DOCSLIB.ORG

United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypothesis United Nations Censors Dr

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypothesis United Nations Censors Dr ,Þ United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypotlresis - Medical Ve... Page I o129 'IItt¡ q IT¡ Home ) United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypothesis United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypothesis 0 i 0 0 New 0 0 0 Like G+l EXH,lrglT C-57 http://medicalveritas.org/united-nations-censors.dr-leonard-horowitzs-origin-of-aids-thesis/ 212512017 United Nations Censors Dr. Leonard Horowitz's Origin of AIDS F{ypothesis - Medical Ve... page 2 of 29 UN To Censor Dr. Leo,nard G. Horowitz's "Manmade" Origin of AiDS Research? March 4,2008 Open Appeal by the Author, Dr. Horowitz 9_. I was recently alerted that United Nations sponsored AIDS groupr, . hosted by the UN AIDS Secretariat to the UN Theme Group on AIDS, is considering censoring my research determ¡nat¡ons and publications, along with Internet links to vaccination theories on the origin of HIV/AIDS. suppressing Internet free speech is troubling, but censoring scientific facts concerning AIDS and its apparent man-madè, vaccine-linked, origin is despicable and genocidal. theory,'explains the trrgber¡ng of thþ :' AIQS pandemic in the late 1970s and earl¡r BOs ¡n itlLse ðpecific par:ts of the'wórld; ": .,,] . ,i'' Please kindly read and forward this information as widely as possible so that we rh,ay shed the light of truth into the dark deceptions of ', vaccine industrialists contrdlli¡1g mqdical and ì'.p-uþlic healtht' pr:ostjtufes undermining the''legitimacy, integr:ity, and credi'bility of health' '.:;, sciehcei'' , '.';ì,,, ", ' .t., .', ,'. ¡,;; .- , l. .'ia:.. i. ì : | '" ,:.' :.' ":' http://medicalveritas.orglunited-nations-censors-dr-leonard-horowitzs-o:igin-of-aids.thesis/ 2/25120I7 United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypothêsis - Medical Ve... Page 3 of 29 In add,i'tion, if you have not viêwed my latest docuÌnentary f¡lm, In Lies We Trust: The,CtrA, Hollywood & Bioterrorism, available now online fo'r freê viewing,without copyright restrictions, please do so at your earliest convenience at www.inlieswetrust.com. Thank you for your educational outreach and activism. Together we shall overcome ign'orance and adversity in co*creating a healthy world In the Spirit of health and'human service. l-eonard G. Horowitz, D.M.D., M.4., M.P.H.,'D.N.M., D.M.M.Overseer and Manag¡ng MemberHealthy World Distributing, LLC Lette,r to th,e trnternational AIDS COMMUN,ITY (a.ids- se@sol ution.excha nge-u n, net. i n ) : The sun is claimed to cure infantile'jau,n;dice.;But in Anlerica, if you claim your use of a similar spectrum of light frequencies produced by an Ott,,La:mp cures thisrand rnoreì,'you are'cha'rged'with a c,rime-: ;, sent to,court'; maybe to,jailr,beca'u'se,I-IG;HT.,is,,legally , ,' : misrepresented as a *DRUG" if you simply'state'this:claim in'the med ia. Is this scientific? Is this ,even reasonabl,e? I's th:ere any evidence that LIGHT is a DRUG? The Moderator of.AIDS COMMUNITY dernonstrates similar blind bias, and grossly disservi,ces,the AIDS,COMMUNITY by his condescendinE rhetorical remark degrading this author:who has better things to do with his time and life than serve those "without ears to hear, nor eyes to see" the truth that could set the world free from infectious d iseases. I provided for the AIDS COMMUNITY's evaluation of scientific material the facts that were published in the UK in Journal of Medical Hypothesrs. (See attachment below.) That scientific peer reviewed article is damning enough for any reputable HIV/AIDS investigator to be persuaded to investigate further and stimulate debate. http://medicalveritas.org/united-nations-censors-dr-leonard-horowitzs-origin-of-aids-thesis/ 2125/2017 United Nations Censors Dr. L.eonard Horowitz's Origin of AIDS Hypothssis - Medical Ve.,.. page 4 of 29 Apparently,,Dr. Moderator, who encourages censorship, has less