Induction of Therapeutic Tissue Tolerance Foxp3 Expression Is

Home , ANKRD24, BMPR1B, CCDC130, CDC25C, Centromere protein B, Dipeptidase 2

Foxp3 Expression Is Required for the Induction of Therapeutic Tissue Tolerance Frederico S. Regateiro, Ye Chen, Adrian R. Kendal, Robert Hilbrands, Elizabeth Adams, Stephen P. Cobbold, Jianbo This information is current as Ma, Kristian G. Andersen, Alexander G. Betz, Mindy of September 30, 2021. Zhang, Shruti Madhiwalla, Bruce Roberts, Herman Waldmann, Kathleen F. Nolan and Duncan Howie J Immunol published online 17 September 2012

http://www.jimmunol.org/content/early/2012/09/17/jimmun Downloaded from ol.1200449

Supplementary http://www.jimmunol.org/content/suppl/2012/09/17/jimmunol.120044 Material 9.DC1 http://www.jimmunol.org/

Why The JI? Submit online.

• Rapid Reviews! 30 days* from submission to initial decision

• No Triage! Every submission reviewed by practicing scientists

by guest on September 30, 2021 • Fast Publication! 4 weeks from acceptance to publication

*average

Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts

The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2012 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Published September 17, 2012, doi:10.4049/jimmunol.1200449 The Journal of Immunology

Foxp3 Expression Is Required for the Induction of Therapeutic Tissue Tolerance

Frederico S. Regateiro,*,1 Ye Chen,*,1 Adrian R. Kendal,* Robert Hilbrands,* Elizabeth Adams,* Stephen P. Cobbold,* Jianbo Ma,* Kristian G. Andersen,† Alexander G. Betz,‡ Mindy Zhang,x Shruti Madhiwalla,x Bruce Roberts,x Herman Waldmann,*,2 Kathleen F. Nolan,*,2 and Duncan Howie*,2

CD4+Foxp3+ regulatory T cells (Treg) are essential for immune homeostasis and maintenance of self-tolerance. They are produced in the thymus and also generated de novo in the periphery in a TGF-b–dependent manner. Foxp3+ Treg are also required to achieve tolerance to transplanted tissues when induced by coreceptor or costimulation blockade. Using TCR-transgenic mice to

avoid issues of autoimmune pathology, we show that Foxp3 expression is both necessary and sufficient for tissue tolerance by Downloaded from coreceptor blockade. Moreover, the known need in tolerance induction for TGF-b signaling to T cells can wholly be explained by its role in induction of Foxp3, as such signaling proved dispensable for the suppressive process. We analyzed the relative contribution of TGF-b and Foxp3 to the transcriptome of TGF-b–induced Treg and showed that TGF-b elicited a large set of downregulated signature genes. The number of genes uniquely modulated due to the influence of Foxp3 alone was surprisingly limited. Retroviral-mediated conditional nuclear expression of Foxp3 proved sufficient to confer transplant-suppressive potency + b on CD4 T cells and was lost once nuclear Foxp3 expression was extinguished. These data support a dual role for TGF- and http://www.jimmunol.org/ Foxp3 in induced tolerance, in which TGF-b stimulates Foxp3 expression, for which sustained expression is then associated with acquisition of tolerance. The Journal of Immunology, 2012, 189: 000–000.

mmune homeostasis and maintenance of self-tolerance pression. Short-term coreceptor blockade provided the first dem- depends upon constant vigilance by CD4+Foxp3+ regula- onstration that induction of tolerance could be achieved using low- I tory T cells (Treg). Commitment to the Treg lineage occurs impact intervention in a mature immune system (7). Studied in primarily in the thymus (1, 2), but also in the periphery in a TGF- a transplantation setting, this form of tolerance is totally depen- b–dependent manner (3–6). One of the major goals of modern dent on the ability of TGF-b to signal to T cells (6) and is also by guest on September 30, 2021 immunosuppression, be it in autoimmune disease or transplanta- associated with de novo induction of Ag specific Foxp3+ induced tion, is to harness tolerance mechanisms such as those used by Treg (iTreg) (4, 8). This raises the possibility that the absolute Treg to minimize the duration and extent of drug immunosup- need for TGF-b is simply to guarantee conversion of naive CD4+ T cells to stable Foxp3 expression. However, TGF-b signaling not only induces expression of *Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, Foxp3, but also many other effector molecules, including CD39, United Kingdom; †Faculty of Arts and Sciences Center for Systems Biology, Harvard CD73, CTLA4, CD103, neuropilin, perforin, and IL-10 (9–12). University, Cambridge, MA 02138; ‡Medical Research Council Laboratory of Mo- lecular Biology, Cambridge CB2 0QH, United Kingdom; and xGenzyme Corporation, There are also claims that TGF-b is needed for the effector arm of Framingham, MA 01701 suppression (13), and if so, this, too, could explain the need for 1F.S.R. and Y.C. are cofirst authors. TGF-b signaling to T cells. + 2H.W., K.F.N., and D.H. are cosenior authors. Despite a large literature on Foxp3 Treg in self-tolerance, it Received for publication February 3, 2012. Accepted for publication August 15, is not known whether Foxp3 expression is essential for domi- 2012. nant tolerance induced to foreign Ags or whether other genetic/ This work was supported by a program grant from the Medical Research Council and expression modalities (e.g., those potentially necessary for Th3, the European Framework 7 Betacell program. Tr1, and iTr35 cells) can operate in its absence. Using a combi- The microarray data presented in this article have been submitted to the National nation of genetically manipulated mouse strains unable to express Center for Biotechnology Information’s Gene Expression Omnibus (http://www.ncbi. Foxp3, retroviral constructs facilitating conditional nuclear lo- nlm.nih.gov/geo/) under accession number GSE39529. calization of Foxp3, and a dominant-negative TGF-bRII to ablate Address correspondence and reprint requests to Dr. Duncan Howie and Dr. Herman Waldmann, Sir William Dunn School of Pathology, Oxford University, South Parks TGF-b signaling in T cells, we have addressed the contributions of Road, Oxford OX1 3RE, U.K. E-mail addresses: [email protected] TGF-b and Foxp3 to the induction and function of iTreg. We show (D.H.) and [email protected] (H.W.) that Foxp3 expression is indispensible for tolerance induction to The online version of this article contains supplemental material. transplanted tissue, and its continued nuclear expression is nec- Abbreviations used in this article: B6, C57BL/6J; BMDC, bone marrow-derived essary for maintenance of tolerance. In contrast, once tolerance is dendritic cell; CBA, CBA/Ca; cTreg, conditional regulatory T cell; hCD2, human CD2; 4HT, 49hydroxytamoxifen; HY, Marilyn T cell untreated with TGF-b;HYAb, established, prevention of tissue damage does not depend on TGF- peptide of male Ag Dby (NAGFNSNRANSSRSS); HYT, Marilyn T cell treated with b signaling to naive T cells. This indicates that the major role of 2/2 TGF-b; iTreg, induced regulatory T cell; Marilyn, Marilyn.Rag1 ; nTreg, natural TGF-b in this form of acquired tolerance largely resides in the regulatory T cell; Treg, regulatory T cell. induction of Foxp3 expression in naive CD4+ T cells. Comparative Copyright Ó 2012 by The American Association of Immunologists, Inc. 0022-1767/12/$16.00 transcriptome analysis of in vitro-generated, TGF-b–experienced

www.jimmunol.org/cgi/doi/10.4049/jimmunol.1200449 2 Foxp3 AND TGF-b IN ACQUIRED TOLERANCE

2 Foxp3+ and Foxp3 CD4+ T cells with TGF-b–experienced performed using a commercial kit (eBioscience) according to the manu- Foxp32/2 CD4+ T cells not only confirms TGF-b signaling in all facturer’s directions. the populations, but also demonstrates that, although crucial for MoFlo FACS sorting of cells maintenance of tolerance, the proportion of the transcriptome controlled specifically by Foxp3 in iTreg appears to be relatively Flow cytometry sorting was performed using a MoFlo sorter (DakoCyto- mation). limited. Production of conditional Foxp3 retroviral supernatant Materials and Methods All vectors used except pCL-ECO have previously been described (18). The Experimental animals conditional Foxp3 construct cFoxp3 was made by cloning sequence- encoding ERT2, a modified estrogen-binding domain, in-frame with the CBA/Ca (CBA), C57BL/6J (B6), CBA.Rag12/2, B6.Rag12/2, Marilyn. 2/2 2/2 C terminus of Foxp3. GFP coding sequence was cloned directly after the Rag1 (Marilyn) [derived from Marilyn.Rag2 (14)], Marilyn. fifth codon of Foxp3 to produce the fusion protein GFP-Foxp-ERT2. This Foxp3hCD2 (8), Marilyn.Foxp32/2 (9), CD4-dnTGFbRII (15), CD4- 2/2 2/2 was then cloned into a Moloney murine leukemia virus backbone, a cir- dnTGFbRII.Rag1 , and Marilyn.CD4-dnTGFbRII.Rag1 mice were cular plasmid that also contained a GPI-linked and internal ribosome entry bred and maintained under specific pathogen-free conditions at the Sir site-driven rat CD8a (rCD8) gene. The empty control vector contained William Dunn School of Pathology (University of Oxford, Oxford, U.K.). only the GFP and rCD8 segments, but no Foxp3. The packaging vector, . CD4-dnTGFbRII mice backcrossed to B6 for 10 generations were pCL-ECO, was purchased from Addgene (Cambridge, MA). The day be- crossed with B6.Rag12/2 mice for two generations to generate CD4- 2 2 fore transfection, a confluent plate of HEK 293eT cells were split at one in dnTGFbRII.Rag1 / animals, which were further crossed with Marilyn ∼ b three and plated in six-well plates at 40% confluency, with 2 ml/well. mice to introduce the Dby-H2A specific TCR-transgenic element. All Approximately 16 h later, the cells were transfected with 2 mg pCL-ECO

experimental procedures received local ethics committee approval and Downloaded from packaging plasmid and 2 mg retroviral vector cFoxp3 using the CaCl2 were conducted in accordance with the Home Office Animals (Scientific method. Six hours after transfection, the medium in the well was replaced Procedures) Act of 1986. with fresh medium. A further 24 h later, the viral supernatant was har- Skin grafting vested and filtered through a 0.45-mm filter. Protamine sulfate (600 mg/ml) was added to the viral supernatant. Skin grafting was performed as described previously (16). Maintenance of + nuclear Foxp3 in cFoxp3-transduced T cells adoptively transferred into Retroviral transduction of CD4 T cells mice was enforced by daily i.p. injections of tamoxifen in sunflower oil (1 + 3 5 AutoMACS-sorted CD4 cells were cultured at 2 10 /well in a 96-well http://www.jimmunol.org/ mg daily). plate precoated with anti-CD3 (KT3; 4 mg/ml in PBS, 1 h at 37˚C). The Abs cells were activated for 24 h and then resuspended in a 1:2 mixture of viral supernatant and complete medium (IMDM containing 10% v/v FCS and Anti-CD4 (L3T4), anti-CD25 (7D4), and anti-CTLA4 (BN13) were pur- 10 mM 2-ME). This mix was supplemented with 5 ng/ml recombinant chased from BD Biosciences. Anti-Foxp3 (FJK-16s), anti-CD39 (24DMS1), murine IL-2 (PeproTech) and 5 ng/ml recombinant murine IL-7 (Pepro- and anti-CD73 (TY/11.8) were purchased from eBioscience. Anti-GITR Tech). This was followed by centrifugation at 500 3 g for 2 h at 32˚C. (YGITR-765) was purchased from Serotec. Cells were analyzed 40 h later. Typical transduction efficiencies were 30– 50%. Following transduction, in most experiments, the cells were MoFlo Cytokines for cell culture and synthetic peptides sorted (DakoCytomation) to achieve 99.9% GFP-positive cells, as indicated in figure legends. For induction of nuclear localization of Foxp3, Lyophilized recombinant human TGF-b1 was purchased from R&D Sys- transduced cells were cultured in the presence of 50 nM of 49hydroxy- by guest on September 30, 2021 tems and reconstituted to 10 mg/ml in 4 mM HCl containing 1 mg/ml BSA. tamoxifen (4HT) for at least 24 h. Lyophilized peptide HYAb (NAGFNSNRANSSRSS) (14) was reconstituted in PBS and used at a maximum working concentration of 100 nM. Confocal microscopy Bone marrow-derived dendritic cell preparation Confocal microscopy was performed on a Zeiss LSM 510 META laser scanning microscope (Carl Zeiss MicroImaging, Go¨ttingen, Germany) Bone marrow-derived dendritic cells (BMDCs) were prepared as described using a 320 objective. previously (17). Murine GM-CSF–enriched supernatant was harvested from the transfected cell line X63 (provided by D. Gray, Edinburgh, Cytokine measurement Scotland) and used at an equivalent of 5 ng/ml. A 23-component multiplex bead-based assay specific for eotaxin, G-CSF, CD4+ T cell preparation GM-CSF, IFN-g, IL-1a, IL-1b, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p40, IL-12p70, IL-13, IL-17, eotaxin, keratinocyte chemoattractant, Splenic CBA or B6 CD4+ T cells were isolated by negative selection using + MCP-1, MIP-1a, MIP-1b, RANTES, and TNF-a (Bio-Rad) was used an AutoMACS CD4 T cell isolation kit and AutoMACS separator (Mil- according to the manufacturer’s recommended protocol and samples an- tenyi Biotec). alyzed using a Bio-Plex System and Bio-Plex Manager Software 4.0 (Bio- In vitro generation of iTreg Rad). RBC-depleted splenocytes from Marilyn, Marilyn.Foxp3hCD2, and Marilyn. Proliferation and suppression assays 2/2 Foxp3 mice were cultured at a 5:1 ratio with mitomycin-treated B6 + b Effector cells were Marilyn CD4 cells enriched by negative selection female BMDCs in RPMI 1640 containing 100 nm HYA peptide for 7 d. + For TGF-b–conditioned iTreg cultures, recombinant human TGF-b was using AutoMACS. Suppressor cells were Marilyn CD4 cells that had been also added at 2 ng/ml. Foxp3 expression was typically 50–90% for TGF- transduced with retroviral vectors for 40 h and then sorted based on CD4 b–conditioned cultures (i.e., 50–90% of TGF-b–conditioned cultures were and GFP expression. BMDCs were prepared from female B6 mice. Sup- + m Foxp3 iTregs). For microarray analysis, MoFlo sorting (DakoCytomation, pressor cells and BMDCs were incubated with mitomycin C (25 g/ml) for + 30 min at 37˚C and washed three times before being added to the assay. Glostrup, Denmark) was employed to sort Foxp3 and negative cells from 3 4 3 4 the cultures based on human CD2 (hCD2) expression. Each well of a 96-well plate contained 1 10 BMDCs, 2 10 sup- pressors, and 2.5 3 104 effectors. HYAb peptide was added as a dilution FACS series (100, 10, 1, and 0 nM). Cultures were incubated for 72 h. To measure proliferation, [3H]thymidine (GE Healthcare) was added (0.5 Cells were washed twice in PBS containing 0.5% w/v BSA and incubated mCi/well) for the final 18 h of culture. [3H]thymidine incorporation was for 10 min at room temperature in PBS with 10 mg/ml anti-FcR block then measured by scintillation counting. (2.4G2) and then with primary Ab for 30 min in the dark at 4˚C. Following washing and fixation with 2% paraformaldehyde, analysis was performed Affymetrix gene expression profiling of total RNA using on an FACSCalibur (BD Biosciences) with dual laser excitation (488 and whole-transcript assay and gene/exon 1.0 ST arrays 633 nm). Data acquisition was performed with interchannel compensation using CellQuest version 3.1 software (BD Biosciences) and data analysis Cultured splenocytes were used to generate highly purified populations of performed with FlowJo 7.2.4 software (Tree Star). Foxp3 staining was Marilyn.Foxp3hCD2-activated (HY) and TGF-b–induced (HYT) cells sor- The Journal of Immunology 3

ted as CD4+hCD2+ and CD4+hCD22 and Marilyn.Foxp32/2 HY and HYT cells sorted as CD4+. Three to five independent biological replicates of the five sorted cell populations above were processed (RNA isolation, labeling, and hybridization to mouse exon 1.0 ST Affymetrix arrays; Affymetrix) by Asuragen (Austin, TX). Total RNA was isolated from frozen cell pellets by Asuragen according to the company’s standard operating procedure for automated isolation on a KingFisher magnetic particle separator (Thermo Scientific). The procedure included a DNAse treatment step and cleanup prior to elution from the magnetic beads. The purity and quantity of total RNA samples were determined by absorbance readings at 260 and 280 nm using a NanoDrop ND-1000 UV spectro- photometer (NanoDrop). The integrity of total RNA was qualified by Agilent Bioanalyzer 2100 microfluidic electrophoresis using the Nano Assay (Agilent Technologies). Samples for mRNA profiling studies were processed by Asuragen according to the company’s standard operating procedures. Biotin-labeled sense-strand cDNA was prepared from 30 mg cRNA generated from either 500 ng or 1 mg total RNA per sample using a modified Affymetrix Gen- eChip Whole Transcript Sense Target Labeling Assay (Affymetrix). Inter- mediate cRNA and resulting cDNA yields were quantified by spectropho- tometry. Fragmentation and labeling of cDNA was performed using 5 mg for exon arrays. Hybridization to arrays was carried out at 45˚C for 16 h

in an Affymetrix Model 640 hybridization oven (Affymetrix). Arrays were Downloaded from washed and stained on an Affymetrix FS450 Fluidics station (Affymetrix). The arrays were scanned on an Affymetrix GeneChip Scanner 3000 7G (Affymetrix). For every array scanned, .DAT, .CEL, .jpg, and .xml flat files were provided. Data generated from Asuragen for the arrays were further preprocessed in the Affymetrix Expression Console software version 1.2 (Affymetrix), which was used to normalize .CEL files using the quantile normalization method, and the data were summarized at both the exon and gene level by using the robust multichip analysis algorithm. All further http://www.jimmunol.org/ data analysis was performed in JMP Genomics software version 5.1 (JMP) using the gene level log2 data. Low-value intensities were filtered out. Differential gene expression analysis was performed on transcript values based on core probe sets. The microarray data discussed in this publication have been deposited in the National Center for Biotechnology Informa- tion’s Gene Expression Omnibus and are accessible through Gene Ex- pression Omnibus Series accession number GSE39529 (http://www.ncbi. nlm.nih.gov/geo/query/acc.cgi?acc=GSE39529).

Statistical analysis by guest on September 30, 2021 Statistical signiﬁcance was determined using one-way ANOVA tests with Dunnett’s multiple comparison posttest or Student t test (unpaired, two- tailed) using GraphPad Prism software (http://www.graphpad.com; GraphPad). In the ﬁgures, *p , 0.05, **p , 0.01, and ***p , 0.001.

Results Foxp3 expression is required for induction of transplantation tolerance mediated by coreceptor blockade It is well established that T cells expressing Foxp3 are critical for maintenance of tolerance to self-Ags. The requirement for Foxp3 in the induction of peripheral tolerance to foreign Ags has not, FIGURE 1. The relative requirements for Foxp3 and TGF-b in induced however, been unequivocally demonstrated. It is possible that tolerance to foreign Ag. (A) Female Marilyn mice (n = 13) were trans- other cell types such as Th3, Tr1, or iTr35 might emerge and planted with male B6.Rag2/2 skin and treated with 1 mg of YTS177 (anti- operate in its absence. Transplantation tolerance can be induced CD4 blocking Ab) at days 0, 3, and 5 after grafting. Identical grafting and treatment was performed using female Marilyn.Foxp32/2 mice (n = 11) and the grafts monitored for rejection (log-rank p value , 0.0001). Data are representative of two separate experiments. (B) Marilyn and Marilyn. was titrated and is shown compared with the injection of 1 3 106 Marilyn Foxp32/2 splenocytes were cultured for 7 d with female B6 BMDC and HYT cells (dark circles). (E) Female Marilyn mice made tolerant to male HYAb peptide in the absence (HY) or presence (HYT) of TGF-b. Histo- B6.Rag2/2 skin by anti-CD4 Ab treatment (1 mg at days 0, 3, and 5 after paque-purified cells were costained with CD4 and Foxp3, CD73, or CD103 grafting) were transplanted with a second male B6.Rag2/2 skin graft 95– as shown. Numbers represent percentage of cells in the indicated quadrant. 120 d after the first. At the time of the second graft, the mice also received Data are representative of two separate experiments. (C) Marilyn or 1 3 106 AutoMACS-purified CD4+ T cells from female Marilyn or female Marilyn.Foxp32/2 splenocytes were stimulated in vitro for 7 d with female Marilyn.dnTGFbRII mice, and rejection was monitored daily. The rejec- B6 BMDCs and HYAb peptide in the absence (HY) or in the presence tion competency of the transferred Marilyn and Marilyn.dnTGFbRII (HYT) of TGF-b. One million Ficoll-purified live cells were injected into T cells was validated by demonstrating the capacity of 1 3 106 cells female B6.Rag2/2 mice, and 1 d later, the mice were transplanted with transferred into naive female Rag2/2 recipients to reject male Rag2/2 skin a male B6.Rag2/2 skin graft. Rejection was monitored daily. Data are grafts. The x-axis represents days after grafting primary grafts for the re- representative of two separate experiments. (D) Using a similar experi- jection controls and days after second grafting for assessing the require- mental setting, the number of Marilyn.Foxp32/2 HYT splenocytes injected ment for intact TGF-b signaling in mediating dominant tolerance. 4 Foxp3 AND TGF-b IN ACQUIRED TOLERANCE in TCR-transgenic mice lacking natural Treg (nTreg). This is few as 2500 Marilyn T cells were sufficient to reject male grafts associated with the development of Foxp3+ iTreg in the pe- on adoptive transfer into Rag2/2 recipients. One million Marilyn riphery. It cannot be induced, however, if TGF-b signaling to or Marilyn.Foxp32/2 HY or HYT splenocytes were injected into T cells is prevented (6). We asked if alternative routes to tol- female B6.Rag2/2 recipients, followed by grafting with male B6. erance might engage in a situation in which Foxp3 induction was Rag2/2 skin. All seven mice that received TGF-b–experienced prevented by genetic ablation, but in which TGF-b signaling Foxp3-sufficient splenocytes accepted their grafts, despite co- pathways were left intact. To address this in circumstances in transfer of .30 times more Foxp32 cells than should be necessary which autoimmune pathology could be avoided, we generated for rejection (Fig. 1C). Mice that received either Ag-activated or Foxp3 2/2 Marilyn TCR-transgenic mice. All of the T cells in Ag-activated and TGF-b–experienced splenocytes from Foxp32/2 normal Marilyn mice are monospecific. They recognize a spe- animals rejected their grafts within the same rapid time frame cific peptide of the male Ag Dby (HYAb) presented in the as that of wild-type Ag-activated but non–TGF-b–experienced context of H2-Ab, and naive T cells do not express Foxp3. Fe- (Foxp3-negative) splenocytes (Fig. 1C). Even as few as 4 3 104 male Marilyn and Marilyn.Foxp32/2 mice were each grafted HYT Marilyn.Foxp32/2 cells were still able to reject male skin with male B6.Rag2/2 skin under the influence of a short regi- grafts at the same rate as 1 3 106 cells (Fig. 1D). In short, TGF-b men of anti-CD4–blocking Ab previously shown to be sufficient conditioning in the absence of Foxp3 expression has little impact to generate tolerance and the induction of peripheral Foxp3+ on the ability of the T cells to reject grafts, showing the critical iTreg in Marilyn mice (8). As expected, the majority of the role of Foxp3 in extinguishing that function and thus ruling out Foxp3-sufficient mice accepted their male grafts indefinitely, a major role for alternative TGF-b–induced pathways [such as 2 2 whereas all of the Marilyn.Foxp3 / mice had rejected their adenosine generation (9)] in iTreg-induced long-term graft ac- Downloaded from grafts by 60 d (Fig. 1A). Thus, the tolerance induced by short- ceptance in this setting. term coreceptor blockade requires a functional Foxp3 gene, ThetrueroleforTGF-b in Treg-mediated suppression is despite an intact TGF-b signaling axis. controversial, with studies arguing for and against its requirement. We have previously shown that TGF-b signaling to T cells TGF-b–driven in vitro-generated iTreg require Foxp3 is essential for the development of dominant tolerance (6). To expression to become rejection incompetent

establish whether in this case TGF-b was operating in the in- http://www.jimmunol.org/ TGF-b induces potent anti-inflammatory adenosine production by ductive phase of tolerance or at a later stage to sustain dominant + CD4 T cells via cell-surface–expressed CD39 and CD73 ecto- tolerance, female Marilyn mice were made tolerant to male B6. nucleotidase activity (9). Regulation of these enzymes is inde- Rag2/2 skin using anti-CD4 Ab treatment. On regrafting at 95– pendent of Foxp3 expression, and it has been suggested may 120 d after the first graft, the tolerized mice also received 1 3 confer suppressive activity in the absence of Foxp3 (19). We asked 106 rejection-competent CD4+ T cells from either female whether TGF-b–conditioned T cells might still be able to suppress Marilyn or female Marilyn.dnTGFbRII mice. In both cases, the rejection of grafts if they could not express Foxp3 and also mice were able to resist rejection by the transferred cells (Fig. whether TGF-b was required as a mechanism of suppression. We 1E), demonstrating that TGF-b signaling to T cells was not es- generated sets of TGF-b–conditioned T cells in vitro by stimu- sential for suppression of rejection once regulatory T cells had by guest on September 30, 2021 2/2 lating Marilyn or Marilyn.Foxp3 splenocytes with BMDCs been induced. and cognate peptide in the absence (HY) or presence (HYT) of + + TGF-b. These cultures typically yielded ∼70% Foxp3+ cells in the CD4 T cells that fail to convert to Foxp3 in the presence of b Foxp3-sufficient cells after 7 d (Fig. 1B). CD4+ T cells from both TGF- remain able to secrete proinflammatory cytokines wild-type and Foxp32/2 animals upregulated CD73 and CD103, We then asked what had become of CD4+ T cells that had not indicating effective TGF-b signaling, consistent with their ex- converted to Foxp3 expression by comparing their pattern of pression of equivalent surface levels of TGF-bRII (Supplemental cytokine secretion to that of their Foxp3+ counterparts. Mari- Fig. 1A). Previous data (Supplemental Fig. 1B) indicated that as lyn.Foxp3hCD2 CD4+ T cells were activated for 7 d with den-

FIGURE 2. T cells failing to express Foxp3 after exposure to TGF-b secrete proinﬂammatory cytokines. Marilyn.Foxp3hCD2 splenocytes were cultured in the presence of C57BL/6 female BMDCs and HY peptide in the presence of 10 ng/ml TGF-b for 7 d. TGF-b–treated cells were then sorted as those that converted to Foxp3 expression, CD4+hCD2+, and those that remained Foxp3 negative, CD4+hCD22. Sorted cells were stimulated with anti-CD3/anti-CD28 beads for 48 h prior to assay of cytokines in the cell- culture supernatant. Data represent means 6 SEM of triplicate cultures. Results are representative of two separate experiments. Statistical signiﬁcance measured by unpaired t test: *p # 0.05, **p # 0.005, ***p # 0.0005. The Journal of Immunology 5

dritic cells and HY peptide in the presence of TGF-b. Cells sorted into hCD2-positive and -negative populations were then stimulated for 2 d with anti-CD3/anti-CD28–conjugated beads. Culture supernatants were assayed for cytokine content. T cells that had not transcribed Foxp3 in response to TGF-b exposure produced 5–20-fold increased amounts of ILs 2, 3, 4, 5, 6, 13, and 17 and IFN-g (Fig. 2). Thus, in the absence of Foxp3, TGF-b–treated cells are clearly capable of producing proin- ﬂammatory cytokines commensurate with their capacity to reject grafts. TGF-b and Foxp3 induce independent and distinct transcriptional signatures As TGF-b–induced Foxp3 expression is crucial to the continuing function of iTreg in vivo and so closely linked to the biology of induced tolerance, we asked to what extent the gene transcription program induced by TGF-b was related to Foxp3 expression. To answer this question, we performed microarray analysis com- + hCD2 paring transcriptomes of CD4 T cells from Marilyn.Foxp3 Downloaded from or Marilyn.Foxp32/2 mice treated (HYT) or untreated (HY) with TGF-b in vitro (see Materials and Methods). In each case, CD4+ cells were MoFlo sorted (DakoCytomation) and, in the case of the Marilyn.Foxp3hCD2-derived cells, sorted into Foxp3 expres- sors and nonexpressors on the basis of surface expression of

hCD2. http://www.jimmunol.org/ We asked whether the signature of transcripts regulated by TGF- b exposure in CD4+ T cells was dependent on Foxp3 expression. A global suppression effect was observed upon TGF-b treatment in cells of Marilyn.Foxp3hCD2 mice, identified by comparative analysis between TGF-b–treated Marilyn.Foxp3hCD2 cells (including both HYT hCD2+ and HYT hCD22 populations) and untreated HY cells (Fig. 3A). A total of 3046 transcripts were found differentially expressed at p , 0.01 (Supplemental Table I). 2/2 A similar analysis performed on Marilyn.Foxp3 cells indicated by guest on September 30, 2021 469 transcripts differentially expressed at p , 0.01 (Fig. 3B, Supplemental Table II). To examine if the presence of Foxp3 wild-type transcripts could generate additional response following TGF-b treatment, the expression profile of the TGF-b signature in Marilyn. Foxp3hCD2 mice was examined in Marilyn.Foxp32/2 mice (Fig. 3C). The high correlation (R2 = 0.61) suggested that there was not a significant additional detectable effect, positive or negative, from the genomic copies of Foxp3.Thus,theTGF-b signature seems to be independent of Foxp3. These data also show that loss of Foxp3 was not inhibiting TGF-b responsiveness of these cells. Samples of the TGF-b–treated and -untreated, sorted hCD2+ and hCD22 groups exhibited the expected relative level of Foxp3 transcript expression (Fig. 4A). To identify a TGF-b–induced Foxp3 effect between the two sorted, TGF-b–influenced groups (HYT hCD2+ and HYT hCD22), a comparative analysis was first carried out to identify transcripts differentially expressed between the two populations. A total of 183 transcripts (p , 0.01) were

FIGURE 3. The contribution of Foxp3 to the TGF-b–induced transcript signature is relatively small. (A) A TGF-b transcript signature derived from derived from Marilyn.Foxp32/2 mice stimulated under the same conditions Marilyn.Foxp3hCD2 mice cultured with HY peptide and dendritic cells and as in (A): TGF-b untreated (UT) versus treated (T) cells. See Supplemental stimulated with TGF-b. Data represent TGF-b–induced Foxp3+ hCD2+ (T- Table II for gene identities. Three biological replicates for each treatment pos) and cells treated with TGF-b in the same cultures that failed to ex- group are shown. (C) Correlation of TGF-b signatures between Marilyn. press Foxp3, hCD22 (T-neg) cells versus cells activated under the same Foxp3hCD2 and Marilyn.Foxp32/2 mice. The green line indicates an ideal conditions but minus TGF-b (UT). Heat map of the differential transcripts correlation. The red line indicates the actual correlation, R2 = 0.61. Scatter + hCD2 derived from t test between untreated cells and TGF-b–induced hCD2 and plot of log2 (fold change) of transcripts in unsorted Marilyn.Foxp3. hCD22. See Supplemental Table I for gene identities. Five biological CD4+ T cells treated with or without TGF-b (x-axis) and Foxp32/2 CD4+ replicates for each cell type are shown. (B) A TGF-b transcript signature T cells treated with or without TGF-b (y-axis). 6 Foxp3 AND TGF-b IN ACQUIRED TOLERANCE

Ectopic tamoxifen-mediated nuclear localization of Foxp3 imposes a suppressive phenotype onto naive T cells Our demonstration that Foxp3 was indispensible for tolerance induced by TGF-b led us to ask whether the need for Foxp3 expression in tolerance was transient or sustained. Many groups have demonstrated that ectopic expression of Foxp3 leads to suppressive function, and in vitro cre-lox deletion of Foxp3 has been shown to reverse the suppressive properties of Treg. How- ever, it is not known whether iTreg need to express Foxp3 for prolonged periods in order for tolerance to be maintained nor what effect turning off Foxp3 in vivo following tolerance induction would have. For example, Foxp3-influenced T cells may, over time, acquire suppressive features that are Foxp3 independent. We therefore asked two questions: namely, is prolonged Foxp3 expression needed for iTreg to remain rejection incompetent, and is continuous Foxp3 expression required for iTreg to retain their suppressive ability? To address these questions, we used a retroviral construct, cFoxp3, encoding a fusion protein GFP-Foxp-ERT2, for which entry to the nucleus, and therefore Downloaded from Foxp3 activity, requires addition of tamoxifen (18) (see Materials and Methods). We first established the ability of the construct to translocate to the nucleus following tamoxifen treatment and to induce attributes consistent with a Treg phenotype, namely anergy, upregulation of Treg cell-surface markers, and suppression of proinflammatory cytokine production (Fig. 6). We showed that http://www.jimmunol.org/ after 64 h, GFP-Foxp3 fusion protein had clearly translocated into the nuclei of .95% of transduced AutoMACS-sorted CD4+ splenocytes, FACS-sorted for GFP and treated with 4HT, but remained predominantly cytoplasmic in transduced but noninduced cells (Fig. 6A, 6B). Tamoxifen exposure rendered the T cells anergic (Fig. 6C) and was associated with upregulation of the Treg-associated surface markers CTLA4, CD25, and GITR (Fig. 6D). Foxp3 negatively regulates transcription of many cy- by guest on September 30, 2021 tokines (20, 21), and we found that 4HT-treated transduced T cells also secreted minimal quantities of proinflammatory cytokines, such as IL-1, IL-2, IFN-g, IL-4, IL-9, and IL-17, when compared with cells transduced with empty vector or with cFoxp3,but without 4HT treatment (Fig. 7). We term such transduced cells induced to exhibit a regulatory phenotype by using 4HT as conditional Treg (cTreg). FIGURE 4. Identification of a TGF-b–dependent Foxp3 gene signature. Persistent nuclear expression of Foxp3 is required for cTreg to (A) Foxp3 expression by non–TGF-b–treated, activated hCD22CD4+ remain rejection incompetent T cells from Marilyn.Foxp3hCD2 mice (UT), TGF-b–treated CD4+ T cells 2 We next tested whether, in the absence of exogenous addition of from Marilyn.Foxp3hCD2 mice which failed to express Foxp3, hCD2 + + TGF-b, tamoxifen exposure would suffice to render T cells unable (T_neg), and TGF-b–treated hCD2 (T_pos) CD4 T cells assessed by + microarray. Data from five biological replicates are shown. (B) Volcano to reject grafts. Naive Marilyn CD4 T cells, which do not express plot of differential genes between Foxp3-positive (T_pos) and -negative Foxp3, were transduced with cFoxp3; half were treated and half (T_neg) TGF-b–treated CD4+ T cells described in (A). (C) Heat map of untreated with 4HT for 2 d in vitro to induce nuclear localization statistically differential transcripts derived by t test between Marilyn. of the GFP-Foxp-ERT2 fusion protein. CD4+GFP+ cells (Fig. 8A) Foxp3hCD2 mice sorted on peptide and dendritic cell-stimulated TGF-b– were purified by FACS and 2 3 104 or 1 3 106 cells transferred induced hCD2+ (T-pos) and cells treated with TGF-b in the same cultures into female B6.Rag2/2 mice. These mice then each received a male 2 that failed to express Foxp3, hCD2 (T-neg) cells. The same transcripts in B6.Rag2/2 skin graft; half received daily tamoxifen injections, + activated CD4 T cells untreated with TGF-b (UT) are shown as a control. and the other half daily injections of vehicle for 28 d posttrans- See Supplemental Table III for the identities of individual genes. Data plant. All of the mice that received 4HT-facilitated cTreg but from five biological replicates are shown. without further tamoxifen injections rejected their grafts within 20 d (Fig. 8B). Mice that received either 2 3 104 or 1 3 106 transduced cells treated in vitro with 4HT and with further daily found differentially expressed (Fig. 4B, 4C, Supplemental Table injections of tamoxifen accepted their grafts up to and following III). Among them, a subset of 34 transcripts was then identified as cessation of the tamoxifen injections, but rejected their grafts 14– uniquely associated with the TGF-b–induced hCD2+ cells (Fig. 17 d following the last tamoxifen injection. Once the tamoxifen 4C, indicated in blue, orange, and turquoise). Finally, upon further injections ended the speed of rejection was similar to that expe- eliminating general TGF-b effects, 27 transcripts were considered rienced on transfer of cells with no tamoxifen. Thus, persistent to comprise a unique TGF-b–induced-Foxp3 signature (Fig. 5A, expression of nuclear Foxp3 was associated in vivo with T cells 5B). maintaining a rejection-impotent phenotype. The Journal of Immunology 7

FIGURE 5. The TGF-b–driven Foxp3-induced gene signature comprises 27 genes. (A) Venn diagram showing the relationship of TGF-b signatures of genes in Foxp3-positive and -negative populations. CD4+ T cells from Marilyn.Foxp3hCD2 mice, TGF-b– treated, peptide-activated, and subsequently FACS- sorted into hCD2+ and hCD22 groups, were compared with TGF-b– and peptide-stimulated Foxp32/2 CD4+ T cells. Batch effects were removed and t tests applied to identify differentially expressed transcripts Downloaded from between the hCD2+ and hCD22 groups. To identify a unique TGF-b–induced Foxp3 signature (purple circle), the differential transcripts were filtered: 1) to include only those with unique expression profiles in hCD2+ cells; and 2) to exclude transcripts of Foxp3- independent TGF-b signatures from Foxp32/2 cells. http://www.jimmunol.org/ Data are from five biological replicate samples. (B) Heat map of statistically significant Foxp3-specific TGF-b signature transcripts compared between hCD2+ Foxp3-positive (T_pos) and hCD22 Foxp3-negative (T_neg) TGF-b–treated CD4+ T cells and untreated (UT), activated CD4+ T cells, generated as described in (A). Data are from five biological replicate samples. by guest on September 30, 2021

Sustained Foxp3 expression is needed to maintain emerging from treatment are de facto iTreg cells. Furthermore, the a suppressive phenotype use of TCR-transgenic Foxp32/2 mice sidesteps any potentially confounding issues of autoimmune pathology. We used Foxp3- In order to establish whether sustained expression of Foxp3 in 2/2 cTreg was needed for their suppressive function, immune- reporter mice on the Marilyn background, Marilyn.Foxp3 competent naive female Marilyn mice, which lack endogenous mice, and microarray analysis to demonstrate that although the Treg, were adoptively transferred with 5 3 105 transduced Marilyn, number of genes affected by TGF-b exposure is large, the set of 4HT-treated cTreg (Fig. 8C, 8D). The mice were then grafted genes in iTreg for which expression is correlated specifically with withamaleCBA.Rag2/2 skin graft and injected daily with ta- Foxp3 expression is surprisingly low. Finally, ectopic inducible moxifen for 28 d. All Marilyn mice without cTreg cells rejected nuclear Foxp3 expression was used to demonstrate that continuous their grafts within 11 d, as expected. Mice with grafts together expression of Foxp3 on a per-cell basis was required for mainte- with cTreg tolerated their grafts for 40 d (12 d beyond the last nance of induced tolerance. injection of tamoxifen). Thus, cTreg can suppress rejection of We present five novel findings. First, the potential to express an allogeneic graft, but this requires sustained exposure to ta- Foxp3 is essential for this form of induced peripheral tolerance. moxifen. Second, a TGF-b experience in the absence of Foxp3 is insuffi- cient for tolerance despite inducing a significant TGF-b gene Discussion signature. Third, TGF-b signaling to T cells, although essential for We had set out to test the extent to which induction of Foxp3 induction of tolerance, is not essential for suppression by iTreg. expression explained the need for TGF-b signaling to T cells in Fourth, sustained functional expression of Foxp3 in vivo is nec- eliciting tolerance to transplanted tissues (6). We made use of essary to ensure prolonged graft survival. Fifth, iTreg have inde- TCR-transgenic mice on a Rag2/2 background. Untreated, these pendent TGF-b and Foxp3 gene signatures, the latter consisting of mice have no Foxp3+CD4+ T cells, so that any Foxp3+ cells a relatively small number of genes. 8 Foxp3 AND TGF-b IN ACQUIRED TOLERANCE Downloaded from

FIGURE 6. cFoxp3-transduced T cells display anergy and upregulate Treg markers in response to 4HT. (A) Nuclear translocation of GFP-Foxp3-ERT2 64 h from the onset of cFoxp3 transduction, with or without inclusion of 4HT in the culture medium. FACS-sorted CD4+CD252 B6 splenic T cells were prepared as per Materials and Methods. Thin arrows point to noninduced cells, which show distinct localization of GFP and DRAQ-5 staining, whereas wide arrows point to 4HT-induced cells that show colocalization. Data are representative of three separate experiments. (B) Three random microscopy ﬁelds were selected per sample for each of the time points, 40 and 60 h from the onset of transduction, and cells that showed colocalization of GFP and DRAQ-5

stain were counted as having undergone nuclear translocation of the cFoxp3-encoded fusion protein. Each field examined contained at least 20 cells, with an http://www.jimmunol.org/ average of 30 cells counted per field. The error bars represent SEM for the three counted fields. Two-way ANOVA was used to compare both time points and the two conditions (no 4HT versus 4HT added): p , 0.01. Data are representative of two separate experiments. (C) Marilyn CD4+ cells were transduced with cFoxp3 or empty vector. Forty hours after transduction, cells were MoFlo sorted with respect to expression of CD4 and GFP expression and incubated for a further 66 h with mitomycin C-treated HYAb-pulsed female B6 BMDCs, with or without inclusion of 4HT. Cell proliferation was assessed by [3H]thymidine incorporation. The statistical significance of inhibited proliferation by nuclear Foxp3 was calculated using two-way ANOVA with Bonferroni posttest: p , 0.01. Data are representative of two separate experiments. (D) cTreg stained for CTLA4, CD25, and GITR. FACS-sorted CD4+CD252 B6 splenic T cells transduced with cFoxp3 were cultured in the absence or presence of 4HT for 64 h prior to FACS staining. Untransduced cells and cells transduced with empty vector were used as negative controls. Cells were fixed and permeabilized prior to intracellular staining for Foxp3 and CTLA4. Data are represented as mean fluorescence intensities and representative of two separate experiments. White bars indicate cells with no 4HT added. Black bars indicate cTreg with 50 nM 4HT included in the cultures. by guest on September 30, 2021

The literature describes many different CD4+ T cell subsets from that for iTreg in experimental models. Whatever emerges exhibiting regulatory properties. These include TGF-b–secreting as the normal physiological role for iTreg, it is clear that they Th3 cells (22, 23), IL-10–secreting Tr1 cells (24), and IL-35–se- play a crucial role in therapeutic tolerance in TCR-transgenic creting iTr35 cells (25). We have previously shown that mainte- mice, as demonstrated in this study. This coupled with the ab- nance of tolerated allogeneic skin grafts required constant sup- solute need for TGF-b signaling to T cells for transplantation pression by Foxp3+ cells (8). In this study, we show for the first tolerance in conventional mice suggests that iTreg are also very time, to our knowledge, that Foxp3 expression is essential for the relevant in that context. induction of tolerance. Any other potentially suppressive mecha- Foxp3 has been shown to have binding regions on ∼700 genes nisms such as Tr1 cells did not emerge as effective substitutes for in nTreg, as well as forming a supramolecular complex with Foxp3+ T cells. other transcription factors and chromatin modifiers (21). Per- In Marilyn mice, tolerance by coreceptor blockade relies on the sistent Foxp3 expression is likely needed to maintain the tran- TGF-b–dependent de novo differentiation of iTreg (6). We pro- scriptional changes and epigenetic alterations of target genes pose, therefore, that failure to induce tolerance in the Marilyn. that it controls. We performed extensive transcript analysis using Foxp32/2 mice was due to failure to generate Foxp3-expressing exon tiling microarrays and demonstrated that T cells have iTreg cells. Consistent with that, Ag-activated Marilyn.Foxp32/2 ∼3000 transcripts significantly altered in expression by TGF-b. CD4+ T cells cultured in the presence of TGF-b (9) remained However, subtractive comparisons of the transcriptome of TGF- responsive to Ag in vitro and could still reject grafts in vivo, b–experienced T cells that did not convert to Foxp3 expression suggesting that any other TGF-b–induced mechanisms were in- (HYT CD4+hCD22 cells from Marilyn.Foxp3hCD2)orTGF- sufficient to both calm the cells and to convert them to potent b-experienced Foxp3 2/2 CD4+ T cells showed a very limited regulatory function. signature of 27 genes influenced solely by Foxp3 in iTreg. Thus, It is still unclear whether iTreg play a major role in the control although Foxp3 can bind hundreds of genes in thymically de- of immune homeostasis. Numerous studies have shown that rived Treg, resulting in up and down gene regulation, in our Foxp3+ iTreg can arise in a number of experimental settings. populations of iTreg, the number of genes significantly altered in These include exposure of T cells to cognate Ag in the absence expression by Foxp3 was much more limited. Foxp3 expression of microbial or endogenous danger signals as in the case of is controlled in part by variable DNA methylation at the Treg- mucosally (26), as well as parenterally delivered Ags (27). It specific demethylated region (28, 29). The transcriptional and has, however, been difficult to separate the need for nTreg away epigenetic modifications initiated by Foxp3 may not be sufficient The Journal of Immunology 9

FIGURE 7. cTreg secrete very low levels of proinﬂammatory cytokines. Downloaded from CD4+CD252 cells puriﬁed from B6 spleens were transduced with cFoxp3 or empty vector (empty). For comparison, Foxp3+ nTreg were isolated from B6.Foxp3hCD2 mice by MoFlo sorting based on hCD2 expression. + 2 FIGURE 8. Sustained Foxp3 expression is required for maintenance of Negative control cells (Ctr) were untransfected CD4 CD25 cells. A + + a suppressive phenotype. ( ) Marilyn CD4 T cells were transduced with Transduced CD4 cells were MoFlo sorted based on GFP expression 40 h cFoxp3 and either treated or not treated with 4HT to induce nuclear lo- 3 5 after the onset of transduction and plated at 2 10 cells/well in fresh calization of GFP-Foxp3-ERT. After 48 h, transduced cells were sorted medium on anti-CD3–coated 96-well plates with (black bars) or without based on CD4 and GFP expression (sorted cells indicated by rectangles). http://www.jimmunol.org/ (white bars) 4HT for a further 48 h. Supernatant was collected and ana- Data are representative of three experiments. (B) Splenic CD4+ cells from lyzed using a custom Bio-Plex Multiplex Cytokine Assay. For statistical Marilyn mice were transduced with cFoxp3, and half received in vitro 4HT analysis, one-way ANOVA with Dunnett’s comparison test was used (all treatment. A total of 2 3 104 or 1 3 106 cells was sorted for expression of groups compared with untransduced cells). Data represent technical trip- GFP and transferred into B6.Rag2/2 mice. These mice received daily ta- 6 . licates SEM. Data are representative of two separate experiments. , moxifen (1 mg i.p.). As controls, some recipients did not receive in vivo . 5 p # p # 10 pg/ml. * 0.05, *** 0.001. tamoxifen treatment, but received vehicle alone. Graft rejection was monitored daily. On day 28, tamoxifen treatment was ceased, and graft rejection followed until day 56. Data are representative of two separate C + D

experiments. ( ) MoFlo FACS profile of sorted GFP cTreg used in ( ). by guest on September 30, 2021 to render the cell regulatory in the absence of continued Foxp3 (D) A total of 5 3 105 MoFlo-sorted in vitro 4HT-treated cFoxp3-trans- expression. Cre-lox deletion of the Foxp3 gene in mature Treg duced cells were transferred into Marilyn mice (n = 4) followed the next was found to result in reversal of their regulatory characteristics day by transplantation of a male CBA.Rag2/2 graft. Daily tamoxifen (1 and acquisition of ability to produce proinflammatory cytokines mg) was administered. Control recipients (n = 4) did not receive cells, but (30). were treated with daily tamoxifen. Data are representative of two separate We have shown that sustained nuclear Foxp3 expression is re- experiments. quired to maintain a cellular program compatible with regulation. For a regulatory cell to suppress, one desirable function would be that it limits its own production of proinflammatory cytokines. We NOD background, consistent with previous reports showing Th17 observed such behavior for IL-1, IL-2, IL-4, IL-9, IL-17, and IFN- cells to be protective in this model. We have shown that Th17 cells g, all of which were reduced to low levels following tamoxifen- mediate damage in allogeneic skin graft rejection (35), thus the induced nuclear localization of GFP-Foxp3-ERT2 in cFoxp3- + potency of our conditional Treg, which have an N-terminal GFP transduced Marilyn CD4 T cells. The requirement for sustained tagged Foxp3 may be explained in part by this phenomenon. suppression to maintain tolerance has already been argued where These studies reinforce and extend our earlier findings that tolerance was lost when Foxp3-expressing cells were deleted (8, Foxp3+ cells are critical for clinically relevant modes of tolerance 31). We have shown that simple withdrawal of tamoxifen in this induction. The role of TGF-b can be adequately accounted for by system is sufficient to revert cTreg to an effector phenotype. Ta- the induction of Foxp3 gene expression and a narrow set of Foxp3 moxifen in an equivalent setting in human T cells has been shown influenced genes and no other feature of TGF-b signaling. The to induce nuclear localization as well as increase the stability of implications of these findings are that clinical efforts to harness the fusion protein (32). Withdrawal of tamoxifen resulted in re- induced Foxp3+ cells for tolerance will need to ensure the stable versal of the inhibition of IFN-g production (32). Thus, lowering expression of Foxp3 as its role in Treg is not a transient one, but the expression and changing the subcellular localization of Foxp3 one requiring persistent expression. from nucleus to cytoplasm is a potent switch to mediate loss of suppressive activity. Two recent reports have shown that N-terminal addition of GFP Acknowledgments to Foxp3 can alter the interaction of Foxp3 with HIF-1a, Eos, We thank Dr. Nigel Rust for expert FACS sorting, the Pathology Support HDAC7, and TIP60, whereas interaction with NFAT is unaltered Building staff for excellent animal husbandry, and Dr. Amin Moghaddam (33, 34). This led to a decrease in proteasomal degradation of for expert assistance with cytokine assays. Foxp3 and subtle alterations of the genes inhibited by Foxp3. The result of these alterations was increased suppression of Th17 Disclosures responses, resulting in increased susceptibility to diabetes on the The authors have no financial conflicts of interest. 10 Foxp3 AND TGF-b IN ACQUIRED TOLERANCE

