonoeon experimentally induced ischemic pain and on characterization, 764 mood in human subjects, 1291 EIvolution of primate oncornaviruses: Emndogenous virus from langurs /-Endorphin: Pituitary and adrenoalglands modulate its action, 4628 (Presbytis spp.) with related virogene sequences in other Old World In vitro biosynthesis of /-endorphin, y-lipotropin, and /1-lipotropin by moonkeys, 4557 pars intermedia of beef pituitary glands, 4276 Single-stranded DNA from oncornavirus-infected cells enriched in Neuronal actions of endorphins and enkephalins among brain regionls: virtus-specific DNA sequences, 3720 Comparative microiontophoretic study, 2584 Ontogenesi. Opiate-dependent modutlation of adenylate cyclase, 3365 How to label nerve cells so that they can interconnect in an ordered Regional dissociation of 13-endorphinamnd enkephalin contents in rat tashionr, 5176 brain and pituitary, 5162 Oocyte Opiate-like peptide see also Egg, fish Conformation of /-etndorphin and /-lipotropin: Formation of helical H-ligh-fidelity transcription of 5S DNA injected into Xenlopus oocytes, structure in methanol and sodium dodecyl stulfate solutions, 3235 2064 /-Endorphin: In vitro biosynthesis in pituitary glands, 1403 Oocyte, amphibian /1-Endorphin: Stimulation of growth hormone release in vivo, 358 Getne activation in somatic nuclei after injection into amphibian oocytes, Opiate peptides synthesized by a clonal pituitary tumor cell line, 2259 2470 Opiate peptide Oocyte, mammalian /-Lipotropin: Localization of cells and axons in rat brain by Changes in pattern of protein synthesis during meiotic maturation of immunocytochemistry, 5155 mioamomnalianoocytes in vitro, 538 Opiliones Oocyte, Strongylocentrotus purpuratus Characterization and synthesis of volatile compounds for defensive Release of ovoperoxidase from sea urchin eggs hardens fertilization secretions of "daddy longlegs" (Arachnida: Opiliones: Leiobunuum mnembrane with tyrosiie crosslinks, 4214 spp.), 419 Oocyte, Xenopus laevis Opioid peptide Frog oocytes synthesize and completely process precursor polypeptide to Isolation and characterization of opioid peptides from rat pituitary: virioIn structural proteins after microinjection of avian myeloblastosis /1-Lipotropin, 3052 virtus RNA, 3230 Isolation and characterization of opioid peptides from rat pituitary: Indtuctionm and decay of human fibroblast interferon mRNA, 441.5 /-Endorphin, 4969 Inoterf'eroonmessenger RNA content of human fibroblasts during Optical activity inductiono, shutoff, and superinoduction of interferon production, 3409 Circular dichroism of adenosiine dinucleotides, 1785 Interferoon production and interferon messenger RNA' synthesis in Optical diffraction human fibroblasts, 1.483 Electron microscopy of fibers and discs of hemoglobin S having sixfold Ionic requirements for induction of maturation (meiosis) in full-grown symmetry, 5538 anod nmeditum-sized Xenopus laevis oocytes, 3461 Optical phenomena mRNA-directed synthesis of catalytically active mouse /-glucuronidase Quantum statistical theory of optical phenomena, 31,05 in Xenopus oocytes, 4462 Optic lobe Purified DNAs are transcribed after microinjection into Xenopus Mutual entrainment of bilaterally distributed circadian pacemakers, oocytes, 1.502 1277 Synvthesis of human interferon by Xenopus laevis oocytes: Two Optic system strtuctural genes for interferons in human cells, 3287 Specific projection of displaced retinal ganglion cells upon accessory 'Tadpole and adult globin RNA sequences in oocytes of Xenopus laevis, optic system in pigeon (Columbia livia), 1753 3835 Orbital, hybrid Oogenesis see also Molecular orbital T'adpole amndadult globin RNA sequences in oocytes of Xenopus laevis, Structure of transition-metal cluster compounds: Use of additional 3835 orbital resulting from f, g character of spd bond orbitals, 5235 Operator, commutator Organ culture Caulchy integrals on Lipschitz curves and related operators, 1324 Hormone-inducible casein messenger RNA in serum-free organ culture Operator, lac of whole mammary gland, 2441 Binding of synthetic lactose operator DNAs to lactose repressors, 3292 Organometallic compound (Conrtacts between lac repressor and thymines in lac operator, 4973 13C nuclear magnetic resonance study of five- and six-coordinated carbon Minimal length of lactose operator sequence for specific recognition by in nonclassical organometallic compoumnds:Dimeric trialkyl-, lactose repressor, 966 tricyclopropyl-, and triarylaluminums and some nido and closo Operator, Lewy carboranes, 5217 Class of counterexamples to the integrability problem, 2655 Ornithine aminotransferase Operator, maximal see Ornithine-oxo-acid aminotransferase Equivalence between boundedness of certain classes of maximal and Ornithine decarboxylase (EC 4.1.1.17) multiplier operators in Fourier analysis, 423 Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic Operator, multiplier GMP from indtuction of ornithine decarboxylase by tumor promoter Equivalence between boundedness of certain classes of maximal and 12-0-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo, 657 multiplier operators in Fourier analysis, 423 Dissociation of tumor promoter-stimulated ornithine decarboxylase Operator, pseudomonotone activity and DNA synthesis in mouse epidermis in vivo and in vitro by Pseudo-monotone operators and nonlinear elliptic boundary value fluocinolone acetonide, a tumor-promotion inhibitor, 3908 problems on unbounded domains, 2659 Enzyme regulation in neuroblastoma cells in a salts/glucose medium: Operator, symmetric Induction of ornithine decarboxylase by asparagine and glutamine, 'Iheory of connectivity for f'ormally symmetric operators, 4722 3791 Operon Nerve growth factor increases activity of ornithine decarboxylase in see also Gene superior cervical ganglia of young rats, 4681 Operon, araBAD Ornithine-oxo-acid aminotransferase (EC 2.6.1.13) Nucleotide sequence of 5' end of araBI3ADoperon messenger RNA in Gyrate atrophy of choroid and retina: Deficiency of ornithine Escherichia coli B/r, 49 aminotransferase in transformed lymphocytes, 5159 Operon, galactose Orthophosphate Nucleotidle sequence of operator-promoter region of galactose operon of Complexes of inorganic pyrophosphate, orthophosphate, and calcium as Escherichia coli, 106 stimulants of 3T3 cell multiplication, 5026 Operon, histidine Oryzias latipes Ftotnctionalexpression of cloned yeast DNA in Escherichia coli, 487 Free calcium increases explosively in activating medaka eggs, 623 Operon, lac Oscillatoria limnetica Filamoentous coliphage M13 as cloning vehicle: Insertion of HindlI Quantum yields for oxygenic and anoxygenic photosynthesis in cyanobacterium Oscillatoria limnetica, 2152 Downloaded by guest on September 27, 2021 Proc. 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Osmium Paleobiology Structure of transition-metal cluster compounds: Use of adlditional Is evolution gradual or rectangular? Evidence from living fishes, 5083 orbital resulting from f, g character of spd bond orbitals, 5235 Paleontology Osteopetrosis How does selection reconcile individual advantage with the good of the Immunological defect and its correction in osteopetrotic mutant rat, 339 group? 4542 Ouabain Palindrome Abnormal lithium and sodium transport in erythrocytes of manic patient Location of palindromes in immunoglobulin genes, 2526 and some members of his family, 3607 Pancreas Amino-acid transport into Ehrlich cells: Unexpected additional mode of see also Cell, pancreatic; Islets of Langerhans energization, 1488 Pancreatic immunoreactive somatostatin release, 2140 Cystic fibrosis fibroblasts: Increased resistance to ouabain toxicity, 1676 Post-translational cleavage of presecretory proteins with extract of rough Increased dexamethasone resistance of cystic fibrosis fibroblaEsts,5642 microsomes from dog pancreas containing signal peptidase activity, Mutagenesis in S49 mouse lymphoma cells: Induction of resistance to 5598 ouabain, 6-thioguanine, and dibutyryl cyclic AMP, 679 Transplantable insulinoma in rat, 628 Roles of proteins from inner face of plasma membranes in susceptibility Pantetheine of (Na+ + K+)-stimulated Mg2+ adenosinetriphosphatase to ouabain, Isolation of amino acid activating subunit-pantetheine protein 633 complexes: Role in chain elongation in tyrocidine synthesis, 2343 Ovary Papillomavirus, bovine Ovarian "inhibin": Suppression of secondary rise in serum follicle Bovine papilloma virus: Virus-specific DNA sequences in naturally stimulating hormone levels in proestrous rats by injection of porcine occurring equine tumors, 524 follicular fluid, 5721 Paramyxovirus Proteolytic enzyme activation of rat ovarian adenylate cyclase, 4857 Variation in ability of measles virus plaque progeny to induce inoterferon, Oxidation 3056 Mechanism of oxidation of tryptophan to formylkynurenine--25 years Parathyrin later, 4730 Dopaminergic stimulation of cyclic AMP accumulation and parathyroid Oxidativedenaturation hormone release from dispersed bovine parathyroid cells, 4210 Ligands and oxidants in ferrihemochrome formation and oxicdative Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic hemolysis, 2556 GMP in rat renal cortex: Effect of parathyroid hormone, 3569 Oxidativephosphorylation Parathyroidhormone Fi-ATPase-catalyzed synthesis of ATP from oleoylphosphate and ADP, see Parathyrin 4919 Parenchyma H+/ATP ratio during ATP hydrolysis by mitochondria: Modifications of Organic acid and potassium accumulation in guard cells during stomatal chemiosmotic theory, 1955 opening, 4434 Location of protein(s) involved in oligomycin-induced inhibition of Parkinsonism mitochondrial adenosinetriphosphatase near outer surface of inner Dopamine-dependent adenylate cyclase: Quantitative correlation with membrane, 4185 responses to levodopa in various mice, 1242 Oligomycin-dependent ionophoric protein subunit of mitochondrial L-3,4-Dihydroxyphenylalanine-induced hypersensitivity simulating adenosinetriphosphatase, 4306 features of denervation, 2126 Oxoglutaratedehydrogenase (EC 1.2.4.2) Parkinson's disease Acyl group and electron pair relay system: Network of interacting lipoyl Opposing effects of dopaminergic to cholinergic compounds on cerebral moieties in pyruvate and ac-ketoglutarate dehydrogenase complexes dopamine-activated adenylate cyclase, 769 from Escherichia coli, 4223 Parotid gland Oxolinicacid Luminal membrane retrieved after exocytosis reaches most Golgi Mechanism of action of nalidixic acid: Purification of Escherichia coli cisternae in secretory cells, 5073 nalA gene product and its relationship to DNA gyrase and a Pars intermedia nicking-closing enzyme, 4767 In vitro biosynthesis of /-endorphin, y-lipotropin, and f-lipotropin by Nalidixic acid resistance: A second genetic character involved in DNA pars intermedia of beef pituitary glands, 4276 gyrase activity, 4772 Parthenogenesis 6(9)-Oxy-11,15-dihydroxyprosta-7,13-dienoicacid Evolutionary consequences of parthenogenesis: Evidence from the Novel prostaglandin is major product of arachidonic acid metabolism in Warramaba virgo complex, 1130 rabbit heart, 101 Particle,charged Oxygen Minimal coupling and symplectic mechanics of a classical particle in see also Electrophilic oxygen donation presence of Yang-Mills field, 5253 Oxygen intermediates and mixed valence states of cytochrome oxidase: Partition function Infrared absorption difference spectra of compounds A, B, and C of Single partition function for three phases, 2598 cytochrome oxidase and oxygen, 4777 Parvalbumin Oxygen "pulsed" cytochrome c oxidase: Functional properties and Unfolding and refolding occur much faster for a proline-free protein than catalytic relevance, 3128 for most proline-containing proteins, 4178 Source of oxygen in CO2 produced in bioluminescent oxidation of firefly Pea luciferin, 2799 see Pisum sativum Oxygenaffinity Pea enation mosaicvirus 5'-Deoxypyridoxal as a potential anti-sickling agent, 1721 Replication of pea enation mosaic virus RNA in isolated pea nuclei, 2919 Erythrocyte sickling inhibited in vitro by DL-glyceraldehyde, 367 Penicillin Ligand kinetics of hemoglobin S containing erythrocytes, 203 Mutants of Escherichia coli lacking in highly penicillin-sensitive Oxygen binding D-alanine carboxypeptidase activity, 2976 Energy-structure correlation in metalloporphyrins and control of oxygen Penicillin-binding peptide isolated from D-alanine carboxypeptidase of binding by hemoglobin, 1789 Bacillus subtilis, 1009 Native human hemoglobin reconstituted from separated globin chains Simultaneous deletion of D-alanine carboxypeptidase IB-C and and alloplex intermediates, 64 penicillin-binding component IV in mutant of Escherichia coli K12, Tertiary structural change in hemoglobin: Mechanism, 801 2980 Thermodynamic aspects of linkage between binding of chloride and Thermosensitive mutation in Escherichia coli simultaneously causing oxygen to human hemoglobin, 4135 defects in penicillin-binding protein-lBs and in enzyme activity for Oxygen,di-, reduction peptidoglycan synthesis vitro, 5472 Synthesis and characterization of "face-to-face" porphyrins, 18 Transition state structures of dipeptide related to mode of action of Oxyhemoglobin /-lactam antibiotics, 5239 Magnetic properties of oxyhemoglobin, 398 Pentitol phosphate Oxyhemoglobin: Magnetic properties and structure, 2612 Metabolism of pentitols: New pathway, 4296 Oxytocin Pentobarbital Neurophysin biosynthesis in normal rats and in rats with hereditary Ovarian "inhibin": Suppression of secondary rise in serum follicle diabetes insipidus, 4046 stimulating hormone levels in proestrous rats by injection of porcine Relative conformational rigidity in oxytocin and follicular fluid, 5721 [l1-penicillamine]oxytocin: Relationship of conformational flexibility to Peptide peptide hormone agonism and antagonism, 1373 see also Cyanogen bromide peptide Oxytricha Peptide antibiotic Gene-sized DNA molecules of Oxytricha macronucleus have the same Biological function of gramicidin: Selective inhibition of RNA terminal sequence, 4325 polymerase, 1478 Ozone-oxygenmixture Peptide biosynthesis Significant structure theory applied to phase separation, 10 Translation of melittin messenger RNA in vitro yields a product Pachygrapsuscrassipes Randall terminating with glutaminylglycine rather than with glutaminamide, Secretion of a-ecdysone by crab Y-organs in vitro, 615 975 Peptide, chemotactic Specific receptor sites for chemotactic peptides on human Pain polymorphonuclear leukocytes, 1204 Effects of naloxone on experimentally induced ischemic pain and on Peptide conformation mood in human subjects, 1291 Enkephalin: Conformational analysis by empirical energy calculations, Immunohistochemical analysis of peptide pathways possibly related to 414 pain and analgesia: Enkephalin and substance P, 3081 Downloaded by guest on September 27, 2021 5836 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Peptide, 3-electroencephalogram-inducing Phorbol diester Delta-electroencephalogram(-sleep)-inducing peptide: Characterization, Tumor promoters inhibit spontaneous differentiation of Friend 1282 erythroleukemia cells in culture, 2894 Peptide, gastrointestinal-like Phormia regina Cholecystokinin and its COOH-terminal octapeptide in pig brain, 3035 Behavior-genetic analysis of Phormia regina: Conditioning, reliable Immunohistochemical localization in rabbit brain of a peptide individual differences, and selection, 5193 resembling COOH-terminal octapeptide of cholecystokinin, 3033 Phosphatase Peptide initiation Phosphorylation of smooth muscle myosin affects actin activatioin and Peptide initiation: Partial reaction inhibited by phosphorylation of Ca2+ regulation, 129 either initiation factor eIF-2 or 40S ribosomal proteins, 1445 Phosphate Peptide map Calcitonin: Its hormonal action on gill, 4693 Actin microheterogeneity in chick embryo fibroblasts, 120 Polypeptide synthesis initiated with various NH2-blocked Peptide synthesis aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5909 see also Protein synthesis Phosphatidylcholine Activation of lipoprotein lipase by native and synthetic fragments of Immunogenicity of liposomal model membranes in mice: Dependence on human plasma apolipoprotein C-II, 4848 phospholipid composition, 1234 Enzymes as reagents in peptide synthesis: Enzyme-labile protection for Light-regulated permeability of rhodopsin:egg phosphatidylcholilne carboxyl groups, 2739 recombinant membranes, 5222 Internal structural controls for evaluation of inactive synthetic peptide Lipid-protein interaction in phosphatidylcholine exchange protein, 1807 analogs: Synthesis of [Ornl3,14]apamin and its guanidination to an Phosphatidylcholine, L-a-didecanoyl- apamin derivative with full neurotoxic activity, 2771 Interaction of L-a-didecanoyl phosphatidylcholine with Al polypepticle Isolation of amino acid activating subunit-pantetheine protein of high density lipoprotein, 3796 complexes: Role in chain elongation in tyrocidine synthesis, 2343 Phosphatidylethanolamine Semisynthetic cytochrome c, 4248 Rapid transmembrane movement of newly synthesized phospholipids Synthesis of a 19-residue peptide with alamethicin-like activity, 115 during membrane assembly, 1821. Synthetic peptides with biological activities and specificity of human Phosphatidylserine synthase (EC 2.7.8.8) C3a anaphylatoxin, 1826 Gene cloning for isolation of enzymes of membrane lipid synthesis: Peptidoglycan Phosphatidylserine synthase overproduction in Escherichia coli, 141.2 Enhancement of nonspecific immunity to Klebsiella pneumoniae Phosphocholine infection by a synthetic immunoadjuvant Antigen-binding mutants of mouse myeloma cells, 5687 (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs, 2089 Phosphocreatine Mutants of Escherichia coli lacking in highly penicillin-sensitive 3iP nuclear magnetic relaxation sttudies of phosphocreatine in intact D-alanine carboxypeptidase activity, 2976 muscle: Determination of intracellular free magnesium, 4271 Thermosensitive mutation in Escherichia coli simultaneously causing Phosphodiesterase I (EC 3.1.4.1) defects in penicillin-binding protein-IBs and in enzyme activity for Light-activated GTPase in vertebrate photoreceptors: Regulation of peptidoglycan synthesis vitro, 5472 light-activated cyclic GMP phosphodiesterase, 4238 Pericardial organ Phosphoglucose isomerase Effect of increased potassium concentrations on particle motion within a see Glucosephosphate isomerase neurosecretory structure, 5759 Phospholipase A2 (EC 3.1.1.4) Peroxidase Dual role of interfacial phospholipid in phospholipase A2 catalysis, 1950 Localization of motor neuron pools supplying identified muscles in Evidence against phospholipid asymmetry in intracelltular membranoes normal and supernumerary legs of chick embryo, 3582 from liver, 3350 Release of ovoperoxidase from sea urchin eggs hardens fertilization Phospholipase C (EC 3.1.4.3) membrane with tyrosine crosslinks, 4214 Membrane ultrastructural changes during calcium phosphate-induced Synaptic acetylcholine receptor sites identified in retina with fusion of human erythrocyte ghosts, 2417 peroxidase-labeled (r-bungarotoxin, 3268 Phospholipid Peroxidase (EC 1.11.1.7) Biological properties of poliovirus encapsulated in lipid vesicles: Pressure affects visible spectra of complexes of myoglobin, hemoglobin, Antibody resistance and infectivity in virus-resistant cells, 3471 cytochrome c, and horse radish peroxidase, 1 Biosynthesis of covalently linked diglyceride in murein lipoprotein of' Specific projection of displaced retinal ganglion cells upon accessory Escherichia coli, 531.8 optic system in pigeon (Columbia livia), 1753 Dual role of interfacial phospholipid in phospholipase A2 catalysis, 1950 Ultrastructural localization of cell membrane GM1ganglioside by cholera Endocytosis: Response to altered fatty acyl composition of macrophage toxin, 3782 phospholipids, 4895 Uterine peroxidase as marker for estrogen action, 3162 Evidence against phospholipid asymmetry in intracellular membranes pH fromnliver, 3350 see Intracellular pH Gene clonimngfor isolation of enzymes of membrane lipid synthesis: Phagocytosis Phosphatidylserine synthase overproduction in Escherichia coli, 1412 Changes in membrane microviscosity associated with phagocytosis: Glycerophospholipid synthesis: Improved general method and new Effects of colchicine, 1072 analogs containing photoactivable groups, 4315 Endocytosis: Response to altered fatty acyl composition of macrophage Immunogemnicityof liposomal model membranes in mice: Dependence on phospholipids, 4895 phospholipid composition, 1234 Phagosome Interaction of 1-o-didecanoyl phosphatidylcholine with Al polypeptide Transmembrane bridging proteins identified in plasma membrane of of high density lipoprotein, 3796 cultured mouse L cells, 5341 Membrane ultrastructural changes during calcium phosphate-induced Phalloidin fusion of htuman erythrocyte ghosts, 2417 Phalloidin-induced actin polymerization in cytoplasm of cultured cells Proton spin-lattice relaxation of retinal rocdouter segment membranes interferes with cell locomotion and growth, 5613 and liposomes of extracted phospholipids, 1978 Phase separation Rapid transmembrane movement of newly synthesized phospholipids Significant structure theory applied to phase separation, 10 during membrane assembly, 1821 Phase transition Phosphoprotein Enzyme-enzyme interactions affect steady-state enzyme kinetics, 4111 Phosphohexosyl components of a lysosomal enzyme are recognize(d by Single partition function for three phases, 2598 pinocytosis receptors on human fibroblasts, 2026 Theoretical study of effect of enzyme-enzyme interactions on Phosphorescence steady-state enzyme kinetics, 3632 Radiationless relaxation in "large" molecules: Preparation of true "Virial" expansion of enzyme flux and use of quasi-chemical molecular eigenstates and Born-Oppenheimer states by a coherent approximation for two-state enzymes with enzyme-enzyme light source, 1310 interactions, 5227 Phosphorus Phenacemide Nomenclature of phosphorus-containing compounds of biochemical Ethylphenacemide amndphenacemide: Conformational similarities to importance (Recomnmendations 1976), 2222 diphenylhydantoin and stereochemical basis of anticonvulsant activity, Phosphorylase kinase 1264 Activation of hormone-sensitive lipase and phosphorylase kinase by Phenethylamine purified cyclic GMP-dependent protein kinase, 484:3 Biogenic amine-ionophore interactions: Structure and dynamics of Phosphorylcholine lasalocid (X537A) complexes with phenethylamines and Structure-function relations in phosphorylcholine-binding motuse catecholamines in nonpolar solution, 4734 myeloma protein, 2109 Phenobarbital Photobleaching recovery Translation in vitro of rat liver messenger RNA coding for ligandin Receptor diffusion on cell surfaces modulated by locally bound (glutathione S-transferase B), 1899 concanavalin A, 1110 Pheochromocytoma Photocell Cholinergic metabolism and synapse formation by a rat nerve cell line, n-Type Si-based photoelectrochemical cell: Iliquid junction photocell 2579 using a nonaqueous ferricenium/ferrocene electrolyte, 4116 Pheromone Photoelectric signal Colony-specific territorial pheromone in African weaver ant Oecophylla Rhodopsin in model membranes: Charge displacements in interfacial longinoda (Latreille), 2072 layers, 207 Phloretin Photoelectric spectrophotometry Abnormal lithium and sodium transport in erythrocytes of manic patient Chemical compositions of Magellanic Clouds' HII regions based ron and some members of his family, 3607 photoelectric spectrophotometry, 5203 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5837

