Subject Index T O Volume 74

Total Page:16

File Type:pdf, Size:1020Kb

Subject Index T O Volume 74 Subject Index t o Volume 74 JANUARY-DECE MBER 1977 Introduction The terms in the Subject Index for Volu] ne 74, January-December 1977, of the PROCEEDINGS OF THE NATIONAL ACADEA [YOF SCIENCES USA were chosen from titles, key terms, and abstracts of articles. The index terms are alphabetized by computer; numbers, conformational prefix es, Greek letters, hyphens, and spaces between words are disregarded in alphabeti: zation. After each index term is printed the title of the article (or a suitable modifi( ation of the title) and the appropriate page number. Titles are listed in alphabeti cal order under the index terms. Classifications (e.g., Physics, Mathema tics) under which papers have been published are used as index terms only if it seemed this would be helpful. Papers that are concerned in some major way vvith methodology are indexed under "Methodology" as well as under more specifi c terms. Corrections to papers in which errors occurred are indexed under the term' 'Correction" as well as under the index terms selected for the paper itself. Organisn is are indexed by their scientific names when scientific names were provided in th e papers; suitable cross-references are provided. Because the PROCEEDINGS urges authoi s to follow the tentative rules and rec- ommendations of the nomenclature comr aissions (e.g., for biochemistry, those proposed by the International Union of I 'ure and Applied Chemistry and the Commission on Biochemical Nomenclature ), an effort has been made to construct an index that conforms with this policy. H )wever, correction of errors in nomen- clature was not attempted and the index sh ould not be looked upon as a reference for correct or recommended usage. In ad( lition, some exceptions to the recom- mendations of the commissions were necess. try. Index terms themselves are usually not abbreviated even if specific recommer ldations have been made by the com- missions; and in some instances, words withi: i an index term were rearranged. (Thus, tRNA is indexed as "Ribonucleic acid, tra nsfer.") In general, analogues of com- pounds are indexed as the parent compound . (Thus, dibutyryl adenosine 3':5'-cyclic monophosphate is indexed as "Adenosine 3' :5'-cyclic monophosphate, dibutyryl-.") The "Recommended Name" from the 1972 and 1975 recommendations of the In- ternational Union of Pure and Applied ChE mistry and the International Union of Biochemistry [Enzyme Nomenclature (197 3) and Supplement 1 (1975), American Elsevier, New York] has been used for enzyr -es whenever Enzyme Commission (EC) numbers were published in the papers. EC numbers are listed as part of the entry only if the EC number was printed in the paper. [Thus, some enzymes have two entries, e.g., "Adenosinetriphosphatase" and "Adenosinetriphosphatase (EC 3.6.1.3)."] 5781 Downloaded by guest on September 27, 2021 5782 SubjectIndex Proc. Natl. Acad. Sci. USA 74 (1977) PAGINATIOr [ OF ISSUES Pages Issue Month Pages Iss ue Month Pages Issue Month 1-392 1 January 1765-2188 5 May 3623-4110 9 September 393-800 2 February 2189--2594 6 June 4111-4706 10 October 801-1302 3 March 2595-3104 7 July 4707-5198 11 November 1303-1764 4 April 3105-3622 8 August 5199-5870 12 December Accident proneness Actin Compound Poisson distribution: Prediction and estimation, 2670 Actin microheterogeneity in chick embryo fibroblasts, 120 Acetic anhydride Antibody-induced linkages of plasma membrane proteins to intracellular Physical properties of chemically acetylated rat liver chromatin, 3244 actomyosin-containing filaments in cultured fibroblasts, 5584 Acetoacetyl CoA thiolase Calcium control of actin-activated myosin adenosine triphosphatase from see Acetyl-CoA acetyltransferase Dictyostelium discoideum (correction), 392 N- Acetoxy-2-acetylaminofluorene Defective organization of actin in cultured skin fibroblasts from patients Differences in removal of acetylaminofluorene and pyrimidine dimers with inherited adenocarcinoma, 3019 from DNA of cultured mammalian cells, 1553 HeLa cell poly(A)- mRNA codes for subset of poly(A)+ mRNA-directed Different rate-limiting steps in excision repair of ultraviolet- and proteins with actin as major product, 4801 N-acetoxy-2-acetylaminofluorene-damaged DNA in normal human Intracellular distributions of