ANALGESKS Differential Regulation of Mu and Delta Opiate Receptors by J. E. Zadina, L. M. Harrison, L.-J. Ge, 1086 Morphine, Selective Agonists and Antagonists and A. J. Kastin and S. L. Chang Differentiating Agents in SH-SYSY Human Neuroblastonia Cells Endogenous Opioids Released by Suspending Mice by the Forrest L. Smith, David A. Brase, 1177 Daniel Dombrowski and Tail Selectively Enhance Spinal Mu Opioid Analgesia S. William L. Dewey Downloaded from Genetic Analysis of Sensitization and Tolerance to Cocaine Bryan K. Tolliver, John K. Belknap, 1230 William E. Woods and John M. Carney Biochemical and Pharmacological Characterfration of Mu, Kelly M. Standifer, Jie Cheng, 1246 Delta and Kappa3 Opiold Receptors Expressed in BE(2)-C Andrew I. Brooks, Carlo P. Honrado, Neuroblastoma Cells Wendy Su, Luisa M. Visconti,

June L. Biedler and Gavril W. Pasternak jpet.aspetjournals.org ‘-Tetrahydrocannabino1 Enhances the Secretion of Weigang Zhu, Catherine Newton, 1334 Interleukin 1 from Endotoxin-Stimulated Macrophages Yehia Daaka, Herman Friedman and Thomas W. Klein Molecular Mechanisms of Agonist-Induced Desensitization of Karen Raynor, Haeyoung Kong, 1381 the aoned Mouse Kappa Oploid Receptor John Hines, Guanghui Kong, Jeffrey Benovic, Kazuki Yasuda,

Graeme I. Bell and Terry Reisine at ASPET Journals on October 6, 2021

AUTONOMIC PHARMACOLOGY The Endothelium of the Rat Renal Artery Plays an Pauline L. Martin and Alice Anne Potts 893 Obligatory Role in A2 Adenosine Receptor-Mediated Relaxation Induced by 5’-N-Ethylcarboxamidoadenosine and N’-Cyclopentyladenoslne Spinal Cholinergic Alpha-2 Adrenergic Interactions in Anand Lothe, Ping Li, Chuanyao Tong, 1301 Analgesia and Hemodynamic Centrol: Role of Muscarinic Young Yoon, Herv#{233}Bouaziz, Receptor Subtypes and NItrIC Oxide Dawn J. Detweiler and James C. Eisenach

BEHAVIORAL PHARMACOLOGY Possible Involvement of the Activation of Voltage-Sensitive Kiyofumi Yamada, Shinobu Nakayama, 881 Calcium Channels in the Ameliorating Effects of Nefiracetam Tadashi Shiotani, Takaaki Hasegawa on ScopolamIne-Induced impairment of Performance in a and Toshitaka Nabeshima Passive Avoidance Task BehaviOral Effects of 6-Methylene Naltrexone (Nalinefene) in Charles P. France and Lisa R. Gerak 992 Rhesus Monkeys Behavioral Effects of the Systemically Active Delta Oploid S. Stevens Negus, Eduardo R. Butelman, 1025 Kwen-Jen Chang, Brian DeCosta, Agonist BW373U86 in Rhesus Monkeys Gail Winger and James H. Woods Pharmacological Characterization of the Novel Discriminative Philip Terry, Jeffrey M. Witkin and 1041 Stimulus Effects of a Low Dose of Cocaine Jonathan L. Katz Behavioral Effects of the Dopamine Autoreceptor Agonist Kimberly E. Vanover and 1049 PD 128483 Alone and in Combination with Cocaine William L. Woolverton Effects of Dopamine on Prolactin: Interactions with Cocaine Nancy K. Mello, Jack H. Mendelson, 1110 Self-Administration by Female Rhesus Monkeys John M. Drieze, Slew Koon Teoh, Maureen L. Kelly and J. Wallis Sholar