Photoelectrochemistry Transport of a-amylase across basolateral membrane of pancreatic n-Type Si-based photoelectrochemical cell: Liquid junction photocell acinar cell, 4068 using a nonaqueous ferricenium/ferrocene electrolyte, 4116 Phytochrome Photoelectronspectroscopy 12I-labeled phytochrome used to quantitate phytochrome binding to Detailed electronic description of triple bonds between transition metal membranes of Avena sativa, 4439 atoms and verification by photoelectron spectroscopy, 31.09 Phytohemagglutinin Photolysis,flash Erythropoietin: Isolation by affinity chromatography with lectin-agarose Kinetics of hemoglobin-carbon monoxide reactions measured with a derivatives, 4633 superconducting magnetometer: Method for fast reactiomnsin solution, Gyrate atrophy of choroid and retina: Deficiency of ornithine 2620 aminotransferase in transformed lymphocytes, 5159 Photooxygenation Kinetics of cell death and disintegration in human lymphocyte cultures, Mechanism of oxidation of tryptophan to formylkynurenine--25 years 2536 later, 4730 Low-molecular-weight peptide inhibits RNA synthesis in human Photoperiodism leukemic and phytohemagglutinin-stimulated leukocytes and globin Promotion and inhibition of flower formation in a dayneutral plant in mRNA transcription in differentiating Friend cells, 3869 grafts with a short-day plant and a long-day plant, 2412 Picolinic acid Photoreceptor Control of growth by picolinic acid: Differential response of normal and Light-activated GTPase in vertebrate photoreceptors: Regulation of transformed cells, 2889 light-activated cyclic GMP phosphodiesterase, 4238 Picornavirus Photosynthesis Poliovirus-specific primer-dependent RNA polymerase able to copy Electron paramagnetic resonance studies of photosynthetic electron poly(A), 3677 transport: Photoreduction of ferredoxin and membrane-bound Pig iron-sulfur centers, 3826 Cultured aortic endothelial cells from pigs with von Willebrand disease: Light collection and harvesting processes in bacterial photosynthesis In vitro model for studying molecular defect(s) of the disease, 5702 investigated on picosecond time scale, 1997 Pigeon Quantum efficiency of photosynthetic energy conversion, 3377 see Columbia livia Quantum yields for oxygenic and anoxygenic photosynthesis in Pineal gland cyanobacterium Oscillatoria limnetica, 2152 Pineal protein phosphorylation during serotonin N-acetyltransferase Selective enrichment of photosynthetic electron transport mutants, 610 induction, 1928 Tripartite model for photochemical apparatus of green plant Pinocytosis photosynthesis, 3382 Endocytosis: Response to altered fatty acyl composition of macrophage PhotosystemI phospholipids, 4895 Quantum yields for oxygenic and anoxygenic photosynthesis in Phosphohexosyl components of a lysosomal enzyme are recognized by cyanobacterium Oscillatoria limnetica, 2152 pinocytosis receptors on human fibroblasts, 2026 Selective enrichment of photosynthetic electron transport mutants, 610 Piperidine Phycobiliprotein Method for sequencing DNA, 560 Cyanobacterial phycobilisomes: Molecular composition, 1635 Pisum sativum Phycobilisome Replication of pea enation mosaic virus RNA in isolated pea nuclei, 2919 Cyanobacterial phycobilisomes: Molecular composition, 1635 Pituitary Physarumpolycephalum see also Cell, pituitary Extracellular inducer of asexual plasmodium formation in Physarum Action potentials occur in cells of normal anterior pituitary gland and polycephalum, 1120 are stimulated by hypophysiotropic peptide thyrotropin-releasing Physics hormone, 4064 see also Applied Physical and Mathematical Sciences Corticotropin in brain of normal and hypophysectomized rats, 648 Crystallography of new ternary borides, 1336 /-Endorphin: In vitro biosynthesis in pituitary glands, 1403 Crystallography of new ternary borides (correction), 3621 /-Endorphin: Pituitary and adrenal glands modulate its action, 4628 Direct observations of atomic diffusion by scanning transmission Glucocorticoid effect on level of corticotropin messenger RNA activity in electron microscopy, 1802 rat pituitary, 3283 Electromagnetism and gravitation, 2664 In vitro biosynthesis of /-endorphin, ^-lipotropin, and /-lipotropin by Gravitational interaction of hadrons: Band-spinor representations of pars intermedia of beef pituitary glands, 4276 GL(n,R),4157 Isolation and characterization of opioid peptides from rat pituitary: High superconducting transition temperatures of new rare earth ternary /-Lipotropin, 3052 borides, 1334 Isolation and characterization of opioid peptides from rat pituitary: Microscopic theory of irreversible processes, 4152 /-Endorphin, 4969 Minimal coupling and symplectic mechanics of a classical particle in Opiate peptides synthesized by a clonal pituitary tumor cell line, 2259 presence of Yang-Mills field, 5253 Regional dissociation of /-endorphin and enkephalin contents in rat Random walks and generalized master equations with internal degrees of brain and pituitary, 5162 freedom, 430 Triiodothyronine stimulates specifically growth hormone mRNA in rat Physiological Sciences pituitary tumor cells, 2054 Abnormal lithium and sodium transport in erythrocytes of manic patient Placenta and some members of his family, 3607 Histaminase (diamine oxidase) activity in human tumors: Expression of Action potentials occur in cells of normal anterior pituitary gland and a mature genome, 883 are stimulated by hypophysiotropic peptide thyrotropin-releasing Plagiodera versicolora hormone, 4064 Methylcyclopentanoid terpenes from larval defensive secretion of a Adsorption inhibition as mechanism of freezing resistance in polar fishes, chrysomelid beetle (Plagiodera versicolora), 2189 2589 Plagiolactone Aplysia californica: Development of nervous system, 375 Methylcyclopentanoid terpenes from larval defensive secretion of a Calcitonin: Its hormonal action on gill, 4693 chrysomelid beetle (Plagiodera versicolora), 2189 Calcium modulation in brain extracellular microenvironment Plancherel theorem demonstrated with ion-selective micropipette, 1287 Explicit Plancherel theorem for ground state representation of Calcium translocation by Golgi and lateral-basal membrane vesicles from Heisenberg chain, 816 rat intestine: Decrease in vitamin D-deficient rats, 3612 Plasma Carcass components at first estrus of rats on high-fat and low-fat diets: DNA synthesis induced in BALB/c 3T3 cells by serum components: Body water, protein, and fat, 379 Reevaluation of commitment process, 4481 Centers involved in autonomic reflex reactions originating from High-molecular-weight kininogen: Role in surface-binding and activation stretching of the atria, 2177 of coagulation Factor XI and prekallikrein, 4636 Conformational requirements for dopamine-induced vasodilation, 3602 Method of computational magnetohydrodynamics defining stable Scyllac 3':5'-Cyclic AMP and hormonal control of puparium formation in fleshfly equilibria, 393 Sarcophaga bullata, 2182 Thymopoietin and thymic hormone levels in human plasma: Bioassay Delta-electroencephalogram(-sleep)-inducing peptide: Characterization, determinations, 2541 1282 Plasmacytoma Effect of MgATP on stiffness measured at two frequencies in Amino acid sequence of precursor region of MOPC-315 mouse Ca2+-activated muscle fibers, 4073 immunoglobulin heavy chain, 5692 Formation of lung surfactant films from intact lamellar bodies, 3617 Plasmid Interaction of myogenic and neurogenic mechanisms that control heart Aminoglycoside-modifying enzyme of antibiotic-producing bacterium rate, 1761 acts as determinant of antibiotic resistance in Escherichia coli, 999 Lithium efflux through Na/K pump in human erythrocytes, 3099 Nucleic acid reassociation kinetics: Retarded rate of hybridization of Modulation of acetylcholine receptor by antibody against receptor, 3090 RNA with excess DNA, 2306 Mutual entrainment of bilaterally distributed circadian pacemakers, Replication and expression of plasmids from Staphylococcus aureus in 1277 Bacillus subtilis, 1680 Mysterious form of referred sensation in man, 4702 Site-specific genetic recombination promoted in vivo by EcoRI Neuronal actions of endorphins and enkephalins among brain regions: restriction endonuclease, 4811 Comparative microiontophoretic study, 2584 Translation of Drosophila melanogaster sequences in Escherichia coli, Reduction of pore area of avian eggshell as adaptation to altitude, 3095 5041 Role of ecdysone, pupariation factors, and cyclic AMP in formation and Plasmid ColEl tanning of puparium of fleshfly Sarcophaga bullata, 4697 Deletions affecting transposition of antibiotic resistance gene, 702 Site of water vapor absorption in desert cockroach, Arenivaga Functional expression of cloned yeast DNA in Escherichia coli, 487 investigata, 1757 Gene cloning for isolation of enzymes of membrane lipid synthesis: Downloaded by guest on September 27, 2021 5838 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Phosphatidylserine synthase overproduction in Escherichia coli, 1412 Pokeweedmitogen Identification of spacer tRNA genes in individual ribosomal RNA Pure and mixed eyrthroid colony formation in vitro stimulated by spleen transcription units of Escherichia coli, 2710 conditioned medium with no detectable erythropoietin, 3879 Identification of spacer tRNA genes in individual ribosomal RNA Poliovirus transcription units of Escherichia coli (correction), 4706 Biological properties of poliovirus encapsulated in lipid vesicles: Mechanism of genetic recombination: Maturation of recombination Antibody resistance and infectivity in virus-resistant cells, 3471 intermediates, 4168 Covalent linkage of a protein to a defined nucleotide sequence at Origin of replication of colicin El plasmid DNA, 1865 5'-terminus of virion and replicative intermediate RNAs of poliovirus, Plasmid, F' 961 A gene from Escherichia coli affecting the sigma factor subunit of RNA Poliovirus-specific primer-dependent RNA polymerase able to copy polymerase, 1836 poly(A), 3677 Chromosomal location of structural gene for RNA polymerase c-factor in Protein covalently linked to poliovirus genome RNA, 59 Escherichia coli, 1831 5'-Terminal structures of poliovirion RNA and poliovirus mRNA differ Excision of F plasmid sequences by recombination at directly repeated only in genome-linked protein VPg, 5345 insertion sequence 2 elements: Involvement of recA, 3965 Polyadenylate Plasmid F I Cytoplasmic nonpolysomal ribonucleoprotein particles in sea urchin Physical mapping of a DNA sequence common to plasmids of embryos and their relationship to protein synthesis, 2231 incompatibility group F I, 1190 HeLa cell poly(A)- mRNA codes for subset of poly(A)+ mRNA-directed Plasmid, mini-F proteins with actin as major product, 4801 Bidirection replication from a unique origin in a mini-F plasmid, 1138 RNA maturation: Leader sequences of simian virus 40 mRNA are not Plasmid, pBR322 transcribed adjacent to coding sequences, 3686 Expression in Escherichia coli K-12 of structural gene for catabolic Polyamine dehydroquinase of Neurospora crassa, 3508 Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic pBR345 plasmid DNA: Origin of replication, 5265 GMP from induction of ornithine decarboxylase by tumor promoter Plasmid P#G1 12-0-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo, 657 Structural gene identification and mapping by DNA.mRNA Dissociation of tumor promoter-stimulated ornithine decarboxylase hybrid-arrested cell-free translation, 4370 activity and DNA synthesis in mouse epidermis in vivo and in vitro by Plasmid, R fluocinolone acetonide, a tumor-promotion inhibitor, 3908 Selective amplification of genes on the R plasmid, NRI, in Proteus Poly(A) polymerase mirabilis: Example of induction of selective gene amplification, 2518 see Polynucleotide adenylyltransferase Plasmid, recombinant Polydeoxyribonucleotidesynthetase (ATP) (EC 6.5.1.1) Recombinant plasmid that carries part of nitrogen fixation (nif) gene Packaging recombinant DNA molecules into bacteriophage particles in cluster of Klebsiella pneumoniae, 2963 vitro, 3259 Plasmid, Ti Polyelectrolyte Thermosensitive step associated with transfer of Ti plasmid during Cryoenzymology in mixed solvents without cosolvent effects on enzyme conjugation: Relation to transformation in crown gall, 2848 specific activity, 2297 Plasmin Polyelectrolytetheory Macrophage migration inhibitory activity generated by plasminogen Ionic regulation in genetic translation systems, 1013 activators, 1570 Polylysine Proteolytic cleavage causes heterogeneity present in human Polylysine used for adsorption of nucleic acids and enzymes to electron ceruloplasmin preparations: Chemical evidence, 5377 microscope specimen films, 2311 Plasminogen Polymerization Fibrinolytic activator and inhibitor synthesized by endothelial cells, 3903 Stereochemistry of polymerization by DNA-dependent RNA-polymerase Macrophage migration inhibitory activity generated by plasminogen from Escherichia coli: Investigation with a diastereomeric activators, 1570 ATP-analogue (correction), 392 Plasmodium berghei Polymorphism Influence of 9-/-D-arabinofuranosyladenine on total protein synthesis Human plasma proteins: High resolution two-dimensional and on differential gene expression of unique proteins in the rodent electrophoresis, 5421 malarial parasite Plasmodium berghei, 3386 Mechanism of genetic coadaptation in populations of Drosophila Plasmodium formation melanogaster, 324 Extracellular inducer of asexual plasmodium formation in Physarum Polymorphism and subunit structure of enzymes: Neutralist-selectionist polycephalum, 1120 controversy, 698 Platelet Structural heterogeneity of C2 complement protein and its genetic Control of serotonin secretion from human platelets by hydroxyl ion variants in man: New polymorphism of HLA region, 1672 transport and osmotic lysis, 5295 Polynucleotide Cultured aortic endothelial cells from pigs with von Willebrand disease: Binding of mouse interferon to polynucleotides, 3787 In vitro model for studying molecular defect(s) of the disease, 5702 Netropsin-poly(dA-dT) complex in solution: Structure and dynamics of DNA synthesis induced in BALB/c 3T3 cells by serum components: antibiotic-free base pair regions and those centered on bound Reevaluation of commitment process, 4481 netropsin, 5207 Human platelet guanylate cyclase stimulated by unsaturated fatty acid Polynucleotidebinding site peroxides, 3657 Escherichia coli ribosomal protein S1 has two polynucleotide binding Imidazole: Selective inhibitor of thromboxane synthetase in human sites, 4786 platelets, 1716 Polynucleotide5'-hydroxyl-kinase (EC 2.7.1.78) Inhibition of human platelet thromboxane synthetase by Origin of replication of colicin El plasmid DNA, 1865 9,11-azoprosta-5,13-dienoic acid, 4007 Polynucleotidephosphorylase Interaction of coagulation factor Xa with human platelets, 4033 see Polyribonucleotide nucleotidyltransferase Ionophores stimulate prostaglandin and thromboxane biosynthesis, 4251 Polynucleotidestructure lonophores stimulate prostaglandin and thromboxane biosynthesis Spatial configuration of ordered polynucleotide chains: A novel double (correction), 5778 helix, 1775 Radioimmunoassay of human serum growth factor for Balb/c-3T3 cells: Polyomavirus Derivation from platelets, 1973 Analysis of polyoma virus nuclear RNA by mini-blot hybridization, 3138 Resolution of prostaglandin endoperoxide synthase and thromboxane 2'-Deoxy-2'-azidocytidine inhibits initiation of polyoma DNA synthesis, synthase of human platelets, 3691 5310 Synthesis of 13,14-dehydroprostacyclin methyl ester: Inhibitor of platelet Polyoma virus T antigen: Characterization, 1259 aggregation, 2199 Virus-specific proteins in plasma membrane of cells lytically infected or Two distinct adenosine-sensitive sites on adenylate cyclase, 5482 transformed by polyoma virus, 4666 Platelet aggregating factor Polypeptide Macromolecular Factor VIII complex: Functional and structural see also Receptor, polypeptide heterogeneity observed in von Willebrand swine with transfusion, 759 Hepatitis B surface antigen: Partial amino-acid sequence of two major Platelet aggregation component polypeptides, 1530 Prostaglandin 12 (prostacyclin) synthesized by cultured human and Polypeptide,hybrid bovine endothelial cells, 3922 Hybrid tryptophan synthetase a chain produced by genetic exchange Platelet factor 4 between Escherichia coli and Salmonella typhimurium, 286 Human platelet factor 4: Amino acid sequence, 2256 Polypeptideprecursor Platinum Cleavage of Rous sarcoma viral polypeptide precursor into internal Regulation of heme pathway enzymes and cellular glutathione content structural proteins in vitro involves viral protein pl5, 911 by metals that do not chelate with tetrapyrroles: Blockade of metal Polypeptide,vasoactive intestinal effects by thiols, 1875 Vasoactive intestinal polypeptide in brain: Localization in and release Pleurodeles waltlii from isolated nerve terminals, 3424 Gene activation in somatic nuclei after injection into amphibian oocytes, Polyploidy 2470 Polyploidy affects phosphoglucose isomerase diversity in Festuca Plodia interpunctella microstachys, 1652 Supercoiled circular DNA of insect granulosis virus, 3574 Polyribonucleotidenucleotidyltransferase (EC 2.7.7.8) Poecilia formosa Enzymatic synthesis of oligonucleotides of defined sequence: Synthesis Pyrimidine dimers in DNA can give rise to tumors, 5574 of segment of yeast iso-l-cytochrome c gene, 96 Poisson distribution Population Compound Poisson distribution: Prediction and estimation, 2670 Rapid speciation and chromosomal evolution in mammals, 3942 Downloaded by guest on September 27, 2021 Proc. 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Populationbiology Proalbumin Extension of longevity in Drosophila mojavensis by environnental Rat liver preproalbumin:In vitro synthesis and partialamino acid ethanol: Differences between subraces, 387 sequence, 1358 Generalizing Fisher's "reproductive value": Linear differential and Pro-C4 difference equations of "dilute" biological systems, 5189 Cell-freesynthesis of fourth componentof guinea pig complement(C4): Generalizing Fisher's "reproductive value": Nonlinear, homogeneous, Identificationof precursorof serumC4 (pro-C4),1707 biparental systems, 5772 Prochymosin Measures of fitness and demographic stability, 384 Prochymosin:Complete amino acid sequence,2321 Population genetics Procollagen Decay of genetic variability in geographically structured populations, Cell surface-associatedstructural proteins in connectivetissue cells, 2480 2523 Geneticsof connectivetissue proteins:Gene for humantype I Error estimate for diffusion approximation of Wright-Fisher model, 5096 procollagenassigned to chromosome17 by analysisof cell hybridsand How does selection reconcile individual advantage with the good of the microcellhybrids, 4444 group? 4542 Hexamethylenebisacetamide induces morphologic changes and increased Populationstructure synthesis of procollagenin cell line from glioblastomamultiforme, Theories of quasi-linkage and "affinity": Implications for population 5060 structure, 3513 Kinetics of processingof type I and type III procollagensin fibroblast Porphobilinogensynthase (EC 4.2.1.24) cultures,3322 5-Aminolevulinate dehydracase, uroporphyrinogen-I synthase, and Triple-helixformation on ribosome-boundnascent chains of procollagen: protoporphyrin IX: Levels in erythrocytes from anemic mtutant mice, Deuterium-hydrogenexchange studies, 902 1181 Productionsets Dissociation and reassociation of immobilized porphobilinogen synthase: Structureof productionsets with indivisibilities,3637 Use of immobilized subunits for enzyme isolation, 1383 Proflavine Enzymic defects in hereditary tyrosinemia, 4641 Sequencespecificity of mutagen-nucleicacid complexesin solution: Porphyria Intercalationand mutagen-basepair overlapgeometries for proflavine Postulated deficiency of hepatic heme and repair by hematin infusionls in bindingof dC-dC-dG-dGand dG-dG-dC-dCself-complementary "inducible" hepatic porphyrias, 2118 duplexes,2624 Porphyrin Progesterone Bonding of FeO2 in hemoglobin and related dioxygen complexes, 1780 Ionic requirementsfor inductionof maturation(meiosis) in full-grown Dioxygen bonding in hemoglobin: Molecular description, 1315 and medium-sizedXenopus laevis oocytes, 3461 Energy-structure correlation in metalloporphyrins and control of oxygen Ovarian"inhibin": Suppression of secondaryrise in serum follicle binding by hemoglobin, 1789 stimulatinghormone levels in proestrousrats by injectionof porcine Picosecond dynamics of iron proteins, 4139 follicularfluid, 5721 Synthesis and characterization of "face-to-face" porphyrins, 18 9S bindingprotein for androgensand progesterone,1960 Postsynapticdensity Prohormone Protein related to tubulin identified in the postsynaptic density, 1047 In vitro biosynthesisof /-endorphin, y-lipotropin,and /-lipotropin by Potassium pars intermediaof beef pituitaryglands, 4276 Calcium modulation in brain extracellular microenvironment Prokaryote demonstrated with ion-selective micropipette, 1287 Phylogeneticstructure of prokaryoticdomain: Primary kingdoms, 5088 Effect of increased potassium concentrations on particle motion within a Prolactin neurosecretory structure, 5759 Nascent prehormonesare intermediatesin biosynthesisof authentic Ionic requirements for induction of maturation (meiosis) in full-grown bovine pituitarygrowth hormone and prolactin,2432 and medium-sized Xenopus laevis oocytes, 3461 Proline Organic acid and potassium accumulation in guard cells during stomatal Collagendegradation in rat skin but not in intestine duringrapid opening, 4434 growth:Effect on collagentypes I and III from skin, 1436 Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by Proline oxidaseactivity regulatedby lactate, 5368 its effects on cell membrane (correction), 392 Unfoldingand refoldingoccur much faster for a proline-freeprotein than Random walk analysis of potassium fluxes associated with nerve for most proline-containingproteins, 4178 impulses, 5543 Proline oxidase (EC 1.5.1.2) 5'-Terminal 7-methylguanosine and mRNA function: Influence of Proline oxidase activity regulatedby lactate, 5368 potassium concentration on translation in vitro, 3254 Proline,2-oxoglutarate dioxygenase (EC 1.14.11.2) 5'-Terminal 7-methylguanosine and mRNA function: Influence of Homologybetween prolyl hydroxylasesubunit and tissue protein that potassium concentration on translation in vitro (correction), 5198 crossreactsimmunologically with the enzyme,4420 Vasoactive intestinal polypeptide in brain: Localization in and release Prolyl hydroxylase from isolated nerve terminals, 3424 see Proline, 2-oxoglutaratedioxygenase Potato spindle tuber viroid Promoter Separation and infectivity of circular and linear forms of potato spindle RNA polymerasebinding sites in Xplac5DNA, 4914 tuber viroid, 3859 Properdin Potential, early receptor Alternativecomplement pathway activated due to resistanceof Rhodopsin in model membranes: Charge displacements in interfacial zymosan-boundamplification convertase to endogenousregulatory layers, 207 mechanisms,1683 Poxvirus ProphageX Biogenesis of poxviruses: Analysis of morphogenetic sequence using a Initiationof genetic exchangesin Xphage-prophage crosses, 291 conditional lethal mutant defective in envelope self-assembly, 2162 Protease inhibitorblocks SOS functionsin Escherichiacoli: Antipain Precursormolecule prevents Xrepressor inactivation, ultraviolet mutagenesis, and Cell-free synthesis of fourth component of guinea pig complement (C4): filamentousgrowth, 1152 Identification of precursor of serum C4 (pro-C4), 1707 Protease inhibitorblocks SOS functionsin Escherichiacoli: Antipain Predator-preymodel prevents Xrepressor inactivation, ultraviolet mutagenesis, and Food webs and dimensionality of trophic niche space, 4533 filamentousgrowth (correction), 2594 Pregnancy ,-Propiolactone Human placental lactogen mRNA and its structural genes during In vitro evidenceof cell-mediatedimmunity after exposureof mice to pregnancy: Quantitation with complementary DNA, 1024 live and inactivatedrabies virus, 334 Pregnenolone Propranolol Detection in bovine adrenal cortex of a lipoidal substance that yields /-Adrenergicreceptors probed by fluorescent/-adrenergic blockers, 5290 pregnenolone upon treatment with alkali, 941 Prostacyclin Prekallikrein see Prostaglandin High-molecular-weight kininogen: Role in surface-binding and activation Prostaglandin of coagulation Factor XI and prekallikrein, 4636 Adenylatecyclase from synchronizedneuroblastoma cells: Prelumirhodopsin Responsivenessto prostaglandinEl, adenosine,and dopamineduring Primary photochemical event in vision: Proton translocation, 3119 cell cycle, 1575 Preproalbumin Adenylatecyclase permanentlyuncoupled from hormonereceptors in Rat liver preproalbumin: In vitro synthesis and partial amino acid novel variantof S49 mouse lymphomacells, 2016 sequence, 1358 Colchicineaffects cyclic AMP levels in humanleukocytes, 3404 Preproinsulin Collagensynthesis by chondrocytesin suspensionculture: Modulation by Cell-free synthesis of fish preproinsulin, and processing by heterologous calcium,3':5'-cyclic AMP, and prostaglandins,3864 mammalian microsomal membranes, 2059 Fibroblast heterogeneity and prostaglandin regulation of subpopulations, Presbytis obscurus 3429 Evolution of primate oncornaviruses: Endogenous virus from langurs Glucocorticoids increase responsiveness of cells in culture to (Presbytis spp.) with related virogene sequences in other Old World prostaglandin Em,4816 monkeys, 4557 Imidazole: Selective inhibitor of thromboxane synthetase in human Pressure platelets, 1716 Pressure affects visible spectra of complexes of myoglobin, hemoglobin, Inhibition of human platelet thromboxane synthetase by cytochrome c, and horse radish peroxidase, 1 9,11-azoprosta-5,13-dienoic acid, 4007 Principalseries representation Inhibition of prostaglandin endoperoxide synthetase by thiol analogues Classification of irreducible representations of semisimple Lie groups, of prostaglandin, 144 2649 Ionophores stimulate prostaglandin and thromboxane biosynthesis, 4251 Downloaded by guest on September 27, 2021 5840 SubjectIndex Proc. Natl. Acad. Sci. USA 74 (1977)

