Lnternational Nonproprietary Names for Pharmaceutical Substances

WHO Drug Infomation, Vol.7, No.3, '1993

lnternational Nonproprietary Names for Pharmaceutical Substances g.n Notice is herebygiven that, in accordancewith paragraph 7of the Procedureforthe Selection of Becommended 'ed as lnternational N'oiproprietary Names for Pharinaceutical Substances', tho following !.amss- are selected nt and Recommended lriterhationil Nonproprietary Names. The inclusion of a name in the lists of Recommended enta- Internalional Nonproprietary Names'does hot inrply any recommendation of the use of the substance in t rnedicine or pharmacy. ts are Recommended International Nonproprietary Names (Rec. INN): List 33

proposed (1-65) recommended (1-31) internationalnonproprietary names can be found in of the Lists of and Cumulative List No. 8, 1992. rovide Recomm e nded I nte mati onal dpnical Name orDesiption aN Mol*ular Formula Nonprcprietary Name s, nor (l,attin, era Endish) }d alestramustinum estradiol 3-[bis(2-chloroethyl)carbamate], 17-ester with l-alanine alestramustine c26H36cl2N2o4 ora- Jby alglucerasum glucosylceramidase (human placenta isoenzyme protein moiety reduced) alglucerase C2$2H3ssaN5720711S16 f the (fo r non -g lycosylated protei n)

nal alovudinum 3'-deoxy-3'-f luorothymidine rr bulk alovudine c,oH13FN2O4 I nsw don altumomabum immunoglobulin G 1 (mouse monoclonal ZCEOzi anti-human antigen CEA), lt altumomab disuffide with mouse monoclonal ZCEOzslight chain, dimer iues amesergidum l*cyclohexyl- f -isopropylG-methylergoline-8p-cadroxamide c25H3sN3O :al amesergide s the amitivirum 1,3,4-thiadiazole-2-carbamonitrile amitivir caH2N4S

andolastum 4,4' -di- 1 t+letrazol-5-ylbenzanilide andolast c15H1'NeO

ardeparinum natricum Sodium salt of depolymerized heparin obtained by peroxide degradation (at ardeparin sodium elevated temperature) of heparhr from pork intestinal mucosa; the end chain slructure appears to be the same as the starting material with no unu€ual sugar residues piesent; the low molecular weight heparin produced difters from the starting material in molecular weight only; the average relative molecular mass range is 5,500 to 6,500 daltons, 98 per cent of which ranging qet*g9n 2'000 and t5,000; the degree of sullation is approximately 2,7 per disaccharidic unit.

' Olfrcial Records ot the Wodd Health OryanEation,1955, GO, 3 (Resolution EB15.F7); 1969, 173, '10 (Fesolution EB43.Re). t3s Recom men:ded I nte m at i onal Chemical Name ar Description and Molecular Formula Recommender Nonpropietary Name Nonprcprietaq (Latin, English) (Latin, English. artilidum (+)-a'-t(fl -a-(dibutylamino)- 1 -hydroxybutyllmethanesulfonanilide clinprostum artilide c1eH34N2O3s clinprost atrinositolum o-myoinositol 1,2,6-tris(dihydrogen phosphate) atrinositol C6H15015P3 deferipronum deferiprone avicaloninum 1-butyric acid-2-r--alanine-3-r--serine-7-(r-'2-aminobutyric acid)-26'L-aspartic acid- avicatonin 27 -t-u aline-29-r--alaninecalcitonin (salmon) dexniguldipinu c147H2€N41046 dexniguldipine

azasetronum (t)-6-chloro-3,4-dihydro-4-methyl-3'oxo-M3'quinuclidinyF2fl-1,4-benzoxazine'8- azasetron carboxamide dezinamidum c17H2oclN3o3 dezinamide

