The Journalof VOLUME27O PHARMACOLOGY SEPTEMBER 1994 AND EXPERIMENTAL THERAPEUTICS Contents ANALGESKS Differential Regulation of Mu and Delta Opiate Receptors by J. E. Zadina, L. M. Harrison, L.-J. Ge, 1086 Morphine, Selective Agonists and Antagonists and A. J. Kastin and S. L. Chang Differentiating Agents in SH-SYSY Human Neuroblastonia Cells Endogenous Opioids Released by Suspending Mice by the Forrest L. Smith, David A. Brase, 1177 Daniel Dombrowski and Tail Selectively Enhance Spinal Mu Opioid Analgesia S. William L. Dewey Downloaded from Genetic Analysis of Sensitization and Tolerance to Cocaine Bryan K. Tolliver, John K. Belknap, 1230 William E. Woods and John M. Carney Biochemical and Pharmacological Characterfration of Mu, Kelly M. Standifer, Jie Cheng, 1246 Delta and Kappa3 Opiold Receptors Expressed in BE(2)-C Andrew I. Brooks, Carlo P. Honrado, Neuroblastoma Cells Wendy Su, Luisa M. Visconti, June L. Biedler and Gavril W. Pasternak jpet.aspetjournals.org ‘-Tetrahydrocannabino1 Enhances the Secretion of Weigang Zhu, Catherine Newton, 1334 Interleukin 1 from Endotoxin-Stimulated Macrophages Yehia Daaka, Herman Friedman and Thomas W. Klein Molecular Mechanisms of Agonist-Induced Desensitization of Karen Raynor, Haeyoung Kong, 1381 the aoned Mouse Kappa Oploid Receptor John Hines, Guanghui Kong, Jeffrey Benovic, Kazuki Yasuda, Graeme I. Bell and Terry Reisine at ASPET Journals on October 6, 2021 AUTONOMIC PHARMACOLOGY The Endothelium of the Rat Renal Artery Plays an Pauline L. Martin and Alice Anne Potts 893 Obligatory Role in A2 Adenosine Receptor-Mediated Relaxation Induced by 5’-N-Ethylcarboxamidoadenosine and N’-Cyclopentyladenoslne Spinal Cholinergic Alpha-2 Adrenergic Interactions in Anand Lothe, Ping Li, Chuanyao Tong, 1301 Analgesia and Hemodynamic Centrol: Role of Muscarinic Young Yoon, Herv#{233}Bouaziz, Receptor Subtypes and NItrIC Oxide Dawn J. Detweiler and James C. Eisenach BEHAVIORAL PHARMACOLOGY Possible Involvement of the Activation of Voltage-Sensitive Kiyofumi Yamada, Shinobu Nakayama, 881 Calcium Channels in the Ameliorating Effects of Nefiracetam Tadashi Shiotani, Takaaki Hasegawa on ScopolamIne-Induced impairment of Performance in a and Toshitaka Nabeshima Passive Avoidance Task BehaviOral Effects of 6-Methylene Naltrexone (Nalinefene) in Charles P. France and Lisa R. Gerak 992 Rhesus Monkeys Behavioral Effects of the Systemically Active Delta Oploid S. Stevens Negus, Eduardo R. Butelman, 1025 Kwen-Jen Chang, Brian DeCosta, Agonist BW373U86 in Rhesus Monkeys Gail Winger and James H. Woods Pharmacological Characterization of the Novel Discriminative Philip Terry, Jeffrey M. Witkin and 1041 Stimulus Effects of a Low Dose of Cocaine Jonathan L. Katz Behavioral Effects of the Dopamine Autoreceptor Agonist Kimberly E. Vanover and 1049 PD 128483 Alone and in Combination with Cocaine William L. Woolverton Effects of Dopamine on Prolactin: Interactions with Cocaine Nancy K. Mello, Jack H. Mendelson, 1110 Self-Administration by Female Rhesus Monkeys John M. Drieze, Slew Koon Teoh, Maureen L. Kelly and J. Wallis Sholar Contents continued on iv Contents continued from iii CARDIOVASCULAR PHARMACOLOGY .