lonophores stimulate prostaglandin and thromboxane biosynthesis Protein cleavage (correction), 5778 DNA packaging and pathway of bacteriophage T4 head assembly, 3652 Novel prostaglandin is major product of arachidonic acid metabolism in Protein, cobalamin-binding rabbit heart, 101 Intracellular binding of radioactive hydroxocobalamin to Opiate-dependent modulation of adenylate cyclase, 3365 cobalamin-dependent apoenzymes in rat liver, 916 Prostaglandin 12 (prostacyclin) synthesized by cultured human and Recognition of two intracellular cobalamin binding proteins and their bovine endothelial cells, 3922 identification as methylmalonyl-CoA mutase and methionine Prostaglandin regulation of macrophage collagenase production, 4955 synthetase, 921 Synthesis of 13,14-dehydroprostacyclin methyl ester: Inhibitor of platelet Protein conformation aggregation, 2199 see also Conformation Temporal sequence of hormonal interactions during prereplicative phase Conversion of incomplete antibodies to direct agglutinins by mild of quiescent cultured 3T3 fibroblasts, 3845 reduction: Segmental flexibility within Fc fragment of Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin immunoglobulin G, 2531 methyl ester: Comparison with endoperoxides and other prostanoids, Homoserine dehydrogenase: Spontaneous reactivation by dissociation of 5711 p-mercuribenzoate from inactive enzyme-p-mercuribenzoate complex, Prostaglandin endoperoxide synthase 4862 Resolution of prostaglandin endoperoxide synthase and thromboxane Method for localizing proteins in periodic structures: Fab fragment synthase of human platelets, 3691 labeling combined with image processing of electron micrographs, 5514 Prostaglandin endoperoxide synthetase Rhodopsin in model membranes: Charge displacements in interfacial see Prostaglandin synthase layers, 207 Prostaglandin synthase (EC 1.14.99.1) Use of a distant reporter group as evidence for conformational change in Inhibition of prostaglandin endoperoxide synthetase by thiol analogues a sensory receptor, 1932 of prostaglandin, 144 Protein, contractile Protease Interaction of filamin with F-actin in solution, 2021 Antipain and leupeptin restrict uterine DNA synthesis and function in Protein, copper mice, 3754 Blue copper proteins: Synthesis, spectra, and structures of CuIN3(SR) Correlation of clotting protease activity in vitro and in vivo: Effect of and CuIIN3(SR) active site analogues, 3114 heparin, 3028 Protein, C-reactive Protease effects on specific growth properties of normal and transformed C-reactive protein and complement subcomponent Clt characterized as baby hamster kidney cells, 2874 homologous proteins diplaying cyclic pentameric symmetry Soluble ATP-dependent proteolytic system responsible for degradation (pentraxins), 739 of abnormal proteins in reticulocytes, 54 C-reactive protein and complement interact with liposomes, 5672 Protease deacylation Partial amino-acid sequences of human and rabbit C-reactive proteins: Intramolecular general base-catalyzed ester hydrolyses by imidazolyl Homology with immunoglobulins and histocompatibility antigens, group, 23 1214 Intramolecular general base-catalyzed ester hydrolyses by imidazolyl Primary structure of human C-reactive protein, 3148 group (correction), 3621 Protein crosslinking Protease inhibitor Release of ovoperoxidase from sea urchin eggs hardens fertilization Protease inhibitor blocks SOS functions in Escherichia coli: Antipain membrane with tyrosine crosslinks, 4214 prevents X repressor inactivation, ultraviolet mutagenesis, and Protein degradation filamentous growth, 1152 Cystinotic fibroblasts accumulate cystine from intracellular, 4505 Protease inhibitor blocks SOS functions in Escherichia coli: Antipain Protein, dnaB prevents X repressor inactivation, ultraviolet mutagenesis, and Migration of Escherichia coli dnaB protein on template DNA strand as filamentous growth (correction), 2594 mechanism in initiating DNA replication, 4190 Protein Protein, dnaG see also Actin-like protein; Allosteric protein; a-Fetoprotein; DNA or RNA priming of bacteriophage G4 DNA synthesis by Glycoprotein; Membrane protein; Metalloprotein; Phosphoprotein; Escherichia coli dnaG protein, 2815 Ribonucleoprotein; Transport, protein Protein dynamics Heat capacity and entropy changes in processes involving proteins, 2236 Flexibility of myosin rod, light meromyosin and myosin subfragment-2 in Immunofluorescent staining of cytoplasmic and spindle microtubules in solution, 4986 mouse fibroblasts with antibody to r protein, 2437 Tertiary structural change in hemoglobin: Mechanism, 801 Polypeptides of cells transformed by RNA or DNA tumor viruses, 2729 Protein, encephalitogenic Protein covalently linked to poliovirus genome RNA, 59 Unprimed spleen cell populations recognize macrophage-bound antigen Protein A24 with opposite net electric charge, 1693 Protein A24 in rat liver nucleosomes, 5492 Protein evolution Protein, abnormal Structure of cytochrome c555 of Chlorobium thiosulfatophilum: Primitive Soluble ATP-dependent proteolytic system responsible for degradation low-potential cytochrome c, 5244 of abnormal proteins in reticulocytes, 54 Protein, flagellar Protein, activator Flagellar proteins from wild-type and paralyzed mutants of Design of molecular control mechanisms and demand for gene Chlamydomonas reinhardtii: Two-dimensional analysis, 1600 expression, 5647 Protein folding Protein, amphiphilic Formation of four isomers of hen egg white lysozyme containing three Charge shift electrophoresis: Method for distinguishing between native disulfide bonds and one open disulfide bond, 2362 amphiphilic and hydrophilic proteins in detergent solution, 529 Modified form of /2 subunit of Escherichia coli tryptophan synthetase Protein assembly suitable for investigating protein folding, 442 Addition of colchicine-tubulin complex to microtubule ends: Mechanism Protein folding: Incorporation of a one-dimensional short-range (Ising) of substoichiometric colchicine poisoning, 3466 model into a three-dimensional model, 1320 Flagellar mutants of Chlamydomonas: Studies of radial spoke-defective Unfolding and refolding occur much faster for a proline-free protein than strains by dikaryon and revertant analysis, 3456 for most proline-containing proteins, 4178 Native human hemoglobin reconstituted from separated globin chains Protein, fractionI and alloplex intermediates, 64 Random assembly of different kinds of small subunit polypeptides Protein biosynthesis during formation of fraction I protein macromolecules, 3443 Isomeric aminoacyl-tRNAs are both bound by elongation factor Tu, 437 Protein, gene 4 Protein, brain Replication of duplex DNA by bacteriophage T7 DNA polymerase and Brain protein metabolism and acquisition of new patterns of behavior, gene 4 protein is accompanied by hydrolysis of nucleoside 1743 5'-triphosphates, 1525 Protein, calcium-binding Protein glycosylation Calcium-binding protein of chorioallantoic membrane: Identification and Changes in surface properties of normal and transformed cells caused by developmental expression, 1946 tunicamycin, inhibitor of protein glycosylation, 3433 Protein, cell surface Protein H6 see also Fibronectin Selective association of trout-specific H6 protein with chromatin regions Cell surface-associated structural proteins in connective tissue cells, 2480 susceptible to DNase I and DNase II: Location of HMG-T in spacer Cell surface carbohydrates and proteins in cell behavior: Biochemical region between core nucleosomes, 2810 reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 Protein, hepatic binding Cell-surface glycosyltransferases in cultured fibroblasts: Increased Lymphocyte mitogenesis induced by mammalian liver protein that activity and release during serum stimulation of growth, 1086 specifically binds desialylated glycoproteins, 676 Extensive disulfide bonding at mammalian cell surface, 2855 Protein, high molecularweight basic Levels of translatable mRNAs for cell surface protein, collagen Role of nucleotides in tubulin polymerization: Effect of guanylyl precursors, and two membrane proteins are altered in Rous sarcoma 5'-methylenediphosphonate, 4881 virus-transformed chick embryo fibroblasts, 3399 Protein HMG-T Mobility and distribution of a cell surface glycoprotein and its Selective association of trout-specific H6 protein with chromatin regions interaction with other membrane components, 2909 susceptible to DNase I and DNase II: Location of HMG-T in spacer Protein, chromosomal region between core nucleosomes, 2810 Isopeptide linkage between nonhistone and histone 2A polypeptides of Protein, hydrophilic chromosomal conjugate-protein A24, 864 Charge shift electrophoresis: Method for distinguishing between Protein, cistron A amphiphilic and hydrophilic proteins in detergent solution, 529 oX174 cistron A protein is a multifunctional enzyme in DNA replication, 3198 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5841

Protein, integration Protein phosphorylation Integration protein of bacteriophage X is a site-specific DNA-binding 3':5'-Cyclic-AMP-dependent protein kinase in regulation of protein protein, 1511 synthesis in reticulocyte lysates, 1463 Protein, ionophoro- Mechanism of phosphorylation of synthetic polypeptides by calf thymus ElectrogenicK+/Ca2+ ionophore isolated from an ionophoroproteinof cyclic AMP-dependent protein kinase, 4261 beef heart mitochondria, 3667 Phosphorylation of membrane proteins at cholinergic synapse, 263 Protein kinase Pineal proteinphosphorylation during serotonin N-acetyltransferase Activation of hormone-sensitive lipase and phosphorylase kinase by induction, 1928 purified cyclic GMP-dependent protein kinase, 4843 Protein, plasma Adenosine 3':5'-cyclic monophosphate- and guanosine 3':5'-cyclic Human plasma proteins: High resolution two-dimensional monophosphate-dependent protein kinases: Possible homologous electrophoresis, 5421 proteins, 3239 Protein polymerization 3':5'-Cyclic-AMP-dependent protein kinase in regulation of protein Disagreement between calorimetric and van't Hoff enthalpies of synthesis in reticulocyte lysates, 1463 assembly of protein supramolecular structures, 2002 In vivo and in vitro phosphorylation of rat liver Protein polymorphism fructose-1,6-bisphosphatase, 4615 Genetic variability maintained under mutation and selection pressures in Peptide initiation: Partial reaction inhibited by phosphorylation of a finite population, 2509 either initiation factor eIF-2 or 40S ribosomal proteins, 1445 Spontaneous mutation rates at enzyme loci in Drosophila melanogaster, Phosphorylation of membrane proteins at cholinergic synapse, 263 2514 Protein kinase (EC 2.7.1.37) Protein, precursor Intermediate role of adenosine 3':5'-cyclic monophosphate and protein Rat liver preproalbumin: In vitro synthesis and partial amino acid kinase during gonadotropin-induced steroidogenesis in testicular sequence, 1358 interstitial cells, 3419 Protein, presecretory Mechanism of phosphorylation of synthetic polypeptides by calf thymus Post-translational cleavage of presecretory proteins with extract of rough cyclic AMP-dependent protein kinase, 4261 microsomes from dog pancreas containing signal peptidase activity, Mechanism of translational control by hemin in reticulocyte lysates, 3326 5598 Pineal protein phosphorylation during serotonin N-acetyltransferase Protein regulation induction, 1928 Regulation of growth hormone gene expression: Synergistic effects of Subunit interaction in cyclic AMP-dependent protein kinase of mutant thyroid and glucocorticoid hormones, 4293 lymphoma cells, 1167 Protein, regulatory Translational control by protein kinases in Artemia salina and wheat Nonspecific DNA binding of genome-regulating proteins as biological germ, 4356 control mechanism: Measurement of DNA-bound Escherichia coli lac Protein, lac carrier repressor in vivo, 4228 Microenvironment of binding site in lac carrier protein, 1]851 Protein, rep Protein, LETS oX174 cistron A protein is a multifunctional enzyme in DNA replication, see Fibronectin 3198 Protein, liver Protein, ribosomal Lymphocyte mitogenesis induced by mammalian liver protein that Aminoacyl-tRNA binding at recognition site is first step of elongation specifically binds desialylated glycoproteins, 676 cycle of protein synthesis, 1903 Protein, malarial Conditionally lethal ribosomal protein mutants: Locus required for Influence of 9-/-D-arabinofuranosyladenine on total protein synthesis modification of 50S subunit proteins, 467 and on differential gene expression of unique proteins in the rodent Contrast variation study of specifically deuterated Escherichia coli malarial parasite Plasmodium berghei, 3386 ribosomal subunits, 5547 Protein, membrane Escherichia coli mutant with temperature sensitive function affecting see Membrane protein bacteriophage Q/1 RNA replication, 1657 Protein, methylated Escherichia coli 5S RNA binding proteins L18 and L25 interact with Chemotaxis in Escherichia coli: Methylation of che gene products, 3317 5.8S RNA but not with 5S RNA from yeast ribosomes, 2706 Sensory transduction in Escherichia coli: Two complementary pathways High-resolution proton magnetic resonance study of secondary structure of information processing that involve methylated proteins, 3312 of 3'-terminal 49-nucleotide fragment of 16S rRNA from Escherichia Protein methylation coli, 1028 Sensory transduction in Escherichia coli: Requirement for methionine in Interaction between mutations of ribosomes and RNA polymerase: A sensory adaptation, 183 pair of strA and rif mutants individually temperature-insensitive but Sensory transduction in Escherichia coli: Role of protein methylation temperature-sensitive in combination, 1157 reaction in sensory adaptation, 4964 mRNA-dependent in vitro synthesis of ribosomal proteins L12 and L10 Protein methyltransferase and elongationfactor Tu, 5387 Protein methyltransferase identified as cheR gene product in bacterial Mutant RNA polymerase in Escherichia coli: Regulation of synthesis sensing system, 533 and activity, 5416 Protein, microtubule-associated Nucleic acid helix-unwinding properties of ribosomal protein S1 and role In vitro assembly of pure tubulin into microtubules in absence of of S1 in mRNA binding to ribosomes, 2379 microtubule-associated proteins and glycerol, 1860 Peptide initiation:Partial reactioninhibited by phosphorylationof Protein, muscle either initiation factor eIF-2 or 40S ribosomal proteins, 1445 Major structural and regulatory proteins of chick muscle cells: Invariance Ribosomal mutations affect read-through of chain termination signal: and heterogeneity revealed by two-dimensional gel electrophoresis, Synthesis of bacteriophage X 0 gene protein in vitro, 689 1450 Protein Sl Protein, myeloma Escherichia coli ribosomal protein S1 has two polynucleotide binding Structure-function relations in phosphorylcholine-binding mouse sites, 4786 myeloma protein, 2109 Nucleic acid helix-unwinding properties of ribosomal protein S1 and role Protein, nonhistone of S1 in mRNA binding to ribosomes, 2379 Chromatinprotein appearsduring erythroid differentiation of Friend Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit virus-transformed cells, 653 synthesis of brain-specific protein in rat glial cells, 3855 Chromatin protein appears during erythroid differentiation of Friend ProteinSll virus-transformed cells (correction), 3104 Isopeptide linkage between N-a-monomethylalanine and lysine in Histone gene transcription activated by nonhistone chromosomal ribosomal protein Sll from Escherichia coli, 4905 proteins in WI-38 human diploid fibroblasts, 173 Protein SAA Isopeptide linkage between nonhistone and histone 2A polypeptides of Amyloid protein SAA is associated with high density lipoprotein from chromosomal conjugate-protein A24, 864 human serum, 4025 Protein A24 in rat liver nucleosomes, 5492 Protein secretion Protein scaffold isolated from mitotic HeLa cell chromosomes, 4937 Extracellular labeling of nascent polypeptides traversing the membrane Selective association of trout-specific H6 protein with chromatin regions of Escherichia coli, 2830 susceptible to DNase I and DNase II: Location of HMG-T in spacer Protein, secretory region between core nucleosomes, 2810 Amino-acid sequence of NH2-terminal extra piece segments of precursors Subunit structure of chromatin and organization of eukaryotic highly of mouse immunoglobulin Xl-type and K-type light chains, 716 repetitive DNA: Nucleosomal proteins associated with highly Enzymatic conversion of proteins to glycoproteins, 134 repetitive mammalian DNA, 3297 Protein, serum female Protein, nucleic acid helix-unwinding Sex-limited serum protein of Syrian hamsters: Definition of female Nucleic acid helix-unwinding properties of ribosomal protein S1 and role protein and regulation by testosterone, 730 of S1 in mRNA binding to ribosomes, 2379 Protein, soluble Protein, p30 Electron spin resonance absorption of tissue constituents, 1558 Antigenic crossreactivity to RD114 p30 protein, expressed in a human Protein, spore coat fibrosarcoma cell line, 744 Spore coat processing and protein turnover altered in a Bacillus cereus Protein P70 mutant with a defective postexponential intracellular protease, 1254 Murine leukemia virus morphogenesis: Cleavage of P70 in vitro can be Protein, steroid-binding accompanied by shift from concentrically coiled internal strand 9S binding protein for androgens and progesterone, 1960 ("immature") to collapsed ("mature") form of virus core, 3446 Protein, sterol-binding Protein, perithecial 25-Hydroxycholesterol and cholesterol bind to different cytoplasmic Major protein associated with fruiting body development in Neurospora proteins, 2500 and related ascomycetes, 3831 Downloaded by guest on September 27, 2021 5842 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Protein, structural Collagen synthesis by chondrocytes in suspension culture: Modulation by Cell surface-associated structural proteins in connective tissue cells, 2480 calcium, 3':5'-cyclic AMP, and prostaglandins, 3864 Electron spin resonance absorption of tissue constituents, 1558 Common precursor to corticotropin and /1-lipotropin: Cell-free synthesis Frog oocytes synthesize and completely process precursor polypeptide to of precursor and identification of corticotropin peptides in the virion structural proteins after microinjection of avian myeloblastosis molecule, 4826 virus RNA, 3230 Common precursor to corticotropin and /1-lipotropin: Identification of' Protein structure /-lipotropin peptides and their arrangement relative to corticotropin Conformation of f-endorphin and /-lipotropin: Formation of helical in precursor synthesized in cell-free system, 5300 structure in methanol and sodium dodecyl sulfate solutions, 3235 Differential utilization of leucyl tRNAs by Escherichia coli, 1393 C-reactive protein and complement subcomponent Clt characterized as Elongation factor Tu resistant to kirromycin in Escherichia coli mutant homologous proteins diplaying cyclic pentameric symmetry altered in both tuf genes, 4341 (pentraxins), 739 Escherichia coli alkaline phosphatase precursor: Synthesis and Hydrophobicity, hydrophilicity, and radial and orientational processing in vitro, 1440 distributions of residues in native proteins, 5248 Glucocorticoid effect on level of corticotropin messenger RNA activity in Identification of /,1-turns and unordered conformations in polypeptide rat pituitary, 3283 chains by vacuum ultraviolet circular dichroism, 3208 HeLa cell poly(A)- mRNA codes for subset of poly(A)+ mRNA-directed Lactate dehydrogenase isozymes: Structural adaptations, 2677 proteins with actin as major product, 4801 Local interactions in bends of proteins, 4126 Importance of 5'-terminal blocking structure to stabilize mRNA in Method for obtaining a high resolution protein map starting from a low eukaryotic protein synthesis, 2734 resolution map, 2835 Interaction of rabbit reticulocyte ribosomes with bacteriophage fl Oligosaccharides in human IgAl and IgA2 immunoglobulins: Location mRNA and of Escherichia coli ribosomes with rabbit globin mRNA, and structural significance, 2301 2692 Primary structure of human C-reactive protein, 3148 Interferon production and interferon messenger RNA synthesis in Protein structure of probable membrane derivation associated with human fibroblasts, 1483 HeLa cell mitochondrial DNA near its origin of replication, 1348 In vitro translation yields a possible Rous sarcoma virus src gene Proteolytic cleavage causes heterogeneity present in human product, 3302 ceruloplasmin preparations: Chemical evidence, 5377 Membrane assembly in vitro: Synthesis, glycosylation, and asymmetric Ribulose-1,5-bisphosphate carboxylase-oxygenase structure: Form III insertion of transmembrane protein, 3278 crystals, 1037 Molecular hybridization used to purify and analyze albumin messenger Structural convergence during protein evolution, 2820 RNA from rat liver, 4346 Structure of proteins: Packing of ac-helices and pleated sheets, 4130 mRNA-dependent in vitro synthesis of ribosomal proteins L12 and L10 Triple-helix formation on ribosome-bound nascent chains of procollagen: and elongation factor Tu, 5387 Deuterium-hydrogen exchange studies, 902 Nascent prehormones are intermediates in biosynthesis of authentic X-ray absorption studies of halide binding to carbonic anhydrase, 1794 bovine pituitary growth hormone and prolactin, 2432 Protein synthesis Polypeptide synthesis initiated with various NH2-blocked see also Peptide synthesis aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5509 Albumin synthesis in mouse uterus in response to liver mRNA, 1894 Proofreading of codon-anticodon interaction on ribosomes, 198 Aminoacyl-tRNA binding at recognition site is first step of elongation Rat liver factor that inhibits initiation of protein synthesis in rabbit cycle of protein synthesis, 1903 reticulocyte lysates, 2264 Cellular mRNA degraded during infection by herpes simplex virus, 2370 Structural gene identification and mapping by DNA.mRNA Changes in pattern of protein synthesis during meiotic maturation of hybrid-arrested cell-free translation, 4370 mammalian oocytes in vitro, 538 Tobacco necrosis virus and its satellite translated in a cell-free wheat Conformational alteration of protein synthesis elongation factor EF-Tu germ system, 2288 by EF-Ts and by kirromycin, 3264 Translation in vitro of rat liver messenger RNA coding f'or ligandin 3':5'-Cyclic-AMP-dependent protein kinase in regulation of protein (glutathione S-transferase B), 1899 synthesis in reticulocyte lysates, 1463 Translation of 35S and subgenomic regions of avian sarcoma virus RNA, Cytoplasmic nonpolysomal ribonucleoprotein particles in sea urchin 4661 embryos and their relationship to protein synthesis, 2231 Unwinding protein specific for mRNA translation fractionated together DNA-directed synthesis in vitro of /-galactosidase: Requirement for with rabbit reticulocyte initiation factor 3 complex, 2325 ribosome release factor, 3217 Protein, transmembrane Escherichia coli ribosomal protein S1 has two polynucleotide binding Membrane assembly in vitro: Synthesis, glycosylation, and asymmetric sites, 4786 insertion of transmembrane protein, 3278 Escherichia coli 5S RNA binding proteins L18 and L25 interact with Protein, transmembrane bridging 5.8S RNA but not with 5S RNA from yeast ribosomes, 2706 Transmembrane bridging proteins identified in plasma membrane of Expression of petite mitochondrial DNA in vivo: Zygotic gene rescue, cultured mouse L cells, 5341 2715 Protein turnover Extracellular labeling of nascent polypeptides traversing tlhe membrane Medium composition affects protein degradation and DNA synthesis in of Escherichia coli, 2830 rat embryo fibroblasts, 2427 Frog oocytes synthesize and completely process precursor polypeptide to Soluble ATP-dependent proteolytic system responsible for degradation virion structural proteins after microinjection of avian myeloblastosis of abnormal proteins in reticulocytes, 54 virus RNA, 3230 Protein unfolding Histone and DNA synthesis: Noncoincidence in cleavage cycles of early Enzymatic conversion of proteins to glycoproteins, 134 development, 5016 Protein, unwinding Identification of Rauscher murine leukemia virus-specific mRNAs for Unwinding protein specific for mRNA translation fractionated together synthesis of gag- aind env-gene products, 1855 with rabbit reticulocyte initiation factor 3 complex, 2325 Identification of recA (tif) gene product of Escherichia coli, 5280 Protein, viral Induction and decay of human fibroblast interferon mRNA, 4415 Cleavage of Rous sarcoma viral polypeptide precursor into internal Influence of 9-/-D-arabinofuranosyladenine on total protein synthesis structural proteins in vitro involves viral protein p15, 911 and on differential gene expression of unique proteins in the rodent DNA packaging and pathway of bacteriophage T4 head assembly, 3652 malarial parasite Plasmodium berghei, 3386 Interspecies radioimmunoassay for major structural proteins of primate Kinetic proofreading in aminoacylation of tRNA by synthetase, 2246 type-D retroviruses, 5739 Mechanism of translational control by hemin in reticulocyte lysates, 3326 Nucleotide sequence of 5' terminus of alfalfa mosaic virus RNA 4 leading Random assembly of different kinds of small subunit polypeptides into coat protein cistron, 5504 during formation of fraction I protein macromolecules, 3443 Protein VPg Role of ribothymidine in mammalian tRNAPhe, 3696 5'-Terminal structures of poliovirion RNA and poliovirus mRNA differ Synthesis of human interferon by Xenopus laevis oocytes: Two only in genome-linked protein VPg, 5345 structural genes for interferons in human cells, 3287 Protein X Translational control by protein kinases in Artemia salina and wheat Identification of recA (tif) gene product of Escherichia coli, 5280 germ, 4356 Protein X is product of recA gene of Escherichia coli, 5275 Translation of Drosophila melanogaster sequences in Escherichia coli, Proteoglycan 5041 Human platelet factor 4: Amino acid sequence, 2256 Protein synthesis, cell-free Proteoglycan, sulfated Amber and ochre mutants of human virus Ad2+ND1 identified, 4567 Cellular transformation and differentiation: Effect of Rous sarcoma virus Amino acid sequence of precursor region of MOPC-315 mouse transformation on sulfated proteoglycan synthesis by chicken immunoglobulin heavy chain, 5692 chondrocytes, 4173 Cell-cell interactions in conjugating Escherichia coli: Role of traT Proteolysis protein in surface exclusion, 5104 Soluble ATP-dependent proteolytic system responsible for degradation Cell-free synthesis of fish preproinsulin, and processing by heterologous of abnormal proteins in reticulocytes, 54 mammalian microsomal membranes, 2059 Proteus mirabilis Cell-free synthesis of fourth component of guinea pig complement (C4): Selective amplification of genes on the R plasmid, NR1, in Proteus Identification of precursor of serum C4 (pro-C4), 1707 mirabills: Example of induction of selective gene amplification, 2518 Cell-free synthesis of precursor polypeptide for avian myeloblastosis Prothrombin virus DNA polymerase, 4951 Amino acid sequence of human prothrombin fragments I and 2, 1969 Cell-free synthesis of two proteins unique to RNA of transforming Proton channeling virions of Rous sarcoma virus, 2011 Isolation of chloroplast N,N'-dicyclohexylcarbodiimide-binding Cell-free translation of simian virus 40 early messenger RNA coding for proteolipid, active in proton translocation, 2375 viral T-antigen, 457 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5843