References 19. Josefowicz, S. Z., L. F. Lu, and A. Y. Rudensky. 2012. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30: 531–564. 1. Klein, L., and K. Jovanovic. 2011. Regulatory T cell lineage commitment in the 20. Marson, A., K. Kretschmer, G. M. Frampton, E. S. Jacobsen, J. K. Polansky, thymus. Semin. Immunol. 23: 401–409. K. D. MacIsaac, S. S. Levine, E. Fraenkel, H. von Boehmer, and R. A. Young. 2. Lio, C. W., and C. S. Hsieh. 2011. Becoming self-aware: the thymic education of regulatory T cells. Curr. Opin. Immunol. 23: 213–219. 2007. Foxp3 occupancy and regulation of key target genes during T-cell stim- 3. Chen, W., W. Jin, N. Hardegen, K. J. Lei, L. Li, N. Marinos, G. McGrady, and ulation. Nature 445: 931–935. S. M. Wahl. 2003. Conversion of peripheral CD4+CD25- naive T cells to CD4 21. Zheng, Y., S. Z. Josefowicz, A. Kas, T. T. Chu, M. A. Gavin, and +CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. A. Y. Rudensky. 2007. Genome-wide analysis of Foxp3 target genes in devel- J. Exp. Med. 198: 1875–1886. oping and mature regulatory T cells. Nature 445: 936–940. 4. Cobbold, S. P., R. Castejon, E. Adams, D. Zelenika, L. Graca, S. Humm, and 22. Carrier, Y., J. Yuan, V. K. Kuchroo, and H. L. Weiner. 2007. Th3 cells in pe- H. Waldmann. 2004. Induction of foxP3+ regulatory T cells in the periphery of ripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172: 6003– derived from TGF-beta T cell-transgenic mice. J. Immunol. 178: 179–185. 6010. 23. Zheng, S. G., J. D. Gray, K. Ohtsuka, S. Yamagiwa, and D. A. Horwitz. 2002. 5. Kretschmer, K., I. Apostolou, D. Hawiger, K. Khazaie, M. C. Nussenzweig, and Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- H. von Boehmer. 2005. Inducing and expanding regulatory T cell populations by precursors. J. Immunol. 169: 4183–4189. foreign antigen. Nat. Immunol. 6: 1219–1227. 24. Levings, M. K., R. Bacchetta, U. Schulz, and M. G. Roncarolo. 2002. The role of 6. Daley, S. R., J. Ma, E. Adams, S. P. Cobbold, and H. Waldmann. 2007. A key IL-10 and TGF-beta in the differentiation and effector function of T regulatory role for TGF-beta signaling to T cells in the long-term acceptance of allografts. cells. Int. Arch. Allergy Immunol. 129: 263–276. J. Immunol. 179: 3648–3654. 25. Collison, L. W., V. Chaturvedi, A. L. Henderson, P. R. Giacomin, C. Guy, 7. Benjamin, R. J., and H. Waldmann. 1986. Induction of tolerance by monoclonal J. Bankoti, D. Finkelstein, K. Forbes, C. J. Workman, S. A. Brown, et al. 2010. antibody therapy. Nature 320: 449–451. IL-35-mediated induction of a potent regulatory T cell population. Nat. Immunol. 8. Kendal, A. R., Y. Chen, F. S. Regateiro, J. Ma, E. Adams, S. P. Cobbold, S. Hori, 11: 1093–1101. and H. Waldmann. 2011. Sustained suppression by Foxp3+ regulatory T cells is 26. Curotto de Lafaille, M. A., N. Kutchukhidze, S. Shen, Y. Ding, H. Yee, and vital for infectious transplantation tolerance. J. Exp. Med. 208: 2043–2053. J. J. Lafaille. 2008. Adaptive Foxp3+ regulatory T cell-dependent and -inde-

9. Regateiro, F. S., D. Howie, K. F. Nolan, E. I. Agorogiannis, D. R. Greaves, Downloaded from S. P. Cobbold, and H. Waldmann. 2011. Generation of anti-inflammatory pendent control of allergic inflammation. Immunity 29: 114–126. adenosine by leukocytes is regulated by TGF-b. Eur. J. Immunol. 41: 2955– 27. Verginis, P., K. A. McLaughlin, K. W. Wucherpfennig, H. von Boehmer, and 2965. I. Apostolou. 2008. Induction of antigen-specific regulatory T cells in wild-type 10. Cobbold, S. P., L. Graca, C. Y. Lin, E. Adams, and H. Waldmann. 2003. Reg- mice: visualization and targets of suppression. Proc. Natl. Acad. Sci. USA 105: ulatory T cells in the induction and maintenance of peripheral transplantation 3479–3484. tolerance. Transpl. Int. 16: 66–75. 28. Floess, S., J. Freyer, C. Siewert, U. Baron, S. Olek, J. Polansky, K. Schlawe, 11. Rao, P. E., A. L. Petrone, and P. D. Ponath. 2005. Differentiation and expansion H. D. Chang, T. Bopp, E. Schmitt, et al. 2007. Epigenetic control of the foxp3 of T cells with regulatory function from human peripheral lymphocytes by locus in regulatory T cells. PLoS Biol. 5: e38. stimulation in the presence of TGF-beta. J. Immunol. 174: 1446–1455. 29. Lal, G., N. Zhang, W. van der Touw, Y. Ding, W. Ju, E. P. Bottinger, S. P. Reid, http://www.jimmunol.org/ 12. Haribhai, D., W. Lin, B. Edwards, J. Ziegelbauer, N. H. Salzman, M. R. Carlson, D. E. Levy, and J. S. Bromberg. 2009. Epigenetic regulation of Foxp3 expression S. H. Li, P. M. Simpson, T. A. Chatila, and C. B. Williams. 2009. A central role in regulatory T cells by DNA methylation. J. Immunol. 182: 259–273. for induced regulatory T cells in tolerance induction in experimental colitis. J. 30. Williams, L. M., and A. Y. Rudensky. 2007. Maintenance of the Foxp3- Immunol. 182: 3461–3468. dependent developmental program in mature regulatory T cells requires con- 13. Andersson, J., D. Q. Tran, M. Pesu, T. S. Davidson, H. Ramsey, J. J. O’Shea, and tinued expression of Foxp3. Nat. Immunol. 8: 277–284. E. M. Shevach. 2008. CD4+ FoxP3+ regulatory T cells confer infectious toler- 31. Lahl, K., C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, ance in a TGF-beta-dependent manner. J. Exp. Med. 205: 1975–1981. A. Hamann, H. Wagner, J. Huehn, and T. Sparwasser. 2007. Selective depletion 14. Lantz, O., I. Grandjean, P. Matzinger, and J. P. Di Santo. 2000. Gamma chain of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med. 204: 57– required for naı¨ve CD4+ T cell survival but not for antigen proliferation. Nat. 63. Immunol. 1: 54–58. 32. Allan, S. E., G. X. Song-Zhao, T. Abraham, A. N. McMurchy, and 15. Gorelik, L., and R. A. Flavell. 2000. Abrogation of TGFbeta signaling in T cells

M. K. Levings. 2008. Inducible reprogramming of human T cells into Treg cells by guest on September 30, 2021 leads to spontaneous T cell differentiation and autoimmune disease. Immunity by a conditionally active form of FOXP3. Eur. J. Immunol. 38: 3282–3289. 12: 171–181. 33. Bettini, M. L., F. Pan, M. Bettini, D. Finkelstein, J. E. Rehg, S. Floess, 16. Qin, S. X., M. Wise, S. P. Cobbold, L. Leong, Y. C. Kong, J. R. Parnes, and H. Waldmann. 1990. Induction of tolerance in peripheral T cells with mono- B. D. Bell, S. F. Ziegler, J. Huehn, D. M. Pardoll, and D. A. Vignali. 2012. Loss clonal antibodies. Eur. J. Immunol. 20: 2737–2745. of epigenetic modification driven by the Foxp3 transcription factor leads to 17. Nolan, K. F., V. Strong, D. Soler, P. J. Fairchild, S. P. Cobbold, R. Croxton, regulatory T cell insufficiency. Immunity 36: 717–730. J. A. Gonzalo, A. Rubio, M. Wells, and H. Waldmann. 2004. IL-10-conditioned 34. Darce, J., D. Rudra, L. Li, J. Nishio, D. Cipolletta, A. Y. Rudensky, D. Mathis, dendritic cells, decommissioned for recruitment of adaptive immunity, elicit and C. Benoist. 2012. An N-terminal mutation of the Foxp3 transcription factor innate inflammatory gene products in response to danger signals. J. Immunol. alleviates arthritis but exacerbates diabetes. Immunity 36: 731–741. 172: 2201–2209. 35. Agorogiannis, E. I., F. S. Regateiro, D. Howie, H. Waldmann, and S. P. Cobbold. 18. Andersen, K. G., T. Butcher, and A. G. Betz. 2008. Specific immunosuppression 2012. Th17 cells induce a distinct graft rejection response that does not require with inducible Foxp3-transduced polyclonal T cells. PLoS Biol. 6: e276. IL-17A. Am. J. Transplant. 12: 835–845. Regateiro et al Supplementary Figure 1

A 4 4 10 10 Marilyn Marilyn.Foxp3-/- 3 103 10

RII 2

β 2 10 10

TGF 1 101 10

1 2 3 4 4 10 10 10 10 1 2 3 10 10 10 10 CD4 B

Supplementary Figure 1

A. Marilyn.Foxp3-/- CD4+ T cells express similar levels of TGFβRII to wildtype Marilyn CD4+ T cells.

Splenic CD4+ T cells from Marilyn or Marilyn.Foxp3-/- were stained with anti-CD4-APC and anti-TGFβRII-PE. Red dots represent control isotype (PE) staining, blue dots represent staining for TGFβRII.

B. Very few Marilyn CD4+ T cells are needed to reject a male skin graft in female B6.Rag-/- recepients.

FACS analysis was performed to determine the proportion of CD4+ cells in female Marilyn spleens. Splenocytes were stained with both anti-CD4-FITC and anti-CD4-PE antibodies and an average of the two was deemed as the CD4+ percentage (2.4%). Whole splenocytes containing the required number of CD4+ cells were then transferred into female B6.Rag-/- recipients. Various numbers of CD4+ cells were transferred and the mice grafted with a male CBA.Rag-/- skin on the following day. Grafts were monitored on a daily basis. Difference in rejection kinetics between the groups was not statistically significant. Regateiro et al Supplementary Table I Probe log ratio Set ID T/UT p-value Gene Symbol mRNA - Description mRNA Accession 6782286 3.609099 3.03E-07 Itgae integrin alpha E, epithelial-associated NM_008399 (Itgae), transcript variant 1, mRNA. 6991192 3.391555 3.03E-07 Nt5e 5' nucleotidase, ecto (Nt5e), mRNA. NM_011851 6931759 3.345072 4.09E-05 Kit kit oncogene (Kit), transcript variant 1, NM_001122733 mRNA. 6759549 3.052253 2.12E-08 Ikzf2 IKAROS family zinc finger 2 (Ikzf2), mRNA. NM_011770

6861751 2.519725 8.91E-08 D18Ertd653e DNA segment, Chr 18, ERATO Doi 653, BC096371 expressed, mRNA (cDNA clone MGC:106263 IMAGE:3583946), complete cds. 6905818 2.43495 6.24E-08 Ift80 intraflagellar transport 80 homolog NM_026641 (Chlamydomonas) (Ift80), mRNA. 6910668 2.332868 2.77E-07 St6galnac3 // ST6 (alpha-N-acetyl-neuraminyl-2,3-beta- NM_011372 St6galnac3 galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (St6galnac3), mRNA. 7007950 2.192809 0.000363 Olfr46 olfactory receptor 46 (Olfr46), mRNA. NM_146934 6895856 2.096735 0.004338 Car2 carbonic anhydrase 2 (Car2), mRNA. NM_009801 6777309 2.058745 8.26E-05 Lyz2 lysozyme 2 (Lyz2), mRNA. NM_017372 6848579 1.994756 0.000346 Ccr6 chemokine (C-C motif) receptor 6 (Ccr6), NM_009835 transcript variant 1, mRNA. 6908461 1.890582 0.000161 S1pr1 sphingosine-1-phosphate receptor 1 NM_007901 (S1pr1), mRNA. 6792832 1.882423 2.91E-05 Cd7 CD7 antigen (Cd7), mRNA. NM_009854 6917997 1.803919 1.02E-06 Camk2n1 calcium/calmodulin-dependent protein NM_025451 kinase II inhibitor 1 (Camk2n1), mRNA. 6763731 1.796393 0.000556 Xcl1 chemokine (C motif) ligand 1 (Xcl1), NM_008510 mRNA. 6955698 1.772842 1.93E-05 Lrig1 leucine-rich repeats and immunoglobulin- NM_008377 like domains 1 (Lrig1), mRNA. 6748889 1.732433 4.29E-05 Il18r1 interleukin 18 receptor 1 (Il18r1), transcript NM_008365 variant 1, mRNA. 6837614 1.723663 1.96E-05 Cerk ceramide kinase (Cerk), mRNA. NM_145475 6764650 1.718202 1.66E-05 Ephx1 epoxide hydrolase 1, microsomal (Ephx1), NM_010145 mRNA. 6876914 1.664382 0.000138 Acvr2a activin receptor IIA (Acvr2a), mRNA. NM_007396 6757898 1.643344 7.89E-06 Neurl3 neuralized homolog 3 homolog NM_153408 (Drosophila) (Neurl3), mRNA. 6986359 1.614005 0.002372 Defa21 defensin, alpha, 21 (Defa21), mRNA. NM_183253 6802098 1.608321 3.6E-05 Actn1 actinin, alpha 1 (Actn1), mRNA. NM_134156 6791310 1.597657 1.54E-05 Ccr7 chemokine (C-C motif) receptor 7 (Ccr7), NM_007719 mRNA. 6873368 1.584057 4.75E-05 Kcnip2 Kv channel-interacting protein 2 (Kcnip2), NM_145703 transcript variant a, mRNA. 6840112 1.571175 1.39E-05 BC106179 cDNA sequence BC106179, mRNA (cDNA BC106179 clone MGC:118427 IMAGE:6509459), complete cds. 6919417 1.564054 2.78E-06 Tox thymocyte selection-associated high NM_145711 mobility group box (Tox), mRNA. 6946920 1.562271 0.006492 Cd8a CD8 antigen, alpha chain (Cd8a), NM_001081110 transcript variant 1, mRNA. 6884820 1.524667 0.002764 St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8- NM_145838 sialyltransferase 6 (St8sia6), mRNA. 6755216 1.514428 0.000115 Slamf6 SLAM family member 6 (Slamf6), mRNA. NM_030710

6954269 1.507733 0.000367 Hpgds hematopoietic prostaglandin D synthase NM_019455 (Hpgds), mRNA. 6963006 1.492523 0.000944 Pde2a phosphodiesterase 2A, cGMP-stimulated NM_001143848 (Pde2a), transcript variant 1, mRNA.

6791230 1.460221 0.001001 Arl5c ADP-ribosylation factor-like 5C (Arl5c), NM_207231 mRNA. 6764274 1.431221 0.000696 Ifi203 interferon activated gene 203 (Ifi203), NM_001045481 transcript variant 1, mRNA. 6788172 1.429802 2.1E-05 Tcf7 transcription factor 7, T-cell specific (Tcf7), NM_009331 mRNA. 6899683 1.380406 0.0002 Ctss cathepsin S (Ctss), mRNA. NM_021281 6769481 1.374489 0.000589 Btbd11 BTB (POZ) domain containing 11 (Btbd11), NM_028709 transcript variant 1, mRNA. 6898241 1.363875 6.62E-06 Smc4 structural maintenance of chromosomes 4 NM_133786 (Smc4), mRNA. 6886101 1.359014 0.001778 Olfr351 olfactory receptor 351 (Olfr351), mRNA. NM_146942 6844653 1.352185 0.000136 Bcl6 B-cell leukemia/lymphoma 6 (Bcl6), NM_009744 mRNA. 6848553 1.34033 0.001044 Tagap T-cell activation Rho GTPase-activating NM_145968 protein (Tagap), mRNA. 6888681 1.336101 0.007181 Olfr1270 olfactory receptor 1270 (Olfr1270), mRNA. NM_146985

6792649 1.310334 0.0001 Timp2 tissue inhibitor of metalloproteinase 2 NM_011594 (Timp2), mRNA. 6810260 1.307509 3.28E-05 Il6st interleukin 6 signal transducer (Il6st), NM_010560 mRNA. 6783489 1.30335 0.000129 Mmd monocyte to macrophage differentiation- NM_026178 associated (Mmd), mRNA. 6841019 1.301827 1.91E-05 Zbtb20 zinc finger and BTB domain containing 20 NM_019778 (Zbtb20), transcript variant 1, mRNA. 6850308 1.294014 0.00102 Olfr111 olfactory receptor 111 (Olfr111), mRNA. NM_001005485 6935408 1.281461 9.81E-05 Cyth3 cytohesin 3 (Cyth3), transcript variant 1, NM_011182 mRNA. 6768076 1.255537 9.29E-05 Smpdl3a sphingomyelin phosphodiesterase, acid- NM_020561 like 3A (Smpdl3a), mRNA. 6805430 1.25248 0.000121 Cmah cytidine monophospho-N-acetylneuraminic NM_001111110 acid hydroxylase (Cmah), transcript variant 2, mRNA. 6808964 1.234387 0.001289 Serinc5 serine incorporator 5 (Serinc5), mRNA. NM_172588 6790290 1.23392 0.000331 Ccl6 chemokine (C-C motif) ligand 6 (Ccl6), NM_009139 mRNA. 6820219 1.233595 0.000139 Lpar6 lysophosphatidic acid receptor 6 (Lpar6), NM_175116 mRNA. 7015465 1.230841 0.000855 Ssxb2 synovial sarcoma, X member B, breakpoint NM_001001450 2 (Ssxb2), transcript variant 1, mRNA.

6969994 1.229294 0.004665 Olfr68 olfactory receptor 68 (Olfr68), mRNA. NM_013620 7020802 1.212492 0.000176 Tlr7 toll-like receptor 7 (Tlr7), mRNA. NM_133211 6848721 1.203569 0.000183 --- cdna:known ENSMUST00000161890 chromosome:NCBIM37:17:13008797:1302 3201:1 gene:ENSMUSG00000078247 6980578 1.202565 0.002063 Rasa3 RAS p21 protein activator 3 (Rasa3), NM_009025 mRNA. 7015521 1.200518 0.005351 Cybb cytochrome b-245, beta polypeptide NM_007807 (Cybb), mRNA. 6955879 1.194786 2.17E-05 Foxp1 forkhead box P1 (Foxp1), transcript variant NM_053202 1, mRNA. 6822946 1.18296 0.000244 Nr1d2 nuclear receptor subfamily 1, group D, NM_011584 member 2 (Nr1d2), mRNA. 6778284 1.180345 0.002406 Pik3ip1 phosphoinositide-3-kinase interacting NM_178149 protein 1 (Pik3ip1), mRNA. 6923411 1.172697 0.007362 Jun Jun oncogene (Jun), mRNA. NM_010591 6790291 1.170038 5.13E-05 Ccl9 chemokine (C-C motif) ligand 9 (Ccl9), NM_011338 mRNA. 6833311 1.155539 0.000157 Nr4a1 nuclear receptor subfamily 4, group A, NM_010444 member 1 (Nr4a1), mRNA. 6848718 1.147284 0.000139 Airn antisense Igf2r RNA (Airn), transcript NR_027784 variant 4, antisense RNA. 6808876 1.135916 0.000361 Ssbp2 single-stranded DNA binding protein 2 NM_024272 (Ssbp2), transcript variant 2, mRNA. 6933441 1.133614 0.009838 --- cdna:known ENSMUST00000129007 chromosome:NCBIM37:5:110950181:1109 54999:1 gene:ENSMUSG00000048215

6969948 1.127802 0.008469 Olfr33 olfactory receptor 33 (Olfr33), mRNA. NM_147073 6902880 1.119946 0.001368 Wls wntless homolog (Drosophila) (Wls), NM_026582 mRNA. 6921012 1.112982 1.87E-06 Aqp3 aquaporin 3 (Aqp3), mRNA. NM_016689 6810548 1.110857 7.93E-05 Emb embigin (Emb), mRNA. NM_010330 6880776 1.099152 0.000189 Sema6d sema domain, transmembrane domain NM_199241 (TM), and cytoplasmic domain, (semaphorin) 6D (Sema6d), transcript variant 4, mRNA. 6942376 1.096305 0.009594 Ncf1 neutrophil cytosolic factor 1 (Ncf1), mRNA. NM_010876 6836954 1.094861 0.002967 Apol7b apolipoprotein L 7b (Apol7b), mRNA. NM_001024848 6786673 1.084076 0.000393 Rel reticuloendotheliosis oncogene (Rel), NM_009044 mRNA. 6892032 1.080852 0.00031 Acss1 acyl-CoA synthetase short-chain family NM_080575 member 1 (Acss1), nuclear gene encoding mitochondrial protein, mRNA. 6862133 1.07929 0.000181 Smad7 MAD homolog 7 (Drosophila) (Smad7), NM_001042660 mRNA. 6879998 1.056416 0.006895 Olfr1288 olfactory receptor 1288 (Olfr1288), mRNA. NM_146400

6803113 1.048371 0.000375 Gpr68 G protein-coupled receptor 68 (Gpr68), NM_175493 transcript variant 1, mRNA. 6758001 1.046924 0.000215 Aff3 AF4/FMR2 family, member 3 (Aff3), NM_010678 mRNA. 6870424 1.046841 0.000686 Add3 adducin 3 (gamma) (Add3), transcript NM_001164099 variant 1, mRNA. 6866257 1.041162 0.00229 Mc4r melanocortin 4 receptor (Mc4r), mRNA. NM_016977 6790531 1.040432 0.003029 Ypel2 yippee-like 2 (Drosophila) (Ypel2), mRNA. NM_001005341

6836325 1.036394 0.00089 Tmem71 transmembrane protein 71 (Tmem71), NM_172514 mRNA. 6878712 1.034908 0.00055 Slc43a1 solute carrier family 43, member 1 NM_001081349 (Slc43a1), transcript variant 1, mRNA. 6878045 1.029235 0.000399 --- cdna:known ENSMUST00000151236 chromosome:NCBIM37:2:71978785:72001 443:1 gene:ENSMUSG00000049044 6871509 1.02794 0.006802 Cd5 CD5 antigen (Cd5), mRNA. NM_007650 6986722 1.02683 0.001061 Mmp12 matrix metallopeptidase 12 (Mmp12), NM_008605 mRNA. 6949744 1.010036 0.000113 Clec4n C-type lectin domain family 4, member n NM_020001 (Clec4n), transcript variant 1, mRNA. 6930383 1.005898 0.002709 Cd38 CD38 antigen (Cd38), mRNA. NM_007646 6988958 1.005195 0.007024 Usp28 ubiquitin specific peptidase 28 (Usp28), NM_175482 mRNA. 6769445 1.003119 0.007456 Tcp11l2 t-complex 11 (mouse) like 2 (Tcp11l2), NM_146008 mRNA. 6939076 0.999529 0.001718 Txk TXK tyrosine kinase (Txk), transcript NM_013698 variant 2, mRNA. 6919612 0.995662 0.008535 --- (ORF 1) and reverse transcriptase (ORF 2) U15647 genes, complete cds. 6779827 0.99522 2.71E-05 Nsg2 neuron specific gene family member 2 NM_008741 (Nsg2), mRNA. 6846010 0.993392 0.000239 Cd96 CD96 antigen (Cd96), mRNA. NM_032465 6963074 0.989453 0.001807 Olfr570 olfactory receptor 570 (Olfr570), mRNA. NM_147110 6977151 0.983216 0.002878 Klf2 Kruppel-like factor 2 (lung) (Klf2), mRNA. NM_008452

6888537 0.981679 0.001813 Olfr1163 olfactory receptor 1163 (Olfr1163), mRNA. NM_146644

6899572 0.978848 0.002741 Rorc RAR-related orphan receptor gamma NM_011281 (Rorc), mRNA. 6921154 0.966006 0.00063 Cd72 CD72 antigen (Cd72), transcript variant 1, NM_001110320 mRNA. 6946370 0.961834 0.000277 2410066E13Ri RIKEN cDNA 2410066E13 gene, mRNA BC042507 k (cDNA clone MGC:30499 IMAGE:4235651), complete cds. 6961283 0.957828 0.001602 D930030O05R 15 days embryo head cDNA, RIKEN full- AK086466 ik length enriched library, clone:D930030O05 product:hypothetical Proline-rich region profile containing protein, full insert sequence. 6991368 0.956107 0.000213 Plscr4 phospholipid scramblase 4 (Plscr4), NM_178711 mRNA. 6857799 0.95382 0.008619 Thada thyroid adenoma associated (Thada), NM_183021 mRNA. 6878038 0.943965 0.000884 Rapgef4 Rap guanine nucleotide exchange factor NM_019688 (GEF) 4 (Rapgef4), mRNA. 6855238 0.938762 0.005365 Olfr97 olfactory receptor 97 (Olfr97), mRNA. NM_146512 6964428 0.936554 0.003742 Inpp5f inositol polyphosphate-5-phosphatase F NM_178641 (Inpp5f), mRNA. 6814827 0.932814 0.000764 Rasa1 RAS p21 protein activator 1 (Rasa1), NM_145452 mRNA. 6889729 0.931112 0.008282 Olfr1305 olfactory receptor 1305 (Olfr1305), mRNA. NM_146401 6990263 0.929642 0.00301 Myo1e myosin IE (Myo1e), mRNA. NM_181072 6774719 0.92467 0.001918 Arid5b AT rich interactive domain 5B (MRF1-like) NM_023598 (Arid5b), mRNA. 6892504 0.923883 0.001933 Samhd1 SAM domain and HD domain, 1 (Samhd1), NM_001139520 transcript variant 2, mRNA. 6813666 0.92382 0.004339 Golm1 golgi membrane protein 1 (Golm1), NM_027307 transcript variant 1, mRNA. 6885855 0.915193 0.002722 Fam78a family with sequence similarity 78, member BC137951 A, mRNA (cDNA clone MGC:169575 IMAGE:8860970), complete cds.

6931529 0.908511 0.000508 Atp10d ATPase, class V, type 10D (Atp10d), non- NR_003966 coding RNA. 6791344 0.891135 0.003602 Krtap3-2 keratin associated protein 3-2 (Krtap3-2), NM_025720 mRNA. 6816317 0.890092 0.000805 Parp8 poly (ADP-ribose) polymerase family, NM_001081009 member 8 (Parp8), mRNA. 6917809 0.888759 0.006398 Id3 inhibitor of DNA binding 3 (Id3), mRNA. NM_008321 6965817 0.888254 0.005556 Vmn1r148 vomeronasal 1 receptor 148 (Vmn1r148), NM_030736 mRNA. 6960404 0.880812 0.000719 Dbp D site albumin promoter binding protein NM_016974 (Dbp), mRNA. 6921670 0.8766 0.000706 Abca1 ATP-binding cassette, sub-family A NM_013454 (ABC1), member 1 (Abca1), mRNA. 6849766 0.876365 0.003211 Abcg1 ATP-binding cassette, sub-family G NM_009593 (WHITE), member 1 (Abcg1), mRNA. 6782579 0.875236 0.000285 Abhd15 abhydrolase domain containing 15 NM_026185 (Abhd15), mRNA. 6888531 0.872218 0.002319 Olfr1155 olfactory receptor 1155 (Olfr1155), mRNA. NM_146643

6896519 0.871969 0.002626 Skil SKI-like (Skil), transcript variant 1, mRNA. NM_011386

6790079 0.864499 0.006354 Crlf3 cytokine receptor-like factor 3 (Crlf3), NM_018776 mRNA. 6850695 0.863357 0.000807 Zfp318 zinc finger protein 318 (Zfp318), transcript NM_207671 variant 1, mRNA. 6878031 0.861565 0.003237 Itga6 integrin alpha 6 (Itga6), mRNA. NM_008397 6762314 0.856501 0.006019 Lax1 lymphocyte transmembrane adaptor 1 NM_001159649 (Lax1), transcript variant 1, mRNA. 6845569 0.856099 0.002339 Arhgap31 Rho GTPase activating protein 31 NM_020260 (Arhgap31), mRNA. 6830619 0.853737 0.007322 Zhx2 zinc fingers and homeoboxes 2 (Zhx2), NM_199449 mRNA. 6963060 0.853543 0.003405 Olfr550 olfactory receptor 550 (Olfr550), mRNA. NM_147104 6964522 0.839287 0.001197 Plekha1 pleckstrin homology domain containing, NM_133942 family A (phosphoinositide binding specific) member 1 (Plekha1), mRNA. 6952097 0.835976 0.000392 Fam3c family with sequence similarity 3, member NM_138587 C (Fam3c), mRNA. 6888377 0.835826 0.004304 Olfr995 olfactory receptor 995 (Olfr995), mRNA. NM_146434 6916735 0.834941 0.002605 Olfr1339 olfactory receptor 1339 (Olfr1339), mRNA. NM_146852

6846386 0.833323 0.003866 Cep97 centrosomal protein 97 (Cep97), transcript NM_028815 variant 1, mRNA. 6913560 0.828661 7.69E-05 Slc44a1 solute carrier family 44, member 1 NM_133891 (Slc44a1), transcript variant 1, mRNA. 6913315 0.825027 0.002246 Nr4a3 nuclear receptor subfamily 4, group A, NM_015743 member 3 (Nr4a3), mRNA. 6942737 0.821911 1.39E-05 Ttyh3 tweety homolog 3 (Drosophila) (Ttyh3), NM_175274 mRNA. 6886097 0.821207 0.003022 Olfr341 olfactory receptor 341 (Olfr341), mRNA. NM_146950 6994887 0.820136 0.00929 Ubash3b ubiquitin associated and SH3 domain NM_176860 containing, B (Ubash3b), mRNA. 6959968 0.815933 0.001546 1600014C10Ri RIKEN cDNA 1600014C10 gene NM_001085385 k (1600014C10Rik), transcript variant 1, mRNA. 6788368 0.815691 0.005125 Cdc42se2 CDC42 small effector 2 (Cdc42se2), NM_178626 mRNA. 6973679 0.813268 0.001681 Arhgef18 rho/rac guanine nucleotide exchange factor NM_133962 (GEF) 18 (Arhgef18), mRNA. 6861135 0.806785 0.009842 Gramd3 GRAM domain containing 3 (Gramd3), NM_026240 mRNA. 6815268 0.805264 0.004982 F2rl1 coagulation factor II (thrombin) receptor- NM_007974 like 1 (F2rl1), mRNA. 6782563 0.804636 0.003934 Ssh2 slingshot homolog 2 (Drosophila) (Ssh2), NM_177710 mRNA. 6755713 0.803453 0.004124 Lefty1 left right determination factor 1 (Lefty1), NM_010094 mRNA. 6778057 0.797139 0.000671 Dgka diacylglycerol kinase, alpha (Dgka), mRNA. NM_016811

6942496 0.796782 0.009621 Cux1 cut-like homeobox 1 (Cux1), transcript NM_009986 variant 1, mRNA. 6857022 0.793854 0.004709 Tgif1 TGFB-induced factor homeobox 1 (Tgif1), NM_001164075 transcript variant 1, mRNA. 6980606 0.792788 0.006442 2610019F03Ri RIKEN cDNA 2610019F03 gene NM_173744 k (2610019F03Rik), mRNA. 6855248 0.788983 0.006537 Olfr113 olfactory receptor 113 (Olfr113), mRNA. NM_146289 6854658 0.787817 0.003907 Stk38 serine/threonine kinase 38 (Stk38), mRNA. NM_134115

6770030 0.786238 0.00523 Btg1 B-cell translocation gene 1, anti- NM_007569 proliferative (Btg1), mRNA. 6835938 0.785062 0.000217 Fbxo32 F-box protein 32 (Fbxo32), mRNA. NM_026346 6971437 0.783511 0.000167 Rgs10 regulator of G-protein signalling 10 NM_026418 (Rgs10), mRNA. 6960235 0.782563 0.008625 Klk1b21 kallikrein 1-related peptidase b21 NM_010642 (Klk1b21), mRNA. 6871613 0.780746 0.007011 Olfr262 olfactory receptor 262 (Olfr262), mRNA. NM_146688 6963061 0.780717 0.009877 Olfr552 olfactory receptor 552 (Olfr552), mRNA. NM_147102 7023132 0.778632 0.000401 Pisd-ps3 phosphatidylserine decarboxylase, NR_003518 pseudogene 3 (Pisd-ps3), non-coding RNA. 6888569 0.778361 0.005419 Olfr1196 olfactory receptor 1196 (Olfr1196), mRNA. NM_146464

6963566 0.774291 1.57E-05 --- RIKEN cDNA A630005I04 gene, mRNA BC150970 (cDNA clone MGC:183883 IMAGE:9087883), complete cds. 6808279 0.767577 0.003965 Pcsk1 proprotein convertase subtilisin/kexin type NM_013628 1 (Pcsk1), mRNA. 6788609 0.759106 0.005864 Olfr328 olfactory receptor 328 (Olfr328), mRNA. NM_146502 6969964 0.757941 0.004512 Olfr586 olfactory receptor 586 (Olfr586), mRNA. NM_147111 6945835 0.756969 0.00384 Olfr437 olfactory receptor 437 (Olfr437), mRNA. NM_146296 6915650 0.752591 0.00429 Inadl InaD-like (Drosophila) (Inadl), transcript NM_172696 variant 1, mRNA. 6760042 0.751057 0.007198 Fam124b family with sequence similarity 124, NM_173425 member B (Fam124b), mRNA. 6879995 0.749644 0.005852 Olfr1284 olfactory receptor 1284 (Olfr1284), mRNA. NM_146381

6964247 0.743663 0.001783 Tbx6 T-box 6 (Tbx6), mRNA. NM_011538 6994793 0.741036 0.001636 Olfr149 olfactory receptor 149 (Olfr149), mRNA. NM_207138 6898996 0.740372 0.000176 Fcrl1 Fc receptor-like 1 (Fcrl1), transcript variant NM_153090 1, mRNA. 6999677 0.738721 0.00156 Lztfl1 leucine zipper transcription factor-like 1 NM_033322 (Lztfl1), mRNA. 6824967 0.738003 0.006295 Lats2 large tumor suppressor 2 (Lats2), NM_015771 transcript variant A, mRNA. 6796043 0.736123 0.00101 Prkch protein kinase C, eta (Prkch), mRNA. NM_008856 6884456 0.730104 0.000994 Camk1d calcium/calmodulin-dependent protein NM_177343 kinase ID (Camk1d), mRNA. 6753417 0.72601 0.009127 Kif21b kinesin family member 21B (Kif21b), NM_001039472 mRNA. 6765275 0.724639 0.006763 Traf5 TNF receptor-associated factor 5 (Traf5), NM_011633 mRNA. 6749785 0.722523 0.00548 Bmpr2 bone morphogenic protein receptor, type II NM_007561 (serine/threonine kinase) (Bmpr2), mRNA.

6837144 0.709706 0.004111 Pdgfb platelet derived growth factor, B NM_011057 polypeptide (Pdgfb), mRNA. 6843384 0.704473 0.003734 Ttc3 tetratricopeptide repeat domain 3 (Ttc3), NM_009441 mRNA. 6927231 0.703635 0.006059 Tnfrsf14 tumor necrosis factor receptor superfamily, NM_178931 member 14 (herpesvirus entry mediator) (Tnfrsf14), mRNA. 6920990 0.701052 0.009677 B4galt1 UDP-Gal:betaGlcNAc beta 1,4- NM_022305 galactosyltransferase, polypeptide 1 (B4galt1), mRNA. 6807328 0.698817 0.002618 Fbxl21 F-box and leucine-rich repeat protein 21 NM_178674 (Fbxl21), mRNA. 6978923 0.696773 0.007206 Cdh1 cadherin 1 (Cdh1), mRNA. NM_009864 6905821 0.696489 0.007604 Trim59 tripartite motif-containing 59 (Trim59), NM_025863 mRNA. 6892380 0.692286 0.009786 Trpc4ap transient receptor potential cation channel, NM_001163452 subfamily C, member 4 associated protein (Trpc4ap), transcript variant 1, mRNA.

6855275 0.692135 0.000251 Olfr137 olfactory receptor 137 (Olfr137), mRNA. NM_146488 6777310 0.688713 0.009521 Lyz1 lysozyme 1 (Lyz1), mRNA. NM_013590 6970166 0.684281 0.009317 Gm4759 predicted gene 4759 (Gm4759), non- NR_003967 coding RNA. 6897441 0.68116 0.000143 Foxo1 forkhead box O1 (Foxo1), mRNA. NM_019739 6791282 0.680241 0.000214 Nr1d1 nuclear receptor subfamily 1, group D, NM_145434 member 1 (Nr1d1), mRNA. 6817059 0.679505 0.00614 Olfr31 olfactory receptor 31 (Olfr31), mRNA. NM_147027 6781984 0.673506 0.009595 Per1 period homolog 1 (Drosophila) (Per1), NM_001159367 transcript variant 2, mRNA. 6970026 0.669967 0.005002 Olfr645 olfactory receptor 645 (Olfr645), mRNA. NM_207144 6987866 0.667807 0.003665 Zbtb44 zinc finger and BTB domain containing 44 NM_001115130 (Zbtb44), transcript variant a, mRNA. 6907784 0.662251 0.000214 Olfml3 olfactomedin-like 3 (Olfml3), mRNA. NM_133859 6992012 0.655362 0.002335 Rab6b RAB6B, member RAS oncogene family NM_173781 (Rab6b), mRNA. 6878762 0.648983 0.00678 Olfr1010 olfactory receptor 1010 (Olfr1010), mRNA. NM_207149

6838303 0.64617 0.003526 Amigo2 adhesion molecule with Ig like domain 2 NM_178114 (Amigo2), transcript variant 1, mRNA. 6878798 0.644484 0.005141 Olfr1052 olfactory receptor 1052 (Olfr1052), mRNA. NM_147010

6990167 0.644293 0.002402 Rora RAR-related orphan receptor alpha (Rora), NM_013646 mRNA. 6791015 0.642268 2.08E-05 Pdk2 pyruvate dehydrogenase kinase, NM_133667 isoenzyme 2 (Pdk2), mRNA. 6767089 0.641494 0.001873 Col10a1 collagen, type X, alpha 1 (Col10a1), NM_009925 mRNA. 6953800 0.640514 0.007979 Nod1 nucleotide-binding oligomerization domain NM_172729 containing 1 (Nod1), transcript variant 1, mRNA. 6942444 0.639777 0.00448 Ccl26 chemokine (C-C motif) ligand 26 (Ccl26), NM_001013412 mRNA. 6949856 0.63452 0.005531 Vamp1 vesicle-associated membrane protein 1 NM_001080557 (Vamp1), transcript variant 2, mRNA. 6855478 0.63439 3.53E-05 Slc25a27 solute carrier family 25, member 27 NM_028711 (Slc25a27), nuclear gene encoding mitochondrial protein, mRNA. 6966143 0.629433 0.004842 Plekhg2 pleckstrin homology domain containing, NM_138752 family G (with RhoGef domain) member 2 (Plekhg2), transcript variant 1, mRNA. 6829361 0.623436 0.000573 Tiaf2 transforming growth factor beta 1-induced AF075717 factor 2 mRNA, complete cds. 6771770 0.621325 0.001113 Olfr820 olfactory receptor 820 (Olfr820), mRNA. NM_146675 6952415 0.620092 0.007453 Ube2h ubiquitin-conjugating enzyme E2H NM_009459 (Ube2h), transcript variant 1, mRNA. 6809030 0.615015 0.008082 Arsb arylsulfatase B (Arsb), mRNA. NM_009712 6993524 0.611502 0.00491 Mtnr1b melatonin receptor 1B (Mtnr1b), mRNA. NM_145712 6799524 0.611418 4.72E-05 Rnf144a ring finger protein 144A (Rnf144a), NM_001081977 transcript variant 1, mRNA. 6860176 0.610102 0.002363 Pcdhb8 protocadherin beta 8 (Pcdhb8), mRNA. NM_053133 6792427 0.607325 0.001405 C630004H02R RIKEN cDNA C630004H02 gene, mRNA BC024617 ik (cDNA clone MGC:28513 IMAGE:4190480), complete cds. 6963188 0.598557 0.002679 Olfr689 olfactory receptor 689 (Olfr689), mRNA. NM_146750 6983978 0.597251 0.00112 Siah1a seven in absentia 1A (Siah1a), mRNA. NM_009172 6926029 0.596525 0.00726 Ldlrap1 low density lipoprotein receptor adaptor NM_145554 protein 1 (Ldlrap1), mRNA. 6867686 0.586888 0.005365 Rbm4b RNA binding motif protein 4B (Rbm4b), NM_025717 mRNA. 6836854 0.586241 0.007672 Arhgap39 Rho GTPase activating protein 39 NM_001168288 (Arhgap39), transcript variant 1, mRNA. 6771693 0.585241 7.34E-05 Si silver (Si), mRNA. NM_021882 6901737 0.5829 1.14E-05 Adh1 alcohol dehydrogenase 1 (class I) (Adh1), NM_007409 mRNA. 6866021 0.571413 0.006568 Adrb2 adrenergic receptor, beta 2 (Adrb2), NM_007420 mRNA. 6925916 0.570205 0.001706 Sfn stratifin (Sfn), mRNA. NM_018754 6999683 0.567235 0.008346 Xcr1 chemokine (C motif) receptor 1 (Xcr1), NM_011798 mRNA. 6906328 0.567059 0.003282 Gucy1a3 guanylate cyclase 1, soluble, alpha 3 NM_021896 (Gucy1a3), mRNA. 6933600 0.566733 0.004046 Myo1h myosin 1H (Myo1h), mRNA. NM_001164573 6916540 0.565005 0.001106 Pik3r3 phosphatidylinositol 3 kinase, regulatory NM_181585 subunit, polypeptide 3 (p55) (Pik3r3), mRNA. 6990177 0.561956 0.009607 9530091C08Ri RIKEN cDNA 9530091C08 gene NR_033299 k (9530091C08Rik), non-coding RNA. 6829360 0.559632 0.002258 Ank progressive ankylosis (Ank), mRNA. NM_020332 6963558 0.558877 0.006419 Arntl aryl hydrocarbon receptor nuclear NM_007489 translocator-like (Arntl), mRNA. 6871627 0.556732 0.00054 Dtx4 deltex 4 homolog (Drosophila) (Dtx4), NM_172442 mRNA. 6751103 0.551553 0.000144 Ccl20 chemokine (C-C motif) ligand 20 (Ccl20), NM_016960 transcript variant 1, mRNA. 6972557 0.551503 0.007385 Olfr1347 olfactory receptor 1347 (Olfr1347), mRNA. NM_146385

6970203 0.544706 0.003322 Olfr697 olfactory receptor 697 (Olfr697), mRNA. NM_146599 6829588 0.540558 0.004018 Tas2r119 taste receptor, type 2, member 119 NM_020503 (Tas2r119), mRNA. 6855018 0.529459 0.003134 H2-Aa histocompatibility 2, class II antigen A, NM_010378 alpha (H2-Aa), mRNA. 6784343 0.526484 0.001253 Rundc3a RUN domain containing 3A (Rundc3a), NM_016759 mRNA. 6779264 0.526413 0.005423 Peli1 pellino 1 (Peli1), mRNA. NM_023324 6984420 0.525329 0.001263 Bbs2 Bardet-Biedl syndrome 2 (human) (Bbs2), NM_026116 mRNA. 6999555 0.524703 0.000409 Cyp8b1 cytochrome P450, family 8, subfamily b, NM_010012 polypeptide 1 (Cyp8b1), mRNA. 6919003 0.519583 0.007827 Tnfrsf25 tumor necrosis factor receptor superfamily, NM_033042 member 25 (Tnfrsf25), mRNA.

6789274 0.518575 0.008153 Chd3 chromodomain helicase DNA binding NM_146019 protein 3 (Chd3), mRNA. 6811061 0.517967 0.000466 Actn2 actinin alpha 2 (Actn2), mRNA. NM_033268 6845911 0.505062 0.0035 Zdhhc23 zinc finger, DHHC domain containing 23 NM_001007460 (Zdhhc23), mRNA. 6833140 0.503596 0.009281 B430209F14Ri 4 days neonate male adipose cDNA, AK080921 k RIKEN full-length enriched library, clone:B430209F14 product:hypothetical protein, full insert sequence. 6969837 0.501745 0.000374 P2ry6 pyrimidinergic receptor P2Y, G-protein NM_183168 coupled, 6 (P2ry6), mRNA. 6888609 0.501492 0.009498 Olfr1226 olfactory receptor 1226 (Olfr1226), mRNA. NM_146967

6994792 0.497061 0.007785 Olfr959 olfactory receptor 959 (Olfr959), mRNA. NM_146508 6843500 0.488625 0.001379 Pcp4 Purkinje cell protein 4 (Pcp4), mRNA. NM_008791 6880718 0.487494 0.000879 Sqrdl sulfide quinone reductase-like (yeast) NM_021507 (Sqrdl), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6905897 0.487415 0.000538 B3galnt1 UDP-GalNAc:betaGlcNAc beta 1,3- NM_020026 galactosaminyltransferase, polypeptide 1 (B3galnt1), mRNA. 6904545 0.484076 0.005502 1700034I23Rik RIKEN cDNA 1700034I23 gene, mRNA BC117739 (cDNA clone MGC:143484 IMAGE:40090015), complete cds. 6796415 0.482766 0.008525 4933426M11Ri RIKEN cDNA 4933426M11 gene, mRNA BC040401 k (cDNA clone MGC:28532 IMAGE:4193723), complete cds. 6957758 0.4806 0.004298 Art4 ADP-ribosyltransferase 4 (Art4), mRNA. NM_026639 7018507 0.479983 0.002016 P2ry4 pyrimidinergic receptor P2Y, G-protein NM_020621 coupled, 4 (P2ry4), mRNA. 6751264 0.476701 0.000128 Psmd1 proteasome (prosome, macropain) 26S NM_027357 subunit, non-ATPase, 1 (Psmd1), mRNA.

6835454 0.47607 0.000171 Kcnv1 potassium channel, subfamily V, member 1 NM_026200 (Kcnv1), mRNA. 6989086 0.471186 5.37E-05 Arhgap20 Rho GTPase activating protein 20 NM_175535 (Arhgap20), mRNA. 6751339 0.471023 0.002892 Neu2 neuraminidase 2 (Neu2), transcript variant NM_001160163 1, mRNA. 6835973 0.470705 0.005863 Tmem65 transmembrane protein 65 (Tmem65), NM_175212 mRNA. 6960516 0.469661 0.000944 Tmem86a transmembrane protein 86A (Tmem86a), NM_026436 mRNA. 6782915 0.46701 0.000539 Ccl2 chemokine (C-C motif) ligand 2 (Ccl2), NM_011333 mRNA. 6831687 0.465082 0.000309 Kifc2 kinesin family member C2 (Kifc2), mRNA. NM_010630

6753536 0.462603 0.006779 A130050O07R Putative uncharacterized protein ENSMUST00000054333 ik gene:ENSMUSG00000051480 6963178 0.462159 0.003876 Olfr678 olfactory receptor 678 (Olfr678), mRNA. NM_146758 6926987 0.460175 0.003657 Spsb1 splA/ryanodine receptor domain and SOCS NM_029035 box containing 1 (Spsb1), mRNA.

