No. Pek/Com/208/3/2016 Embassy of India Trade & Commerce Wing
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Perillyl Alcohol Conjugate Downregulates O6-Methylguanin DNA Methltransferase Via Inducing Ubiquitination-De
Song et al. Cell Death and Disease (2018) 9:202 DOI 10.1038/s41419-017-0193-2 Cell Death & Disease ARTICLE Open Access Temozolomide–perillyl alcohol conjugate downregulates O6- methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer Xingguo Song1,LiXie1,2,MinghuiChang2,3,XinranGeng4,XingwuWang1,ThomasC.Chen5 and Xianrang Song 1,2 Abstract The DNA repair enzyme O6-methylguanin-DNA-methltransferase (MGMT) is able to remove products of alkylating agent such as O6-meG and emerges as a central determinant of cancer resistance to temozolomide (TMZ). Temozolomide–perillyl alcohol conjugate (TMZ–POH), a novel TMZ analog developed based on the conjugation of TMZ and POH, displayed strong anticancer potency in multiple cancer types, but seemed not to experience the chemoresistance even in cells with high MGMT expression unlike TMZ and other alkylating agents. In this study, we demonstrated TMZ–POH inhibited MGMT dependent on proteasomal pathway and this inhibition is a significant factor in its toxic effect in the non-small cell lung cancer (NSCLC) cells. 1234567890():,; 1234567890():,; Introduction such as O6-methyl-guanine (O6-meG), which trigger cell Nowadays, chemotherapy has been traditionally con- cycle-dependent DNA damage and cell death4. Although sidered as one of the standard treatment options for TMZ chemotherapy may enhance survival of cancer cancer patients, but the chemoresistance dramatically patients, intrinsic or acquired resistance to TMZ is also hinders its clinical application, especially for alkylating common and accounts for many treatment failures5, agents like temozolomide (TMZ)1. TMZ, an imidazote- because TMZ-induced DNA alkylation damage can be trazine derivative of the alkylating agent dacarbazine, was repaired by O6-methylguanin-DNA-methltransferase approved by the US FDA (Food and Drug Administration) (MGMT)6. -
Annual Report 2019 X
CHAPTER I Definition 2 CHAPTER XI Corporate Governance Report 102 CHAPTER II Risk Warnings 5 I. Overview of Corporate Governance 102 CHAPTER III Company Profile 6 II. General Meeting 102 I. Profile 6 III. Performance of the Directors 104 II. History 9 IV. Work Performance of Board of Directors and 111 III. Staff Profile 11 Special Committees IV. Brief Introduction of the Organs and Branches 12 V. Chairman and General Manager 123 V. Basic Information about the Industry in Which the 16 VI. Securities Transactions by the Directors, Supervisors and 125 Company Operates Senior Management VI. Business Briefings of the Company 16 VII. Performance of Duties by Independent Non-executive 125 VII. Briefings of our Subsidiaries 17 Directors VIII. Honours Awarded to the Company During the 18 VIII. Supervision on Risk Management and Internal Control 125 Reporting Period System CHAPTER IV Financial Summary 20 IX. Other Relevant Matters 128 I. Major Accounting Data of the Group 20 CHAPTER XII Internal Control 133 II. Major Financial Indexes of the Group 20 I. Establishment of Internal Control Structure 133 III. Net Capital of the Company and Relevant Risk Control 21 II. Implementation and Operation of Internal Control System 133 Indicators III. Supervision and Inspection of Internal Control 133 IV. Financial Conditions of the Group of the Latest Five Years 22 IV. Conclusion of the Assessment of Internal Control 134 CHAPTER V Chairman Statement 23 CHAPTER XIII Independent Auditor’s Report 135 CHAPTER VI Management Discussion and Analysis 25 CHAPTER XIV Notes to the Consolidated Financial 140 I. Economic and Futures Market Analysis during the 25 Statements Reporting Period Consolidated Statements of Comprehensive Income 140 II. -
Urban Growth in Tianjin, 1993–2003