Proton, hydrogen-bonded Quantumefficiency Hydrogen-bondedproton in tertiarystructure of yeast tRNAPhein Quantum efficiency of photosynthetic energy conversion, 3377 solution, 1561 Quantummechanics Proton magneticresonance Relaxation phenomena: A general treatment, 3623 see also Nuclearmagnetic resonance Quantum statistics High-resolutionproton magnetic resonance study of secondarystructure Quantum statistical theory of optical phenomena, 3105 of 3'-terminal49-nucleotide fragment of 16S rRNA from Escherichia Quantumyield coli, 1028 Quantum yields for oxygenic and anoxygenic photosynthesis in Selective recognitionof nucleic acids by proteins:Specificity of guanine cyanobacterium Oscillatoria limnetica, 2152 interactionwith carboxylateions, 4872 Quasar Protonmotiveforce Galaxies: Outstanding problems and instrumental prospects for the Protonmotiveforce drives bacterialflagella, 3060 coming decade (Review), 1767 Sodium-stimulatedglutamate uptake in membranevesicles of Quinacrine Escherichiacoli: Role of ion gradients,3167 Amino-acid transport into Ehrlich cells: Unexpected additional mode of Protonophore energization, 1488 Uncouplersand molecularmechanism of uncouplingin mitochondria, Quinatedehydrogenase (EC 1.1.1.24) 2241 De novo synthesis of qa enzymes of Neurospora crassa during induction, Proton pump 4256 Orientationof bacteriorhodopsinin Halobacteriumhalobium studied by Quinicacid selective proteolysis,5426 De novo synthesis of qa enzymes of Neurospora crassa during induction, Proton translocation 4256 Primaryphotochemical event in vision:Proton translocation,3119 3-Quinuclidinylbenzilate ProtoporphyrinIX Muscarinic acetylcholine receptors in developing retina, 5524 6-Aminolevulinatedehydratase, uroporphyrinogen-I synthase, and protoporphyrinIX: Levels in erythrocytesfrom anemic mutant mice, 1181 Rabies virus Provirus In vitro evidence of cell-mediated immunity after exposure of mice to Cleavagemap of linearmouse sarcomavirus DNA, 29 live and inactivated rabies virus, 334 Integrationof avian sarcomavirus DNA sequencesin transformed Radiationdamage mammaliancells, 4301 13C nuclear magnetic resonance studies of radiation damage: Pseudomonasmaltophilia Radiation-induced degradation of glycine, 2394 Specific gonadotropinbinding to Pseudomonasmaltophilia, 878 Radiationlesstransition Psoralen,4,5',8-trimethyl- Radiationless relaxation in "large" molecules: Preparation of true Initiationof genetic exchangesin X phage-prophagecrosses, 291 molecular eigenstates and Born-Oppenheimer states by a coherent Psychology light source, 1310 Behavior-geneticanalysis of Phormiaregina: Conditioning, reliable Radiation,synchrotron individualdifferences, and selection, 5193 X-ray absorption edge studies on oxidized and reduced cytochrome c Effects of naloxoneon experimentallyinduced ischemic pain and on oxidase, 3821 mood in humansubjects, 1291 Radioimmunoassay Heavy water as a tool for study of forcesthat controllength of period of Cholecystokinin and its COOH-terminal octapeptide in pig brain, 3035 the 24-hourclock of hamsters,1295 Human somatotropin: Restoration of full biological activity by Psychosis noncovalent interaction of natural and synthetic fragment of the Opposingeffects of dopaminergicto cholinergiccompounds on cerebral hormone, 1016 dopamine-activatedadenylate cyclase, 769 Interspecies radioimmunoassay for major structural proteins of primate Pterin-6-aldehyde type-D retroviruses, 5739 Pterin-6-aldehyde,a cancercell catabolite:Identification and application Multiple antigenic determinants on major surface glycoprotein of murine in diagnosisand treatmentof humancancer, 587 mammary tumor viruses, 3564 Puberty Prelarge and presmall basic proteins in mouse myelin and their Carcasscomponents at first estrus of rats on high-fat and low-fat diets: structural relationship to large and small basic proteins, 3360 Body water,protein, and fat, 379 Radioimmunoassay of human serum growth factor for Balb/c-3T3 cells: Pupariationfactor Derivation from platelets, 1973 Role of ecdysone,pupariation factors, and cyclic AMP in formationand Radiotherapy tanning of pupariumof fleshfly Sarcophagabullata, 4697 Solid tumor models for assessment of different treatment modalities: Puparium Therapeutic strategy for sequential chemotherapy with radiotherapy, 3':5'-CyclicAMP and hormonalcontrol of pupariumformation in fleshfly 1983 Sarcophagabullata, 2182 Ramanspectroscopy Purine-nucleosidephosphorylase (EC 2.4.2.1) Excited state lifetimes in cytochromes measured from Raman scattering Lymphospecifictoxicity in adenosinedeaminase deficiency and purine data: Iron-porphyrin interactions, 2607 nucleosidephosphorylase deficiency: Role of nucleosidekinase(s), 5677 Nucleic acid components: Ultraviolet resonant Raman spectroscopy, 2639 Purple sulfur photosyntheticbacterium Resonance coherent anti-Stokes Raman scattering spectra of fluorescent see Chromatiumvinosum biological chromophores: Vibrational evidence for hydrogen bonding of Pyridine derivative flavin to glucose oxidase and for rapid solvent exchange, 4146 Controlof growthby picolinicacid: Differential response of normaland Time-resolved resonance Raman spectroscopy of bacteriorhodopsin on transformedcells, 2889 the millisecond timescale, 5212 Pyridoxal5'-phosphate Rana catesbeiana 31p nuclearmagnetic resonance studies of glycogenphosphorylase from Sensitivity, polarity, and conductance change in response of vertebrate rabbit skeletal muscle:Ionization states of pyridoxal5'-phosphate, 856 hair cells to controlled mechanical stimuli, 2407 Pyridoxalphosphate: Location in glycogenphosphorylase a, 4757 Rana pipiens Pyrimidinedimer Selective reinnervation in skin-grafted Rana pipiens: Neurophysiological Differencesin removalof acetylaminofluoreneand pyrimidinedimers and behavioral evidence, 5749 from DNA of culturedmammalian cells, 1553 Randomdrift Pyrimidinedimers in DNA can give rise to tumors,5574 Decay of genetic variability in geographically structured populations, Pyrimidine5'-nucleotidase 2523 Humanerythrocyte pyrimidine 5'-nucleotidase: Purification and Randomwalk properties,3701 Random walks and generalized master equations with internal degrees of Pyrogen,leukocytic freedom, 430 Humanleukocytic pyrogen: Purification and development,of Rat radioimmunoassay,4624 Carcass components at first estrus of rats on high-fat and low-fat diets: Pyroglutamateaminopeptidase (EC 3.4.11.8) Body water, protein, and fat, 379 Thyrotropin-releasinghormone-like material in rat retina:Changes due Neurophysin biosynthesis in normal rats and in rats with hereditary to environmentallighting, 3579 diabetes insipidus, 4046 Pyrophosphatase Sequence relationship between long and short repetitive DNA of the rat, Importanceof 5'-terminalblocking structure to stabilize mRNA in 4382 eukaryoticprotein synthesis, 2734 Receptor,acetylcholine Pyrophosphate Accelerated degradation of acetylcholine receptor from cultured rat Complexes of inorganic pyrophosphate, orthophosphate, and calcium as myotubes with myasthenia gravis sera and globulins, 2130 stimulants of 3T3 cell multiplication, 5026 Affinity alkylation labels two subunits of reduced acetylcholine receptor N-Acetylglucosamine incorporated into endogenous acceptors of rough from mammalian muscle, 4685 microsomes from rat liver: Stimulation by GTP after treatment with Development of electrophysiological and biochemical membrane pyrophosphate, 1095 properties during differentiation of embryonic skeletal muscle in Pyruvatedehydrogenase (EC 1.2.4.1) culture, 5166 Acyl group and electron pair relay system: Network of interacting lipoyl Distinctions between two-state and sequential models for cooperative moieties in pyruvate and o-ketoglutarate dehydrogenase complexes ligand binding, 139 from Escherichia coli, 4223 Dynamic properties of isolated acetylcholine receptor proteins: Release Pyruvate kinase (EC 2.7.1.40) of calcium ions caused by acetylcholine binding (correction), 1763 Monomeric form of pyruvate kinase in human pyruvate kinase Functional acetylcholine receptor-electroplax membrane microsacs deficiency, 501 (vesicles): Purification and characterization, 482 Downloaded by guest on September 27, 2021 5844 SubjectIndex Proc. Natl. Acad. Sci. USA 74 (1977)

Histrionicotoxin enhances agonist-induced desensitization of Receptor,lymphocyte acetylcholine receptor, 5754 Immunoglobulin-dependent antigen-specific helper T cell, 4582 Human myasthenia gravis: Electrophysiological and ultrastructural Receptor,membrane evidence compatible with antibody attachment to acetylcholine Nerve growth factor receptors on human melanoma cells in culture, 565 receptor complex (correction), 1301 125I-labeled phytochrome used to quantitate phytochrome binding to Immunological distinction between acetylcholine receptor and membranes of Avena sativa, 4439 a-bungarotoxin-binding component on sympathetic neurons, 4689 Receptor,mitogen Modulation of acetylcholine receptor by antibody against receptor, 3090 Density-dependent regulation of growth of BSC-1 cells in cell culture: Muscarinic acetylcholine receptors in developing retina, 5524 Control of growth by serum factors, 5046 Neurotoxin a from venom of Philippines sea snake: Three-dimensional Receptor,morphine structure, 971 Opiate-dependent modulation of adenylate cyclase, 3365 Perhydrohistrionicotoxin: Potential ligand for ion conductance Receptor,nerve growthfactor modulator of acetylcholine receptor, 2172 Nerve growth factor receptors: Identification of distinct classes in plasma Phosphorylation of membrane proteins at cholinergic synapse, 263 membranes and nuclei of embryonic dorsal root neurons, 2785 Physical-chemical approach to transient change in Na ion conductivity Receptor,opiate of excitable membranes (correction), 3621 Biologically active conformation of opiates and enkephalin, 5179 Stimulus-secretion coupling in chromaffin cells isolated from bovine Endogenous nonpeptide morphine-like compound: Binding to opiate adrenal medulla, 5036 receptors, 4927 Synaptic acetylcholine receptor sites identified in retina with Opiate receptor: Cooperativity of binding observed in brain slices, 5764 peroxidase-labeled (a-bungarotoxin, 3268 Opioid peptide enkephalin: Immunohistochemical mapping in rat central Receptor, /1-adrenergic nervous system, 2167 Adenylate cyclase-free, /-adrenergic receptor isolated from turkey Receptor,polypeptide erythrocyte membranes by affinity chromatography, 3710 Specific receptor sites for chemotactic peptides on human Adenylate cyclase permanently uncoupled from hormone receptors in polymorphonuclear leukocytes, 1204 novel variant of S49 mouse lymphoma cells, 2016 Receptor,steroid /-Adrenergic receptors probed by fluorescent /-adrenergic blockers, 5290 Glucocorticoid-stimulated accumulation of mouse mammary tumor virus Calcitonin: Its hormonal action on gill, 4693 RNA: Increased rate of synthesis of viral RNA, 2879 Catecholamine binding to /-adrenergic receptor, 515 Recessivedystrophic epidermolysis bullosa Conformational requirements for dopamine-induced vasodilation, 3602 Recessive dystrophic epidermolysis bullosa: Evidence for altered Induction of functional /-adrenergic receptors in HeLa cells, 873 collagenase in fibroblast cultures, 4646 Reconstitution of catecholamine-sensitive adenylate cyclase activity: Recombination Interaction of solubilized components with receptor-replete see also Deoxyribonucleic acid, recombinant membranes, 3715 Recombination,genetic Receptor, antibody DNA-dependent RNA polymerase involved in a recA-independent Accelerated degradation of acetylcholine receptor from cultured rat pathway of genetic recombination in Escherichia coli, 3932 myotubes with myasthenia gravis sera and globulins, 2130 Hybrid tryptophan synthetase a chain produced by genetic exchange Receptor, cell surface between Escherichia coli and Salmonella typhimurium, 286 Antitubulins affect redistribution of crosslinked receptors on surface of Inhibitors of genetic recombination in pneumococci, 296 fibroblasts and epithelial cells, 2865 Initiation of genetic exchanges in X phage-prophage crosses, 291 Molecular weight and valence of cell-surface receptor for Integration protein of bacteriophage h is a site-specific DNA-binding immunoglobulin E, 869 protein, 1511 Multispecific lymphoid cell surface receptors, 1224 Mechanism of genetic recombination: Maturation of recombination Receptor diffusion on cell surfaces modulated by locally bound intermediates, 4168 concanavalin A, 1110 Renaturation of complementary single-stranded DNA circles: Complete Transmembrane interactions and mechanism of capping of surface rewinding facilitated by DNA untwisting enzyme, 5328 receptors by their specific ligands, 5031 Theories of quasi-linkage and "affinity": Implications for population Receptor, concanavalin A structure, 3513 Glycophorin and the concanavalin A receptor of human erythrocytes: Recombination, intragenic Receptor function in lipid bilayers, 2751 Genetic evidence for inducibility of recombination competence in yeast, Ligand-independent cap formation: Redistribution of surface receptors 1667 on mouse lymphocytes and thymocytes in hypertonic medium, 4511 Recombination,mitotic Receptor, dopamine Simple Mendelian inheritance of reiterated ribosomal DNA of yeast, Brain dopamine receptors: Detection with [3H]dihydroergocryptine, 3750 5091 Receptor, enzyme Redox potential Transition state structures of dipeptide related to mode of action of Bonding of FeO2 in hemoglobin and related dioxygen complexes, 1780 /-lactam antibiotics, 5239 Reflex Receptor, epidermal growth factor Centers involved in autonomic reflex reactions originating from Local starvation for epidermal growth factor cannot explain stretching of the atria, 2177 density-dependent inhibition of normal human glial cells, 1619 Reflex, gill withdrawal Specific radiolabeling of cell surface receptor for epidermal growth Facilitation at neuromuscular junctions: Contribution to habituation and factor, 2790 dishabituation of Aplysia gill withdrawal reflex, 1267 Receptor, estradiol Reflex, proboscis Estradiol receptor of calf uterus: Interaction with heparin-agarose and Behavior-genetic analysis of Phormia regina: Conditioning, reliable purification, 4886 individual differences, and selection, 5193 a-Fetoprotein is not a component of estradiol receptor of rat uterus, Regeneration 2269 Bioelectricity and regeneration: Large currents leave stumps of Receptor, estrogen regenerating newt limbs, 4528 Antibodies to estrogen receptor: Immunochemical similarity of Regressionmodel estrophilin from various mammalian species, 3681 Strong consistency of least-squares estimates in regression models, 2667 Receptor, Fc Reidemeistertorsion Dimeric immunoglobulin E serves as unit signal for mast cell Analytic torsion and Reidemeister torsion, 2651 degranulation, 2993 Relaxationphenomenon Receptor, galactose Relaxation phenomena: a general treatment, 3623 Use of a distant reporter group as evidence for conformational change in Renal medulla a sensory receptor, 1932 Ionophores stimulate prostaglandin and thromboxane biosynthesis, 4251 Receptor, glucocorticoid lonophores stimulate prostaglandin and thromboxane biosynthesis Dephosphorylation inactivates glucocorticoid receptors, 1398 (correction), 5778 Receptor, hormone Renilla reniformis Adenylate cyclase permanently uncoupled from hormone receptors in Structure of native Renilla reniformis luciferin, 4285 novel variant of S49 mouse lymphoma cells, 2016 Renin Catecholamine hormone receptor differences identified on 3T3 and Genetic control of renin activity in submaxillary gland of the mouse, simian virus-transformed 3T3 cells, 1091 1185 Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of Reovirus GTP hydrolysis at regulatory site, 3307 Molecular basis of reovirus virulence: Role of S1 gene, 5744 Relative conformational rigidity in oxytocin and Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins [1-penicillamine]oxytocin: Relationship of conformational flexibility to in initiation complexes, 4288 peptide hormone agonism and antagonism, 1373 Replicationorigin Topographic separation of adenylate cyclase and hormone receptors in Cloning and mapping of replication origin of Escherichia coli, 5458 plasma membrane of toad erythrocyte ghosts, 2860 Repressor Receptor, immunoglobulin Design of molecular control mechanisms and demand for gene Differential lateral mobility of IgM and IgG receptors in mouse B expression, 5647 lymphocyte membranes, 4595 Repressor,bacteriophage X Receptor,insulin Inactivation and proteolytic cleavage of phage h repressor in vitro in an Alterations in insulin binding accompanying differentiation of 3T3-L1 ATP-dependent reaction, 2283 preadipocytes, 4876 Repressor,hemin-controlled Biotinylinsulins as potential tools for receptor studies, 2697 Peptide initiation: Partial reaction inhibited by phosphorylation of Cellular uptake and nuclear binding of insulin in human cultured either initiation factor eIF-2 or 40S ribosomal proteins, 1445 lymphocytes: Potential intracellular sites of insulin action, 1368 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5845

Repressor, lac Retinal rod outer segment Binding of synthetic lactose operator DNAs to lactose repressors, 3292 Light-regulated permeability of rhodopsin:egg phosphatidylcholine Contacts between lac repressor and thymines in lac operator, 4973 recombinant membranes, 5222 Minimal length of lactose operator sequence for specific recognition by Proton spin-lattice relaxation of retinal rod outer segment membranes lactose repressor, 966 and liposomes of extracted phospholipids, 1978 Nonspecific DNA binding of genome-regulating proteins as biological Retinoic acid control mechanism: Measurement of DNA-bound Escherichia coli lac Retinoic acid (vitamin A acid) induced transcriptional control of repressor, in vivo, 4228 interferon production, 5382 5'-Terminal nucleotide sequence of Escherichia coli lactose repressor Retinol mRNA: Features of translational initiation and reinitiation sites, 4163 Membrane fusion: Studies with a calcium-sensitive dye, arsenazo III, in Reserpine liposomes, 1580 Collagen biosynthesis in blood vessels and other tissues reduced by Transfer of mannose from mannosyl retinyl phosphate to protein, 3762 reserpine and hypophysectomy, 777 Retinotopy Resonance Raman spectroscopy How to label nerve cells so that they can interconnect in an ordered Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: Nature fashion, 5176 of the azotyrosyl-248.zinc complex, 3273 Retrovirus Respiratory control Endogenous new world primate retrovirus: Interspecies antigenic Coupling in cytochrome c oxidase, 3662 determinants shared with major structural protein of type-D RNA Restriction endonuclease viruses of old world monkeys, 5734 see also Endonuclease Interspecies radioimmunoassay for major structural proteins of primate Bidirection replication from a unique origin in a mini-F plasmid, 1138 type-D retroviruses, 5739 Cleavage map of linear mouse sarcoma virus DNA, 29 Reverse transcriptase Cleavage specificity of restriction endonuclease isolated from see Deoxyribonucleic acid nucleotidyltransferase, ribonucleic Haemophilus gallinarum (Hga I), 3213 acid-dependent Cloned segment of Drosophila melanogaster rDNA containing new types Review of sequence insertion, 4932 Galaxies: Outstanding problems and instrumental prospects for the Cloning and mapping of replication origin of Escherichia coli, 5458 coming decade (Review), 1767 Cloning specific segments of mammalian genome: Bacteriophage X Structure determination of gaseous and amorphous substances by containing mouse globin and surrounding gene sequences, 4406 diffraction methods: Philosophical concepts and their implementation 2'-Deoxy-2'-azidocytidine inhibits initiation of polyoma I)NA synthesis, (Review), 4707 5310 Weather modification technology: Statistician's view (Review), 4714 DNA fragment containing origin of replication of Escherichia coli Rhizobium meliloti chromosome, 2720 Genetic mapping of Rhizobium meliloti, 2076 Epstein-Barr viral DNAs compared in Burkitt lymphoma biopsy cells Rhizopus chinensis and in cells clonally transformed in vitro, 4651 Homology among acid proteases: Comparison of crystal structures at 3A Filamentous coliphage M13 as cloning vehicle: Insertion of HindII resolution of acid proteases from Rhizopus chinensis and Endothia fragment of lac regulatory region in M13 replicative form in vitro, parasitica, 556 3642 Rhodium Helper factor(s) for growth of adeno-associated virus in cells transformed Structure of transition-metal cluster compounds: Use of additional by adenovirus 12, 4508 orbital resulting from f, g character of spd bond orbitals, 5235 Infectious DNA of spleen necrosis virus is integrated at a single site in Rhodopseudomonas sphaeroides DNA of chronically infected chicken fibroblasts, 281 Light collection and harvesting processes in bacterial photosynthesis Integration of avian sarcoma virus DNA sequences in transformed investigated on picosecond time scale, 1997 mammalian cells, 4301 Rhodopsin Isolation and characterization of XpolA transducing phage, 5632 see also Bacteriorhodopsin; Prelumirhodopsin Maize chloroplast DNA fragment encoding large subunit of Light-activated GTPase in vertebrate photoreceptors: Regulation of ribulosebisphosphate carboxylase, 5487 light-activated cyclic GMP phosphodiesterase, 4238 Mapping of closed circular DNAs by cleavage with restriction Light-regulated permeability of rhodopsin:egg phosphatidylcholine endonucleases and calibration by agarose gel electrophoresis, 851 recombinant membranes, 5222 Mapping of transcription sites of simian virus 40-specific late 16S and Primary photochemical event in vision: Proton translocation, 3119 19S mRNA by electron microscopy, 496 Rhodopsin in model membranes: Charge displacements in interfacial Nucleotide sequences of untranslated 5' regions of human a- and layers, 207 /-globin mRNAs, 5145 Rho factor pBR345 plasmid DNA: Origin of replication, 5265 Conditional-lethal rho mutants of Escherichia coli: Isolation and RNA polymerase binding sites in Xplac5 DNA, 4914 characterization, 1162 Simple Mendelian inheritance of reiterated ribosomal DNA of yeast, Ribonuclease I (EC 3.1.4.22) 5091 Ionic regulation in genetic translation systems, 1013 Site-specific genetic recombination promoted in vivo by EcoRI Multispecific lymphoid cell surface receptors, 1224 restriction endonuclease, 4811 Ribonuclease III Structure of promoter for T7 RNA polymerase, 4266 see Endoribonuclease III Subunit structure of chromatin and organization of eukaryotic highly Ribonucleic acid repetitive DNA: Nucleosomal proteins associated with highly see also Nucleic acid repetitive mammalian DNA, 3297 Detection of specific RNAs in agarose gels by transfer to Thermostable sequence-specific endonuclease from Thermuts aquaticus, diazobenzyloxymethyl-paper and hybridization with DNA probes, 5350 542 Ribonucleic acid, heterogeneous nuclear Restriction enzyme Evidence from UV transcription mapping in HeLa cells that Mapping of sequences with 2-fold symmetry on simian virus 40 genome: heterogeneous nuclear RNA is the messenger RNA precursor, 4520 Photochemical crosslinking approach, 1363 Heterogeneous nuclear RNA secondary structure: Oligo(U) sequences Recombinant plasmid that carries part of nitrogen fixation (nif) gene base-paired with poly(A) and their possible role as binding sites for cluster of Klebsiella pneumoniae, 2963 heterogeneous nuclear RNA-specific proteins, 1426 Reticulocyte Nucleoplasmic RNA: Definition of subclasses, 5011 Mechanism of translational control by hemin in reticulocyte lysates, 3326 Oligouridylate stretches in heterogeneous nuclear RNA, 2217 Rat liver factor that inhibits initiation of protein synthesis in rabbit Putative precursor of globin messenger RNA purified from mouse reticulocyte lysates, 2264 nucleated erythroid cells, 178 Soluble ATP-dependent proteolytic system responsible for degradation Secondary structure of heterogeneous nuclear RNA: Two classes of of abnormal proteins in reticulocytes, 54 double-stranded RNA in native ribonucleoprotein, 3705 Reticulocyte lysate Ribonucleic acid ligase 3':5'-Cyclic-AMP-dependent protein kinase in regulation of protein Bacteriophage T4 RNA ligase is gene 63 product, the protein that synthesis in reticulocyte lysates, 1463 promotes tail fiber attachment to baseplate, 3355 Reticulocytosis Dinucleoside pyrophosphates are substrates for T4-induced RNA ligase, 6-Aminolevulinate dehydratase, uroporphyrinogen-I synthase, and 4839 protoporphyrin IX: Levels in erythrocytes from anemic mutant mice, Ribonucleic acid, messenger 1181 Cytoplasmic nonpolysomal ribonucleoprotein particles in sea urchin Retina embryos and their relationship to protein synthesis, 2231 Gyrate atrophy of choroid and retina: Deficiency of ornithine Interaction of rabbit reticulocyte ribosomes with bacteriophage fl aminotransferase in transformed lymphocytes, 5159 mRNA and of Escherichia coli ribosomes with rabbit globin mRNA, Light-activated GTPase in vertebrate photoreceptors: Regulation of 2692 light-activated cyclic GMP phosphodiesterase, 4238 Nucleic acid helix-unwinding properties of ribosomal protein S1 and role Muscarinic acetylcholine receptors in developing retina, 5524 of S1 in mRNA binding to ribosomes, 2379 Synaptic acetylcholine receptor sites identified in retina with Rat liver preproalbumin: In vitro synthesis and partial amino acid peroxidase-labeled o-bungarotoxin, 3268 sequence, 1358 Thyrotropin-releasing hormone-like material in rat retina: Changes due 5'-Terminal capping of RNA by guanylyltransferase from HeLa cell to environmental lighting, 3579 nuclei, 3758 Retinal Translation of melittin messenger RNA in vitro yields a product Electronically excited retinal, 3375 terminating with glutaminylglycine rather than with glutaminamide, Orientation of bacteriorhodopsin in Halobacterium halobium studied by 975 selective proteolysis, 5426 Unwinding protein specific for mRNA translation fractionated together with rabbit reticulocyte initiation factor 3 complex, 2325 Downloaded by guest on September 27, 2021 5846 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Ribonucleic acid, messenger, albumin Loop structures in hybrids of early RNA and separated strands of Distribution of rat liver albumin RNA in membrane-bound and free adenovirus DNA, 4392 polyribosomes as determined by molecular hybridization, 5397 Ribonucleic acid, messenger, viral Molecular hybridization used to purify and analyze albumin messenger Cell-free translation of simian virus 40 early messenger RNA coding for RNA from rat liver, 4346 viral T-antigen, 457 Ribonucleic acid, messenger, araBAD Envelope-glycoprotein messenger activities of avian leukosis viral RNAs: Nucleotide sequence of 5' end of araBAD operon messenger RNA in Microinjection analysis, 1614 Escherichia coli B/r, 49 In vitro synthesis of messenger RNA by a defective interfering particle Ribonucleic acid, messenger, bacterial of vesicular stomatitis virus, 1884 Amino acid sequence for peptide extension on prolipoprotein of Mapping of transcription sites of simian virus 40-specific late 16S and Escherichia coli outer membrane, 1004 19S mRNA by electron microscopy, 496 Ribonucleic acid, messenger, corticotropin Nucleotide sequence from a ribonuclease III processing site in Glucocorticoid effect on level of corticotropin messenger RNA activity in bacteriophage T7 RNA, 822 rat pituitary, 3283 Nucleotide sequence of 5' terminus of alfalfa mosaic virus RNA 4 leading Ribonucleic acid, messenger, a-crystallin into coat protein cistron, 5504 Lens (Y-crystallin 14S mRNA: Bicistronic nature, 5448 Nucleotide sequences of ribosome recognition sites in messenger RNAs Ribonucleic acid, messenger, globin of vesicular stomatitis virus, 3672 Authentic /-globin mRNA sequences in homozygous /?