6871062 0.460049 0.006032 Npas4 neuronal PAS domain protein 4 (Npas4), NM_153553 mRNA. 6906972 0.457713 0.003425 Smcp sperm mitochondria-associated cysteine- NM_008574 rich protein (Smcp), nuclear gene encoding mitochondrial protein, mRNA. 7015941 0.457499 0.00996 Slc9a7 solute carrier family 9 (sodium/hydrogen NM_177353 exchanger), member 7 (Slc9a7), mRNA. 6961012 0.456193 0.001434 Magel2 melanoma antigen, family L, 2 (Magel2), NM_013779 mRNA. 6880577 0.455481 0.001459 Ganc glucosidase, alpha; neutral C (Ganc), NM_172672 mRNA. 6824768 0.455088 0.00094 Homez homeodomain leucine zipper-encoding NM_001177705 gene (Homez), transcript variant 1, mRNA.

6792942 0.45481 0.0071 Dtnb dystrobrevin, beta (Dtnb), transcript variant NR_027869 3, non-coding RNA. 6859441 0.452978 0.000431 9530053H22 adult male urinary bladder cDNA, RIKEN AK035476 full-length enriched library, clone:9530053H22 product:hypothetical Histidine-rich region profile/Threonine-rich region profile containing protein, full insert sequence. 6782311 0.443476 0.00488 Olfr390 olfactory receptor 390 (Olfr390), mRNA. NM_146347 6803268 0.436452 0.002374 Serpina11 serine (or cysteine) peptidase inhibitor, NM_199314 clade A (alpha-1 antiproteinase, antitrypsin), member 11 (Serpina11), transcript variant 1, mRNA. 6970857 0.427172 0.005262 Gprc5b G protein-coupled receptor, family C, group NM_022420 5, member B (Gprc5b), transcript variant 2, mRNA. 6802185 0.409799 0.00098 Adam21 a disintegrin and metallopeptidase domain NM_020330 21 (Adam21), mRNA. 6992224 0.406241 0.008935 Hyal1 hyaluronoglucosaminidase 1 (Hyal1), NM_008317 mRNA. 6844301 0.405828 0.00463 Car15 carbonic anhydrase 15 (Car15), mRNA. NM_030558 6908032 0.402787 0.002368 Ubl4b ubiquitin-like 4B (Ubl4b), mRNA. NM_026261 6811806 0.401719 0.003963 Nrsn1 neurensin 1 (Nrsn1), mRNA. NM_009513 6914009 0.399729 0.009414 Orm2 orosomucoid 2 (Orm2), mRNA. NM_011016 6876238 0.399432 0.002854 Angptl2 angiopoietin-like 2 (Angptl2), mRNA. NM_011923 6925435 0.395626 0.007572 Gjb5 gap junction protein, beta 5 (Gjb5), mRNA. NM_010291

6854788 0.390469 0.006214 Tff2 trefoil factor 2 (spasmolytic protein 1) NM_009363 (Tff2), mRNA. 6789483 0.388156 0.000428 6330403K07Ri RIKEN cDNA 6330403K07 gene NM_134022 k (6330403K07Rik), mRNA. 6783033 0.385935 0.001408 E230016K23Ri RIKEN cDNA E230016K23 gene NR_036452 k (E230016K23Rik), transcript variant 1, non- coding RNA. 6956852 0.385073 0.003518 Fxyd4 FXYD domain-containing ion transport NM_033648 regulator 4 (Fxyd4), transcript variant 1, mRNA. 6831609 0.380923 0.007056 Tigd5 tigger transposable element derived 5 NM_178646 (Tigd5), mRNA. 6873309 0.379154 0.0051 Pdzd7 PDZ domain containing 7 (Pdzd7), mRNA. NM_001195265

6849968 0.376569 0.00704 H2-Eb1 histocompatibility 2, class II antigen E beta NM_010382 (H2-Eb1), mRNA. 6814348 0.370602 0.001551 Slc6a19 solute carrier family 6 (neurotransmitter NM_028878 transporter), member 19 (Slc6a19), mRNA. 6782129 0.368486 0.000574 Tm4sf5 transmembrane 4 superfamily member 5 NM_029360 (Tm4sf5), mRNA. 6818088 0.368077 0.001906 Prrxl1 paired related homeobox protein-like 1 NM_001001796 (Prrxl1), mRNA. 6999673 0.367369 0.000437 Slc6a20b solute carrier family 6 (neurotransmitter NM_011731 transporter), member 20B (Slc6a20b), mRNA. 6856201 0.367056 0.001074 Plin4 perilipin 4 (Plin4), mRNA. NM_020568 6970207 0.363064 0.003573 Olfr700 olfactory receptor 700 (Olfr700), mRNA. NM_146600 6979702 0.361921 0.005083 Mc1r melanocortin 1 receptor (Mc1r), mRNA. NM_008559 6963065 0.361324 0.009305 Olfr556 olfactory receptor 556 (Olfr556), mRNA. NM_146754 6828657 0.360862 0.001542 Ugt3a2 UDP glycosyltransferases 3 family, NM_144845 polypeptide A2 (Ugt3a2), mRNA. 6803946 0.360241 8.81E-05 Srsf10 serine/arginine-rich splicing factor 10 NM_010178 (Srsf10), transcript variant 1, mRNA. 6890838 0.358853 0.009843 Il1b interleukin 1 beta (Il1b), mRNA. NM_008361 6961795 0.358788 0.004972 Agbl1 cytosolic carboxypeptidase 4 mRNA, DQ867033 complete cds. 6922471 0.358617 0.008011 Dbc1 deleted in bladder cancer 1 (human) NM_019967 (Dbc1), mRNA. 6758139 0.357298 0.001098 Mfsd9 major facilitator superfamily domain NM_172499 containing 9 (Mfsd9), mRNA. 6848972 0.354806 0.008411 Fpr2 formyl peptide receptor 2 (Fpr2), mRNA. NM_008039 6942395 0.352881 0.001886 Wbscr28 Williams-Beuren syndrome chromosome NM_029681 region 28 (human) (Wbscr28), transcript variant 2, mRNA. 6866862 0.352198 0.005036 Setbp1 SET binding protein 1 (Setbp1), mRNA. NM_053099 6854446 0.346443 0.00682 Rhbdl1 rhomboid, veinlet-like 1 (Drosophila) NM_144816 (Rhbdl1), mRNA. 6788679 0.343461 0.003854 Olfr223 olfactory receptor 223 (Olfr223), mRNA. NM_146429 6868902 0.337555 0.003673 Kcnv2 potassium channel, subfamily V, member 2 NM_183179 (Kcnv2), mRNA. 6829661 0.331879 0.005336 BC030476 cDNA sequence BC030476 (BC030476), NM_173421 mRNA. 6968875 0.330087 0.009479 Bnc1 basonuclin 1 (Bnc1), mRNA. NM_007562 6970496 0.328796 0.003682 Dkk3 dickkopf homolog 3 (Xenopus laevis) NM_015814 (Dkk3), mRNA. 6949007 0.327622 0.005611 Lmcd1 LIM and cysteine-rich domains 1 (Lmcd1), NM_144799 mRNA. 6872828 0.326416 0.0059 Htr7 5-hydroxytryptamine (serotonin) receptor 7 NM_008315 (Htr7), mRNA. 6858260 0.325709 0.009333 Mas1 MAS1 oncogene (Mas1), mRNA. NM_008552 6910597 0.321814 0.005337 Ptgfr prostaglandin F receptor (Ptgfr), mRNA. NM_008966 6829910 0.317416 0.008584 Odf1 outer dense fiber of sperm tails 1 (Odf1), NM_008757 mRNA. 6768572 0.315835 0.004392 Tmem26 transmembrane protein 26 (Tmem26), NM_177794 mRNA. 6917816 0.309022 0.003469 Tcea3 transcription elongation factor A (SII), 3 NM_011542 (Tcea3), mRNA. 6885385 0.308398 0.002811 2310002J15Ri RIKEN cDNA 2310002J15 gene NM_026415 k (2310002J15Rik), mRNA. 6964380 0.30813 0.000997 Itgam integrin alpha M (Itgam), transcript variant NM_001082960 1, mRNA. 6865723 0.307522 0.006806 3-Mar membrane-associated ring finger (C3HC4) NM_177115 3 (March3), mRNA. 6996308 0.307214 0.005752 Slc24a1 solute carrier family 24 NM_144813 (sodium/potassium/calcium exchanger), member 1 (Slc24a1), mRNA. 6949593 0.302212 0.001193 Slc6a12 solute carrier family 6 (neurotransmitter NM_133661 transporter, betaine/GABA), member 12 (Slc6a12), mRNA. 6922966 0.302194 0.007699 Bnc2 basonuclin 2 (Bnc2), mRNA. NM_172870 6800020 0.301735 0.001573 Hdac9 histone deacetylase 9 (Hdac9), mRNA. NM_024124 6913039 0.297625 0.002862 Reck reversion-inducing-cysteine-rich protein NM_016678 with kazal motifs (Reck), mRNA. 6918131 0.295065 0.00671 Mfap2 microfibrillar-associated protein 2 (Mfap2), NM_008546 transcript variant 1, mRNA. 6789161 0.294763 0.001849 Glp2r glucagon-like peptide 2 receptor (Glp2r), NM_175681 mRNA. 6881139 0.293622 0.001798 Sirpa signal-regulatory protein alpha (Sirpa), NM_001177646 transcript variant 2, mRNA. 7016808 0.287109 0.005242 Hs6st2 heparan sulfate 6-O-sulfotransferase 2 NM_001077202 (Hs6st2), transcript variant 1, mRNA. 6885516 0.285246 0.007937 Tmem8c transmembrane protein 8C (Tmem8c), NM_025376 transcript variant 1, mRNA. 6964259 0.284499 0.003354 Sez6l2 seizure related 6 homolog like 2 (Sez6l2), NM_144926 mRNA. 6754102 0.281419 0.008741 Nmnat2 nicotinamide nucleotide NM_175460 adenylyltransferase 2 (Nmnat2), mRNA. 6890127 0.281341 0.000881 Bmf BCL2 modifying factor (Bmf), mRNA. NM_138313 6798933 0.27676 0.004301 Kcns3 potassium voltage-gated channel, delayed- NM_173417 rectifier, subfamily S, member 3 (Kcns3), transcript variant 1, mRNA. 6836700 0.275612 0.001344 Ly6d lymphocyte antigen 6 complex, locus D NM_010742 (Ly6d), mRNA. 6951054 0.274313 0.009073 Sspn sarcospan (Sspn), mRNA. NM_010656 6946002 0.273753 0.001588 Sspo SCO-spondin (Sspo), mRNA. NM_173428 6885522 0.273702 0.007587 Fam163b family with sequence similarity 163, NM_175427 member B (Fam163b), mRNA. 6850834 0.270787 0.002384 Trem2 triggering receptor expressed on myeloid NM_031254 cells 2 (Trem2), mRNA. 6959096 0.266198 0.002125 Zfp235 zinc finger protein 235 (Zfp235), mRNA. NM_019941 6817954 0.265037 0.002775 Mustn1 musculoskeletal, embryonic nuclear protein NM_181390 1 (Mustn1), mRNA. 6875649 0.263645 0.002704 Il1rn interleukin 1 receptor antagonist (Il1rn), NM_031167 transcript variant 1, mRNA. 6838666 0.262472 0.00619 Krt72-ps keratin 72, pseudogene (Krt72-ps), mRNA. NM_213728

6817694 0.259551 4.29E-05 Il17rd interleukin 17 receptor D (Il17rd), mRNA. NM_134437 6849762 0.257146 0.006658 Glp1r glucagon-like peptide 1 receptor (Glp1r), NM_021332 mRNA. 6750555 0.256862 0.006051 Plcd4 phospholipase C, delta 4 (Plcd4), transcript NM_148937 variant 2, mRNA. 6972841 0.255758 0.007947 Gm5065 predicted gene 5065 (Gm5065), non- NR_003622 coding RNA. 6877954 0.253749 0.000872 Myo3b myosin IIIB (Myo3b), mRNA. NM_177376 6935717 0.253233 0.009848 4930434E21Ri RIKEN cDNA 4930434E21 gene NM_029440 k (4930434E21Rik), mRNA. 6953145 0.251557 0.007196 Fam115a family with sequence similarity 115, NM_029930 member A (Fam115a), mRNA. 6772864 0.248952 0.003519 Tmem200a transmembrane protein 200A NM_029881 (Tmem200a), mRNA. 6965885 0.2467 0.006306 Cd177 CD177 antigen (Cd177), mRNA. NM_026862 6980576 0.246523 0.000525 1700029H14Ri RIKEN cDNA 1700029H14 gene NM_001080781 k (1700029H14Rik), transcript variant 2, mRNA. 6750848 0.246065 0.007469 Sgpp2 sphingosine-1-phosphate phosphotase 2 NM_001004173 (Sgpp2), mRNA. 7015255 0.242176 0.001606 Mid1 midline 1 (Mid1), transcript variant 2, NM_183151 mRNA. 6942558 0.241425 0.008326 Pcolce procollagen C-endopeptidase enhancer NM_008788 protein (Pcolce), mRNA. 6807230 0.235025 0.005943 Slc34a1 solute carrier family 34 (sodium NM_011392 phosphate), member 1 (Slc34a1), mRNA.

6936719 0.234986 0.001983 Kcnh2 potassium voltage-gated channel, NM_013569 subfamily H (eag-related), member 2 (Kcnh2), mRNA. 6823797 0.234977 0.000962 Chat choline acetyltransferase (Chat), mRNA. NM_009891 6890356 0.233718 0.001031 Epb4.2 erythrocyte protein band 4.2 (Epb4.2), NM_013513 mRNA. 6820015 0.233217 0.004011 Nkx2-6 NK2 transcription factor related, locus 6 NM_010920 (Drosophila) (Nkx2-6), mRNA. 6835429 0.230008 0.00328 Sybu syntabulin (syntaxin-interacting) (Sybu), NM_176998 transcript variant a, mRNA. 6883132 0.228811 0.00228 Cd40 CD40 antigen (Cd40), transcript variant 3, NR_027852 non-coding RNA. 6953098 0.227578 0.002142 Trpv6 transient receptor potential cation channel, NM_022413 subfamily V, member 6 (Trpv6), mRNA.

6747478 0.226862 0.008422 3110035E14Ri RIKEN cDNA 3110035E14 gene, mRNA BC066997 k (cDNA clone MGC:91354 IMAGE:5703513), complete cds. 6762353 0.225979 0.004572 Adora1 adenosine A1 receptor (Adora1), transcript NM_001008533 variant 1, mRNA. 6789347 0.225341 0.006424 4933402P03Ri RIKEN cDNA 4933402P03 gene, mRNA BC137961 k (cDNA clone MGC:169585 IMAGE:8860980), complete cds. 6814347 0.224001 0.002518 Slc6a18 solute carrier family 6 (neurotransmitter NM_001040692 transporter), member 18 (Slc6a18), transcript variant 1, mRNA. 6866653 0.223861 0.003647 Mapk4 mitogen-activated protein kinase 4 NM_172632 (Mapk4), mRNA. 6853905 0.218427 0.008375 Wdr27 WD repeat domain 27 (Wdr27), mRNA. NM_175173 6956964 0.216025 0.005164 Cecr6 cat eye syndrome chromosome region, NM_033567 candidate 6 homolog (human) (Cecr6), mRNA. 6857809 0.214676 0.008368 Abcg5 ATP-binding cassette, sub-family G NM_031884 (WHITE), member 5 (Abcg5), mRNA. 6866006 0.213965 0.008959 Ablim3 actin binding LIM protein family, member 3 NM_198649 (Ablim3), transcript variant 1, mRNA. 6848479 0.210602 0.002 Zdhhc14 zinc finger, DHHC domain containing 14 NM_146073 (Zdhhc14), mRNA. 6870580 0.209916 0.006993 Tcf7l2 transcription factor 7-like 2, T-cell specific, NM_001142918 HMG-box (Tcf7l2), transcript variant 1, mRNA. 6961912 0.209751 0.001541 Acan aggrecan (Acan), mRNA. NM_007424 6752988 0.207951 0.003988 AA986860 expressed sequence AA986860 NM_177604 (AA986860), mRNA. 6825132 0.207456 0.004142 Atp8a2 ATPase, aminophospholipid transporter- NM_015803 like, class I, type 8A, member 2 (Atp8a2), mRNA. 6991326 0.206943 0.000356 Zic4 zinc finger protein of the cerebellum 4 NM_009576 (Zic4), mRNA. 6785644 0.206872 0.000287 Ccdc157 coiled-coil domain containing 157 NM_177616 (Ccdc157), transcript variant 2, mRNA. 6789969 0.205519 0.00091 Sarm1 sterile alpha and HEAT/Armadillo motif NM_001168521 containing 1 (Sarm1), transcript variant 1, mRNA. 6879022 0.201423 0.008731 Mybpc3 myosin binding protein C, cardiac NM_008653 (Mybpc3), mRNA. 6867715 0.200646 0.001927 Rin1 Ras and Rab interactor 1 (Rin1), mRNA. NM_145495 6805134 0.199847 0.004998 Sfrp4 secreted frizzled-related protein 4 (Sfrp4), NM_016687 mRNA. 6837582 0.197971 0.005448 Wnt7b wingless-related MMTV integration site 7B NM_009528 (Wnt7b), transcript variant 1, mRNA. 6785079 0.194314 0.001045 Ttyh2 tweety homolog 2 (Drosophila) (Ttyh2), NM_053273 mRNA. 6917774 0.191516 0.00437 Il22ra1 interleukin 22 receptor, alpha 1 (Il22ra1), NM_178257 mRNA. 6909941 0.189121 0.001734 Bmpr1b bone morphogenetic protein receptor, type NM_007560 1B (Bmpr1b), mRNA. 6966808 0.188621 0.006131 Cd33 CD33 antigen (Cd33), transcript variant 1, NM_001111058 mRNA. 6975879 0.184032 0.003032 Lrp2bp Lrp2 binding protein (Lrp2bp), mRNA. NM_026278 6785631 0.183855 0.005573 Slc35e4 solute carrier family 35, member E4 NM_153142 (Slc35e4), mRNA. 6875459 0.180554 0.001896 Etl4 enhancer trap locus 4 (Etl4), transcript NM_001177631 variant e, mRNA. 6976210 0.179871 0.009109 Asb5 ankyrin repeat and SOCs box-containing 5 NM_029569 (Asb5), mRNA. 6747871 0.179226 0.008885 Crispld1 cysteine-rich secretory protein LCCL NM_031402 domain containing 1 (Crispld1), mRNA. 6974220 0.176688 0.003821 Dlgap2 discs, large (Drosophila) homolog- NM_172910 associated protein 2 (Dlgap2), transcript variant 1, mRNA. 6978309 0.1724 0.004261 Slc12a3 solute carrier family 12, member 3 NM_019415 (Slc12a3), mRNA. 6991267 0.171815 0.007969 Adamts7 a disintegrin-like and metallopeptidase NM_001003911 (reprolysin type) with thrombospondin type 1 motif, 7 (Adamts7), mRNA. 6937056 0.171763 0.006545 Slc5a6 solute carrier family 5 (sodium-dependent NM_177870 vitamin transporter), member 6 (Slc5a6), transcript variant 2, mRNA. 6750143 0.170134 0.008677 Unc80 unc-80 homolog (C. elegans) (Unc80), NM_175510 mRNA. 6953611 0.167198 0.004197 Hoxa7 homeobox A7 (Hoxa7), mRNA. NM_010455 6926324 0.153406 0.009856 Htr6 5-hydroxytryptamine (serotonin) receptor 6 NM_021358 (Htr6), mRNA. 6934568 0.148567 0.002208 Piwil1 piwi-like homolog 1 (Drosophila) (Piwil1), NM_021311 mRNA. 6775838 0.147492 0.005612 Dram1 DNA-damage regulated autophagy NM_027878 modulator 1 (Dram1), mRNA. 6939057 0.147345 0.007276 Corin corin (Corin), transcript variant 1, mRNA. NM_016869 6764138 0.147121 0.004952 Atp1a2 ATPase, Na+/K+ transporting, alpha 2 NM_178405 polypeptide (Atp1a2), mRNA. 6988213 0.144702 0.000776 Robo4 roundabout homolog 4 (Drosophila) NM_028783 (Robo4), mRNA. 6785123 0.127098 0.009669 Otop3 otopetrin 3 (Otop3), mRNA. NM_027132 6988741 0.125402 0.009243 Bace1 beta-site APP cleaving enzyme 1 (Bace1), NM_011792 transcript variant 1, mRNA. 6751699 0.12496 0.008438 Farp2 FERM, RhoGEF and pleckstrin domain NM_145519 protein 2 (Farp2), mRNA. 6926896 0.085951 0.009902 Ptchd2 patched domain containing 2 (Ptchd2), NM_001083342 mRNA. 6802313 -0.10104 0.008856 Fam161b family with sequence similarity 161, BC062132 member B, mRNA (cDNA clone MGC:69959 IMAGE:6509090), complete cds. 6781927 -0.1074 0.00647 Pik3r6 phosphoinositide-3-kinase, regulatory NM_001081566 subunit 6 (Pik3r6), transcript variant 1, mRNA. 6803821 -0.11497 0.00976 Cdc42bpb CDC42 binding protein kinase beta NM_183016 (Cdc42bpb), mRNA. 6822485 -0.12782 0.007507 4930452B06Ri RIKEN cDNA 4930452B06 gene NM_028934 k (4930452B06Rik), mRNA. 6833146 -0.15489 0.001084 Prph peripherin (Prph), transcript variant 1, NM_013639 mRNA. 6833110 -0.15645 0.008522 Ccdc65 coiled-coil domain containing 65 (Ccdc65), NM_153518 mRNA. 6827198 -0.16326 0.009601 Pou4f1 POU domain, class 4, transcription factor 1 NM_011143 (Pou4f1), mRNA. 6980546 -0.16498 0.00666 Adprhl1 ADP-ribosylhydrolase like 1 (Adprhl1), NM_172750 mRNA. 6819032 -0.16547 0.004332 E130112L23Ri RIKEN cDNA E130112L23 gene NM_198249 k (E130112L23Rik), transcript variant 1, mRNA. 6986031 -0.16674 0.00866 Acta1 actin, alpha 1, skeletal muscle (Acta1), NM_009606 mRNA. 6790774 -0.17015 0.00347 Tom1l1 target of myb1-like 1 (chicken) (Tom1l1), NM_028011 mRNA. 6823105 -0.17674 0.001281 Usp54 ubiquitin specific peptidase 54 (Usp54), NM_030180 mRNA. 6788375 -0.17971 0.006344 Lyrm7 LYR motif containing 7 (Lyrm7), mRNA. NM_029327 6813070 -0.18084 0.00178 Ptpdc1 protein tyrosine phosphatase domain NM_207232 containing 1 (Ptpdc1), mRNA. 6803028 -0.18736 0.007389 Ptpn21 protein tyrosine phosphatase, non-receptor NM_011877 type 21 (Ptpn21), transcript variant 1, mRNA. 6929653 -0.18806 0.003322 Emilin1 elastin microfibril interfacer 1 (Emilin1), NM_133918 mRNA. 6811776 -0.191 0.006934 Aldh5a1 aldhehyde dehydrogenase family 5, NM_172532 subfamily A1 (Aldh5a1), mRNA. 6882612 -0.19338 0.003855 4921517L17Ri RIKEN cDNA 4921517L17 gene, mRNA BC140978 k (cDNA clone MGC:175939 IMAGE:9055590), complete cds. 6966203 -0.1949 0.007421 Sipa1l3 signal-induced proliferation-associated 1 NM_001081028 like 3 (Sipa1l3), mRNA. 6795260 -0.20317 0.006832 Insm2 insulinoma-associated 2 (Insm2), mRNA. NM_020287

6769139 -0.20341 0.002884 Hcn2 hyperpolarization-activated, cyclic NM_008226 nucleotide-gated K+ 2 (Hcn2), mRNA. 7011938 -0.20553 0.004767 Dusp9 dual specificity phosphatase 9 (Dusp9), NM_029352 mRNA. 6876219 -0.20638 0.002162 Ptrh1 peptidyl-tRNA hydrolase 1 homolog (S. NM_178595 cerevisiae) (Ptrh1), mRNA. 6877588 -0.20872 0.008379 Tbr1 T-box brain gene 1 (Tbr1), mRNA. NM_009322 6786045 -0.21022 0.006613 Ddc dopa decarboxylase (Ddc), transcript NM_001190448 variant 1, mRNA. 6918763 -0.21409 0.005007 Dffa DNA fragmentation factor, alpha subunit NM_001025296 (Dffa), transcript variant 1, mRNA. 6994678 -0.21489 0.005679 Slc37a2 solute carrier family 37 (glycerol-3- NM_001145960 phosphate transporter), member 2 (Slc37a2), transcript variant 1, mRNA. 6792419 -0.21746 0.008951 Fdxr ferredoxin reductase (Fdxr), nuclear gene NM_007997 encoding mitochondrial protein, mRNA.

6974082 -0.21861 0.006048 Sox1 SRY-box containing gene 1 (Sox1), mRNA. NM_009233

6817287 -0.21998 0.002553 Nid2 nidogen 2 (Nid2), mRNA. NM_008695 6885022 -0.22073 0.007945 2810030E01Ri RIKEN cDNA 2810030E01 gene NM_028317 k (2810030E01Rik), mRNA. 6957138 -0.22104 0.003328 Leprel2 leprecan-like 2 (Leprel2), mRNA. NM_013534 6890979 -0.22253 0.008924 Gfra4 glial cell line derived neurotrophic factor NM_020014 family receptor alpha 4 (Gfra4), transcript variant 2, mRNA. 6960423 -0.22506 0.009525 Tmem143 transmembrane protein 143 (Tmem143), NM_144801 mRNA. 6796158 -0.22877 0.001652 Syne2 synaptic nuclear envelope 2 (Syne2), NM_001005510 mRNA. 6965038 -0.23155 0.009355 Lrrc27 leucine rich repeat containing 27 (Lrrc27), NM_027164 transcript variant 1, mRNA. 6792416 -0.23315 0.002421 Nat9 N-acetyltransferase 9 (GCN5-related, NM_025400 putative) (Nat9), mRNA. 6995065 -0.23477 0.003862 Nlrx1 NLR family member X1 (Nlrx1), transcript NM_001163743 variant 1, mRNA. 6769309 -0.23506 0.005363 Ankrd24 ankyrin repeat domain 24 (Ankrd24), NM_027480 mRNA. 6848018 -0.2351 0.008314 Setd4 SET domain containing 4 (Setd4), mRNA. NM_145482

6959868 -0.23598 0.001992 Tshz3 teashirt zinc finger family member 3 NM_172298 (Tshz3), mRNA. 6909796 -0.23772 0.002885 Mttp microsomal triglyceride transfer protein NM_001163457 (Mttp), transcript variant 1, mRNA. 6780521 -0.23968 0.009344 Sox30 SRY-box containing gene 30 (Sox30), NM_173384 mRNA. 6774738 -0.24004 0.002052 1700040L02Ri RIKEN cDNA 1700040L02 gene, mRNA BC087900 k (cDNA clone MGC:107218 IMAGE:6774064), complete cds. 6969639 -0.24625 0.001268 Myo7a myosin VIIA (Myo7a), mRNA. NM_008663 6836779 -0.24635 0.002889 Eef1d eukaryotic translation elongation factor 1 NM_029663 delta (guanine nucleotide exchange protein) (Eef1d), transcript variant 1, mRNA. 6823221 -0.24677 0.007955 Comtd1 catechol-O-methyltransferase domain NM_026965 containing 1 (Comtd1), mRNA. 6955259 -0.25385 0.001547 Antxr1 anthrax toxin receptor 1 (Antxr1), mRNA. NM_054041

6854340 -0.25728 0.004831 Tbc1d24 TBC1 domain family, member 24 NM_001163852 (Tbc1d24), transcript variant 7, mRNA. 6938797 -0.25894 0.004036 Apbb2 amyloid beta (A4) precursor protein- NM_009686 binding, family B, member 2 (Apbb2), mRNA. 6979716 -0.25905 0.007745 Gas8 growth arrest specific 8 (Gas8), mRNA. NM_018855 6956981 -0.25955 0.007429 Bid BH3 interacting domain death agonist NM_007544 (Bid), mRNA. 6750595 -0.26059 0.000438 Zfand2b zinc finger, AN1 type domain 2B (Zfand2b), NM_026846 transcript variant 1, mRNA. 6793226 -0.26457 0.00766 Sdc1 syndecan 1 (Sdc1), mRNA. NM_011519 6917549 -0.2652 0.003646 Fgr Gardner-Rasheed feline sarcoma viral NM_010208 (Fgr) oncogene homolog (Fgr), mRNA. 6873360 -0.26751 0.003939 Poll polymerase (DNA directed), lambda (Poll), NM_020032 mRNA. 6775457 -0.26809 0.007032 Hmg20b high mobility group 20 B (Hmg20b), NM_010440 transcript variant 1, mRNA. 6919063 -0.27013 0.001301 Wdr8 WD repeat domain 8 (Wdr8), mRNA. NM_021499 6786586 -0.27133 0.003703 Ehbp1 EH domain binding protein 1 (Ehbp1), NM_153078 mRNA. 6768005 -0.27133 0.00276 Msl3l2 male-specific lethal 3-like 2 (Drosophila) NM_001163833 (Msl3l2), mRNA. 6871374 -0.27217 0.004344 Taf6l TAF6-like RNA polymerase II, p300/CBP- NM_001177798 associated factor (PCAF)-associated factor (Taf6l), transcript variant 2, mRNA.

6882474 -0.27266 0.002842 Zfp341 zinc finger protein 341 (Zfp341), mRNA. NM_199304 6837109 -0.27336 0.005494 Kcnj4 potassium inwardly-rectifying channel, NM_008427 subfamily J, member 4 (Kcnj4), mRNA. 6770079 -0.27383 0.009901 4921510H08Ri RIKEN cDNA 4921510H08 gene NM_025724 k (4921510H08Rik), mRNA. 6765533 -0.27591 0.007848 Syne1 synaptic nuclear envelope 1 (Syne1), NM_153399 transcript variant 1, mRNA. 6770661 -0.27694 0.001406 Csrp2 cysteine and glycine-rich protein 2 (Csrp2), NM_007792 mRNA. 6769553 -0.28171 4.86E-05 BC030307 cDNA sequence BC030307 (BC030307), NM_001003910 transcript variant 3, mRNA. 6791501 -0.28267 0.009165 Vat1 vesicle amine transport protein 1 homolog NM_012037 (T californica) (Vat1), mRNA. 6916630 -0.28589 0.001603 Tmem53 transmembrane protein 53 (Tmem53), NM_026837 mRNA. 6850637 -0.28759 0.007772 Aars2 alanyl-tRNA synthetase 2, mitochondrial NM_198608 (putative) (Aars2), nuclear gene encoding mitochondrial protein, mRNA. 6966964 -0.28771 0.002096 Trpm4 transient receptor potential cation channel, NM_175130 subfamily M, member 4 (Trpm4), mRNA.

6946759 -0.28802 0.001742 Prdm5 PR domain containing 5 (Prdm5), mRNA. NM_027547

6964285 -0.29061 0.007109 Mylpf myosin light chain, phosphorylatable, fast NM_016754 skeletal muscle (Mylpf), mRNA. 6789270 -0.29174 0.002081 Cntrob centrobin, centrosomal BRCA2 interacting NM_172560 protein (Cntrob), mRNA. 6790264 -0.29337 0.004525 Pex12 peroxisomal biogenesis factor 12 (Pex12), NM_134025 mRNA. 6892306 -0.29352 0.006745 Necab3 N-terminal EF-hand calcium binding NM_021546 protein 3 (Necab3), mRNA. 6966923 -0.29378 0.000938 Bcl2l12 BCL2-like 12 (proline rich) (Bcl2l12), NM_029410 mRNA. 6881114 -0.29478 0.00902 Ttl tubulin tyrosine ligase (Ttl), mRNA. NM_027192 6816248 -0.29651 0.009927 Itga1 integrin alpha 1 (Itga1), mRNA. NM_001033228 6844558 -0.29724 0.009488 Etv5 ets variant gene 5 (Etv5), mRNA. NM_023794 6787730 -0.29804 0.009528 Lsm11 U7 snRNP-specific Sm-like protein LSM11 NM_028185 (Lsm11), mRNA. 6978855 -0.29891 0.007084 Pard6a par-6 (partitioning defective 6,) homolog NM_001047436 alpha (C. elegans) (Pard6a), transcript variant 3, mRNA. 6775478 -0.3008 0.008787 Tle6 transducin-like enhancer of split 6, NM_053254 homolog of Drosophila E(spl) (Tle6), mRNA. 6813386 -0.30198 0.004067 Mxd3 Max dimerization protein 3 (Mxd3), mRNA. NM_016662

6890985 -0.30258 0.000639 1700037H04Ri RIKEN cDNA 1700037H04 gene, mRNA BC071212 k (cDNA clone IMAGE:4224813), complete cds. 6754700 -0.30431 0.008833 4930455F23Ri RIKEN cDNA 4930455F23 gene NM_029115 k (4930455F23Rik), mRNA. 6979053 -0.30508 0.001751 Pkd1l3 polycystic kidney disease 1 like 3 (Pkd1l3), NM_001039700 transcript variant 1, mRNA. 6840604 -0.30607 0.000397 Lmln leishmanolysin-like (metallopeptidase M8 NM_172823 family) (Lmln), mRNA. 6876405 -0.30983 0.00274 Dab2ip disabled homolog 2 (Drosophila) NM_001114124 interacting protein (Dab2ip), transcript variant 2, mRNA. 6749473 -0.3113 0.007261 Osgepl1 O-sialoglycoprotein endopeptidase-like 1 NM_028091 (Osgepl1), mRNA. 6917131 -0.31339 0.005483 Fam176b family with sequence similarity 176, BC029204 member B, mRNA (cDNA clone MGC:36197 IMAGE:3964022), complete cds. 6989152 -0.31347 0.000156 Kdelc2 KDEL (Lys-Asp-Glu-Leu) containing 2 NM_212445 (Kdelc2), mRNA. 6882264 -0.31431 7.82E-05 Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) NM_029688 (Srxn1), mRNA. 6926975 -0.31474 0.006 Tmem201 transmembrane protein 201 (Tmem201), NM_001025106 transcript variant 1, mRNA. 6900191 -0.31913 0.009654 Ppm1j protein phosphatase 1J (Ppm1j), mRNA. NM_027982 6993717 -0.32067 6.33E-05 Angptl6 angiopoietin-like 6 (Angptl6), mRNA. NM_145154 6796597 -0.32326 0.008633 Coq6 coenzyme Q6 homolog (yeast) (Coq6), NM_172582 nuclear gene encoding mitochondrial protein, mRNA. 6788653 -0.32418 0.008787 A230051G13R RIKEN cDNA A230051G13 gene NM_173785 ik (A230051G13Rik), mRNA. 6893303 -0.32462 0.00435 Zfp64 zinc finger protein 64 (Zfp64), mRNA. NM_009564 6861137 -0.32611 0.000965 1700065I17Rik RIKEN cDNA 1700065I17 gene, mRNA BC099538 (cDNA clone MGC:118202 IMAGE:30916077), complete cds. 6798315 -0.32857 0.006081 4930427A07Ri RIKEN cDNA 4930427A07 gene NM_134041 k (4930427A07Rik), mRNA. 6788128 -0.32939 0.006288 N4bp3 NEDD4 binding protein 3 (N4bp3), mRNA. NM_145974

6836962 -0.32958 0.000277 Apol10b apolipoprotein L 10b (Apol10b), mRNA. NM_177820 6811554 -0.32989 0.002451 Prss16 protease, serine, 16 (thymus) (Prss16), NM_019429 mRNA. 6985942 -0.33031 0.004389 Aprt adenine phosphoribosyl transferase (Aprt), NM_009698 mRNA. 6766250 -0.33082 0.002617 Txlnb taxilin beta (Txlnb), mRNA. NM_138628 6771050 -0.33152 0.003909 Mdm1 transformed mouse 3T3 cell double minute NM_001162904 1 (Mdm1), transcript variant 3, mRNA.

6790684 -0.33175 0.004754 Pctp phosphatidylcholine transfer protein (Pctp), NM_008796 mRNA. 6968828 -0.33232 3.59E-05 Cpeb1 cytoplasmic polyadenylation element NM_007755 binding protein 1 (Cpeb1), mRNA. 6750557 -0.33288 0.00766 Bcs1l BCS1-like (yeast) (Bcs1l), nuclear gene NM_025784 encoding mitochondrial protein, mRNA. 6849622 -0.3331 0.000382 Fgd2 FYVE, RhoGEF and PH domain containing NM_001159538 2 (Fgd2), transcript variant 1, mRNA.

6925559 -0.33311 0.00519 Zbtb8a zinc finger and BTB domain containing 8a NM_028603 (Zbtb8a), mRNA. 6820563 -0.33377 0.008548 Mtrf1 mitochondrial translational release factor 1 NM_145960 (Mtrf1), nuclear gene encoding mitochondrial protein, mRNA. 6933598 -0.33479 0.002242 Ung uracil DNA glycosylase (Ung), transcript NM_001040691 variant 1, mRNA. 6855123 -0.3358 0.001019 Ddr1 discoidin domain receptor family, member NM_007584 1 (Ddr1), transcript variant 1, mRNA.

6984909 -0.3359 0.008365 Cmtm4 CKLF-like MARVEL transmembrane NM_153582 domain containing 4 (Cmtm4), mRNA. 6838808 -0.33632 0.000808 Zfp385a zinc finger protein 385A (Zfp385a), mRNA. NM_013866

6946102 -0.33674 0.000731 D330028D13R RIKEN cDNA D330028D13 gene NM_172727 ik (D330028D13Rik), transcript variant 1, mRNA. 6908088 -0.33678 0.004419 Gstm4 glutathione S-transferase, mu 4 (Gstm4), NM_026764 transcript variant 1, mRNA. 6873503 -0.33712 0.006365 Sh3pxd2a SH3 and PX domains 2A (Sh3pxd2a), NM_008018 transcript variant 1, mRNA. 6813560 -0.33994 0.004651 Gkap1 G kinase anchoring protein 1 (Gkap1), NM_019832 mRNA. 6959595 -0.34036 0.000542 Hspb6 heat shock protein, alpha-crystallin-related, NM_001012401 B6 (Hspb6), mRNA. 6831592 -0.34041 0.000121 Zfp41 zinc finger protein 41 (Zfp41), transcript NM_011759 variant 1, mRNA. 6969890 -0.34059 0.002801 Lrrc51 leucine rich repeat containing 51 (Lrrc51), NM_001162974 transcript variant 3, mRNA. 6817334 -0.34193 0.001024 Nudt13 nudix (nucleoside diphosphate linked NM_026341 moiety X)-type motif 13 (Nudt13), mRNA.

6775299 -0.34435 0.004275 Mier2 mesoderm induction early response 1, NM_027422 family member 2 (Mier2), mRNA. 7017600 -0.34492 0.003789 L1cam L1 cell adhesion molecule (L1cam), NM_008478 mRNA. 6949206 -0.34704 0.001219 Tsen2 tRNA splicing endonuclease 2 homolog (S. NM_199033 cerevisiae) (Tsen2), mRNA. 6788791 -0.34815 0.006926 Shmt1 serine hydroxymethyltransferase 1 NM_009171 (soluble) (Shmt1), nuclear gene encoding mitochondrial protein, mRNA. 6850103 -0.35025 0.005178 Ddah2 dimethylarginine dimethylaminohydrolase 2 NM_001190449 (Ddah2), transcript variant 1, mRNA.

6860914 -0.35062 0.001351 Gykl1 glycerol kinase-like 1 (Gykl1), mRNA. NM_010293 6936939 -0.35229 0.008106 Mnx1 motor neuron and pancreas homeobox 1 NM_019944 (Mnx1), mRNA. 7020156 -0.35231 0.007907 Maged2 melanoma antigen, family D, 2 (Maged2), NM_030700 mRNA. 6885969 -0.35233 0.002829 Pbx3 pre B-cell leukemia transcription factor 3 NM_016768 (Pbx3), mRNA. 6789395 -0.35511 0.007681 Slc16a13 solute carrier family 16 (monocarboxylic NM_172371 acid transporters), member 13 (Slc16a13), mRNA. 6854346 -0.35692 0.000136 1600002H07Ri RIKEN cDNA 1600002H07 gene, mRNA BC072612 k (cDNA clone MGC:99862 IMAGE:6414405), complete cds. 6905424 -0.3576 0.002937 P2ry12 purinergic receptor P2Y, G-protein coupled NM_027571 12 (P2ry12), mRNA. 6823100 -0.3588 0.008268 Usp54 ubiquitin specific peptidase 54 (Usp54), NM_030180 mRNA. 6826916 -0.35898 0.003313 Mzt1 mitotic spindle organizing protein 1 (Mzt1), NM_175245 mRNA. 6900659 -0.35929 0.003443 Extl2 exostoses (multiple)-like 2 (Extl2), NM_001163514 transcript variant 2, mRNA. 6913128 -0.35972 0.009044 Grhpr glyoxylate reductase/hydroxypyruvate NM_080289 reductase (Grhpr), mRNA. 6933818 -0.36175 0.001199 Hrk harakiri, BCL2 interacting protein (contains NM_007545 only BH3 domain) (Hrk), mRNA.

6855176 -0.36341 0.005508 Rpp21 ribonuclease P 21 subunit (human) NM_026308 (Rpp21), mRNA. 6951401 -0.36441 0.003878 Pon3 paraoxonase 3 (Pon3), mRNA. NM_173006 6898897 -0.36473 0.004851 Pet112l PET112-like (yeast) (Pet112l), nuclear NM_144896 gene encoding mitochondrial protein, mRNA. 6825691 -0.36489 0.000364 Piwil2 piwi-like homolog 2 (Drosophila) (Piwil2), NM_021308 mRNA. 6959161 -0.36505 0.009999 Rps19 ribosomal protein S19 (Rps19), mRNA. NM_023133 6952872 -0.36509 0.000483 Zc3hav1l zinc finger CCCH-type, antiviral 1-like NM_172467 (Zc3hav1l), mRNA. 6951247 -0.36613 0.006343 3010003L21Ri cDNA clone IMAGE:6334265. BC106181 k 6878548 -0.36635 0.009218 Dusp19 dual specificity phosphatase 19 (Dusp19), NM_024438 mRNA. 6804024 -0.36649 0.000101 Wdr60 WD repeat domain 60 (Wdr60), mRNA. NM_146039 6972462 -0.36785 0.008871 Cttn cortactin (Cttn), mRNA. NM_007803 6901732 -0.36816 0.00114 Rg9mtd2 RNA (guanine-9-) methyltransferase NM_175389 domain containing 2 (Rg9mtd2), mRNA. 6978890 -0.36828 0.003621 Prmt7 protein arginine N-methyltransferase 7 NM_145404 (Prmt7), mRNA. 6763853 -0.37161 0.00064 Pogk pogo transposable element with KRAB NM_175170 domain (Pogk), transcript variant 1, mRNA.

6924382 -0.3734 0.000122 Gpx7 glutathione peroxidase 7 (Gpx7), mRNA. NM_024198 6792813 -0.37381 0.002001 Dcxr dicarbonyl L-xylulose reductase (Dcxr), NM_026428 mRNA. 6778476 -0.37444 0.000763 Ankrd36 ankyrin repeat domain 36 (Ankrd36), NM_023816 mRNA. 6785742 -0.37463 0.001383 Mrps24 mitochondrial ribosomal protein S24 NM_026080 (Mrps24), nuclear gene encoding mitochondrial protein, mRNA. 6915844 -0.37512 0.00734 Dnajc6 DnaJ (Hsp40) homolog, subfamily C, NM_001164585 member 6 (Dnajc6), transcript variant 3, mRNA. 6934221 -0.37781 0.004368 Bcl7a B-cell CLL/lymphoma 7A (Bcl7a), mRNA. NM_029850

6961182 -0.37818 0.002383 Tarsl2 threonyl-tRNA synthetase-like 2 (Tarsl2), NM_172310 mRNA. 6890986 -0.37946 3.03E-05 Spef1 sperm flagellar 1 (Spef1), mRNA. NM_027641 6978386 -0.37949 0.006464 Gins3 GINS complex subunit 3 (Psf3 homolog) NM_030198 (Gins3), mRNA. 6791528 -0.38074 0.00559 Dusp3 dual specificity phosphatase 3 (vaccinia NM_028207 virus phosphatase VH1-related) (Dusp3), mRNA. 6973718 -0.38075 0.003234 Evi5l ecotropic viral integration site 5 like (Evi5l), NM_001039578 mRNA. 6983243 -0.381 0.009438 Haus8 4HAUS augmin-like complex, subunit 8 NM_001163042 (Haus8), transcript variant 1, mRNA. 6825679 -0.38245 0.007248 9930012K11Ri RIKEN cDNA 9930012K11 gene NM_001004155 k (9930012K11Rik), transcript variant 1, mRNA. 6784245 -0.38253 0.006206 Tubg2 tubulin, gamma 2 (Tubg2), mRNA. NM_134028 6836999 -0.38296 0.00344 Ift27 intraflagellar transport 27 homolog NM_025931 (Chlamydomonas) (Ift27), mRNA. 6952657 -0.38319 0.000353 3110062M04Ri RIKEN cDNA 3110062M04 gene NM_199145 k (3110062M04Rik), transcript variant 1, mRNA. 5241981 -0.38436 0.003103 --- AFFX-r2-Bs-thr-3_s_st, polya_spike --- 6856204 -0.38441 0.000161 Sema6b sema domain, transmembrane domain NM_013662 (TM), and cytoplasmic domain, (semaphorin) 6B (Sema6b), transcript variant 1, mRNA. 6789693 -0.38443 0.000184 Sgsm2 small G protein signaling modulator 2 NM_197943 (Sgsm2), mRNA. 6964635 -0.38473 0.001634 Lhpp phospholysine phosphohistidine inorganic NM_029609 pyrophosphate phosphatase (Lhpp), mRNA. 6759779 -0.38514 0.004253 Atg9a autophagy-related 9A (yeast) (Atg9a), NM_001003917 mRNA. 6775301 -0.3854 0.005666 C2cd4c C2 calcium-dependent domain containing NM_198614 4C (C2cd4c), transcript variant 1, mRNA.

6966292 -0.38585 0.001898 Arhgap33 Rho GTPase activating protein 33 NM_178252 (Arhgap33), mRNA. 6775185 -0.38662 0.000773 Col6a1 collagen, type VI, alpha 1 (Col6a1), mRNA. NM_009933 6787020 -0.38697 0.006215 Chac2 ChaC, cation transport regulator homolog 2 NM_026527 (E. coli) (Chac2), mRNA. 6849525 -0.38701 0.005235 Anks1 ankyrin repeat and SAM domain containing NM_181413 1 (Anks1), mRNA. 6775182 -0.3883 0.001364 Col6a2 collagen, type VI, alpha 2 (Col6a2), mRNA. NM_146007

6995722 -0.389 0.006268 Rab39 RAB39, member RAS oncogene family NM_175562 (Rab39), mRNA. 6983893 -0.38943 0.008621 Rnaseh2a ribonuclease H2, large subunit NM_027187 (Rnaseh2a), mRNA. 6978359 -0.38977 0.001194 Katnb1 katanin p80 (WD40-containing) subunit B 1 NM_028805 (Katnb1), mRNA. 6885749 -0.39002 0.001468 D2Wsu81e DNA segment, Chr 2, Wayne State NM_172660 University 81, expressed (D2Wsu81e), mRNA. 6972204 -0.39099 0.005803 Slc25a22 solute carrier family 25 (mitochondrial NM_026646 carrier, glutamate), member 22 (Slc25a22), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.

6789365 -0.39222 0.001735 Eif5a eukaryotic translation initiation factor 5A NM_001166590 (Eif5a), transcript variant 2, mRNA. 6845912 -0.394 0.005563 Gramd1c GRAM domain containing 1C (Gramd1c), NM_153528 transcript variant 1, mRNA. 6870027 -0.39428 0.009563 Nolc1 nucleolar and coiled-body phosphoprotein NM_053086 1 (Nolc1), transcript variant 1, mRNA.

6790549 -0.39442 0.001548 Rad51c RAD51 homolog c (S. cerevisiae) NM_053269 (Rad51c), mRNA. 6835005 -0.39442 0.000795 Pabpc1 poly(A) binding protein, cytoplasmic 1 NM_008774 (Pabpc1), mRNA. 6917650 -0.39471 4.34E-05 Pafah2 platelet-activating factor acetylhydrolase 2 NM_133880 (Pafah2), mRNA. 6992328 -0.39476 0.00722 Nicn1 nicolin 1 (Nicn1), mRNA. NM_025449 6785446 -0.3955 0.001516 Slc25a10 solute carrier family 25 (mitochondrial NM_013770 carrier, dicarboxylate transporter), member 10 (Slc25a10), nuclear gene encoding mitochondrial protein, mRNA. 6788838 -0.39559 0.001007 Mapk7 mitogen-activated protein kinase 7 NM_011841 (Mapk7), mRNA. 6959007 -0.39589 0.000474 Ppp1r13l protein phosphatase 1, regulatory NM_001010836 (inhibitor) subunit 13 like (Ppp1r13l), mRNA. 6993498 -0.39771 0.007797 4931406C07Ri RIKEN cDNA 4931406C07 gene NM_133732 k (4931406C07Rik), mRNA. 6888029 -0.39822 0.003961 Cwc22 CWC22 spliceosome-associated protein NM_030560 homolog (S. cerevisiae) (Cwc22), mRNA.

