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Cinnamomum Burmanii) on the GROWTH of Staphylococcus Aureus BACTERIA

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Cinnamomum Burmanii) on the GROWTH of Staphylococcus Aureus BACTERIA THE EFFECT OF METHANOL EXTRACT OF CINNAMON BARK (Cinnamomum burmanii) ON THE GROWTH OF Staphylococcus aureus BACTERIA PENGARUH EKSTRAK METANOL KULIT BATANG KAYU MANIS (Cinnamomum burmannii) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus IDA WAHYUNI NIM. 105421104516 Skripsi Skripsi ini Diajukan Sebagai Salah Satu Syarat untuk Memperoleh Gelar Sarjana Kedokteran PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH MAKASSAR 2020 1 2 3 4 PERNYATAAN TIDAK PLAGIAT Yang bertanda tangan dibawah ini, Nama Lengkap : Ida Wahyuni Tanggal Lahir : Kajang, 27 Juni 1998 Tahun Masuk : 2016 Peminatan : Kedokteran Eksperimental Nama Pembimbing Akademik : dr. Rosdiana Sahabuddin, M. Kes, Sp. OG Nama Pembimbing Skripsi : dr. Zulfikar Tahir, M. Kes, Sp. An Menyatakan bahwa saya tidak melakukan kegiatan plagiat dalam penulisan skripsi saya yang berjudul : PENGARUH EKSTRAK METANOL KULIT BATANG KAYU MANIS (Cinnamomum burmannii) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Apabila suatu saat nanti terbukti saya melakukan tindakan plagiat, maka saya akan menerima sanksi yang telah ditetapkan. Demikian surat pernyataan ini saya buat untuk digunakan sebagaimana mestinya. Makassar, 12 Februari 2020 Ida Wahyuni NIM : 105421104516 5 RIWAYAT HIDUP PENULIS Nama : Ida Wahyuni Ayah : Drs. H. Mappijalang, M. Si Ibu : Hj. Sitti Sanawati, S.Pd Tempat, Tanggal Lahir : Kajang, 27 Juni 1998 Agama : Islam Alamat : Jl. Malengkeri Luar, Lorong 2 No. 21 Nomor Telepon/HP : 082216065287 Email : [email protected] RIWAYAT PENDIDIKAN SD Negeri 254 Tebba (2004-2010) SMP Negeri 1 Salomekko (2010-2013) SMA Negeri 10 Bone (2013-2016) Universitas Muhammadiyah Makassar (2016-2020) 6 -FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH MAKASSAR Skripsi, 12 Februari 2020 Ida Wahyuni, dr. Zulfikar Tahir, M. Kes, Sp. An 1Mahasiswa Fakultas Kedokteran dan Ilmu Kesehatan Universitas Muhammadiyah Makassar Angkatan 2016/ email [email protected] 2Pembimbing “PENGARUH EKSTRAK METANOL KULIT BATANG KAYU MANIS (Cinnamomum burmannii) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus” (xiii + 47 Halaman + 2 Tabel + 3 Gambar + 3 Lampiran) ABSTRAK Latar Belakang: Penyakit infeksi merupakan salah satu masalah kesehatan yang paling utama di negara-negara berkembang termasuk Indonesia. Salah satu penyebabnya adalah infeksi oleh bakteri sehingga antibiotik masih menjadi pilihan untuk mengatasinya saat ini. Staphylococcus aureus merupakan bakteri yang sering ditemukan pada telapak tangan. Oleh karena itu, diperlukan tindakan pengendalian untuk menghindari terjadinya infeksi. Tanaman Cinnamomum burmannii, diketahui mengandung zat aktif flavonoid, saponin, tanin, dan alkaloid yang memiliki kemampuan antibakteri sehingga dapat menghambat pertumbuhan bakteri. Tujuan Penelitian: Untuk mengetahui adanya pengaruh ekstrak metanol kulit batang kayu manis (Cinnamomum burmannii) terhadap pertumbuhan bakteri Staphylococcus aureus . Metode Penelitian: Merupakan penelitian true experimental. Sampel yang digunakan adalah ekstrak kulit batang Cinnamomum