mechanochemical proteins in cultured fibroblasts, 1548 fibroblasts, 3883 Acetylchitobiose, di-N- Phalloidin-induced actin polymerization in cytoplasm of cultured cells Protein-sugar interactions: Preparation, purification, and properties of interferes with cell locomotion and growth, 5613 rabbit antibodies against di-N-acetylchitobiose, 168 Phosphorylation of smooth muscle myosin affects actin activation and Acetylcholine Ca2+ regulation, 129 see also Receptor, acetylcholine Transmembrane interactions and mechanism of capping of surface Acetylcholine: Storage and release by a clonal cell line, 5184 receptors by their specific ligands, 5031 Affinity alkylation labels two subunits of reduced acetylcholine receptor Actin, F from mammalian muscle, 4685 Interaction of filamin with F-actin in solutioin, 2021 Cholinergic metabolism and synapse formation by a rat nerve cell line, Actin-like protein 2579 Actin-like protein extracted from prokaryote Mycoplasma pneumoniae, Determination of transmitter function by neuronal activity, 5767 4041 Distinctions between two-state and sequential models for cooperative Actinomycin D ligand binding, 139 Biological function of gramicidin: Selective inhibition of RNA Dynamic properties of isolated acetylcholine receptor proteins: Release polymerase, 1478 of calcium ions caused by acetylcholine binding (correction), 1763 Induction and decay of human fibroblast interferon mRNA, 4415 Immunological distinction between acetylcholine receptor and Action potential a-bungarotoxin-binding component on sympathetic neurons, 4689 Action potentials occur in cells of normal anterior pituitary gland and Modulation of acetylcholine receptor by antibody against receptor, 3090 are stimulated by hypophysiotropic peptide thyrotropin-releasing Opposing effects of dopaminergic to cholinergic compounds on cerebral hormone, 4064 dopamine-activated adenylate cyclase, 769 Batrachotoxin affects electroplax of electric eel: Voltage-dependent Synaptic acetylcholine receptor sites identified in retina with interaction with sodium channels, 951 peroxidase-labeled a-bungarotoxin, 3268 Molecular events and energy changes during action potential, 3810 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Sensitivity, polarity, and conductance change in response of vertebrate activity by choline: Choline administration can increase cholinergic hair cells to controlled mechanical stimuli, 2407 transmission, 798 Subthreshold solutions of the Hodgkin-Huxley equations, 5199 Trans-synaptic induction of adrenomedullary tyrosine hydroxylase Actomyosin activity by choline: Choline administration can increase cholinergic Antibody-induced linkages of plasma membrane proteins to intracellular transmission (correction), 2594 actomyosin-containing filaments in cultured fibroblasts, 5584 Acetylcholinesterase Acupuncture Development of electrophysiological and biochemical membrane Mysterious form of referred sensation in man, 4702 properties during differentiation of embryonic skeletal muscle in Acyl-CoA synthetase (EC 6.2.1.3) culture, 5166 Candida lipolytica mutants defective in acyl-coenzyme A synthetase: Acetyl-CoA acetyltransferase (EC 2.3.1.9) Isolation and fatty acid metabolism, 4947 Cholesterol synthesis in rat adrenal gland regulated through coordinate Adaptation control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and Cost of evolution and imprecision of adaptation, 1647 reductase activities, 1421 Sensory transduction in Escherichia coli: Role of protein methylation Multi-enzyme complex of fatty acid oxidation isolated from Escherichia reaction in sensory adaptation, 4964 coli, 492 Adenine, 9-f-D-arabinofuranosyl- Acetyl-CoA carboxylase (EC 6.4.1.2) Conformational basis for activation of adenylate cyclase by adenosine, Acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in 2194 liver cell, 1497 Influence of 9-0-D-arabinofuranosyladenine on total protein synthesis fl-N-Acetylgalactosaminyltransferase (EC 2.4.1.79) and on differential gene expression of unique proteins in the rodent Defects of glycosyltransferase activities in human fibroblasts of pk and p malarial parasite Plasmodium berghei, 3386 blood group phenotypes, 5407 Adenine 5'-diphosphate ribosylation N-Acetylglucosamine Gangliosides and substrate analogues affect hydrolysis of nicotinamide Cell surface carbohydrates and proteins in cell behavior: Biochemical adenine dinucleotide by choleragen, 74 reversion of N-acetylglucosamine-deficient fibroblast mutant, 243 Adeno-associated virus Enzyme-substrate complexes of lysozyme: Structures, 2629 Helper factor(s) for growth of adeno-associated virus in cells transformed N-Acetylglucosamine incorporated into endogenous acceptors of rough by adenovirus 12, 4508 microsomes from rat liver: Stimulation by GTP after treatment with Adenocarcinoma pyrophosphate, 1095 Defective organization of actin in cultured skin fibroblasts from patients Acetyl transfer with inherited adenocarcinoma, 3019 Kinetic evidence for an intermediate in deacetylation of Establishment and characterization of a strain of human adrenal tumor monoacetyl-chymotrypsin, 510 cells that secrete estrogen, 1067 Achlya Adenomatosis of colon and rectum DNA sequence organization in water mold Achlya, 4332 Defective organization of actin in cultured
Recommended publications
  • Activation-Induced Deoxycytidine Deaminase (AID) Co-Transcriptional Scanning at Single-Molecule Resolution
    ARTICLE Received 19 Nov 2014 | Accepted 13 Nov 2015 | Published 18 Dec 2015 DOI: 10.1038/ncomms10209 OPEN Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution Gayan Senavirathne1,*, Jeffrey G. Bertram2,*, Malgorzata Jaszczur2,*, Kathy R. Chaurasiya3,4,*, Phuong Pham2, Chi H. Mak5,6, Myron F. Goodman2,5 & David Rueda1,3,4 Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA. Using single- molecule FRET, we show that AID binds to transcribed dsDNA and translocates unidirectionally in concert with RNA polymerase (RNAP) on moving transcription bubbles, while increasing the fraction of stalled bubbles. AID scans randomly when constrained in an 8 nt model bubble. When unconstrained on single-stranded (ss) DNA, AID moves in random bidirectional short slides/hops over the entire molecule while remaining bound for B5 min. Our analysis distinguishes dynamic scanning from static ssDNA creasing. That AID alone can track along with RNAP during transcription and scan within stalled transcription bubbles suggests a mechanism by which AID can initiate SHM and CSR when properly regulated, yet when unregulated can access non-Ig genes and cause cancer. 1 Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA. 2 Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA. 3 Department of Medicine, Section of Virology, Imperial College London, Du Cane Road, London W12 0NN, UK. 4 Single Molecule Imaging Group, MRC Clinical Sciences Center, Imperial College London, Du Cane Road, London W12 0NN, UK.
    [Show full text]
  • Human Cytogenetics Prenatal Diagnostics
    Cytogenetics Human Cytogenetics Prenatal Diagnostics Optimized Medium for Culture and Genetic Analysis of Human Amniotic Fluid Cells BIOAMF-1 and Chorionic Villi ( CV ) Samples Basal Medium and Supplement Chromosome Karyotyping was first developed in the BIOAMF-1 is designed for the primary culture of field of Cytogenetics. human amniotic fluid cells and chorionic villi (CV) The basic principle of the method is the preparation samples in both open (5% CO2) and closed systems. of chromosomes for microscopic observation by The medium allows rapid growth of amniocytes or arresting cell mitosis at metaphase with colchicine and treating the cells with a hypotonic solution. This chorionic villi for use in karyotyping. is followed by regular or fluorescent staining of the No supplementation with serum or serum- chromosomes, which are then tested with the aid of a substitutes is necessary. microscope and computer programs to arrange and The medium consists of two components: basal identify the chromosomes for the presence of genetic medium and frozen supplements. abnormalities. In principle, this method enables the identification Instructions for Use of any abnormality - excess chromosomes or For the preparation of 500ml complete medium, use chromosome deficiency, broken chromosomes, 01-190-1A with 01-192-1E. or excess genetic material (as a result of a For the preparation of 100ml complete medium, use recombination process). 01-190-1B with 01-192-1D. Clinical cytogenetics laboratories use this method Thaw the BIOAMF-1 Supplement by swirling in a with amniotic fluid, chorionic villi, blood cells, skin cells, and so on, which can be cell cultured to obtain 37ºC water bath, and transfer the contents to the mitotic cells.