-thalassemia, Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins 3047 in initiation complexes, 4288 Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: RNA maturation: Leader sequences of simian virus 40 mRNA are not Increased transcription during erythroid differentiation, 2475 transcribed adjacent to coding sequences, 3686 Inhibition of transcription and translation of globin messenger RNA in Sequence arrangement of 5' ends of simian virus 40 16S and 19S dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated mRNAs, 4982 with interferon, 2036 Sequence of oligonucleotide derived from 3' end of each of the four Low-molecular-weight peptide inhibits RNA synthesis in human brome mosaic viral RNAs, 4900 leukemic and phytohemagglutinin-stimulated leukocytes and globin Spliced segments at 5' terminus of adenovirus 2 late mRNA, 3171 mRNA transcription in differentiating Friend cells, 3869 5'-Terminal 7-methylguanosine and mRNA function: Influence of Molecular evolution of human and rabbit f-globin mRNAs, 5618 potassium concentration on translation in vitro, 3254 Nucleotide sequences of untranslated 5' regions of human a- and 5'-Terminal 7-methylguanosine and mRNA function: Influence of /-globin mRNAs, 5145 potassium concentration on translation in vitro (correction), 5198 Putative precursor of globin messenger RNA purified from mouse 5'-Terminal sequences and coding region of late simian virus 40 mRNAs nucleated erythroid cells, 178 are derived from noncontiguous segments of viral genome, 5323 Putative 15S precursor to /-globin mRNA but not to os-globin mRNA in 5'-Terminal structures of poliovirion RNA and poliovirus mRNA differ Friend cells, 3184 only in genome-linked protein VPg, 5345 Relative stability of a- and /1-globin messenger RNAs in homozygous /1+ Ribonucleic acid, messenger, vitellogenin thalassemia, 3960 Estrogen regulates the vitellogenin gene, 2384 Tadpole and adult globin RNA sequences in oocytes of Xenopus laeuis, Ribonucleic acid, messenger, Xenopus laevis 3835 mRNA-directed synthesis of catalytically active mouse /-glucuronidase Ribonucleic acid, messenger, histone in Xenopus oocytes, 4462 Histone gene transcription activated by nonhistone chromosomal Ribonucleic acid nucleotidyltransferase proteins in WI-38 human diploid fibreblasts, 173 Enzymatic initiation of DNA synthesis by yeast DNA polymerases, 1937 Ribonucleic acid, messenger, hormone-induced Localization of RNA polymerase in polytene chromosomes of Drosophila Hormone-inducible casein messenger RNA in serum-free organ culture melanogaster, 2079 of whole mammary gland, 2441 Phage T4-modified RNA polymerase transcribes T4 late genes in vitro, Ribonucleic acid, messenger, immunoglobulin 5305 Amino acid sequence of precursor region of MOPC-315 mouse Poliovirus-specific primer-dependent RNA polymerase able to copy immunoglobulin heavy chain, 5692 poly(A), 3677 Cloning of immunoglobulin variable region gene from mouse embryo, Virion-associated RNA polymerase required for bacteriophage N4 3518 development, 520 Hybridization properties of immunoglobulin mRNA: Failure to detect Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6) covalently associated IgG mRNA transcripts of reiterated and unique A gene from Escherichia coli affecting the sigma factor subunit of RNA mouse DNA, 3528 polymerase, 1836 Independent expression of gene coding for constant domain of Biological function of gramicidin: Selective inhibition of RNA immunoglobulin light chain: Sequence analyses of precursor of polymerase, 1478 constant region polypeptide, 3157 Chromosomal location of structural gene for RNA polymerase onfactor in Ribonucleic acid, messenger, interferon Escherichia coli, 1831 Induction and decay of human fibroblast interferon mRNA, 4415 DNA-dependent RNA polymerase involved in a recA-independent Interferon messenger RNA content of human fibroblasts during pathway of genetic recombination in Escherichia coli, 3932 induction, shutoff, and superinduction of interferon production, 3409 Electron microscope studies of transient complexes formed between Ribonucleic acid, messenger, mammalian Escherichia coli RNA polymerase holoenzyme and T7 DNA, 3740 Albumin synthesis in mouse uterus in response to liver mRNA, 1894 Fidelity of synthesis of preribosomal RNA in isolated nucleoli and Cellular mRNA degraded during infection by herpes simplex virus, 2370 nucleolar chromatin, 2446 Developmental control of messenger RNA for hepatic tryptophan Interaction between mutations of ribosomes and RNA polymerase: A 2,3-dioxygenase, 5392 pair of strA and rif mutants individually temperature-insensitive but Human placental lactogen mRNA and its structural genes during temperature-sensitive in combination, 1157 pregnancy: Quantitation with complementary DNA, 1024 In vitro synthesis of messenger RNA by a defective interfering particle Nascent prehormones are intermediates in biosynthesis of authentic of vesicular stomatitis virus, 1884 bovine pituitary growth hormone and prolactin, 2432 Mutant RNA polymerase in Escherichia coli: Regulation of synthesis Pregrowth hormone messenger RNA: Glucocorticoid induction and and activity, 5416 identification in rat pituitary cells, 2357 Polylysine used for adsorption of nucleic acids and enzymes to electron Translation in vitro of rat liver messenger RNA coding for ligandin microscope specimen films, 2311 (glutathione S-transferase B), 1899 Ribonuclease III cleavage of bacteriophage T3 RNA polymerase Ribonucleic acid, messenger, methylated transcripts to late T3 mRNAs, 4891 Importance of 5'-terminal blocking structure to stabilize mRNA in RNA polymerase binding sites in Xpilac5DNA, 4914 eukaryotic protein synthesis, 2734 Stereochemistry of polymerization by DNA-dependent RNA polymerase Ribonucleic acid, messenger, polyadenylylated from Escherichia coli: Investigation with a diastereomeric Analysis of polyoma virus nuclear RNA by mini-blot hybridization, 3138 ATP analogue (correction), 392 Identification of Rauscher murine leukemia virus-specific mRNAs for Structure of promoter for T7 RNA polymerase, 4266 synthesis of gag- and env-gene products, 1855 Transcription of Xenopus laevis 5S RNA genes in isolated chromatin by In vitro synthesis and processing of a putative precursor for the small purified RNA polymerase III, 44 subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas Ribonucleic acid, polyadenylylated reinhardtii, 1082 Interferon messenger RNA content of human fibroblasts during Ribonucleic acid, messenger, precursor induction, shutoff, and superinduction of interferon production, 3409 Evidence from UV transcription mapping in HeLa cells that Ribonucleic acid polymerase heterogeneous nuclear RNA is the messenger RNA precursor, 4520 see Ribonucleic acid nucleotidyltransferase Ribonucleic acid, messenger, purification Ribonucleic acid replication Multihormonal induction of hepatic a2u-globulin mRNA measured by Escherichia coli mutant with temperature sensitive function affecting hybridization to complementary DNA, 4791 bacteriophage Q/1RNA replication, 1657 Ribonucleic acid, messenger, somatotropin Terminal redundancy and origin of replication of Rous sarcoma virus Regulation of growth hormone gene expression: Synergistic effects of RNA, 1908 thyroid and glucocorticoid hormones, 4293 Ribonucleic acid, ribosomal Regulation of growth hormone messenger RNA by thyroid and Contrast variation study of specifically deuterated Escherichia coli glucocorticoid hormones, 1816 ribosomal subunits, 5547 Triiodothyronine stimulates specifically growth hormone mRNA in rat Escherichia coli 5S RNA binding proteins L18 and L25 interact with pituitary tumor cells, 2054 5.8S RNA but not with 5S RNA from yeast ribosomes, 2706 Ribonucleic acid, messenger, synthesis High-resolution proton magnetic resonance study of secondary structure Interferon production and interferon messenger RNA synthesis in of 3'-terminal 49-nucleotide fragment of 16S rRNA from Escherichia human fibroblasts, 1483 coli, 1028 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5847

Identification of spacer tRNA genes in individual ribosomal RNA virion structural proteins after microinjection of avian myeloblastosis transcription units of Escherichia coli, 2710 virus RNA, 3230 Identification of spacer tRNA genes in individual ribosomal RNA Glbucocorticoid-stimulated accumulation of mouse mammary tumor virus transcription units of Escherichia coli (correction), 4706 RNA: Increased rate of synthesis of viral RNA, 2879 Magnification of genes coding for ribosomal RNA in Saccharomyces Loss of infectivity of brome mosaic virus RNA after chemical cerevisiae, 1177 modification of 3' or 5' terminus, 2682 Methanogenic bacteria classified by 16S ribosomal RNA Nucleotide sequence surrounding a ribonuclease III processing site in characterization, 4537 bacteriophage T7 RNA, 984 Methanogenic bacteria classified by 16S ribosomal RNA characterization Partial deletion and substitution of src gene in RNA genome of avian (correction), 5778 sarcoma virus, 4781 Phylogenetic structure of prokaryotic domain: Primary kingdoms, 5088 Polypeptide synthesis initiated with various NH2-blocked Sequences homologous to ribosomal insertions occur in Drosophila aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5509 genome outside the nucleolus organizer, 4233 Protein covalently linked to poliovirus genome RNA, 59 Suppression of production of mouse 28S ribosomal RNA in Reconstitution of tobacco mosaic virus rods occurs bidirectionally from mouse-human hybrids segregating mouse chromosomes, 694 an internal initiation region: Demonstration by electron microscopic Transcriptionally active chromatin isolated from mammalian nucleoli, 69 serology, 1913 Ribonucleic acid structure Replication of pea enation mosaic virus RNA in isolated pea nuclei, 2919 Heterogeneous nuclear RNA secondary structure: Oligo(U) sequences Replication of viral RNA by defective interfering vesicular stomatitis base-paired with poly(A) and their possible role as bindimngsites for virus particle in absence of helper virus, 4387 heterogeneous nuclear RNA-specific proteins, 1426 Ribonuclease III cleavage of bacteriophage T3 RNA polymerase High-resolution proton magnetic resonance study of secondary structure transcripts to late T3 mRNAs, 4891 of 3'-terminal 49-nucleotide fragment of 16S rRNA from Escherichia RNA of avian acute leukemia virus MC29, 4320 coli, 1028 Rous sarcoma virus genome is terminally redundant: The 5' sequence, 5'-Terminal nucleotide sequence of Escherichia coli lactose repressor 989 mRNA: Features of translational initiation and reinitiation sites, 4163 Rous sarcoma virus genome is terminally redundant: The 3' sequence, Ribonucleic acid synthesis 994 Covalent linkage of a protein to a defined nucleotide sequence at Separation and infectivity of circular and linear forms of potato spindle 5'-terminus of virion and replicative intermediate RNAs of poliovirus, tuber viroid, 3859 961 Synthesis of full-length DNA copies of avian myeloblastosis virus RNA Dinucleoside pyrophosphates are substrates for T4-induced RNA ligase, in high yields, 2840 4839 Terminally repeated sequences in avian sarcoma virus RNA genome, Fidelity of synthesis of preribosomal RNA in isolated nucleoli and 2389 nucleolar chromatin, 2446 3' Terminus of RNA isolated from vesicular stomatitis virus and from its High-fidelity transcription of 5S DNA injected into Xenopus oocytes, defective interfering particles, 1353 2064 Tobacco necrosis virus and its satellite translated in a cell-free wheat Low-molecular-weight peptide inhibits RNA synthesis in human germ system, 2288 leukemic and phytohemagglutinin-stimulated leukocytes and globin Translation of 35S and subgenomic regions of avian sarcoma virus RNA, mRNA transcription in differentiating Friend cells, 3869 4661 Nucleoplasmic RNA: Definition of subclasses, 5011 Ribonucleoprotein Phage T4-modified RNA polymerase transcribes T4 late genes in vitro, Cytoplasmic nonpolysomal ribonucleoprotein particles in sea urchin 5305 embryos and their relationship to protein synthesis, 2231 RNA synthesis in isolated nuclei stimulated by partially purified Replication of viral RNA by defective interfering vesicular stomatitis preparations of simian virus 40 T-antigen, 3189 virus particle in absence of helper virus, 4387 Transcription of Xenopus laevis 5S RNA genes in isolated chromatin by Secondary structure of heterogeneous nuclear RNA: Two classes of purified RNA polymerase III, 44 double-stranded RNA in native ribonucleoprotein, 3705 Virion-associated RNA polymerase required for bacteriophage N4 Ribonucleoprotein particle development, 520 Heterogeneous nuclear RNA secondary structure: Oligo(U) sequences Ribonucleic acid terminus base-paired with poly(A) and their possible role as binding sites for Nucleotide sequence at 5' terminus of avian sarcoma virus genome, 1473 heterogeneous nuclear RNA-specific proteins, 1426 3' Terminus of RNA isolated from vesicular stomatitis virus and from its Ribosome defective interfering particles, 1353 Conditionally lethal ribosomal protein mutants: Locus required for Ribonucleic acid, transfer modification of 50S subunit proteins, 467 Aminoacyl-tRNA binding at recognition site is first step of elongation Contrast variation study of specifically deuterated Escherichia coli cycle of protein synthesis, 1903 ribosomal subunits, 5547 Asparaginyl-tRNA in regulation of asparagine synthetase in a Coordination of ribosome content and polysome formation during mammalian cell line, 2367 estradiol stimulation of vitellogenin synthesis in immature male chick Chemical basis for brain-specific serine transfer RNAs, 4243 livers, 3133 Codon specificity of UGA suppressor tRNATrP from Escherichia coli, Differential utilization of leucyl tRNAs by Escherichia coli, 1393 5496 Distribution of rat liver albumin RNA in membrane-bound and free Differential utilization of leucyl tRNAs by Escherichia coli, 1393 polyribosomes as determined by molecular hybridization, 5397 Hydrogen-bonded proton in tertiary structure of yeast tRNAPhe in Escherichia coli 5S RNA binding proteins L18 and L25 interact with solution, 1561 5.8S RNA but not with 5S RNA from yeast ribosomes, 2706 Identification of spacer tRNA genes in individual ribosomnalRNA Eukaryote ribosomes possess a binding site for concanavalin A, 818 transcription units of Escherichia coli, 2710 Extracellular labeling of nascent polypeptides traversing the membrane Identification of spacer tRNA genes in individual ribosomnalRNA of Escherichia coli, 2830 transcription units of Escherichia coli (correction), 4706 Guanosine 5'-diphosphate 3'-diphosphate: In vitro degradation, 5529 Inhibition of histidyl-tRNA-adenosine triphosphate Interaction between mutations of ribosomes and RNA polymerase: A phosphoribosyltransferase complex formation by histidine and by pair of strA and rif mutants individually temperature-insensitive but guanosine tetraphosphate, 1535 temperature-sensitive in combination, 1157 Isomeric aminoacyl-tRNAs are both bound by elongation factor Tu, 437 Interaction of rabbit reticulocyte ribosomes with bacteriophage fl Kinetic proofreading in aminoacylation of tRNA by synthetase, 2246 mRNA and of Escherichia coli ribosomes with rabbit globin mRNA, Nonintercalative binding of ethidium bromide to nucleic acids: Crystal 2692 structure of ethidium-tRNA molecular complex, 4821 Isopeptide linkage between N-a-monomethylalanine and lysine in Nonsense suppressors of yeast cause osmotic-sensitive growth, 305 ribosomal protein Sll from Escherichia coli, 4905 Nucleotide sequence of mutant eukaryotic gene: Yeast tyrosine-inserting Nucleic acid helix-unwinding properties of ribosomal protein S1 and role ochre suppressor SUP4-o, 5453 of S1 in mRNA binding to ribosomes, 2379 Peptide initiation: Partial reaction inhibited by phosphorylation of Proofreading of codon-anticodon interaction on ribosomes, 198 either initiation factor eIF-2 or 40S ribosomal proteins, 1445 Ribosomal mutations affect read-through of chain termination signal: Polypeptide synthesis initiated with various NH2-blocked Synthesis of bacteriophage X 0 gene protein in vitro, 689 aminoacyl-tRNAs under direction of alfalfa mosaic virus RNA 4, 5509 Ribosome structure: Localization of N6,N6-dimethyladenosine by Role of ribothymidine in mammalian tRNAPhe, 3696 electron microscopy of a ribosome-antibody complex, 1468 tRNATrP (bovine) binding to reverse transcriptase of avian Rotational relaxation of 70S ribosomes by a depolarization method using myeloblastosis virus and function as a heterologous primer, 1889 triplet probes, 1407 Ribonucleic acid tumor virus Shape of 50S subunit of Escherichia coli ribosomes, 2316 see also Oncornavirus Ribosome binding site Avian RNA tumor viruses: Heteroduplex analysis, 477 Rous sarcoma virus genome is terminally redundant: The 5' sequence, Type C RNA virus isolated from an established human histiocytic 989 lymphoma cell line, 2564 Ribosome recognition site Ribonucleic acid, viral Nucleotide sequences of ribosome recognition sites in messenger RNAs see also Ribonucleic acid, messenger, viral of vesicular stomatitis virus, 3672 Analysis of polyoma virus nuclear RNA by mini-blot hybridization, 3138 Ribosome release factor Assembly of tobacco mosaic virus in vitro: Elongation of partially DNA-directed synthesis in vitro of /-galactosidase: Requirement for reconstituted RNA, 552 ribosome release factor, 3217 Covalent linkage of a protein to a defined nucleotide sequence at Ribosylthymidine 5'-terminus of virion and replicative intermediate RNAs of poliovirus, Role of ribothymidine in mammalian tRNAthe, 3696 961 Ribothymidine Frog oocytes synthesize and completely process precursor polypeptide to see Ribosylthymidine Downloaded by guest on September 27, 2021 5848 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Ribulosebiphosphate carboxylase (EC 4.1.1.39) Hybrid tryptophan synthetase oachaino produced by genetic exchange In uitro symnthesisand processing of a putative precursor for the small between Escherichia coli and Salmonella typhimurium, 286 subunit of ribulose-1,5-bisphosphate carboxylase of Chlanmydononas Product of newly identified gene, glnF, is required for synthesis of rein,hardtii, 1082 glutamine synthetase in Salmonella, 1662 Ribulose-1,5-bisphosphate carboxylase Protein methyltransferase identified as cheR gene product in bacterial Chloroplast DNA distribution in parasexual hybrids shown by sensing system, 533 polypeptide composition of fraction I protUin, 5109 Transcription termination at trp, operon attenuators of Escherichia coli Random assembly of different kinds of small .:;ubunitpolypeptides and Salmonella typhimurium: RNA secondary structure and during formation of fraction I protein macromolccules, 3443 regulation of terminationm,4365 Ribulose bisphosphate carboxylase (EC 4.1.1.39) Use of a distant reporter grotupas evidemncefor comnformationalchange in Identification anodcloning of chloroplast gene coding for large subunit of' a sensory receptor, 1932 ribulose-1,5-bisphosphate carboxylase from Chl. mydomnonas Sarcolemma f'einharrdi,31.93 Isolation and characterization of muscle membranes using Maize chloroplast I)NA fragment encoding large s:ibunit of surface-specific labels, 34 ribulosebisphosphate carboxylase, 5487 Sarcoma Ribuolose-1,5-bisphosphate carboxylase-oxygenase structure: Form III Reduction of' syngeneic tumor growth by anti-I-J alloantiserum, 5118 crystals, 1037 Sarcoma virus, avian Ricci tensor Integration of avian sarcomnavirus DNA sequenmocesin transformed Calabi's conjecture and some new results in algebraic geometry, 1.798 mammalian cells, 4301 Riemannian manifold Nucleotide sequence at 5' terminus of avian sarcoma virtusgenome, 147:3 Analytic torsion and Reidemeister torsion, 2651 Partial deletion and substitution of src gene in RNA genome of avian Rifampicin sarcoma virus, 4781 Biogenoesis of poxviruses: Analysis of morphogenetic sequemnceusing a RNA of avian acute leukemia virus MC29, 4320 comnditionallethal mutant defective in envelope self-assembly, 2162 Terminally repeated sequemncesin avianosarcoma virus RNA genome, Virion-associated RNA polymera:.e required for bacteriophage N4 2389 dlevelopment, 520 Translation of 35S and subgenomic regions of avian sarcoma virus RNA, Rifampin 4661 l)NA-dependent RNA polymneraseinvolved in a recA-independent Sarcoma virus, feline p)athway of genetic recombination in E,cherichia coli, 3932 Feline oncornavirus-associated cell mrembraneantigein: Immunologically Rigid bicyclic ring crossreactive feline sarcoma virus-coded protein, 5608 Intramnolectulargeneral base-catalyzed ester hydrolyses by imidazolyl Sarcoma virus, Moloney group, 23 Cleavage map of linear mouse sarcoma virus DNA, 29 Intramolecular genoeralbase-catalyzed ester hydrolyses by imidazolyl Quantitative determinationmof transformed cells in a mixed population group (correction), 3621 by simultaneous fluoresceince analysis of cell surface and DNA in Rigor individual cells, 1626 Effi'ectof MgATP or stiffness measured at two frequencies in Sarcoma virus, murine Ca2+-activated munsclefibers, 4073 Suppressor cell regulationoof immune response to tumors: Abrogation by Ristocetin adult thymectomy, 2989 Cultured aortic enodothelial cells from pigs with von Willebrand disease: Sarcoma virus, Rous In uitro model for stutdying molecular defect(s) of the disease, 5702 Avian RNA tumor viruses: Heteroduplex analysis, 477 River Binding and internalization of thrombin by normal andl transf'ormecd 1976 Bedload measurements, East Fork River, Wyoming, 2644 chick cells, 596 Robust nonlinear data smoother Cell-free synthesis of two proteins unique to RNA of transf'ormimng IRol)ust nornlinear data smoothers: Definitions and recommendatiomns,434 virions of Rous sarcoma virus, 2011 Rotamer Cellular transformation and differentiation: Effect of Rous sarcoma virtus Stable conformnatioonsof aliphatic disulfides: Influence of' 1,4 interactions transformation on sulfated proteoglycan synthesis by chicken inivolving sulf'tr atoms, 13 chondrocytes, 4173 Rotational relaxation Cleavage of Rous sarcomnaviral polypeptide precursor into internal Rootational relaxation of 70S ribosomes by a depolarization method using structural proteinosin uitro involves viral proteinop15, 911 triplet probes, 1407 Factor that binds glucose and stimulates its transport isolated from Ruthenium normal and