berefrinum m-l(2R,5R't-2-tert-butyl-3-methyl-5-oxazolidinyllphenol miritu.e with m-[(2S'5F)-2' dimiracelamun berefrine fert-butyl-3-methyl-S-oxazolidinyllphenol dimiracetam c14H21NO2 dozolamidum dorzolamide besigomsinum (+)-(6S,7S, biar-R1-',6,7,9-tetrahydro-1,2,3,1 3-tetramethoxy'6'7- besigomsin dimethylbenzo[3,4]cycloocta[1, 2- f ][ 1,3]benzodioxoF6'ol C2sH2sO7 drospirenonun drospirenone bizelesinum 1,3-bist2-tt(5r)-1-(chloromethyl)-1,6-dihydro'5-hydroxy-8'methylbenzo[1 ,2-h4'3' bizelesin d ldipynol-3(2F0-yllcarbonyllindol-5'yllurea c43H36cl2N8o5

camiglibosum duloxetinum camiglibose duloxetine

ecabapidum carsatrinum ecabapide carsatrin c25H26F2N6OS ecadotrilum ecadotril carzelesinum N-[2-[[(S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methyl= . carzelesin VenziS|t,z-a:,)q,s-dldipyriol-3(2fl)-yllcarbonyllindol'5-yll-6-(diethylamino)- (ester) 2-benzofurancarboxamide carbanilate enadolinum c41H37clN6o5 enadoline

cetelloxacinum (-)-7-l(2S,3R)-3-amino-2-methyFl -azetidinyll-1-(2,4'difluorophenyl)-6-fluoro-1,4- cetefloxacin dihydro-4-oxo-3-quinolinecarboxylic acid enazadremum c2oH16F3N3O3 enazadrem

cilansetronum (-)-(fl-5,6,9,10-tetrahydro-10-[(2-methylimidazol'1-yl)methyl]-4fFpyrido[3'2,1- enofelastum cilansetron lklcarbazol-l 1 (8H)-one enofelast c2oH21N3O

epoetinum alfe cladribinum 2-chloro-2'-deoxyadenosi ne epoetin alfa cladribine cloHr2clNso3

clinafloxacinum (+)-7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl'6-fluoro-1 ,4-dihydro- epoetinum bet clinafloxacin 4-oxo-3-quinol inecarboxylic acid epoetin beta c17H17clFN3o3

136 ,,

-jti'

B ecom mended I nte rn ati o nal Chemical Name or Description and Molecular Formula Nonproprietary Name (Latin, English)

clinprostum (+)-methyl (3aS,5RGF,6aS)-1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-[(E)-(3S)-3' clinprost hydroxy- 1 -octenyll-2-pentalenevalerate c22H36o4

deferipronum S-hydroxy- 1,2-dimethyl-4(1 l|-pyridone deferiprone cTHeNO2 partic acid- dexniguldipinum methyl 1,4-dihydro-2,6-dimethyl- dexniguldipine caoHssNsO6 zoxazine-8- dezinamidum 3-[(o,o,o-trif luoro-/rrtolyl)oxy]- 1 -azetidineca6oxam ide dezinamide C11H11F3N2O2 t-[(2S,5F)-2- dimiracetamum (t)-dihydro-1 l/-pynolo[1,2-a]imidazole-2,5(3H,6H)-dione dimiracetam c6H8N2O2

dorzolamidum (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4Ftthieno[2,3'b]thiopyran- dorzolamide 2-sullonamide 7,7-dioxide C1eH15N2OaS3

drospirenonum (6R7R 8R9S,10R,135,145,15S,165,17S)-1,3',4,6,6a,7,8,9,10'11'12'13,14,15,15a,16' hexadecahydro-1 0, 1 3-dimethylspiro- 11,2-b:4,3- drospirenone [17Fl-dicyclbpropa[6,7:15,16]cyclopentaIa]phenanthrene'17,2'(5'Fl){uranl- 3,5'(2f4-dione c24H3oo3

duloxetinum (+)-(S)-Mmethyl-y( 1 -naphthylory)-2-thiophenepropylamine duloxetine c,8H1eNOS

ecabapidum rn[[[(3,4-dimethoxyphenethyl)calbamoyl]methyllaminol-Mmethylbenzamide ecabapide czoH25N3O4