Urban growth in Tianjin, 1993–2003 Liu Yun September, 2004 Urban growth in Tianjin, 1993–2003 by Liu Yun Thesis submitted to the International Institute for Geo-information Science and Earth Observation in partial fulfilment of the requirements for the degree of Master of Science in ………………………… (fill in the name of the course) Thesis Assessment Board Prof. Dr. D. Webster (Chairman) Prof. Dr. H.F.L. Ottens (external examiner, University Utrecht) Prof. (Douglas) Webster (First ITC supervisor) MSc. R.V. (Richard) Sliuzas (Second ITC supervisor) Mrs Du-Ningrui Msc (SUS supervisor) INTERNATIONAL INSTITUTE FOR GEO-INFORMATION SCIENCE AND EARTH OBSERVATION ENSCHEDE, THE NETHERLANDS I certify that although I may have conferred with others in preparing for this assignment, and drawn upon a range of sources cited in this work, the content of this thesis report is my original work. Signed ……… Liu Yun ……………. Disclaimer This document describes work undertaken as part of a programme of study at the International Institute for Geo-information Science and Earth Observation. All views and opinions expressed therein remain the sole responsibility of the author, and do not necessarily represent those of the institute. Abstract Chinese cities have experienced a period of rapid urban expansion since the socialist market economic was approved in 1993. The urbanization level increased from 28% in 1993 to 40% in year 2003. As a metropolitan with the third largest population in China, Tianjin city also has made the rapid urban growth under this macro background. Here Tianjin is chosen as the case city to know what is going on about urban development in Chinese big. -
Hydrogen Fuel Cell Vehicles Development Summit & Press Conference of Blue Book of Hydrogen Vehicle
China Automotive Technology & Research Center Co., Ltd. Notice on 2019 China (Tianjin) Hydrogen Fuel Cell Vehicles Development Summit & Press Conference of Blue Book of Hydrogen Vehicle (2019) Hydrogen energy is a clean energy carrier of strategic significance, while fuel cell vehicle (FCV) is the important direction of new energy vehicle (NEV) development. Promotion and application of FCVs plays a significant role in hydrogen energy popularization. As the hydrogen energy technology keeps making progress in industrialization and FCVs demonstrative operation scale expands rapidly, the development of hydrogen energy industry gains attention of the national level. During the NPC & CPPCC this year, the Report on the Work of the Government for the first time proposed to “promote construction of facilities such as charging and hydrogen refueling stations”. In October 2019, the State Council organized a meeting of the National Energy Commission. The meeting emphasized to “explore commercial route for the advanced energy storage and hydrogen energy”. Since this year, China has made great progress in development of automotive hydrogen industry. The hydrogen energy technology engineering and industrialization promotes steadily; the progress of independent automotive fuel cell technology speeds up; superior enterprises have preliminarily formed technology R&D system and product development system; the industrial organization mode innovation becomes more active, and industrial supporting system development is accelerating. In the meantime, the FCV demonstrative operation zone and scale is further expanded; hydrogen refueling technology level and service ability is further improved; the business mode of FCV operation and hydrogen refueling station construction has taken shape gradually. Facing the new development trend, Beijing CATARC Science& Technology Center Co., Ltd., the wholly-owned subsidiary of China Automotive Technology & Research Center Co., Ltd. -
Bank of Zhengzhou Co., Ltd.* 鄭州銀行股份有限公司 *
Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement. Bank of Zhengzhou Co., Ltd.* 鄭州銀行股份有限公司* (A joint stock company incorporated in the People’s Republic of China with limited liability) (H Shares Stock Code: 6196) (Preference Shares Stock Code: 4613) ANNOUNCEMENT OF ANNUAL RESULTS FOR THE YEAR ENDED DECEMBER 31, 2020 The board of directors (the “Board”) of Bank of Zhengzhou Co., Ltd.* (the “Bank”) is pleased to announce the audited consolidated annual results (the “Annual Results”) of the Bank and its subsidiaries for the year ended December 31, 2020. This results announcement, containing the full text of the 2020 annual report of the Bank, complies with the relevant content requirements of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited in relation to preliminary announcements of Annual Results. The Board and the audit committee of the Board have reviewed and confirmed the Annual Results. This results announcement is published on the websites of The Stock Exchange of Hong Kong Limited (www.hkexnews.hk) and the Bank (www.zzbank.cn). The printed version of the annual report for the year ended December 31, 2020 will be despatched to the shareholders of the Bank and will be available on the above websites in April 2021. -
ATTACHMENT 1 Barcode:3800584-02 C-570-107 INV - Investigation
ATTACHMENT 1 Barcode:3800584-02 C-570-107 INV - Investigation - Chinese Producers of Wooden Cabinets and Vanities Company Name Company Information Company Name: A Shipping A Shipping Street Address: Room 1102, No. 288 Building No 4., Wuhua Road, Hongkou City: Shanghai Company Name: AA Cabinetry AA Cabinetry Street Address: Fanzhong Road Minzhong Town City: Zhongshan Company Name: Achiever Import and Export Co., Ltd. Street Address: No. 103 Taihe Road Gaoming Achiever Import And Export Co., City: Foshan Ltd. Country: PRC Phone: 0757-88828138 Company Name: Adornus Cabinetry Street Address: No.1 Man Xing Road Adornus Cabinetry City: Manshan Town, Lingang District Country: PRC Company Name: Aershin Cabinet Street Address: No.88 Xingyuan Avenue City: Rugao Aershin Cabinet Province/State: Jiangsu Country: PRC Phone: 13801858741 Website: http://www.aershin.com/i14470-m28456.htmIS Company Name: Air Sea Transport Street Address: 10F No. 71, Sung Chiang Road Air Sea Transport City: Taipei Country: Taiwan Company Name: All Ways Forwarding (PRe) Co., Ltd. Street Address: No. 268 South Zhongshan Rd. All Ways Forwarding (China) Co., City: Huangpu Ltd. Zip Code: 200010 Country: PRC Company Name: All Ways Logistics International (Asia Pacific) LLC. Street Address: Room 1106, No. 969 South, Zhongshan Road All Ways Logisitcs Asia City: Shanghai Country: PRC Company Name: Allan Street Address: No.188, Fengtai Road City: Hefei Allan Province/State: Anhui Zip Code: 23041 Country: PRC Company Name: Alliance Asia Co Lim Street Address: 2176 Rm100710 F Ho King Ctr No 2 6 Fa Yuen Street Alliance Asia Co Li City: Mongkok Country: PRC Company Name: ALMI Shipping and Logistics Street Address: Room 601 No. -
Tianjin WLAN Area
Tianjin WLAN area NO. SSID Location_Name Location_Type Location_Address City Province 1 ChinaNet Tianjin City Nine Dragons Paper Ltd. No. 1 Dormitory Building Others Nine Dragons Road, Economic Development Zone, Ninghe County, Tianjin Tianjin City Tianjin City 2 ChinaNet Tianjin City Hebei District Kunwei Road Telecom Business Hall Telecom's Own No.3, Kunwei Road, Hebei District, Tianjin Tianjin City Tianjin City 3 Chiat Tianjin Polytechnic University Heping Campus Office Building School No.1, Xizang Road, Heping District, Tianjin Tianjin City Tianjin City 4 Chiat Tianjin City Heping District Jiayi Apartment No.4 Building Business Building Jiayi Apartment, Diantai Road, Heping District, Tianjin Tianjin City Tianjin City Tianjin City Hexi District Institute of Foreign Economic Relations and 5 Chiat School Zhujiang Road, Hexi District, Tianjin Tianjin City Tianjin City Trade 6 Chiat Tianjin City Hexi District Tiandu Gem Bath Center Hotel Zijinshan Road, Hexi District, Tianjin Tianjin City Tianjin City 7 Chiat Tianjin City Hexi District Rujia Yijun Hotel Hotel No.1, Xuzhou Road , Hexi District, Tianjin Tianjin City Tianjin City Government agencies 8 Chiat Tianjin City Hexi District Tianbin Business Center Binshui Road, Hexi District, Tianjin Tianjin City Tianjin City and other institutions 9 Chiat Tianjin City Hexi District Science and Technology Mansion Business Building Youyi Road, Hexi District, Tianjin Tianjin City Tianjin City 10 Chiat Tianjin City Beichen District Shengting Hotel Hotel Sanqian Road and Xinyibai Road, Beichen District, -
Air-Insulated Medium-Voltage Switchgear Nxairs, 24Kv