intelligence and professional integrity th.an,a comrngn fool. Every physician knows that diag'nosis precedes treatrnent, âfld that,the diagnostic process involves a differential diagnosis. Here we are THEORIZING what ails the patient-civilization. Here, as the, late great AIDS Czar,for the World H,ea,lth Organ,ization, Jonathan Mann, said, "Rather than a medical problem, AIDS is a , socio-political IMPOSITION." His statement heralds a critical component in'the differ:ent¡al diag,nosis of this hideous pandemic; one that,Th,e Mod'erator wishes to'stiike from,t,he record while assailing its proponents. Diagnosis means "to see,throug,hl'to the;r:oot.cau,se of the disord,en. With blind bias, you can't see through anything;,including,the r:oot of this disorder called AIDS; as well evidenced by The Moderator's wr,itten statemerit,reflecting,such; blind,bias. ' i \ : ': .' ..,. ,. ' I Censorslnip is totall'y ,u,nscientifia;,trnreasonable;,iries,ponsibl,e, a'nd undermining as ilrbreaches profe,sslona,l'aridisclenti,fic integrity , ,t : beyond the Atr'DS Comm.unityr. Efforts to effectively diagnose and treat this world's worst cancer cornplex,âre thre,atened'to' sto:pr here at th,e tJnited Natio,ns. ,For.all we know, IF my scientific thesis is accurate as the com;pelling evidence supporting it has proven to be by peer-reviewed scientific s,Crutiny,'THEN t'he origin of. AIDS' th"r:oug,h,ôontami:nated vaccin¿itións; specifically the hepatitis B'vaccine p,¡e¿'uced initially in chimpanzees and rhesus'rnonkeys b'etWeen I,97'A.a:nd 7974, not the polio vaccine of the 1950s and'1ater; MIGI.IT STILL BE FUELING THE AIDS PANDEMIC! Only a grossly-malfeasant blindly-biased sociopath would neglect this proba bility. Perhaps it's time to appoint,ä new Moderator for the AIDS community at the United N,atio,ns http://medicalveritas.org/united-nations-censors-dr-leonard-hor.owitzs.origin,of-aids-thesis/ Z/25l20I7 United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypothesis - Medical Ve... Page 5 of 29 http ://www. orig i nofa ids. com/a rticles / polio. htm Pol io, Hepatitis B a nd AIDS:An Integrat¡ve Theory on a Possible Vaccine Induced Pandemic tsy Leonard G.,Horowitz, D.M.D., M.4., M.P.H. Folio, Hepatitis B and AIDS: An lntegrative Theory on a Possible Vaccine lnduced Pandemic By Leona rd G. Horowitz, D.M.D., M.4., M.P.H http : //www. tetra hed ro n.org / E-mail : tetra @tetrahedron. org The following paper was accepted fol publication in the Journal of Medical Hypoth"eses:tThe firral edíted manuscript was published ttlläyrZ0û1, Vol. 56,'No. ;po :'553.-6$4. 'éxist'between 'this paþêr and'tne 'iìnal 5;" 'St'igrrt- 'differeäCes r: r: publication. ', 'l Editor:in-Chief:' Dr. David F. Horrobin, Laxdale Limited Kings Park House, Laurelhill Business Park, Stirling FK7 gJQ, UK Abstract The hypothesis that simian virus 40 (SV40) infected polio vaccines may be linked to the evolution of acquired immunodeficiency disorder (AIDS), and certain cancers, has been advanced. Most recently, investigators discussed the likelihood of "gene-reshuffling" following SV40 infection as a precursor to acquired immune dysfunction. Findings of recent SV40 infections in four children born after 1982 suggest infections were transmitted vertically along gene lines. Earlier observations proved activation of a retrovirus gene by a hepatitis B virus (HBV) protein. This paper proposes a new integrative theory http://medicalveritas.orglunited-nations-censors-dr-leonard-horowitzs-origin-of-aids-thesis/ 212512017 United Nations Censors Dr. Leonard Horowitz's Origin of AIDS Hypothesis - Medical Ve.., page 6 of 29 on the origin of AlDS,..,lt advances the possi,bility of genetic recomþinations with oncogene actjvation by HBV involving SV40, chimpanzee immungdeficiency virus (SlVcpz), and other simian viruses containing reverse transcriptase, that likely infected polio vaccinated blood donors to the initial hepatitis B (HB) vaccine trails conducted on gay men in New York City and other minority groups including Blacks in Uganda in the early to mid-'l970s. lntroduction and Background Scientific reporls have advaneed a theory of a polio vaccine linked evolution of AIDS and certain cancers. (1-4) A possible link between SV40, that contaminated earl,y Salk 'and Sabin polio vacçines; and AIDS, was initially explored by Kyle in The Lancet in 1992.