ecadotrilum M[(5]-(t-(mercaptomethyl)hydrooinnamoyllglycine, benzyl esler, acetate (ester) ecadotril c21H8NO4S

enadolinum Mmethyl-ISI(5 R7S,S S)-7-( 1 -pyrrolidinyl)- 1 -oxaspiro[4.5]dec'8-y[- - enadoline benzoluranacetamide c24H32N203 i-tluoro-1,4- enazadremum 4,6-dimethyl-2-[(6-phenylhexyl)amino]-5-pyrimidinol enazadrem ClsH2sNsO

enofelastum ( €)-4'-f luoro-3,5-dimethyl-4-stilbenol enofelast c16H1sFO

epoetinum alfa 1-165-erythropoietin (human clone X,HEPOFL 13 protein moiety)' glycoform o

epoelin alfa CsoeH 1 so1 N22eO2aoS5 (to r non -g lyasylated p rotei n)

epoetinum beta 1-165-erythropoietin (human clone IHEPOFL 13 protein moiety)' glycolorm B epoetin beta CsooHlsol N22eO2aoS5 (to r nong Iycosylated p rote i nl

137 R ecom mended I nte matio nal Chemical Name or Description and Molecular Formula Reammende Nonproprietary Name Nonpropietar. (Latin, English) (Latin, English

epoelinum gamma 1-16S-erythropoietin (human clone IHEPOFL 13 protein moiety), glycoform 1 icodulinum opoetin gamma CsoeH13ol N22eO21oSs icoduline (f or non-glycosyl ated p rote i n) idoxitenum idoxifene fialuridinum fialuridine igmesinum igmesine llezelastinum (t)-4-(pffuorobenzyl)-2-(hexahydro-1-phenethyl-'ll*azepin-4-yl)"1(21+)' llezelastine phthalazinone intoplicinum c2sH30FN30 intoplicine

furnidipinum (t)-methyl tetrahydrofurfuryl,l,4-dihydro-2,6-dimethyl'4'(onitrophenyl)' fumidipine 3,5-pyridinedicarboxylate iobitridolum c21H24N2O7 iobitridol

ganelromycinum An antibiotic produced by Streptomyces lydicus. iofratolum ganefromycin Ganefromycin is a complex antibiotic with two major components: a and p. iofratol

(2 8,4 8,6 q-7 -t(2 F",3F-,5 R.)-s-r-[(3E hexopyranosyl-( 1 a4)- G2,6-dideoxy-3- itasetronum itasetron

latanoprostun latanoprost component p (2E,4E,6E)-7-[(2R',3R.,5R.,-s-F-t(3E sE)-3-[[02,6-dideoxy-3-Omethyl-o-/yxo hexopyranosyl-('l+41-02,6-dideory-3-Gmethyl-p-nbohexopyranosyl-(1-'|4)'2,6- leminoprazolu dideoxy-3-@methyl-g-lta(ohexopyranosylloxyl-2-[(2S,39,4S',6F*)-telrahydro' leminoprazole

2,4,6-heptatrienoic acid, 24-phenylacetate levosimendan levosimendan

lifibrolum glemanserinum (t)- 1 -phenethyl-cr,-phenyl-4-piperidinemethanol lifibrol glemanserin c2oH25NO

linopirdinum grepafloxacinum (t)-1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyFT-(3-methyl-1-piperazinyl)-4-oxo-3- linopirdine grepafloxacin quinolinecarboxylic acid c1eH22FN3O3 lomerizinum lomerizine

gusperimus gusperimus losoxantronun losoxantrone

icatibantum mideplaninum icatibant mideplanin

icodextrinum dextrin, having more than 85"/o of its molecules with molecular masses between icodextrin 1640 and 45000 with a claimed-average molecular mass ol approximatively 20000 Ic6H12o6]n

138

: *::::3':,i:i''rr:?':lire'1 1r::r:'':r'::i';:i :'rir'3 :T.,:l1.1T- .''