Air-insulated Medium-Voltage Switchgear NXAirS, 24kV siemens.com.cn/energy-management Air-insulated Medium-Voltage Switchgear NXA irS,24kV Contents Application Types Application Circuit-breaker switchgear NXAirS, is factory-assembled, type-tested, Types metal-enclosed and metal-clad switchgear for indoor installation accoording Typical uses to GB3906, DL404 and IEC 62271-200.. Classification Loss of service continuity category LSC2B (Metal clad) Partition class PM(Metal) Requirements Internal arc classification IAC A FLR ISC≤31.5kA Customer benefits and features arc duration=1s Technical Data Electrical data and dimensions Design data Transportation and packing Primary Solution NXAirS 24kV Design Design of switchgear Components Vacuum circuit-breaker Standards Standards, specifications, guidelines NXAirS panel Maxium rating 24kV/31.5kA/3150A 2 Air-insulated Medium-Voltage Switchgear NXA irS,24kV Air-insulated Medium-Voltage Switchgear NXAirS,24kV Contents Application Application Types Application Typical uses Classification Application Circuit-breaker switchgear NXAirS, is factory-assembled, type-tested, NXAirS circuit-breaker switchgear is used in NXAirS switchgear correspond to the following classifications according to GB3906, Types metal-enclosed and metal-clad switchgear for indoor installation accoording Typical uses substations and distribution system, mainly at the DL404 and IEC62271-200. to GB3906, DL404 and IEC 62271-200.. Classification primary distribution level. E.g. Loss of service continuity category Loss of service continuity -
An Chengri an Chengri, Male, Born in November, 1964.Professor. Director
An Chengri , male, born in November, 1964.Professor. Director of Institute of International Studies, Department of Political Science, School of philosophy and Public Administration,Heilongjiang University. Ph. D student of Japanese politics and Diplomacy History, NanKai University,2001.Doctor(International Relations History), Kokugakuin University,2002. Research Orientation: Japanese Foreign Relations, International Relation History in East Asia Publications: Research on contemporary Japan-South Korea Relations(China Social Science Press,October,2008);International Relations History of East Asia(Jilin Science Literature Press,March,2005) Association: Executive Director of China Institute of Japanese History , Director of China Society of Sino-Japanese Relations History Address: No.74 Xuefu Road, Nangang District, Haerbin, Heilongjiang, Department of Political Science, School of philosophy and Public Administration,Heilongjiang University. Postcode: 150080 An shanhua , Female, born in July,1964. Associate Professor, School of History, Dalian University. Doctor( World History),Jilin University,2007. Research Orientation: Modern and contemporary Japanese History, Japanese Foreign Relations, Political Science Publications: Comparative Studies on World Order View of China Korea and Japan and their Diplomatic in Modern Time ( Japanese Studies Forum , Northeast Normal University, 2006); Analysis of Japan's anti-system ideology towards the international system ( Journal of Changchun University of Science and Technology , Changchun University,2006) -
Table of Codes for Each Court of Each Level
Table of Codes for Each Court of Each Level Corresponding Type Chinese Court Region Court Name Administrative Name Code Code Area Supreme People’s Court 最高人民法院 最高法 Higher People's Court of 北京市高级人民 Beijing 京 110000 1 Beijing Municipality 法院 Municipality No. 1 Intermediate People's 北京市第一中级 京 01 2 Court of Beijing Municipality 人民法院 Shijingshan Shijingshan District People’s 北京市石景山区 京 0107 110107 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Haidian District of Haidian District People’s 北京市海淀区人 京 0108 110108 Beijing 1 Court of Beijing Municipality 民法院 Municipality Mentougou Mentougou District People’s 北京市门头沟区 京 0109 110109 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Changping Changping District People’s 北京市昌平区人 京 0114 110114 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Yanqing County People’s 延庆县人民法院 京 0229 110229 Yanqing