6775171 -0.39851 0.000502 Prmt2 protein arginine N-methyltransferase 2 NM_133182 (Prmt2), transcript variant 1, mRNA. 6850661 -0.39908 0.008965 Mrpl14 mitochondrial ribosomal protein L14 NM_026732 (Mrpl14), nuclear gene encoding mitochondrial protein, mRNA. 6857885 -0.39947 0.006697 Srbd1 S1 RNA binding domain 1 (Srbd1), mRNA. NM_030133

6989945 -0.39977 0.001365 Pif1 PIF1 5'-to-3' DNA helicase homolog (S. NM_172453 cerevisiae) (Pif1), mRNA. 6907935 -0.40059 0.006124 Atp5f1 ATP synthase, H+ transporting, NM_009725 mitochondrial F0 complex, subunit B1 (Atp5f1), nuclear gene encoding mitochondrial protein, mRNA. 7020206 -0.40074 3.36E-05 Ribc1 RIB43A domain with coiled-coils 1 (Ribc1), NM_025660 mRNA. 6791443 -0.40075 1.75E-05 Ghdc GH3 domain containing (Ghdc), mRNA. NM_031871 6795936 -0.40228 0.000727 Daam1 dishevelled associated activator of NM_026102 morphogenesis 1 (Daam1), transcript variant 1, mRNA. 6895537 -0.40253 0.00454 Fam164a family with sequence similarity 164, NM_173181 member A (Fam164a), mRNA. 6917794 -0.40326 0.000351 Gale galactose-4-epimerase, UDP (Gale), NM_178389 mRNA. 6892964 -0.4036 5.55E-06 Pltp phospholipid transfer protein (Pltp), mRNA. NM_011125

6964286 -0.40512 0.006823 Zfp553 zinc finger protein 553 (Zfp553), mRNA. NM_146201 6862462 -0.40597 0.001984 Pqlc1 PQ loop repeat containing 1 (Pqlc1), NM_001164420 transcript variant 2, mRNA. 6768114 -0.40625 0.000321 Ankrd57 ankyrin repeat domain 57 (Ankrd57), NM_172939 mRNA. 6823059 -0.40672 0.002157 Mrps16 mitochondrial ribosomal protein S16 NM_025440 (Mrps16), nuclear gene encoding mitochondrial protein, mRNA. 6970839 -0.40692 0.000362 Coq7 demethyl-Q 7 (Coq7), mRNA. NM_009940 6958845 -0.40696 0.002022 Bbc3 BCL2 binding component 3 (Bbc3), mRNA. NM_133234

6854463 -0.40731 0.002735 Nme4 non-metastatic cells 4, protein expressed NM_019731 in (Nme4), nuclear gene encoding mitochondrial protein, mRNA. 6935904 -0.40758 0.007311 Gatad1 GATA zinc finger domain containing 1 NM_026033 (Gatad1), mRNA. 6796339 -0.40769 0.000603 Rdh12 retinol dehydrogenase 12 (Rdh12), mRNA. NM_030017

6795448 -0.40798 0.007514 Sip1 survival of motor neuron protein interacting NM_025656 protein 1 (Sip1), mRNA. 6929735 -0.40805 0.001077 Yes1 Yamaguchi sarcoma viral (v-yes) NM_009535 oncogene homolog 1 (Yes1), mRNA. 6957316 -0.40906 0.003985 Tspan9 tetraspanin 9 (Tspan9), mRNA. NM_175414 6856215 -0.40974 0.000698 Ticam1 toll-like receptor adaptor molecule 1 NM_174989 (Ticam1), mRNA. 6881820 -0.40986 0.000106 8430406I07Rik RIKEN cDNA 8430406I07 gene, mRNA BC063088 (cDNA clone MGC:69979 IMAGE:6329248), complete cds. 6769147 -0.41005 4.25E-05 Palm paralemmin (Palm), transcript variant 1, NM_023128 mRNA. 6933602 -0.4102 0.000186 Mvk mevalonate kinase (Mvk), mRNA. NM_023556 6782443 -0.41031 0.000492 Tlcd2 TLC domain containing 2 (Tlcd2), mRNA. NM_027249

6933252 -0.41151 4.68E-05 Ephx4 epoxide hydrolase 4 (Ephx4), mRNA. NM_001001804 6936723 -0.41268 0.005932 Atg9b ATG9 autophagy related 9 homolog B (S. NM_001002897 cerevisiae) (Atg9b), mRNA. 6950373 -0.41283 0.001329 Loh12cr1 loss of heterozygosity, 12, chromosomal NM_026371 region 1 homolog (human) (Loh12cr1), transcript variant 2, mRNA. 6906858 -0.41614 0.007368 Ubap2l ubiquitin associated protein 2-like (Ubap2l), NM_028475 transcript variant 1, mRNA. 6959180 -0.41887 0.007085 Zfp574 zinc finger protein 574 (Zfp574), transcript NM_175477 variant 1, mRNA. 6933390 -0.41937 0.00328 Plcxd1 phosphatidylinositol-specific phospholipase NM_207279 C, X domain containing 1 (Plcxd1), transcript variant 1, mRNA. 6885489 -0.42111 0.006191 Agpat2 1-acylglycerol-3-phosphate O- NM_026212 acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2), mRNA. 6878710 -0.42159 0.00969 Timm10 translocase of inner mitochondrial NM_013899 membrane 10 homolog (yeast) (Timm10), nuclear gene encoding mitochondrial protein, mRNA. 6949283 -0.42226 6.12E-06 8-Mar membrane-associated ring finger (C3HC4) NM_027920 8 (March8), mRNA. 6885901 -0.42248 0.001146 Fpgs folylpolyglutamyl synthetase (Fpgs), NM_010236 nuclear gene encoding mitochondrial protein, mRNA. 6890382 -0.4231 0.001344 Ppip5k1 diphosphoinositol pentakisphosphate NM_178795 kinase 1 (Ppip5k1), mRNA. 6928464 -0.42366 0.003263 Pex1 peroxisomal biogenesis factor 1 (Pex1), NM_027777 mRNA. 7009796 -0.42575 0.00059 Slc35a2 solute carrier family 35 (UDP-galactose NM_001083937 transporter), member A2 (Slc35a2), transcript variant 2, mRNA. 6824840 -0.42577 0.002609 Rabggta Rab geranylgeranyl transferase, a subunit NM_019519 (Rabggta), mRNA. 6831654 -0.42578 0.007288 Brp16 brain protein 16 (Brp16), mRNA. NM_021555 6918049 -0.42692 0.002001 Aldh4a1 aldehyde dehydrogenase 4 family, member NM_175438 A1 (Aldh4a1), nuclear gene encoding mitochondrial protein, mRNA. 6966921 -0.42757 0.000334 Cpt1c carnitine palmitoyltransferase 1c (Cpt1c), NM_153679 mRNA. 6912113 -0.42819 0.003738 Fbxl4 F-box and leucine-rich repeat protein 4 NM_172988 (Fbxl4), mRNA. 6985373 -0.43038 0.002754 Wdr59 WD repeat domain 59 (Wdr59), transcript NM_001170743 variant 1, mRNA. 6792819 -0.43089 0.000396 Rfng RFNG O-fucosylpeptide 3-beta-N- NM_009053 acetylglucosaminyltransferase (Rfng), mRNA. 6854868 -0.43137 0.006119 Brd4 bromodomain containing 4 (Brd4), NM_020508 transcript variant 1, mRNA. 6769245 -0.43163 0.004913 Sf3a2 splicing factor 3a, subunit 2 (Sf3a2), NM_013651 mRNA. 6892308 -0.43165 0.008436 Pxmp4 peroxisomal membrane protein 4 (Pxmp4), NM_021534 mRNA. 6964424 -0.43228 0.002639 Bag3 BCL2-associated athanogene 3 (Bag3), NM_013863 mRNA. 6941048 -0.43287 0.00442 Pus1 pseudouridine synthase 1 (Pus1), NM_001025561 transcript variant 1, mRNA. 6975904 -0.43398 0.001508 Mlf1ip myeloid leukemia factor 1 interacting NM_027973 protein (Mlf1ip), mRNA. 6899053 -0.43469 0.000132 Iqgap3 IQ motif containing GTPase activating NM_001033484 protein 3 (Iqgap3), mRNA. 6806991 -0.43548 0.002495 Fbxw17 F-box and WD-40 domain protein 17 NM_175401 (Fbxw17), mRNA. 6965940 -0.43573 0.008061 Pafah1b3 platelet-activating factor acetylhydrolase, NM_008776 isoform 1b, subunit 3 (Pafah1b3), mRNA.

6969832 -0.43583 0.004345 Relt RELT tumor necrosis factor receptor (Relt), NM_177073 mRNA. 6962065 -0.43764 0.008373 Whamm WAS protein homolog associated with NM_001004185 actin, golgi membranes and microtubules (Whamm), mRNA. 6854444 -0.43782 0.006207 Stub1 STIP1 homology and U-Box containing NM_019719 protein 1 (Stub1), mRNA. 6880476 -0.43788 0.00452 Chst14 carbohydrate (N-acetylgalactosamine 4-0) NM_028117 sulfotransferase 14 (Chst14), mRNA. 6951088 -0.43792 0.002617 Fgfr1op2 FGFR1 oncogene partner 2 (Fgfr1op2), NM_026218 mRNA. 6983840 -0.4386 0.005164 Ccdc130 coiled-coil domain containing 130 NM_026350 (Ccdc130), mRNA. 6965631 -0.43881 0.000667 Grlf1 glucocorticoid receptor DNA binding factor NM_172739 1 (Grlf1), mRNA. 6983210 -0.43989 0.004634 Ssbp4 single stranded DNA binding protein 4 NM_133772 (Ssbp4), mRNA. 6995071 -0.44012 0.005176 C2cd2l C2 calcium-dependent domain containing NM_027909 2-like (C2cd2l), mRNA. 6917046 -0.44028 0.003706 Mtf1 metal response element binding NM_008636 transcription factor 1 (Mtf1), mRNA. 6812637 -0.44061 0.000168 Gcm2 glial cells missing homolog 2 (Drosophila) NM_008104 (Gcm2), mRNA. 6870931 -0.44114 0.000787 Lrp5 low density lipoprotein receptor-related NM_008513 protein 5 (Lrp5), mRNA. 6960621 -0.44149 0.00984 Htatip2 HIV-1 tat interactive protein 2, homolog NM_001146049 (human) (Htatip2), transcript variant 2, mRNA. 6782668 -0.44216 0.003665 BC017647 cDNA sequence BC017647 (BC017647), NM_145430 mRNA. 6800723 -0.44284 0.005617 Heatr5a HEAT repeat containing 5A (Heatr5a), NM_177171 mRNA. 6977052 -0.44301 0.002993 Mtap1s microtubule-associated protein 1S NM_173013 (Mtap1s), mRNA. 6989354 -0.44335 0.006197 Imp3 IMP3, U3 small nucleolar NM_133976 ribonucleoprotein, homolog (yeast) (Imp3), mRNA. 6956740 -0.44361 2.92E-05 Mbd4 methyl-CpG binding domain protein 4 NM_010774 (Mbd4), mRNA. 6885923 -0.44379 0.001673 Slc2a8 solute carrier family 2, (facilitated glucose NM_019488 transporter), member 8 (Slc2a8), mRNA.

6819269 -0.44417 0.007305 Gmpr2 guanosine monophosphate reductase 2 NM_177992 (Gmpr2), mRNA. 6929648 -0.4445 0.004081 Tmem214 transmembrane protein 214 (Tmem214), NM_144525 mRNA. 6941866 -0.44493 0.006891 Pitpnm2 phosphatidylinositol transfer protein, NM_011256 membrane-associated 2 (Pitpnm2), mRNA.

6932883 -0.44529 2.14E-05 Agpat9 1-acylglycerol-3-phosphate O- NM_172715 acyltransferase 9 (Agpat9), transcript variant 1, mRNA. 6926934 -0.44642 0.000602 Apitd1 apoptosis-inducing, TAF9-like domain 1 NM_027263 (Apitd1), mRNA. 6972200 -0.44652 0.002197 Deaf1 deformed epidermal autoregulatory factor 1 NM_016874 (Drosophila) (Deaf1), transcript variant 1, mRNA. 6831164 -0.44757 0.000521 Wisp1 WNT1 inducible signaling pathway protein NM_018865 1 (Wisp1), mRNA. 6941224 -0.44769 0.002797 1500011B03Ri RIKEN cDNA 1500011B03 gene NR_027817 k (1500011B03Rik), transcript variant 1, non- coding RNA. 6875376 -0.44831 0.006295 Bmi1 Bmi1 polycomb ring finger oncogene NM_007552 (Bmi1), mRNA. 6846193 -0.45088 0.003644 Gm4827 Putative uncharacterized protein ENSMUST00000074055 gene:ENSMUSG00000063398 6854430 -0.4533 0.000437 Chtf18 CTF18, chromosome transmission fidelity NM_145409 factor 18 homolog (S. cerevisiae) (Chtf18), mRNA. 6803527 -0.45337 0.00739 Setd3 SET domain containing 3 (Setd3), mRNA. NM_028262

6913975 -0.45367 0.000707 Bspry B-box and SPRY domain containing NM_138653 (Bspry), mRNA. 6910122 -0.45419 0.009274 Sh3glb1 SH3-domain GRB2-like B1 (endophilin) NM_019464 (Sh3glb1), mRNA. 6977787 -0.45425 3.13E-05 Fbxw9 F-box and WD-40 domain protein 9 NM_026791 (Fbxw9), mRNA. 6919596 -0.45435 0.001422 Asph aspartate-beta-hydroxylase (Asph), NM_023066 transcript variant 1, mRNA. 6837022 -0.45626 0.002808 C1qtnf6 C1q and tumor necrosis factor related NM_028331 protein 6 (C1qtnf6), mRNA. 6796193 -0.45647 0.000296 Plekhg3 pleckstrin homology domain containing, NM_153804 family G (with RhoGef domain) member 3 (Plekhg3), mRNA. 6901962 -0.45656 0.000117 Ccbl2 cysteine conjugate-beta lyase 2 (Ccbl2), NM_173763 mRNA. 6998584 -0.45692 0.001331 Abhd14a abhydrolase domain containing 14A NM_001110271 (Abhd14a), transcript variant 1, mRNA. 6925350 -0.45697 0.001253 Mtap7d1 microtubule-associated protein 7 domain NM_144941 containing 1 (Mtap7d1), transcript variant 1, mRNA. 6933665 -0.45701 0.005207 Triap1 TP53 regulated inhibitor of apoptosis 1 NM_026933 (Triap1), mRNA. 6814376 -0.4572 0.000841 Cep72 centrosomal protein 72 (Cep72), mRNA. NM_028959 6934660 -0.45781 0.005884 Rabgef1 RAB guanine nucleotide exchange factor NM_019983 (GEF) 1 (Rabgef1), mRNA. 6977091 -0.45899 0.002116 Fam129c family with sequence similarity 129, NM_001166213 member C (Fam129c), mRNA. 6836782 -0.45927 0.001284 Pycrl pyrroline-5-carboxylate reductase-like NM_025412 (Pycrl), mRNA. 7014637 -0.45939 0.000431 Klf8 Kruppel-like factor 8 (Klf8), mRNA. NM_173780 6781607 -0.45946 0.007336 Fam18b family with sequence similarity 18, member BC115504 B, mRNA (cDNA clone MGC:144327 IMAGE:40101013), complete cds.

6983199 -0.45977 0.001434 2810422J05Ri RIKEN cDNA 2810422J05 gene NM_029366 k (2810422J05Rik), mRNA. 6892376 -0.46021 0.000111 Gss glutathione synthetase (Gss), mRNA. NM_008180 6952436 -0.46085 0.007457 Tsga14 testis specific gene A14 (Tsga14), mRNA. NM_031998

6820088 -0.46092 0.000997 Nudt18 nudix (nucleoside diphosphate linked NM_153136 moiety X)-type motif 18 (Nudt18), mRNA.

6785609 -0.46145 0.003041 Smtn smoothelin (Smtn), transcript variant 1, NM_001159284 mRNA. 6748535 -0.46298 4.87E-05 Ptpn18 protein tyrosine phosphatase, non-receptor NM_011206 type 18 (Ptpn18), mRNA. 6911857 -0.46324 0.009756 Tmem55a transmembrane protein 55A (Tmem55a), NM_028264 mRNA. 6780797 -0.4633 0.008171 Hnrnph1 heterogeneous nuclear ribonucleoprotein NM_021510 H1 (Hnrnph1), mRNA. 6854273 -0.46401 0.000549 Flywch1 FLYWCH-type zinc finger 1 (Flywch1), NM_153791 mRNA. 6955010 -0.46466 0.009007 Wbp1 WW domain binding protein 1 (Wbp1), NM_016757 transcript variant 1, mRNA. 6843657 -0.46517 0.00258 Nmral1 NmrA-like family domain containing 1 NM_026393 (Nmral1), mRNA. 6869216 -0.46544 0.005057 Papss2 3'-phosphoadenosine 5'-phosphosulfate NM_011864 synthase 2 (Papss2), mRNA. 6999114 -0.46579 0.000618 Crtap cartilage associated protein (Crtap), NM_019922 mRNA. 6864585 -0.46612 0.000479 Sil1 endoplasmic reticulum chaperone SIL1 NM_030749 homolog (S. cerevisiae) (Sil1), mRNA. 6817393 -0.46638 0.001643 Vcl vinculin (Vcl), mRNA. NM_009502 6773582 -0.46666 0.000127 Sobp sine oculis-binding protein homolog NM_175407 (Drosophila) (Sobp), mRNA. 6996370 -0.46712 0.000429 Zfp609 zinc finger protein 609 (Zfp609), mRNA. NM_172536 6954638 -0.46879 0.006109 Tgoln1 trans-golgi network protein (Tgoln1), NM_009443 mRNA. 6789419 -0.46916 0.008051 Pelp1 proline, glutamic acid and leucine rich NM_029231 protein 1 (Pelp1), mRNA. 6997040 -0.46955 0.004272 Lrrc1 leucine rich repeat containing 1 (Lrrc1), NM_001146048 transcript variant 1, mRNA. 6965143 -0.46969 0.00279 Athl1 ATH1, acid trehalase-like 1 (yeast) (Athl1), NM_145387 mRNA. 6780782 -0.46983 0.000736 Mgat4b mannoside acetylglucosaminyltransferase NM_145926 4, isoenzyme B (Mgat4b), mRNA.

7017578 -0.47038 0.004485 Haus7 HAUS augmin-like complex, subunit 7 NM_028633 (Haus7), transcript variant 1, mRNA. 6880423 -0.47115 0.00703 Eif2ak4 eukaryotic translation initiation factor 2 NM_013719 alpha kinase 4 (Eif2ak4), transcript variant 1, mRNA. 6935018 -0.47131 0.000205 Myl10 myosin, light chain 10, regulatory (Myl10), NM_021611 transcript variant 1, mRNA. 6950485 -0.47198 0.004734 Atf7ip activating transcription factor 7 interacting NM_019426 protein (Atf7ip), mRNA. 6990543 -0.47223 0.003382 Leo1 Leo1, Paf1/RNA polymerase II complex NM_001039522 component, homolog (S. cerevisiae) (Leo1), mRNA. 6892230 -0.47305 0.007351 8430427H17Ri RIKEN cDNA 8430427H17 gene NM_001134300 k (8430427H17Rik), transcript variant 2, mRNA. 6867626 -0.47307 0.003191 Nudt8 nudix (nucleoside diphosphate linked NM_025529 moiety X)-type motif 8 (Nudt8), mRNA. 6925910 -0.47367 0.005834 Nudc nuclear distribution gene C homolog NM_010948 (Aspergillus) (Nudc), mRNA. 6761915 -0.47368 0.003809 Nckap5 NCK-associated protein 5 (Nckap5), NM_172484 transcript variant 2, mRNA. 6789805 -0.47379 0.005027 Gemin4 gem (nuclear organelle) associated protein NM_177367 4 (Gemin4), mRNA. 6919050 -0.47382 0.000849 A430005L14Ri RIKEN cDNA A430005L14 gene NM_175287 k (A430005L14Rik), transcript variant 1, mRNA. 6962941 -0.47399 0.004707 Chchd8 coiled-coil-helix-coiled-coil-helix domain NM_183270 containing 8 (Chchd8), mRNA. 6970744 -0.4753 8.52E-05 Plekha7 pleckstrin homology domain containing, NM_172743 family A member 7 (Plekha7), mRNA. 6769165 -0.47548 0.000249 Arid3a AT rich interactive domain 3A (BRIGHT- NM_007880 like) (Arid3a), mRNA. 6844531 -0.47579 0.008806 Ehhadh enoyl-Coenzyme A, hydratase/3- NM_023737 hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA. 6899315 -0.47589 0.008291 Tpm3 tropomyosin 3, gamma (Tpm3), mRNA. NM_022314 6774704 -0.47604 0.002479 Zfp365 zinc finger protein 365 (Zfp365), mRNA. NM_178679 6785684 -0.47611 0.001567 Nefh neurofilament, heavy polypeptide (Nefh), NM_010904 mRNA. 6983280 -0.47613 5.65E-05 B3gnt3 UDP-GlcNAc:betaGal beta-1,3-N- NM_028189 acetylglucosaminyltransferase 3 (B3gnt3), mRNA. 6965076 -0.47667 0.008703 Zfp511 zinc finger protein 511 (Zfp511), mRNA. NM_027201 6986088 -0.4768 0.000849 Exoc8 exocyst complex component 8 (Exoc8), NM_198103 mRNA. 6883186 -0.47749 0.000417 Eya2 eyes absent 2 homolog (Drosophila) NM_010165 (Eya2), mRNA. 6931835 -0.47769 0.000476 Paics phosphoribosylaminoimidazole NM_025939 carboxylase, phosphoribosylaminoribosylaminoimidazol e, succinocarboxamide synthetase (Paics), mRNA. 6933784 -0.47837 0.006219 Taok3 TAO kinase 3 (Taok3), mRNA. NM_001081308 6952168 -0.47924 0.009752 Ndufa5 NADH dehydrogenase (ubiquinone) 1 NM_026614 alpha subcomplex, 5 (Ndufa5), nuclear gene encoding mitochondrial protein, mRNA. 6929298 -0.47935 0.000655 Abcb8 ATP-binding cassette, sub-family B NM_029020 (MDR/TAP), member 8 (Abcb8), nuclear gene encoding mitochondrial protein, mRNA. 6974830 -0.4794 0.007365 Erlin2 ER lipid raft associated 2 (Erlin2), mRNA. NM_153592

6819214 -0.47951 0.000463 Thtpa thiamine triphosphatase (Thtpa), mRNA. NM_153083 6802557 -0.47985 0.006665 Snw1 SNW domain containing 1 (Snw1), mRNA. NM_025507

6961232 -0.48084 0.008044 Lins lines homolog (Drosophila) (Lins), NM_152815 transcript variant 1, mRNA. 6958922 -0.48094 0.001325 Ptgir prostaglandin I receptor (IP) (Ptgir), mRNA. NM_008967

6854971 -0.48184 7.25E-06 Angptl4 angiopoietin-like 4 (Angptl4), mRNA. NM_020581 6813839 -0.482 0.007872 Fancc Fanconi anemia, complementation group C NM_007985 (Fancc), transcript variant 1, mRNA.

6922241 -0.48302 0.008841 Alad aminolevulinate, delta-, dehydratase NM_008525 (Alad), mRNA. 6965848 -0.48344 0.005484 Zfp111 zinc finger protein 111 (Zfp111), mRNA. NM_019940 6954425 -0.48368 0.003029 Tacstd2 tumor-associated calcium signal NM_020047 transducer 2 (Tacstd2), mRNA. 6925880 -0.48467 0.005696 Tmem222 transmembrane protein 222 (Tmem222), NM_025667 mRNA. 6936760 -0.48475 0.001823 Prkag2 protein kinase, AMP-activated, gamma 2 NM_145401 non-catalytic subunit (Prkag2), transcript variant 1, mRNA. 7017621 -0.4849 7.95E-05 Dnase1l1 deoxyribonuclease 1-like 1 (Dnase1l1), NM_027109 transcript variant 1, mRNA. 6761669 -0.485 0.00667 Ralb v-ral simian leukemia viral oncogene NM_022327 homolog B (ras related) (Ralb), mRNA. 6785441 -0.48541 0.0041 Mrpl12 mitochondrial ribosomal protein L12 NM_027204 (Mrpl12), nuclear gene encoding mitochondrial protein, mRNA. 6884199 -0.4855 0.004833 Slc17a9 solute carrier family 17, member 9 NM_183161 (Slc17a9), mRNA. 6851764 -0.48617 0.00636 Ddx11 DEAD/H (Asp-Glu-Ala-Asp/His) box NM_001003919 polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (Ddx11), mRNA. 6905200 -0.48689 0.000376 Rfxap regulatory factor X-associated protein NM_133231 (Rfxap), mRNA. 6966986 -0.48712 0.00076 Dhdh dihydrodiol dehydrogenase (dimeric) NM_027903 (Dhdh), mRNA. 6942563 -0.48789 0.000687 Agfg2 ArfGAP with FG repeats 2 (Agfg2), NM_178162 transcript variant 2, mRNA. 6886009 -0.48824 0.005312 Rabepk Rab9 effector protein with kelch motifs NM_145522 (Rabepk), mRNA. 6917817 -0.48834 0.003128 Zfp46 zinc finger protein 46 (Zfp46), mRNA. NM_009557 6846463 -0.48854 0.005305 2610528E23Ri RIKEN cDNA 2610528E23 gene NM_025599 k (2610528E23Rik), mRNA. 6964798 -0.48893 0.006332 Ptpre protein tyrosine phosphatase, receptor NM_011212 type, E (Ptpre), mRNA. 6959198 -0.48893 0.008269 Cic capicua homolog (Drosophila) (Cic), NM_027882 transcript variant 1, mRNA. 6798640 -0.48939 0.005109 Ubxn2a UBX domain protein 2A (Ubxn2a), mRNA. NM_145441

6935128 -0.48942 3.69E-05 Stag3 stromal antigen 3 (Stag3), mRNA. NM_016964 6983888 -0.48951 0.003106 Gcdh glutaryl-Coenzyme A dehydrogenase NM_008097 (Gcdh), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6966293 -0.48983 0.003904 BC053749 cDNA sequence BC053749, mRNA (cDNA BC053749 clone MGC:59495 IMAGE:6331972), complete cds. 7011014 -0.49021 0.005359 Ocrl oculocerebrorenal syndrome of Lowe NM_177215 (Ocrl), mRNA. 6844310 -0.49072 0.008372 Slc25a1 solute carrier family 25 (mitochondrial NM_153150 carrier, citrate transporter), member 1 (Slc25a1), nuclear gene encoding mitochondrial protein, mRNA. 6929301 -0.49296 0.004562 Slc4a2 solute carrier family 4 (anion exchanger), NM_009207 member 2 (Slc4a2), mRNA. 6784280 -0.49337 0.002137 Tmem106a transmembrane protein 106A NM_144830 (Tmem106a), mRNA. 6888299 -0.49456 0.001361 Tfpi tissue factor pathway inhibitor (Tfpi), NM_011576 transcript variant 1, mRNA. 6773940 -0.49467 0.009113 Gopc golgi associated PDZ and coiled-coil motif NM_053187 containing (Gopc), mRNA. 6877441 -0.49496 0.009908 Tanc1 tetratricopeptide repeat, ankyrin repeat and NM_198294 coiled-coil containing 1 (Tanc1), mRNA.

6845800 -0.49516 0.004881 Gap43 growth associated protein 43 (Gap43), NM_008083 mRNA. 6902764 -0.49524 0.00328 Ptger3 prostaglandin E receptor 3 (subtype EP3) NM_011196 (Ptger3), mRNA. 6873235 -0.49579 0.007471 Cox15 COX15 homolog, cytochrome c oxidase NM_144874 assembly protein (yeast) (Cox15), nuclear gene encoding mitochondrial protein, mRNA. 6875039 -0.4961 0.000381 Il15ra interleukin 15 receptor, alpha chain NM_008358 (Il15ra), transcript variant 1, mRNA. 6921068 -0.49651 0.005293 Dctn3 dynactin 3 (Dctn3), transcript variant 1, NM_016890 mRNA. 6849433 -0.49651 0.002084 Mrpl28 mitochondrial ribosomal protein L28 NM_024227 (Mrpl28), nuclear gene encoding mitochondrial protein, mRNA. 6824799 -0.49652 0.00345 Ap1g2 adaptor protein complex AP-1, gamma 2 NM_007455 subunit (Ap1g2), mRNA. 6949962 -0.49715 0.008227 D6Wsu163e DNA segment, Chr 6, Wayne State BC016429 University 163, expressed, mRNA (cDNA clone MGC:25665 IMAGE:4486831), complete cds. 6817951 -0.49776 0.007344 Sfmbt1 Scm-like with four mbt domains 1 NM_001166532 (Sfmbt1), transcript variant 1, mRNA. 6824829 -0.49902 0.007454 Ipo4 importin 4 (Ipo4), mRNA. NM_024267 6797950 -0.50006 0.009299 Yy1 YY1 transcription factor (Yy1), mRNA. NM_009537 6977756 -0.5001 0.006531 Trmt1 TRM1 tRNA methyltransferase 1 homolog NM_198020 (S. cerevisiae) (Trmt1), transcript variant 1, mRNA. 6844542 -0.50063 0.000883 Tmem41a transmembrane protein 41a (Tmem41a), NM_025693 mRNA. 6966895 -0.50068 9.24E-06 Zfp473 zinc finger protein 473 (Zfp473), mRNA. NM_178734 6769262 -0.5007 0.00022 Thop1 thimet oligopeptidase 1 (Thop1), mRNA. NM_022653 6792506 -0.50146 0.007482 Exoc7 exocyst complex component 7 (Exoc7), NM_016857 transcript variant 1, mRNA. 6854874 -0.50186 0.000469 Wiz widely-interspaced zinc finger motifs (Wiz), NR_033525 transcript variant 3, non-coding RNA.

6907351 -0.50259 0.007762 Pde4dip phosphodiesterase 4D interacting protein NM_001039376 (myomegalin) (Pde4dip), transcript variant 1, mRNA. 6782147 -0.50271 0.004968 Kif1c kinesin family member 1C (Kif1c), mRNA. NM_153103

6992178 -0.50385 0.005204 Rrp9 RRP9, small subunit (SSU) processome NM_145620 component, homolog (yeast) (Rrp9), mRNA. 6769614 -0.50386 0.000445 Nup37 nucleoporin 37 (Nup37), transcript variant NM_028334 1, mRNA. 6917789 -0.50427 0.008781 Cnr2 cannabinoid receptor 2 (macrophage) NM_009924 (Cnr2), mRNA. 6941647 -0.50452 0.004142 Oas2 2'-5' oligoadenylate synthetase 2 (Oas2), NM_145227 mRNA. 6976520 -0.50473 0.001038 Sh3rf1 SH3 domain containing ring finger 1 NM_021506 (Sh3rf1), mRNA. 6964352 -0.50475 0.002442 Setd1a SET domain containing 1A (Setd1a), NM_178029 mRNA. 7012614 -0.50524 1.6E-05 Gspt2 G1 to S phase transition 2 (Gspt2), mRNA. NM_008179

6927317 -0.50548 0.00647 Gltpd1 glycolipid transfer protein domain NM_024472 containing 1 (Gltpd1), mRNA. 6892371 -0.50575 0.006178 Ncoa6 nuclear receptor coactivator 6 (Ncoa6), NM_019825 mRNA. 6921173 -0.50651 0.001174 Hint2 histidine triad nucleotide binding protein 2 NM_026871 (Hint2), nuclear gene encoding mitochondrial protein, mRNA. 6936730 -0.50862 0.00128 Tmub1 transmembrane and ubiquitin-like domain NM_022418 containing 1 (Tmub1), mRNA. 6855680 -0.50935 0.00652 Tjap1 tight junction associated protein 1 (Tjap1), NM_028751 mRNA. 6792507 -0.50952 0.000193 Foxj1 forkhead box J1 (Foxj1), mRNA. NM_008240 6836079 -0.50979 0.000561 Fam84b family with sequence similarity 84, member NM_001162926 B (Fam84b), mRNA. 6957150 -0.51 0.002983 Cops7a COP9 (constitutive photomorphogenic) NM_012003 homolog, subunit 7a (Arabidopsis thaliana) (Cops7a), transcript variant 1, mRNA.

6924808 -0.51047 0.008539 Mmachc methylmalonic aciduria cblC type, with NM_025962 homocystinuria (Mmachc), mRNA. 6834413 -0.51065 0.003142 Basp1 brain abundant, membrane attached signal NM_027395 protein 1 (Basp1), mRNA. 6926864 -0.51107 0.007425 Clcn6 chloride channel 6 (Clcn6), mRNA. NM_011929 6771578 -0.51129 0.006659 Tmem194 transmembrane protein 194 (Tmem194), NM_001113211 transcript variant 1, mRNA. 6918892 -0.5118 8.82E-06 Errfi1 ERBB receptor feedback inhibitor 1 NM_133753 (Errfi1), mRNA. 6965087 -0.51194 0.00124 Mtg1 mitochondrial GTPase 1 homolog (S. NM_199301 cerevisiae) (Mtg1), nuclear gene encoding mitochondrial protein, mRNA. 6870102 -0.51202 0.002115 2010012O05Ri RIKEN cDNA 2010012O05 gene, mRNA BC027506 k (cDNA clone MGC:41041 IMAGE:1514880), complete cds. 7016693 -0.51223 0.001361 Zdhhc9 zinc finger, DHHC domain containing 9 NM_172465 (Zdhhc9), mRNA. 6773525 -0.51228 0.005369 2410017P07Ri RIKEN cDNA 2410017P07 gene NM_029132 k (2410017P07Rik), transcript variant 1, mRNA. 6993845 -0.51261 5.9E-05 Rab3d RAB3D, member RAS oncogene family NM_031874 (Rab3d), mRNA. 6885811 -0.51265 0.004579 Fnbp1 formin binding protein 1 (Fnbp1), transcript NM_001177648 variant 3, mRNA. 6871199 -0.51291 0.000321 Arl2 ADP-ribosylation factor-like 2 (Arl2), NM_019722 mRNA. 6926017 -0.51317 0.00011 Extl1 exostoses (multiple)-like 1 (Extl1), mRNA. NM_019578

6915818 -0.51324 0.000168 Raver2 ribonucleoprotein, PTB-binding 2 (Raver2), NM_183024 mRNA. 6873154 -0.51336 0.003442 Rrp12 ribosomal RNA processing 12 homolog (S. NM_199447 cerevisiae) (Rrp12), mRNA. 6918699 -0.51383 0.002498 Mad2l2 MAD2 mitotic arrest deficient-like 2 (yeast) NM_027985 (Mad2l2), mRNA. 6861892 -0.51402 0.004944 Mbd2 methyl-CpG binding domain protein 2 NM_010773 (Mbd2), mRNA. 6921382 -0.51416 0.000661 Tbc1d2 TBC1 domain family, member 2 (Tbc1d2), NM_198664 mRNA. 6840603 -0.51564 0.008587 Rpl35a ribosomal protein L35A (Rpl35a), transcript NM_021338 variant 1, mRNA. 6965614 -0.51567 0.007805 Ccdc9 coiled-coil domain containing 9 (Ccdc9), NM_001136471 transcript variant 1, mRNA. 6966164 -0.5159 0.001212 Mrps12 mitochondrial ribosomal protein S12 NM_011885 (Mrps12), nuclear gene encoding mitochondrial protein, mRNA. 6972149 -0.51636 9.78E-05 BC066028 cDNA sequence BC066028 (BC066028), NM_001001180 mRNA. 6940872 -0.51654 0.006868 Gfi1 growth factor independent 1 (Gfi1), mRNA. NM_010278

6977682 -0.51696 0.002432 Gipc1 GIPC PDZ domain containing family, NM_018771 member 1 (Gipc1), mRNA. 6837787 -0.51708 0.001795 Plxnb2 plexin B2 (Plxnb2), mRNA. NM_001159521 6837189 -0.51841 0.000244 Rps19bp1 ribosomal protein S19 binding protein 1 NM_175109 (Rps19bp1), mRNA. 6965670 -0.51895 0.000706 Hif3a hypoxia inducible factor 3, alpha subunit NM_016868 (Hif3a), transcript variant 2, mRNA. 6971307 -0.51942 0.004633 Tmem219 transmembrane protein 219 (Tmem219), NM_026827 transcript variant 1, mRNA. 6996743 -0.51954 0.007756 Tex9 testis expressed gene 9 (Tex9), mRNA. NM_009359 6881146 -0.51996 0.001906 Stk35 serine/threonine kinase 35 (Stk35), NM_183262 transcript variant 1, mRNA. 6996223 -0.52016 0.002628 Fem1b feminization 1 homolog b (C. elegans) NM_010193 (Fem1b), mRNA. 6906818 -0.52065 0.000105 Trim46 tripartite motif-containing 46 (Trim46), NM_183037 transcript variant 2, mRNA. 6748605 -0.52077 0.004038 Hs6st1 heparan sulfate 6-O-sulfotransferase 1 NM_015818 (Hs6st1), mRNA. 6846647 -0.52103 0.003645 Arl13b ADP-ribosylation factor-like 13B (Arl13b), NM_026577 mRNA. 6996127 -0.52117 2.13E-05 Lrrc49 leucine rich repeat containing 49 (Lrrc49), NM_145616 transcript variant 2, mRNA. 6873167 -0.52223 0.000491 Morn4 MORN repeat containing 4 (Morn4), NM_198108 mRNA. 6831984 -0.52269 0.007371 Tab1 TGF-beta activated kinase 1/MAP3K7 NM_025609 binding protein 1 (Tab1), mRNA. 6871259 -0.52282 0.000544 Esrra estrogen related receptor, alpha (Esrra), NM_007953 mRNA. 6959447 -0.52313 0.004865 Fbxo17 F-box protein 17 (Fbxo17), mRNA. NM_015796 6959461 -0.5243 8.54E-05 Lgals7 lectin, galactose binding, soluble 7 NM_008496 (Lgals7), mRNA. 6759396 -0.52465 0.004218 Idh1 isocitrate dehydrogenase 1 (NADP+), NM_001111320 soluble (Idh1), transcript variant 1, mRNA.

6966925 -0.5247 0.001035 Scaf1 SR-related CTD-associated factor 1 NM_001008422 (Scaf1), mRNA. 6800726 -0.52496 0.000909 6530401N04Ri RIKEN cDNA 6530401N04 gene NM_029545 k (6530401N04Rik), mRNA. 6966231 -0.52537 0.002075 Zfp27 zinc finger protein 27 (Zfp27), transcript NM_001037707 variant 1, mRNA. 6937315 -0.5268 0.008088 Tnip2 TNFAIP3 interacting protein 2 (Tnip2), NM_139064 mRNA. 6942939 -0.52687 0.003955 Aimp2 aminoacyl tRNA synthetase complex- NM_001172146 interacting multifunctional protein 2 (Aimp2), transcript variant 1, mRNA. 6755819 -0.52697 0.005653 Srp9 signal recognition particle 9 (Srp9), mRNA. NM_012058

6803850 -0.52748 0.009222 Ckb creatine kinase, brain (Ckb), mRNA. NM_021273 6976902 -0.52855 0.006528 Ints10 integrator complex subunit 10 (Ints10), NM_027590 mRNA. 6979670 -0.53022 0.00338 Spg7 spastic paraplegia 7 homolog (human) NM_153176 (Spg7), nuclear gene encoding mitochondrial protein, mRNA. 6921020 -0.53024 0.000655 Ubap2 ubiquitin-associated protein 2 (Ubap2), NM_026872 mRNA. 6992864 -0.53037 0.000115 Ctdspl CTD (carboxy-terminal domain, RNA NM_133710 polymerase II, polypeptide A) small phosphatase-like (Ctdspl), mRNA. 6865949 -0.53077 0.004642 Tcof1 Treacher Collins Franceschetti syndrome NM_011552 1, homolog (Tcof1), mRNA. 6792756 -0.53078 3.44E-05 2310003H01Ri RIKEN cDNA 2310003H01 gene NM_027980 k (2310003H01Rik), mRNA. 6929861 -0.53102 3.8E-06 Rgs12 regulator of G-protein signaling 12 NM_173402 (Rgs12), transcript variant 1, mRNA. 6943476 -0.5313 0.002595 Rbm47 RNA binding motif protein 47 (Rbm47), NM_178446 transcript variant 1, mRNA. 6919932 -0.53133 0.009415 Osgin2 oxidative stress induced growth inhibitor NM_145950 family member 2 (Osgin2), mRNA. 6763810 -0.53178 0.004456 Pou2f1 POU domain, class 2, transcription factor 1 NM_198934 (Pou2f1), transcript variant 4, mRNA.

6934321 -0.53292 0.007968 Gtf2h3 general transcription factor IIH, polypeptide NM_181410 3 (Gtf2h3), mRNA. 6861260 -0.5338 0.005858 Isoc1 isochorismatase domain containing 1 NM_025478 (Isoc1), mRNA. 6981108 -0.53398 0.000885 Adam9 a disintegrin and metallopeptidase domain NM_007404 9 (meltrin gamma) (Adam9), mRNA.

6856238 -0.5341 0.003047 2410015M20Ri RIKEN cDNA 2410015M20 gene NM_153152 k (2410015M20Rik), mRNA. 6971271 -0.53497 0.004998 Atxn2l ataxin 2-like (Atxn2l), mRNA. NM_183020 6882272 -0.53507 0.00788 Csnk2a1 casein kinase 2, alpha 1 polypeptide NM_007788 (Csnk2a1), mRNA. 6758633 -0.53622 0.001174 Mfsd6 major facilitator superfamily domain NM_133829 containing 6 (Mfsd6), transcript variant 1, mRNA. 6937069 -0.53691 0.007256 Eif2b4 eukaryotic translation initiation factor 2B, NM_001127356 subunit 4 delta (Eif2b4), transcript variant 1, mRNA. 6970851 -0.53781 0.0011 2310008H09Ri RIKEN cDNA 2310008H09 gene NM_023197 k (2310008H09Rik), transcript variant 1, mRNA. 6984991 -0.53784 0.000828 E130303B06Ri RIKEN cDNA E130303B06 gene, mRNA BC052498 k (cDNA clone MGC:62932 IMAGE:1245862), complete cds. 6763520 -0.53811 0.000482 Dars2 aspartyl-tRNA synthetase 2 (mitochondrial) NM_172644 (Dars2), nuclear gene encoding mitochondrial protein, mRNA. 6985886 -0.53843 0.004228 Klhdc4 kelch domain containing 4 (Klhdc4), NM_145605 mRNA. 6850780 -0.53848 0.000417 Mrps10 mitochondrial ribosomal protein S10 NM_001146212 (Mrps10), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6995938 -0.53877 0.003289 Arid3b AT rich interactive domain 3B (BRIGHT- NM_019689 like) (Arid3b), mRNA. 6977971 -0.53934 0.009905 Heatr3 HEAT repeat containing 3 (Heatr3), mRNA. NM_172757

6941761 -0.54012 0.000734 Camkk2 calcium/calmodulin-dependent protein NM_145358 kinase kinase 2, beta (Camkk2), mRNA. 6846393 -0.5403 0.007422 Rg9mtd1 RNA (guanine-9-) methyltransferase NM_029092 domain containing 1 (Rg9mtd1), nuclear gene encoding mitochondrial protein, mRNA. 6983222 -0.54077 0.008891 Mpv17l2 MPV17 mitochondrial membrane protein- NM_183170 like 2 (Mpv17l2), nuclear gene encoding mitochondrial protein, mRNA. 6766835 -0.54078 2.11E-05 Ptprk protein tyrosine phosphatase, receptor NM_008983 type, K (Ptprk), mRNA. 6844291 -0.54108 0.004291 Med15 mediator complex subunit 15 (Med15), NM_033609 transcript variant 1, mRNA. 6993000 -0.54148 1.81E-06 Deb1 differentially expressed in B16F10 1 NM_026794 (Deb1), mRNA. 6862251 -0.54198 0.000188 Hdhd2 haloacid dehalogenase-like hydrolase NM_001039201 domain containing 2 (Hdhd2), transcript variant 2, mRNA. 6925594 -0.54202 0.001492 Tmem39b transmembrane protein 39b (Tmem39b), NM_199305 mRNA. 6794360 -0.54227 0.002912 Twist1 twist homolog 1 (Drosophila) (Twist1), NM_011658 mRNA. 6833057 -0.5424 0.003723 Pfkm phosphofructokinase, muscle (Pfkm), NM_001163487 transcript variant 1, mRNA. 6917835 -0.54328 0.001708 Luzp1 leucine zipper protein 1 (Luzp1), mRNA. NM_024452 6778028 -0.54334 0.001691 Obfc2b oligonucleotide/oligosaccharide-binding NM_027257 fold containing 2B (Obfc2b), mRNA. 6977068 -0.5434 1.5E-06 Ankle1 ankyrin repeat and LEM domain containing NM_172756 1 (Ankle1), mRNA. 6769461 -0.54402 0.006773 AI597468 expressed sequence AI597468 NM_001013028 (AI597468), mRNA. 6840586 -0.54436 0.007357 Tnk2 tyrosine kinase, non-receptor, 2 (Tnk2), NM_016788 transcript variant 1, mRNA. 6899767 -0.54592 0.00275 Itga10 integrin, alpha 10 (Itga10), mRNA. NM_001081053 6967068 -0.5467 0.007003 Hps5 Hermansky-Pudlak syndrome 5 homolog NM_001005247 (human) (Hps5), transcript variant 1, mRNA. 6789813 -0.54696 2.89E-06 Nxn nucleoredoxin (Nxn), mRNA. NM_008750 6971344 -0.54712 0.000545 Dctpp1 dCTP pyrophosphatase 1 (Dctpp1), NM_023203 mRNA. 6849467 -0.54713 0.00246 Bnip1 BCL2/adenovirus E1B interacting protein 1 NM_172149 (Bnip1), mRNA. 6775335 -0.54724 0.007385 Polr2e polymerase (RNA) II (DNA directed) NM_025554 polypeptide E (Polr2e), mRNA. 6819573 -0.54891 0.007066 Mipep mitochondrial intermediate peptidase NM_027436 (Mipep), nuclear gene encoding mitochondrial protein, mRNA. 6791656 -0.54909 0.003915 Dcakd dephospho-CoA kinase domain containing NM_026551 (Dcakd), mRNA. 6855785 -0.5501 0.00782 Tomm6 translocase of outer mitochondrial NM_001164729 membrane 6 homolog (yeast) (Tomm6), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6942688 -0.55031 0.002321 Ints1 integrator complex subunit 1 (Ints1), NM_026748 mRNA. 6750608 -0.5506 0.001883 Ankzf1 ankyrin repeat and zinc finger domain NM_026187 containing 1 (Ankzf1), mRNA. 6995817 -0.5507 1.88E-05 Etfa electron transferring flavoprotein, alpha NM_145615 polypeptide (Etfa), nuclear gene encoding mitochondrial protein, mRNA. 6934894 -0.55139 0.002865 Dnajc30 DnaJ (Hsp40) homolog, subfamily C, NM_025362 member 30 (Dnajc30), mRNA. 6966137 -0.55161 0.000789 Timm50 translocase of inner mitochondrial NM_025616 membrane 50 homolog (yeast) (Timm50), nuclear gene encoding mitochondrial protein, mRNA. 6940005 -0.55224 0.004435 Nup54 nucleoporin 54 (Nup54), mRNA. NM_183392 6760911 -0.55289 0.005896 D1Ertd622e DNA segment, Chr 1, ERATO Doi 622, NM_133825 expressed (D1Ertd622e), mRNA. 6769080 -0.55347 0.007289 Cstb cystatin B (Cstb), mRNA. NM_007793 6749103 -0.55361 0.000249 Bivm basic, immunoglobulin-like variable motif NM_144558 containing (Bivm), mRNA. 6866002 -0.55464 2.35E-05 Pcyox1l prenylcysteine oxidase 1 like (Pcyox1l), NM_172832 mRNA. 6984908 -0.55465 0.000345 Gm9853 ENSMUSG00000051554 protein ENSMUST00000060171 gene:ENSMUSG00000051554 7018546 -0.55558 0.003545 Zmym3 zinc finger, MYM-type 3 (Zmym3), NM_001177985 transcript variant 2, mRNA. 6819425 -0.55567 9.24E-05 Mrp63 mitochondrial ribosomal protein 63 NM_026401 (Mrp63), nuclear gene encoding mitochondrial protein, mRNA. 6749108 -0.55791 0.00216 Ercc5 excision repair cross-complementing NM_011729 rodent repair deficiency, complementation group 5 (Ercc5), mRNA.