Rous sarcoma virus-transformed chicken fibroblasts, 163 Structture of transition-metal cluster compounds: Use of additional Glucose depletion accounts for induction of two transformation-sensitive orbital resulting frornm, g character of spd bond orbitals, 5235 membrane proteins in Rous sarcoma virtus-tranosformedchick embryo fibroblasts, 3840 In vitcrotranslation yields a possible Rous sarconmavirus src gene product, 3302 Saccharomyces cerevisiae I,evels of translatable mRNAs for cell surface protein, collagen Cell cycle of Saccharomyces cetevisiae in populations growing at precursors, and two membrane proteins are altered in Rous sarcoma different rates, 3850 virus-transformed chick embryo fibroblasts, 3399 Chromatin sulbunits from baker's yeast: Isolation and partial Role of surface modulating assemblies in growth conmtrolof normal and characterization, 1343 transformed fibroblasts, 666 I)evelopmental defects associated with glucosanmineauxotropy in Rous sarcoma virus genome is terminally redundant: 'Ihe 5' sequience, Saccharoomynocescereuisiae, 4351 989 Folded chromosomes isolated from yeast Saccharomyces cerevisiae, 2850 Rous sarcoma virtus genome is terminally redundant: The 3' sequence, Functional eukaryotic enzyme produced in Escherichia coli: Cloning and 994 expression of yeast structural gemnef'or imidazoleglycerolphosphate 'I'ermninalredundancy and origin of replication of Rous sarcoma virus dehydratase (his 3), 5255 RNA, 1908 (Genetic evidence for inodutcibilityof recombination competence in yeast, Sarcophaga bullata 1667 3':5'-Cyclic AMP and hormonal control of puparium formationoin fleshtly Moagnification of genes coding f'or ribosomal RNA in Saccharomyces Sarcophaga bullata, 2182 ccrt'visiaC', 1177 Role of ecdysone, pupariation factors, and cyclic AMI) in formationmand Notnsenosesuppressors of yeast cause osmotic-sensitive growth, 305 tanning of puparium of f'leshfly Sarcophaga bullata, 4697 Role of' moitotic replication genes in chromosome duplication during Schauder fixed-point theorem meiosis, 3951 Sharpened form of Schauder fixed-point theorem, 4749 Simple Menodelian inheritance of reiterated ribosomal DNA of yeast, Schizophrenia 5091 Brain dopamine receptors: Detection with [f3H]dihydroergocryptine, 3750 Sacculus Schwartz space Senositivity, polarity, and conductance change in responmseof vertebrate Fourier analysis on the Heisenberg group, 1328 hail cells to controlled mrechanical stimuli, 2407 Scrapie agent Saimiri sciureus Sedimenotation properties of scrapie agent, 4656 Endogenous new world primate retrovirus: Interspecies antigenic Scyllac equilibrium determinaniotsshared with major structural protein of type-D RNA Method of computational magnetohydrodynamics defining stable Scyllac virunsesof old world monokeys,5734 equilibria, 393 Saliva Sea snake Nerve growth factor inomotuse serum and saliva: Role of submandibular see Laticauda semifasciata gland, 2T330 Sea urchin Nerve growth factor in mouse serum and saliva: Role of submandibular see Anthocidaris crassispina; Arabacia punctulata; Lytechinus pictus; gland (correction), 4706 Strongylocentrotus purpuratus Nerve growth factor secreted in mouse saliva: Molecular properties, 2672 Secretion, defensive Salmonella Characterization and synthesis of volatile compounds for defensive (Concentration of msutagenrsfrom urine by adsorption with nonpolar resin secretions of "daddy longlegs" (Arachnida: Opiliones: Ileiobunum XAI)-2: Cigarette smokers have mutagenic urine, 3555 spp.), 419 Salmonella typhimurium Segregation distortion A gene fromnEscherichia coli affecting the sigma factor subunit of RNA Mechanism of genetic coadaptation in populations of I)rosophila polymerase, 1836 mnelanogaster, 324 tChromosomal location of' structural gene for RNA polymerase arfactor in Seismology Es/cherichia. coli, 1831 General variational principles applicable to the hybrid element method, 2595 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5849

Selection Role of sialic acid in survival of erythrocytes in circulation: Interaction of Genetic variability maintained under mutation and selection pressures in neuraminidase-treated and untreated erythrocytes with spleen and a finite population,2509 liver at cellular level, 1521 How does selection reconcile individual advantage with the good of the Sialidase group? 4542 see Neuraminidase Selective scatteringspectrum Sickle cell hemoglobin Selective scattering spectra as an approach to internal structure of granal see Hemoglobin S and agranal chloroplasts, 1455 Sickling Selenate 5'-Deoxypyridoxal as a potential anti-sickling agent, 1721 Derepression of ATP sulfurylase by sulfate analogs molybdate and Erythrocyte sickling inhibited in vitro by DL-glyceraldehyde, 367 selenate in cultured tobacco cells, 619 Ligand kinetics of hemoglobin S containing erythrocytes, 203 Semiconductivity Sigma factor Electronic properties of casein-methylglyoxal complex, 226 A gene from Escherichia coli affecting the sigma factor subunit of RNA Semisimple Lie group polymerase, 1836 Classification of irreducible representations of semisimple Lie groups, Chromosomal location of structural gene for RNA polymerase a factor in 2649 Escherichia coli, 1831 Reducibility criterion for generalized principal series, 5252 Signal peptidase Semliki Forest virus Post-translational cleavage of presecretory proteins with extract of rough Charge shift electrophoresis: Method for distinguishing between microsomes from dog pancreas containing signal peptidase activity, amphiphilic and hydrophilic proteins in detergent solution, 529 5598 Sendai virus Significant structure theory of liquids Cells reconstituted from cell fragments of two different species multiply Significant structure theory applied to phase separation, 10 and form colonies, 606 Silicon Enucleation and reconstruction of interferon-producing cells, 3391 n-Type Si-based photoelectrochemical cell: Liquid junction photocell Sendai virus-induced hemolysis: Reduction in heterogeneity of using a nonaqueous ferricenium/ferrocene electrolyte, 4116 erythrocyte lipid bilayer fluidity, 1918 Silk fibroin Specific action of T4 endonuclease V on damaged DNA in xeroderma Cloning of silk fibroin gene and its flanking sequences, 5363 pigmentosum cells in vivo, 2958 Silkmoth Sensation see Antheraea polyphemus Mysterious form of referred sensation in man, 4702 Silkworm Sensory adaptation see Bombyx mori Sensory transduction in Escherichia coli: Requirement for methionine in Simian virus 40 sensory adaptation, 183 Antigenic distinctions of glycoproteins in plasma and mitochondrial Sensoryelectrophysiology membranes of lymphoid cells neoplastically transformed by simian Sensory electrophysiology of bacteria: Relationship of membrane virus 40, 643 potential to motility and chemotaxis in Bacillus subtilis, 4752 Assignment of integration site for simian virus 40 to chromosome 17 in Sensorystimulation GM54VA, a human cell line transformed by simian virus 40, 315 Mysterious form of referred sensation in man, 4702 Cell-free translation of simian virus 40 early messenger RNA coding for Sensorytransduction viral T-antigen, 457 Cilia:Active role in sensorytransduction, 793 Contact-mediated communication compared in normal and transformed Sensitivity, polarity, and conductance change in response of vertebrate human cells in culture, 4476 hair cells to controlled mechanical stimuli, 2407 Division of BALB/c mouse 3T3 and simian virus 40-transformed 3T3 Serine cells in cellular aggregates, 3874 Chemical basis for brain-specific serine transfer RNAs, 4243 Early simian virus 40 transcriptional complexes: Late transcription in Serine protease absence of detectable DNA replication, 5443 Model for "charge-relay": Acceleration by carboxylate anion in Genetic analysis of host range mutant viruses stuggests uncoating defect intramolecular general base-catalyzed ester hydrolysis by imidazolyl in simian virus 40-resistant monkey cells, 3503 group, 2634 Histones: Metabolism in simian virus 40-infected cells and incorporation Proteolytic enzyme activation of rat ovarian adenylate cyclase, 4857 into virions, 2805 Spore coat processing and protein turnover altered in a Bacillus cereus Identification of simian virus 40 tumor and U antigens, 447 mutant with a defective postexponential intracellular protease, 1254 Immunologic selection against simian virus-40 transformed cells: Serology Concomitant loss of viral antigens and early viral gene sequences, 4796 Antibody to autologous human leukemia cells detected by immune Macrophage migration inhibitory activity generated by plasminogen adherence assays, 4587 activators, 1570 Serotonin Mapping of closed circular DNAs by cleavage with restriction Control of serotonin secretion from human platelets by hydroxyl ion endonucleases and calibration by agarose gel electrophoresis, 851 transport and osmotic lysis, 5295 Mapping of inverted repeated DNA sequences within genome of simian ,/-Endorphin: Development of tolerance and its reversal by virus 40, 1631 5-hydroxytryptophan in cats, 4017 Mapping of sequences with 2-fold symmetry on simian virus 40 genome: Serotonergic neurons in peripheral nervous system: Idemntificationin gut Photochemical crosslinking approach, 1363 by immunohistochemical localization of tryptophan hydroxylase, 3086 Mapping of transcription sites of simian virus 40-specific late 16S and SerotoninN-acetyltransferase 19S mRNA by electron microscopy, 496 see Arylamine acetyltransferase Polypeptides of cells transformed by RNA or DNA tumor viruses, 2729 Serum Purified DNAs are transcribed after microinjection into Xenopus Amyloid protein SAA is associated with high density lipoprotein from oocytes, 1502 human serum, 4025 Quantitative determination of transformed cells in a mixed population Serum,delipidated by simultaneous fluorescence analysis of cell surface and DNA in Morphological differentiation of neuroblastoma cells in medium individual cells, 1626 supplemented with delipidated serum, 3893 Regulatory function of simian virus 40 DNA replication for late viral Serumfactor gene expression, 4831 Endotoxin-induced serum factor controlling differentiation of Renaturation of complementary single-stranded DNA circles: Complete bone-marrow-derived lymphocytes, 1200 rewinding facilitated by DNA untwisting enzyme, 5328 Serum,human RNA maturation: Leader sequences of simian virus 40 mRNA are not Electron microscopy of negatively stained and freeze-etched high density transcribed adjacent to coding sequences, 3686 lipoprotein-3 from human serum, 5001 RNA synthesis in isolated nuclei stimulated by partially purified Severe combinedimmunodeficiency preparations of simian virus 40 T-antigen, 3189 Combined use of fetal liver and thymus for immunological reconstitution Sequence arrangement of 5' ends of simian virus 40 16S and 19S in patients with variants of severe combined immunodeficiency, 3002 mRNAs, 4982 Thymic activity in severe combined immunodeficiency diseases, 1250 Simian virus 40-specific proteins in membranes of simian virus Sex determination 40-transformed hamster and mouse cells, 5069 Human Y-chromosome-specific reiterated DNA in chromosome variants, Simian virus 40 tumor antigen purified from a line of simian virus 1245 40-transformed human cells, 3745 Sex factor Specific changes in collagen phenotype of BALB 3T3 cells: Result of Cell-cell interactions in conjugating Escherichia coli: Role of traT transformation by sarcoma viruses or a chemical carcinogen, 2933 protein in surface exclusion, 5104 Strand breakage by DNA untwisting enzyme results in covalent Sex ratio attachment of enzyme to DNA, 3800 How does selection reconcile individual advantage with the good of the Structure of a large segment of genome of simian virus 40 that does not group? 4542 encode known proteins, 827 Sexual selection Structure of a large segment of genome of simian virus 40 that does Parentalinvestment, mate choice, and mate quality, 3476 not encode known proteins (correction), 2594 Sheaf cohomologyvanishing theorem 5'-Terminal sequences and coding region of late simian virus 40 mRNAs Theorems of Barth-Lefschetz type for complex subspaces of are derived from noncontiguous segments of viral genome, 5323 homogeneous complex manifolds, 1332 Transformation by simian virus 40 induces virus-specific, related Shear stress antigens in surface membrane and nuclear envelope, 2495 Solid-like character of virus solutions, 1993 Tumorigenicity of simian virus 40-transformed human cells and Sialic acid mouse-human hybrids in nude mice, 1142 Glycolipid-boundsialic acid in serum:Increased levels in mice and Singular perturbation method humans bearing mammary carcinomas, 3011 Relaxationphenomena: A generaltreatment, 3623 Downloaded by guest on September 27, 2021 5850 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Skin Sphingomyelin Collagendegradation in rat skin but not in intestine duringrapid Immunogenicity of liposomal model membranes in mice: Dependence on growth: Effect on collagen types I and III from skin, 1436 phospholipid composition, 1234 Skin graft Spinal cord Selective reinnervation in skin-grafted Rana pipiens: Neurophysiological Immunocytochemical identification of substance P cells and their and behavioral evidence, 5749 processes in rat sensory ganglia and their terminals in spinal cord: Sleep Light microscopic studies, 3597 Delta-electroencephalogram(-sleep)-inducing peptide: Characterization, Ultrastructural identification of substance P cells and their processes in 1282 rat sensory ganglia and their terminals in spinal cord by Slime mold immunocytochemistry, 4050 see Dictyostelium discoideum Spin label Sobolev constant Lipid-protein interaction in phosphatidylcholine exchange protein, 1807 Analytic torsion and Reidemeister torsion, 2651 Membrane-controlled depletion of complement activity by Social structure spin-label-specific IgM, 3537 Rapid speciation and chromosomal evolution in mammals, 3942 Sendai virus-induced hemolysis: Reduction in heterogeneity of Sociobiology erythrocyte lipid bilayer fluidity, 1918 Parental investment, mate choice, and mate quality, 3476 Surface localization of sites of reduction of nitroxide spin-labeled Sodium molecules in mitochondria, 570 see also Transport, sodium Spin wave Batrachotoxin affects electroplax of electric eel: Voltage-dependent Explicit Plancherel theorem for ground state representation of interaction with sodium channels, 951 Heisenberg chain, 816 Bioelectricity and regeneration: Large currents leave stumps of Spleen regenerating newt limbs, 4528 Role of sialic acid in survival of erythrocytes in circulation: Interaction of Density of sodium channels in mammalian myelinated nerve fibers and neuraminidase-treated and untreated erythrocytes with spleen and nature of axonal membrane under myelin sheath, 211 liver at cellular level, 1521 Immunological distinction between acetylcholine receptor and Spleen endonuclease (EC 3.1.4.7) s-bungarotoxin-binding component on sympathetic neurons, 4689 Comparative subunit structure of HeLa, yeast, and chicken erythrocyte Physical-chemical approach to transient change in Na ion conductivity chromatin, 79 of excitable membranes (correction), 3621 Spleen focus-formingvirus Sodium-stimulated glutamate uptake in membrane vesicles of Friend strain of spleen focus-forming virus is recombinant between Escherichia coli: Role of ion gradients, 3167 ecotropic murine type C virus and env gene region of xenotropic type Sodium dodecylsulfate C virus, 4671 Moloney leukemia virus-induced cell surface antigen: Detection and Spleen necrosis virus characterization in sodium dodecyl sulfate gels, 5270 Infectious DNA of spleen necrosis virus is integrated at a single site in Solar energy DNA of chronically infected chicken fibroblasts, 281 n-Type Si-based photoelectrochemical cell: Liquid junction photocell Sponge using a nonaqueous ferricenium/ferrocene electrolyte, 4116 Current-induced flow through living sponges in nature, 2069 Solute Sporulation Use of solvent cavity area and number of packed solvent molecules Biological function of gramicidin: Gramicidin-negative mutants, 780 around a solute in regard to hydrocarbon solubilities and hydrophobic Control of development: Isolation of Bacillus subtilis mutants blocked interactions, 4144 early in sporulation and defective in synthesis of highly Solution phosphorylated nucleotides, 1125 Simultaneous measurements of viscosity and density in solutions Squalene undergoing change, 4430 Daily cholesterol synthesis rates in man measured by assay of fractional Solvent conversion of mevalonic acid to cholesterol, 3043 Use of solvent cavity area and number of packed solvent molecules Staphylococcalnuclease around a solute in regard to hydrocarbon solubilities and hydrophobic Chromatin subunits from baker's yeast: Isolation and partial interactions, 4144 characterization, 1343 Solvent channel Staphylococcusaureus Water molecules: Arrangement in cavities and channels of lattice of Replication and expression of plasmids from Staphylococcus aureus in [Phe4Val6]antamanide dodecahydrate, 2602 Bacillus subtilis, 1680 Somatosensoryperception Static permittivity Active touch exploration of extrapersonal space elicits specific Kinetic polarization deficiency in electrolyte solutions, 401 electrogenesis in right cerebral hemisphere of intact right-handed man, Statistical mechanics 4037 Microscopic theory of irreversible processes, 4152 Somatostatin Protein folding: Incorporation of a one-dimensional short-range (Ising) Glucose homeostasis during prolonged suppression of glucagon and model into a three-dimensional model, 1320 insulin secretion by somatostatin, 348 Theoretical study of effect of enzyme-enzyme interactions on Pancreatic immunoreactive somatostatin release, 2140 steady-state enzyme kinetics, 3632 Somatostatin-like immunoreactivity occurs in some peripheral Statistics sympathetic noradrenergic neurons, 3587 Age incidence curves for cancer, 1341 Transplantable insulinoma in rat, 628 Compound Poisson distribution: Prediction and estimation, 2670 Somatotropin Nonidentifiability in stochastic models of illness and death, 1338 /-Endorphin:Stimulation of growthhormone release in vivo, 358 Robust nonlinear data smoothers: Definitions and recommendations, 434 Human somatotropin: Restoration of full biological activity by Strong consistency of least-squares estimates in regression models, 2667 noncovalent interaction of natural and synthetic fragment of the Weather modification technology: Statistician's view (Review), 4714 hormone, 1016 Steady state Nascent prehormones are intermediates in biosynthesis of authentic Existence of a steady state in a biological system, 4182 bovine pituitary growth hormone and prolactin, 2432 Stein neighborhood Pregrowth hormone messenger RNA: Glucocorticoid induction and Complex submanifolds in real-analytic pseudoconvex hypersurfaces, 3126 identification in rat pituitary cells, 2357 Stereochemistry Regulation of growth hormone gene expression: Synergistic effects of Ethylphenacemide and phenacemide: Conformational similarities to thyroid and glucocorticoid hormones, 4293 diphenylhydantoin and stereochemical basis of anticonvulsant activity, Regulation of growth hormone messenger RNA by thyroid and 1264 glucocorticoid hormones, 1816 Intramolecular general base-catalyzed ester hydrolyses by imidazolyl Triiodothyronine stimulates specifically growth hormone mRNA in rat group, 23 pituitary tumor cells, 2054 Intramolecular general base-catalyzed ester hydrolyses by imidazolyl Speciation group (correction), 3621 Is evolution gradual or rectangular? Evidence from living fishes, 5083 Sterility, cytoplasmicmale Rapid speciation and chromosomal evolution in mammals, 3942 Unique DNA associated with mitochondria in "S"-type cytoplasm of Specific heat male-sterile maize, 2904 Single partition function for three phases, 2598 Steroid Spectrin see also Receptor, steroid Spectrin induced in erythroleumkemic cells transformed by Friend virus, Dephosphorylation inactivates glucocorticoid receptors, 1398 3898 Detection in bovine adrenal cortex of a lipoidal substance that yields Spectrum, visible pregnenolone upon treatment with alkali, 941 Pressure affects visible spectra of complexes of myoglobin, hemoglobin, Dissociation of tumor promoter-stimulated ornithine decarboxylase cytochrome c, and horse radish peroxidase, 1 activity and DNA synthesis in mouse epidermis in vivo and in vitro by Spencercohomology fluocinolone acetonide, a tumor-promotion inhibitor, 3908 Class of counterexamples to the integrability problem, 2655 Steroid d-isomerase(EC 5.3.3.1) Sperm Soluble glutathione-dependent d5-3-ketosteroid isomerase and Dynein identified as outer arms of sea urchin sperm axonemes, 5006 glutathione S-transferases of liver, 158 Isolation of bindin: Protein responsible for adhesion of sperm to sea Steroidogenesis urchin eggs, 2456 Gonadotropin-induced regulation of luteinizing hormone receptors and Sphericalharmonics desensitization of testicular 3':5'-cyclic AMP and testosterone Fourier analysis on the Heisenberg group, 1328 responses, 592 Intermediate role of adenosine 3':5'-cyclic monophosphate and protein Downloaded by guest on September 27, 2021 Proc. 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kinase during gonadotropin-induced steroidogenesis in testicular Surfacemodulating assembly interstitial cells, 3419 Role of surfacemodulating assemblies in growthcontrol of normaland Sterol biosynthesis transformedfibroblasts, 666 Animal cell mutants defective in sterol metabolism: Specific selection Surfacetension procedure and partial characterization of defects, 3730 Significantstructure theory appliedto liquid helium-3,4739 Stochasticmodel Survival Nonidentifiability in stochastic models of illness and death, 1338 Nonidentifiabilityin stochasticmodels of illness and death, 1338 Stochasticprocess Symmetricplane partition Random walks and generalized master equations with internal degrees of MacMahon'sconjecture on symmetricplane partitions,426 freedom, 430 Synapse Stoma Acetylcholine:Storage and releaseby a clonal cell line, 5184 Organic acid and potassium accumulation in guard cells during stomatal Cholinergicmetabolism and synapseformation by a rat nerve cell line, opening, 4434 2579 Storagedisease Dissociatedciliary ganglion neurons in vitro:Survival and synapse Phosphohexosyl components of a lysosomal enzyme are recognized by formation,5171 pinocytosis receptors on human fibroblasts, 2026 Muscarinicacetylcholine receptors in developingretina, 5524 Streptolydigin Phosphorylationof membraneproteins at cholinergicsynapse, 263 Phage T4-modified RNA polymerase transcribes T4 late genes in vitro, Protein relatedto tubulin identified in the postsynapticdensity, 1047 5305 Synapse turnover:Formation and terminationof transientsynapses, Streptomycin 4977 Translational error theory of aging, 3396 Synaptogenesis Streptozotocin Reinnervationof originalsynaptic sites on muscle fiber basement Streptozotocin-induced insulitis and diabetes, 2485 membraneafter disruptionof muscle cells, 3073 Stringentfactor Synaptosome Guanosine 5'-diphosphate 3'-diphosphate: In vitro degradation, 5529 Vasoactiveintestinal polypeptidein brain:Localization in and release Strongylocentrotuspurpuratus from isolated nerve termninals,3424 Cytoplasmic nonpolysomal ribonucleoprotein particles in sea urchin embryos and their relationship to protein synthesis, 2231 Isolation of bindin: Protein responsible for adhesion of sperm to sea Tanning urchin eggs, 2456 Role of ecdysone,pupariation factors, and cyclic AMP in formationand Release of ovoperoxidase from sea urchin eggs hardens fertilization tanning of pupariumof fleshfly Sarcophagabullata, 4697 membrane with tyrosine crosslinks, 4214 Tanning hormone Structureanalysis 3':5'-CyclicAMP and hormonalcontrol of pupariumformation in fleshfly Structure determination of gaseous and amorphous substances by Sarcophagabullata, 2182 diffraction methods: Philosophical concepts and their implementation T-antigen (Review), 4707 see Antigen,tumor Subellipticity Teratocarcinoma Sufficient conditions for subellipticity on weakly pseudo-convex Mosaicmice with teratocarcinoma-derivedmutant cells deficient in domains, 2214 hypoxanthinephosphoribosyltransferase, 5564 Submandibulargland Surfaceantigen in early differentiation,4449 Nerve growth factor in mouse serum and saliva: Role of submandibular Terminaldeoxynucleotidyltransferase gland, 2330 see Deoxyribonucleicacid nucleotidylexotransferase Nerve growth factor in mouse serum and saliva: Role of submandibular Terpene,methylcyclopentanoid gland (correction), 4706 Methylcyclopentanoidterpenes from larvaldefensive secretionof a Nerve growth factor secreted by L cells: Molecular properties, 1492 chrysomelidbeetle (Plagioderaversicolora), 2189 Nerve growth factor secreted in mouse saliva: Molecular properties, 2672 Territory Submaxillarygland Colony-specificterritorial pheromone in Africanweaver ant Oecophylla Genetic control of renin activity in submaxillary gland of' the mouse, longinoda (Latreille),2072 1185 Testis Pro-/-nerve growth factor, a biosynthetic precursor to 3-nerve growth Gonadotropin-inducedregulation of luteinizinghormone receptors and factor, 3647 desensitizationof testicular3':5'-cyclic AMP and testosterone Substance P responses,592 Immunohistochemical analysis of peptide pathways possibly related to 9S bindingprotein for androgensand progesterone,1960 pain and analgesia: Enkephalin and substance P, 3081 Selective associationof trout-specificH6 proteinwith chromatinregions Succinatedehydrogenase (EC 1.3.99.1) susceptibleto DNase I and DNase II: Locationof HMG-T in spacer 3-Nitropropionate, the toxic substance of Indigofera, is a stuicide regionbetween core nucleosomes,2810 inactivator of succinate dehydrogenase, 3767 Testosterone Sucrose Gonadotropin-inducedregulation of luteinizinghormone receptors and Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich desensitizationof testicular3':5'-cyclic AMP and testosterone in sucrose, 3038 responses,592 Fatty liver induced in Zucker "fatty" (ff) rats by semisynthetic diet rich Intermediaterole of adenosine3':5'-cyclic monophosphate and protein in sucrose (correction), 3550 kinase duringgonadotropin-induced steroidogenesis in testicular Sugar uptake interstitialcells, 3419 Sugar uptake and thymidine incorporation in mouse 3T3 cells stimulated 9S bindingprotein for androgensand progesterone,1960 by calcium phosphate and other extracellular particles, 5593 Serum sex hormonesand glucose,insulin, and lipid abnormalitiesin men Sugar uptake into brush border vesicles from normal human kidney, with myocardialinfarction, 1729 2825 Sex-limitedserum protein of Syrianhamsters: Definition of female Sulfate protein and regulationby testosterone,730 Derepression of ATP sulfurylase by sulfate analogs molybdate and Tetrad analysis selenate in cultured tobacco cells, 619 Simple Mendelianinheritance of reiteratedribosomal DNA of yeast, Sulfate adenylyltransferase (EC 2.7.7.4) 5091 Derepression of ATP sulfurylase by sulfate analogs molybdate and 12-0-Tetradecanoylphorbol-13-acetate selenate in cultured tobacco cells, 619 Dissociationof increasesin levels of 3':5'-cyclicAMP and 3':5'-cyclic Sulfhydryl GMP from inductionof ornithinedecarboxylase by tumor promoter Amino-acid sequence of myosin fragment that contains SH-1, SH-2, and 12-0-tetradecanoylphorbol-13-acetate in mouse epidermisin vivo, 657 Nr-methylhistidine, 4281 Tetrahydrofolatedehydrogenase (EC 1.5.1.3) Homoserine dehydrogenase: Spontaneous reactivation by dissociation of Codominantmarkers transferred by isolated metaphasechromosomes in p-mercuribenzoate from inactive enzyme-p-mercuribenzoate complex, Chinesehamster ovary cells, 3480 4862 Codominantmarkers transferred by isolated metaphasechromosomes in Sulfur-33 Chinesehamster ovary cells (correction),5776 Nuclear coupling of 33S and nature of free radicals in irradiated crystals Tetrahydropteroylglutamatemethyltransferase (EC 2.1.1.13) of N-acetyl-L-cysteine, 216 Intracellularbinding of radioactivehydroxocobalamin to Stable conformations of aliphatic disulfides: Influence of 1,4 interactions cobalamin-dependentapoenzymes in rat liver, 916 involving sulfur atoms, 13 Recognitionof two intracellularcobalamin binding proteins and their Supercoiling identificationas methylmalonyl-CoAmutase and methionine Elastic model of supercoiling, 2397 synthetase,921 Superconductivity Tetrahymenapyriformis Crystallography of new ternary borides, 1336 Ciliary rows: 180? rotation and its morphogenetic implications in Crystallography of new ternary borides (correction), 3621 Tetrahymena pyriformis, 1115 High superconducting transition temperatures of new rare earth ternary Tetrahymenathermophila borides, 1334 Direction of active sliding of microtubules in Tetrahymena cilia, 2045 Superoxidedismutase (EC 1.15.1.1) Tetrodotoxin Activation of guanylate cyclase by superoxide dismutase and hydroxyl Action potentials occur in cells of normal anterior pituitary gland and radical: Physiological regulator of guanosine 3':5'-monophosphate are stimulated by hypophysiotropic peptide thyrotropin-releasing formation, 4360 hormone, 4064 Superparamagnetism Thalassemia Surface, catalytic, and magnetic properties of small iron particles: Effect Authentic /-globin mRNA sequences in homozygous /?