(4) lnvestigators Urnovitz(1), Butel(2-3) and others(4), discussed the likelihood of "gene-reshuffling"'following SV40 infection as a precursor to acquired imrnune dysfunction and the development of certain cancers. Likewise, Butel revealed evidence o-f recent SV40 infections in four children born after 1982.(3) Her team aduan"ed'the likelihood that the infections were transmitted vertically, along gÇne lines, from parents who had received tainted polio vaccines. Earlier, she observed the activation of a HTLV-1 retrovirus gene by a HB virus protein.(5) With an acknowledged thrqat of SV4O recombination in assoçiaiion wittr lmrnune suppression, ?ld possible onçogene devqlo'pment or activation in polio vaccine and possibly HB vaccine recipients and'tñeir offspring, this paper advances an integrative theory on the origin of AIDS. lt asserts the possibility of genetic recombinations between SV40, chimpanzee immunodeficiency virus (SlVcpz), and/or other simian viruses containing reverse t¡anscriptgse such as the foamy retroviruses (SFR), that likely infected blood donors who had first received contaminated polio vaccines in the 1950s and early :lg60s, before volunteering for the HB vaccine trails conducted on gay men in New York City (NYC), Blacks in central Africa, and other minority groups in 1974 through 1975. Ten :years later,, in 1984, the Centers for Disease Control and Prevention (CDC) first responded to concerns that experimental HB vaccines, administered durirng the 1970s to homosexual men in the United States, were somehow linked to the AIDS epidemic.(6) Anonymous authors representing the CDC, along with others from Merck, Sharp & Dohme (MSD), aná the State University of New York (SUNY), reported no trace of the human immunodeficiency virus (HlV-1) in samples of vaccine supplied by MSD Further, their epiderniologic analyses, conducted on gay HB vaccine trial http://medicalveritas.orglunited-nations-censors-d¡-leonard-horowitzs.origin-of-aids-thesis/ 2/2512017 United Nations Censors Dr.
Load more

Recommended publications
  • QA& Raabya Rossenkhan Kathleen Wirth
    H A I spotlisummer g ht 2015 HARVARD T.H. CHAN SCHOOL OF PUBLIC HEALTH AIDS INITIATIVE THE YOUNG INVESTIGATORS ISSUE Raabya Rossenkhan The Will to Make It Work Raabya Rossenkhan was always interested in science, so majoring in biology at the University of Botswana (UB) was an obvious choice. When she was offered a scholarship to continue her education, she saw the need to study HIV/AIDS. The year was 2003. In Botswana, the HIV prevalence among pregnant women was almost 40%. Kathleen Wirth “A lot of people were dying at the time. I Max had friends whose parents were dying. There In Search of the Purposeful was a lot of stigma associated with HIV. You Essex would hear stories, but nobody ever directly Growing up, Kathleen Wirth knew she wanted Q spoke about it,” said Raabya. She wanted to & to see the world outside of her small hometown A help end the crisis that was devastating her of Irmo, South Carolina. She felt she didn’t country. quite fit in. Her mother’s family had fled The Importance of Being from Cuba in 1960. Her grandfather, who’d There was just one problem. When Raabya and Having a Mentor been a respected doctor in Havana, worked indicated that she wanted to conduct HIV/ as a hospital janitor until he could qualify AIDS research, the UB Biological Sciences Max Essex is the Lasker Professor to practice medicine in America. Though Department said it would be difficult. For of Health Sciences at Harvard she got into minor trouble, it wasn’t enough the Master’s programs, there was either a food University and the Chair of the to keep Kathleen from becoming her high (continues on page 2) Harvard AIDS Initiative and the school valedictorian.
