Mouth, Tongue, Pharynx & Palate
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A Cellular Mechanism for Main and Accessory Olfactory Integration at the Medial Amygdala
The Journal of Neuroscience, February 17, 2016 • 36(7):2083–2085 • 2083 Journal Club Editor’s Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see http://www.jneurosci.org/misc/ifa_features.shtml. A Cellular Mechanism for Main and Accessory Olfactory Integration at the Medial Amygdala E. Mae Guthman1* and XJorge Vera2* 1Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, and 2Departamento de Biología, Universidad de Chile, Santiago, Chile, 7800003 Review of Keshavarzi et al. Many vertebrates rely on their accessory (Sua´rez et al., 2012). Chemical cues reach thalamus (Keshavarzi et al., 2014), and and main olfactory systems (AOS and the AOS at a specialized sensory epithe- predator odors activate neurons in both re- MOS, respectively) to interact with their lium located in the vomeronasal organ gions (Pe´rez-Go´mez et al., 2015). Ventro- environment. Shaped by evolution to (VNO), a close-ended tubular structure medial hypothalamic neuronal activity is drive the perception of volatile and non- connected to the nostrils and positioned both necessary (Kunwar et al., 2015) and volatile molecules (for review, see Sua´rez at the base of the medial septum. The sufficient (Kunwar et al., 2015; Pe´rez- et al., 2012), these sensory systems allow VNO is sequestered from airflow; thus, Go´mez et al., 2015) to drive defensive be- animals to react and learn about the the chemical cues must solubilize with na- haviors. -
The Myloglossus in a Human Cadaver Study: Common Or Uncommon Anatomical Structure? B
Folia Morphol. Vol. 76, No. 1, pp. 74–81 DOI: 10.5603/FM.a2016.0044 O R I G I N A L A R T I C L E Copyright © 2017 Via Medica ISSN 0015–5659 www.fm.viamedica.pl The myloglossus in a human cadaver study: common or uncommon anatomical structure? B. Buffoli*, M. Ferrari*, F. Belotti, D. Lancini, M.A. Cocchi, M. Labanca, M. Tschabitscher, R. Rezzani, L.F. Rodella Section of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy [Received: 1 June 2016; Accepted: 18 July 2016] Background: Additional extrinsic muscles of the tongue are reported in literature and one of them is the myloglossus muscle (MGM). Since MGM is nowadays considered as anatomical variant, the aim of this study is to clarify some open questions by evaluating and describing the myloglossal anatomy (including both MGM and its ligamentous counterpart) during human cadaver dissections. Materials and methods: Twenty-one regions (including masticator space, sublin- gual space and adjacent areas) were dissected and the presence and appearance of myloglossus were considered, together with its proximal and distal insertions, vascularisation and innervation. Results: The myloglossus was present in 61.9% of cases with muscular, ligamen- tous or mixed appearance and either bony or muscular insertion. Facial artery pro- vided myloglossal vascularisation in the 84.62% and lingual artery in the 15.38%; innervation was granted by the trigeminal system (buccal nerve and mylohyoid nerve), sometimes (46.15%) with hypoglossal component. Conclusions: These data suggest us to not consider myloglossus as a rare ana- tomical variant. -
The Pattern of Olfactory Innervation by W
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.9.3.101 on 1 July 1946. Downloaded from THE PATTERN OF OLFACTORY INNERVATION BY W. E. LE GROS CLARK and R. T. TURNER WARWICK From the Department of Anatomy, University of Oxford (RECEIVED 31ST JULY, 1946) IT is desirable that, from time to time, commonly Methods accepted statements regarding anatomical pathways Most of the observations recorded in this paper were and connexions in the peripheral and central nervous made on rabbit material. The fixation of the olfactory systems should be carefully reviewed in the light of mucosa presented considerable difficulty. The method modern technical methods of investigation, for it finally selected, because it gave the best results with must be admitted that not a few of these statements protargol and was also adequate for the other stains are based on old methods which are now recognized employed, was perfusion of 70 per cent. alcohol through to be too crude to permit of really accurate con- the aorta, after preliminary washing through with normal clusions. In recent years, indeed, a number of saline, as recommended by Bodian (1936). Another facts have been shown unexpected difficulty arose from the fact that a large apparently well-established number of laboratory rabbits suffer from a chronic by critical studies to be erroneous. For example, rhinitis which leads to gross pathological changes in the the so-called ventral nucleus of the lateral geniculate olfactory mucosa. Consequently, a considerable pro- Protected by copyright. body and the pulvinar are no longer accepted as portion of our material, experimental and otherwise, terminal stations of the optic tract, and the strie had to be discarded as useless. -