Contents continued on iv Contents continued from iii CARDIOVASCULAR PHARMACOLOGY .- Inhibition of Nitric Oxide Synthase Prevents Myocardial J. Craig Hartman, Gary M. Kurc, 1071 Protection by Ramiprilat Thomas G. Hullinger, Theron M. Wall, Rita M. Sheehy and Ronald J. Shebuski Modulation of Renal Vasoconstrictor Effect of NGNifre-L All F. Hajj-ali, Thomas M. Reilly and 1152 Arginine in Rabbit by Angiotensin II and Alpha-i Adrenergic Pancras C. Wong Receptor Blockade Effect of Protein Kinase C on Cyclic 3’,5’-Adenosine Hon-Chi Lee, John J. Cal and 1171 Monophosphate-Dependent Phosphodiesterase in Hongwei Yu Hypertrophlc Cardiomyopathic Hamster Hearts p InhIbition of In Vii’o Myocardial Ischemic and Reperfusion Shawn C. Black, Charles S. Schasteen, 1208 Injury by a Synthetic Manganese-Based Superoxide Randy H. Weiss, Dennis P. Riley, Dismutase Mimetic Edward M. Driscoll and Benedict R. Lucchesi

CELLULAR AND MOLECULAR PHARMACOLOGY Effects of KT-362, a New Antiarrhythmic Agent, on Yuan-Na Cheng, Tatsuto Kiyosue and 851 Membrane Ionic Currents of Guinea Pig Ventricular Makoto Arita Downloaded from Myocytes Endothelin Receptors: Binding and Phosphoinositide M. Breuiller-Fouch#{234}, V. H#{233}luy, 973 Breakdown in Human Myometrium T. Fournier and F. Ferr#{233} Potentiation of ‘y-Aminobutyric AcidA Receptor Cl- Current Sheryl A. Zimmerman, Mathew V. Jones 987 Correlates with In Vivo Anesthetic Potency and Neil L. Harrison Xanthlne Oxidase Inhibits Transmembrane Signal Donald E. Wesson and Stephen J. Effiott 1197 jpet.aspetjournals.org Transduction in Vascular Endothelial Cells KN-62, a Specific Ca/Calmodulin-Dependent Protein Katsuo Okazaki, Tomohiko Ishikawa, 1319 Kinase Inhibitor, Reversibly Depresses the Rate of Beating of Makoto Inui, Michihiko Tada, Cultured Fetal Mouse Cardiac Myocytes Kiyota Goshima, Tadashi Okamoto and Hiroyoshi Hidaka

CHEMOTHERAPY at ASPET Journals on October 6, 2021 Pharmacokinetics and Bioavailability Study of Ethacrynic Frank P. LaCreta, James M. Brennan, 1186 Acid as a Modulator of Drug Resistance in Patients with Sherrie L. Nash, Robert L. Comis, Cancer Kenneth D. Tew and Peter J. O’Dwyer Interleukln-1j8-Mediated Metallothionein Induction and Yukihiro Kondo, Shiu-Ming Kuo and 1313 Cytoprotection Against Cadmium and cis- John S. Lazo Dlammlnedlchloroplatlnum

DRUG METABOLISM AND DISPOSITION Metabolism of Vesnarinone by Activated Neutrophils: Jack P. Uetrecht, Nasir Zahid and 865 Implications for Vesnarinone-Induced Agranulocytosis Dennis Whitfield Ethinylestradlol Interacts with Liver Microsomes and Induces Leandro Fern#{225}ndez, Luis D. Boada, 1121 Octavio P. Luzardo, Manuel Zumbado, Binding Sites for Steroid Hormones in the Male Rat Liver Juan C. Dlaz-Chico, Bonifacio N. Dlaz-Chico and Ricardo Chirino Molybdate Depletes Hepatic 3-Phosphoadenosine 5- Takiko Oguro, Zolt#{225}nGregus, 1145 Phosphosulfate and Impairs the Sulfation of Acetaminophen Cherukury Madhu, Lan Liu and in Rats Curtis D. Klaassen The Pharniacodynamics and Pharmacokinetics of the James E. Caldwell, Janos Szenohradszky, 1216 Metabolite 3-Desacetylvecuronium (ORG 7268) and its Veronica Segredo, Peter M.C. Wright, Parent Compound, Vecuronium, in Human Volunteers Cormac McLoughlin, Manohar L. Sharina, Larry D. Gruenke, Dennis M. Fisher and Ronald D. Miller Selective Suppression of Rat Hepatic Cytochrome P450 2C11 James C. Kraner, Edward T. Morgan 1367 by Chioramphenicol and James R. Halpert