6977697 -0.55848 0.005439 Prkaca protein kinase, cAMP dependent, catalytic, NM_008854 alpha (Prkaca), mRNA. 6927291 -0.55882 0.002902 Atad3a ATPase family, AAA domain containing 3A NM_179203 (Atad3a), nuclear gene encoding mitochondrial protein, mRNA. 6997349 -0.55889 2.46E-05 Hmgn3 high mobility group nucleosomal binding NM_026122 domain 3 (Hmgn3), transcript variant a, mRNA. 6984071 -0.55892 0.002338 Snx20 sorting nexin 20 (Snx20), mRNA. NM_027840 6817617 -0.55903 0.007382 Ppif peptidylprolyl isomerase F (cyclophilin F) NM_134084 (Ppif), nuclear gene encoding mitochondrial protein, mRNA. 6759781 -0.55921 0.007601 Glb1l galactosidase, beta 1-like (Glb1l), mRNA. NM_029010

6776173 -0.55982 0.004564 Cradd CASP2 and RIPK1 domain containing NM_009950 adaptor with death domain (Cradd), mRNA. 6854239 -0.56034 0.001884 Zfp40 zinc finger protein 40 (Zfp40), mRNA. NM_009555 6966922 -0.56046 0.005641 Prmt1 protein arginine N-methyltransferase 1 NM_019830 (Prmt1), mRNA. 6963856 -0.56071 0.005922 6330503K22Ri RIKEN cDNA 6330503K22 gene NM_182995 k (6330503K22Rik), mRNA. 6814666 -0.56162 0.000129 Polr3g polymerase (RNA) III (DNA directed) NM_001081176 polypeptide G (Polr3g), mRNA. 6825683 -0.56226 0.000599 Pdlim2 PDZ and LIM domain 2 (Pdlim2), mRNA. NM_145978 6831847 -0.56268 0.004666 Gga1 golgi associated, gamma adaptin ear NM_145929 containing, ARF binding protein 1 (Gga1), mRNA. 6866305 -0.56389 4.65E-05 Spire1 spire homolog 1 (Drosophila) (Spire1), NM_194355 transcript variant 1, mRNA. 6980526 -0.56389 6.09E-06 Grtp1 GH regulated TBC protein 1 (Grtp1), NM_025768 mRNA. 6940361 -0.56394 0.000442 Coq2 coenzyme Q2 homolog, prenyltransferase NM_027978 (yeast) (Coq2), nuclear gene encoding mitochondrial protein, mRNA.

6801560 -0.56433 0.00339 Timm9 translocase of inner mitochondrial NM_013896 membrane 9 homolog (yeast) (Timm9), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6990683 -0.56488 0.006145 Ick intestinal cell kinase (Ick), transcript variant NM_019987 2, mRNA. 6937364 -0.56508 0.003049 Lrpap1 low density lipoprotein receptor-related NM_013587 protein associated protein 1 (Lrpap1), mRNA. 6800912 -0.56599 5.19E-05 2700097O09Ri RIKEN cDNA 2700097O09 gene NR_030764 k (2700097O09Rik), transcript variant 2, non- coding RNA. 6855149 -0.56602 0.003559 Abcf1 ATP-binding cassette, sub-family F NM_013854 (GCN20), member 1 (Abcf1), mRNA. 6959568 -0.56619 0.00052 Polr2i polymerase (RNA) II (DNA directed) NM_027259 polypeptide I (Polr2i), mRNA. 6901489 -0.56679 0.008346 Ints12 integrator complex subunit 12 (Ints12), NM_027927 mRNA. 6790239 -0.56719 0.002868 Slfn9 schlafen 9 (Slfn9), mRNA. NM_172796 6966267 -0.56743 0.000315 Wdr62 WD repeat domain 62 (Wdr62), mRNA. NM_146186 6952665 -0.56752 0.002873 Cnot4 CCR4-NOT transcription complex, subunit NM_016877 4 (Cnot4), transcript variant 2, mRNA. 6764048 -0.56897 0.004237 Tomm40l translocase of outer mitochondrial NM_001037170 membrane 40 homolog-like (yeast) (Tomm40l), nuclear gene encoding mitochondrial protein, mRNA. 6775480 -0.56921 0.007333 Sirt6 sirtuin 6 (silent mating type information NM_181586 regulation 2, homolog) 6 (S. cerevisiae) (Sirt6), transcript variant 1, mRNA. 6850192 -0.56971 0.004225 Flot1 flotillin 1 (Flot1), mRNA. NM_008027 6925802 -0.57024 0.008246 Dnajc8 DnaJ (Hsp40) homolog, subfamily C, NM_172400 member 8 (Dnajc8), mRNA. 6893288 -0.57049 1.73E-05 Atp9a ATPase, class II, type 9A (Atp9a), mRNA. NM_015731

6784785 -0.57052 0.005994 Amz2 archaelysin family metallopeptidase 2 NM_025275 (Amz2), mRNA. 6837507 -0.57166 0.001004 Ldoc1l leucine zipper, down-regulated in cancer 1- NM_177630 like (Ldoc1l), mRNA. 6965206 -0.57171 2.98E-05 Tspan4 tetraspanin 4 (Tspan4), mRNA. NM_053082 6791439 -0.57192 0.008047 Kat2a K(lysine) acetyltransferase 2A (Kat2a), NM_020004 transcript variant 1, mRNA. 6785935 -0.57196 0.00709 Hus1 Hus1 homolog (S. pombe) (Hus1), mRNA. NM_008316

6837453 -0.57225 0.006517 Ttll12 tubulin tyrosine ligase-like family, member NM_183017 12 (Ttll12), mRNA. 6994624 -0.57227 0.000923 Hyls1 hydrolethalus syndrome 1 (Hyls1), mRNA. NM_029762

6965153 -0.57283 0.000841 B4galnt4 beta-1,4-N-acetyl-galactosaminyl NM_177897 transferase 4 (B4galnt4), mRNA. 6754666 -0.57287 0.003496 Kifap3 kinesin-associated protein 3 (Kifap3), NM_010629 mRNA. 6997109 -0.57368 0.000944 E330016A19Ri RIKEN cDNA E330016A19 gene, mRNA BC052196 k (cDNA clone MGC:59605 IMAGE:6510706), complete cds. 6974153 -0.57376 0.000362 Tmco3 transmembrane and coiled-coil domains 3 NM_172282 (Tmco3), mRNA. 6768978 -0.57406 0.000253 Pofut2 protein O-fucosyltransferase 2 (Pofut2), NM_030262 mRNA. 6971029 -0.57413 7.35E-05 Palb2 partner and localizer of BRCA2 (Palb2), NM_001081238 mRNA. 6990859 -0.57415 3.95E-05 Irak1bp1 interleukin-1 receptor-associated kinase 1 NM_022986 binding protein 1 (Irak1bp1), transcript variant 1, mRNA. 6789448 -0.57422 0.003951 Camta2 calmodulin binding transcription activator 2 NM_178116 (Camta2), transcript variant 1, mRNA. 6917506 -0.57425 0.003197 Med18 mediator of RNA polymerase II NM_026039 transcription, subunit 18 homolog (yeast) (Med18), mRNA. 6893635 -0.57475 0.004824 Atp5e ATP synthase, H+ transporting, NM_025983 mitochondrial F1 complex, epsilon subunit (Atp5e), nuclear gene encoding mitochondrial protein, mRNA. 6995233 -0.57586 0.002402 Cep164 centrosomal protein 164 (Cep164), mRNA. NM_001081373

6978314 -0.57647 0.006392 Herpud1 homocysteine-inducible, endoplasmic NM_022331 reticulum stress-inducible, ubiquitin-like domain member 1 (Herpud1), mRNA. 6753058 -0.57665 0.000747 Fam72a RIKEN cDNA 2700049P18 gene, mRNA BC090647 (cDNA clone MGC:116018 IMAGE:30633261), complete cds. 6925076 -0.57686 0.000612 Dem1 defects in morphology 1 homolog (S. NM_028457 cerevisiae) (Dem1), transcript variant 1, mRNA. 6954611 -0.57746 0.007719 Usp39 ubiquitin specific peptidase 39 (Usp39), NM_138592 mRNA. 6882775 -0.57755 0.000584 Dhx35 DEAH (Asp-Glu-Ala-His) box polypeptide NM_145742 35 (Dhx35), mRNA. 6832321 -0.57793 0.004537 Prr5 proline rich 5 (renal) (Prr5), mRNA. NM_146061 6749817 -0.57811 0.009871 Abi2 abl-interactor 2 (Abi2), transcript variant 2, NM_001198571 mRNA. 6855712 -0.57827 0.00073 Rrp36 ribosomal RNA processing 36 homolog (S. NM_144857 cerevisiae) (Rrp36), mRNA. 6881341 -0.57882 0.001675 Crls1 cardiolipin synthase 1 (Crls1), transcript NM_001024385 variant 1, mRNA. 6959448 -0.57921 0.001231 Sars2 seryl-aminoacyl-tRNA synthetase 2 NM_023637 (Sars2), mRNA. 6959099 -0.57946 0.004344 Zfp93 zinc finger protein 93 (Zfp93), mRNA. NM_009567 6860666 -0.57955 0.001022 Commd10 COMM domain containing 10 (Commd10), NM_178377 mRNA. 6956552 -0.58011 0.000228 Tada3 transcriptional adaptor 3 (Tada3), mRNA. NM_133932

6798309 -0.58062 0.000907 Pacs2 phosphofurin acidic cluster sorting protein NM_001081170 2 (Pacs2), mRNA. 6774238 -0.58067 0.000102 Oit3 oncoprotein induced transcript 3 (Oit3), NM_010959 mRNA. 6878984 -0.5809 0.006674 Fnbp4 formin binding protein 4 (Fnbp4), mRNA. NM_018828 6764401 -0.58098 0.009776 Cep170 centrosomal protein 170 (Cep170), mRNA. NM_001099637

6959309 -0.58125 5.65E-05 2310022A10Ri RIKEN cDNA 2310022A10 gene NM_175107 k (2310022A10Rik), transcript variant 1, mRNA. 6937333 -0.58158 0.00099 Mfsd10 major facilitator superfamily domain NM_026660 containing 10 (Mfsd10), mRNA. 6818053 -0.58174 0.006247 Oxnad1 oxidoreductase NAD-binding domain NM_145460 containing 1 (Oxnad1), mRNA. 6875901 -0.58177 0.001309 Rxra retinoid X receptor alpha (Rxra), mRNA. NM_011305 6859937 -0.58198 0.007276 Srp19 signal recognition particle 19 (Srp19), NM_025527 mRNA. 6959228 -0.58243 0.009814 Exosc5 exosome component 5 (Exosc5), mRNA. NM_138586

6947460 -0.58246 0.000542 Nagk N-acetylglucosamine kinase (Nagk), NM_001164187 transcript variant 2, mRNA. 6789445 -0.58259 0.008132 Spag7 sperm associated antigen 7 (Spag7), NM_172561 transcript variant 1, mRNA. 6916511 -0.58272 0.009003 Mknk1 MAP kinase-interacting serine/threonine NM_021461 kinase 1 (Mknk1), mRNA. 6887089 -0.58367 0.007628 Rbms1 RNA binding motif, single stranded NM_001141932 interacting protein 1 (Rbms1), transcript variant 1, mRNA. 6900090 -0.58409 0.005915 Nras neuroblastoma ras oncogene (Nras), NM_010937 mRNA. 6983782 -0.58427 0.007015 Scoc short coiled-coil protein (Scoc), transcript NM_001039137 variant 1, mRNA. 6955223 -0.58428 0.008881 Snrnp27 small nuclear ribonucleoprotein 27 NM_025665 (U4/U6.U5) (Snrnp27), mRNA. 6885532 -0.58435 0.001116 Brd3 bromodomain containing 3 (Brd3), NM_001113574 transcript variant 1, mRNA. 6953639 -0.58478 1.42E-06 Jazf1 JAZF zinc finger 1 (Jazf1), transcript NM_001168277 variant 2, mRNA. 6780777 -0.58502 0.001332 Rnf130 ring finger protein 130 (Rnf130), mRNA. NM_021540 6874085 -0.58504 2.83E-05 4930506M07Ri RIKEN cDNA 4930506M07 gene NM_001114312 k (4930506M07Rik), transcript variant 1, mRNA. 6849294 -0.58529 0.001018 Pgp phosphoglycolate phosphatase (Pgp), NM_025954 mRNA. 6921158 -0.58529 0.001316 E130306D19Ri RIKEN cDNA E130306D19 gene NM_001013377 k (E130306D19Rik), mRNA. 6924247 -0.5853 0.001133 Acot11 acyl-CoA thioesterase 11 (Acot11), mRNA. NM_025590

6910610 -0.58586 0.000609 Gipc2 GIPC PDZ domain containing family, NM_016867 member 2 (Gipc2), mRNA. 6876543 -0.58602 0.001238 Nek6 NIMA (never in mitosis gene a)-related NM_001159631 expressed kinase 6 (Nek6), transcript variant 1, mRNA. 6933652 -0.58618 0.00338 Pop5 processing of precursor 5, ribonuclease NM_026398 P/MRP family (S. cerevisiae) (Pop5), mRNA. 6942458 -0.58627 0.002508 Tmem120a transmembrane protein 120A NM_172541 (Tmem120a), mRNA. 6983286 -0.58637 0.009273 Fcho1 FCH domain only 1 (Fcho1), transcript NR_028267 variant 2, non-coding RNA. 6958833 -0.58645 0.001552 Kptn kaptin (Kptn), mRNA. NM_133727 6792808 -0.58689 0.008906 Stra13 stimulated by retinoic acid 13 (Stra13), NM_016665 mRNA. 7011040 -0.58691 5.58E-06 Bcorl1 BCL6 co-repressor-like 1 (Bcorl1), mRNA. NM_178782

6871091 -0.58704 0.006599 Sf3b2 splicing factor 3b, subunit 2 (Sf3b2), NM_030109 mRNA. 6792296 -0.58821 0.000113 Slc39a11 solute carrier family 39 (metal ion NM_001166503 transporter), member 11 (Slc39a11), transcript variant 1, mRNA. 6933852 -0.58861 0.009752 Med13l mediator complex subunit 13-like (Med13l), NM_172424 mRNA. 6995120 -0.58924 2.28E-05 Phldb1 pleckstrin homology-like domain, family B, NM_153537 member 1 (Phldb1), mRNA. 6824744 -0.59027 0.00061 4931414P19Ri RIKEN cDNA 4931414P19 gene, mRNA BC029624 k (cDNA clone MGC:25751 IMAGE:3992239), complete cds. 6965317 -0.59027 0.005783 Tssc4 tumor-suppressing subchromosomal NM_020285 transferable fragment 4 (Tssc4), transcript variant 1, mRNA. 6934397 -0.59034 0.008409 Bri3bp Bri3 binding protein (Bri3bp), mRNA. NM_029752 6850723 -0.59063 0.005401 Mea1 male enhanced antigen 1 (Mea1), mRNA. NM_010787

6838746 -0.59102 0.002139 Map3k12 mitogen-activated protein kinase kinase NM_001163643 kinase 12 (Map3k12), transcript variant 1, mRNA. 6897337 -0.5913 0.000289 Ccrn4l CCR4 carbon catabolite repression 4-like NM_009834 (S. cerevisiae) (Ccrn4l), mRNA. 6811724 -0.59204 0.001046 Lrrc16a leucine rich repeat containing 16A NM_026825 (Lrrc16a), mRNA. 6988707 -0.59207 0.003548 Mpzl3 myelin protein zero-like 3 (Mpzl3), NM_176993 transcript variant 1, mRNA. 6998094 -0.59219 0.000407 Acpl2 acid phosphatase-like 2 (Acpl2), mRNA. NM_153420 6854414 -0.59243 0.002487 Gnptg N-acetylglucosamine-1- NM_172529 phosphotransferase, gamma subunit (Gnptg), mRNA. 6849068 -0.59271 8.68E-05 Zfp54 zinc finger protein 54 (Zfp54), mRNA. NM_011760 6849536 -0.59304 0.000552 Ppard peroxisome proliferator activator receptor NM_011145 delta (Ppard), mRNA. 6892374 -0.59372 1.73E-05 Ggt7 gamma-glutamyltransferase 7 (Ggt7), NM_144786 mRNA. 6870978 -0.5939 0.00043 Rps6kb2 ribosomal protein S6 kinase, polypeptide 2 NM_021485 (Rps6kb2), mRNA. 7019519 -0.59418 0.002338 Gla galactosidase, alpha (Gla), mRNA. NM_013463 6812505 -0.59439 0.006075 Txndc5 thioredoxin domain containing 5 (Txndc5), NM_145367 mRNA. 6784207 -0.59457 0.000482 Nkiras2 NFKB inhibitor interacting Ras-like protein NM_028024 2 (Nkiras2), mRNA. 6854384 -0.59481 0.001634 Gfer growth factor, erv1 (S. cerevisiae)-like NM_023040 (augmenter of liver regeneration) (Gfer), mRNA. 6769268 -0.59542 0.006867 Dapk3 death-associated protein kinase 3 (Dapk3), NM_001190474 transcript variant 1, mRNA. 6884262 -0.59545 0.001571 Rtel1 regulator of telomere elongation helicase 1 NM_001001882 (Rtel1), transcript variant 1, mRNA. 6878430 -0.59582 0.000534 Ube2e3 ubiquitin-conjugating enzyme E2E 3, NM_009454 UBC4/5 homolog (yeast) (Ube2e3), mRNA.

6893186 -0.59594 0.003434 Ube2v1 ubiquitin-conjugating enzyme E2 variant 1 NM_023230 (Ube2v1), mRNA. 6929604 -0.59611 0.009784 Ept1 ethanolaminephosphotransferase 1 (CDP- NM_027652 ethanolamine-specific) (Ept1), mRNA.

6972115 -0.59625 0.000153 1810014F10Ri RIKEN cDNA 1810014F10 gene NM_026928 k (1810014F10Rik), mRNA. 6769917 -0.59695 1.4E-05 Fgd6 FYVE, RhoGEF and PH domain containing NM_053072 6 (Fgd6), mRNA. 6983327 -0.59699 0.003836 Cherp calcium homeostasis endoplasmic NM_138585 reticulum protein (Cherp), mRNA. 6963578 -0.597 0.004599 Far1 fatty acyl CoA reductase 1 (Far1), NM_026143 transcript variant 1, mRNA. 6957632 -0.59713 0.004261 Mansc1 MANSC domain containing 1 (Mansc1), NM_026345 mRNA. 6819683 -0.59721 0.001931 Wdfy2 WD repeat and FYVE domain containing 2 NM_175546 (Wdfy2), mRNA. 6935269 -0.59735 0.001065 Nudt1 nudix (nucleoside diphosphate linked NM_008637 moiety X)-type motif 1 (Nudt1), mRNA. 6986032 -0.59784 0.004122 Nup133 nucleoporin 133 (Nup133), mRNA. NM_172288 6831709 -0.59805 0.00118 1110038F14Ri RIKEN cDNA 1110038F14 gene, mRNA BC038324 k (cDNA clone MGC:48178 IMAGE:1511597), complete cds. 6785558 -0.59822 0.004691 Metrnl meteorin, glial cell differentiation regulator- NM_144797 like (Metrnl), mRNA. 6950688 -0.59875 0.00199 Aebp2 AE binding protein 2 (Aebp2), transcript NM_001005605 variant 1, mRNA. 6986086 -0.59881 0.000525 2810004N23Ri RIKEN cDNA 2810004N23 gene NM_025615 k (2810004N23Rik), mRNA. 6979543 -0.59888 0.002928 Gse1 genetic suppressor element 1 (Gse1), NM_001145896 transcript variant 2, mRNA. 6985108 -0.5995 0.000544 Nob1 NIN1/RPN12 binding protein 1 homolog (S. NM_026277 cerevisiae) (Nob1), mRNA. 6909181 -0.59981 0.002534 Ap1ar adaptor-related protein complex 1 NM_145964 associated regulatory protein (Ap1ar), mRNA. 6788794 -0.59997 0.00048 Tmem11 transmembrane protein 11 (Tmem11), NM_001168507 transcript variant 2, mRNA. 6906830 -0.60016 4.33E-06 Adam15 a disintegrin and metallopeptidase domain NM_001037722 15 (metargidin) (Adam15), transcript variant 1, mRNA. 6989355 -0.60054 0.005233 Snupn snurportin 1 (Snupn), mRNA. NM_178374 6882774 -0.60074 8.15E-05 Fam83d family with sequence similarity 83, member BC068129 D, mRNA (cDNA clone MGC:92947 IMAGE:6411705), complete cds.

6789378 -0.60082 0.002675 Acadvl acyl-Coenzyme A dehydrogenase, very NM_017366 long chain (Acadvl), nuclear gene encoding mitochondrial protein, mRNA. 6790359 -0.60093 0.009808 Dhrs11 dehydrogenase/reductase (SDR family) NM_177564 member 11 (Dhrs11), mRNA. 6962876 -0.60097 0.000122 Gdpd5 glycerophosphodiester phosphodiesterase NM_201352 domain containing 5 (Gdpd5), mRNA.

6804703 -0.60134 6.69E-05 U2af2 U2 small nuclear ribonucleoprotein NM_133671 auxiliary factor (U2AF) 2 (U2af2), mRNA.

6878347 -0.60138 0.00266 Plekha3 pleckstrin homology domain-containing, NM_031256 family A (phosphoinositide binding specific) member 3 (Plekha3), mRNA. 6899250 -0.60144 0.00235 Pygo2 pygopus 2 (Pygo2), mRNA. NM_026869 6850118 -0.60224 0.000922 D17H6S53E DNA segment, Chr 17, human D6S53E NM_033477 (D17H6S53E), mRNA. 6775430 -0.60225 0.000994 Pias4 protein inhibitor of activated STAT 4 NM_021501 (Pias4), mRNA. 6915036 -0.60318 0.000189 Cntln centlein, centrosomal protein (Cntln), NM_177385 transcript variant 2, mRNA. 6844196 -0.60387 0.005589 Dnm1l dynamin 1-like (Dnm1l), transcript variant NM_152816 1, mRNA. 6807899 -0.60404 3.88E-06 Fastkd3 FAST kinase domains 3 (Fastkd3), mRNA. NM_027123

6763754 -0.60413 0.005533 Tiprl TIP41, TOR signalling pathway regulator- NM_145513 like (S. cerevisiae) (Tiprl), mRNA. 6851320 -0.60473 0.000511 Trip10 thyroid hormone receptor interactor 10 NM_134125 (Trip10), mRNA. 6966152 -0.60505 0.005663 Samd4b sterile alpha motif domain containing 4B NM_175021 (Samd4b), mRNA. 6861136 -0.60546 0.00303 Phax phosphorylated adaptor for RNA export NM_019996 (Phax), transcript variant 1, mRNA. 6782572 -0.60647 0.002859 Git1 G protein-coupled receptor kinase- NM_001004144 interactor 1 (Git1), mRNA. 6799849 -0.60659 0.008353 Bcap29 B-cell receptor-associated protein 29 NM_007530 (Bcap29), transcript variant 1, mRNA. 6883273 -0.60716 0.008473 Ddx27 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_153065 27 (Ddx27), mRNA. 6803912 -0.60731 0.005085 Cdca4 cell division cycle associated 4 (Cdca4), NM_028023 mRNA. 6788303 -0.60756 4.06E-05 Slc22a21 solute carrier family 22 (organic cation NM_019723 transporter), member 21 (Slc22a21), mRNA. 6997994 -0.60784 0.007587 2610101N10Ri RIKEN cDNA 2610101N10 gene NM_001114977 k (2610101N10Rik), transcript variant 1, mRNA. 6789817 -0.60797 0.003451 Abr active BCR-related gene (Abr), transcript NM_198018 variant 1, mRNA. 6880033 -0.6081 0.007248 Lpcat4 lysophosphatidylcholine acyltransferase 4 NM_207206 (Lpcat4), mRNA. 6924784 -0.6082 0.001483 Mast2 microtubule associated serine/threonine NM_001042743 kinase 2 (Mast2), transcript variant 1, mRNA. 6760774 -0.60893 5.3E-06 Pask PAS domain containing serine/threonine NM_080850 kinase (Pask), mRNA. 6792527 -0.60961 0.000301 Ube2o ubiquitin-conjugating enzyme E2O NM_173755 (Ube2o), mRNA. 6978319 -0.60967 2.16E-05 Cpne2 copine II (Cpne2), mRNA. NM_153507 6855722 -0.60973 0.000986 Cnpy3 canopy 3 homolog (zebrafish) (Cnpy3), NM_028065 mRNA. 6875792 -0.60988 0.006948 Pmpca peptidase (mitochondrial processing) alpha NM_173180 (Pmpca), nuclear gene encoding mitochondrial protein, mRNA. 6970846 -0.61007 0.008722 Gde1 glycerophosphodiester phosphodiesterase NM_019580 1 (Gde1), mRNA. 6848505 -0.61011 0.001384 Synj2 synaptojanin 2 (Synj2), transcript variant 1, NM_001113353 mRNA. 6933675 -0.61012 0.003099 Pxn paxillin (Pxn), transcript variant alpha, NM_011223 mRNA. 6845141 -0.61013 0.008211 Senp5 SUMO/sentrin specific peptidase 5 NM_177103 (Senp5), mRNA. 6921350 -0.61161 0.002428 Tstd2 thiosulfate sulfurtransferase (rhodanese)- NM_173033 like domain containing 2 (Tstd2), mRNA. 6850265 -0.61172 5.95E-06 Znrd1as ZNRD1 antisense RNA (Znrd1as), mRNA. NM_029602

6971393 -0.61183 0.002852 Bcl7c B-cell CLL/lymphoma 7C (Bcl7c), mRNA. NM_009746

6982155 -0.612 0.007718 Snx25 sorting nexin 25 (Snx25), mRNA. NM_207213 6810688 -0.61215 0.000371 Net1 neuroepithelial cell transforming gene 1 NM_019671 (Net1), transcript variant 1, mRNA. 6840805 -0.61255 0.009737 Rabl3 RAB, member of RAS oncogene family-like NM_001042499 3 (Rabl3), mRNA. 6809447 -0.61269 0.000322 Mrps27 mitochondrial ribosomal protein S27 NM_173757 (Mrps27), nuclear gene encoding mitochondrial protein, mRNA. 6756474 -0.61306 0.000333 A130010J15Ri RIKEN cDNA A130010J15 gene NM_181048 k (A130010J15Rik), transcript variant 1, mRNA. 6903095 -0.61316 0.000932 Mrps28 // mitochondrial ribosomal protein S28 NM_025434 Mrps28 (Mrps28), nuclear gene encoding mitochondrial protein, mRNA. 6788676 -0.61316 0.006729 Zkscan17 zinc finger with KRAB and SCAN domains NM_172941 17 (Zkscan17), transcript variant 1, mRNA.

6870956 -0.61337 0.008615 Tcirg1 T-cell, immune regulator 1, ATPase, H+ NM_016921 transporting, lysosomal V0 protein A3 (Tcirg1), transcript variant 1, mRNA. 6803070 -0.61385 0.000134 2610021K21Ri RIKEN cDNA 2610021K21 gene NM_030172 k (2610021K21Rik), mRNA. 6838249 -0.61515 0.004827 Srsf2ip serine/arginine-rich splicing factor 2, NM_028148 interacting protein (Srsf2ip), mRNA. 6878694 -0.61586 0.004959 Med19 mediator of RNA polymerase II NM_025885 transcription, subunit 19 homolog (yeast) (Med19), mRNA. 6887861 -0.61614 0.009013 Atp5g3 ATP synthase, H+ transporting, NM_175015 mitochondrial F0 complex, subunit C3 (subunit 9) (Atp5g3), nuclear gene encoding mitochondrial protein, mRNA. 6791150 -0.61623 0.002801 Cdk5rap3 CDK5 regulatory subunit associated NM_030248 protein 3 (Cdk5rap3), mRNA. 6983788 -0.61624 0.006948 Tecr trans-2,3-enoyl-CoA reductase (Tecr), NM_134118 transcript variant 1, mRNA. 6917441 -0.61639 0.003851 Srsf4 serine/arginine-rich splicing factor 4 NM_020587 (Srsf4), mRNA. 6966298 -0.61694 0.000122 Zbtb32 zinc finger and BTB domain containing 32 NM_021397 (Zbtb32), mRNA. 6758450 -0.61696 0.004085 Slc39a10 solute carrier family 39 (zinc transporter), NM_172653 member 10 (Slc39a10), mRNA.

6940366 -0.61724 0.000716 Helq helicase, POLQ-like (Helq), mRNA. NM_001081107 6783297 -0.61763 0.007373 Trim37 tripartite motif-containing 37 (Trim37), NM_197987 mRNA. 7020677 -0.6178 0.000756 Siah1b seven in absentia 1B (Siah1b), mRNA. NM_009173 6992217 -0.6181 0.004922 Nprl2 nitrogen permease regulator-like 2 (S. NM_018879 cerevisiae) (Nprl2), mRNA. 6775449 -0.61823 0.00884 Mrpl54 mitochondrial ribosomal protein L54 NM_025317 (Mrpl54), nuclear gene encoding mitochondrial protein, mRNA. 7022815 -0.61855 0.009568 Srebf2 sterol regulatory element binding factor 2 NM_033218 (Srebf2), mRNA. 6843953 -0.61856 0.006177 Gspt1 G1 to S phase transition 1 (Gspt1), NM_146066 transcript variant 1, mRNA. 6840539 -0.61867 0.007766 Rnf168 ring finger protein 168 (Rnf168), mRNA. NM_027355 6789719 -0.61891 0.000734 Hic1 hypermethylated in cancer 1 (Hic1), NM_010430 transcript variant 1, mRNA. 6998407 -0.61921 0.001047 Tmem108 transmembrane protein 108 (Tmem108), NM_178638 mRNA. 6951107 -0.61938 0.00031 Arntl2 aryl hydrocarbon receptor nuclear NM_172309 translocator-like 2 (Arntl2), mRNA. 6941857 -0.61961 0.00014 Abcb9 ATP-binding cassette, sub-family B NM_019875 (MDR/TAP), member 9 (Abcb9), mRNA. 6880715 -0.61966 0.009036 Pldn pallidin (Pldn), mRNA. NM_019788 6971268 -0.62004 0.001402 Sh2b1 SH2B adaptor protein 1 (Sh2b1), transcript NM_011363 variant 2, mRNA. 6815027 -0.62047 0.00016 Rasgrf2 RAS protein-specific guanine nucleotide- NM_009027 releasing factor 2 (Rasgrf2), mRNA. 6871109 -0.62089 0.007093 Drap1 Dr1 associated protein 1 (negative cofactor NM_024176 2 alpha) (Drap1), mRNA. 7010327 -0.62114 0.001574 Phf16 PHD finger protein 16 (Phf16), mRNA. NM_199317 6878049 -0.62174 6.21E-05 B230120H23Ri RIKEN cDNA B230120H23 gene NM_001164791 k (B230120H23Rik), transcript variant 3, mRNA. 6802532 -0.62205 0.008798 Sptlc2 serine palmitoyltransferase, long chain NM_011479 base subunit 2 (Sptlc2), mRNA. 6925345 -0.62239 7.61E-06 1700029G01Ri RIKEN cDNA 1700029G01 gene NM_001162533 k (1700029G01Rik), transcript variant 1, mRNA. 6768866 -0.62296 0.008743 Snrpd3 small nuclear ribonucleoprotein D3 NM_026095 (Snrpd3), mRNA. 6833599 -0.62328 0.00069 Fbxo4 F-box protein 4 (Fbxo4), mRNA. NM_134099 6942554 -0.62347 0.000269 Pop7 processing of precursor 7, ribonuclease P NM_028753 family, (S. cerevisiae) (Pop7), mRNA. 6792491 -0.62478 0.002371 Unc13d unc-13 homolog D (C. elegans) (Unc13d), NM_001009573 mRNA. 6998640 -0.62508 0.007923 Gnai2 guanine nucleotide binding protein (G NM_008138 protein), alpha inhibiting 2 (Gnai2), mRNA.

6997288 -0.62561 0.001985 Htr1b 5-hydroxytryptamine (serotonin) receptor NM_010482 1B (Htr1b), mRNA. 6820896 -0.6261 0.005367 Tdrd3 tudor domain containing 3 (Tdrd3), mRNA. NM_172605

6788739 -0.62619 0.0001 Srebf1 sterol regulatory element binding NM_011480 transcription factor 1 (Srebf1), mRNA. 6916192 -0.62623 0.00468 Cc2d1b coiled-coil and C2 domain containing 1B NM_177045 (Cc2d1b), mRNA. 6857963 -0.62685 0.003141 Pigf phosphatidylinositol glycan anchor NM_008838 biosynthesis, class F (Pigf), mRNA. 6766455 -0.62729 0.003583 Sgk1 serum/glucocorticoid regulated kinase 1 NM_001161845 (Sgk1), transcript variant 1, mRNA. 6957346 -0.62731 0.009294 Fkbp4 FK506 binding protein 4 (Fkbp4), mRNA. NM_010219

6981592 -0.6275 0.004831 Ubxn8 UBX domain protein 8 (Ubxn8), mRNA. NM_178648 6960178 -0.62771 0.000439 Klk8 kallikrein related-peptidase 8 (Klk8), NM_008940 mRNA. 6845209 -0.62782 0.000264 Iqcg IQ motif containing G (Iqcg), mRNA. NM_178378 6825678 -0.62785 0.004868 2610301G19Ri RIKEN cDNA 2610301G19 gene NM_146055 k (2610301G19Rik), mRNA. 6902661 -0.62872 6.97E-06 Cryz crystallin, zeta (Cryz), mRNA. NM_009968 6934907 -0.62875 0.008375 Baz1b bromodomain adjacent to zinc finger NM_011714 domain, 1B (Baz1b), mRNA. 6951121 -0.62882 0.007681 Mrps35 mitochondrial ribosomal protein S35 NM_145573 (Mrps35), nuclear gene encoding mitochondrial protein, mRNA. 6796777 -0.62882 0.000273 Gstz1 glutathione transferase zeta 1 NM_010363 (maleylacetoacetate isomerase) (Gstz1), mRNA. 6917389 -0.62923 0.006336 Sdc3 syndecan 3 (Sdc3), mRNA. NM_011520 6781252 -0.62924 0.000176 Zfp692-ps zinc finger protein 692, pseudogene NM_182996 (Zfp692-ps), transcript variant 1, mRNA. 6850175 -0.62978 2.46E-06 Cchcr1 coiled-coil alpha-helical rod protein 1 NM_146248 (Cchcr1), mRNA. 6785746 -0.63036 0.003736 Polm polymerase (DNA directed), mu (Polm), NM_017401 mRNA. 6851200 -0.63124 0.00189 Mpnd MPN domain containing (Mpnd), mRNA. NM_026530 6977084 -0.63146 0.002321 Fam125a family with sequence similarity 125, NM_028617 member A (Fam125a), mRNA. 6878702 -0.63191 0.00081 Ypel4 yippee-like 4 (Drosophila) (Ypel4), mRNA. NM_001005342

6993754 -0.63214 0.001142 Keap1 kelch-like ECH-associated protein 1 NM_016679 (Keap1), transcript variant 1, mRNA. 6987348 -0.63339 0.003699 Mrpl4 mitochondrial ribosomal protein L4 (Mrpl4), NM_023167 nuclear gene encoding mitochondrial protein, mRNA. 6976954 -0.63373 0.002518 Atp13a1 ATPase type 13A1 (Atp13a1), mRNA. NM_133224 6942440 -0.63387 0.001043 Pom121 nuclear pore membrane protein 121 NM_148932 (Pom121), mRNA. 6881826 -0.63529 0.009684 Csrp2bp cysteine and glycine-rich protein 2 binding NM_181417 protein (Csrp2bp), transcript variant 1, mRNA. 6997671 -0.63529 0.001874 Tmed3 transmembrane emp24 domain containing NM_025360 3 (Tmed3), mRNA. 6977058 -0.63561 0.007431 Myo9b myosin IXb (Myo9b), transcript variant 1, NM_001142322 mRNA. 6802744 -0.63565 0.00746 Gtf2a1 general transcription factor II A, 1 (Gtf2a1), NM_031391 transcript variant 1, mRNA. 6947034 -0.63583 0.001656 Suclg1 succinate-CoA ligase, GDP-forming, alpha NM_019879 subunit (Suclg1), nuclear gene encoding mitochondrial protein, mRNA. 6889258 -0.63612 0.009608 Cd44 CD44 antigen (Cd44), transcript variant 1, NM_009851 mRNA. 6998858 -0.63699 0.000763 Klhl18 kelch-like 18 (Drosophila) (Klhl18), mRNA. NM_177771 6989044 -0.63869 0.006578 Alg9 asparagine-linked glycosylation 9 homolog NM_133981 (yeast, alpha 1,2 mannosyltransferase) (Alg9), mRNA. 6882050 -0.6388 0.001183 Nxt1 NTF2-related export protein 1 (Nxt1), NM_001110159 transcript variant 1, mRNA. 6797196 -0.63891 0.004868 Gpr65 G-protein coupled receptor 65 (Gpr65), NM_008152 mRNA. 6906742 -0.63903 0.00109 Pmf1 polyamine-modulated factor 1 (Pmf1), NM_025928 mRNA. 6918694 -0.63908 0.000705 Mthfr 5,10-methylenetetrahydrofolate reductase NM_001161798 (Mthfr), transcript variant 1, mRNA.

6983838 -0.63938 9.49E-05 D8Ertd738e DNA segment, Chr 8, ERATO Doi 738, NM_001007571 expressed (D8Ertd738e), mRNA. 6747837 -0.64028 0.000762 Tmem70 transmembrane protein 70 (Tmem70), NM_027415 nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6780963 -0.64056 0.004323 Aff4 AF4/FMR2 family, member 4 (Aff4), NM_033565 mRNA. 6867823 -0.64057 8.6E-05 Syvn1 synovial apoptosis inhibitor 1, synoviolin NM_028769 (Syvn1), transcript variant 1, mRNA. 6752885 -0.64165 0.003071 Ubxn4 UBX domain protein 4 (Ubxn4), mRNA. NM_026390 6885447 -0.64183 0.009171 Ubac1 ubiquitin associated domain containing 1 NM_133835 (Ubac1), mRNA. 6871496 -0.64195 0.000365 Tmem138 transmembrane protein 138 (Tmem138), NM_028411 mRNA. 6844000 -0.64221 0.008933 Cpped1 calcineurin-like phosphoesterase domain NM_146067 containing 1 (Cpped1), mRNA. 6871164 -0.64241 0.006434 Pola2 polymerase (DNA directed), alpha 2 NM_008893 (Pola2), transcript variant 1, mRNA. 6908048 -0.64269 0.000176 Csf1 colony stimulating factor 1 (macrophage) NM_007778 (Csf1), transcript variant 1, mRNA.

6969800 -0.64285 0.002261 Ppme1 protein phosphatase methylesterase 1 NM_028292 (Ppme1), mRNA. 6774400 -0.64307 0.007566 Srgn serglycin (Srgn), mRNA. NM_011157 6941675 -0.64316 0.003249 Erp29 endoplasmic reticulum protein 29 (Erp29), NM_026129 mRNA. 6956932 -0.64322 0.002887 Wnk1 WNK lysine deficient protein kinase 1 NM_198703 (Wnk1), transcript variant 1, mRNA. 6759732 -0.64374 0.001872 Tmbim1 transmembrane BAX inhibitor motif NM_027154 containing 1 (Tmbim1), mRNA. 6901634 -0.64396 9.87E-05 Slc39a8 solute carrier family 39 (metal ion NM_001135150 transporter), member 8 (Slc39a8), transcript variant 1, mRNA. 6779359 -0.64413 0.009075 Cct4 chaperonin containing Tcp1, subunit 4 NM_009837 (delta) (Cct4), mRNA. 6969886 -0.64445 9.47E-06 Inppl1 inositol polyphosphate phosphatase-like 1 NM_010567 (Inppl1), transcript variant 1, mRNA. 6864604 -0.64446 2.96E-05 Spata24 spermatogenesis associated 24 (Spata24), NM_027733 transcript variant 1, mRNA. 6925782 -0.64491 0.00413 Ythdf2 YTH domain family 2 (Ythdf2), mRNA. NM_145393 6885903 -0.64536 0.006827 Cdk9 cyclin-dependent kinase 9 (CDC2-related NM_130860 kinase) (Cdk9), mRNA. 6875662 -0.64537 0.003922 Zmynd19 zinc finger, MYND domain containing 19 NM_026021 (Zmynd19), mRNA. 6868058 -0.64579 0.000843 Slc15a3 solute carrier family 15, member 3 NM_023044 (Slc15a3), mRNA. 7018297 -0.64582 0.001514 Zc4h2 zinc finger, C4H2 domain containing NM_001003916 (Zc4h2), mRNA. 6799054 -0.64623 0.006342 Mycn v-myc myelocytomatosis viral related NM_008709 oncogene, neuroblastoma derived (avian) (Mycn), mRNA. 6855083 -0.64719 0.001627 Bat2 HLA-B associated transcript 2 (Bat2), NM_020027 mRNA. 6992164 -0.64723 6.02E-05 Poc1a POC1 centriolar protein homolog A NM_027354 (Chlamydomonas) (Poc1a), mRNA. 6837335 -0.6479 0.00181 Pppde2 PPPDE peptidase domain containing 2 NM_134095 (Pppde2), mRNA. 6846437 -0.64796 0.002532 Tfg Trk-fused gene (Tfg), mRNA. NM_019678 6932615 -0.64816 0.00708 Bmp2k BMP2 inducible kinase (Bmp2k), mRNA. NM_080708 6994585 -0.64842 0.002318 Dcps decapping enzyme, scavenger (Dcps), NM_027030 mRNA. 6829667 -0.64849 0.004698 Pop1 processing of precursor 1, ribonuclease NM_152894 P/MRP family, (S. cerevisiae) (Pop1), transcript variant 1, mRNA. 6863934 -0.64877 0.009371 Ino80c INO80 complex subunit C (Ino80c), mRNA. NM_172625

6785460 -0.64901 0.003645 Anapc11 anaphase promoting complex subunit 11 NM_001038230 (Anapc11), transcript variant 1, mRNA. 7013900 -0.64909 0.00996 Armcx1 armadillo repeat containing, X-linked 1 NM_001166377 (Armcx1), transcript variant 1, mRNA. 6929671 -0.64968 0.003799 Cad carbamoyl-phosphate synthetase 2, NM_023525 aspartate transcarbamylase, and dihydroorotase (Cad), mRNA. 6965980 -0.64991 0.001007 Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-NM_144922 like 1 (Hnrnpul1), transcript variant 1, mRNA. 6884351 -0.65018 1.99E-05 Suv39h2 suppressor of variegation 3-9 homolog 2 NM_022724 (Drosophila) (Suv39h2), transcript variant 1, mRNA. 6797391 -0.6502 0.003608 Calm1 calmodulin 1 (Calm1), mRNA. NM_009790 6775155 -0.65054 0.007396 Gstt2 glutathione S-transferase, theta 2 (Gstt2), NM_010361 mRNA. 6929125 -0.6506 0.004269 Fam185a family with sequence similarity 185, NM_177869 member A (Fam185a), mRNA. 6985655 -0.6507 0.001795 2310061C15Ri RIKEN cDNA 2310061C15 gene NM_026844 k (2310061C15Rik), mRNA. 6817403 -0.65139 0.008826 Myst4 MYST histone acetyltransferase monocytic NM_017479 leukemia 4 (Myst4), mRNA. 6946204 -0.65167 0.001153 Snx10 sorting nexin 10 (Snx10), transcript variant NM_028035 1, mRNA. 6836806 -0.65172 0.008849 Parp10 poly (ADP-ribose) polymerase family, NM_001163576 member 10 (Parp10), transcript variant 2, mRNA. 6929144 -0.65175 0.000399 Armc10 armadillo repeat containing 10 (Armc10), NM_026034 mRNA. 6867930 -0.65274 0.008155 Pla2g16 phospholipase A2, group XVI (Pla2g16), NM_139269 mRNA. 6873171 -0.65317 0.002068 Avpi1 arginine vasopressin-induced 1 (Avpi1), NM_027106 mRNA. 6985427 -0.65362 0.003265 Kars lysyl-tRNA synthetase (Kars), transcript NM_001130868 variant 1, mRNA. 6764040 -0.65369 8.33E-05 Fcgr3 Fc receptor, IgG, low affinity III (Fcgr3), NM_010188 mRNA. 6957640 -0.6537 0.000394 Dusp16 dual specificity phosphatase 16 (Dusp16), NM_130447 transcript variant A1, mRNA. 6868021 -0.65412 0.001417 Fads1 fatty acid desaturase 1 (Fads1), mRNA. NM_146094 6966425 -0.65417 0.00618 Gpi1 glucose phosphate isomerase 1 (Gpi1), NM_008155 mRNA. 6825638 -0.6548 0.003921 Slc25a37 solute carrier family 25, member 37 NM_026331 (Slc25a37), nuclear gene encoding mitochondrial protein, mRNA. 6889413 -0.65481 0.006577 Rcn1 reticulocalbin 1 (Rcn1), mRNA. NM_009037 6891466 -0.65527 0.00189 Esf1 ESF1, nucleolar pre-rRNA processing NM_001081090 protein, homolog (S. cerevisiae) (Esf1), mRNA. 6819209 -0.65534 0.007264 Ngdn neuroguidin, EIF4E binding protein (Ngdn), NM_026890 mRNA. 6754893 -0.65587 0.009674 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 NM_019993 (Aldh9a1), mRNA. 6774391 -0.65614 0.001588 Hk1 hexokinase 1 (Hk1), nuclear gene NM_010438 encoding mitochondrial protein, transcript variant 2, mRNA. 6992409 -0.65619 0.003569 Nme6 non-metastatic cells 6, protein expressed NM_018757 in (nucleoside-diphosphate kinase) (Nme6), mRNA. 6798281 -0.65621 0.000328 AW555464 expressed sequence AW555464 NM_001024602 (AW555464), mRNA. 6785261 -0.65651 0.006119 9-Sep septin 9 (Sept9), transcript variant 1, NM_001113486 mRNA. 6850763 -0.65657 2.58E-05 Trerf1 transcriptional regulating factor 1 (Trerf1), NM_001097623 transcript variant 1, mRNA. 6854271 -0.65662 3.33E-05 Kremen2 kringle containing transmembrane protein NM_028416 2 (Kremen2), mRNA. 6931377 -0.65752 0.003252 Slc30a9 solute carrier family 30 (zinc transporter), NM_178651 member 9 (Slc30a9), mRNA.

6946554 -0.65761 0.003563 Abcg2 ATP-binding cassette, sub-family G NM_011920 (WHITE), member 2 (Abcg2), mRNA. 6900095 -0.65798 1.34E-05 Dennd2c DENN/MADD domain containing 2C NM_177857 (Dennd2c), mRNA. 6837105 -0.658 0.001991 Csnk1e casein kinase 1, epsilon (Csnk1e), mRNA. NM_013767

6871429 -0.65866 0.000332 Asrgl1 asparaginase like 1 (Asrgl1), mRNA. NM_025610 6942553 -0.65909 0.001908 Gnb2 guanine nucleotide binding protein (G NM_010312 protein), beta 2 (Gnb2), mRNA. 6848146 -0.6594 0.000143 Psmg1 proteasome (prosome, macropain) NM_019537 assembly chaperone 1 (Psmg1), mRNA. 6772482 -0.65941 0.002857 Pex7 peroxisomal biogenesis factor 7 (Pex7), NM_008822 transcript variant 1, mRNA. 6781941 -0.65993 5.4E-05 Myh10 myosin, heavy polypeptide 10, non-muscle NM_175260 (Myh10), mRNA. 6813187 -0.66036 0.00388 Sema4d sema domain, immunoglobulin domain NM_013660 (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (Sema4d), mRNA. 6783029 -0.66044 0.001427 Taf15 TAF15 RNA polymerase II, TATA box NM_027427 binding protein (TBP)-associated factor (Taf15), mRNA. 7020162 -0.66049 0.004168 Gnl3l guanine nucleotide binding protein-like 3 NM_198110 (nucleolar)-like (Gnl3l), transcript variant 1, mRNA. 6756625 -0.66054 0.008548 Mrpl15 mitochondrial ribosomal protein L15 NM_001177658 (Mrpl15), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6970944 -0.66112 0.000112 Cdr2 cerebellar degeneration-related 2 (Cdr2), NM_007672 mRNA. 6926033 -0.66131 0.007195 Tmem57 transmembrane protein 57 (Tmem57), NM_025382 mRNA. 6775298 -0.66144 0.004338 Ppap2c phosphatidic acid phosphatase type 2C NM_015817 (Ppap2c), mRNA. 6933812 -0.66194 0.003243 Tesc tescalcin (Tesc), mRNA. NM_021344 6758325 -0.66224 0.002504 Uxs1 UDP-glucuronate decarboxylase 1 (Uxs1), NM_026430 mRNA. 6813326 -0.66235 0.001486 Nop16 NOP16 nucleolar protein homolog (yeast) NM_178605 (Nop16), mRNA. 6977669 -0.66257 0.000217 Ndufb7 NADH dehydrogenase (ubiquinone) 1 beta NM_025843 subcomplex, 7 (Ndufb7), nuclear gene encoding mitochondrial protein, mRNA.