- Inhibition of Nitric Oxide Synthase Prevents Myocardial J. Craig Hartman, Gary M. Kurc, 1071 Protection by Ramiprilat Thomas G. Hullinger, Theron M. Wall, Rita M. Sheehy and Ronald J. Shebuski Modulation of Renal Vasoconstrictor Effect of NGNifre-L All F. Hajj-ali, Thomas M. Reilly and 1152 Arginine in Rabbit by Angiotensin II and Alpha-i Adrenergic Pancras C. Wong Receptor Blockade Effect of Protein Kinase C on Cyclic 3’,5’-Adenosine Hon-Chi Lee, John J. Cal and 1171 Monophosphate-Dependent Phosphodiesterase in Hongwei Yu Hypertrophlc Cardiomyopathic Hamster Hearts p InhIbition of In Vii’o Myocardial Ischemic and Reperfusion Shawn C. Black, Charles S. Schasteen, 1208 Injury by a Synthetic Manganese-Based Superoxide Randy H. Weiss, Dennis P. Riley, Dismutase Mimetic Edward M. Driscoll and Benedict R. Lucchesi CELLULAR AND MOLECULAR PHARMACOLOGY Effects of KT-362, a New Antiarrhythmic Agent, on Yuan-Na Cheng, Tatsuto Kiyosue and 851 Membrane Ionic Currents of Guinea Pig Ventricular Makoto Arita Downloaded from Myocytes Endothelin Receptors: Binding and Phosphoinositide M. Breuiller-Fouch#{234}, V. H#{233}luy, 973 Breakdown in Human Myometrium T. Fournier and F. Ferr#{233} Potentiation of ‘y-Aminobutyric AcidA Receptor Cl- Current Sheryl A. Zimmerman, Mathew V. Jones 987 Correlates with In Vivo Anesthetic Potency and Neil L. Harrison Xanthlne Oxidase Inhibits Transmembrane Signal Donald E. Wesson and Stephen J. Effiott 1197 jpet.aspetjournals.org Transduction in Vascular Endothelial Cells KN-62, a Specific Ca/Calmodulin-Dependent Protein Katsuo Okazaki, Tomohiko Ishikawa, 1319 Kinase Inhibitor, Reversibly Depresses the Rate of Beating of Makoto Inui, Michihiko Tada, Cultured Fetal Mouse Cardiac Myocytes Kiyota Goshima, Tadashi Okamoto and Hiroyoshi Hidaka CHEMOTHERAPY at ASPET Journals on October 6, 2021 Pharmacokinetics and Bioavailability Study of Ethacrynic Frank P. LaCreta, James M. Brennan, 1186 Acid as a Modulator of Drug Resistance in Patients with Sherrie L. Nash, Robert L. Comis, Cancer Kenneth D. Tew and Peter J. O’Dwyer Interleukln-1j8-Mediated Metallothionein Induction and Yukihiro Kondo, Shiu-Ming Kuo and 1313 Cytoprotection Against Cadmium and cis- John S. Lazo Dlammlnedlchloroplatlnum DRUG METABOLISM AND DISPOSITION Metabolism of Vesnarinone by Activated Neutrophils: Jack P. Uetrecht, Nasir Zahid and 865 Implications for Vesnarinone-Induced Agranulocytosis Dennis Whitfield Ethinylestradlol Interacts with Liver Microsomes and Induces Leandro Fern#{225}ndez, Luis D. Boada, 1121 Octavio P. Luzardo, Manuel Zumbado, Binding Sites for Steroid Hormones in the Male Rat Liver Juan C. Dlaz-Chico, Bonifacio N. Dlaz-Chico and Ricardo Chirino Molybdate Depletes Hepatic 3-Phosphoadenosine 5- Takiko Oguro, Zolt#{225}nGregus, 1145 Phosphosulfate and Impairs the Sulfation of Acetaminophen Cherukury Madhu, Lan Liu and in Rats Curtis D. Klaassen The Pharniacodynamics and Pharmacokinetics of the James E. Caldwell, Janos Szenohradszky, 1216 Metabolite 3-Desacetylvecuronium (ORG 7268) and its Veronica Segredo, Peter M.C. Wright, Parent Compound, Vecuronium, in Human Volunteers Cormac McLoughlin, Manohar L. Sharina, Larry D. Gruenke, Dennis M. Fisher and Ronald D. Miller Selective Suppression of Rat Hepatic Cytochrome P450 2C11 James C. Kraner, Edward T. Morgan 1367 by Chioramphenicol and James R. Halpert Contents continued on v Contents continuedfrom iv ENDOCRINE PHARMACOLOGY Arginine Vasopressin-Stimulated Insulin Secretion and Ter-Hsin Chen, Bumsup Lee and 900 Elevation of Intracellular Ca Concentration in Rat Walter H. Hsu Insullnoma Cells: Influences of a Phospholipase C Inhibitor 1-(6417-methoxyestra-l,3,5(10)-trien-17-ylJaminoJhexyl}. 