Contents continued on v Contents continuedfrom iv

ENDOCRINE PHARMACOLOGY Arginine Vasopressin-Stimulated Insulin Secretion and Ter-Hsin Chen, Bumsup Lee and 900 Elevation of Intracellular Ca Concentration in Rat Walter H. Hsu Insullnoma Cells: Influences of a Phospholipase C Inhibitor 1-(6417-methoxyestra-l,3,5(10)-trien-17-ylJaminoJhexyl}. 1H-pyrrole-2,5-dlone (U-73122) and a Phospholipase A2 Inhibitor N-(p-Amylclnnamoyl)anthranilic Acid Cocaine Effects on Pulsatile Secretion of ACTH in Men Siew Koon Teoh, Zoltan Sarnyai, 1134 Jack H. Mendelson, Nancy K. Mello, Sandra A. Springer, J. Wallis Sholar, Michel Wapler, John C. Kuehnle and Howard Gelles

GASTROINTESTINAL PHARMACOLOGY Effects of Lovastatin in Humans on Biliary Lipid Composition William C. Duane 841 and Secretion as a Function of Dosage and Treatment Interval Fedotozine Reversal of Peritoneal-Irritation-Induced Ileus in Pierre J. M. Rivi#{232}re,Xavier Pascaud, 846 Rats: Possible Peripheral Action on Sensory Afferents Eric Chevalier and Jean-Louis Junien Downloaded from Role of Nitric Oxide-Dependent and -Independent Rachele Ciccocioppo, Luciano Onon, 929 Mechanisms in Peristalsis and Accommodation in the Rabbit Eliana Messon, Stefano M. Candura, Distal Colon Teresa COcCini and Marcello Tonini Acute Ethanol Inhibits Calcium Influxes Into Esophageal Ali Keshavarzian, Ossama Zorub, 1057 Smooth But Not Striated Muscle: A Possible Mechanism for Mohammed Sayeed, Glenn Urban, Ethanol-Induced Inhibition of Esophageal Contractility Chris Sweeney, Daniel Winship and Jeremy Fields jpet.aspetjournals.org Serotonin Inhibits Gastric Acid Secretion through a 5- Kathy J. LePard and 1139 Hydroxytryptamine1-llke Receptor in the Rat Robert L. Stephens, Jr. Nitric Oxide as a Mediator of Bisacodyl and Phenolphthalein Timothy S. Gaginella, Nicola Mascolo, 1239 Laxative Action: Induction of Nitric Oxide Synthase Angelo A. Izzo, Giuseppina Autore and Francesco Capasso

YM022 (R)-1-(2,3-dIhydro-l-(2’-methylphenacy1)-2-oxo-5- Akito NiShida, Yusuke Takinami, 1256 at ASPET Journals on October 6, 2021 phenyl-1H-1,4-benzodiazepin-3-ylj-3-(3-methylphenyl)urea}, a Hidenobu Yuki, Ayumi Kobasyashi, Potent and Selective Gastrin/Cholecystokinin-B Receptor Shinobu Akuzawa, TakeShi Kamato, Antagonist, Prevents Gastric and Duodenal Lesions in Rats Hiroyuki Ito, Mayumi Yamano, Yukinori Nagakura and Keiji Miyata Effect of Anisotonic Conditions on the Transport of Arthur B. J. Noach, Michinon Sakai, 1373 Hydrophilic Model Compounds Across Monolayers of Human Margret C. M. Blom-Roosemalen, Colonic Cell Lines Hugo R. de Jonge, Albertus G. de Boer and Douwe D. Breimer

IMMUNOPHARMACOLOGY A Mechanism of Action for Morphine-Induced David 0. Freier and Bruce A. Fuchs 1127 Immunosuppression: Corticosterone Mediates Morphine- Induced Suppression of Natural Killer Cell Activity Sore from Patients with Halothane Hepatitis Contain Trudy L. Knight, 1325 Antibodies to Halothane-Induced Liver Antigens Which Are Katherine M. Scatchard, Not Detectable by Immunoblotting Frank N. A. M. van Pelt and J. Gerald Kenna