-thalassemia, of chemisorption of hydrogen on magnetic anisotropy, 806 3047 Downloaded by guest on September 27, 2021 5852 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Relative stability of a- and /-globin messenger RNAs in homozygous f/+ Immunological defect and its correction in osteopetrotic mutant rat, 339 thalassemia, 3960 Low-molecular-weight peptide inhibits RNA synthesis in human Thallium leukemic and phytohemagglutinin-stimulated leukocytes and globin Electrophilic mercuration and thallation of benzene and substituted mRNA transcription in differentiating Friend cells, 3869 benzenes in trifluoroacetic acid solution, 4121 Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: Thelytoky Evidence for T cell interactions, 5667 Evolutionary consequences of parthenogenesis: Evidence from the Mechanism of phosphorylation of synthetic polypeptides by calf thymus Warramaba virgo complex, 1130 cyclic AMP-dependent protein kinase, 4261 Thermal transition Suppressor cell regulation of immune response to tumors: Abrogation by Structure of human plasma low-density lipoproteins: Molecular adult thymectomy, 2989 organization of central core, 1042 Terminal deoxynucleotidyltransferase: Intracellular distribution in rat Thermodynamics bone marrow and thymus, 3993 Disagreement between calorimetric and van't Hoff enthalpies of 'Ihymic activity in severe combined immunodeficiency diseases, 1250 assembly of protein supramolecular structures, 2002 Thymosin al: Isolation and sequence analysis of immunologically active Heat capacity and entropy changes in processes involving proteins, 2236 thymic polypeptide, 725 Molecular events and energy changes during action potential, 3810 Thyroglobulin Significant structure theory applied to liquid helium-3, 4739 Spatial requirement for coupling of iodotyrosine residues to form thyroid Single partition function for three phases, 2598 hormones, 5333 Thermodynamics of self-association of glucagon, 3340 Thyroid Thermophile Pyrimidine dimers in DNA can give rise to tumors, 5574 Reconstitution of thermostable ATPase capable of energy coupling from Regulation of growth hormone gene expression: Synergistic effects of its purified subunits, 936 thyroid and glucocorticoid hormones, 4293 Thermostable sequence-specific endonuclease from Thermus aquaticus, Spatial requirement for coupling of iodotyrosine residues to form thyroid 542 hormones, 5333 Thermotaxis Thyroid stimulating hormone Thermotaxis by pseudoplasmodia of Dictyostelium discoideum, 2007 see Thyrotropin Thermus aquaticus Thyroliberin Thermostable sequence-specific endonuclease from Thermus aquaticus, Action potentials occur in cells of normal anterior pituitary gland and 542 are stimulated by hypophysiotropic peptide thyrotropin-releasing Thiol analog hormone, 4064 Inhibition of prostaglandin endoperoxide synthetase by thiol analogues Thyrotropin-releasing hormone-like material in rat retina: Changes due of prostaglandin, 144 to environmental lighting, 3579 Thiolase Thyrotropin see Acetyl-CoA acetyltransferase Effects of thyrotropin on thyroid cell membrane: Hyperpolarization Thrombin induced by hormone-receptor interaction, 2352 see also Prothrombin Thyrotropin-releasing hormone Binding and internalization of thrombin by normal and transformed see Thyroliberin chick cells, 596 Thyroxine Correlation of clotting protease activity in vitro and in vivo: Effect of Spatial requirement for coupling of iodotyrosine residues to form thyroid heparin, 3028 hormones, 5333 Interaction of coagulation factor Xa with human platelets, 4033 Time-series data Thrombogenesis Robust nonlinear data smoothers: Definitions and recommendations, 434 Prostaglandin I2 (prostacyclin) synthesized by cultured human and Tissue factor bovine endothelial cells, 3922 Activation of Factor IX by reaction product of tissue factor and Factor Thrombosis VII: Additional pathway for initiating blood coagulation, 5260 Correlation of clotting protease activity in vitro and in vivo: Effect of Tobacco heparin, 3028 see Nicotiana tabacum L. Human platelet factor 4: Amino acid sequence, 2256 Tobacco mosaic virus Thromboxane Assembly of tobacco mosaic virus in vitro: Elongation of partially lonophores stimulate prostaglandin and thromboxane biosynthesis, 4251 reconstituted RNA, 552 lonophores stimulate prostaglandin and thromboxane biosynthesis Inside-out model for self-assembly of tobacco mosaic virus, 149 (correction), 5778 Reconstitution of tobacco mosaic virus rods occurs bidirectionally from Synthesis of 13,14-dehydroprostacyclin methyl ester: Inhibitor of platelet an internal initiation region: Demonstration by electron microscopic aggregation, 21.99 serology, 1913 Thromboxane synthase Tobacco necrosis virus Resolution of prostaglandin endoperoxide synthase and thromboxane Tobacco necrosis virus and its satellite translated in a cell-free wheat synthase of human platelets, 3691 germ system, 2288 Thromboxane synthetase Tobacco necrosis virus satellite Imidazole: Selective inhibitor of thromboxane synthetase in human Tobacco necrosis virus and its satellite translated in a cell-free wheat platelets, 1716 germ system, 2288 Inhibition of human platelet thromboxane synthetase by a-Tocopherol 9,11-azoprosta-5,13-dienoic acid, 4007 Extension of lifespan of cultured normal human diploid cells by vitamin Thymic factor E: Reevaluation, 1640 Sequential stages of human T lymphocyte differentiation, 3414 Tonofilament Thymic activity in severe combined immunodeficiency diseases, 1250 Phalloidin-induced actin polymerization in cytoplasm of cultured cells Thymidine interferes with cell locomotion and growth, 5613 Sugar uptake and thymidine incorporation in mouse 3T3 cells stimulated Topology by calcium phosphate and other extracellular particles, 5593 Mathematical description of molecular structure: Molecular topology, Thymidine kinase 2616 Antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine: Selectivity of Toroidal limit set action, 5716 Hyperbolic almost periodic solutions and toroidal limit sets, 3124 Thymidine kinase (EC 2.7.1.21) Torque Deoxycytidine deaminase activity induced in mammalian cell lines by Simultaneous measurements of viscosity and density in solutions infection with herpes simplex virus type 1, 1734 undergoing change, 4430 Gene for thymidine kinase transferred to thymidine kinase-deficient Toxicity human cells by purified herpes simplex viral DNA, 1590 Food, drug, and cosmetic dyes: Biological effects related to lipid Thymine solubility, 2914 Contacts between lac repressor and thymines in lac operator, 4973 Toxin Thymocyte see also Bactrachotoxin; Endotoxin; Histrionicotoxin Ia antigens derived from murine thymocytes: Partial chemical Effects of thyrotropin on thyroid cell membrane: Hyperpolarization characterization, 1195 induced by hormone-receptor interaction, 2352 Ligand-independent cap formation: Redistribution of surface receptors Toxin, bee venom on mouse lymphocytes and thymocytes in hypertonic medium, 4511 Internal structural controls for evaluation of inactive synthetic peptide Secretion of mediators following T lymphocyte-macrophage interaction analogs: Synthesis of [Orn13,14]apamin and its guanidination to an is regulated by major histocompatibility complex, 3542 apamin derivative with full neurotoxic activity, 2771 Terminal deoxynucleotidyl transferase in thymocytes demonstrated by Toxin, cholera immunofluorescence, 734 see Choleragen Thymopoietin and thymic hormone levels in human plasma: Bioassay Toxin, diphtheria determinations, 2541 Diphtheria toxin: Relationship between structure and function, 472 Thymopoietin Gangliosides and substrate analogues affect hydrolysis of nicotinamide Thymopoietin and thymic hormone levels in human plasma: Bioassay adenine dinucleotide by choleragen, 74 determinations, 2541 Transcobalamin II Thymosin (aX Intracellular binding of radioactive hydroxocobalamin to Thymosin oi: Isolation and sequence analysis of immunologically active cobalamin-dependent apoenzymes in rat liver, 916 thymic polypeptide, 725 Recognition of two intracellular cobalamin binding proteins and their Thymus identification as methylmalonyl-CoA mutase and methionine Calcium dependence of glucocorticoid-induced lymphocytolysis, 638 synthetase, 921 Combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency, 3002 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5853

Transcription Cellular transformation and differentiation: Effect of Rous sarcoma virus DNA-directed synthesis in vitro of /-galactosidase: Requirement for transformation on sulfated proteoglycan synthesis by chicken ribosome release factor, 3217 chondrocytes, 4173 Early simian virus 40 transcriptional complexes: Late transcription in Changes in surface properties of normal and transformed cells caused by absence of detectable DNA replication, 5443 tunicamycin, inhibitor of protein glycosylation, 3433 Evidence from UV transcription mapping in HeLa cells that Chromatin protein appears during erythroid differentiation of Friend heterogeneous nuclear RNA is the messenger RNA precursor, 4520 virus-transformed cells, 653 Fidelity of synthesis of preribosomal RNA in isolated nucleoli and Chromatin protein appears during erythroid differentiation of Friend nucleolar chromatin, 2446 virus-transformed cells (correction), 3104 Genes transcribed at diverse rates have similar conformation in Contact-mediated communication compared in normal and transformed chromatin, 4867 human cells in culture, 4476 Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: Control of growth by picolinic acid: Differential response of normal and Increased transcription during erythroid differentiation, 2475 transformed cells, 2889 High-fidelity transcription of 5S DNA injected into Xenopus oocytes, Division of BALB/c mouse 3T3 and simian virus 40-tra'nsformed 3T3 2064 cells in cellular aggregates, 3874 Histone gene transcription activated by nonhistone chromosomal Epstein-Barr viral DNAs compared in Burkitt lymphoma biopsy cells proteins in WI-38 human diploid fibroblasts, 173 and in cells clonally transformed in vitro, 4651 Independent expression of gene coding for constant domain of Extensive disulfide bonding at mammalian cell surface, 2855 immunoglobulin light chain: Sequence analyses of precursor of Factor that binds glucose and stimulates its transport isolated from constant region polypeptide, 3157 normal and Rous sarcoma virus-transformed chicken fibroblasts, 163 Induction and decay of human fibroblast interferon mRNA, 4415 Gene for thymidine kinase transferred to thymidine kinase-deficient Inhibition of transcription and translation of globin messenger RNA in human cells by purified herpes simplex viral DNA, 1590 dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated Glucose depletion accounts for induction of two transformation-sensitive with interferon, 2036 membrane proteins in Rous sarcoma virus-transformed chick embryo Limited accessibility of chromatin satellite DNA to RNA polymerase fibroblasts, 3840 from Escherichia coli, 4337 Helper factor(s) for growth of adeno-associated virus in cells transformed Low-molecular-weight peptide inhibits RNA synthesis in human by adenovirus 12, 4508 leukemic and phytohemagglutinin-stimulated leukocytes and globin Host-determined differences in expression of surface marker mRNA transcription in differentiating Friend cells, 3869 characteristics on human and simian lymphoblastoid cell lines Maize chloroplast DNA fragment encoding large subunit of transformed by Epstein-Barr virus, 749 ribulosebisphosphate carboxylase, 5487 Identification of simian virus 40 tumor and U antigens, 447 Mapping of transcription sites of simian virus 40-specific late 16S and Immunologic selection against simian virus-40 transformed cells: 19S mRNA by electron microscopy, 496 Concomitant loss of viral antigens and early viral gene sequences, 4796 Multihormonal induction of hepatic ao2u-globulinmRNA measured by Integration of avian sarcoma virus DNA sequences in transformed hybridization to complementary DNA, 4791 mammalian cells, 4301 Mutant RNA polymerase in Escherichia coli: Regulation of synthesis Intestine as a source of apolipoprotein A1, 2574 and activity, 5416 Levels of translatable mRNAs for cell surface protein, collagen Nucleic acid regulatory sequences: Computer analysis, 4401 precursors, and two membrane proteins are altered in Rous sarcoma Nucleotide sequence of operator-promoter region of galactose operon of virus-transformed chick embryo fibroblasts, 3399 Escherichia coli, 106 Loss of growth control and differentiation in fu-i variant of L8 line of rat Phage T4-modified RNA polymerase transcribes T4 late genes in vitro, myoblasts, 3888 5305 Macrophage migration inhibitory activity generated by plasminogen Purified DNAs are transcribed after microinjection into Xenopus activators, 1570 oocytes, 1502 Polyoma virus T antigen: Characterization, 1259 Replication of viral RNA by defective interfering vesicular stomatitis Polypeptides of cells transformed by RNA or DNA tumor viruses, 2729 virus particle in absence of helper virus, 4387 Protease effects on specific growth properties of normal and transformed Retinoic acid (vitamin A acid) induced transcriptional control of baby hamster kidney cells, 2874 interferon production, 5382 Purified complement-fixing antigen identified as Epstein-Barr RNA synthesis in isolated nuclei stimulated by partially purified virus-determined nuclear antigen by its binding to metaphase preparations of simian virus 40 T-antigen, 3189 chromosomes, 1605 Role of ecdysone, pupariation factors, and cyclic AMP in formation and Quantitative determination of transformed cells in a mixed population tanning of puparium of fleshfly Sarcophaga bullata, 4697 by simultaneous fluorescence analysis of cell surface and DNA in Sites of transcription initiation in vivo on Xenopus laevis ribosomal individual cells, 1626 DNA, 5402 Rates of aggregation, loss of anchorage dependence, and tumorigenicity Structure of a large segment of genome of simian virus 40 that does not of cultured cells, 258 encode known proteins, 827 RNA synthesis in isolated nuclei stimulated by partially purified Structure of a large segment of genome of simian virus 40 that does preparations of simian virus 40 T-antigen, 3189 not encode known proteins (correction), 2594 Role of surface modulating assemblies in growth control of normal and Structure of promoter for T7 RNA polymerase, 4266 transformed fibroblasts, 666 5'-Terminal nucleotide sequence of Escherichia coli lactose repressor Simian virus 40-specific proteins in membranes of simian virus mRNA: Features of translational initiation and reinitiatio/n sites, 4163 40-transformed hamster and mouse cells, 5069 Transcription of Xenopus laevis 5S RNA genes in isolated chromatin by Simian virus 40 tumor antigen purified from a line of simian virus purified RNA polymerase III, 44 40-transformed human cells, 3745 Transcription termination at trp, operon attenuators of Esocherichia coli Specific changes in collagen phenotype of BALB 3T3 cells: Result of and Salmonella typhimurium: RNA secondary structure and transformation by sarcoma viruses or a chemical carcinogen, 2933 regulation of termination, 4365 Spectrin induced in erythroleumkemic cells transformed by Friend virus, tRNATrP (bovine) binding to reverse transcriptase of aviarn 3898 myeloblastosis virus and function as a heterologous primer, 1889 Transformation by simian virus 40 induces virus-specific, related Transformation antigens in surface membrane and nuclear envelope, 2495 Inhibitors of genetic recombination in pneumococci, 296 Transforming murine leukemia viruses isolated from mice with a high Transformation,genetic incidence of spontaneous lymphoma, 3065 Replication and expression of plasmids from Staphylococcus aureus in Tumorigenicity of simian virus 40-transformed human cells and Bacillus subtilis, 1680 mouse-human hybrids in nude mice, 1142 Thermosensitive step associated with transfer of Ti plasmid during Type 5 adenovirus DNA persists in cells transformed by a conjugation: Relation to transformation in crown gall, 2848 temperature-sensitive mutant, H5ts 125, 785 Transformationof cells, chemical Virion polypeptides identified in hamster cells transformed by herpes Chemicaltransformation of rat cell infected with xenotropictype-C simplex virus type 1, 372 RNA virus and its suppression by virus-specific antiserum, 579 Virus-specific proteins in plasma membrane of cells lytically infected or Heteroploid conversion of human skin cells by methylcholanthrene, 2451 transformed by polyoma virus, 4666 Partial inhibition of postreplication repair and enhanced frequency of Transglutaminase chemical transformation in rat cells infected with leukemia virus, 238 see also y-Glutamyltransferase Quantitative determination of transformed cells in a mixed population Transmembrane bridging proteins identified in plasma membrane of by simultaneous fluorescence analysis of cell surface and DNA in cultured mouse L cells, 5341 individual cells, 1626 Transhydrogenation Specific changes in collagen phenotype of BALB 3T3 cells: Result of Dehydrogenase and transhydrogenase properties of soluble NADH transformation by sarcoma viruses or a chemical carcinogen, 2933 dehydrogenase of bovine heart mitochondria, 846 Transformationof cells, viral Transition metal Antigenic distinctions of glycoproteins in plasma and mitochondrial Detailed electronic description of triple bonds between transition metal membranes of lymphoid cells neoplastically transformed. by simian atoms and verification by photoelectron spectroscopy, 3109 virus 40, 643 Transitionmoment coupling Assignment of integration site for simian virus 40 to chromrosome 17 in Circular dichroism of adenosine dinucleotides, 1785 GM54VA, a human cell line transformed by simian virus 40, 315 Translation Binding and internalization of thrombin by normal and transformed Cell-free translation of simian virus 40 early messenger RNA coding for chick cells, 596 viral T-antigen, 457 Catecholamine hormone receptor differences identified on 3T3 and Cytoplasmic nonpolysomal ribonucleoprotein particles in sea urchin simian virus-transformed 3T3 cells, 1091 embryos and their relationship to protein synthesis, 2231 Cell-freesynthesis of two proteinsunique to RNA of transforming Estrogen regulates the vitellogenin gene, 2384 virions of Rous sarcoma virus, 2011 Induction and decay of human fibroblast interferon mRNA, 4415 Downloaded by guest on September 27, 2021 5854 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Inhibition of transcription and translation of globin messenger RNA in Transportphenomenon dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated Random walks and generalized master equations with internal degrees of with interferon, 2036 freedom, 430 Ionic regulation in genetic translation systems, 1013 Transport, protein Levels of translatable mRNAs for cell surface protein, collagen Escherichia coli alkaline phosphatase precursor: Synthesis and precursors, and two membrane proteins are altered in Rous sarcoma processing in vitro, 1440 virus-transformed chick embryo fibroblasts, 3399 Gene fusions used to study outer membrane protein localization in Maize chloroplast DNA fragment encoding large subunit of Escherichia coli, 5411 ribulosebisphosphate carboxylase, 5487 Transport of a-amylase across basolateral membrane of pancreatic Mechanism of translational control by hemin in reticulocyte lysates, 3326 acinar cell, 4068 mRNA-dependent in vitro synthesis of ribosomal proteins L12 and L10 Transport,proton and elongation factor Tu, 5387 H+/ATP ratio during ATP hydrolysis by mitochondria: Modification of Nascent prehormones are intermediates in biosynthesis of authentic chemiosmotic theory, 1955 bovine pituitary growth hormone and prolactin, 2432 Transport,proximal tubule Nucleotide sequences of ribosome recognition sites in messenger RNAs Sugar uptake into brush border vesicles from normal human kidney, of vesicular stomatitis virus, 3672 2825 Rat liver factor that inhibits initiation of protein synthesis in rabbit Transport,retrograde axonal reticulocyte lysates, 2264 Nerve growth factor receptors: Identification of distinct classes in plasma Role of ecdysone, pupariation factors, and cyclic AMP in formation and membranes and nuclei of embryonic dorsal root neurons, 2785 tanning of puparium of fleshfly Sarcophaga bullata, 4697 Transport,sediment Specialized transducing phage for initiation factor 3 gene in Escherichia 1976 Bedload measurements, East Fork River, Wyoming, 2644 coli, 3970 Transport,sodium 5'-Terminal 7-methylguanosine and mRNA function: Influence of Abnormal lithium and sodium transport in erythrocytes of manic patient potassium concentration on translation in vitro, 3254 and some members of his family, 3607 5'-Terminal 7-methylguanosine and mnRNAfunction: Influence of Transport,uridine potassium concentration on translation in vitro (correction), 5198 Magnesium and calcium effects on uptake of hexoses and uridine by Tobacco necrosis virus and its satellite translated in a cell-free wheat chick embryo fibroblasts, 1585 germ system, 2288 Triacylglycerollipase (EC 3.1.1.3) Translational control by protein kinases in Artemia salina and wheat Activation of lipoprotein lipase by native and synthetic fragments of germ, 4356 human plasma apolipoprotein C-II, 4848 Translational error theory of aging, 3396 Lipoprotein lipase cofactor activity of a carboxyl-terminal peptide of Translation of 35S and subgenomic regions of avian sarcoma virus RNA, apolipoprotein C-II, 5358 4661 Trifluoroaceticacid Unwinding protein specific for mRNA translation fractionated together Electrophilic mercuration and thallation