    [Show full text]
  • 2Nd International Conference on Flu October 31-November 02, 2016 San Francisco, USA
    Donald P Francis, Virol Mycol 2016, 5:3(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2161-0517.C1.013 2nd International Conference on Flu October 31-November 02, 2016 San Francisco, USA Donald P Francis Global Solutions for Infectious Diseases, USA WHO technology transfer activities for influenza vaccines he World Health Organization states that, “Though the world is better prepared for the next pandemic than ever before, Tit remains highly vulnerable, especially to a pandemic that causes severe disease. Nothing about influenza is predictable, including where the next pandemic might emerge and which virus might be responsible.” WHO’s preparations to minimize the impact of influenza virus related disease cover a wide variety of activities that include surveillance of circulating viruses (in both birds and humans), supplying current circulating virus reagents for clinical diagnosis of cases, efforts to expand influenza vaccine production in lower and middle income countries and collaboration and support of trials to evaluate vaccines in people. The surveillance efforts are essential to identifying circulating viruses so subsequent control activities can be matched to the strain and clinical severity of the disease. In 2014, 142 laboratories in 112 countries joined together in what is known as the Global Influenza Surveillance and Response System. The laboratories in that system tested more than 1.9 million clinical specimens. To speed the diagnostic capabilities for this rapidly changing infection, WHO supplies reagents capable of identifying the latest circulating viruses; for example for the 2009 when the H1N1 outbreak was declared a public health emergency, WHO shipped out diagnostic reagents to laboratories within seven days.
    [Show full text]
  • The Transnational Legal Process of Global Health Jurisprudence: HIV and the Law in Indonesia
    The Transnational Legal Process of Global Health Jurisprudence: HIV and the Law in Indonesia Siradj Okta A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Washington 2020 Reading Committee: Walter J. Walsh, Chair Rachel A. Cichowski Dongsheng Zang Aaron Katz Program Authorized to Offer Degree: Law © Copyright 2020 Siradj Okta University of Washington Abstract The Transnational Legal Process of Global Health Jurisprudence: HIV and the Law in Indonesia Siradj Okta Chair of the Supervisory Committee: Walter J. Walsh School of Law As one of the most pressing global health priorities, HIV disruption requires effective transnational work. There is growing confidence among experts about ending AIDS by 2030. In Indonesia, a country with one of Asia’s fastest-growing HIV epidemics, the law is instrumental to achieve that goal. Nonetheless, national laws and policies that undermine HIV prevention are continuously being adopted or preserved. This suggests that the presence of global health jurisprudence does not necessarily lead to national legal processes to enable HIV prevention policies. This situation raises the central question of whether the perpetuation of national legal barriers to HIV prevention is associated with Indonesia’s internalization of global health jurisprudence. This study uses Professor Harold Koh’s transnational legal process theory to examine the transfer of global health jurisprudence by looking at Indonesia’s interaction at the global level, interpretation of norms, and domestic internalization thereof. As a multi-method study with an inductive reasoning approach, this research utilizes a qualitative data analysis of international organizations’ laws and policies, public/private institutions’ policies, international treaties, Indonesian laws, and relevant public records.
    [Show full text]
  • Rates and Patterns of Indels in HIV-1 Gp120 Within and Among Hosts
    Western University Scholarship@Western Electronic Thesis and Dissertation Repository 8-19-2020 1:00 PM Rates and patterns of indels in HIV-1 gp120 within and among hosts John Lawrence Palmer, The University of Western Ontario Supervisor: Poon, Art F.Y., The University of Western Ontario A thesis submitted in partial fulfillment of the equirr ements for the Master of Science degree in Pathology and Laboratory Medicine © John Lawrence Palmer 2020 Follow this and additional works at: https://ir.lib.uwo.ca/etd Part of the Molecular Genetics Commons Recommended Citation Palmer, John Lawrence, "Rates and patterns of indels in HIV-1 gp120 within and among hosts" (2020). Electronic Thesis and Dissertation Repository. 7308. https://ir.lib.uwo.ca/etd/7308 This Dissertation/Thesis is brought to you for free and open access by Scholarship@Western. It has been accepted for inclusion in Electronic Thesis and Dissertation Repository by an authorized administrator of Scholarship@Western. For more information, please contact [email protected]. Abstract Insertions and deletions (indels) in the HIV-1 gp120 variable loops modulate sensitivity to neutralizing antibodies and are therefore implicated in HIV-1 immune escape. However, the rates and characteristics of variable loop indels have not been investigated within hosts. Here, I report a within-host phylogenetic analysis of gp120 variable loop indels, with mentions to my preceding study on these indels among hosts. We processed longitudinally-sampled gp120 sequences collected from a public database (n = 11,265) and the Novitsky Lab (n=2,541). I generated time-scaled within-host phylogenies using BEAST, extracted indels by reconstructing ancestral sequences in Historian, and esti- mated variable loop indel rates by applying a Poisson-based model to indel counts and time data.
