BIODIVERSITAS ISSN: 1412-033X Volume 21, Number 10, October 2020 E-ISSN: 2085-4722 Pages: 4732-4740 DOI: 10.13057/biodiv/d211037 Metabolic profile and skin-related bioactivities of Cerioporus squamosus hydromethanolic extract WAILL A. ELKHATEEB1, GHOSON M. DABA1,, MARWA O. ELNAHAS1, PAUL W. THOMAS2,3, MAHMOUD EMAM4,5, 1Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Division, National Research Centre. Dokki, Giza, 12622, Egypt. Tel. +201013241936, Fax.: +20233370931, email:
[email protected] 2University of Stirling, Stirling, UK. 3Mycorrhizal Systems Ltd., Lancashire, UK. 4College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology. Hangzhou 310014, China. Tel. +201063802898, Fax.: +20233370931, email:
[email protected] 5Department of Phytochemistry and Plant Systematics, National Research Centre. 33 El Bohouth St., Dokki, Giza 12622, Egypt Manuscript received: 12 July 2020. Revision accepted: 23 September 2020. Abstract. Elkhateeb WA, Daba GM, Elnahas MO, Thomas PW, Emam M. 2020. Metabolic profile and skin-related bioactivities of Cerioporus squamosus hydromethanolic extract. Biodiversitas 21: 4732-4740. Being a functional food capable of showing nutritional as well as medicinal properties have great attention. Mushrooms have been proven as leading targets in this field. For this purpose, the edible mushroom Cerioporus squamosus was investigated in this study to evaluate the in vitro skin-related bioactivities of its hydromethanolic extract in terms of enhancing wound healing, and human skin cancer suppression capabilities. Treatment of fibroblast cells (BJ-1) with the hydromethanolic extract of this mushroom at 50 µg/mL enhanced cell migration rates by 71.7% after 24 h of exposure to the extract.