NEUROPHARMACOLOGY Central Stimulation of Adrenocortical Secretion by David Saphier and Jon E. Welch 905 5-Hydroxyfryptamine1 Agonists is Mediated by Sympathomedullary Activation Central and Peripheral Mechanisms in the Stimulation of Jon E. Welch and David Saphier 918 Adrenocortical Secretion by the 5-Hydroxytryptamine2 Agonist, (±)-1-(2,5-Diinethoxy-4-Iodophenyl)-2- Aminopropane Differential Functional Activity of 5-Hydroxytryptamine Petrus J. Pauwels and Christiane Palmier 938 Receptor Ligands and Beta Adrenergic Receptor Antagonists at 5-Hydroxytryptamine18 Receptor Sites in Chinese Hamster Lung Fibroblasts and Opossum Renal Epithelial Cells

Contents continued on vi Conients continuedfrora v

Multiple Alpha2 Adrenergic Receptor Subtypes. I. A. Renouard, P. 5. Widdowson and 946 Comparison of 13H1RX821002-Labeled Rat M. J. Milan Adrenergic Receptors in Cerebral Cortex to Human Adrenergic Receptor and Other Populations of AlpIsa-2 Adrenergic Subtypes Multiple Alpha-2 Adrenergic Receptor Subtypes. II. Evidence M. J. Milan, K. Bervoets, J.-M. Rivet, 958 for a Role of Rat Adrenergic Receptors in the Control P. Widdowson, A. Renouard, of Nociception, Motor Behavior and Hippocampal Synthesis S. Le Marouille-Girardon and A. Gobert of Noradrenaline Studies on Species Sensitivity to the Doplaminergic Andrew Giovanni, Beth-Anne Sieber, 1000 Neurotoxin 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine. Richard E. Heikkila and Part 1: Systemic Administration Patricia K. Sonsalla Studies on Species Sensitivity to the Dopaminergic Andrew Giovanni, Patricia K. Sonsalla 1008 Neurotoxin 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine. and Richard E. Heikkila Part 2: Central Administration of 1-Methyl-4- Phenylpyridinium Endogenous Serotonin Stimulates Striatal Dopamine Release Gal Yadid, Karel Pacak, Irwin J. Kopin 1158 in Conscious Rats and David S. Goldstein Downloaded from Anticonvulsant Activity of Neurosteroids: Correlation with Tushar G. Kokate, Bj#{246}rnE.Svennson 1223 y-Amlnobutyric Acid-Evoked Chloride Current Potentiation and Michael A. Rogawski Imidazenil, a Partial Positive Allostenc Modulator of J. Auta, P. Giusti, A. Guidotti and 1262 GABAA, Receptors, Exhibits Low Tolerance and Dependence E. Costa Liabilities in the Rat jpet.aspetjournals.org Pharmacological Characterization of LY293284: A 5-HTA Mark M. Foreman, Ray W. Fuller, 1270 Receptor Agonist with High Potency and Selectivity Kurt Rasmussen, David L. Nelson, David 0. Calligaro, L. Zhang, James E. Barrett, Richard N. Booher, Charles J. Paget, Jr. and Michael E. Flaugh Single-Unit Repsonses of Serotonergic Dorsal Raphe Neurons Casimir A. Fornal, W. Joseph Litto, 1345 at ASPET Journals on October 6, 2021 to SHTIA Agonist and Antagonist Drug Administration in Christine W. Metzler, Franco Marrosu, Behaving Cats Koji Tada and Barry L. Jacobs

Effects of the Putative 5-HydroxytryptaminelA Antagonists Casimir A. Fornal, Franco Marrosu, 1359 BMY 7378, NAN 190 and (-)-Propranolol on Serotonergic Christine W. Metzler, Koji Tada and Dorsal Raphe Unit ActivIty in Behaving Cats Barry L. Jacobs Time Course of the Development of Behavioral Sensitization Ellen M. Unterwald, Ann Ho, 1387 and Dopamine Receptor Up-Regulation During Binge Cocaine Joshua M. Rubenfeld and Administration Mary Jeanne Kreek