    [Show full text]
  • Annual Report
    Extending the Frontiers of Science and Health: Research, Care, and Prevention in Action 2010 ANNUAL REPORT Wei Huang, PhD, Assistant Professor, Division of Basic Science and Vaccine Development, Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine 2 CONTENTS Director’s Message....................................................... 5&7 Our Mission .......................................................................9 IHV Leadership ................................................................10 About IHV ........................................................................11 Division of Basic Science and Vaccine Development ......13 Division of Clinical Care and Research ...........................18 Division of Epidemiology and Prevention ......................22 Financials and Related Charts .........................................26 IHV Board Memberships .................................................27 Photo above: Maria Salvato, PhD, Professor, Division of Basic Science and Vaccine Development, Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine and Igor Lukashevich, MD, PhD, Associate Professor, Division of Basic Science and Vaccine Development, Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine 3 4 DIRECtor’S MESSAGE The Institute of Human Virology (IHV) at the University of Maryland School of Medicine had a prosperous and eventful year in FY10. In the Basic Science and Vaccine Development Division led by Dr. George Lewis and me, IHV’s preventative HIV vaccine candidate research continued to make progress with our colleague Dr. Tony DeVico through funding by the Bill and Melinda Gates Foundation and the National Institutes of Health. The next phase of funding would include researching the vaccine candidate through clinical trials next year. Also in the BSVD Division, IHV researchers including Dr. David Pauza continued to study the rise of HIV-related cancers as a growing Robert C.
    [Show full text]
  • Human Retroviruses in the Second Decade: a Personal Perspective
    © 1995 Nature Publishing Group http://www.nature.com/naturemedicine • REVIEW Human retroviruses in the second decade: A personal perspective Human retroviruses have developed novel strategies for their propagation and survival. A consequence of their success has been the induction of an extraordinarily diverse set of human dlst!ases, including AIDS, cancers and neurological and Inflammatory disorders. Early research focused on their characterization, linkage to these dlst!ases, and the mechanisms Involved. Research should now aim at the eradication of human retroviruses and on treatment of infected people. Retroviruses are transmitted either geneti- .................... ···.. .... ·. ..... .. discovered". Though its characteristics are cally (endogenous form) or as infectious ROBERT C. GALLO strikingly similar to HTLV-1, HTLV-II is not agents (exogenous form)'·'. As do many so clearly linked to human disease. It is cu­ other animal species, humans have both forms ..... In general, rious that HTLV-11 is endemic in some American Indians and endogenous retroviruses are evolutionary relics of old infec­ more prevalent in drug addicts than HTLV-I"·'•. tions and are not known to cause disease. The DNA of many HIV-1 is also most prevalent in equatorial Africa, but in con­ species, including humans, harbours multiple copies of differ­ trast to HTLV the demography of the HIV epidemic is still in ent retroviral proviruses. The human endogenous proviral flux, and the virus is new to most of the world. The number of sequences are virtually all defective, and comprise about one infected people worldwide is now estimated to be about 17 mil­ percent of the human genome, though R. Kurth's group in lion and is predicted to reach 30 to SO million by the year 2000.