Ear Pain in Patients with Oropharynx Carcinoma: Karlt.Beer Peter Vock How MRI Contributes to the Explanation Richard H
Eur Radiol (2004) 14:2206–2211 DOI 10.1007/s00330-004-2340-2 HEAD AND NECK Harriet C. Thoeny Ear pain in patients with oropharynx carcinoma: KarlT.Beer Peter Vock how MRI contributes to the explanation Richard H. Greiner of a prognostic and predictive symptom Received: 22 October 2003 Abstract Reflex otalgia is a predic- glossus muscle, stylopharyngeus Revised: 11 March 2004 tive and prognostic parameter for lo- muscle, hyoglossus muscle and pre- Accepted: 5 April 2004 cal control in patients with orophar- epiglottic space. No difference was Published online: 1 May 2004 ynx carcinoma. Can a morphologic found for the muscles of mastication, © Springer-Verlag 2004 correlate of this important symptom levator and tensor veli palatini mus- be detected by MRI? Thirty-six pa- cles, styloglossus muscle, genioglos- tients were prospectively evaluated sus muscle, intrinsic muscles of the by MRI before radical radiotherapy. tongue, digastric muscles, mucosal Sixteen patients had reflex otalgia; surface of the lateral and posterior 20 did not. The oropharynx and adja- pharyngeal wall, uvula, valleculae, cent regions were analyzed. Alter- parapharyngeal space and larynx. An ation was defined as effacement of alteration of structures innervated by H. C. Thoeny (✉) · P. Vock anatomical structures, signal alter- the glossopharyngeal nerve was vi- Department of Diagnostic Radiology, ation or enhancement after contrast sualized on MRI significantly more Inselspital, χ2 University of Bern, medium administration. The -test often when reflex otalgia was pres- Freiburgstrasse 10, 3010 Bern, Switzerland was used to compare categorical pa- ent. Involvement of structures inner- e-mail: [email protected], rameters. In patients with reflex vated by other cranial nerves did not [email protected] otalgia, alteration of the following show the same association with ear Tel.: +41-31-6322939 structures innervated by the glosso- pain. -
Atlas of the Facial Nerve and Related Structures
Rhoton Yoshioka Atlas of the Facial Nerve Unique Atlas Opens Window and Related Structures Into Facial Nerve Anatomy… Atlas of the Facial Nerve and Related Structures and Related Nerve Facial of the Atlas “His meticulous methods of anatomical dissection and microsurgical techniques helped transform the primitive specialty of neurosurgery into the magnificent surgical discipline that it is today.”— Nobutaka Yoshioka American Association of Neurological Surgeons. Albert L. Rhoton, Jr. Nobutaka Yoshioka, MD, PhD and Albert L. Rhoton, Jr., MD have created an anatomical atlas of astounding precision. An unparalleled teaching tool, this atlas opens a unique window into the anatomical intricacies of complex facial nerves and related structures. An internationally renowned author, educator, brain anatomist, and neurosurgeon, Dr. Rhoton is regarded by colleagues as one of the fathers of modern microscopic neurosurgery. Dr. Yoshioka, an esteemed craniofacial reconstructive surgeon in Japan, mastered this precise dissection technique while undertaking a fellowship at Dr. Rhoton’s microanatomy lab, writing in the preface that within such precision images lies potential for surgical innovation. Special Features • Exquisite color photographs, prepared from carefully dissected latex injected cadavers, reveal anatomy layer by layer with remarkable detail and clarity • An added highlight, 3-D versions of these extraordinary images, are available online in the Thieme MediaCenter • Major sections include intracranial region and skull, upper facial and midfacial region, and lower facial and posterolateral neck region Organized by region, each layered dissection elucidates specific nerves and structures with pinpoint accuracy, providing the clinician with in-depth anatomical insights. Precise clinical explanations accompany each photograph. In tandem, the images and text provide an excellent foundation for understanding the nerves and structures impacted by neurosurgical-related pathologies as well as other conditions and injuries. -