1H-pyrrole-2,5-dlone (U-73122) and a Phospholipase A2 Inhibitor N-(p-Amylclnnamoyl)anthranilic Acid Cocaine Effects on Pulsatile Secretion of ACTH in Men Siew Koon Teoh, Zoltan Sarnyai, 1134 Jack H. Mendelson, Nancy K. Mello, Sandra A. Springer, J. Wallis Sholar, Michel Wapler, John C. Kuehnle and Howard Gelles GASTROINTESTINAL PHARMACOLOGY Effects of Lovastatin in Humans on Biliary Lipid Composition William C. Duane 841 and Secretion as a Function of Dosage and Treatment Interval Fedotozine Reversal of Peritoneal-Irritation-Induced Ileus in Pierre J. M. Rivi#{232}re,Xavier Pascaud, 846 Rats: Possible Peripheral Action on Sensory Afferents Eric Chevalier and Jean-Louis Junien Downloaded from Role of Nitric Oxide-Dependent and -Independent Rachele Ciccocioppo, Luciano Onon, 929 Mechanisms in Peristalsis and Accommodation in the Rabbit Eliana Messon, Stefano M. Candura, Distal Colon Teresa COcCini and Marcello Tonini Acute Ethanol Inhibits Calcium Influxes Into Esophageal Ali Keshavarzian, Ossama Zorub, 1057 Smooth But Not Striated Muscle: A Possible Mechanism for Mohammed Sayeed, Glenn Urban, Ethanol-Induced Inhibition of Esophageal Contractility Chris Sweeney, Daniel Winship and Jeremy Fields jpet.aspetjournals.org Serotonin Inhibits Gastric Acid Secretion through a 5- Kathy J. LePard and 1139 Hydroxytryptamine1-llke Receptor in the Rat Robert L. Stephens, Jr. Nitric Oxide as a Mediator of Bisacodyl and Phenolphthalein Timothy S. Gaginella, Nicola Mascolo, 1239 Laxative Action: Induction of Nitric Oxide Synthase Angelo A. Izzo, Giuseppina Autore and Francesco Capasso YM022 (R)-1-(2,3-dIhydro-l-(2’-methylphenacy1)-2-oxo-5- Akito NiShida, Yusuke Takinami, 1256 at ASPET Journals on October 6, 2021 phenyl-1H-1,4-benzodiazepin-3-ylj-3-(3-methylphenyl)urea}, a Hidenobu Yuki, Ayumi Kobasyashi, Potent and Selective Gastrin/Cholecystokinin-B Receptor Shinobu Akuzawa, TakeShi Kamato, Antagonist, Prevents Gastric and Duodenal Lesions in Rats Hiroyuki Ito, Mayumi Yamano, Yukinori Nagakura and Keiji Miyata Effect of Anisotonic Conditions on the Transport of Arthur B. J. Noach, Michinon Sakai, 1373 Hydrophilic Model Compounds Across Monolayers of Human Margret C. M. Blom-Roosemalen, Colonic Cell Lines Hugo R. de Jonge, Albertus G. de Boer and Douwe D. Breimer IMMUNOPHARMACOLOGY A Mechanism of Action for Morphine-Induced David 0. Freier and Bruce A. Fuchs 1127 Immunosuppression: Corticosterone Mediates Morphine- Induced Suppression of Natural Killer Cell Activity Sore from Patients with Halothane Hepatitis Contain Trudy L. Knight, 1325 Antibodies to Halothane-Induced Liver Antigens Which Are Katherine M. Scatchard, Not Detectable by Immunoblotting Frank N. A. M. van Pelt and J. Gerald Kenna