    [Show full text]
  • Marketing Safe Sex: the Politics of Sexuality, Race and Class in San Francisco, 1983 - 1991
    Marketing Safe Sex: The Politics of Sexuality, Race and Class in San Francisco, 1983 - 1991 Jennifer Brier Great Cities Institute College of Urban Planning and Public Affairs University of Illinois at Chicago Great Cities Institute Publication Number: GCP-06-06 A Great Cities Institute Working Paper May 2006 The Great Cities Institute The Great Cities Institute is an interdisciplinary, applied urban research unit within the College of Urban Planning and Public Affairs at the University of Illinois at Chicago (UIC). Its mission is to create, disseminate, and apply interdisciplinary knowledge on urban areas. Faculty from UIC and elsewhere work collaboratively on urban issues through interdisciplinary research, outreach and education projects. About the Author Jennifer Brier is Assistant Professor of Gender and Women’s Studies and History in the College of Liberal Arts and Sciences at the University of Illinois at Chicago. She was a GCI Faculty Scholar during the 2005 – 2006 academic year. She may be reached at [email protected]. Great Cities Institute Publication Number: GCP-06-06 The views expressed in this report represent those of the author(s) and not necessarily those of the Great Cities Institute or the University of Illinois at Chicago. This is a working paper that represents research in progress. Inclusion here does not preclude final preparation for publication elsewhere. Great Cities Institute (MC 107) College of Urban Planning and Public Affairs University of Illinois at Chicago 412 S. Peoria Street, Suite 400 Chicago IL 60607-7067
    [Show full text]
  • AIDS Office SFDPH.Tif
    :;J . AIDS Office ofthe San Francisco Department ofPublic Health - Records (MSS 95-01) 1982 - 1994 66 cubic feet The AIDS Office (AO)ofthe San Francisco Department ofPublic Health (SFDPH) is responsible for all non­ acute AIDS activities administered by the city. This includes surveillance, research, administration and oversight ofmuch ofthe city, state and federal funding ofAIDS related services, the coordination ofnon-acute care services for PWAs and HIV+ people, the coordination ofAIDS education and prevention programs, and planning and policy development related to AIDS for the city. Infonnation the AO collects is also passed on to appropriate state and federal offices (CDC, Nlli, etc) to help them understand what is occurring with AIDS and AIDS-related services in San Francisco. The responsibilities and activities ofeach branch ofthe AO and the duties ofindividual staffare described in the "Resource Directory" located in the folder marked "History and Description ofthe AIDS Office" located at the beginning ofCarton 1. Historical Sketch The initial response to the AIDS epidemic by the San Francisco Department ofPublic Health (SFDPH) was centered in the Bureau ofEpidemiology andDisease Control, which, until 1985, was the site ofmost AIDS­ related surveillance operations within San Francisco. In addition, in 1984 the AIDSActivities Office was fonned to identify needs, address health education, and arrange for funding ofAIDS-related services in San Francisco, with JeffAmory, Michael Bala and Gary Titus as the initial staff AIDS-related policy development and planning has also been done within the office ofthe Director ofPublic Health. Mervyn Silvennan was Director during the first halfofthe 1980s, handling numerous explosive issues such as the bathhouse dispute of 1984.
    [Show full text]
  • Hypervariable Region 3 Residues of HIV Type 1 Gp120 Involved in CCR5 Coreceptor Utilization: Therapeutic and Prophylactic Implications
    Proc. Natl. Acad. Sci. USA Vol. 96, pp. 4558–4562, April 1999 Medical Sciences Hypervariable region 3 residues of HIV type 1 gp120 involved in CCR5 coreceptor utilization: Therapeutic and prophylactic implications WEI-KUNG WANG,TIM DUDEK,MAX ESSEX, AND TUN-HOU LEE* Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA 02115 Communicated by Elkan R. Blout, Harvard Medical School, Cambridge, MA, February 17, 1999 (received for review November 2, 1998) ABSTRACT Crystallographic characterization of a ter- The coreceptor binding step of the HIV-1 life cycle is a nary complex containing a monomeric gp120 core, parts of potential target for therapeutic and prophylactic interventions. CD4, and a mAb, revealed a region that bridges the inner and To design intervention strategies targeting this critical step of outer domains of gp120. In a related genetic study, several HIV-1 entry requires knowing how V3 works in concert with residues conserved among primate lentiviruses were found to those residues in the bridging sheet to interact with CCR5, the play important roles in CC-chemokine receptor 5 (CCR5) chemokine coreceptor most often used by the so-called R5 coreceptor utilization, and all but one were mapped to the viruses of human and nonhuman primate lentiviruses (15, 16). bridging domain. To reconcile this finding with previous To that end, it is essential to provide a full account of V3 reports that the hypervariable region 3 (V3) of gp120 plays an residues involved in CCR5 utilization. In this study, we iden- important role in chemokine coreceptor utilization, elucidat- tified several V3 residues, both highly conserved and variable ing the roles of various V3 residues in this critical part of the ones, that were shown to play a role in CCR5 utilization.