,;; ;,t,;:#,.;:.-r*rr;r*"r,

Recom m ended I nte mational Chemical Name or Description and Molecular Formula Nonproprietary Name (Latin, English)

icodulinum 6-(2-thiazolylamino)-rncresol icoduline cloHr0N2OS

idoxifenum 1 -[2-[p( E-p-ethyl-c,-(piodophenyl)styryl]phenoxylethyllpyrrolidine idoxifene c28H3olNo

igmesinum (+)-cr-[(E)-cinnamyl]-M(cyclopropylmethyl)-cr,-ethyl-N-methylbenzylamine igmesine c23H2eN

intoplicinum 11 -[[3-(dimethylamino)propyl]aminol-8-methyl-7 f{benzofelpyrido[4'3-b]= intoplicine indol-3-ol c21H24N4O

iobitridolum N,N'-bis(2,3-dihydroxypropyl)-5-[2-(hydroxymethyl)hydracrylamido]'2,4'6-triiodo- iobitridol N, N'-dimethylisophthalamide c2oH28l3N3oe

iofratolum N,M'-(2-hydroxytrimethylene)bis[N'-[2-hydroxy-1-(hydroxymethyl)ethyl]'2'4'6- nd B. iofralol triiodo-5-[( S)-lactamido]isophthalamidel Cs1Hs5l5N6O13 >lhyl-a-lyxo 1 -carboxamide l-(144',)-2,6- itasetronum 2-oxo-M 1 oH,5cll-tropan-3cr-yl- 1 -benzimidazoline' -letrahydro- itasetron c16H20N4O2

3-hydroxy-2- latanoprostum isopropyl (A-7 -l(1 R,2 R,3 R,5 latanoprost fihyla-lyxo rl-(1+4)-2,6- leminoprazolum 'tetrahydro- leminoprazole 3-hydroxy-2- levosimendanum mesoxalonitrile (-)-tp l(B)-1,4,5,G-tetrahydro-4-methyF6-oxo-3' levosimendan pyridaz inyllphenyllhydrazone c14Hr2N6O

lifibrolum (x)- o]l4- @re r|butylphenyl)-2-hydroxybutoxylbenzoic acid lifibrol c2rH26o4

linopirdinum 1 -phenyl-3,3-bis(4-pyridylmethyl)'2-indolinone inyl)-4-oxo-3- linopirdine c26H21N3O

lomerizinum 1 -[bis(p-tluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine lomerizine c27H3oF2N2O3

losoxantronum 7 -hy drory -2-12-[(2-hydroryethyl)amino]ethyll -5'Il2'le' losoxantrone nydl'oryeinyt)aminolethyllaminolanlhra[1,9-cd] pyrazol'6(2H)-one c22H27N5O4

mideplaninum a mixture of six substances of which 70% is: mideplanin 1 S-amino-22,31 -dichloro- .w- -2,3,16,17,18,19,35

139 Recommende Recomm e nded I nte mation a I Chemical Name or Desciption and Molecular Formula Nonproprietary Name Nonpropiletaf (Latin, English) (Latin, English

prezatidi moexiprilatum (3S)-2-t(2S)-M[(1 S)-1-carboxy-3-phenylpropyl]alanyll-1 ,2,3,4-tetrahydro- cupri moexiprilat 6,7-dimethoxy-3-isoquinolinecarborylic acid prezatide copg c25H30N2O7

ramorelixum monatepilum (t)-I\r(6, 1 1 -dihydrodibenzofb,e]thiepin-1 1 -yl)-4-(pfluorophenyl)-1 - monatepil piperazinebutyramide ramorelix c28H30FN3OS namirotenum p[( E)-2-(5-isopropyF2-thienyl)propenyl]benzoic acid raxofelastum namirotene cl7Hlso2s raxofelast nasaruplasum prourokinase (enzyme-activating) (human clone pA3/pD2lpF1 protein moiety) remifentanilun nasaruplase c2o31 H31 N5s5o6or S3r 21 remitentanil