burmannii dan bakteri Staphylococcus aureus. Hasil: Hasil penelitian menunjukan terdapat pengaruh ekstrak metanol kulit batang Cinnamomum burmannii dengan rata-rata konsentrasi 20%, 30%, 40% yaitu 8,5 mm, 8,64 mm, dan 10 mm dalam 5 replikasi. Sementara kontrol positif yang menggunakan ciprofloxacin didapatkan yaitu 40,9 mm dan kontrol negatif aquades yaitu tidak ada pengaruh. Dari hasil tersebut didapatkan bahwa konsentrasi ekstrak Cinnamomum burmannii yang paling baik daya hambatnya yaitu pada konsentrasi 40% sebesar 11,1 mm pada sediaan MHA 2 dengan rata- rata konsentrasi 40% sebesar 10 mm sedangkan yang paling rendah pada konsentrasi 20% sebesar 8,0 mm pada MHA 4 dengan rata-rata konsentrasi 20% sebesar 8,5 mm. Kesimpulan: Ekstrak kulit batang Cinnamomum burmannii memiliki kemampuan sebagai antibakteri yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Kata Kunci: Cinnamomum burmannii, Staphylococcus aureus, zat aktif flavonoid, saponin, tanin, dan alkaloid. 7 FACULTY OF MEDICINE AND HEALTH SCIENCES MUHAMMADIYAH UNIVERSITY OF MAKASSAR Thesis, 12 February 2020 Ida Wahyuni, dr. Zulfikar Tahir, M. Kes, Sp. An 1Students of the Faculty of Medicine and Health Sciences at the University of Muhammadiyah Makassar in 2016/ email [email protected] 2Mentor “THE EFFECT OF METHANOL EXTRACT OF CINNAMON BARK (Cinnamomum burmanii) ON THE GROWTH OF Staphylococcus aureus BACTERIA” (xiii + 47 Pages + 2 Tables + 3 Images + 3 Attachment) ABSTRACT Background: Infectious disease is one of the most important health problems in developing countries including Indonesia. One of the causes is infection by bacterial so antibiotiocs are still the choice to overcome at this time. Staphylococcus aureus is a bacterium that is often found on the palm of the hand. Therefore, control measure are needed to avoid infection. Cinnamomum burmannii plants are known to contain active substances or compounds flavonoids, saponins, tannins, and alkaloids which have antibacterial ability so that they can inhibit bacterial growth. Objective: To determine the effect of methanol extract of cinnamon bark (Cinnamomum burmannii) on the growth of Staphylococcus aureus bacteria. Methods: Is a true experimental study. The sample used was Cinnamomum burmannii bark extract and Staphylococcus aureus Result: The result showed that there was an effect of Cinnamomum burmannii bark extract with an average concentration of 20%, 30%, 40% that is 8,5 mm, 8,64 mm, 10 mm in 5 replications. While positive control using ciprofloxacin was found to be 40,9 mm and negative control of aquades was no effect. From these result it was found that the concentration of Cinnamomum burmannii extract was 40% by 11,1 mm in MHA 2 preparations with an average concentration of 40% by 10 mm while the lowest at a concentration of 20% by 8,0 mm in MHA 4 with an average concentration of 20% by 8,5 mm. Conclusion: Cinnamomum burmannii bark extract has the ability as an antibacterial that can inhibit the growth of Staphylococcus aureus bacteria. Keyword: Cinnamomum burmannii, Staphylococcus aureus, active ingredients flavonoids, saponins, tannins, and alkaloids. 