How a Virus Circumvents Energy Barriers to Form Symmetric Shells Sanaz Panahandeh, Siyu Li, Laurent Marichal, Rafael Leite Rubim, Guillaume Tresset, Roya Zandi To cite this version: Sanaz Panahandeh, Siyu Li, Laurent Marichal, Rafael Leite Rubim, Guillaume Tresset, et al.. How a Virus Circumvents Energy Barriers to Form Symmetric Shells. ACS Nano, American Chemical Society, 2020, 14 (3), pp.3170-3180. 10.1021/acsnano.9b08354. hal-03035711 HAL Id: hal-03035711 https://hal.archives-ouvertes.fr/hal-03035711 Submitted on 4 Jan 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. How a virus circumvents energy barriers to form symmetric shells Sanaz Panahandeh,y Siyu Li,y Laurent Marichal,z Rafael Leite Rubim,z Guillaume Tresset,z and Roya Zandi∗,y yDepartment of Physics and Astronomy, University of California, Riverside, California 92521, USA zLaboratoire de Physique des Solides, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay Cedex, France E-mail:
[email protected] Abstract Previous self-assembly experiments on a model icosahedral plant virus have shown that, under physiological conditions, capsid proteins initially binds to the genome through an en masse mechanism and form nucleoprotein complexes in a disordered state, which raises the questions as to how virions are assembled into a highly or- dered structure in the host cell.