6782656 -0.66309 0.007599 Flot2 flotillin 2 (Flot2), transcript variant 2, NM_008028 mRNA. 6886073 -0.66328 0.006494 Ndufa8 NADH dehydrogenase (ubiquinone) 1 NM_026703 alpha subcomplex, 8 (Ndufa8), nuclear gene encoding mitochondrial protein, mRNA. 6897577 -0.6633 0.009425 Alg5 asparagine-linked glycosylation 5 homolog NM_025442 (yeast, dolichyl-phosphate beta- glucosyltransferase) (Alg5), mRNA. 6852882 -0.66331 0.000146 Epcam epithelial cell adhesion molecule (Epcam), NM_008532 mRNA. 6867984 -0.66372 0.002949 Tut1 terminal uridylyl transferase 1, U6 snRNA- NM_197993 specific (Tut1), mRNA. 6915619 -0.66424 8.32E-05 Nfia nuclear factor I/A (Nfia), transcript variant NM_010905 2, mRNA. 6925837 -0.66428 0.002626 Ppp1r8 protein phosphatase 1, regulatory NM_146154 (inhibitor) subunit 8 (Ppp1r8), mRNA. 6803780 -0.66515 0.002471 Cinp cyclin-dependent kinase 2 interacting NM_026048 protein (Cinp), mRNA. 6837447 -0.66563 0.000665 Ttll1 tubulin tyrosine ligase-like 1 (Ttll1), mRNA. NM_178869

6992189 -0.66641 0.006234 Vprbp Vpr (HIV-1) binding protein (Vprbp), NM_001015507 mRNA. 6977014 -0.66672 0.001362 Ell elongation factor RNA polymerase II (Ell), NM_007924 mRNA. 6775175 -0.667 0.001704 Pcnt pericentrin (kendrin) (Pcnt), transcript NM_008787 variant 1, mRNA. 6906900 -0.66703 0.002094 Snapin SNAP-associated protein (Snapin), mRNA. NM_133854

6827790 -0.6672 0.003443 Tgds TDP-glucose 4,6-dehydratase (Tgds), NM_029578 mRNA. 6751698 -0.66723 0.007025 2-Sep septin 2 (Sept2), transcript variant 1, NM_001159719 mRNA. 6766240 -0.66795 0.000233 Cited2 Cbp/p300-interacting transactivator, with NM_010828 Glu/Asp-rich carboxy-terminal domain, 2 (Cited2), mRNA. 6787283 -0.66806 0.008051 Rars arginyl-tRNA synthetase (Rars), mRNA. NM_025936 6840199 -0.66808 0.00549 Lpp LIM domain containing preferred BC005613 translocation partner in lipoma, mRNA (cDNA clone IMAGE:3710749). 6994830 -0.66811 0.002689 Gramd1b GRAM domain containing 1B (Gramd1b), NM_172768 mRNA. 6966494 -0.66819 0.008208 Nudt19 nudix (nucleoside diphosphate linked NM_033080 moiety X)-type motif 19 (Nudt19), nuclear gene encoding mitochondrial protein, mRNA. 6954529 -0.66821 0.000359 Rpia ribose 5-phosphate isomerase A (Rpia), NM_009075 mRNA. 6769447 -0.66823 0.007577 Polr3b polymerase (RNA) III (DNA directed) NM_027423 polypeptide B (Polr3b), mRNA. 6851734 -0.6688 0.007424 Ppp4r1 protein phosphatase 4, regulatory subunit 1 NM_146081 (Ppp4r1), transcript variant 1, mRNA.

7015449 -0.66917 0.005534 Wdr13 WD repeat domain 13 (Wdr13), transcript NM_026137 variant 1, mRNA. 6919012 -0.66963 0.00801 Acot7 acyl-CoA thioesterase 7 (Acot7), transcript NM_001146057 variant 1, mRNA. 6791151 -0.67016 0.005122 Kpnb1 karyopherin (importin) beta 1 (Kpnb1), NM_008379 mRNA. 6855057 -0.67033 0.003008 Stk19 serine/threonine kinase 19 (Stk19), mRNA. NM_019442

6973624 -0.67162 0.007917 Trim28 tripartite motif-containing 28 (Trim28), NM_011588 mRNA. 6860121 -0.67174 0.005321 Slc35a4 solute carrier family 35, member A4 NM_026404 (Slc35a4), transcript variant 1, mRNA. 6785750 -0.67231 0.002398 Pold2 polymerase (DNA directed), delta 2, NM_008894 regulatory subunit (Pold2), mRNA. 6955037 -0.67306 0.000295 Stambp STAM binding protein (Stambp), mRNA. NM_024239 6966490 -0.67359 0.00035 C230052I12Ri RIKEN cDNA C230052I12 gene NM_178643 k (C230052I12Rik), mRNA. 6957330 -0.67405 3.14E-05 Tulp3 tubby-like protein 3 (Tulp3), mRNA. NM_011657 6815797 -0.67418 0.002294 Kif2a kinesin family member 2A (Kif2a), NM_008442 transcript variant 1, mRNA. 6791175 -0.67501 0.004382 Npepps aminopeptidase puromycin sensitive NM_008942 (Npepps), mRNA. 6843335 -0.67555 0.0012 Cbr1 carbonyl reductase 1 (Cbr1), mRNA. NM_007620 6996440 -0.67635 0.001281 Rab8b RAB8B, member RAS oncogene family NM_173413 (Rab8b), mRNA. 6840860 -0.67647 0.003329 Tmem39a transmembrane protein 39a (Tmem39a), NM_026407 mRNA. 6796707 -0.67741 0.000599 Ttll5 tubulin tyrosine ligase-like family, member NM_001081423 5 (Ttll5), mRNA. 6901747 -0.67824 0.004167 Adh5 alcohol dehydrogenase 5 (class III), chi NM_007410 polypeptide (Adh5), mRNA. 6977032 -0.67837 0.001168 Rab3a RAB3A, member RAS oncogene family NM_001166399 (Rab3a), transcript variant 1, mRNA. 6813110 -0.67852 0.000452 Cenpp centromere protein P (Cenpp), mRNA. NM_025495 6843943 -0.67859 0.004681 Zc3h7a zinc finger CCCH type containing 7 A NM_145931 (Zc3h7a), transcript variant 1, mRNA. 6886356 -0.67875 0.000176 Zeb2 zinc finger E-box binding homeobox 2 NM_015753 (Zeb2), transcript variant 2, mRNA. 6988624 -0.67913 0.002144 Dpagt1 dolichyl-phosphate (UDP-N- NM_007875 acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) (Dpagt1), mRNA. 6753135 -0.67947 0.009037 Rbbp5 retinoblastoma binding protein 5 (Rbbp5), NM_172517 mRNA. 6775460 -0.67969 0.006565 Fzr1 fizzy/cell division cycle 20 related 1 NM_019757 (Drosophila) (Fzr1), mRNA. 6836979 -0.6806 0.006274 Txn2 thioredoxin 2 (Txn2), nuclear gene NM_019913 encoding mitochondrial protein, mRNA. 6817956 -0.68077 0.00111 Nek4 NIMA (never in mitosis gene a)-related NM_011849 expressed kinase 4 (Nek4), mRNA. 6926076 -0.68094 0.002277 Srrm1 serine/arginine repetitive matrix 1 (Srrm1), NM_016799 transcript variant 1, mRNA. 6855829 -0.68094 0.001084 Nfya nuclear transcription factor-Y alpha (Nfya), NM_001110832 transcript variant 1, mRNA. 6775411 -0.68122 1.75E-05 Lmnb2 lamin B2 (Lmnb2), mRNA. NM_010722 6938698 -0.68179 0.003784 Rfc1 replication factor C (activator 1) 1 (Rfc1), NM_011258 mRNA. 6839956 -0.68214 0.004633 Eif4g1 eukaryotic translation initiation factor 4, NM_145941 gamma 1 (Eif4g1), transcript variant 1, mRNA. 6995121 -0.68222 0.003921 Arcn1 archain 1 (Arcn1), mRNA. NM_145985 6854369 -0.68239 0.004125 Mlst8 MTOR associated protein, LST8 homolog NM_019988 (S. cerevisiae) (Mlst8), mRNA. 6790508 -0.68278 0.00342 Tmem49 transmembrane protein 49 (Tmem49), NM_029478 mRNA. 6838134 -0.68327 0.003106 Pus7l pseudouridylate synthase 7 homolog (S. NM_172437 cerevisiae)-like (Pus7l), mRNA. 6792848 -0.68349 0.000627 1110031I02Rik RIKEN cDNA 1110031I02 gene NM_025402 (1110031I02Rik), mRNA. 6789444 -0.68406 0.000864 Pfn1 profilin 1 (Pfn1), mRNA. NM_011072 6935701 -0.68485 0.000625 Alox5ap arachidonate 5-lipoxygenase activating NM_009663 protein (Alox5ap), mRNA. 6840837 -0.68486 0.009242 Cox17 cytochrome c oxidase, subunit XVII NM_001017429 assembly protein homolog (yeast) (Cox17), mRNA. 6861747 -0.685 0.002419 Cep192 centrosomal protein 192 (Cep192), mRNA. NM_027556 6919199 -0.68516 0.009073 Ube2j2 ubiquitin-conjugating enzyme E2, J2 NM_021402 homolog (yeast) (Ube2j2), transcript variant 1, mRNA. 6929713 -0.68516 0.000512 Mrpl33 mitochondrial ribosomal protein L33 NM_025796 (Mrpl33), nuclear gene encoding mitochondrial protein, mRNA. 6832532 -0.68548 0.00471 Pim3 proviral integration site 3 (Pim3), mRNA. NM_145478 6880219 -0.686 4.68E-05 BC052040 cDNA sequence BC052040 (BC052040), NM_001145898 transcript variant 1, mRNA. 6862126 -0.68613 0.00522 BC031181 cDNA sequence BC031181, mRNA (cDNA BC016084 clone MGC:27590 IMAGE:4501468), complete cds. 6922244 -0.68632 0.000918 Pole3 polymerase (DNA directed), epsilon 3 (p17 NM_021498 subunit) (Pole3), mRNA. 6986604 -0.68675 0.001762 8430410K20Ri RIKEN cDNA 8430410K20 gene, mRNA BC014729 k (cDNA clone MGC:25466 IMAGE:4461077), complete cds. 6942606 -0.68686 0.001038 Taf6 TAF6 RNA polymerase II, TATA box NM_009315 binding protein (TBP)-associated factor (Taf6), mRNA. 6952426 -0.68704 0.004622 Tmem209 transmembrane protein 209 (Tmem209), NM_178625 mRNA. 6946802 -0.68733 0.000232 Serbp1 serpine1 mRNA binding protein 1 (Serbp1), NM_025814 transcript variant 1, mRNA. 6867615 -0.68759 0.005004 Unc93b1 unc-93 homolog B1 (C. elegans) NM_019449 (Unc93b1), transcript variant 1, mRNA. 6820372 -0.68862 0.007259 Nufip1 nuclear fragile X mental retardation protein NM_013745 interacting protein 1 (Nufip1), mRNA.

6867593 -0.68867 0.000212 1810055G02Ri RIKEN cDNA 1810055G02 gene, mRNA BC019471 k (cDNA clone MGC:28461 IMAGE:4161022), complete cds. 6875825 -0.68876 0.00463 Surf2 surfeit gene 2 (Surf2), mRNA. NM_013678 6902799 -0.68896 0.000638 Lrrc40 leucine rich repeat containing 40 (Lrrc40), NM_024194 mRNA. 5027255 -0.68921 0.005966 --- AFFX-r2-Bs-thr-5_s_st, polya_spike --- 7020716 -0.69014 0.005632 Mospd2 motile sperm domain containing 2 NM_029730 (Mospd2), mRNA. 6896852 -0.69017 0.000156 Bbs12 Bardet-Biedl syndrome 12 (human) NM_001008502 (Bbs12), mRNA. 6870172 -0.69035 0.007758 6330577E15Ri RIKEN cDNA 6330577E15 gene NM_026377 k (6330577E15Rik), mRNA. 6969735 -0.69041 0.007586 Rps3 ribosomal protein S3 (Rps3), mRNA. NM_012052 6892852 -0.69068 0.002716 Ada adenosine deaminase (Ada), mRNA. NM_007398 6935524 -0.69079 0.002446 Cdk8 cyclin-dependent kinase 8 (Cdk8), mRNA. NM_153599

6849612 -0.69092 0.009323 BC004004 cDNA sequence BC004004 (BC004004), NM_030561 mRNA. 6985330 -0.69095 0.009575 Sf3b3 splicing factor 3b, subunit 3 (Sf3b3), NM_133953 mRNA. 6854694 -0.69099 0.007387 Mtch1 mitochondrial carrier homolog 1 (C. NM_019880 elegans) (Mtch1), nuclear gene encoding mitochondrial protein, mRNA. 6940883 -0.69117 0.00351 Tmed5 transmembrane emp24 protein transport NM_028876 domain containing 5 (Tmed5), mRNA. 6907652 -0.69133 0.000348 Slc22a15 solute carrier family 22 (organic NM_001039371 anion/cation transporter), member 15 (Slc22a15), mRNA. 6886045 -0.69134 0.002395 Ggta1 glycoprotein galactosyltransferase alpha 1, NM_010283 3 (Ggta1), transcript variant 1, mRNA. 6907202 -0.69155 9.82E-06 Adamtsl4 ADAMTS-like 4 (Adamtsl4), mRNA. NM_144899 6972110 -0.69224 0.00147 Tubgcp2 tubulin, gamma complex associated NM_133755 protein 2 (Tubgcp2), mRNA. 6887450 -0.69308 0.002394 Stk39 serine/threonine kinase 39, STE20/SPS1 NM_016866 homolog (yeast) (Stk39), mRNA.

6771954 -0.69328 0.00427 Pcmt1 protein-L-isoaspartate (D-aspartate) O- NM_008786 methyltransferase 1 (Pcmt1), mRNA. 6749923 -0.6936 0.003776 Eef1b2 eukaryotic translation elongation factor 1 NM_018796 beta 2 (Eef1b2), mRNA. 6817217 -0.69364 0.003874 Thrb thyroid hormone receptor beta (Thrb), NM_001113417 transcript variant 1, mRNA. 6813470 -0.69382 0.007231 H2afy H2A histone family, member Y (H2afy), NM_012015 transcript variant 1, mRNA. 6782273 -0.69397 0.009131 Atp2a3 ATPase, Ca++ transporting, ubiquitous NM_016745 (Atp2a3), transcript variant 2, mRNA. 6778278 -0.69452 0.008219 Eif4enif1 eukaryotic translation initiation factor 4E NM_023743 nuclear import factor 1 (Eif4enif1), transcript variant 1, mRNA. 4935275 -0.69464 0.007291 --- AFFX-r2-Bs-phe-M_st, polya_spike --- 6938679 -0.69516 9.38E-05 Tlr6 toll-like receptor 6 (Tlr6), mRNA. NM_011604 6837096 -0.69567 8.86E-06 Pla2g6 phospholipase A2, group VI (Pla2g6), NM_016915 mRNA. 6937334 -0.69589 0.004093 Nop14 NOP14 nucleolar protein homolog (yeast) NM_029278 (Nop14), mRNA. 6790318 -0.6962 0.001154 Tada2a transcriptional adaptor 2A (Tada2a), NM_172562 mRNA. 6945526 -0.69627 0.001808 Trim24 tripartite motif-containing 24 (Trim24), NM_145076 mRNA. 6962773 -0.69635 0.003258 Clns1a chloride channel, nucleotide-sensitive, 1A NM_023671 (Clns1a), mRNA. 6968647 -0.69648 0.002703 Mrpl46 mitochondrial ribosomal protein L46 NM_023331 (Mrpl46), nuclear gene encoding mitochondrial protein, mRNA. 6765222 -0.69678 0.001827 Nenf neuron derived neurotrophic factor (Nenf), NM_025424 mRNA. 6762413 -0.69717 0.004303 Rnpep arginyl aminopeptidase (aminopeptidase B) NM_145417 (Rnpep), transcript variant 1, mRNA. 6769617 -0.69763 0.007597 Ccdc53 coiled-coil domain containing 53 (Ccdc53), NM_026070 transcript variant 1, mRNA. 6843207 -0.69765 0.003074 Mrps6 mitochondrial ribosomal protein S6 NM_080456 (Mrps6), nuclear gene encoding mitochondrial protein, mRNA. 6844081 -0.698 0.001595 --- LOC622757 gene, mRNA (cDNA clone BC006659 IMAGE:3501077), **** WARNING: chimeric clone ****. 6990774 -0.69845 9.52E-06 Myo6 myosin VI (Myo6), mRNA. NM_001039546 6870891 -0.69883 0.003063 Fam45a family with sequence similarity 45, member NM_026437 A (Fam45a), transcript variant 1, mRNA.

6772476 -0.69896 0.001864 Slc35d3 solute carrier family 35, member D3 NM_029529 (Slc35d3), mRNA. 6782136 -0.69911 0.000911 Mink1 misshapen-like kinase 1 (zebrafish) NM_001045959 (Mink1), transcript variant 3, mRNA. 6866635 -0.69921 0.003467 Elac1 elaC homolog 1 (E. coli) (Elac1), mRNA. NM_053255 6876109 -0.69935 0.00027 Ncs1 neuronal calcium sensor 1 (Ncs1), mRNA. NM_019681

6843643 -0.70011 0.002845 Tcfap4 transcription factor AP4 (Tcfap4), mRNA. NM_031182

7015425 -0.70016 5.62E-06 Hdac6 histone deacetylase 6 (Hdac6), transcript NM_010413 variant 1, mRNA. 6841862 -0.70043 2.07E-05 Cpox coproporphyrinogen oxidase (Cpox), NM_007757 mRNA. 6782655 -0.70118 0.001189 Dhrs13 dehydrogenase/reductase (SDR family) NM_183286 member 13 (Dhrs13), mRNA. 6768901 -0.70152 0.001931 Zfp280b zinc finger protein 280B (Zfp280b), mRNA. NM_177475

6792742 -0.70167 0.009138 Slc38a10 solute carrier family 38, member 10 NM_024249 (Slc38a10), transcript variant 1, mRNA. 6856292 -0.70173 0.005908 Gpr108 G protein-coupled receptor 108 (Gpr108), NM_030084 mRNA. 6921000 -0.70211 0.004398 Bag1 BCL2-associated athanogene 1 (Bag1), NM_009736 transcript variant 1, mRNA. 6985925 -0.70225 0.000178 Mvd mevalonate (diphospho) decarboxylase NR_028354 (Mvd), transcript variant 2, non-coding RNA. 6814330 -0.70318 0.000233 Ndufs6 NADH dehydrogenase (ubiquinone) Fe-S NR_033306 protein 6 (Ndufs6), transcript variant 2, non- coding RNA. 6867972 -0.70334 0.004547 Ubxn1 UBX domain protein 1 (Ubxn1), mRNA. NM_146093 6917489 -0.70362 0.003501 Taf12 TAF12 RNA polymerase II, TATA box NM_025579 binding protein (TBP)-associated factor (Taf12), mRNA. 6998606 -0.70365 0.009712 Mapkapk3 mitogen-activated protein kinase-activated NM_178907 protein kinase 3 (Mapkapk3), mRNA.

6977251 -0.70376 0.000227 Hmgxb4 HMG box domain containing 4 (Hmgxb4), NM_178017 mRNA. 6965130 -0.70479 0.002062 Ric8 resistance to inhibitors of cholinesterase 8 NM_053194 homolog (C. elegans) (Ric8), mRNA. 6854389 -0.70509 0.000742 Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta NM_026684 subcomplex, 10 (Ndufb10), nuclear gene encoding mitochondrial protein, mRNA.

6778315 -0.70514 0.003218 Morc2a microrchidia 2A (Morc2a), transcript variant NM_001159288 1, mRNA. 7014048 -0.70538 9.3E-05 Zcchc18 zinc finger, CCHC domain containing 18 NM_001035510 (Zcchc18), transcript variant 1, mRNA. 6954988 -0.70557 0.008075 Sema4f sema domain, immunoglobulin domain NM_011350 (Ig), TM domain, and short cytoplasmic domain (Sema4f), transcript variant 1, mRNA. 6899104 -0.70573 0.005127 Cct3 chaperonin containing Tcp1, subunit 3 NM_009836 (gamma) (Cct3), mRNA. 6768150 -0.70706 0.004289 Ascc1 activating signal cointegrator 1 complex NM_026937 subunit 1 (Ascc1), mRNA. 6838979 -0.70715 0.009579 Zfp263 zinc finger protein 263 (Zfp263), mRNA. NM_148924 6946031 -0.70758 0.008347 Gimap7 GTPase, IMAP family member 7 (Gimap7), NM_146167 mRNA. 6907217 -0.70787 0.000849 Vps45 vacuolar protein sorting 45 (yeast) (Vps45), NM_013841 mRNA. 6784605 -0.70811 0.001766 Ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_028074 42 (Ddx42), mRNA. 6989922 -0.70826 0.005045 Clpx caseinolytic peptidase X (E.coli) (Clpx), NM_011802 transcript variant 1, mRNA. 6976498 -0.70853 0.002983 Nek1 NIMA (never in mitosis gene a)-related NM_175089 expressed kinase 1 (Nek1), mRNA. 6831852 -0.70877 0.004842 Triobp TRIO and F-actin binding protein (Triobp), NM_001039156 transcript variant 3, mRNA. 6869885 -0.709 0.002745 Entpd7 ectonucleoside triphosphate NM_053103 diphosphohydrolase 7 (Entpd7), mRNA. 6839746 -0.70906 0.005873 Lztr1 leucine-zipper-like transcriptional regulator, NM_025808 1 (Lztr1), mRNA. 6990842 -0.70912 2.44E-05 Mei4 meiosis-specific, MEI4 homolog (S. NM_175213 cerevisiae) (Mei4), mRNA. 6836842 -0.70918 0.000368 Nfkbil2 nuclear factor of kappa light polypeptide NM_183091 gene enhancer in B-cells inhibitor-like 2 (Nfkbil2), mRNA. 6916502 -0.70932 0.002188 4732418C07Ri RIKEN cDNA 4732418C07 gene, mRNA BC059213 k (cDNA clone MGC:66557 IMAGE:6408754), complete cds. 6757796 -0.70964 0.001757 Ccdc115 coiled-coil domain containing 115 NM_027159 (Ccdc115), mRNA. 6903157 -0.71004 0.000299 Pag1 phosphoprotein associated with NM_001195031 glycosphingolipid microdomains 1 (Pag1), transcript variant A, mRNA. 6983898 -0.71041 0.007854 Asna1 arsA arsenite transporter, ATP-binding, NM_019652 homolog 1 (bacterial) (Asna1), mRNA. 6955514 -0.71044 0.00982 Nup210 nucleoporin 210 (Nup210), mRNA. NM_018815 6889301 -0.71082 0.001679 Nat10 N-acetyltransferase 10 (Nat10), mRNA. NM_153126 6775149 -0.71123 8.09E-05 Gstt3 glutathione S-transferase, theta 3 (Gstt3), NM_133994 mRNA. 6868193 -0.71362 0.007609 Lpxn leupaxin (Lpxn), mRNA. NM_134152 6992887 -0.7139 0.003499 Exog endo/exonuclease (5'-3'), endonuclease G- NM_001172136 like (Exog), transcript variant 1, mRNA.

6983145 -0.7142 0.006859 Gatad2a GATA zinc finger domain containing 2A NM_145596 (Gatad2a), transcript variant 1, mRNA. 6904074 -0.71495 0.005791 Mrpl47 mitochondrial ribosomal protein L47 NM_029017 (Mrpl47), nuclear gene encoding mitochondrial protein, mRNA. 6846571 -0.71626 2.89E-05 Crybg3 beta-gamma crystallin domain containing 3 NM_174848 (Crybg3), mRNA. 6854400 -0.71683 0.006204 Mapk8ip3 mitogen-activated protein kinase 8 NM_013931 interacting protein 3 (Mapk8ip3), transcript variant 1, mRNA. 6850090 -0.71731 0.000115 Lsm2 LSM2 homolog, U6 small nuclear RNA NM_030597 associated (S. cerevisiae) (Lsm2), transcript variant 1, mRNA. 6833151 -0.71741 0.000136 Spats2 spermatogenesis associated, serine-rich 2 NM_139140 (Spats2), mRNA. 6870104 -0.71745 0.000709 As3mt arsenic (+3 oxidation state) NM_020577 methyltransferase (As3mt), mRNA. 6893173 -0.71754 0.003236 Spata2 spermatogenesis associated 2 (Spata2), NM_170756 mRNA. 6899667 -0.71759 0.000487 Fam63a family with sequence similarity 63, member NM_199475 A (Fam63a), transcript variant 1, mRNA.

6791800 -0.71853 0.003031 Cdc27 cell division cycle 27 homolog (S. NM_145436 cerevisiae) (Cdc27), mRNA. 6909516 -0.71862 0.001744 Gstcd glutathione S-transferase, C-terminal NM_026231 domain containing (Gstcd), mRNA. 6941672 -0.71869 0.000293 Trafd1 TRAF type zinc finger domain containing 1 NM_001163470 (Trafd1), transcript variant 1, mRNA. 6955215 -0.71877 0.00232 Pcbp1 poly(rC) binding protein 1 (Pcbp1), mRNA. NM_011865

6887901 -0.71912 0.006125 Lnp limb and neural patterns (Lnp), transcript NM_001110209 variant 2, mRNA. 6907615 -0.7193 0.000135 Ttf2 transcription termination factor, RNA NM_001013026 polymerase II (Ttf2), mRNA. 6925156 -0.7197 0.00104 Ppie peptidylprolyl isomerase E (cyclophilin E) NM_019489 (Ppie), mRNA. 6855670 -0.71986 0.00252 Mad2l1bp MAD2L1 binding protein (Mad2l1bp), NM_025649 mRNA. 6788672 -0.72011 0.00024 Snap47 synaptosomal-associated protein, 47 NM_144521 (Snap47), mRNA. 6973527 -0.72029 3.35E-05 Lair1 leukocyte-associated Ig-like receptor 1 NM_001113474 (Lair1), transcript variant a, mRNA. 6921029 -0.72057 2.39E-05 Kif24 kinesin family member 24 (Kif24), mRNA. NM_024241

6891675 -0.72059 0.000962 Snx5 sorting nexin 5 (Snx5), mRNA. NM_024225 6819957 -0.72103 0.002269 Kctd9 potassium channel tetramerisation domain NM_001111028 containing 9 (Kctd9), transcript variant 1, mRNA. 6837445 -0.7213 0.002223 Pacsin2 protein kinase C and casein kinase NM_011862 substrate in neurons 2 (Pacsin2), transcript variant 1, mRNA. 6918310 -0.72164 0.000756 Pramef8 PRAME family member 8 (Pramef8), NM_172877 mRNA. 6786463 -0.7224 0.001535 Actr2 ARP2 actin-related protein 2 homolog NM_146243 (yeast) (Actr2), mRNA. 5262043 -0.72251 0.002031 --- AFFX-r2-Bs-thr-M_s_st, polya_spike --- 6863158 -0.72269 0.004912 Kif5b kinesin family member 5B (Kif5b), mRNA. NM_008448

6875865 -0.72282 0.007026 Wdr5 WD repeat domain 5 (Wdr5), mRNA. NM_080848 6775159 -0.72309 0.006433 Smarcb1 SWI/SNF related, matrix associated, actin NM_011418 dependent regulator of chromatin, subfamily b, member 1 (Smarcb1), transcript variant 1, mRNA. 6778998 -0.72411 0.003937 C1d C1D nuclear receptor co-repressor (C1d), NM_020558 mRNA. 6781560 -0.72443 0.000305 Adora2b adenosine A2b receptor (Adora2b), mRNA. NM_007413

6778383 -0.72477 0.001343 Gatsl3 GATS protein-like 3 (Gatsl3), mRNA. NM_028022 6987343 -0.72534 0.000254 Ppan peter pan homolog (Drosophila) (Ppan), NM_145610 mRNA. 7018249 -0.72682 0.001716 Eif2s3x eukaryotic translation initiation factor 2, NM_012010 subunit 3, structural gene X-linked (Eif2s3x), mRNA. 6970125 -0.72703 0.003184 Fam160a2 family with sequence similarity 160, NM_199009 member A2 (Fam160a2), mRNA. 6831162 -0.72727 3.54E-06 Tg thyroglobulin (Tg), mRNA. NM_009375 6835222 -0.72734 0.00876 Lrp12 low density lipoprotein-related protein 12 NM_172814 (Lrp12), mRNA. 6982153 -0.72766 0.004153 Ankrd37 ankyrin repeat domain 37 (Ankrd37), NM_001039562 mRNA. 6775888 -0.72778 0.002978 Scyl2 SCY1-like 2 (S. cerevisiae) (Scyl2), mRNA. NM_198021 6909555 -0.72787 0.000461 Tet2 tet oncogene family member 2 (Tet2), NM_001040400 mRNA. 6778595 -0.72835 5.1E-07 Ramp3 receptor (calcitonin) activity modifying NM_019511 protein 3 (Ramp3), mRNA. 6929152 -0.72844 0.005389 Psmc2 proteasome (prosome, macropain) 26S NM_011188 subunit, ATPase 2 (Psmc2), mRNA. 6924691 -0.72866 0.005871 Cmpk1 cytidine monophosphate (UMP-CMP) NM_025647 kinase 1 (Cmpk1), mRNA. 6759326 -0.72868 0.00244 Fam119a family with sequence similarity 119, BC026952 member A, mRNA (cDNA clone MGC:30396 IMAGE:4483032), complete cds. 6864678 -0.72898 0.000519 Pfdn1 prefoldin 1 (Pfdn1), mRNA. NM_026027 6988102 -0.72916 0.003087 Rpusd4 RNA pseudouridylate synthase domain NM_028040 containing 4 (Rpusd4), mRNA. 6783337 -0.7307 0.009563 Bzrap1 benzodiazapine receptor associated NM_172449 protein 1 (Bzrap1), mRNA. 6947679 -0.73074 0.001659 Gfpt1 glutamine fructose-6-phosphate NM_013528 transaminase 1 (Gfpt1), mRNA. 6881267 -0.73077 0.002187 Smox spermine oxidase (Smox), transcript NM_001177833 variant 1, mRNA. 6960436 -0.73124 0.005328 Nomo1 nodal modulator 1 (Nomo1), mRNA. NM_153057 6899092 -0.73128 0.006067 Iqgap3 IQ motif containing GTPase activating NM_001033484 protein 3 (Iqgap3), mRNA. 6918720 -0.73194 0.007317 Srm spermidine synthase (Srm), mRNA. NM_009272 6850678 -0.73208 0.00146 Mrps18a mitochondrial ribosomal protein S18A NM_026768 (Mrps18a), nuclear gene encoding mitochondrial protein, mRNA. 6988672 -0.73286 0.000673 Ift46 intraflagellar transport 46 homolog NM_023831 (Chlamydomonas) (Ift46), mRNA. 6966302 -0.73323 0.002444 Cox6b1 cytochrome c oxidase, subunit VIb NM_025628 polypeptide 1 (Cox6b1), nuclear gene encoding mitochondrial protein, mRNA. 6784526 -0.73329 0.002796 Myl4 myosin, light polypeptide 4 (Myl4), mRNA. NM_010858

6886017 -0.73356 7.1E-05 Phf19 PHD finger protein 19 (Phf19), mRNA. NM_028716 6850421 -0.73388 0.005017 Mut methylmalonyl-Coenzyme A mutase (Mut), NM_008650 nuclear gene encoding mitochondrial protein, mRNA. 6956748 -0.734 0.00087 Plxnd1 plexin D1 (Plxnd1), mRNA. NM_026376 6774021 -0.73423 0.000666 9530009G21Ri adult male urinary bladder cDNA, RIKEN AK079179 k full-length enriched library, clone:9530009G21 product:hypothetical protein, full insert sequence. 6750552 -0.7344 0.009834 Rqcd1 rcd1 (required for cell differentiation) NM_021383 homolog 1 (S. pombe) (Rqcd1), mRNA. 6933073 -0.73465 1.01E-05 Pkd2 polycystic kidney disease 2 (Pkd2), mRNA. NM_008861

6883125 -0.73498 0.001767 Mmp9 matrix metallopeptidase 9 (Mmp9), mRNA. NM_013599

6966308 -0.73557 0.003555 Tmem147 transmembrane protein 147 (Tmem147), NM_027215 mRNA. 6841097 -0.73588 0.006137 Naa50 N(alpha)-acetyltransferase 50, NatE NM_028108 catalytic subunit (Naa50), mRNA. 6963418 -0.73613 0.000698 Wee1 WEE 1 homolog 1 (S. pombe) (Wee1), NM_009516 mRNA. 6856210 -0.7363 0.007718 Dpp9 dipeptidylpeptidase 9 (Dpp9), mRNA. NM_172624 6983793 -0.73658 0.003702 Pkn1 protein kinase N1 (Pkn1), mRNA. NM_177262 6779185 -0.73672 0.003472 Spred2 sprouty-related, EVH1 domain containing BC040462 2, mRNA (cDNA clone IMAGE:4241850).

6934401 -0.7368 0.000211 Aacs acetoacetyl-CoA synthetase (Aacs), NM_030210 mRNA. 6779832 -0.73703 0.002616 Snrnp25 small nuclear ribonucleoprotein 25 NM_030093 (U11/U12) (Snrnp25), mRNA. 6929960 -0.73715 0.00417 Grpel1 GrpE-like 1, mitochondrial (Grpel1), NM_024478 nuclear gene encoding mitochondrial protein, mRNA. 6796164 -0.73719 0.003408 Mthfd1 methylenetetrahydrofolate dehydrogenase NM_138745 (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase (Mthfd1), mRNA. 6785148 -0.73793 7.82E-05 Mrps7 mitchondrial ribosomal protein S7 (Mrps7), NM_025305 mRNA. 6885501 -0.73838 0.001489 Surf6 surfeit gene 6 (Surf6), mRNA. NM_009298 6755197 -0.73852 0.006684 Cd48 CD48 antigen (Cd48), mRNA. NM_007649 6785321 -0.73871 0.002599 Pgs1 phosphatidylglycerophosphate synthase 1 NM_133757 (Pgs1), mRNA. 6963011 -0.73871 0.000112 Clpb ClpB caseinolytic peptidase B homolog (E. NM_009191 coli) (Clpb), mRNA. 6947553 -0.73871 0.004772 Smyd5 SET and MYND domain containing 5 NM_144918 (Smyd5), mRNA. 6858892 -0.739 0.008128 Riok3 RIO kinase 3 (yeast) (Riok3), mRNA. NM_024182 6833919 -0.73904 0.00067 Skp2 S-phase kinase-associated protein 2 (p45) NM_145468 (Skp2), transcript variant 2, mRNA.

6933037 -0.73954 0.002409 Nudt9 nudix (nucleoside diphosphate linked NM_028794 moiety X)-type motif 9 (Nudt9), mRNA. 6772232 -0.73991 1.89E-06 Aig1 androgen-induced 1 (Aig1), mRNA. NM_025446 6935910 -0.74022 0.007443 Ankib1 ankyrin repeat and IBR domain containing NM_001003909 1 (Ankib1), mRNA. 6950334 -0.74065 0.003309 Etv6 ets variant gene 6 (TEL oncogene) (Etv6), NM_007961 mRNA. 6771538 -0.74075 0.008767 Cdk4 cyclin-dependent kinase 4 (Cdk4), mRNA. NM_009870

6969028 -0.74102 4.86E-05 Fah fumarylacetoacetate hydrolase (Fah), NM_010176 mRNA. 6822173 -0.74133 0.000268 Rap2a RAS related protein 2a (Rap2a), mRNA. NM_029519 6946277 -0.74158 0.00508 Tax1bp1 Tax1 (human T-cell leukemia virus type I) NM_025816 binding protein 1 (Tax1bp1), mRNA. 6836849 -0.74182 8.08E-07 Recql4 RecQ protein-like 4 (Recql4), mRNA. NM_058214 6934258 -0.74242 0.000879 Ccdc62 coiled-coil domain containing 62 (Ccdc62), NM_001134767 mRNA. 6837785 -0.74268 6.31E-05 Mapk11 mitogen-activated protein kinase 11 NM_011161 (Mapk11), mRNA. 6987137 -0.74279 0.000129 BC017612 cDNA sequence BC017612 (BC017612), NM_133214 mRNA. 6840677 -0.74352 0.000174 Ccdc14 coiled-coil domain containing 14 (Ccdc14), NM_172824 mRNA. 6916148 -0.74392 0.001972 0610037L13Ri RIKEN cDNA 0610037L13 gene, mRNA BC019215 k (cDNA clone MGC:29264 IMAGE:5065090), complete cds. 6813094 -0.74416 0.001397 Susd3 sushi domain containing 3 (Susd3), mRNA. NM_025491

6792456 -0.74517 0.006322 Slc25a19 solute carrier family 25 (mitochondrial NM_026071 thiamine pyrophosphate carrier), member 19 (Slc25a19), nuclear gene encoding mitochondrial protein, mRNA. 6842085 -0.74553 0.001398 Cggbp1 CGG triplet repeat binding protein 1 NM_178647 (Cggbp1), mRNA. 6972471 -0.74607 0.000358 Fadd Fas (TNFRSF6)-associated via death NM_010175 domain (Fadd), mRNA. 6890068 -0.74662 0.00045 Rasgrp1 RAS guanyl releasing protein 1 (Rasgrp1), NM_011246 mRNA. 6815479 -0.74731 0.004438 Ptcd2 pentatricopeptide repeat domain 2 (Ptcd2), NM_026873 mRNA. 6780725 -0.74775 0.006254 Mgat1 mannoside acetylglucosaminyltransferase NM_001110148 1 (Mgat1), transcript variant 1, mRNA.

6843198 -0.74779 2.6E-06 Itsn1 intersectin 1 (SH3 domain protein 1A) NM_010587 (Itsn1), transcript variant 1, mRNA. 6966189 -0.74818 0.000985 Spred3 sprouty-related, EVH1 domain containing 3 NM_182927 (Spred3), mRNA. 7019547 -0.74862 0.002255 Zmat1 zinc finger, matrin type 1 (Zmat1), mRNA. NM_175446

6879016 -0.74869 0.00273 Psmc3 proteasome (prosome, macropain) 26S NM_008948 subunit, ATPase 3 (Psmc3), mRNA. 6957756 -0.74869 0.00071 Wbp11 WW domain binding protein 11 (Wbp11), NM_021714 mRNA. 6824743 -0.74881 2.19E-06 Jub ajuba (Jub), mRNA. NM_010590 6950558 -0.74945 0.007698 Dera 2-deoxyribose-5-phosphate aldolase NM_172733 homolog (C. elegans) (Dera), mRNA. 6818696 -0.74947 0.004144 Lgals3 lectin, galactose binding, soluble 3 NM_001145953 (Lgals3), transcript variant 1, mRNA. 6878000 -0.74951 0.005779 Dync1i2 dynein cytoplasmic 1 intermediate chain 2 NM_010064 (Dync1i2), mRNA. 6790046 -0.74952 0.000157 Evi2b ecotropic viral integration site 2b (Evi2b), NM_146023 transcript variant 2, mRNA. 6791493 -0.74956 0.000138 Aarsd1 alanyl-tRNA synthetase domain containing NM_144829 1 (Aarsd1), mRNA. 6775206 -0.74965 2.72E-05 Adarb1 adenosine deaminase, RNA-specific, B1 NR_004429 (Adarb1), transcript variant 3, non-coding RNA. 6824835 -0.7498 0.008584 Tinf2 Terf1 (TRF1)-interacting nuclear factor 2 NM_145705 (Tinf2), mRNA. 6825494 -0.7502 0.005677 Dpysl2 dihydropyrimidinase-like 2 (Dpysl2), NM_009955 mRNA. 6877080 -0.75023 0.008108 Rif1 Rap1 interacting factor 1 homolog (yeast) NM_175238 (Rif1), mRNA. 6823460 -0.75031 0.007097 Pde12 phosphodiesterase 12 (Pde12), mRNA. NM_178668 6947555 -0.75044 0.008745 Cct7 chaperonin containing Tcp1, subunit 7 NM_007638 (eta) (Cct7), mRNA. 6935613 -0.75058 0.003227 Pomp proteasome maturation protein (Pomp), NM_025624 mRNA. 6876028 -0.75059 0.003524 Odf2 outer dense fiber of sperm tails 2 (Odf2), NM_001113213 transcript variant 1, mRNA. 6907162 -0.75079 6.99E-05 Anxa9 annexin A9 (Anxa9), transcript variant 1, NM_001085383 mRNA. 6992172 -0.7513 0.003285 Dusp7 dual specificity phosphatase 7 (Dusp7), NM_153459 mRNA. 6839057 -0.75146 0.000709 Dnaja3 DnaJ (Hsp40) homolog, subfamily A, NM_023646 member 3 (Dnaja3), transcript variant 1, mRNA. 6811357 -0.75213 0.000968 Stard3nl STARD3 N-terminal like (Stard3nl), mRNA. NM_024270

6784039 -0.75245 0.008195 Psmd3 proteasome (prosome, macropain) 26S NM_009439 subunit, non-ATPase, 3 (Psmd3), mRNA.

6847632 -0.75293 0.005768 Cct8 chaperonin containing Tcp1, subunit 8 NM_009840 (theta) (Cct8), mRNA. 6888836 -0.75326 0.005667 Slc35c1 solute carrier family 35, member C1 NM_211358 (Slc35c1), transcript variant 1, mRNA. 6988773 -0.75366 0.005686 Zfp259 zinc finger protein 259 (Zfp259), mRNA. NM_011752 6809851 -0.75406 0.001437 Srek1ip1 splicing regulatory glutamine/lysine-rich NM_026075 protein 1interacting protein 1 (Srek1ip1), mRNA. 6990281 -0.75407 0.007942 Sltm SAFB-like, transcription modulator (Sltm), NM_025690 transcript variant 1, mRNA. 6882256 -0.75436 0.002964 2310046K01Ri RIKEN cDNA 2310046K01 gene NM_027172 k (2310046K01Rik), transcript variant 1, mRNA. 6993735 -0.75436 0.001686 Raver1 ribonucleoprotein, PTB-binding 1 (Raver1), NM_027911 mRNA. 6804696 -0.75485 0.001958 Larp4b La ribonucleoprotein domain family, NM_172585 member 4B (Larp4b), mRNA. 6760364 -0.75486 0.000551 Ncl nucleolin (Ncl), mRNA. NM_010880 6983265 -0.75489 0.00162 Bst2 bone marrow stromal cell antigen 2 (Bst2), NM_198095 mRNA. 6780694 -0.75516 0.003134 Gnb2l1 guanine nucleotide binding protein (G NM_008143 protein), beta polypeptide 2 like 1 (Gnb2l1), mRNA. 6864695 -0.75543 0.006292 Sra1 steroid receptor RNA activator 1 (Sra1), NR_028355 transcript variant 3, non-coding RNA. 6801332 -0.75546 0.003825 Fkbp3 FK506 binding protein 3 (Fkbp3), mRNA. NM_013902

6848568 -0.75574 0.00356 Ezr ezrin (Ezr), mRNA. NM_009510 6964241 -0.75701 9.29E-06 Bola2 bolA-like 2 (E. coli) (Bola2), mRNA. NM_175103 6785147 -0.75734 0.000306 Nup85 nucleoporin 85 (Nup85), mRNA. NM_001002929 6812770 -0.75741 0.000197 Tbc1d7 TBC1 domain family, member 7 (Tbc1d7), NM_025935 mRNA. 6961982 -0.75789 0.002464 Vps33b vacuolar protein sorting 33B (yeast) NM_178070 (Vps33b), mRNA. 6925590 -0.75803 0.000162 Txlna taxilin alpha (Txlna), mRNA. NM_001005506 6957462 -0.7584 0.000619 Magohb mago-nashi homolog B (Drosophila) NM_025564 (Magohb), mRNA. 7017052 -0.75857 0.008071 Arhgef6 Rac/Cdc42 guanine nucleotide exchange NM_152801 factor (GEF) 6 (Arhgef6), mRNA.

6760518 -0.75858 7.84E-06 Arl4c ADP-ribosylation factor-like 4C (Arl4c), NM_177305 mRNA. 6936585 -0.75957 0.000202 Dnajc2 DnaJ (Hsp40) homolog, subfamily C, NM_009584 member 2 (Dnajc2), mRNA. 6843624 -0.75963 0.000169 Btbd12 BTB (POZ) domain containing 12 (Btbd12), NM_177472 mRNA. 6969017 -0.75979 0.008821 Fam108c family with sequence similarity 108, NM_133722 member C (Fam108c), mRNA. 6844329 -0.76035 0.003765 Dgcr8 DiGeorge syndrome critical region gene 8 NM_033324 (Dgcr8), mRNA. 6883267 -0.76035 0.00462 Cse1l chromosome segregation 1-like (S. NM_023565 cerevisiae) (Cse1l), mRNA. 6774404 -0.76054 0.007609 Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_019553 21 (Ddx21), mRNA. 6804033 -0.76054 1.73E-05 Wdr60 WD repeat domain 60 (Wdr60), mRNA. NM_146039 6885395 -0.76082 0.001704 Ssna1 Sjogren's syndrome nuclear autoantigen 1 NM_023464 (Ssna1), mRNA. 6951440 -0.76099 0.0001 Slc25a13 solute carrier family 25 (mitochondrial NM_015829 carrier, adenine nucleotide translocator), member 13 (Slc25a13), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6828573 -0.76109 0.009637 Nup155 nucleoporin 155 (Nup155), mRNA. NM_133227 6809522 -0.76214 0.00289 Serf1 small EDRK-rich factor 1 (Serf1), mRNA. NM_011353

6917124 -0.76215 0.001918 Mrps15 mitochondrial ribosomal protein S15 NM_025544 (Mrps15), nuclear gene encoding mitochondrial protein, mRNA. 6870982 -0.76227 0.000473 Rad9 RAD9 homolog (S. pombe) (Rad9), mRNA. NM_011237

6826279 -0.76271 0.006546 Wbp4 WW domain binding protein 4 (Wbp4), NM_018765 mRNA. 6894278 -0.76507 0.004591 Gmeb2 glucocorticoid modulatory element binding NM_198169 protein 2 (Gmeb2), mRNA. 6994710 -0.76579 0.002268 Tbrg1 transforming growth factor beta regulated NM_025289 gene 1 (Tbrg1), mRNA. 6934311 -0.76597 0.000312 Ddx55 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_026409 55 (Ddx55), transcript variant 1, mRNA. 6807650 -0.76599 0.001907 0610007P08Ri RIKEN cDNA 0610007P08 gene NM_023507 k (0610007P08Rik), transcript variant 2, mRNA. 6966759 -0.76662 0.003978 C330019L16Ri RIKEN cDNA C330019L16 gene NM_001034857 k (C330019L16Rik), mRNA. 6882181 -0.76662 0.00722 Pygb brain glycogen phosphorylase (Pygb), NM_153781 mRNA. 6942544 -0.76705 0.007201 Srrt serrate RNA effector molecule homolog NM_031405 (Arabidopsis) (Srrt), transcript variant 1, mRNA. 6814385 -0.76706 0.004536 Pdcd6 programmed cell death 6 (Pdcd6), mRNA. NM_011051

7017627 -0.76712 0.000783 Ubl4 ubiquitin-like 4 (Ubl4), mRNA. NM_145405 6797880 -0.76725 0.00084 Ccnk cyclin K (Ccnk), mRNA. NM_009832 6769150 -0.76767 0.003642 Ptbp1 polypyrimidine tract binding protein 1 NM_001077363 (Ptbp1), transcript variant 1, mRNA. 6884710 -0.76779 0.000695 Rbm17 RNA binding motif protein 17 (Rbm17), NM_152824 mRNA. 6910948 -0.76839 0.007629 Srsf11 serine/arginine-rich splicing factor 11 NM_001093753 (Srsf11), transcript variant 1, mRNA. 6847880 -0.76844 0.009546 Gart phosphoribosylglycinamide NM_010256 formyltransferase (Gart), mRNA. 6991383 -0.76859 0.006397 Plod2 procollagen lysine, 2-oxoglutarate 5- NM_001142916 dioxygenase 2 (Plod2), transcript variant 1, mRNA. 6880322 -0.76865 0.004294 Spred1 sprouty protein with EVH-1 domain 1, NM_033524 related sequence (Spred1), mRNA. 6954619 -0.76871 0.002439 Vamp8 vesicle-associated membrane protein 8 NM_016794 (Vamp8), mRNA. 6993475 -0.76882 0.009597 Ankrd49 ankyrin repeat domain 49 (Ankrd49), NM_019683 mRNA. 6841410 -0.76885 0.002529 Cd47 CD47 antigen (Rh-related antigen, integrin- NM_010581 associated signal transducer) (Cd47), mRNA. 6866918 -0.76888 0.003555 Adnp2 ADNP homeobox 2 (Adnp2), mRNA. NM_175028 6826927 -0.76894 0.00326 Dis3 DIS3 mitotic control homolog (S. NM_028315 cerevisiae) (Dis3), mRNA. 6940863 -0.7697 0.001762 Glmn glomulin, FKBP associated protein (Glmn), NM_133248 transcript variant 1, mRNA. 6850022 -0.77041 0.004129 Tap2 transporter 2, ATP-binding cassette, sub- NM_011530 family B (MDR/TAP) (Tap2), mRNA. 6769304 -0.77041 0.007675 Aes amino-terminal enhancer of split (Aes), NM_010347 mRNA. 6871138 -0.77068 0.001354 Ehbp1l1 EH domain binding protein 1-like 1 NM_001114597 (Ehbp1l1), transcript variant A, mRNA. 6955935 -0.77074 0.00321 Eif4e3 eukaryotic translation initiation factor 4E NM_025829 member 3 (Eif4e3), mRNA. 6860635 -0.77078 0.001237 Eif1a eukaryotic translation initiation factor 1A NM_010120 (Eif1a), mRNA. 6803895 -0.771 0.009478 Akt1 thymoma viral proto-oncogene 1 (Akt1), NM_009652 transcript variant 1, mRNA. 6798312 -0.7711 0.000272 Mta1 metastasis associated 1 (Mta1), mRNA. NM_054081 6948003 -0.77114 0.006372 Tmem43 transmembrane protein 43 (Tmem43), NM_028766 mRNA. 6997215 -0.77153 0.00027 Tmem30a transmembrane protein 30A (Tmem30a), NM_133718 mRNA. 6756346 -0.77153 8.8E-05 Batf3 basic leucine zipper transcription factor, NM_030060 ATF-like 3 (Batf3), mRNA. 6757982 -0.77179 0.004384 Mitd1 MIT, microtubule interacting and transport, NM_026913 domain containing 1 (Mitd1), mRNA.