    [Show full text]
  • Upregulation of Peroxisome Proliferator-Activated Receptor-Α And
    Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer Chih-Yang Wang, Ying-Jui Chao, Yi-Ling Chen, Tzu-Wen Wang, Nam Nhut Phan, Hui-Ping Hsu, Yan-Shen Shan, Ming-Derg Lai 1 Supplementary Table 1. Demographics and clinical outcomes of five patients with ampullary cancer Time of Tumor Time to Age Differentia survival/ Sex Staging size Morphology Recurrence recurrence Condition (years) tion expired (cm) (months) (months) T2N0, 51 F 211 Polypoid Unknown No -- Survived 193 stage Ib T2N0, 2.41.5 58 F Mixed Good Yes 14 Expired 17 stage Ib 0.6 T3N0, 4.53.5 68 M Polypoid Good No -- Survived 162 stage IIA 1.2 T3N0, 66 M 110.8 Ulcerative Good Yes 64 Expired 227 stage IIA T3N0, 60 M 21.81 Mixed Moderate Yes 5.6 Expired 16.7 stage IIA 2 Supplementary Table 2. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of an ampullary cancer microarray using the Database for Annotation, Visualization and Integrated Discovery (DAVID). This table contains only pathways with p values that ranged 0.0001~0.05. KEGG Pathway p value Genes Pentose and 1.50E-04 UGT1A6, CRYL1, UGT1A8, AKR1B1, UGT2B11, UGT2A3, glucuronate UGT2B10, UGT2B7, XYLB interconversions Drug metabolism 1.63E-04 CYP3A4, XDH, UGT1A6, CYP3A5, CES2, CYP3A7, UGT1A8, NAT2, UGT2B11, DPYD, UGT2A3, UGT2B10, UGT2B7 Maturity-onset 2.43E-04 HNF1A, HNF4A, SLC2A2, PKLR, NEUROD1, HNF4G, diabetes of the PDX1, NR5A2, NKX2-2 young Starch and sucrose 6.03E-04 GBA3, UGT1A6, G6PC, UGT1A8, ENPP3, MGAM, SI, metabolism
    [Show full text]
  • Bovine Coccidiosis - a Review
    PEER REVIEWED Bovine Coccidiosis - A Review DL Step, DVM, DACVIM; RN Streeter, DVM, MS, DACVIM; JG Kirkpatrick, DVM, DABVP Department of Veterinary Clinical Sciences, Boren Veterinary Teaching Hospital, Oklahoma State University, Stillwater, OK 74078 Abstract mune en hiver meme dans les cas de confinement. Les :feces peuvent contenir des oocystes meme lorsque les Coccidians are protozoa! parasites that are host animaux ne montrent pas de signes cliniques de sorte specific, transmitted by the fecal-oral route and cause qu'un diagnostic de coccidiose doit se baser sur les signes enteritis. Economically significant species discussed in cliniques et exclure les autres maladies. L'identification this paper that cause disease in cattle belong to the ge­ post-mortem de coccidies aide a supporter le diagnostic. nus Eimeria. Young animals are more susceptible to Les elements de regie qui reduisent le stress et clinical disease than older cattle. Coccidiosis is fre­ previennent la contamination de l'eau et de la nourriture quently observed in stressed, overcrowded and confined sont importants pour prevenir la coccidiose. Les conditions, however, .the disease can occur on pasture. programmes de controle efficaces incluent souvent The disease can occur any time of the year but is more !'utilisation de nourriture et d'eau medicamentes. Les prevalent during winter months, even in confinement agents antimicrobiens couramment utilises aux Etats­ operations. Animals may pass oocysts in their feces with­ Unis pour le controle et la prevention de coccidiose out clinical disease, therefore, a diagnosis of coccidiosis incluent entre autres le monensin, le lasalocide, le is based on clinical signs and ruling out other diseases.