of benzene aind substituted with rabbit reticulocyte initiation factor 3 complex, 2325 benzenes in trifluoroacetic acid solution, 41.21 Translational inhibition Triglyceride 3':5'-Cyclic-AMP-dependent protein kinase in regulation of protein Activation of lipoprotein lipase by native and synthetic fragments of synthesis in reticulocyte lysates, 1463 human plasma apolipoprotein C-II, 4848 Peptide initiation: Partial reaction inhibited by phosphorylation of Serum sex hormones and glucose, insulin, and lipid abnormalities in men either initiation factor eIF-2 or 40S ribosomal proteins, 1445 with myocardial infarction, 1729 Transpiration Trigonometricpolynomial Organic acid and potassium accumulation in guard cells during stomatal Extended Watson integrals for cubic lattices, 1800 opening, 4434 Trihexosylceramide Transplantation Defects of glycosyltransferase activities in human fibroblasts of pk and p Antibody affinity enhanced in sublethally irradiated mice and bone blood group phenotypes, 5407 marrow chimeras, 707 Triiodothyronine Combined use of fetal liver and thymus for immunological reconstitution Regulation of growth hormone gene expression: Synergistic effects of in patients with variants of severe combined immunodeficiency, 3002 thyroid and glucocorticoid hormones, 4293 Growth of cultured cells from patients with Hodgkin's disease and Spatial requirement for coupling of iodotyrosine residues to form thyroid transplantation into nude mice, 754 hormones, 5333 Transport, active Triiodothyronine stimulates specifically growth hormone mRNA in rat Microenvironment of binding site in lac carrier protein, 1851 pituitary tumor cells, 2054 Transport, amino-acid Triiodothyroxin Amino-acid transport into Ehrlich cells: Unexpected additional mode of see also Hormone, thyroid energization, 1488 Trimethylaminedehydrogenase (EC 1.5.99.7) 3':5'-Cyclic AMP: Independent inductio/n of amino acid transport by Iron-sulfur cemnteridentified in trimethylamine dehydrogenase, 547 epinephrine in primary cultures of adult rat liver cells, 234 Trinitrophenyl- 3':5'-Cyclic AMP: Independent induction of amino acid transport by Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator epinephrine in primary cultures of adult rat liver cells (correction), cells crossreact with chemically modified syngeneic cells, 1229 2187 Triphenylmethylphosphonium Tritium suicide selection of mammalian cell mutants defective in Sensory electrophysiology of bacteria: Relationship of membrane transport of neutral amino acids, 4549 potential to motility and chemotaxis in Bacillus subtilis, 4752 Transport, anion Triplet probe Control of serotonin secretion from human platelets by hydroxyl ion Rotational relaxation of 70S ribosomes by a depolarization method using transport and osmotic lysis, 5295 triplet probes, 1407 Transport, cation Tripsacum Lithium efflux through Na/K pump in human erythrocytes, 3099 Pathways of genetic transfer from Tripsacum to Zea mays, 3494 Uncouplers and molecular mechanism of uncoupling in mitochondria, Trisomy 2241 Mosaic mice with teratocarcinoma-derived mutant cells deficient in Transport, electron hypoxanthine phosphoribosyltransferase, 5564 Dehydrogenase and transhydrogenase properties of soluble NADH Triton X-100 dehydrogenase of bovine heart mitochondria, 846 Molecular weight of bacteriorhodopsin solubilized in Triton X-100, 2803 Electron paramagnetic resonance studies of photosynthetic electron Tropomyosin transport: Photoreduction of ferredoxin and membrane-bound Major structural and regulatory proteins of chick muscle cells: Invariance iron-sulfur centers, 3826 and heterogeneity revealed by two-dimensional gel electrophoresis, Selective enrichment of photosynthetic electron transport mutants, 610 1450 Surface localization of sites of reduction of nitroxide spin-labeled Troponin-likecomplex molecules in mitochondria, 570 Troponin-like complex isolated from bovine brain cortex, 2273 Transport, glucose Trypsin Factor that binds glucose and stimulates its transport isolated from Conformational alteration of protein synthesis elongation factor EF-Tu normal and Rous sarcoma virus-transformed chicken fibroblasts, 163 by EF-Ts and by kirromycin, 3264 Magnesium and calcium effects on uptake of hexoses and uridine by Cryoenzymology in mixed solvents without cosolvent effects on enzyme chick embryo fibroblasts, 1585 specific activity, 2297 Sugar uptake into brush border vesicles from normal hunmankidney, Location of protein(s) involved in oligomycin-induced inhibition of 2825 mitochondrial adenosinetriphosphatase near outer surface of inner Transport,hydroxyl ion membrane, 4185 Control of serotonin secretion from human platelets by hydroxyl ion Protease effects on specific growth properties of normal and transformed transport and osmotic lysis, 5295 baby hamster kidney cells, 2874 Transport,ion Proteolytic enzyme activation of rat ovarian adenylate cyclase, 4857 Increased dexamethasone resistance of cystic fibrosis fibroblasts, 5642 Specific lysine labeling by 18OH during alkaline cleavage of Transport,lithium o-l-antitrypsin-trypsin complex, 4311 Abnormal lithium and sodium transport in erythrocytes of manic patient Trypsin (EC 3.4.21.4) and some members of his family, 3607 Enzymes as reagents in peptide synthesis: Enzyme-labile protection for Transport,passive carboxyl groups, 2739 (Cellular division in Escherichia coli: Mutant of E. coli lacking a Trypsin inhibitor, bovine pancreatic murein-lipoprotein, 1417 Protein folding: Incorporation of a one-dimensional short-range (Ising) model into a three-dimensional model, 1320 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5855

Tryptophan Tumorpromoter Mechanism of oxidation of tryptophan to formylkynurenine-25 years Dissociation of tumor promoter-stimulated ornithine decarboxylase later, 4730 activity and DNA synthesis in mouse epidermis in vivo and in vitro by Prelarge and presmall basic proteins in mouse myelin an(d their fluocinolone acetonide, a tumor-promotion inhibitor, 3908 structural relationship to large and small basic proteins, 3360 Tumor virus Tryptophan2,3-dioxygenase (EC 1.13.11.11) see also Mouse mammary tumor virus; Ribonucleic acid tumor virus Developmental control of messenger RNA for hepatic tryptophan Immune surveillance against virus-induced tumors and nonrejectability 2,3-dioxygenase, 5392 of spontaneous tumors: Contrasting consequences of host versus tumor Mechanism of oxidation of tryptophan to formylkynurenine-25 years evolution, 2121 later, 4730 Polypeptides of cells transformed by RNA or DNA tumor viruses, 2729 Tryptophan,5-hydroxy- Tunicamycin /-Endorphin:Development of toleranceand its reversalby Changes in surface properties of normal and transformed cells caused by 5-hydroxytryptophan in cats, 4017 tunicamycin, inhibitor of protein glycosylation, 3433 Tryptophanhydroxylase Turnip yellow mosaicvirus see Tryptophan 5-monooxygenase Solid-like character of virus solutions, 1993 Tryptophan5-monooxygenase (EC 1.14.16.4) Type C virus Serotonergic neurons in peripheral nervous system: Identification in gut see C-type virus by immunohistochemical localization of tryptophan hydroxylase, 3086 Tyrocidine Tryptophansynthase (EC 4.2.1.20) Isolation of amino acid activating subunit-pantetheine protein Hybrid tryptophan synthetase axchain produced by genetic exchange complexes: Role in chain elongation in tyrocidine synthesis, 2343 between Escherichia coli and Salmonella typhimurium, 286 Tyrosine Modified form of /2 subunit of Escherichia coli tryptophan synthetase Enzymic defects in hereditary tyrosinemia, 4641 suitable for investigating protein folding, 442 Nucleotide sequence of mutant eukaryotic gene: Yeast tyrosine-inserting Tryptophansynthetase ochre suppressor SUP4-o, 5453 see Tryptophan synthase Release of ovoperoxidase from sea urchin eggs hardens fertilization Tubularpresentation membrane with tyrosine crosslinks, 4214 Tubular presentations orof subsets of manifolds, 2209 Role of ecdysone,pupariation factors, and cyclic AMP in formationand Tubule tanning of puparium of fleshfly Sarcophaga bullata, 4697 Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic Tyrosine,azo- GMP in rat renal cortex: Effect of parathyroid hormone, 3569 Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: Nature Tubulin of the azotyrosyl-248-zinc complex, 3273 see also Antitubulin Tyrosinehydroxylase Addition of colchicine-tubulin complex to microtubule ends: Mechanism see Tyrosine 3-monooxygenase of substoichiometric colchicine poisoning, 3466 Tyrosine,iodo- Antibodies to tubulin in normal nonimmunized animals, 3997 Spatial requirement for coupling of iodotyrosine residues to form thyroid Disagreement between calorimetric and van't Hoff enthalpies of hormones, 5333 assembly of protein supramolecular structures, 2002 Tyrosinemia Guanosinetriphosphatase activity of tubulin associated with microtubule Enzymic defects in hereditary tyrosinemia, 4641 assembly, 5372 Tyrosine3-monooxygenase (EC 1.14.16.2) Immunofluorescent staining of cytoplasmic and spindle nicrotubules in Electrical stimulation of preganglionic nerve increases tyrosine mouse fibroblasts with antibody to T protein, 2437 hydroxylase activity in sympathetic ganglia, 3078 In vitro assembly of pure tubulin into microtubules in absemnceof Embryologic development of mouse sympathetic ganglion in vivo and in microtubule-associated proteins and glycerol, 1860 vitro, 3438 Microtubule structure at low resolution by x-ray diffraction, 3370 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Photoaffinity analog of GTP interacts with proteins of microtubules, activity by choline: Choline administration can increase cholinergic 4375 transmission, 798 Protein related to tubulin identified in the postsynaptic density, 1047 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Role of nucleotides in tubulin polymerization: Effect of guanylyl activity by choline: Choline administration can increase cholinergic 5'-methylenediphosphonate, 4881 transmission (correction), 2594 Stoichiometry of GTP hydrolysis and tubulin polymerization, 462 Tumor Activation of cytotoxic T cells by nonstimulating tumor cells and spleen UDPglucose:flavonoidglucosyltransferase cell factor(s), 4610 Controlling element-induced alterations in UDPglhscose:flavonoid Antibodies against influenza virus produced by somatic cell hybrids glucosyltransferase, the enzyme specified by bronze locus in maize, between mouse myeloma and primed spleen cells, 2985 5623 Antigen-specific purification of blocking factors from sera of mice with Uncoupler chemically induced tumors, 4605 Uncouplers and molecular mechanism of uncoupling in mitochondria, Bovine papilloma virus: Virus-specific DNA sequences in naturally 2241 occurring equine tumors, 524 Uracil Common precursor to corticotropins and endorphins, 3014 Transient accumulation of Okazaki fragments as a result of uracil Epigenetic variation of cultured somatic cells: Gradual changes in incorporation into nascent DNA, 154 requirement for factors promoting cell division, 2928 Uracil, bromo- Histaminase (diamine oxidase) activity in human tumors: Expression of Contacts between lac repressor and thymines in lac operator, 4973 a mature genome, 883 Urease (EC 3.5.1.5) Immune surveillance against virus-induced tumors and nonrejectability Kinetic and electrochemical memory in enzyme membramnes,5314 of spontaneous tumors: Contrasting consequences of host versus tumor Uridine evolution, 2121 see also Oligouridylate Isoantigenic expression of Forssman glycolipid in human gastric and Magnesium and calcium effects on uptake of hexoses and uridine by colonic mucosa: Possible identity with "A-like antigen" in human chick embryo fibroblasts, 1585 cancer, 3023 Uridine 5'-triphosphate Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: Effect of uridine on cellular UTP and glycogen synthesis in skeletal Evidence for T cell interactions, 5667 muscle: Stimulation of UTP formation by insulin, 2339 Mosaic mice with teratocarcinoma-derived mutant cells deficient in Urine hypoxanthine phosphoribosyltransferase, 5564 Concentration of mutagens from urine by adsorption with nonpolar resin Pyrimidine dimers in DNA can give rise to tumors, 5574 XAD-2: Cigarette smokers have mutagenic urine, 3555 Reduction of syngeneic tumor growth by anti-I-J alloantiserum, 5118 Urokinase Solid tumor models for assessment of different treatment modalities: Macrophage migration inhibitory activity generated by plasminogen Therapeutic strategy for sequential chemotherapy with radiotherapy, activators, 1570 1983 Uroporphyrinogen-Isynthase (EC 4.3.1.8) Suppressor cell regulation of immune response to tumors: Abrogation by 6-Aminolevulinate dehydratase, uroporphyrinogen-I synthase, and adult thymectomy, 2989 protoporphyrin IX: Levels in erythrocytes from anemic mutant mice, Thermosensitive step associated with transfer of Ti plasmid during 1181 conjugation: Relation to transformation in crown gall, 2848 Uterus Triiodothyronine stimulates specifically growth hormone mRNA in rat Albumin synthesis in mouse uterus in response to liver mRNA, 1894 pituitary tumor cells, 2054 Antipainand leupeptinrestrict uterine DNA synthesis and function in Tumorigenicity of five dihydrodiols of benz[a]anthracene on mouse skin: mice, 3754 Exceptional activity of benz[a]anthracene 3,4-dihydrodiol, 3176 Estradiol receptor of calf uterus: Interaction with heparin-agarose and Tumor promoters inhibit spontaneous and induced differentiation of purification, 4886 murine erythroleukemia cells in culture, 3451 c-Fetoprotein is not a component of estradiol receptor of rat uterus, Tumorigenesis 2269 Immunologic selection against simian virus-40 transformed cells: Concomitant loss of viral antigens and early viral gene sequences, 4796 Loss of growth control and differentiation in fu-l variant of Ls line of rat myoblasts, 3888 Vaccine, C-type virus Rates of aggregation, loss of anchorage dependence, and tumorigenicity Humoral immune response of NIH Swiss and SWR/J mice to vaccination of cultured cells, 258 with formalinized AKR or Gross murine leukemia virus, 343 Tumor immunology Vaccine, hepatitis B Rejection by syngeneic mice of cell variants obtained by mutagenesis of Hepatitis B surface antigen: Partial amino-acid sequence of two major teratocarcinoma cell line, 272 component polypeptides, 1530 Downloaded by guest on September 27, 2021 5856 Subject Index Proc. Natl. Acad. Sci. USA 74 (1977)

Vaccine, herpesvirus Vision, binocular Isolation of virus-free Herpesvirus saimiri antigen-positive plasma Effects of early experience upon orientation sensitivity and binocularity membrane vesicles, 2546 of neurons in visual cortex of cats, 1272 Vaccine, rabies Visual cortex In vitro evidence of cell-mediated immunity after exposure of mice to Effects of early experience upon orientation sensitivity and binocularity live and inactivated rabies virus, 334 of neurons in visual cortex of cats, 1272 Vaccinia virus Visual excitation Biogenesis of poxviruses: Analysis of morphogenetic sequence using a Rhodopsin in model membranes: Charge displacements in interfacial conditional lethal mutant defective in envelope self-assembly, 2162 layers, 207 DNA nicking-closing enzyme encapsidated in vaccinia virus: Partial Vitamin A purification and properties, 1841 see Retinal; Retinol Naturally occurring crosslinks in vaccinia virus DNA eliminated after Vitamin B-6 viral penetration into cells, 1739 see Pyridoxal 5'-phosphate Sites of transcription initiation in vivo on Xenopus laevis ribosomal Vitamin B-12 DNA, 5402 see Cobalamin; Cobalamin, adenosyl-; Cobalamin, hydroxo- 5'-Terminal 7-mnethylguanosine and mRNA function: Influence of Vitamin D potassium concentration on translation in vitro, 3254 Calcium translocation by Golgi and lateral-basal membrane vesicles from 5'-Terminal 7-methylguanosine and mRNA function: Influence of rat intestine: Decrease in vitamin D-deficient rats, 3612 potassium concentration on translation in vitro (correction), 5198 Vitamin E Valence bond theory see a-Tocopherol Structure of transition-metal cluster compounds: Use of additional Vitellogenin orbital resulting from f, g character of spd bond orbitals, 5235 Coordination of ribosome content and polysome formation during Valence, metallic estradiol stimulation of vitellogenin synthesis in immature male chick Covalence of atoms in the heavier transition metals, 2614 livers, 3133 Valinomycin Estrogen regulates the vitellogenin gene, 2384 Ionic requiremnentsfor induction of maturation (meiosis) in full-grown Voltage-dependent conductance and medium-sized Xenopus laevis oocytes, 3461 Synthesis of a 19-residue peptide with alamethicin-like activity, 115 Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by von Willebrand's disease its effects on cell membrane (correction), 392 Cultured aortic endothelial cells from pigs with von Willebrand disease: Variational principle In vitro model for studying molecular defect(s) of the disease, 5702 General variational principles applicable to the hybrid element method, Macromolecular Factor VIII complex: Functional and structural 2595 heterogeneity observed in von Willebrand swine with transfusion, 759 Vascular disease Biosyinthesis of type I and III collagens by cultured smooth muscle cells from human aorta, 671 Waldenstrom macroglobulin Vasoconstrictor Waldenstrom macroglobulin that is a cold agglutinin and a cryoglobulin Imnidazole:Selective inhibitor of thromboxane synthetase in human because it binds N-acetylneuraminosyl residues, 4591 platelets, 1716 Warramaba virgo Vasodilation Evolutionary consequences of parthenogenesis: Evidence from the Conformational requirements for dopamine-induced vasodilation, 3602 Warramaba virgo complex, 1130 Vasodilator Water Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin Water molecules: Arrangement in cavities and channels of lattice of methyl ester: Comparison with endoperoxides and other prostanoids, [Phe4Val6]antamanide dodecahydrate, 2602 5711 Water, heavy Vasopressin Heavy water as a tool for study of forces that control length of period of Neurophysin biosynthesis in normal rats and in rats with hereditary the 24-hour clock of hamsters, 1295 diabetes insipidus, 4046 Water vapor absorption Vesicle, dense core Site of water vapor absorption in desert cockroach, Arenivaga Acetylcholine: Storage and release by a clonal cell line, 5184 investigata, 1757 Vesicular stomatitis virus Water vapor permeability Glycoprotein of vesicular stomatitis virus: Synthesis and glycosylation in Reduction of pore area of avian eggshell as adaptation to altitude, 3095 vitro, 1516 Watson integral In vitro synthesis of messenger RNA by a defective interfering particle Extended Watson integrals for cubic lattices, 1800 of vesicular stomatitis virus, 1884 Wave Membrane assembly in vitro: Synthesis, glycosylation, and asymmetric Absorbing boundary conditions for numerical simulation of waves, 1765 inisertionmof transmembrane protein, 3278 Weather modification Nucleotide sequences of ribosome recognition sites in messenger RNAs Weather modification technology: Statistician's view (Review), 4714 of vesicular stomatitis virus, 3672 Wheat germ agglutinin Replication of viral RNA by defective interfering vesicular stomatitis Erythropoietin: Isolation by affinity chromatography with lectin-agarose virus particle in absence of helper virus, 4387 derivatives, 4633 3' Terminus of RNA isolated from vesicular stomatitis virus and from its Selective loss of wheat germ agglutinin binding to agglutinin-resistant defective interfering particles, 1353 mutants of Chinese hamster ovary cells, 5056 Vibrational effect Translational control by protein kinases in Artemia salina and wheat Heat capacity and entropy changes in processes involving proteins, 2236 germ, 4356 Vicia faba L. Wound healing Organic acid and potassium accumulation in guard cells during stomatal Density-dependent regulation of growth of BSC-1 cells in cell culture: opening, 4434 Control of growth by serum factors, 5046 Vinblastine Wright-Fisher model Guanosinetriphosphatase activity of tubulin associated with microtubule Error estimate for diffusion approximation of Wright-Fisher model, 5096 assembly, 5372 Nerve growth factor prevents vinblastine destructive effects on sympathetic ganglia in newborn mice, 5559 Xanthine oxidase (EC 1.2.3.2) Viral immunity Molybdenum cofactors from molybdoenzymes and in vitro reconstitution Specificity studies on cytotoxic thymus-derived lymphocytes reactive of nitrogenase and nitrate reductase, 5468 with influenza virus-infected cells: Dual recognition of H-2 and viral Xenopus laevis hemagglutinin amntigens,3006 Estrogen regulates the vitellogenin gene, 2384 Virus assembly Gene activation in somatic nuclei after injection into amphibian oocytes, Murine leukemia virus morphogenesis: Cleavage of P70 in vitro can be 2470 accompanied by shift from concentrically coiled internal strand High-fidelity transcription of 5S DNA injected into Xenopus oocytes, ("immature") to collapsed ("mature") form of virus core, 3446 2064 Virus encapsidation Identification of Rauscher murine leukemia virus-specific mRNAs for Reconstitution of tobacco mosaic virus rods occurs bidirectionally from synthesis of gag- and env-gene products, 1855 an internal initiation region: Demonstration by electron microscopic Sites of transcription initiation in vivo on Xenopus laevis ribosomal serology, 1913 DNA, 5402 Virus maturation Transcription of Xenopus laevis 5S RNA genes in isolated chromatin by Biogenesis of poxviruses: Analysis of morphogenetic sequence using a purified RNA polymerase III, 44 conditional lethal mutant defective in envelope self-assembly, 2162 Xenotropic virus Virus solution Antigen-specific nonimmunoglobulin factor that neutralizes xenotropic Solid-like character of virus solutions, 1993 virus is associated with mouse serum lipoproteins, 276 Viscosity Xeroderma pigmentosum Simultaneous measurements of viscosity and density in solutions Differences in removal of acetylaminofluorene and pyrimidine dimers undergoing change, 4430 from DNA of cultured mammalian cells, 1553 Vision Specific action of T4 endonuclease V on damaged DNA in xeroderma Nonlinear analysis of cat retinal ganglion cells in the frequency domain, pigmentosum cells in vivo, 2958 3068 Xiphophorus maculatus Primary photochemical event in vision: Proton translocation, 3119 Size-mediated onset of genetically determined maturation in platyfish, Xiphophorus maculatus, 4547 Downloaded by guest on September 27, 2021 Proc. Natl. Acad. Sci. USA 74 (1977) Subject Index 5857

X-ray absorption Yang-Mills equation X-ray absorption edge studies on oxidized and reduced cytochrome c Deformations of instantons, 2662 oxidase, 3821 Yang-Mills field X-ray absorption studies of halide binding to carbonic anhydrase, 1794 Minimal coupling and symplectic mechanics of a classical particle in X-ray crystallography presence of Yang-Mills field, 5253 Biologically active conformation of opiates and enkephalin, 5179 Yeast Ethylphenacemide and phenacemide: Conformational similarities to see Saccharomyces cerevisiae diphenylhydantoin and stereochemical basis of anticonvulsant activity, Y-organ 1.264 Secretion of ar-ecdysone by crab Y-organs in vitro, 615 Hydrophobicity, hydrophilicity, and radial and orientational distributions of residues in native proteins, 5248 Lactate dehydrogenase isozymes: Structural adaptations, 2677 Local interactions in bends of proteins, 4126 Method for obtaining a high resolution protein map starting from a low Zea mays resolution map, 2835 Controlling element-induced alterations in UDPglucose:flavonoid Neurotoxin a from venom of Philippines sea snake: Three-dimensional glucosyltransferase, the enzyme specified by bronze locus in maize, structure, 971 5623 X-ray diffraction Inheritance of selected pathotoxin resistance in maize plants regenerated Crystallographic studies of bovine /2-microglobulin, 3345 from cell cultures, 5113 Homology among acid proteases: Comparison of crystal structures at 3A Maize chloroplast DNA fragment encoding large subunit of resolution of acid proteases from Rhizopus chinensis and Endothia ribulosebisphosphate carboxylase, 5487 parasitica, 556 Pathways of genetic transfer from Tripsacum to Zea mays, 3494 Lipid and protein segregation in Escherichia coli membrane: Unique DNA associated with mitochondria in "S"-type cytoplasm of Morphological and structural study of different cytoplasmic membrane male-sterile maize, 2904 fractions, 452 Zinc Microtubule structure at low resolution by x-ray diffraction, 3370 Binding of Zn2+ to rat liver fructose-1,6-bisphosphatase and its effect on Nonintercalative binding of ethidium bromide to nucleic acids: Crystal catalytic properties, 2742 structure of ethidium-tRNA molecular complex, 4821 Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: Nature Pyridoxal phosphate: Location in glycogen phosphorylase a, 4757 of the azotyrosyl-248.zinc complex, 3273 Ribulose-1,5-bisphosphate carboxylase-oxygenase structure: Form III Zinc-binding ligands in milk and intestine: Role in neonatal nutrition? crystals, 1037 3547 Structure determination of gaseous and amorphous substances by Zymosan diffraction methods: Philosophical concepts and their imrnplementation Alternative complement pathway activated due to resistance of (Review), 4707 zymosan-bound amplification conivertase to endogenous regulatory Three-dimensional structure of intact human immunoglobulin, 5140 mechanisms, 1683 Downloaded by guest on September 27, 2021