Appendix B: Muscles of the Speech Production Mechanism
Appendix B: Muscles of the Speech Production Mechanism I. MUSCLES OF RESPIRATION A. MUSCLES OF INHALATION (muscles that enlarge the thoracic cavity) 1. Diaphragm Attachments: The diaphragm originates in a number of places: the lower tip of the sternum; the first 3 or 4 lumbar vertebrae and the lower borders and inner surfaces of the cartilages of ribs 7 - 12. All fibers insert into a central tendon (aponeurosis of the diaphragm). Function: Contraction of the diaphragm draws the central tendon down and forward, which enlarges the thoracic cavity vertically. It can also elevate to some extent the lower ribs. The diaphragm separates the thoracic and the abdominal cavities. 2. External Intercostals Attachments: The external intercostals run from the lip on the lower border of each rib inferiorly and medially to the upper border of the rib immediately below. Function: These muscles may have several functions. They serve to strengthen the thoracic wall so that it doesn't bulge between the ribs. They provide a checking action to counteract relaxation pressure. Because of the direction of attachment of their fibers, the external intercostals can raise the thoracic cage for inhalation. 3. Pectoralis Major Attachments: This muscle attaches on the anterior surface of the medial half of the clavicle, the sternum and costal cartilages 1-6 or 7. All fibers come together and insert at the greater tubercle of the humerus. Function: Pectoralis major is primarily an abductor of the arm. It can, however, serve as a supplemental (or compensatory) muscle of inhalation, raising the rib cage and sternum. (In other words, breathing by raising and lowering the arms!) It is mentioned here chiefly because it is encountered in the dissection. -
Anatomy, Histology, and Embryology
ANATOMY, HISTOLOGY, 1 AND EMBRYOLOGY An understanding of the anatomic divisions composed of the vomer. This bone extends from of the head and neck, as well as their associ- the region of the sphenoid sinus posteriorly and ated normal histologic features, is of consider- superiorly, to the anterior edge of the hard pal- able importance when approaching head and ate. Superior to the vomer, the septum is formed neck pathology. The large number of disease by the perpendicular plate of the ethmoid processes that involve the head and neck area bone. The most anterior portion of the septum is a reflection of the many specialized tissues is septal cartilage, which articulates with both that are present and at risk for specific diseases. the vomer and the ethmoidal plate. Many neoplasms show a sharp predilection for The supporting structure of the lateral border this specific anatomic location, almost never of the nasal cavity is complex. Portions of the occurring elsewhere. An understanding of the nasal, ethmoid, and sphenoid bones contrib- location of normal olfactory mucosa allows ute to its formation. The lateral nasal wall is visualization of the sites of olfactory neuro- distinguished from the smooth surface of the blastoma; the boundaries of the nasopharynx nasal septum by its “scroll-shaped” superior, and its distinction from the nasal cavity mark middle, and inferior turbinates. The small su- the interface of endodermally and ectodermally perior turbinate and larger middle turbinate are derived tissues, a critical watershed in neoplasm distribution. Angiofibromas and so-called lym- phoepitheliomas, for example, almost exclu- sively arise on the nasopharyngeal side of this line, whereas schneiderian papillomas, lobular capillary hemangiomas, and sinonasal intesti- nal-type adenocarcinomas almost entirely arise anterior to the line, in the nasal cavity. -
Palatoglossus Muscle Stimulation for Treatment of Obstructive Sleep Apnea