8 KATA PENGANTAR Segala puji bagi Allah SWT yang senantiasa tercurahkan atas segala limpahan rahmat dan nikmat-Nya. Sholawat serta salam semoga tetap tercurahkan kepada Rasulullah Muhammad SAW, karena beliaulah sebagai suritauladan yang membimbing manusia menuju surga. Alhamdulillah berkat hidayah dan pertolongan-Nya sehingga penulis dapat menyelesaikan skripsi dengan judul “Pengaruh Ekstrak Metanol Kulit Batang Kayu Manis (Cinnamomum burmannii) Terhadap Pertumbuhan Bakteri Staphylococcus aureus”. Penulisan skripsi ini merupakan salah satu syarat untuk menyelesaikan studi dan memperoleh gelar Sarjana Kedokteran dari Fakultas Kedokteran Universitas Muhammadiyah Makassar. Pada kesempatan ini penulis ingin mengucapkan terima kasih yang tak terhingga kepada orang tua penulis, ayahanda Drs. H. Mappijalang, M.Si dan ibunda Hj. Sitti Sanawati, S.Pd yang senantiasa sabar dan selalu memberikan motivasi serta tidak henti-hentinya memanjatkan doa sehingga penulis mampu menyelesaikan skripsi ini. Secara khusus penulis ingin menyampaikan rasa hormat dan terima kasih yang sebanyak-banyaknya kepada dr. Zulfikar Tahir, M. Kes, Sp. An selaku pembimbing yang telah meluangkan waktu untuk membimbing dan memberikan koreksi selama proses penyusunan skripsi ini hingga selesai. Selanjutnya penulis juga ingin mengucapkan terima kasih kepada : 1. Rektor Universitas Muhammadiyah Makassar yang telah memberikan 9 kesempatan kepada penulis untuk memperoleh ilmu pengetahuan di Universitas Muhammadiyah Makassar. 2. Dekan Fakultas Kedokteran Universitas Muhammadiyah Makassar, Ayahanda dr.H.Machmud Gaznawi, Sp.PA(K) yang telah memberikan sarana dan prasarana sehingga penulis dapat menyelesaikan pendidikan ini dengan baik. 3. Seluruh dosen dan staf di Fakultas Kedokteran Universitas Muhammadiyah Makassar. 4. dr. Rosdiana Sahabuddin, M. Kes, Sp. OG selaku pembimbing akademik saya yang telah memberikan semangat dan motivasi agar penulis dapat menyelesaikan skripsi ini tepat waktu. 5. Teman-teman bimbingan skripsi, Dwi Agung Setiawan dan Muti‟a Mustatira Razak yang senantiasa memberikan semangat dalam menyelesaikan penelitian ini. 6. Teman-teman sejawat angkatan 2016 Rauvolfia yang selalu mendukung dan memberikan saran dan semangat. 7. Sahabat-sahabatku dari SMA, Uni, Hana, Uppy, Kiki, Evi, Widya, Dede, Desi dan Lisa yang selalu memberikan dukungan dalam menyelesaikan skripsi ini. 8. Sahabat-sahabatku sejak menjadi mahasiswa baru di Fakultas Kedokteran sampai sekarang, Egah, Wiwi, dan Khintan yang selalu membantu memberikan saran dalam proses penyelesaian skripsi ini. 10 9. Teman-teman belajar saya selama di Fakultas Kedokteran Ana, Ilmi, dan Andev yang selalu memberi semangat dalam menyelesaikan skripsi ini. 10. Saudariku Nurul Sulfiani yang selalu memberikan motivasi belajar untuk tidak cepat menyerah dan selalu memberikan semangat. Penulis menyadari bahwa skripsi ini masih jauh dari yang diharapkan oleh karena itu dengan segala kerendahan hati penulis akan senang dalam menerima kritik dan saran demi perbaikan dan kesempurnaan skripsi ini. Namun penulis berharap semoga tetap dapat memberikan manfaat pada pembaca, masyarakat dan penulis lain. Akhir kata, saya berharap Allah SWT membalas segala kebaikan semua pihak yang telah membantu. Makassar, Februari 2020 Penulis 11 DAFTAR ISI HALAMAN JUDUL PERNYATAAN PERSETUJUAN PEMBIMBING PERNYATAAN PERSETUJUAN
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