    [Show full text]
  • Saturday Is for Funerals: a Book Review by Martin Adams
    Saturday is for funerals: A book review By Martin Adams According to the 2012 HIV/AIDS global fact sheet The final chapter – Government Action Makes a Difference: A .( www.kff.org), some 70% of those infected with HIV/AIDS live Nation Responds – describes what government and donors in Sub-Saharan Africa, which provides a home for some 12% of have done since 1996 to reduce fatalities and restore AIDS the world’s population. Further, 94% of the world’s children sufferers through drug therapy. Recent data offer promising who have HIV are estimated to live in SSA. Swaziland with signs that the national HIV/AIDS incidence (i.e. the rate of new 25.9% is believed to have the highest HIV prevalence in the infections per year) is declining in Botswana and to a lesser world. In Botswana in 2010, 24.8% of 15-49 year-olds were extent in countries in the region. But even in Botswana, in the found to be HIV positive. continuing absence of an effective vaccine, current rates of incidence will continue to increase the overall number Working on land matters in Africa, I have long been aware of infected. Even if death rates are reduced by 70-80% through the negative impact of AIDS on food security and on the un- effective treatment with ARVs, the rate of new infections certain tenure of widows and children. But, until recently, I would have to decrease by the same amount for HIV/AIDS had not really taken sufficient time to acquaint myself with the prevalence just to stay even.
    [Show full text]
  • HIV-AIDS Assignments Grade 11
    Oral History Center HIV/AIDS in American History Assignments – Grade 11 September 2020 For more information on curriculum, see the Oral History Center website. Table of Contents OVERVIEW ......................................................................................................................................... 2 PODCAST EPISODE 1 ........................................................................................................................... 2 THEMES .......................................................................................................................................................... 2 ASSIGNMENT: WORKING WITH THEMES IN THE HIV/AIDS INTERVIEWS ..................................................................... 3 Preliminary sample assignment: AIDS campaign.................................................................................... 3 FOUR POSSIBLE ASSIGNMENT TOPICS ................................................................................................. 3 ASSIGNMENT 1: WOMEN ON THE FRONT LINES: GENDER, IDENTITY, AND VALUES ....................................................... 3 Sample curriculum ................................................................................................................................... 4 Sample assignment ................................................................................................................................. 7 ASSIGNMENT 2: VIRUS HUNTERS: THE SEARCH FOR HIV ........................................................................................
    [Show full text]
  • 2012 Annual Report
    INSTITUTE OF HUMAN VIROLOGY 725 West Lombard Street | Baltimore, Maryland 21201-1009 INSTITUTE OF HUMAN VIROLOGY 410.706.8614 | 410.706.1952 fax | www.ihv.org Forging Global Connections and Initiating Global Leadership 2012 ANNUAL REPORT The Institute of Human Virology is a center at the University of Maryland School of Medicine and is affiliated with the University of Maryland Medical Center. For more information call Nora Grannell 410.706.8614 or visit www.ihv.org Our Mission The Institute of Human Virology was established to create and develop a world-class center of excellence focusing on chronic viral diseases, especially HIV/AIDS, and virally-linked cancers. The IHV is dedicated to the discovery, research, treatment and prevention of these diseases. Its unique structure seeks to connect cohesive, multi-disciplinary research and clinical programs so that new treatments are streamlined from discovery to patient. The IHV serves patients locally and the scientific community globally. 2 Contents Director’s Message ........................................................................4-5 IHV Leadership ..................................................................................6 About IHV .........................................................................................7 Division of Basic Science and Vaccine Development ...................8-17 Division of Clinical Care and Research ......................................18-21 Division of Epidemiology and Prevention .................................22-26 Global Virus Network
    [Show full text]