6782801 -0.77205 0.000285 Suz12 suppressor of zeste 12 homolog NM_199196 (Drosophila) (Suz12), transcript variant 1, mRNA. 6979636 -0.77259 0.004084 Cdt1 chromatin licensing and DNA replication NM_026014 factor 1 (Cdt1), mRNA. 6949064 -0.77275 0.000661 Setd5 SET domain containing 5 (Setd5), mRNA. NM_028385

6941344 -0.77347 0.001917 Cit 16 days embryo head cDNA, RIKEN full- AK047894 length enriched library, clone:C130020H05 product:unclassifiable, full insert sequence.

6843914 -0.77355 0.000523 Tnp2 transition protein 2 (Tnp2), mRNA. NM_013694 6964226 -0.77356 1.39E-05 Apob48r apolipoprotein B48 receptor (Apob48r), NM_138310 mRNA. 6916584 -0.77373 0.000166 Ccdc163 coiled-coil domain containing 163 NM_026714 (Ccdc163), mRNA. 6824902 -0.77466 0.002445 Pspc1 paraspeckle protein 1 (Pspc1), mRNA. NM_025682 6792107 -0.77534 0.00021 Fam20a family with sequence similarity 20, member NM_153782 A (Fam20a), mRNA. 6887819 -0.77595 0.003673 Ola1 Obg-like ATPase 1 (Ola1), transcript NM_025942 variant 1, mRNA. 6789066 -0.77598 0.007513 Map2k4 mitogen-activated protein kinase kinase 4 NM_009157 (Map2k4), mRNA. 6973282 -0.77619 0.003541 Rps5 ribosomal protein S5 (Rps5), mRNA. NM_009095 6995964 -0.77627 0.006725 Pml promyelocytic leukemia (Pml), transcript NM_178087 variant 2, mRNA. 6783674 -0.77641 0.001422 Lrrc59 leucine rich repeat containing 59 (Lrrc59), NM_133807 mRNA. 6795784 -0.77677 0.002405 Arf6 ADP-ribosylation factor 6 (Arf6), mRNA. NM_007481 6968772 -0.77684 0.006673 Cib1 calcium and integrin binding 1 (calmyrin) NM_011870 (Cib1), mRNA. 6867987 -0.77685 0.000679 Ahnak AHNAK nucleoprotein (desmoyokin) NM_009643 (Ahnak), transcript variant 1, mRNA. 6812984 -0.77702 0.002577 Dek DEK oncogene (DNA binding) (Dek), NM_025900 mRNA. 6876218 -0.77705 0.001433 Tor2a torsin family 2, member A (Tor2a), mRNA. NM_152800

6949084 -0.77749 0.004478 Arpc4 actin related protein 2/3 complex, subunit 4 NM_026552 (Arpc4), transcript variant 1, mRNA.

6866233 -0.77769 0.003041 Lman1 lectin, mannose-binding, 1 (Lman1), NM_027400 transcript variant 1, mRNA. 6823041 -0.77787 0.000613 Camk2g calcium/calmodulin-dependent protein NM_178597 kinase II gamma (Camk2g), transcript variant 1, mRNA. 6966991 -0.77802 0.00359 Ppp1r15a protein phosphatase 1, regulatory NM_008654 (inhibitor) subunit 15A (Ppp1r15a), mRNA. 7012561 -0.77824 2.27E-07 Pcyt1b phosphate cytidylyltransferase 1, choline, NM_211138 beta isoform (Pcyt1b), transcript variant 1, mRNA. 6952340 -0.77896 0.001415 Impdh1 inosine 5'-phosphate dehydrogenase 1 NM_011829 (Impdh1), mRNA. 6978948 -0.77935 0.009401 Nip7 nuclear import 7 homolog (S. cerevisiae) NR_028367 (Nip7), transcript variant 3, non-coding RNA. 6778506 -0.77959 0.002689 Dbnl drebrin-like (Dbnl), transcript variant 1, NM_001146308 mRNA. 6852845 -0.77961 5.18E-05 Rhoq ras homolog gene family, member Q NM_145491 (Rhoq), mRNA. 6832153 -0.77962 0.002424 Xrcc6 X-ray repair complementing defective NM_010247 repair in Chinese hamster cells 6 (Xrcc6), mRNA. 6941186 -0.78009 0.0006 Coro1c coronin, actin binding protein 1C (Coro1c), NM_011779 mRNA. 6947321 -0.78011 0.004052 AW146020 expressed sequence AW146020 NM_177884 (AW146020), mRNA. 6786473 -0.78084 9.13E-05 Slc1a4 solute carrier family 1 (glutamate/neutral NM_018861 amino acid transporter), member 4 (Slc1a4), mRNA. 6785808 -0.78107 0.000887 Tbrg4 transforming growth factor beta regulated NM_134011 gene 4 (Tbrg4), transcript variant 1, mRNA.

6934053 -0.78241 0.008005 Naa25 N(alpha)-acetyltransferase 25, NatB NM_172722 auxiliary subunit (Naa25), mRNA. 6802041 -0.78272 0.008774 Rdh11 retinol dehydrogenase 11 (Rdh11), mRNA. NM_021557

7009795 -0.78304 0.000259 Pim2 proviral integration site 2 (Pim2), mRNA. NM_138606 6790648 -0.78313 6.54E-05 Akap1 A kinase (PRKA) anchor protein 1 (Akap1), NM_009648 nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.

6968426 -0.78325 0.003438 Slco3a1 solute carrier organic anion transporter NM_023908 family, member 3a1 (Slco3a1), transcript variant 1, mRNA. 6964370 -0.78327 0.001741 Bckdk branched chain ketoacid dehydrogenase NM_009739 kinase (Bckdk), nuclear gene encoding mitochondrial protein, mRNA. 6837279 -0.78397 0.002012 St13 suppression of tumorigenicity 13 (St13), NM_133726 mRNA. 6875375 -0.78422 0.002387 Commd3 COMM domain containing 3 (Commd3), NM_147778 mRNA. 6792789 -0.78428 0.000108 Mafg v-maf musculoaponeurotic fibrosarcoma NM_010756 oncogene family, protein G (avian) (Mafg), mRNA. 6900456 -0.78446 0.003896 Vav3 vav 3 oncogene (Vav3), transcript variant NM_020505 1, mRNA. 6849326 -0.78455 0.002966 Mrps34 mitochondrial ribosomal protein S34 NM_023260 (Mrps34), nuclear gene encoding mitochondrial protein, mRNA. 6791479 -0.78496 0.004737 Ccdc56 coiled-coil domain containing 56 (Ccdc56), NM_026618 mRNA. 6994353 -0.78549 0.001413 St14 suppression of tumorigenicity 14 (colon NM_011176 carcinoma) (St14), mRNA. 6849347 -0.78654 0.000666 0610007P22Ri RIKEN cDNA 0610007P22 gene NM_026676 k (0610007P22Rik), transcript variant 1, mRNA. 6887196 -0.78657 0.003919 Ifih1 interferon induced with helicase C domain NM_027835 1 (Ifih1), transcript variant 1, mRNA.

6985006 -0.78708 0.000185 Slc12a4 solute carrier family 12, member 4 NM_009195 (Slc12a4), mRNA. 6995074 -0.78723 0.001265 Hmbs hydroxymethylbilane synthase (Hmbs), NM_013551 transcript variant 1, mRNA. 6797474 -0.78771 0.007461 Cpsf2 cleavage and polyadenylation specific NM_016856 factor 2 (Cpsf2), mRNA. 6768094 -0.78785 0.003699 Ranbp2 RAN binding protein 2 (Ranbp2), mRNA. NM_011240 6890125 -0.78853 0.003481 Srp14 signal recognition particle 14 (Srp14), NM_009273 mRNA. 6779162 -0.78897 0.003519 Spred2 sprouty-related, EVH1 domain containing 2 NM_033523 (Spred2), mRNA. 6805206 -0.78908 0.005357 Zscan12 zinc finger and SCAN domain containing NM_016684 12 (Zscan12), mRNA. 6779196 -0.78933 0.005567 Rab1 RAB1, member RAS oncogene family NM_008996 (Rab1), mRNA. 6918036 -0.78966 0.001695 Capzb capping protein (actin filament) muscle Z- NM_001037761 line, beta (Capzb), transcript variant 1, mRNA. 6994030 -0.78988 0.008064 Dpy19l1 dpy-19-like 1 (C. elegans) (Dpy19l1), NM_172920 mRNA. 6899687 -0.79045 0.001051 Ensa endosulfine alpha (Ensa), transcript variant NM_019561 1, mRNA. 6836366 -0.79183 0.005117 St3gal1 ST3 beta-galactoside alpha-2,3- NM_009177 sialyltransferase 1 (St3gal1), mRNA. 7009783 -0.79202 0.00024 Praf2 PRA1 domain family 2 (Praf2), mRNA. NM_138602 6935577 -0.79219 0.004972 Polr1d polymerase (RNA) I polypeptide D NM_181730 (Polr1d), transcript variant 2, mRNA. 6874626 -0.79253 0.003435 Sephs1 selenophosphate synthetase 1 (Sephs1), NM_175400 mRNA. 6775984 -0.79264 0.002197 Tmpo thymopoietin (Tmpo), transcript variant 3, NM_001080129 mRNA. 6878978 -0.79283 0.002132 Nup160 nucleoporin 160 (Nup160), mRNA. NM_021512 6908092 -0.79334 0.001491 Ampd2 adenosine monophosphate deaminase 2 NM_028779 (Ampd2), mRNA. 6854270 -0.79405 0.000358 Paqr4 progestin and adipoQ receptor family NM_023824 member IV (Paqr4), mRNA. 6921074 -0.79459 0.003219 Sigmar1 sigma non-opioid intracellular receptor 1 NM_011014 (Sigmar1), mRNA. 6771636 -0.79475 0.000182 Timeless timeless homolog (Drosophila) (Timeless), NM_001136082 transcript variant 1, mRNA. 6881118 -0.79522 0.000145 Chchd5 coiled-coil-helix-coiled-coil-helix domain NM_025395 containing 5 (Chchd5), mRNA. 6855772 -0.79549 0.001063 Bysl bystin-like (Bysl), mRNA. NM_016859 6792502 -0.7956 0.00472 Srp68 signal recognition particle 68 (Srp68), NM_146032 mRNA. 6819901 -0.79664 0.008466 Trim35 tripartite motif-containing 35 (Trim35), NM_029979 mRNA. 6749813 -0.79747 0.001097 Cyp20a1 cytochrome P450, family 20, subfamily A, NM_030013 polypeptide 1 (Cyp20a1), mRNA. 6868618 -0.79752 0.001111 Zfand5 zinc finger, AN1-type domain 5 (Zfand5), NM_009551 mRNA. 6813664 -0.79756 0.001859 Agtpbp1 ATP/GTP binding protein 1 (Agtpbp1), NM_023328 transcript variant 1, mRNA. 6758361 -0.79783 0.000112 Kdelc1 KDEL (Lys-Asp-Glu-Leu) containing 1 NM_023645 (Kdelc1), mRNA. 7017607 -0.79787 0.005943 Hcfc1 host cell factor C1 (Hcfc1), mRNA. NM_008224 6855202 -0.79841 0.003538 Ppp1r11 protein phosphatase 1, regulatory NM_029632 (inhibitor) subunit 11 (Ppp1r11), mRNA. 6808544 -0.79908 9.47E-05 Cetn3 centrin 3 (Cetn3), mRNA. NM_007684 6854930 -0.79948 0.008053 Zfp101 zinc finger protein 101 (Zfp101), mRNA. NM_009542 6974114 -0.79967 5.55E-06 Mcf2l mcf.2 transforming sequence-like (Mcf2l), NM_178076 transcript variant 1, mRNA. 6934942 -0.79985 0.006739 Mdh2 malate dehydrogenase 2, NAD NM_008617 (mitochondrial) (Mdh2), nuclear gene encoding mitochondrial protein, mRNA. 6946904 -0.80004 0.003 Krcc1 lysine-rich coiled-coil 1 (Krcc1), mRNA. NM_145568 6879659 -0.8001 0.002768 Cstf3 cleavage stimulation factor, 3' pre-RNA, NM_145529 subunit 3 (Cstf3), transcript variant 1, mRNA. 6864680 -0.80019 7.6E-05 Hbegf heparin-binding EGF-like growth factor NM_010415 (Hbegf), mRNA. 6813876 -0.80095 0.004829 Slc35d2 solute carrier family 35, member D2 NM_001001321 (Slc35d2), mRNA. 6792544 -0.80108 8.21E-05 St6galnac2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta- NM_009180 galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (St6galnac2), mRNA. 6933296 -0.80128 0.002893 Mtf2 metal response element binding NM_013827 transcription factor 2 (Mtf2), mRNA. 6926011 -0.80241 0.003907 Zfp593 zinc finger protein 593 (Zfp593), mRNA. NM_024215 6982158 -0.80261 0.000291 Slc25a4 solute carrier family 25 (mitochondrial NM_007450 carrier, adenine nucleotide translocator), member 4 (Slc25a4), nuclear gene encoding mitochondrial protein, mRNA. 6783264 -0.80356 0.003478 Ptrh2 peptidyl-tRNA hydrolase 2 (Ptrh2), nuclear NM_175004 gene encoding mitochondrial protein, transcript variant 1, mRNA. 6819152 -0.8036 0.001651 Mrpl52 mitochondrial ribosomal protein L52 NM_026851 (Mrpl52), nuclear gene encoding mitochondrial protein, mRNA. 6833430 -0.8038 2.53E-06 Tarbp2 TAR (HIV) RNA binding protein 2 (Tarbp2), NM_009319 mRNA. 6791942 -0.80417 0.003672 Tex2 testis expressed gene 2 (Tex2), mRNA. NM_198292 6993760 -0.80436 0.002072 Kri1 KRI1 homolog (S. cerevisiae) (Kri1), NM_145416 mRNA. 6972990 -0.80468 0.004905 Ube2m ubiquitin-conjugating enzyme E2M (UBC12 NM_145578 homolog, yeast) (Ube2m), transcript variant 1, mRNA. 6978296 -0.80532 0.003048 Nup93 nucleoporin 93 (Nup93), mRNA. NM_172410 6850791 -0.8054 4.2E-05 Usp49 ubiquitin specific peptidase 49 (Usp49), NM_198421 mRNA. 6748736 -0.80636 0.009885 Eif5b eukaryotic translation initiation factor 5B NM_198303 (Eif5b), mRNA. 6989983 -0.8066 0.002555 Csnk1g1 casein kinase 1, gamma 1 (Csnk1g1), NM_173185 mRNA. 6966875 -0.80702 6.21E-06 Pold1 polymerase (DNA directed), delta 1, NM_011131 catalytic subunit (Pold1), mRNA. 6781487 -0.80769 0.000326 Map2k3 mitogen-activated protein kinase kinase 3 NM_008928 (Map2k3), mRNA. 6838032 -0.80865 0.006406 Yaf2 YY1 associated factor 2 (Yaf2), transcript NR_028315 variant 2, non-coding RNA. 6791465 -0.80885 0.000277 Psmc3ip proteasome (prosome, macropain) 26S NM_008949 subunit, ATPase 3, interacting protein (Psmc3ip), mRNA. 6806444 -0.80962 0.004962 Tmem14c transmembrane protein 14C (Tmem14c), NM_025387 mRNA. 6907912 -0.8106 0.005268 Ddx20 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_017397 20 (Ddx20), mRNA. 6837102 -0.81061 0.000119 Tmem184b transmembrane protein 184b NM_172608 (Tmem184b), mRNA. 6774947 -0.81121 0.00059 Cisd1 CDGSH iron sulfur domain 1 (Cisd1), NM_134007 mRNA. 6985117 -0.81141 0.00307 Psmd7 proteasome (prosome, macropain) 26S NM_010817 subunit, non-ATPase, 7 (Psmd7), mRNA.

6837320 -0.81154 0.007163 Phf5a PHD finger protein 5A (Phf5a), mRNA. NM_026737 6855006 -0.81193 0.001813 Brd2 bromodomain containing 2 (Brd2), NM_010238 transcript variant 1, mRNA. 6824610 -0.81217 0.004882 Ndrg2 N-myc downstream regulated gene 2 NM_013864 (Ndrg2), transcript variant 1, mRNA. 6813327 -0.81217 0.002399 Cltb clathrin, light polypeptide (Lcb) (Cltb), NM_028870 mRNA. 6890991 -0.81239 0.000111 Cenpb centromere protein B (Cenpb), mRNA. NM_007682 6924952 -0.81292 0.001742 AU022252 expressed sequence AU022252 NM_001012400 (AU022252), mRNA. 6982580 -0.81322 0.001101 Spcs3 signal peptidase complex subunit 3 NM_029701 homolog (S. cerevisiae) (Spcs3), mRNA. 6992367 -0.81345 0.004253 Prkar2a protein kinase, cAMP dependent NM_008924 regulatory, type II alpha (Prkar2a), mRNA.

6792784 -0.81359 0.000907 Thoc4 THO complex 4 (Thoc4), mRNA. NM_011568 6892990 -0.81368 0.000487 Slc35c2 solute carrier family 35, member C2 NM_144893 (Slc35c2), mRNA. 6893249 -0.81436 0.007201 Adnp activity-dependent neuroprotective protein NM_009628 (Adnp), mRNA. 6977139 -0.81506 0.001819 Tpm4 tropomyosin 4 (Tpm4), mRNA. NM_001001491 6830510 -0.81521 0.005938 Mtbp Mdm2, transformed 3T3 cell double minute NM_134092 p53 binding protein (Mtbp), transcript variant 1, mRNA. 6880640 -0.81555 0.002615 Pdia3 protein disulfide isomerase associated 3 NM_007952 (Pdia3), mRNA. 6781441 -0.81578 0.007561 Drg2 developmentally regulated GTP binding NM_021354 protein 2 (Drg2), mRNA. 7011907 -0.81597 0.004735 Nsdhl NAD(P) dependent steroid dehydrogenase- NM_010941 like (Nsdhl), mRNA. 6762141 -0.81668 2.27E-06 Dyrk3 dual-specificity tyrosine-(Y)- NM_145508 phosphorylation regulated kinase 3 (Dyrk3), mRNA. 6792792 -0.81672 0.00011 Pycr1 pyrroline-5-carboxylate reductase 1 NM_144795 (Pycr1), mRNA. 6820033 -0.81675 0.001149 Entpd4 ectonucleoside triphosphate NM_026174 diphosphohydrolase 4 (Entpd4), mRNA. 6987107 -0.81739 0.002727 Mre11a meiotic recombination 11 homolog A (S. NM_018736 cerevisiae) (Mre11a), mRNA. 6839334 -0.81786 0.002572 Nubp1 nucleotide binding protein 1 (Nubp1), NM_011955 mRNA. 6958059 -0.81791 0.004519 Ldhb lactate dehydrogenase B (Ldhb), mRNA. NM_008492 6793649 -0.8185 0.000519 E2f6 E2F transcription factor 6 (E2f6), transcript NR_027677 variant 2, non-coding RNA. 6933072 -0.81876 0.001646 Spp1 secreted phosphoprotein 1 (Spp1), mRNA. NM_009263

6784329 -0.81905 9.58E-05 BC030867 cDNA sequence BC030867 (BC030867), NM_153544 mRNA. 6992849 -0.81944 0.000659 Eomes eomesodermin homolog (Xenopus laevis) NM_010136 (Eomes), transcript variant 1, mRNA.

6992415 -0.81954 0.000148 Mtap4 microtubule-associated protein 4 (Mtap4), NM_008633 mRNA. 6950770 -0.81957 0.00393 Golt1b golgi transport 1 homolog B (S. cerevisiae) NM_025872 (Golt1b), mRNA. 6763275 -0.81976 0.000506 Fam20b family with sequence similarity 20, member NM_145413 B (Fam20b), mRNA. 6794331 -0.81999 0.000277 Atxn7l1 ataxin 7-like 1 (Atxn7l1), transcript variant NM_001033436 1, mRNA. 6960723 -0.82001 8.48E-07 Gas2 growth arrest specific 2 (Gas2), mRNA. NM_008087 6785236 -0.82003 0.006557 1810032O08Ri RIKEN cDNA 1810032O08 gene NR_027821 k (1810032O08Rik), transcript variant 3, non- coding RNA. 6913286 -0.82036 0.000578 Sec61b Sec61 beta subunit (Sec61b), mRNA. NM_024171 6945032 -0.82054 1.21E-06 Smo smoothened homolog (Drosophila) (Smo), NM_176996 mRNA. 6917215 -0.82067 0.007606 Zmym6 zinc finger, MYM-type 6 (Zmym6), mRNA. NM_177462

6942617 -0.82069 0.007121 BC037034 cDNA sequence BC037034 (BC037034), NM_153161 mRNA. 6929856 -0.82087 0.003461 Htt huntingtin (Htt), mRNA. NM_010414 6871255 -0.82228 0.002027 Ccdc88b coiled-coil domain containing 88B NM_001081291 (Ccdc88b), mRNA. 6977676 -0.82266 0.003871 Dnajb1 DnaJ (Hsp40) homolog, subfamily B, NM_018808 member 1 (Dnajb1), mRNA. 6777182 -0.82358 0.001874 Thap2 THAP domain containing, apoptosis NM_025780 associated protein 2 (Thap2), mRNA. 6870470 -0.82389 0.001712 Smc3 structural maintenace of chromosomes 3 NM_007790 (Smc3), mRNA. 6934652 -0.82447 1.77E-06 Tpst1 protein-tyrosine sulfotransferase 1 (Tpst1), NM_001130476 transcript variant 1, mRNA. 6771794 -0.82468 0.00097 5830405N20Ri RIKEN cDNA 5830405N20 gene NM_183264 k (5830405N20Rik), mRNA. 6863156 -0.82498 0.002068 Arhgap12 Rho GTPase activating protein 12 NM_001039692 (Arhgap12), transcript variant 1, mRNA. 6817136 -0.82523 0.003492 Ngly1 N-glycanase 1 (Ngly1), mRNA. NM_021504 6867966 -0.82532 0.006316 Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-NM_001081196 like 2 (Hnrnpul2), mRNA. 6944997 -0.82549 0.002177 Calu calumenin (Calu), transcript variant 1, NM_007594 mRNA. 6917512 -0.82564 0.000232 Rcc1 regulator of chromosome condensation 1 NM_001197082 (Rcc1), transcript variant 1, mRNA. 6975876 -0.82582 0.00452 Ufsp2 UFM1-specific peptidase 2 (Ufsp2), NM_138668 mRNA. 6855013 -0.82595 0.004533 Psmb9 proteasome (prosome, macropain) subunit, NM_013585 beta type 9 (large multifunctional peptidase 2) (Psmb9), mRNA.

6849534 -0.82671 0.001256 Def6 differentially expressed in FDCP 6 (Def6), NM_027185 mRNA. 6855610 -0.82746 0.000544 Hsp90ab1 heat shock protein 90 alpha (cytosolic), NM_008302 class B member 1 (Hsp90ab1), mRNA. 6791428 -0.82778 0.002255 Acly ATP citrate lyase (Acly), mRNA. NM_134037 6903946 -0.82822 0.000464 Phc3 polyhomeotic-like 3 (Drosophila) (Phc3), NM_001165954 transcript variant 1, mRNA. 6872292 -0.829 0.000365 Cbwd1 COBW domain containing 1 (Cbwd1), NR_033744 transcript variant 2, non-coding RNA. 6824834 -0.82922 0.006483 Nedd8 neural precursor cell expressed, NM_008683 developmentally down-regulated gene 8 (Nedd8), mRNA. 6993501 -0.83002 0.009036 Fat3 FAT tumor suppressor homolog 3 NM_001080814 (Drosophila) (Fat3), mRNA. 6996695 -0.83004 0.000901 Gcom1 GRINL1A complex locus (Gcom1), mRNA. NM_001033208

6942176 -0.83022 0.000616 Psph phosphoserine phosphatase (Psph), NM_133900 mRNA. 6963384 -0.83141 0.006609 D930014E17Ri RIKEN cDNA D930014E17 gene NM_020616 k (D930014E17Rik), mRNA. 6905746 -0.83143 0.002141 Lxn latexin (Lxn), mRNA. NM_016753 6880621 -0.83191 0.00585 Wdr76 WD repeat domain 76 (Wdr76), mRNA. NM_030234 6780779 -0.83204 0.005063 Tbc1d9b TBC1 domain family, member 9B NM_029745 (Tbc1d9b), mRNA. 6858456 -0.83282 0.004107 Cul2 cullin 2 (Cul2), mRNA. NM_029402 6967882 -0.83328 0.008852 Mphosph10 M-phase phosphoprotein 10 (U3 small NM_026483 nucleolar ribonucleoprotein) (Mphosph10), mRNA. 6783363 -0.83338 1.92E-06 Cuedc1 CUE domain containing 1 (Cuedc1), NM_198013 transcript variant 1, mRNA. 6886768 -0.8335 0.00227 Prpf40a PRP40 pre-mRNA processing factor 40 NM_018785 homolog A (yeast) (Prpf40a), mRNA. 7016751 -0.83389 0.000282 Enox2 ecto-NOX disulfide-thiol exchanger 2 NM_145951 (Enox2), mRNA. 6825688 -0.83406 9.98E-06 Slc39a14 solute carrier family 39 (zinc transporter), NM_144808 member 14 (Slc39a14), transcript variant 3, mRNA. 6887836 -0.83453 0.000328 Wipf1 WAS/WASL interacting protein family, NM_153138 member 1 (Wipf1), mRNA. 6766595 -0.83504 0.001084 Stx7 syntaxin 7 (Stx7), mRNA. NM_016797 6753316 -0.83516 7.38E-05 Ube2t ubiquitin-conjugating enzyme E2T NM_026024 (putative) (Ube2t), mRNA. 6944384 -0.83524 0.000204 Capza2 capping protein (actin filament) muscle Z- NM_007604 line, alpha 2 (Capza2), mRNA. 6915567 -0.83536 0.001663 Hook1 hook homolog 1 (Drosophila) (Hook1), NM_030014 mRNA. 6999404 -0.83587 0.003153 Plcd1 phospholipase C, delta 1 (Plcd1), mRNA. NM_019676

6883329 -0.83593 1.44E-05 Cebpb CCAAT/enhancer binding protein (C/EBP), NM_009883 beta (Cebpb), mRNA. 6790966 -0.83618 0.000643 Eme1 essential meiotic endonuclease 1 homolog NM_177752 1 (S. pombe) (Eme1), mRNA. 6882581 -0.83637 0.000275 Cep250 centrosomal protein 250 (Cep250), NM_001129999 transcript variant 3, mRNA. 6962935 -0.83655 0.002283 Ucp2 uncoupling protein 2 (mitochondrial, proton NM_011671 carrier) (Ucp2), nuclear gene encoding mitochondrial protein, mRNA. 6980547 -0.83811 0.000258 Dcun1d2 DCN1, defective in cullin neddylation 1, NM_001024504 domain containing 2 (S. cerevisiae) (Dcun1d2), transcript variant 1, mRNA. 6842503 -0.83835 0.001813 Usp25 ubiquitin specific peptidase 25 (Usp25), NM_013918 mRNA. 6930484 -0.83844 0.000266 Lap3 leucine aminopeptidase 3 (Lap3), mRNA. NM_024434

6820084 -0.83996 0.00053 Reep4 receptor accessory protein 4 (Reep4), NM_180588 mRNA. 6872646 -0.84 1.58E-05 Asah2 N-acylsphingosine amidohydrolase 2 NM_018830 (Asah2), mRNA. 6875094 -0.84039 0.002976 Pter phosphotriesterase related (Pter), mRNA. NM_008961

6879621 -0.84062 0.000403 Abtb2 ankyrin repeat and BTB (POZ) domain NM_178890 containing 2 (Abtb2), mRNA. 6981924 -0.84064 0.006422 Asah1 N-acylsphingosine amidohydrolase 1 NM_019734 (Asah1), mRNA. 6790245 -0.84072 0.008996 Slfn10-ps schlafen 10, pseudogene (Slfn10-ps), NM_181542 mRNA. 6916996 -0.84126 0.000567 Mycbp c-myc binding protein (Mycbp), mRNA. NM_019660 6927145 -0.84151 0.004398 Kcnab2 potassium voltage-gated channel, shaker- NM_010598 related subfamily, beta member 2 (Kcnab2), mRNA. 6919184 -0.84171 0.007117 Mrpl20 // mitochondrial ribosomal protein L20 NM_025570 Mrpl20 (Mrpl20), nuclear gene encoding mitochondrial protein, mRNA. 6812894 -0.84187 0.001362 Atxn1 ataxin 1 (Atxn1), mRNA. NM_009124 6954584 -0.84213 0.004181 Mrpl35 mitochondrial ribosomal protein L35 NM_025430 (Mrpl35), nuclear gene encoding mitochondrial protein, mRNA. 6912887 -0.84229 0.000752 Nfx1 nuclear transcription factor, X-box binding NM_023739 1 (Nfx1), mRNA. 6971227 -0.84256 0.000444 Nsmce1 non-SMC element 1 homolog (S. NM_026330 cerevisiae) (Nsmce1), mRNA. 6793674 -0.84285 0.008142 Nol10 nucleolar protein 10 (Nol10), mRNA. NM_001008421 6969788 -0.84297 0.005099 Pold3 polymerase (DNA-directed), delta 3, NM_133692 accessory subunit (Pold3), mRNA. 6848504 -0.84334 0.000661 Snx9 sorting nexin 9 (Snx9), mRNA. NM_025664 6870897 -0.84346 3.33E-05 Grk5 G protein-coupled receptor kinase 5 NM_018869 (Grk5), mRNA. 6957124 -0.84352 0.000141 Atn1 atrophin 1 (Atn1), mRNA. NM_007881 6996254 -0.84447 0.009377 Smad3 MAD homolog 3 (Drosophila) (Smad3), NM_016769 mRNA. 6995717 -0.84461 6.69E-05 Acat1 acetyl-Coenzyme A acetyltransferase 1 NM_144784 (Acat1), nuclear gene encoding mitochondrial protein, mRNA. 6888720 -0.84486 0.001145 Ptpmt1 protein tyrosine phosphatase, NM_025576 mitochondrial 1 (Ptpmt1), nuclear gene encoding mitochondrial protein, mRNA. 6884446 -0.84486 1.38E-06 Optn optineurin (Optn), mRNA. NM_181848 6750351 -0.84489 0.001986 Atic 5-aminoimidazole-4-carboxamide NM_026195 ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), mRNA. 6853944 -0.84502 0.002585 Psmb1 proteasome (prosome, macropain) subunit, NM_011185 beta type 1 (Psmb1), mRNA. 6946912 -0.84518 0.000881 Cd8b1 CD8 antigen, beta chain 1 (Cd8b1), NM_009858 mRNA. 6826116 -0.84591 5.18E-06 9030625A04Ri RIKEN cDNA 9030625A04 gene, mRNA BC116748 k (cDNA clone MGC:151125 IMAGE:40126067), complete cds. 6854844 -0.846 0.009419 Sik1 salt inducible kinase 1 (Sik1), mRNA. NM_010831 6753338 -0.84635 0.000612 Arl8a ADP-ribosylation factor-like 8A (Arl8a), NM_026823 mRNA. 6764011 -0.84646 0.002995 Uap1 UDP-N-acetylglucosamine NM_133806 pyrophosphorylase 1 (Uap1), mRNA. 6941734 -0.84647 0.000123 Rad9b RAD9 homolog B (S. cerevisiae) (Rad9b), NM_144912 mRNA. 6888153 -0.84665 0.000159 Nckap1 NCK-associated protein 1 (Nckap1), NM_016965 mRNA. 6838386 -0.84674 0.000103 Adcy6 adenylate cyclase 6 (Adcy6), mRNA. NM_007405 6906634 -0.84707 0.000123 Dclk2 doublecortin-like kinase 2 (Dclk2), NM_001195496 transcript variant 1, mRNA. 6998401 -0.8471 0.001596 Cdv3 carnitine deficiency-associated gene NM_175565 expressed in ventricle 3 (Cdv3), transcript variant 1, mRNA. 6911925 -0.84784 0.000719 Nbn nibrin (Nbn), mRNA. NM_013752 6788388 -0.8479 0.006194 Anxa6 annexin A6 (Anxa6), transcript variant 1, NM_013472 mRNA. 6988636 -0.84861 8.8E-06 Slc37a4 solute carrier family 37 (glucose-6- NM_008063 phosphate transporter), member 4 (Slc37a4), mRNA. 6776105 -0.84871 0.000515 Vezt vezatin, adherens junctions NM_172538 transmembrane protein (Vezt), mRNA. 6853910 -0.84879 0.002535 Phf10 PHD finger protein 10 (Phf10), mRNA. NM_024250 6839552 -0.84899 0.002798 Nde1 nuclear distribution gene E homolog 1 (A NM_023317 nidulans) (Nde1), transcript variant a, mRNA. 6949473 -0.85008 0.008075 Fbxl14 F-box and leucine-rich repeat protein 14 NM_133940 (Fbxl14), mRNA. 6755540 -0.85072 0.00501 Pppde1 PPPDE peptidase domain containing 1 NM_024282 (Pppde1), mRNA. 6824740 -0.85088 0.002437 Haus4 HAUS augmin-like complex, subunit 4 NM_145462 (Haus4), mRNA. 6768123 -0.85176 0.000575 P4ha1 procollagen-proline, 2-oxoglutarate 4- NM_011030 dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide (P4ha1), mRNA. 6937597 -0.85216 0.006338 Wdr1 WD repeat domain 1 (Wdr1), mRNA. NM_011715 7018671 -0.85382 0.006079 Rlim ring finger protein, LIM domain interacting NM_011276 (Rlim), mRNA. 6861722 -0.85412 0.000472 Psmg2 proteasome (prosome, macropain) NM_134138 assembly chaperone 2 (Psmg2), mRNA. 6837809 -0.85416 0.000636 Lmf2 lipase maturation factor 2 (Lmf2), mRNA. NM_178919

6753179 -0.85435 0.001251 Ppp1r15b protein phosphatase 1, regulatory NM_133819 (inhibitor) subunit 15b (Ppp1r15b), mRNA.

6856208 -0.85501 0.009854 D17Wsu104e DNA segment, Chr 17, Wayne State NM_080837 University 104, expressed (D17Wsu104e), mRNA. 6899152 -0.8553 0.006527 Rit1 Ras-like without CAAX 1 (Rit1), transcript NR_028056 variant 3, non-coding RNA. 6789741 -0.85623 0.000552 Serpinf1 serine (or cysteine) peptidase inhibitor, NM_011340 clade F, member 1 (Serpinf1), mRNA. 6817396 -0.85686 0.007767 Adk adenosine kinase (Adk), mRNA. NM_134079 6800894 -0.85718 0.00448 Snx6 sorting nexin 6 (Snx6), mRNA. NM_026998 6796345 -0.85741 7.01E-08 Rad51l1 RAD51-like 1 (S. cerevisiae) (Rad51l1), NM_009014 mRNA. 6973761 -0.85744 0.005745 BC003267 cDNA sequence BC003267 (BC003267), NM_145591 mRNA. 6903099 -0.85779 0.000973 Tpd52 tumor protein D52 (Tpd52), transcript NM_001025261 variant 1, mRNA. 6985408 -0.858 0.001368 Cfdp1 craniofacial development protein 1 (Cfdp1), NM_011801 mRNA. 6873744 -0.85881 0.001329 Xpnpep1 X-prolyl aminopeptidase (aminopeptidase NM_133216 P) 1, soluble (Xpnpep1), mRNA.

6769193 -0.85918 0.000278 Midn midnolin (Midn), mRNA. NM_021565 6917981 -0.85958 0.003693 Ddost dolichyl-di-phosphooligosaccharide-protein NM_007838 glycotransferase (Ddost), mRNA. 6944952 -0.85962 0.001464 Snd1 staphylococcal nuclease and tudor domain NM_019776 containing 1 (Snd1), mRNA. 6769201 -0.85996 0.000604 Mum1 melanoma associated antigen (mutated) 1 NM_023431 (Mum1), mRNA. 6748832 -0.85998 0.000663 Pdcl3 phosducin-like 3 (Pdcl3), mRNA. NM_026850 6752409 -0.86066 0.002886 Mki67ip Mki67 (FHA domain) interacting nucleolar NM_026472 phosphoprotein (Mki67ip), mRNA.

7018510 -0.86089 0.000671 Pdzd11 PDZ domain containing 11 (Pdzd11), NM_028303 mRNA. 6846197 -0.86096 0.002421 Bbx bobby sox homolog (Drosophila) (Bbx), NM_027444 mRNA. 6898775 -0.8625 0.002945 Plrg1 pleiotropic regulator 1, PRL1 homolog NM_016784 (Arabidopsis) (Plrg1), mRNA. 6966265 -0.86347 0.000747 Tbcb tubulin folding cofactor B (Tbcb), mRNA. NM_025548 6807998 -0.86369 0.008032 Nsun2 NOL1/NOP2/Sun domain family member 2 NM_145354 (Nsun2), mRNA. 6870068 -0.865 5.42E-07 Tmem180 transmembrane protein 180 (Tmem180), NM_029186 mRNA. 6764056 -0.86561 0.00179 Ufc1 ubiquitin-fold modifier conjugating enzyme NM_025388 1 (Ufc1), mRNA. 6757129 -0.86564 0.001587 Tceb1 transcription elongation factor B (SIII), NM_026456 polypeptide 1 (Tceb1), mRNA. 6980124 -0.86581 0.001794 Timm44 translocase of inner mitochondrial NM_011592 membrane 44 (Timm44), nuclear gene encoding mitochondrial protein, mRNA. 6780544 -0.86603 0.007121 Med7 mediator complex subunit 7 (Med7), NM_025426 transcript variant 1, mRNA. 6935094 -0.86629 1.09E-06 Zcwpw1 zinc finger, CW type with PWWP domain 1 NM_001005426 (Zcwpw1), mRNA. 6749763 -0.86694 0.003311 Fzd7 frizzled homolog 7 (Drosophila) (Fzd7), NM_008057 mRNA. 6819247 -0.86758 1.23E-05 Pck2 phosphoenolpyruvate carboxykinase 2 NM_028994 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA. 6756238 -0.86832 1.16E-05 Ptpn14 protein tyrosine phosphatase, non-receptor NM_008976 type 14 (Ptpn14), mRNA. 6781083 -0.86873 2.33E-06 Hint1 histidine triad nucleotide binding protein 1 NM_008248 (Hint1), mRNA. 6959453 -0.86887 0.002381 Rinl Ras and Rab interactor-like (Rinl), mRNA. NM_177158

6913638 -0.86961 0.002271 Rad23b RAD23b homolog (S. cerevisiae) NM_009011 (Rad23b), mRNA. 6754143 -0.86962 0.001484 Rnasel ribonuclease L (2', 5'-oligoisoadenylate NM_011882 synthetase-dependent) (Rnasel), mRNA. 6849098 -0.86996 0.00413 BC049807 cDNA sequence BC049807, mRNA (cDNA BC076634 clone MGC:100178 IMAGE:30659397), complete cds. 6971274 -0.8706 0.000184 Cln3 ceroid lipofuscinosis, neuronal 3, juvenile NM_001146311 (Batten, Spielmeyer-Vogt disease) (Cln3), transcript variant 1, mRNA.

6893147 -0.87082 0.000204 B4galt5 UDP-Gal:betaGlcNAc beta 1,4- NM_019835 galactosyltransferase, polypeptide 5 (B4galt5), mRNA. 6854983 -0.8711 0.000173 H2-Ke2 H2-K region expressed gene 2 (H2-Ke2), NM_010385 transcript variant 1, mRNA. 6950103 -0.87252 0.001979 Clec2i C-type lectin domain family 2, member i NM_020257 (Clec2i), mRNA. 6943310 -0.87401 0.002889 Hsph1 heat shock 105kDa/110kDa protein 1 NM_013559 (Hsph1), mRNA. 6949849 -0.87406 0.000536 Nop2 NOP2 nucleolar protein homolog (yeast) NM_138747 (Nop2), mRNA. 6977260 -0.87463 1.04E-05 Hmox1 heme oxygenase (decycling) 1 (Hmox1), NM_010442 mRNA. 6769358 -0.87511 0.000811 Eid3 EP300 interacting inhibitor of differentiation NM_025499 3 (Eid3), mRNA. 6849973 -0.87579 0.009555 Ndufa7 NADH dehydrogenase (ubiquinone) 1 NM_023202 alpha subcomplex, 7 (B14.5a) (Ndufa7), nuclear gene encoding mitochondrial protein, mRNA. 6960382 -0.87597 3.55E-07 Bcat2 branched chain aminotransferase 2, NM_009737 mitochondrial (Bcat2), nuclear gene encoding mitochondrial protein, mRNA. 6983624 -0.87603 0.003469 Abce1 ATP-binding cassette, sub-family E NM_015751 (OABP), member 1 (Abce1), mRNA. 6940648 -0.87677 0.005492 Gbp4 guanylate binding protein 4 (Gbp4), mRNA. NM_008620

6778043 -0.87701 0.002682 Pa2g4 proliferation-associated 2G4 (Pa2g4), NM_011119 mRNA. 6925054 -0.87711 0.001812 Ctps cytidine 5'-triphosphate synthase (Ctps), NM_016748 mRNA. 6981683 -0.87733 0.002859 Eri1 exoribonuclease 1 (Eri1), mRNA. NM_026067 6835640 -0.87802 0.000567 Rad21 RAD21 homolog (S. pombe) (Rad21), NM_009009 mRNA. 6985848 -0.87893 6.75E-05 Gins2 GINS complex subunit 2 (Psf2 homolog) NM_178856 (Gins2), mRNA. 6769634 -0.87897 0.001085 Gnptab N-acetylglucosamine-1-phosphate NM_001004164 transferase, alpha and beta subunits (Gnptab), mRNA. 6994668 -0.87935 0.003314 Ei24 etoposide induced 2.4 mRNA (Ei24), NM_007915 mRNA. 6775250 -0.87942 0.009282 Agpat3 1-acylglycerol-3-phosphate O- NM_053014 acyltransferase 3 (Agpat3), mRNA. 6884788 -0.88118 8.41E-05 Rsu1 Ras suppressor protein 1 (Rsu1), mRNA. NM_009105

6950792 -0.88146 0.005583 Cmas cytidine monophospho-N-acetylneuraminic NM_009908 acid synthetase (Cmas), mRNA.

6785799 -0.88153 0.004943 Myo1g myosin IG (Myo1g), mRNA. NM_178440 6866839 -0.88158 0.000792 Haus1 HAUS augmin-like complex, subunit 1 NM_146089 (Haus1), mRNA. 6882515 -0.88181 0.00129 Dynlrb1 dynein light chain roadblock-type 1 NM_025947 (Dynlrb1), mRNA. 6775473 -0.8822 0.000935 Gna11 guanine nucleotide binding protein, alpha NM_010301 11 (Gna11), mRNA. 6977012 -0.88324 0.002871 Fkbp8 FK506 binding protein 8 (Fkbp8), transcript NM_001111066 variant 1, mRNA. 6855145 -0.88339 0.001192 Mrps18b mitochondrial ribosomal protein S18B NM_025878 (Mrps18b), nuclear gene encoding mitochondrial protein, mRNA. 6999348 -0.8845 0.00087 Cmc1 COX assembly mitochondrial protein NM_026442 homolog (S. cerevisiae) (Cmc1), nuclear gene encoding mitochondrial protein, mRNA. 6802749 -0.88515 0.001667 Sel1l sel-1 suppressor of lin-12-like (C. elegans) NM_001039089 (Sel1l), transcript variant 1, mRNA.

6987641 -0.88603 0.002073 Ncapd3 non-SMC condensin II complex, subunit NM_178113 D3 (Ncapd3), mRNA. 6845154 -0.88609 0.001116 Lrrc33 leucine rich repeat containing 33 (Lrrc33), NM_146069 mRNA. 6965658 -0.88654 0.002092 Calm3 calmodulin 3 (Calm3), mRNA. NM_007590 6850071 -0.88661 0.000172 Rdbp RD RNA-binding protein (Rdbp), transcript NM_001045864 variant 3, mRNA. 6936690 -0.88739 0.001198 Pus7 pseudouridylate synthase 7 homolog (S. NM_178403 cerevisiae) (Pus7), mRNA. 6809550 -0.88899 0.006701 Taf9 TAF9 RNA polymerase II, TATA box NM_027592 binding protein (TBP)-associated factor (Taf9), transcript variant 2, mRNA. 6922883 -0.88909 0.00364 Zdhhc21 zinc finger, DHHC domain containing 21 NM_026647 (Zdhhc21), mRNA. 6907638 -0.88912 0.006618 Atp1a1 ATPase, Na+/K+ transporting, alpha 1 NM_144900 polypeptide (Atp1a1), mRNA. 6992632 -0.88992 0.001312 Glb1 galactosidase, beta 1 (Glb1), mRNA. NM_009752 6792781 -0.89005 0.000794 Arhgdia Rho GDP dissociation inhibitor (GDI) alpha NM_133796 (Arhgdia), mRNA. 6873960 -0.89014 3.75E-07 Dclre1a DNA cross-link repair 1A, PSO2 homolog NM_018831 (S. cerevisiae) (Dclre1a), mRNA.

6959457 -0.89119 0.000439 Hnrnpl heterogeneous nuclear ribonucleoprotein L NM_177301 (Hnrnpl), mRNA. 6905588 -0.89146 0.002196 Slc33a1 solute carrier family 33 (acetyl-CoA NM_015728 transporter), member 1 (Slc33a1), mRNA.

6976988 -0.89188 0.004031 Cope coatomer protein complex, subunit epsilon NM_021538 (Cope), mRNA. 6972181 -0.89197 0.001662 Hras1 Harvey rat sarcoma virus oncogene 1 NM_001130444 (Hras1), transcript variant 2, mRNA. 6872426 -0.89199 0.001032 D19Bwg1357e DNA segment, Chr 19, Brigham & NM_177474 Women's Genetics 1357 expressed (D19Bwg1357e), mRNA. 6969255 -0.89213 0.001328 Eed embryonic ectoderm development (Eed), NM_021876 mRNA. 7015447 -0.89268 0.004011 Was Wiskott-Aldrich syndrome homolog NM_009515 (human) (Was), mRNA. 6862247 -0.89286 0.00025 Ier3ip1 immediate early response 3 interacting NM_025409 protein 1 (Ier3ip1), mRNA. 6847748 -0.89312 0.000164 Tiam1 T-cell lymphoma invasion and metastasis 1 NM_009384 (Tiam1), transcript variant 1, mRNA.

6824738 -0.89337 0.006862 Prmt5 protein arginine N-methyltransferase 5 NM_013768 (Prmt5), mRNA. 6839607 -0.89349 0.001748 Abcc1 ATP-binding cassette, sub-family C NM_008576 (CFTR/MRP), member 1 (Abcc1), mRNA.