nerisopamum 1 -(paminophenyl)-7,8-dimethoxy-4-methyl5fF2,3-benzodiazepine nerisopam c1sH1eN3O2 revizinonum revizinone nexopamilum (25)-5-(hexylmethylamino)-2-isopropyF2-(3,4,5-trimethoxyphenyl)valeronitrile nexopamil c24H40N203 rifamexilum rifamexil niravolinum Mmethyl?-(mnitrophenyl)-M[(1 S,2S)-2-(1-pyrrolidinyl)-1 -indanyl]acetamide niravoline c22H25N3O3 olanzapinum 2-methyF4-(4-methyFl -piperazinyl)-10f/-thieno[2,3-b][1 ,5]benzoCiazepine olanzapine c17H2oN4S ritipenemum ritipenem orbifloxacinum 1-cyclopropyl-7-(cie3,5-dimethyl-1-piperazinyl)-5,6,8-trifluoro-1,4-dihydro-4-oxo-3- orbifloxacin quinolinecarborylic acid c1eH2oF3N3O3 safironilum safironil osateronum (+)-6-ch loro-'l 7-hydroxy-2-oxapregna-4,6-diene-3,20-dione osaterone c2oH25cl04 sanguinarii ch sanguinarium pegaldesleukinum 125-L-serine-2-133-interleukin 2 (human reduced), reaclion product with pegaldesleukin glutaric anhydride, esters with polyethylene glycol monomethyl ester saripidemum saripidem pendetidum N6-[Ar-[2-[[2-[bis(carborymethyl)amino]ethyll(carboxymethyl)aminolethyll- pendetide M(carborymethyl)glycyll- N'?-( Mglycyl-r--tyrosyl)-r--lysine ca1H47N7O14 satigrelum satigrel pidobenzonum S-oxo-r--proline, p-hydroryphenyl ester pidobenzone c11H11NO4 satumomabun satumomab polidroninii chloridum polidronium chloride sebriplatinum sebriplatin pranlukastum t$[4-oxo-2-(1 FFtetrazol-5-yl)-4F-1-benzopyran-8-yl]-p(4-phenylbutoxy)= pranlukast benzamide semorphonun c27H23N504 semorphone

140 ::,;;;tr:ia'@;.r+t *l;*;:t&i;6*L;;t;,li'+it ,',*'',-.::;'i!:l; :.1:

B ecomme n ded I ntem ati o nal Chemical Name or Description and Molecular Formula Nonproprietary Name (Latin, English)

prezatidi cuprici acetas hydrogen IN2-(N-glycyl-r-histidyl)-r-{ysinato][N2-(N-glycyl-r--histidyl)- prezatide copper acetate r{ysinato(2-)lcuprate(1 -), diacetate C2sHa6CuN12O I . 2 CzH 4O2

ramorelixum 1-[Macetyl-3-(2-naphthyl)-o-alanyFpchloro-o-phenylalanyl-o-tryptophyl-L'seryl-L- ramorelix tyrosyl- O(6-deoxy-o-L-mannopyranosyl)-o-seryl-l-leucyl-l-arginyl't-- prolyllsemicarbazide c74Hs5clN1601s

raxofelastum (1)-2,3-dihydro-5-hydroxy-4,6,7-trimethyl-2-benzofuranacetic acid, acelate raxofelast C15H1gO5

remilentanilum 4-carboxy-4-(Mphenylpropionamido)1 -piperidinepropionic acid, dimethyl remifentanil ester c20H2sNzos

revizinonum (Q-N-cyclohexyl-Mmethyl-2-[[[d-(1,2,3,5-tetrahydro-2-oxoimidazol2,l-bl= revizinone quinazolin-7-yl)benzylidenelaminolorylacetamide c26H2eN503

rifamexilum (9S,1 2E, 1 45,1 5B 1 6S, 1 7F,1 8R 19 R,205,21 5,22E,244-2-(diethylamino)- rifamexil 5,6,16,18,20-pentahydroxy-'14-methoxy-7,9,15,17,19,21,25'heptamethyl' 9,4-(epoxypentadeca[1,11,13]trienimino)furo[2',3':7,8]naphtho[1,2-d]thiazole- 1 0,26(9Ft)-dione, 1 G-acetate c42Hs5N3O11S