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS Inhibitory Effects of n-6 and n-3 Hydroxy Fatty Acids on J. W. Karanian, H. Y. Kim and 1105 Thromboxane (U46619)-Induced Smooth Muscle Contraction Norman Salem, Jr. Antiaggregatory Activity of 8-Epi-Prostaglandin F, and Kingsley Yin, Perry V. Halushka, 1192 Other F-Series Prostanolds and Their Binding to Yu-Ting Yan and Patrick Y-K. Wong Thromboxane A/ProstagIandin H2 Receptors in Human Platelets , In Vii’o Glucocorticoids Regulate Cyclooxygenase-2 but not Jaime L. Masferrer, Sriivasa T. Reddy, 1340 Cyclooxygenase-1 in Peritoneal Macrophages Ben S. Zweifel, Karen Seibert, Philip Needleman, Rebecca S. Gilbert and Harvey R. Herschman

PULMONARY PHARMACOLOGY Selective Pulmonary and Venous Smooth Muscle Relaxation Stan Greenberg, Claude McGowan, 1077 by Furosemide: A Comparison with Morphine Jianming Xie and Warren R. Summer Release of Inflammatory Mediators from Guinea Pig Trachea Lynette B. Fernandes, 1166 by Electrical Field Stimulation: Lack of Neuronal Walter C. Hubbard and Involvement Bradley J. Undem Ro 25-1553: A Novel, Long-Acting Vasoactive Intestinal M. O’Donnell, R. J. Garippa, N. Rinaldi, 1282 Peptide Agonist. Part I: In Vitro and In Vivo Bronchodilator W. M. Seig, B. Simko, L. Renzetti, Studies S. A. Tannu, M. A. Wasserman, A. Welton and D. R. Bolin

Contents continued on vii Contents conzinuedfrom vi

Ro 25-1553: A Novel, Long-Acting Vasoactive Intestinal M. O’Donnell, R. J. Garippa, N. Rinaldi, 1289 Peptide Agomst. Part II: Effect on In Vitro and In Vii’o W. M. Seig, J. E. Tocker, S. A. Tannu, Models of Pulmonary Anaphylaxis M. A. Wasserman, A. Welton and D. R. Bolin Use of Selective Antagonists for Further Characterization of Xiang-Ping Zeng and Elizabeth Burcher 1295 Tachykinin NK-2, NK-1 and Possible “Septide-Selective” Receptors in Guinea Pig Bronchus

RENAL PHARMACOLOGY Bicarbonate-Dependent Amantadine Transport by Rat Renal Miguel R. Escobar, Leo T. Y. Wong and 979 COrtIcal Proximal and Distal Tubules Daniel S. Sitar , Endothelin ET Receptors Couple to Two Distinct Signaling Satoshi Ozaki, Masaki Ihara, 1035 Pathways in Porcine Kidney Epithelial LLC-PK1 Cells Toshihiko Saeki, Takehiro Fukami, Kiyofumi Ishikawa and Mitsuo Yano Telemetric Blood Pressure Monitoring in Benign 2-Kidney, Curtis K. Kost, Jr., Ping Li, 1063 1-Clip Renovascular Hypertension: Effect of Chronic Caffeine Cynthia A. Pfeifer and Edwin K. Jackson Ingestion

Dissimilar Alterations of Sodium-Coupled Uptake by Fran#{231}oiseCouijault-Gautier, 1097 Downloaded from Platinum-Coordination Complexes in Renal Proximal Tubular Delphine bet, Danielle Leroy and Cells In Primary Culture Herv#{233}J. Toutain Assessment of Ibuprofen-Associated Nephrotoxicity in Renal Ching-Yu (len, Victor Fei Pang and 1307 Dysfunction Ching-Shih Chen

TOXICOLOGY jpet.aspetjournals.org Effect of Selenium Deficiency and Glutathione-Modulating Joseph A. Awad, Raymond F. Burk and 858 Agents on Diquat Toxicity and Lipid Peroxidation in Rats L. J. Roberts, II Toxicity of Cephaloridine to Carnitine Transport and Fatty Bruce M. Tune and Chieh-Yin Hsu 873 Acid Metabolism in Rabbit Renal Cortical Mitochondria: Structure-Activity Relationships Lindane Increases Intracellular Calcium in Rat Myometrial Kay A. Criswell, Edward L. Stuenkel and 1015

Smooth Muscle Cells through Modulation of Inositol 1,4,5- Rita Loch-Caruso at ASPET Journals on October 6, 2021 Trisphosphate-Sensitive Stores

Erratum 1396 Erratum 1397 Index, Volume 270, July-September, 1994 1398

Table of Contents