Palatoglossus Muscle Stimulation for Treatment of Obstructive Sleep Apnea Summary A Vanderbilt researcher has developed a device to stimulate the palatoglossus muscle in order to treat sleep apnea. This has the potential to treat patients who have failed to succeed with current sleep apnea treatments. Addressed Need Hypoglossal nerve stimulation (HNS) has been established as an effective form of treatment for patients with obstructive sleep apnea who cannot tolerate positive airway pressure. HNS works by stiffening the tongue muscles to increase pharyngeal airway size. However, patients with significant retropalatal airway collapse are not candidates for HNS offered in the US. This new treatment would provide these patients with an alternative therapy method to combat sleep apnea. Unique Features Electrical stimulation of the nerve to the palatoglossus muscle Potential to dilate retropalatal space and reduce obstructive sleep apnea Can treat patients who may be unsuccessful with other sleep apnea treatments Technology Description The palatoglossus muscle forms the anterior tonsillar pillar. It approximates the tongue and soft palate, sealing off the oral cavity and dilating the retropalatal space. This muscle is innervated by branches of the pharyngeal plexus and functions independently of the hypoglossal nerve innervating the remaining tongue musculature. Electrical stimulation of the nerve to the palatoglossus muscle has the potential to dilate the retropalatal space and reduce the burden of obstructive sleep apnea. Technology Development Status The treatment process has been designed, and physiological studies are pending. Cadaveric studies are being completed to evaluate the accessibility of the palatoglossus muscle through the neck. Intellectual Property Status A patent application has been filed. -
Olfactory Dysfunction
Olfactory Dysfunction: By Steven Sobol, MD, MSc; Saul Frenkiel, MD, FRCSC; and Debbie Mouadeb he sense of smell plays an important role in protecting Tman from environmental dangers, such as fire, natural gas leaks and spoiled food. Physiologically, the chemical senses aid in normal digestion by triggering gastrointestinal secretions.1 Smell influences the palatability of food. Defects in the sense of smell are associated with alterations in perceptions of flavor, leading to anorexia and weight loss. Psychologically, smell is powerful in establishing strong positive and negative memories, and affects socialization and interpersonal relationships. Smell dysfunctions often mean considerable disability and a lower quality of life. Loss or decreased olfactory function affects approximately one per cent of Americans under the age of 60 and more than half the population over that age.2 Aside from having a substantial impact on an individual’s quality of life, olfactory dysfunction may signal an underlying disease. Smell disorders have been largely overlooked by the medical community because of a lack of knowledge and understanding of the sense of smell and its disease states, as well its diagnosis and management. Patients with olfactory disorders need to be clinically assessed, and the etiology and anatomical location of their disorder should be sought out. The Canadian Journal of Diagnosis / August 2002 55 Olfactory Dysfunction Summary What are the causes of olfactory dysfunction? 1.Conductive olfactory loss is any process that causes sufficient obstruction in the nose preventing odorant molecules from reaching the olfactory epithelium. 2.Sensorineural olfactory loss is any process that directly affects and impairs either the olfactory epithelium or the central olfactory pathways. -
Anatomy and Physiology of the Velopharyngeal Mechanism
Anatomy and Physiology of the Velopharyngeal Mechanism Jamie L. Perry, Ph.D.1 ABSTRACT Understanding the normal anatomy and physiology of the velopharyngeal mechanism is the first step in providing appropriate diagnosis and treatment for children born with cleft lip and palate. The velopharyngeal mechanism consists of a muscular valve that extends from the posterior surface of the hard palate (roof of mouth) to the posterior pharyngeal wall and includes the velum (soft palate), lateral pharyngeal walls (sides of the throat), and the posterior pharyngeal wall (back wall of the throat). The function of the velopharyngeal mechanism is to create a tight seal between the velum and pharyngeal walls to separate the oral and nasal cavities for various purposes, including speech. Velopharyngeal closure is accomplished through the contraction of several velopharyngeal muscles including the levator veli palatini, musculus uvulae, superior pharyngeal con- strictor, palatopharyngeus, palatoglossus, and salpingopharyngeus. The tensor veli palatini is thought to be responsible for eustachian tube function. KEYWORDS: Anatomy, physiology, velopharyngeal