ritipenemum -7-oxo-4-thia-1-aza= ritipenem dro-4-oxo-3-

safironilum N, N'-bis(3-methoxypropyl)-2,4-pyridinedicarboxamide safironil C15H2sN3Oa

sanguinarii chloridum sanguinarine chloride or 13-methyl[1 ,3]benzodioxolo[5,6-c]-1 ,3'dioxolo[4,5-i]= sanguinarium chloride phenanthridinium chloride c2oH14clNo4

saripidemum N-[[2-(pchlorophenyl)imidazo[1,2-a]pyridin-3-yllmethyll'N-methylbutyramide saripidem cleH2oclN3o

satigrelum 4-cyano-5,5-bis(pmethoxyphenyl)-4-pentenoic acid satigrel c2oH1eNO4

salumomabum immunoglobulin G 1 (mouse monoclonal 872.3 anti-human glycoprotein satumomab TAG-72'), disulfide with mouse monoclonal 872.3 light chain, dimer

sebriplatinum (+)-cle(1,1-cyclobutanedicarboxylato)[(2F)-2-methyl-1,4-butanediamine- sebriplatin N,N'lplatinum clrH2oN2O4Pt

semorphonum (-)-4,5o-epoxy-3, 1 4-dihydroxy- 1 7-(2-methoxyethyl)morphinan-6-one semorphone c1eH23NO5 Recommende' R ecom m e nd ed I ntern atio n al Chemical Name or Description and Molecular Formula Nonproprtehry Name Nonproprieta4 (Latin, English) (Latin, English

sepimoslatum 6-amidino-2-naphthyl p(2-imidazolin-2-ylamino)benzoate turosteridum sepimostat c2lHreNso2 turosteride

siratiazemum (+)-(2S,3S)-2,3-dihydro-3-hydroxy-5-[2-(isopropylmethylamino)ethy|]-2-(P valsartanum siratiazem methoxyphenyl)- 1,5-benzothiazepin-4(5H)-one acetate (ester) valsartan c24H30N2O4S venritidinum venritidine sonerminum 3- 1 s7-tumor necrosis factor (human) sonermin c767H12o4N21oo22eS2

zamifenacinun (5F,6S)-6-t(1 B)-1 -hydroryethyll-7-oxo-3-[[(3S)-tetrahydro-3-thienyl]thiol-4-thia-1' sulopenemum zamifenacin sulopenem azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (F)-9oxide cl2H15NO5S3 zanoteronum zanoterone tallimustinum N"- (2-amidinoethl)-a-[p-[bis(2-chloroethyl)amino]benzamidol-1 ,1 ',1"-trimethyl' tallimustine M4': tf ,4"terfpyrrole-2-carboxamide] cazH38cl2N1oo4

tarazepidum (-)-M(S)-2,3-dihydro-1-methyF2-oxo-S-phenyl-1F/-1 ,4-benzodiazepin-3-yll'5,6- tarazepide dihydro-4FI-pyrrolo[3,2, 1 -l ]quinoline-2-carboxamide C2sH2aNaO2

teloxantronum teloxantrone

tetrazolastum 4-( 1 FFtetrazol-s-yl)tetrazolo[1,5-a]quinoline tetrazolast ClsH6Ng

thymoctonanum MlMlN'z-[1-[MIM(/Sr--leucyl-r--a-glutamyl)-r-

tiotropii bromidum 6p, 7p-epoxy-3p-hydrory-8-methyl- 1 cfl,5crf/-tropanium bromide, liotropium bromide di-2-thienylglycolate CleH22BrNOaS2

tiquesidum (25F)-5o-spirostan-3p-yl 4- Gp-o-glucopyranosyl-p-o-glucopyranoside tiqueside caeH64o13

tirapazaminum 3-amino-1,2,4-benzotriazine 1,4-dioxide tirapazamine c7H6N4O2

trefentanilum N-[1-[2-(4-ethyl-5-oxo-^z-tetrazolin-1-yl)ethyl]-4-phenyl-4-piperidyll- trefentanil 2'{luoropropionanilide c25H31FN6O2

tripalmitinum tripalmitin or 1,2,3-propanetriyl trihexadecanoate tripalmitin c51Heso6

troglitazonum (!\,-all-rac5-lp-[(6-hydroxy-2,5,7,8tetramethyF2-chromanyl)methoxy]benzyll-2,4- troglitazone thiazolidinedione c24H27N05S