County 1 Court No. 2 Intermediate People's 北京市第二中级 京 02 2 Court of Beijing Municipality 人民法院 Dongcheng Dongcheng District People’s 北京市东城区人 京 0101 110101 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Xicheng District Xicheng District People’s 北京市西城区人 京 0102 110102 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Fengtai District of Fengtai District People’s 北京市丰台区人 京 0106 110106 Beijing 1 Court of Beijing Municipality 民法院 Municipality 1 Fangshan District Fangshan District People’s 北京市房山区人 京 0111 110111 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Daxing District of Daxing District People’s 北京市大兴区人 京 0115 -
Wang, Weikai (2020) the Discourse, Governance and Configurations of Polycentricity in Transitional China: a Case Study of Tianjin
Wang, Weikai (2020) The discourse, governance and configurations of polycentricity in transitional China: a case study of Tianjin. PhD thesis. https://theses.gla.ac.uk/81666/ Copyright and moral rights for this work are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge This work cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given Enlighten: Theses https://theses.gla.ac.uk/ [email protected] The Discourses, Governance and Configurations of Polycentricity in Transitional China: A Case Study of Tianjin Weikai Wang BSc, MSc Peking University Submitted in fulfilment of the requirements for the Degree of Philosophy School of Social and Political Sciences College of Social Science University of Glasgow September 2020 Abstract Polycentricity has been identified as a prominent feature of modern landscapes as well as a buzzword in spatial planning at a range of scales worldwide. Since the Reform and Opening- up Policy in 1978, major cities in China have experienced significant polycentric transition manifested by their new spatial policy framework and reshaped spatial structure. The polycentric transformation has provoked academics’ interests on structural and performance analysis in quantitative ways recently. However, little research investigates the nature of (re)formation and implementation of polycentric development policies in Chinese cities from a processual and critical perspective. -
Addition of Clopidogrel to Aspirin in 45 852 Patients with Acute Myocardial Infarction: Randomised Placebo-Controlled Trial
Articles Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group* Summary Background Despite improvements in the emergency treatment of myocardial infarction (MI), early mortality and Lancet 2005; 366: 1607–21 morbidity remain high. The antiplatelet agent clopidogrel adds to the benefit of aspirin in acute coronary See Comment page 1587 syndromes without ST-segment elevation, but its effects in patients with ST-elevation MI were unclear. *Collaborators and participating hospitals listed at end of paper Methods 45 852 patients admitted to 1250 hospitals within 24 h of suspected acute MI onset were randomly Correspondence to: allocated clopidogrel 75 mg daily (n=22 961) or matching placebo (n=22 891) in addition to aspirin 162 mg daily. Dr Zhengming Chen, Clinical Trial 93% had ST-segment elevation or bundle branch block, and 7% had ST-segment depression. Treatment was to Service Unit and Epidemiological Studies Unit (CTSU), Richard Doll continue until discharge or up to 4 weeks in hospital (mean 15 days in survivors) and 93% of patients completed Building, Old Road Campus, it. The two prespecified co-primary outcomes were: (1) the composite of death, reinfarction, or stroke; and Oxford OX3 7LF, UK (2) death from any cause during the scheduled treatment period. Comparisons were by intention to treat, and [email protected] used the log-rank method. This trial is registered with ClinicalTrials.gov, number NCT00222573. or Dr Lixin Jiang, Fuwai Hospital, Findings Allocation to clopidogrel produced a highly significant 9% (95% CI 3–14) proportional reduction in death, Beijing 100037, P R China [email protected] reinfarction, or stroke (2121 [9·2%] clopidogrel vs 2310 [10·1%] placebo; p=0·002), corresponding to nine (SE 3) fewer events per 1000 patients treated for about 2 weeks.