    [Show full text]
  • Difluorodeoxycytidine 5'-Triphosphate: a Mechanism of Self-Potentiation1
    ICANCER RESEARCH 52, 533-539, February 1, 1992] Cellular Elimination of 2',2'-Difluorodeoxycytidine 5'-Triphosphate: A Mechanism of Self-Potentiation1 Volker Heinemann,2 Y¡-ZhengXu, Sherri Chubb, Alina Sen, Larry W. Hertel, Gerald B. Grindey, and William Plunkett1 Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 [V. H., Y. X., S. C., A. S., W. P.], and Lilly Research Laboratories, Indianapolis, Indiana 46285 (L. W. H., G. B. G.] ABSTRACT less, clinical cellular pharmacology studies have demonstrated 2',2'-Difluorodeoxycytidine (dFdC, Gemcitabine) is a deoxycytidine that the dFdCTP:dCTP value reaches potentially inhibitory analogue which, after phosphorylation to the 5'-di- and 5'-triphosphate values during clinical trials (4, 10, 11). (b) dFdCTP is incor porated into DNA by DNA polymerases a and f, inhibiting (dFdCTP), induces inhibition of DNA synthesis and cell death. We examined the values for elimination kinetics of cellular dFdCTP and further elongation (9). (c) Once incorporated, dFdCMP resi found they were dependent on cellular concentration after incubation of dues in the terminal or penultimate positions of the DNA strand CCRF-CEM cells with dFdC and washing into drug-free medium. When inhibit the editing function of DNA polymerase <(9). This may the drug was washed out at low cellular dFdCTP levels (<50 n\\), fix damage caused by the incorporated analogue, (d) dFdCDP dFdCTP elimination was linear (t,: = 3.3 h), but it became biphasic at inhibits ribonucleotide reducíase,blocking DNA synthesis by intracellular dFdCTP levels >100 JIM. Although the initial elimination decreasing the cellular concentrations of deoxynucleoside tri rate was similar at all concentrations, at higher concentrations the phosphates (12-14).
    [Show full text]
  • Identification of Compounds That Rescue Otic and Myelination
    RESEARCH ARTICLE Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant Elvira Diamantopoulou1†, Sarah Baxendale1†, Antonio de la Vega de Leo´ n2, Anzar Asad1, Celia J Holdsworth1, Leila Abbas1, Valerie J Gillet2, Giselle R Wiggin3, Tanya T Whitfield1* 1Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom; 2Information School, University of Sheffield, Sheffield, United Kingdom; 3Sosei Heptares, Cambridge, United Kingdom Abstract Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate versican gene expression and morphogenesis is disrupted. We have designed a whole-animal screen that tests for rescue of both up- and down-regulated gene expression in mutant embryos, together with analysis of weak and strong alleles. From a screen of 3120 structurally diverse compounds, we have identified 68 that reduce versican b expression in the adgrg6 mutant ear, 41 of which also restore myelin basic protein gene expression in Schwann cells of mutant embryos. Nineteen compounds unable to rescue a strong adgrg6 allele provide candidates for molecules that may interact directly with the Adgrg6 receptor. Our pipeline provides a powerful approach for identifying compounds that modulate GPCR activity, with potential impact for future drug design. DOI: https://doi.org/10.7554/eLife.44889.001 *For correspondence: [email protected] †These authors contributed Introduction equally to this work Adgrg6 (Gpr126) is an adhesion (B2) class G protein-coupled receptor (aGPCR) with conserved roles in myelination of the vertebrate peripheral nervous system (PNS) (reviewed in Langenhan et al., Competing interest: See 2016; Patra et al., 2014).
    [Show full text]
  • Report Name:Ukraine's Mrls for Veterinary Drugs
    Voluntary Report – Voluntary - Public Distribution Date: November 05,2020 Report Number: UP2020-0051 Report Name: Ukraine's MRLs for Veterinary Drugs Country: Ukraine Post: Kyiv Report Category: FAIRS Subject Report Prepared By: Oleksandr Tarassevych Approved By: Robin Gray Report Highlights: Ukraine adopted several maximum residue levels (MRLs) for veterinary drugs, coccidiostats and histomonostats in food products of animal origin. Ukraine also adopted a list of drugs residues that are not allowed in food products. THIS REPORT CONTAINS ASSESSMENTS OF COMMODITY AND TRADE ISSUES MADE BY USDA STAFF AND NOT NECESSARILY STATEMENTS OF OFFICIAL U.S. GOVERNMENT POLICY The Office of Agricultural Affairs of USDA/Foreign Agricultural Service in Kyiv, Ukraine prepared this report for U.S. exporters of domestic food and agricultural products. While every possible care was taken in the preparation of this report, information provided may not be completely accurate either because policies have changed since the time this report was written, or because clear and consistent information about these policies was not available. It is highly recommended U.S. exporters verify the full set of import requirements with their foreign customers, who are normally best equipped to research such matters with local authorities, before any goods are shipped. This FAIRS Subject Report accompanies other reports on Maximum, Residue Limits established by Ukraine in 2020. Related reports could be found under the following links: 1.) Ukraine's MRLs for Microbiological Contaminants_Kyiv_Ukraine_04-27-2020 2.) Ukraine's MRLs for Certain Contaminants_Kyiv_Ukraine_03-06-2020 Food Products of animal origin and/or ingredients of animal origin are not permitted in the Ukrainian market if they contain certain veterinary drugs residues in excess of the maximum residue levels established in Tables 1 and 2.