142

.u4 e€l*..e r ;:, ::;.. ir:, Recommended lnternational Chemical Name or Description and Molecular Formula a, Nonproprietary Name ,:r (Latin, English) 'r'., turosteridum 1,3-diisopropyl- 1 -[(4-methyl-3-oxo-4-aza-5s-androstan- 1 7p-yl)carbonyl]u rea ..i: turosteride c27H45N3O3

,. valsartanum N-[p(o 1 FFietrazol-S-ylphenyl)benzyl]-N-valeryl-r-valine .: valsartan c24H2eN5O3

l venritidinum (J)-(4-Mmethyl-2-nitro-N'-[2-[[5-[(tricyclo[2.2.1.02'6]hept-3-ylamino)= venritidine methyllturfurylllhiolethyll-1, 1 -ethenediamine c18H26N4O3S

i zamilenacinum (F4-3-(diphenylmethoxy)- 1 -[3,4-(methylenediory)phenetyl]piperidene zamifenacin c27H2eNO3

.l::i zanoteronum 1'-(methyf sulfonyf )-1'tF5a, 1 7cr-pregn-20-yno[ 3,2' clpyrazollT'ol zanoterone c23H32N203S AMENDMENTS TO PREVIOUS LISTS

Chronicle of the World Health Organization, Vol. 9, 1955

Recommended Internatlonal Nonproprietary Names (Rec. INN): List 1 p. 187 delete insert corticotrophinum corticotropinum corticotrophin corticotropin

Supplement to WHO Chronicle Vol. 33, No. 10, 1979

Recommended International Nonproprietary Namee (Rec. INN): List 19 p. 6 pipecuronii bromidum replace the chemical name by the falowing: pipecuronium bromide {,4'-(3a-17p-dihydrory-5c-androstan-2F,1 6p-ylene)bis[1 ,1 -dimethylpiperazinium] dibromide, diacetate (ester) C35H62Br2NaOa

Supplement to WHO Chronicle Vol. 38, No. 6, 1984

Recommended International Nonproprietary Names (Rec. INN): List 24 p.5 icospiramidum replace the chemical name by the following: icospiramide 8-[cle4-cyano-4-(pfluorophenyl)cycloheryl]-1-(pfluorophenyl)-4-oxo-1,3,8- triazaspiro[4. 5]decane-3-acetamide

Supplement to WHO Chronicle Vol. 40, No. 6, 1986 Recommended International Nonproprietary Names (Ree.INN): List 26 p.2 bropiriminum replace the chemical name by the following: bropirimine 2-amino-5-bromo-6-phenyl-4(3f/)-pyrimidinone

WHO Drug Information, Vol. 1, No.4, 1987 Recommended International Nonproprietary Names (Rec. INN): List 27 p.5 fosinoprilum replace the chemical name by the following: fosinopril (4Q-4-cyclohexyF 1 -KA-t( 5)- 1 -hydrory-2-methylpropoxyl(4-phenylbutyl)= phosphinyllacetyll-r--proline propionate (ester)

WHO Drug Information, Vol.5, No. 3, 1991

Recommended International Nonproprietary Names (Rec. INN): List 31 p.7 leuciglumerum replace the molecular lormula by the following: leuciglumer (C6H13NO2 . C6H11NO4)n

WHO Drug Information, Vol.6, No.3, 1992 Recommended International Nonproprietary Names (Rec. INN): List 32 p.3 dexfosfoserinum replace the chemical name by the following: dexfosfoserine (+)-r--serine dihydrogen phosphate (ester)