muscles, cleft palate anatomy Downloaded by: SASLHA. Copyrighted material. Learning Outcomes: As a result of this activity, the reader will be able to (1) list the major muscles of the velopharyngeal mechanism and discuss their functions; (2) list the sensory and motor innervation patterns for the muscles of the velopharyngeal mechanism; and (3) discuss the variations in velopharyngeal anatomy found in an unrepaired cleft palate. Understanding the normal anatomy and and treatment for children born with cleft lip physiology of the velopharyngeal mechanism is and palate. Most of the diagnostic and therapy the first step in providing appropriate diagnosis approaches are based on a strong foundation of 1Department of Communication Sciences and Disorders, Guest Editor, Ann W. -
Respiratory System
Respiratory system By: Dr. Raja Ali Overview of Respiratory System: Nasal Cavity: Vestibule of the Nasal Cavity. Respiratory Region of the Nasal Cavity . Olfactory Region of the Nasal Cavity . Paranasal Sinuses . Pharynx. Larynx. Trachea . Mucosa. Submucosa. Fibrocartiligenous coat. Advantitia. Bronchi. Bronchioles. Bronchiolar Structure . Aleveoli. Blood Supply . Lymphatic Vessels . Nerves . ● T e structures which are responsible for the inhalation of air, exchange of gases between the air and blood and exhalation of carbon dioxide constitute the respiratory system. ● Apart from respiration, this system is also responsible for olfaction and sound production. ● T e respiratory system consists of two parts—a conducting part (which carries air) and a respiratory part (where gas exchange takes place). ● T e conducting part consists of nasal cavity, paranasal sinuses, nasopharynx, larynx, trachea, bronchi, bronchioles and terminal bronchioles . ● T e respiratory part consists of respiratory bronchioles, alveolar ducts, alveolar sacs and alveoli. GENERAL STRUCTURE OF THE CONDUCTING PORTION OF THE RESPIRATORY TRACT _ In general, the respiratory tract is made of four coats (Fig. 16.2), namely, 1. Mucosa _ It includes the epithelial lining and the underlying lamina propria. The epithelium is usually pseudostratifi ed ciliated columnar epithelium with goblet cells. 2. Submucosa _ It is a layer of loose connective tissue containing mixed glands. 3. Cartilage layer _ This layer is mostly formed by hyaline cartilage plus smooth muscle. 4. Adventitia _ It is a layer of fi broelastic connective tissue merging with the surrounding STRUCTURAL CHANGES IN THE CONDUCTING PORTION OF THE RESPIRATORY TRACT (FROM LARYNX TO BRONCHIOLE) _ The epithelium gradually decreases in thickness (from pseudostratifi ed columnar ciliated to simple cuboidal ciliated). -
The Olfactory Mucosa of the Sheep
THE OLFACTORY MUCOSA OF THE SHEEP By JEAN E. KRATZING* [Manuscript received July 7, 1969] Summary The olfactory mucosa of the sheep was studied by light and electron micro scopy. The epithelium conforms to the general vertebrate pattern and consists of olfactory receptor cells, supporting, and basal cells. The free edge of the epithelium is made up of long microvilli from the supporting cells and olfactory rods of the receptor cells, each carrying 40-50 cilia. All cell types contain large dark granules which may be the site of olfactory pigment. The basement membrane is not visible in light microscopy and is fine and discontinuous in electron microscopy. Bowman's glands are simple, tubular, mucus-secreting glands in the lamina propria. Their cells contain basal granules resembling those in the epithelial cells. The lamina propria also contains bundles of fine, unmyelinated, olfactory nerve fibres which are the proximal continuations of the receptor cells. 1. INTRODUCTION Schultze, in 1856, was the first to establish that the olfactory epithelium consisted of three types of cells: sensory, supporting, and basal. The sensory cells are unusual in that they retain their primitive position on the surface of the body, but extend their proximal portions as olfactory nerve fibres to the glomerular zone of the olfactory bulb. The finer details of olfactory membrane structure have come under scrutiny with the electron microscope mainly as a result of renewed interest in the nature of the olfactory process. Moulton and Beidler (1967) give a comprehensive review of recent findings on structure and function. Nevertheless, considerable gaps remain in our knowledge, especially in the detailed structure of the membrane in the domesticated ruminants.