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9,642,912 B2 Kisak Et Al
    USOO9642912B2 (12) United States Patent (10) Patent No.: US 9,642,912 B2 Kisak et al. (45) Date of Patent: *May 9, 2017 (54) TOPICAL FORMULATIONS FOR TREATING (58) Field of Classification Search SKIN CONDITIONS CPC ...................................................... A61K 31f S7 (71) Applicant: Crescita Therapeutics Inc., USPC .......................................................... 514/171 Mississauga (CA) See application file for complete search history. (72) Inventors: Edward T. Kisak, San Diego, CA (56) References Cited (US); John M. Newsam, La Jolla, CA (US); Dominic King-Smith, San Diego, U.S. PATENT DOCUMENTS CA (US); Pankaj Karande, Troy, NY (US); Samir Mitragotri, Santa Barbara, 5,602,183 A 2f1997 Martin et al. CA (US); Wade A. Hull, Kaysville, UT 5,648,380 A 7, 1997 Martin 5,874.479 A 2, 1999 Martin (US); Ngoc Truc-ChiVo, Longueuil 6,328,979 B1 12/2001 Yamashita et al. (CA) 7,001,592 B1 2/2006 Traynor et al. 7,795,309 B2 9/2010 Kisak et al. (73) Assignee: Crescita Therapeutics Inc., 8,343,962 B2 1/2013 Kisak et al. Mississauga (CA) 8,513,304 B2 8, 2013 Kisak et al. 8,535,692 B2 9/2013 Pongpeerapat et al. (*) Notice: Subject to any disclaimer, the term of this 9,308,181 B2* 4/2016 Kisak ..................... A61K 47/12 patent is extended or adjusted under 35 2002fOOO6435 A1 1/2002 Samuels et al. 2002fOO64524 A1 5, 2002 Cevc U.S.C. 154(b) by 204 days. 2005, OO 14823 A1 1/2005 Soderlund et al. This patent is Subject to a terminal dis 2005.00754O7 A1 4/2005 Tamarkin et al.
    [Show full text]
  • Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance
    cells Review Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance Ronay Cetin 1,† , Eva Quandt 2,† and Manuel Kaulich 1,3,4,* 1 Institute of Biochemistry II, Goethe University Frankfurt-Medical Faculty, University Hospital, 60590 Frankfurt am Main, Germany; [email protected] 2 Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195 Barcelona, Spain; [email protected] 3 Frankfurt Cancer Institute, 60596 Frankfurt am Main, Germany 4 Cardio-Pulmonary Institute, 60590 Frankfurt am Main, Germany * Correspondence: [email protected]; Tel.: +49-(0)-69-6301-5450 † These authors contributed equally to this work. Abstract: Drug resistance is a commonly unavoidable consequence of cancer treatment that results in therapy failure and disease relapse. Intrinsic (pre-existing) or acquired resistance mechanisms can be drug-specific or be applicable to multiple drugs, resulting in multidrug resistance. The presence of drug resistance is, however, tightly coupled to changes in cellular homeostasis, which can lead to resistance-coupled vulnerabilities. Unbiased gene perturbations through RNAi and CRISPR technologies are invaluable tools to establish genotype-to-phenotype relationships at the genome scale. Moreover, their application to cancer cell lines can uncover new vulnerabilities that are associated with resistance mechanisms. Here, we discuss targeted and unbiased RNAi and CRISPR efforts in the discovery of drug resistance mechanisms by focusing on first-in-line chemotherapy and their enforced vulnerabilities, and we present a view forward on which measures should be taken to accelerate their clinical translation. Citation: Cetin, R.; Quandt, E.; Kaulich, M. Functional Genomics Keywords: chemotherapy resistance; cancer and drug vulnerabilities; functional genomics; RNAi Approaches to Elucidate Vulnerabilities of Intrinsic and and CRISPR screens Acquired Chemotherapy Resistance.
    [Show full text]
  • B Number Gene Name Mrna Intensity Mrna Present # of Tryptic
    list list sample) short list predicted B number Gene name assignment mRNA present mRNA intensity Gene description Protein detected - Membrane protein detected (total list) detected (long list) membrane sample Proteins detected - detected (short list) # of tryptic peptides # of tryptic peptides # of tryptic peptides # of tryptic peptides # of tryptic peptides Functional category detected (membrane Protein detected - total Protein detected - long b0003 thrB 6781 P 9 P 3 3 P 3 0 homoserine kinase Metabolism of small molecules b0004 thrC 15039 P 18 P 10 P 11 P 10 0 threonine synthase Metabolism of small molecules b0008 talB 20561 P 20 P 13 P 16 P 13 0 transaldolase B Metabolism of small molecules b0009 mog 1296 P 7 0 0 0 0 required for the efficient incorporation of molybdate into molybdoproteins Metabolism of small molecules b0014 dnaK 13283 P 32 P 23 P 24 P 23 0 chaperone Hsp70; DNA biosynthesis; autoregulated heat shock proteins Cell processes b0031 dapB 2348 P 16 P 3 3 P 3 0 dihydrodipicolinate reductase Metabolism of small molecules b0032 carA 9312 P 14 P 8 P 8 P 8 0 carbamoyl-phosphate synthetase, glutamine (small) subunit Metabolism of small molecules b0048 folA 1588 P 7 P 1 2 P 1 0 dihydrofolate reductase type I; trimethoprim resistance Metabolism of small molecules peptidyl-prolyl cis-trans isomerase (PPIase), involved in maturation of outer b0053 surA 3825 P 19 P 4 P 5 P 4 P(m) 1 GenProt membrane proteins (1st module) Cell processes b0054 imp 2737 P 42 P 5 0 0 P(m) 5 GenProt organic solvent tolerance Cell processes b0071 leuD 4770
    [Show full text]
  • Octopine Synthase Mrna Isolated from Sunflower Crown Gall Callus Is
    Proc. Nati Acad. Sci. USA Vol. 79, pp. 86-90, January 1982 Biochemistry Octopine synthase mRNA isolated from sunflower crown gall callus is homologous to the Ti plasmid of Agrobacterium tumefaciens (recombinant plasmid/hybridization/mRNA size/in vitro translation/immunoprecipitation) NORIMOTO MURAI AND JOHN D. KEMP Department of Plant Pathology, University ofWisconsin, and Plant Disease Research Unit, ARS, USDA, Madison, Wisconsin 53706 Communicated by Folke Skoog, September 14, 1981 ABSTRACT We have shown that the structural gene for oc- families have been identified. The enzymes responsible for the topine synthase (a crown gall-specific enzyme) is located in a cen- synthesis of the first two have been purified and characterized tral portion ofthe T-DNA that came from the Ti plasmid ofAgro- (17, 18). bacterium tumefaciens and is expressed after it has been trans- The particular opine family present in a crown gall cell cor- ferred to the plant cells. Polyadenylylated RNA was prepared relates with a particular Ti plasmid rather than with the host from polysomes isolated from an octopine-producing crown gall plant (19, 20). Analysis ofdeletion mutants of an octopine-type callus and purified by selective hybridization to one offive recom- Ti plasmid has shown that a gene controlling octopine produc- binant plasmids. Each such plasmid contained a different frag- tion is located on a 14.6-kbp fragment ofthe T-DNA generated ment ofT-DNA ofpTi-15955 (octopine-type Ti plasmid). Purified by Sin 1 (21) (Fig. 1). Detailed examination ofthe physical or- mRNA was translated in vitro in rabbit reticulocyte lysates, and ganization of T-DNA in octopine-type tumor lines has shown the translation products were immunoprecipitated with antibody that octopine production is correlated with the presence ofthe against octopine synthase.
    [Show full text]