6960147 -0.89352 0.00102 Etfb electron transferring flavoprotein, beta NM_026695 polypeptide (Etfb), mRNA. 6770013 -0.89425 0.003443 Eea1 early endosome antigen 1 (Eea1), mRNA. NM_001001932

6792822 -0.89459 0.00074 Fasn fatty acid synthase (Fasn), mRNA. NM_007988 6924832 -0.89576 0.002147 Plk3 polo-like kinase 3 (Drosophila) (Plk3), NM_013807 mRNA. 6806618 -0.89603 0.001312 Nol7 nucleolar protein 7 (Nol7), mRNA. NM_023554 6942192 -0.89607 0.000667 Gusb glucuronidase, beta (Gusb), mRNA. NM_010368 6868899 -0.8963 0.001286 Vldlr very low density lipoprotein receptor (Vldlr), NM_013703 transcript variant 1, mRNA. 6864520 -0.89652 0.001531 Brd8 bromodomain containing 8 (Brd8), mRNA. NM_030147

6782248 -0.89704 0.006241 Mybbp1a MYB binding protein (P160) 1a (Mybbp1a), NM_016776 mRNA. 6917039 -0.89716 0.000536 Sf3a3 splicing factor 3a, subunit 3 (Sf3a3), NM_029157 mRNA. 6917810 -0.89767 0.005055 E2f2 E2F transcription factor 2 (E2f2), mRNA. NM_177733 6872651 -0.89806 0.001129 Sgms1 sphingomyelin synthase 1 (Sgms1), NM_001168525 transcript variant 1, mRNA. 6844187 -0.89815 7.9E-05 2310008H04Ri RIKEN cDNA 2310008H04 gene NM_146068 k (2310008H04Rik), mRNA. 6782697 -0.89844 0.001344 Unc119 unc-119 homolog (C. elegans) (Unc119), NM_011676 mRNA. 6966939 -0.89866 0.00043 Flt3l FMS-like tyrosine kinase 3 ligand (Flt3l), NM_013520 mRNA. 6839230 -0.89876 0.000201 BC024814 cDNA sequence BC024814, mRNA (cDNA BC024814 clone MGC:38788 IMAGE:5359405), complete cds. 6977761 -0.89936 0.000631 Gadd45gip1 growth arrest and DNA-damage-inducible, NM_183358 gamma interacting protein 1 (Gadd45gip1), mRNA. 6769735 -0.89938 0.006725 Uhrf1bp1l UHRF1 (ICBP90) binding protein 1-like NM_029166 (Uhrf1bp1l), mRNA. 6951096 -0.89986 0.000829 Med21 mediator complex subunit 21 (Med21), NM_025315 mRNA. 6823068 -0.90158 0.002614 Anxa7 annexin A7 (Anxa7), transcript variant 1, NM_009674 mRNA. 6805366 -0.90178 0.000881 Hist1h4d // histone cluster 1, H4d (Hist1h4d), mRNA. NM_175654 Hist1h4d 6859972 -0.90186 0.001477 Egr1 early growth response 1 (Egr1), mRNA. NM_007913 6985009 -0.90195 0.000419 Ddx28 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_028038 28 (Ddx28), nuclear gene encoding mitochondrial protein, mRNA. 6755729 -0.90377 0.004427 Cnih4 cornichon homolog 4 (Drosophila) (Cnih4), NM_030131 mRNA. 6772713 -0.90439 0.001582 Tbpl1 TATA box binding protein-like 1 (Tbpl1), NM_011603 mRNA. 6987244 -0.90535 0.009529 Chordc1 cysteine and histidine-rich domain NM_025844 (CHORD)-containing, zinc-binding protein 1 (Chordc1), mRNA. 6781032 -0.9066 0.000861 Rapgef6 Rap guanine nucleotide exchange factor NM_175258 (GEF) 6 (Rapgef6), mRNA. 6771052 -0.90668 0.002031 Ifng interferon gamma (Ifng), mRNA. NM_008337 6968643 -0.90686 3.99E-05 Ntrk3 neurotrophic tyrosine kinase, receptor, type NM_008746 3 (Ntrk3), transcript variant 1, mRNA.

6961895 -0.90715 0.00018 Aen apoptosis enhancing nuclease (Aen), NM_026531 transcript variant 1, mRNA. 6752884 -0.90717 0.000464 R3hdm1 R3H domain 1 (binds single-stranded NM_181750 nucleic acids) (R3hdm1), mRNA. 6765719 -0.90728 0.001226 Nup43 nucleoporin 43 (Nup43), mRNA. NM_145706 7011264 -0.90754 0.005989 Hprt hypoxanthine guanine phosphoribosyl NM_013556 transferase (Hprt), mRNA. 6941897 -0.90758 0.0017 Eif2b1 eukaryotic translation initiation factor 2B, NM_145371 subunit 1 (alpha) (Eif2b1), mRNA. 6802433 -0.90814 0.000116 0610007P14Ri RIKEN cDNA 0610007P14 gene NM_021446 k (0610007P14Rik), mRNA. 6751634 -0.90817 0.005931 Gpc1 glypican 1 (Gpc1), mRNA. NM_016696 6962054 -0.90847 0.000106 Pde8a phosphodiesterase 8A (Pde8a), mRNA. NM_008803 6792554 -0.90854 0.000111 Srsf2 serine/arginine-rich splicing factor 2 NM_011358 (Srsf2), mRNA. 6893279 -0.90898 0.000325 Nfatc2 nuclear factor of activated T-cells, NM_001136073 cytoplasmic, calcineurin-dependent 2 (Nfatc2), transcript variant d, mRNA. 6935043 -0.90914 9.46E-06 Plod3 procollagen-lysine, 2-oxoglutarate 5- NM_011962 dioxygenase 3 (Plod3), mRNA. 6788120 -0.90932 0.000904 Hnrnpab heterogeneous nuclear ribonucleoprotein NM_001048061 A/B (Hnrnpab), transcript variant 1, mRNA.

6815853 -0.90942 0.000295 Zswim6 zinc finger, SWIM domain containing 6 NM_145456 (Zswim6), mRNA. 6836839 -0.9095 4.29E-05 Slc39a4 solute carrier family 39 (zinc transporter), NM_028064 member 4 (Slc39a4), mRNA.

6806078 -0.90986 0.003402 Ripk1 receptor (TNFRSF)-interacting serine- NM_009068 threonine kinase 1 (Ripk1), mRNA. 6918801 -0.90987 0.001029 Lzic leucine zipper and CTNNBIP1 domain NM_026963 containing (Lzic), mRNA. 6976821 -0.90988 0.000345 Nat2 N-acetyltransferase 2 (arylamine N- NM_010874 acetyltransferase) (Nat2), transcript variant 1, mRNA. 6971410 -0.91105 0.000389 Prss53 protease, serine, 53 (Prss53), mRNA. NM_001081268 6888937 -0.91212 0.001417 Hsd17b12 hydroxysteroid (17-beta) dehydrogenase NM_019657 12 (Hsd17b12), mRNA. 6920960 -0.91221 0.001362 Topors topoisomerase I binding, arginine/serine- NM_134097 rich (Topors), mRNA. 6843343 -0.91222 0.002178 Chaf1b chromatin assembly factor 1, subunit B NM_028083 (p60) (Chaf1b), mRNA. 6988603 -0.91279 0.001636 Thy1 thymus cell antigen 1, theta (Thy1), mRNA. NM_009382

6953051 -0.91279 0.000465 E330009J07Ri RIKEN cDNA E330009J07 gene NM_175528 k (E330009J07Rik), mRNA. 6870429 -0.91335 0.000101 Mxi1 Max interacting protein 1 (Mxi1), transcript NM_001008542 variant 2, mRNA. 6801499 -0.91388 0.002165 Sav1 salvador homolog 1 (Drosophila) (Sav1), NM_022028 mRNA. 6941762 -0.91389 0.000775 Anapc5 anaphase-promoting complex subunit 5 NM_021505 (Anapc5), transcript variant 1, mRNA. 6955604 -0.91433 0.000245 Mrps25 mitochondrial ribosomal protein S25 NM_025578 (Mrps25), nuclear gene encoding mitochondrial protein, mRNA. 6850786 -0.91449 0.003752 Ccnd3 cyclin D3 (Ccnd3), transcript variant 3, NM_001081636 mRNA. 6861880 -0.91479 0.002693 Stard6 StAR-related lipid transfer (START) NM_029019 domain containing 6 (Stard6), mRNA. 6912885 -0.91479 0.000414 Chmp5 chromatin modifying protein 5 (Chmp5), NM_029814 mRNA. 6954613 -0.91509 0.004145 Rnf181 ring finger protein 181 (Rnf181), mRNA. NM_025607 6784241 -0.9161 0.00091 Mlx MAX-like protein X (Mlx), transcript variant NM_011550 3, mRNA. 6753710 -0.91719 0.004532 Uchl5 ubiquitin carboxyl-terminal esterase L5 NM_019562 (Uchl5), transcript variant 1, mRNA. 4311853 -0.91728 0.000622 --- AFFX-r2-Bs-phe-5_st, polya_spike --- 6766372 -0.91798 0.000166 Mtap7 microtubule-associated protein 7 (Mtap7), NM_008635 transcript variant 1, mRNA. 6780895 -0.91798 4.12E-05 Cdkl3 cyclin-dependent kinase-like 3 (Cdkl3), NM_001166654 transcript variant 3, mRNA. 6975247 -0.91881 0.000998 Gtf2e2 general transcription factor II E, NM_001167922 polypeptide 2 (beta subunit) (Gtf2e2), transcript variant 1, mRNA. 6812263 -0.91916 0.000722 Peci peroxisomal delta3, delta2-enoyl- NM_011868 Coenzyme A isomerase (Peci), transcript variant 2, mRNA. 7018756 -0.91988 0.003481 Magt1 magnesium transporter 1 (Magt1), NM_001190409 transcript variant 1, mRNA. 6784345 -0.92086 0.001152 Grn granulin (Grn), mRNA. NM_008175 6854509 -0.9212 0.000238 Cuta cutA divalent cation tolerance homolog (E. NM_026307 coli) (Cuta), transcript variant 1, mRNA.

7020765 -0.92136 0.000176 Rab9 RAB9, member RAS oncogene family NM_019773 (Rab9), mRNA. 6881340 -0.92167 4.77E-06 Mcm8 minichromosome maintenance deficient 8 NM_025676 (S. cerevisiae) (Mcm8), mRNA. 6946948 -0.92247 0.004011 Immt inner membrane protein, mitochondrial NM_029673 (Immt), nuclear gene encoding mitochondrial protein, mRNA. 6946511 -0.92266 7.46E-05 Lancl2 LanC (bacterial lantibiotic synthetase NM_133737 component C)-like 2 (Lancl2), mRNA. 6795599 -0.92273 0.000621 Fancm Fanconi anemia, complementation group NM_178912 M (Fancm), mRNA. 6935496 -0.92282 0.003463 Bud31 BUD31 homolog (yeast) (Bud31), mRNA. NM_001008705

6900713 -0.92297 0.002285 Sass6 spindle assembly 6 homolog (C. elegans) NM_028349 (Sass6), mRNA. 6850831 -0.92329 0.000581 B430306N03Ri CRKD-binding protein (Crkr) mRNA, AY522648 k complete cds. 6890288 -0.92435 5.17E-05 Ehd4 EH-domain containing 4 (Ehd4), mRNA. NM_133838 6983822 -0.92482 0.001377 Dcaf15 DDB1 and CUL4 associated factor 15 NM_172502 (Dcaf15), mRNA. 6813740 -0.92521 1.41E-06 4930486L24Ri RIKEN cDNA 4930486L24 gene NM_178098 k (4930486L24Rik), mRNA. 6791174 -0.92631 4.15E-07 Tbkbp1 TBK1 binding protein 1 (Tbkbp1), mRNA. NM_198100

6894152 -0.92828 0.000823 Psma7 proteasome (prosome, macropain) subunit, NM_011969 alpha type 7 (Psma7), mRNA. 6863299 -0.92833 0.001937 Usp14 ubiquitin specific peptidase 14 (Usp14), NM_021522 transcript variant 1, mRNA. 6969922 -0.92915 0.003371 Rhog ras homolog gene family, member G NM_019566 (Rhog), mRNA. 7018524 -0.93031 0.000343 Slc7a3 solute carrier family 7 (cationic amino acid NM_007515 transporter, y+ system), member 3 (Slc7a3), mRNA. 6987132 -0.93096 0.006246 Taf1d TATA box binding protein (Tbp)-associated NR_028401 factor, RNA polymerase I, D (Taf1d), transcript variant 1, non-coding RNA.

6779688 -0.93187 0.003642 Pnpt1 polyribonucleotide nucleotidyltransferase 1 NM_027869 (Pnpt1), mRNA. 6764351 -0.93243 0.001767 Fh1 fumarate hydratase 1 (Fh1), mRNA. NM_010209 6972227 -0.93256 0.001553 Chid1 chitinase domain containing 1 (Chid1), NM_001142681 transcript variant 1, mRNA. 6803321 -0.93265 0.000163 4831426I19Rik RIKEN cDNA 4831426I19 gene NM_001042699 (4831426I19Rik), transcript variant 1, mRNA. 6906834 -0.93288 5.04E-05 Zbtb7b zinc finger and BTB domain containing 7B NM_009565 (Zbtb7b), mRNA. 6959236 -0.93296 0.000954 Tgfb1 transforming growth factor, beta 1 (Tgfb1), NM_011577 mRNA. 6792485 -0.93312 0.000213 Galk1 galactokinase 1 (Galk1), mRNA. NM_016905 6843653 -0.93354 0.003651 Coro7 coronin 7 (Coro7), mRNA. NM_030205 6972882 -0.93392 0.002411 Prpf31 PRP31 pre-mRNA processing factor 31 NM_027328 homolog (yeast) (Prpf31), transcript variant 1, mRNA. 6768897 -0.9341 0.001787 Chchd10 coiled-coil-helix-coiled-coil-helix domain NM_175329 containing 10 (Chchd10), mRNA. 6853248 -0.9347 0.000606 Tfb1m transcription factor B1, mitochondrial NM_146074 (Tfb1m), nuclear gene encoding mitochondrial protein, mRNA. 6971345 -0.93526 8.56E-05 Sephs2 selenophosphate synthetase 2 (Sephs2), NM_009266 mRNA. 6878730 -0.93543 0.000865 Ssrp1 structure specific recognition protein 1 NM_001136081 (Ssrp1), transcript variant 2, mRNA. 6947760 -0.93544 0.006347 Rpn1 ribophorin I (Rpn1), mRNA. NM_133933 6788264 -0.93555 0.000217 Hspa4 heat shock protein 4 (Hspa4), mRNA. NM_008300 6910708 -0.93567 0.009027 Rabggtb RAB geranylgeranyl transferase, b subunit NR_028095 (Rabggtb), transcript variant 5, non-coding RNA. 6924892 -0.93694 0.000582 Cdc20 cell division cycle 20 homolog (S. NM_023223 cerevisiae) (Cdc20), mRNA. 6956902 -0.93747 2.3E-06 Cacna1c calcium channel, voltage-dependent, L NM_001159533 type, alpha 1C subunit (Cacna1c), transcript variant 2, mRNA. 6915889 -0.93806 0.001155 Mier1 mesoderm induction early response 1 NM_027696 homolog (Xenopus laevis (Mier1), transcript variant 1, mRNA. 6784236 -0.93832 0.002547 Atp6v0a1 ATPase, H+ transporting, lysosomal V0 NM_016920 subunit A1 (Atp6v0a1), mRNA. 6956950 -0.93864 1.78E-05 Ccdc77 coiled-coil domain containing 77 (Ccdc77), NM_026028 mRNA. 6884352 -0.93966 0.000556 Hspa14 heat shock protein 14 (Hspa14), transcript NM_015765 variant 1, mRNA. 7010707 -0.94014 0.001056 Rnf113a1 ring finger protein 113A1 (Rnf113a1), NM_153503 mRNA. 6865709 -0.94037 4.02E-07 Aldh7a1 aldehyde dehydrogenase family 7, member NM_001127338 A1 (Aldh7a1), transcript variant 2, mRNA.

6841399 -0.94043 0.001358 Ift57 intraflagellar transport 57 homolog NM_028680 (Chlamydomonas) (Ift57), mRNA. 6983879 -0.9405 0.000103 Calr calreticulin (Calr), mRNA. NM_007591 6917078 -0.94121 0.003608 Meaf6 MYST/Esa1-associated factor 6 (Meaf6), NM_027310 mRNA. 6837328 -0.94125 9.22E-05 Pmm1 phosphomannomutase 1 (Pmm1), mRNA. NM_013872

6893630 -0.94171 0.004381 Ctsz cathepsin Z (Ctsz), mRNA. NM_022325 6985991 -0.94329 8.67E-06 Fanca Fanconi anemia, complementation group A NM_016925 (Fanca), mRNA. 6783242 -0.94357 0.000173 4632419I22Rik RIKEN cDNA 4632419I22 gene, mRNA BC067002 (cDNA clone MGC:91302 IMAGE:5716200), complete cds. 6963364 -0.94428 0.000705 Rpl27a ribosomal protein L27A (Rpl27a), mRNA. NM_011975

6811073 -0.9449 0.000137 Edaradd EDAR (ectodysplasin-A receptor)- NM_133643 associated death domain (Edaradd), transcript variant 1, mRNA. 6934902 -0.94592 9.83E-05 Tbl2 transducin (beta)-like 2 (Tbl2), mRNA. NM_013763 6976190 -0.94593 0.001033 Aga aspartylglucosaminidase (Aga), mRNA. NM_001005847 6824007 -0.94688 0.006414 Ghitm growth hormone inducible transmembrane NM_078478 protein (Ghitm), mRNA. 6766301 -0.94763 0.001513 Perp PERP, TP53 apoptosis effector (Perp), NM_022032 mRNA. 6972178 -0.94782 0.001188 Rnh1 ribonuclease/angiogenin inhibitor 1 (Rnh1), NM_001172100 transcript variant 2, mRNA. 6868519 -0.94803 0.005732 D030056L22Ri RIKEN cDNA D030056L22 gene, mRNA BC020125 k (cDNA clone MGC:28164 IMAGE:3985075), complete cds. 6778055 -0.94874 0.001925 Cdk2 cyclin-dependent kinase 2 (Cdk2), NM_183417 transcript variant 1, mRNA. 6872203 -0.9489 0.001259 Smc5 structural maintenance of chromosomes 5 NM_153808 (Smc5), mRNA. 6966314 -0.9497 0.000382 Ffar2 free fatty acid receptor 2 (Ffar2), transcript NM_146187 variant 1, mRNA. 6901055 -0.95022 4.56E-05 Sec24d Sec24 related gene family, member D (S. NM_027135 cerevisiae) (Sec24d), mRNA. 6850021 -0.95105 0.002639 Psmb8 proteasome (prosome, macropain) subunit, NM_010724 beta type 8 (large multifunctional peptidase 7) (Psmb8), mRNA.

6960375 -0.95127 0.000123 Gys1 glycogen synthase 1, muscle (Gys1), NM_030678 mRNA. 6761998 -0.95311 5.09E-07 Zranb3 zinc finger, RAN-binding domain containing NM_027678 3 (Zranb3), mRNA. 6999449 -0.95345 0.001274 Csrnp1 cysteine-serine-rich nuclear protein 1 NM_153287 (Csrnp1), mRNA. 6782214 -0.95383 4.89E-05 Fam64a family with sequence similarity 64, member NM_144526 A (Fam64a), mRNA. 6828663 -0.9545 2.12E-05 Capsl calcyphosine-like (Capsl), mRNA. NM_029341 6781240 -0.95452 0.000817 Larp1 La ribonucleoprotein domain family, NM_028451 member 1 (Larp1), mRNA. 6771141 -0.9554 0.000173 Llph LLP homolog, long-term synaptic NM_025431 facilitation (Aplysia) (Llph), mRNA. 6855981 -0.95551 0.000789 Satb1 special AT-rich sequence binding protein 1 NM_009122 (Satb1), transcript variant 2, mRNA. 6947404 -0.95665 0.006022 Bola3 bolA-like 3 (E. coli) (Bola3), mRNA. NM_175277 6855003 -0.95695 9.25E-05 Slc39a7 solute carrier family 39 (zinc transporter), NM_008202 member 7 (Slc39a7), transcript variant 1, mRNA. 6810371 -0.95831 0.002607 Arl15 ADP-ribosylation factor-like 15 (Arl15), NM_172595 mRNA. 6800228 -0.95893 0.000125 Arl4a ADP-ribosylation factor-like 4A (Arl4a), NM_001039515 transcript variant 2, mRNA. 6818556 -0.95894 0.002675 Psmc6 proteasome (prosome, macropain) 26S NM_025959 subunit, ATPase, 6 (Psmc6), mRNA. 6985343 -0.95938 0.005602 Ddx19b DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_172284 19b (Ddx19b), transcript variant 2, mRNA.

7009947 -0.96011 0.000392 Mid1ip1 Mid1 interacting protein 1 (gastrulation NM_001166635 specific G12-like (zebrafish)) (Mid1ip1), transcript variant 1, mRNA. 7005505 -0.96027 0.000899 H2-T22 histocompatibility 2, T region locus 22 (H2- NM_010397 T22), mRNA. 7013981 -0.96057 0.001267 2900062L11Ri RIKEN cDNA 2900062L11 gene NM_029823 k (2900062L11Rik), mRNA. 6872063 -0.96081 0.007383 1110059E24Ri RIKEN cDNA 1110059E24 gene, mRNA BC023385 k (cDNA clone MGC:30990 IMAGE:5253886), complete cds. 6749736 -0.96094 0.001318 Casp8 caspase 8 (Casp8), transcript variant 1, NM_009812 mRNA. 6843951 -0.96142 0.001674 Rsl1d1 ribosomal L1 domain containing 1 NM_025546 (Rsl1d1), mRNA. 6825553 -0.9618 3.31E-08 Dock5 dedicator of cytokinesis 5 (Dock5), mRNA. NM_177780

6983869 -0.962 0.002252 Nacc1 nucleus accumbens associated 1, BEN NM_025788 and BTB (POZ) domain containing (Nacc1), mRNA. 6874563 -0.96335 0.005154 Fam107b family with sequence similarity 107, BC021353 member B, mRNA (cDNA clone MGC:29309 IMAGE:5006672), complete cds. 6849891 -0.96366 2.82E-06 Cyp4f40 cytochrome P450, family 4, subfamily f, NM_001101588 polypeptide 40 (Cyp4f40), mRNA. 6895959 -0.96562 0.003204 Mtfr1 mitochondrial fission regulator 1 (Mtfr1), NM_026182 nuclear gene encoding mitochondrial protein, mRNA. 6896591 -0.96592 0.000999 Zfp639 zinc finger protein 639 (Zfp639), transcript NM_144519 variant 1, mRNA. 6819596 -0.96604 0.003738 Sacs Isoform 3 of Sacsin ENSMUST00000119943 gene:ENSMUSG00000048279 6817616 -0.96618 0.00149 4931406H21Ri RIKEN cDNA 4931406H21 gene NR_033492 k (4931406H21Rik), non-coding RNA. 6767155 -0.96699 0.001346 Hdac2 histone deacetylase 2 (Hdac2), mRNA. NM_008229 6817944 -0.96702 5.04E-05 Sfmbt1 Scm-like with four mbt domains 1 NM_001166531 (Sfmbt1), transcript variant 2, mRNA. 6753085 -0.96742 0.000125 Nucks1 nuclear casein kinase and cyclin- NM_175294 dependent kinase substrate 1 (Nucks1), transcript variant 1, mRNA. 6949853 -0.96745 0.000343 Mrpl51 mitochondrial ribosomal protein L51 NM_025595 (Mrpl51), nuclear gene encoding mitochondrial protein, mRNA. 6982786 -0.96832 0.001821 Clcn3 chloride channel 3 (Clcn3), transcript NM_173874 variant e, mRNA. 6940363 -0.96971 5.03E-06 Hpse heparanase (Hpse), mRNA. NM_152803 6844362 -0.97002 0.006163 Mrpl40 mitochondrial ribosomal protein L40 NM_010922 (Mrpl40), nuclear gene encoding mitochondrial protein, mRNA. 6993153 -0.97003 0.000899 Ccr2 chemokine (C-C motif) receptor 2 (Ccr2), NM_009915 mRNA. 6849785 -0.9714 1.32E-06 Ndufv3 NADH dehydrogenase (ubiquinone) NM_030087 flavoprotein 3 (Ndufv3), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6785675 -0.97152 0.000243 Nf2 neurofibromatosis 2 (Nf2), mRNA. NM_010898 6840086 -0.97252 0.003392 Dnajb11 DnaJ (Hsp40) homolog, subfamily B, NM_001190804 member 11 (Dnajb11), transcript variant 2, mRNA. 6981113 -0.97256 0.004966 Plekha2 pleckstrin homology domain-containing, NM_031257 family A (phosphoinositide binding specific) member 2 (Plekha2), mRNA. 6963003 -0.9727 3.67E-05 Stard10 START domain containing 10 (Stard10), NM_019990 mRNA. 6812212 -0.97274 0.002839 Serpinb6a serine (or cysteine) peptidase inhibitor, NM_001164118 clade B, member 6a (Serpinb6a), transcript variant 3, mRNA. 6824553 -0.97279 0.00014 Tep1 telomerase associated protein 1 (Tep1), NM_009351 mRNA. 6943204 -0.97348 0.000733 Ubl3 ubiquitin-like 3 (Ubl3), mRNA. NM_011908 6977687 -0.97374 0.001204 Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide NM_197982 39 (Ddx39), mRNA. 6972993 -0.97391 0.003301 Chmp2a chromatin modifying protein 2A (Chmp2a), NM_026885 mRNA. 6770445 -0.97435 0.00296 Ccdc59 coiled-coil domain containing 59 (Ccdc59), NM_025602 mRNA. 6987084 -0.9746 0.007265 Cwc15 CWC15 homolog (S. cerevisiae) (Cwc15), NM_023153 mRNA. 6819883 -0.9768 0.00037 Pbk PDZ binding kinase (Pbk), mRNA. NM_023209 6958983 -0.97765 9.3E-09 Dmwd dystrophia myotonica-containing WD NM_010058 repeat motif (Dmwd), mRNA. 6958904 -0.9779 0.000711 Ap2s1 adaptor-related protein complex 2, sigma 1 NM_198613 subunit (Ap2s1), mRNA. 6812518 -0.97808 0.000677 Eef1e1 eukaryotic translation elongation factor 1 NM_025380 epsilon 1 (Eef1e1), mRNA. 6758663 -0.97846 0.000181 Asnsd1 asparagine synthetase domain containing NM_133728 1 (Asnsd1), mRNA. 6762429 -0.97861 0.00376 Nav1 neuron navigator 1 (Nav1), mRNA. NM_173437 6899359 -0.9795 0.000187 S100a13 S100 calcium binding protein A13 NM_009113 (S100a13), mRNA. 6850017 -0.97995 6.15E-05 H2-DMb2 histocompatibility 2, class II, locus Mb2 (H2- NM_010388 DMb2), mRNA. 6763894 -0.98019 0.000127 Uck2 uridine-cytidine kinase 2 (Uck2), mRNA. NM_030724 6970066 -0.98085 0.000629 Trim30d tripartite motif-containing 30D (Trim30d), NM_199146 transcript variant 1, mRNA. 6835104 -0.9812 0.000573 Azin1 antizyme inhibitor 1 (Azin1), transcript NM_001102458 variant 1, mRNA. 6849435 -0.98138 0.001024 Rgs11 regulator of G-protein signaling 11 NM_001081069 (Rgs11), mRNA. 6807154 -0.98206 8.57E-05 Sfxn1 sideroflexin 1 (Sfxn1), mRNA. NM_027324 6957263 -0.98251 0.000356 Ccnd2 cyclin D2 (Ccnd2), mRNA. NM_009829 6849845 -0.98339 0.000208 Rrp1b ribosomal RNA processing 1 homolog B NM_028244 (S. cerevisiae) (Rrp1b), transcript variant 1, mRNA. 6961917 -0.98405 6.2E-06 Fanci Fanconi anemia, complementation group I NM_145946 (Fanci), mRNA. 6837428 -0.98508 0.00013 Cyb5r3 cytochrome b5 reductase 3 (Cyb5r3), NM_029787 mRNA. 6833418 -0.9858 0.000124 Prr13 proline rich 13 (Prr13), transcript variant 1, NM_025385 mRNA. 6958905 -0.98594 0.001245 Slc1a5 solute carrier family 1 (neutral amino acid NM_009201 transporter), member 5 (Slc1a5), mRNA.

6765153 -0.98636 7.71E-06 Smyd2 SET and MYND domain containing 2 NM_026796 (Smyd2), mRNA. 6849221 -0.98674 2.77E-05 Pkmyt1 protein kinase, membrane associated NM_023058 tyrosine/threonine 1 (Pkmyt1), mRNA. 6790585 -0.98694 0.001281 Dynll2 dynein light chain LC8-type 2 (Dynll2), NM_026556 transcript variant 1, mRNA. 6939661 -0.9874 0.000133 Cenpc1 centromere protein C1 (Cenpc1), mRNA. NM_007683 6955228 -0.98748 0.00015 Anxa4 annexin A4 (Anxa4), mRNA. NM_013471 6899029 -0.98758 0.001349 Mrpl24 mitochondrial ribosomal protein L24 NM_026591 (Mrpl24), nuclear gene encoding mitochondrial protein, mRNA. 6832530 -0.98786 0.000132 Creld2 cysteine-rich with EGF-like domains 2 NM_029720 (Creld2), mRNA. 6863973 -0.98846 0.000328 Slc39a6 solute carrier family 39 (metal ion NM_139143 transporter), member 6 (Slc39a6), mRNA.

6959305 -0.98909 0.003099 Sertad1 SERTA domain containing 1 (Sertad1), NM_018820 mRNA. 6860259 -0.99005 0.000149 Arhgap26 Rho GTPase activating protein 26 NM_175164 (Arhgap26), mRNA. 6926936 -0.99011 0.000837 Pgd phosphogluconate dehydrogenase (Pgd), NM_001081274 mRNA. 6947558 -0.99027 2.57E-05 Alms1 Alstrom syndrome 1 homolog (human) NM_145223 (Alms1), mRNA. 6762132 -0.99091 0.002575 Mapkapk2 MAP kinase-activated protein kinase 2 NM_008551 (Mapkapk2), mRNA. 6857435 -0.99156 0.001305 Eif2ak2 eukaryotic translation initiation factor 2- NM_011163 alpha kinase 2 (Eif2ak2), mRNA. 6942474 -0.99162 4.52E-06 Srcrb4d scavenger receptor cysteine rich domain NM_001160366 containing, group B (4 domains) (Srcrb4d), mRNA. 6854347 -0.99183 0.000117 Ccnf cyclin F (Ccnf), mRNA. NM_007634 6924027 -0.99201 0.00137 Slc35d1 solute carrier family 35 (UDP-glucuronic NM_177732 acid/UDP-N-acetylgalactosamine dual transporter), member D1 (Slc35d1), mRNA. 6797544 -0.99233 0.00023 Ifi27l1 interferon, alpha-inducible protein 27 like 1 NM_026790 (Ifi27l1), transcript variant 1, mRNA. 6833223 -0.99282 0.000142 Atf1 activating transcription factor 1 (Atf1), NM_007497 mRNA. 6888898 -0.9944 0.000427 Cd82 CD82 antigen (Cd82), transcript variant 1, NM_007656 mRNA. 6990527 -0.99465 0.000302 Myo5a myosin VA (Myo5a), mRNA. NM_010864 6964163 -0.99475 0.000848 Il21r interleukin 21 receptor (Il21r), mRNA. NM_021887 6778976 -0.99502 5.02E-06 Fbxo48 F-box protein 48 (Fbxo48), mRNA. NM_176982 7016797 -0.9951 0.00621 Rap2c RAP2C, member of RAS oncogene family NM_172413 (Rap2c), mRNA. 6965593 -0.99532 0.000282 Sepw1 selenoprotein W, muscle 1 (Sepw1), NM_009156 mRNA. 6802732 -0.99576 0.001306 4930534B04Ri RIKEN cDNA 4930534B04 gene NM_181815 k (4930534B04Rik), mRNA. 6806673 -0.99634 0.000248 Jarid2 jumonji, AT rich interactive domain 2 NM_021878 (Jarid2), mRNA. 6968871 -0.99653 0.000777 Hdgfrp3 hepatoma-derived growth factor, related NM_013886 protein 3 (Hdgfrp3), mRNA. 6784829 -0.99687 3.02E-05 Map2k6 mitogen-activated protein kinase kinase 6 NM_011943 (Map2k6), mRNA. 6977075 -0.99853 0.003725 Dda1 DET1 and DDB1 associated 1 (Dda1), NM_025600 mRNA. 6919208 -0.99872 0.000821 Sdf4 stromal cell derived factor 4 (Sdf4), mRNA. NM_011341

6832191 -0.99882 0.002092 1500032L24Ri RIKEN cDNA 1500032L24 gene, mRNA BC092006 k (cDNA clone IMAGE:5684373), complete cds. 6912923 -0.99942 1.98E-07 Nudt2 nudix (nucleoside diphosphate linked NM_025539 moiety X)-type motif 2 (Nudt2), mRNA. 6970650 -1.00051 0.003167 Psma1 proteasome (prosome, macropain) subunit, NM_011965 alpha type 1 (Psma1), mRNA. 6926021 -1.00137 1.08E-05 Sepn1 selenoprotein N, 1 (Sepn1), mRNA. NM_029100 6940595 -1.00162 2.11E-05 Hsd17b11 hydroxysteroid (17-beta) dehydrogenase NM_053262 11 (Hsd17b11), mRNA. 6759043 -1.00172 0.008023 Wdr12 WD repeat domain 12 (Wdr12), mRNA. NM_021312 6782776 -1.00492 9.67E-05 Nf1 neurofibromatosis 1 (Nf1), mRNA. NM_010897 6876570 -1.00496 0.000749 Arpc5l actin related protein 2/3 complex, subunit 5- NM_028809 like (Arpc5l), mRNA. 7007282 -1.00565 0.00398 H2-Q6 histocompatibility 2, Q region locus 6 (H2- NM_207648 Q6), mRNA. 6961203 -1.00611 0.000463 H47 histocompatibility 47 (H47), mRNA. NM_024439 6902148 -1.00626 3.42E-05 Odf2l outer dense fiber of sperm tails 2-like NM_001162538 (Odf2l), transcript variant 1, mRNA. 6965620 -1.00637 0.002789 Sae1 SUMO1 activating enzyme subunit 1 NM_019748 (Sae1), mRNA. 6806294 -1.0069 0.003722 Riok1 RIO kinase 1 (yeast) (Riok1), mRNA. NM_024242 6812652 -1.00732 0.005533 Nedd9 neural precursor cell expressed, NM_001111324 developmentally down-regulated gene 9 (Nedd9), transcript variant 1, mRNA. 6822297 -1.00921 0.000895 Clybl citrate lyase beta like (Clybl), mRNA. NM_029556 6916712 -1.00923 0.001246 Elovl1 elongation of very long chain fatty acids NM_019422 (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 (Elovl1), transcript variant 2, mRNA. 6786666 -1.01156 1.25E-05 0610010F05Ri RIKEN cDNA 0610010F05 gene NM_027860 k (0610010F05Rik), mRNA. 6758625 -1.0119 0.001279 Nab1 Ngfi-A binding protein 1 (Nab1), mRNA. NM_008667 6848688 -1.01215 6.17E-05 Agpat4 1-acylglycerol-3-phosphate O- NM_026644 acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) (Agpat4), mRNA. 6817416 -1.01249 0.000178 Vdac2 voltage-dependent anion channel 2 NM_011695 (Vdac2), nuclear gene encoding mitochondrial protein, mRNA. 6849761 -1.01307 0.001285 Dnahc8 dynein, axonemal, heavy chain 8 (Dnahc8), NM_013811 mRNA. 6856480 -1.01325 1.33E-05 Efna5 ephrin A5 (Efna5), transcript variant 1, NM_207654 mRNA. 6844359 -1.01331 0.000108 Cdc45 cell division cycle 45 homolog (S. NM_009862 cerevisiae) (Cdc45), transcript variant 1, mRNA. 6791222 -1.01364 0.001198 Rpl23 ribosomal protein L23 (Rpl23), mRNA. NM_022891 6769357 -1.01366 0.001462 Txnrd1 thioredoxin reductase 1 (Txnrd1), transcript NM_001042523 variant 1, mRNA. 6868649 -1.01422 0.00162 Fam108b family with sequence similarity 108, NM_146096 member B (Fam108b), mRNA. 6822191 -1.01481 0.000494 Ipo5 importin 5 (Ipo5), mRNA. NM_023579 6836646 -1.01634 0.001843 Sf3b4 splicing factor 3b, subunit 4 (Sf3b4), NM_153053 mRNA. 6775310 -1.01662 1.29E-06 Rnf126 ring finger protein 126 (Rnf126), transcript NM_144528 variant 1, mRNA. 6835981 -1.01662 0.00289 Tatdn1 TatD DNase domain containing 1 (Tatdn1), NM_175151 mRNA. 6802387 -1.01743 0.003208 Tmed10 transmembrane emp24-like trafficking NM_026775 protein 10 (yeast) (Tmed10), mRNA. 6784396 -1.01777 0.001016 Nmt1 N-myristoyltransferase 1 (Nmt1), mRNA. NM_008707 6799852 -1.01836 0.000302 Dus4l dihydrouridine synthase 4-like (S. NM_028002 cerevisiae) (Dus4l), mRNA. 6962880 -1.01957 0.00128 Arrb1 arrestin, beta 1 (Arrb1), transcript variant a, NM_177231 mRNA. 6962873 -1.01963 1.51E-05 Mtap6 microtubule-associated protein 6 (Mtap6), NM_001048167 transcript variant 2, mRNA. 6912042 -1.01983 0.000745 Ggh gamma-glutamyl hydrolase (Ggh), mRNA. NM_010281

6758261 -1.02001 5.71E-05 Fhl2 four and a half LIM domains 2 (Fhl2), NM_010212 mRNA. 6978822 -1.02026 0.000188 E2f4 E2F transcription factor 4 (E2f4), mRNA. NM_148952 6762019 -1.0203 0.000133 Dars aspartyl-tRNA synthetase (Dars), transcript NM_177445 variant 1, mRNA. 7011413 -1.02068 0.001236 Cd40lg CD40 ligand (Cd40lg), mRNA. NM_011616 6833972 -1.02079 0.007871 Brix1 BRX1, biogenesis of ribosomes, homolog NM_026396 (S. cerevisiae) (Brix1), mRNA. 6989437 -1.02213 0.003328 Ubl7 ubiquitin-like 7 (bone marrow stromal cell- NM_001122873 derived) (Ubl7), transcript variant 1, mRNA.

6945275 -1.02246 0.001125 Exoc4 exocyst complex component 4 (Exoc4), NM_009148 mRNA. 6935696 -1.0243 0.003236 Uspl1 ubiquitin specific peptidase like 1 (Uspl1), NM_001115153 transcript variant 1, mRNA. 6859779 -1.0252 0.004064 Polr2d polymerase (RNA) II (DNA directed) NM_027002 polypeptide D (Polr2d), transcript variant 1, mRNA. 6985703 -1.0263 0.002053 Mphosph6 M phase phosphoprotein 6 (Mphosph6), NM_026758 mRNA. 6925987 -1.02648 0.005229 Sh3bgrl3 SH3 domain binding glutamic acid-rich NM_080559 protein-like 3 (Sh3bgrl3), mRNA. 6809272 -1.0279 1.05E-06 Enc1 ectodermal-neural cortex 1 (Enc1), mRNA. NM_007930

6768014 -1.02858 5.24E-05 Gja1 gap junction protein, alpha 1 (Gja1), NM_010288 mRNA. 6916143 -1.02886 1.69E-06 Lrp8 low density lipoprotein receptor-related NM_001080926 protein 8, apolipoprotein e receptor (Lrp8), transcript variant 2, mRNA. 6767610 -1.02965 0.000495 Prep prolyl endopeptidase (Prep), mRNA. NM_011156 6792786 -1.0297 0.000171 Pcyt2 phosphate cytidylyltransferase 2, NM_024229 ethanolamine (Pcyt2), mRNA. 6946138 -1.03038 7.87E-05 Mpp6 membrane protein, palmitoylated 6 NM_001164734 (MAGUK p55 subfamily member 6) (Mpp6), transcript variant 1, mRNA. 6772802 -1.03067 7.22E-06 Enpp1 ectonucleotide NM_008813 pyrophosphatase/phosphodiesterase 1 (Enpp1), mRNA. 6860780 -1.03194 4.51E-05 Tnfaip8 tumor necrosis factor, alpha-induced NM_134131 protein 8 (Tnfaip8), transcript variant 1, mRNA. 6813877 -1.03311 8.72E-06 Zfp367 zinc finger protein 367 (Zfp367), mRNA. NM_175494 6860001 -1.03375 0.000784 Ctnna1 catenin (cadherin associated protein), NM_009818 alpha 1 (Ctnna1), mRNA. 6761139 -1.03415 0.000189 Rnf152 ring finger protein 152 (Rnf152), transcript NM_178779 variant 1, mRNA. 6857415 -1.03465 0.001492 Fez2 fasciculation and elongation protein zeta 2 NM_199448 (zygin II) (Fez2), mRNA. 6759459 -1.03614 0.000307 Acadl acyl-Coenzyme A dehydrogenase, long- NM_007381 chain (Acadl), nuclear gene encoding mitochondrial protein, mRNA. 6909871 -1.03774 0.001177 Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 NM_001040690 (Rap1gds1), transcript variant 1, mRNA.

6783063 -1.03794 0.000358 Acaca acetyl-Coenzyme A carboxylase alpha NM_133360 (Acaca), mRNA. 6966985 -1.03801 9.71E-05 Bax BCL2-associated X protein (Bax), mRNA. NM_007527

6759297 -1.03815 0.000495 Klf7 Kruppel-like factor 7 (ubiquitous) (Klf7), NM_033563 mRNA. 6899353 -1.03931 0.000645 Ilf2 interleukin enhancer binding factor 2 (Ilf2), NM_026374 mRNA. 6996727 -1.03994 0.0065 Uba52 ubiquitin A-52 residue ribosomal protein NM_019883 fusion product 1 (Uba52), mRNA. 6874212 -1.0406 0.000191 Eif3a eukaryotic translation initiation factor 3, NM_010123 subunit A (Eif3a), mRNA. 6971316 -1.04086 9.22E-05 Mvp major vault protein (Mvp), mRNA. NM_080638 6771647 -1.04114 0.001497 Cs citrate synthase (Cs), nuclear gene NM_026444 encoding mitochondrial protein, mRNA. 6811140 -1.04135 0.004203 Mrpl32 mitochondrial ribosomal protein L32 NM_029271 (Mrpl32), nuclear gene encoding mitochondrial protein, mRNA. 6988635 -1.04224 6.59E-05 Hyou1 hypoxia up-regulated 1 (Hyou1), mRNA. NM_021395 6905620 -1.04321 0.000375 Ssr3 signal sequence receptor, gamma (Ssr3), NM_026155 mRNA. 6901950 -1.04379 0.009746 Gbp6 guanylate binding protein 6 (Gbp6), mRNA. NM_145545

7014558 -1.04483 0.000101 Smc1a structural maintenance of chromosomes NM_019710 1A (Smc1a), mRNA. 6811762 -1.04523 0.000126 Gmnn geminin (Gmnn), mRNA. NM_020567 6927240 -1.04602 0.0029 Rer1 RER1 retention in endoplasmic reticulum 1 NM_026395 homolog (S. cerevisiae) (Rer1), mRNA.

6778375 -1.04655 8.95E-05 Sf3a1 splicing factor 3a, subunit 1 (Sf3a1), NM_026175 mRNA. 6954935 -1.04778 0.000992 Mrpl19 mitochondrial ribosomal protein L19 NM_026490 (Mrpl19), nuclear gene encoding mitochondrial protein, mRNA. 6754519 -1.04794 0.000379 Gas5 growth arrest specific 5 (Gas5), non-coding NR_002840 RNA. 7014110 -1.04828 6.53E-09 Rnf128 ring finger protein 128 (Rnf128), mRNA. NM_023270 6831869 -1.04868 0.001376 Polr2f polymerase (RNA) II (DNA directed) NM_027231 polypeptide F (Polr2f), mRNA. 6977814 -1.05027 1.43E-05 Gpt2 glutamic pyruvate transaminase (alanine NM_173866 aminotransferase) 2 (Gpt2), mRNA. 6849543 -1.05118 6.44E-05 Rpl10a ribosomal protein L10A (Rpl10a), mRNA. NM_011287

6892180 -1.05304 4.54E-05 Bcl2l1 BCL2-like 1 (Bcl2l1), nuclear gene NM_009743 encoding mitochondrial protein, mRNA. 6789849 -1.05406 0.001457 Ccdc55 coiled-coil domain containing 55 (Ccdc55), NM_001012309 mRNA. 6990398 -1.05698 1.37E-06 Mns1 meiosis-specific nuclear structural protein NM_008613 1 (Mns1), mRNA. 6759613 -1.0574 8.21E-05 Bard1 BRCA1 associated RING domain 1 NM_007525 (Bard1), mRNA. 6954626 -1.05746 0.000562 Mat2a methionine adenosyltransferase II, alpha NM_145569 (Mat2a), mRNA. 6928740 -1.05941 0.009564 Abcb1a ATP-binding cassette, sub-family B NM_011076 (MDR/TAP), member 1A (Abcb1a), mRNA.

4612444 -1.05967 0.003821 --- AFFX-r2-Bs-dap-3_st, polya_spike --- 6866511 -1.06134 9E-06 Poli polymerase (DNA directed), iota (Poli), NM_011972 transcript variant 2, mRNA. 6851191 -1.06365 0.00497 Ebi3 Epstein-Barr virus induced gene 3 (Ebi3), NM_015766 mRNA. 6992487 -1.06438 0.001083 Lrrfip2 leucine rich repeat (in FLII) interacting NM_001164838 protein 2 (Lrrfip2), transcript variant 1, mRNA. 6966983 -1.06455 0.000275 Ruvbl2 RuvB-like protein 2 (Ruvbl2), mRNA. NM_011304 6807652 -1.06494 0.000604 0610007P08Ri RIKEN cDNA 0610007P08 gene NM_001013608 k (0610007P08Rik), transcript variant 1, mRNA. 6913223 -1.06603 9.68E-05 Nans N-acetylneuraminic acid synthase (sialic NM_053179 acid synthase) (Nans), mRNA. 6992414 -1.06667 0.000443 Cdc25a cell division cycle 25 homolog A (S. NM_007658 pombe) (Cdc25a), mRNA. 6884986 -1.06717 9.48E-06 Nebl nebulette (Nebl), mRNA. NM_028757 6850204 -1.06771 5.24E-06 Ppp1r10 protein phosphatase 1, regulatory subunit NM_175934 10 (Ppp1r10), transcript variant 2, mRNA.

6983894 -1.06813 0.002356 Junb Jun-B oncogene (Junb), mRNA. NM_008416 6899052 -1.06824 5.25E-05 Gpatch4 G patch domain containing 4 (Gpatch4), NM_025663 transcript variant 1, mRNA. 6881172 -1.0688 0.002321 Nop56 NOP56 ribonucleoprotein homolog (yeast) NM_024193 (Nop56), mRNA. 6780863 -1.06959 0.00686 Nhp2 NHP2 ribonucleoprotein homolog (yeast) NM_026631 (Nhp2), mRNA. 7015445 -1.06981 4.09E-05 Suv39h1 suppressor of variegation 3-9 homolog 1 NM_011514 (Drosophila) (Suv39h1), mRNA. 6940347 -1.07075 0.000107 Lin54 lin-54 homolog (C. elegans) (Lin54), NM_001115010 transcript variant 1, mRNA. 6844598 -1.07093 0.000286 Rfc4 replication factor C (activator 1) 4 (Rfc4), NM_145480 mRNA. 6847824 -1.07098 0.002453 4932438H23Ri RIKEN cDNA 4932438H23 gene NM_028905 k (4932438H23Rik), transcript variant 1, mRNA. 6907216 -1.0716 0.000473 Prpf3 PRP3 pre-mRNA processing factor 3 NM_027541 homolog (yeast) (Prpf3), mRNA. 6868176 -1.07176 0.002342 Fam111a RIKEN cDNA 4632417K18 gene, mRNA BC038020 (cDNA clone MGC:46762 IMAGE:3599082), complete cds. 6901316 -1.07226 0.000124 Elovl6 ELOVL family member 6, elongation of NM_130450 long chain fatty acids (yeast) (Elovl6), mRNA. 6943448 -1.07376 5.28E-05 Rfc3 replication factor C (activator 1) 3 (Rfc3), NM_027009 mRNA. 6855659 -1.07385 0.000556 Vegfa vascular endothelial growth factor A NM_001025250 (Vegfa), transcript variant 1, mRNA. 6812444 -1.07452 0.003343 Ssr1 signal sequence receptor, alpha (Ssr1), NM_025965 mRNA. 6974490 -1.07516 0.000279 Agpat5 1-acylglycerol-3-phosphate O- NM_026792 acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) (Agpat5), mRNA.

6782177 -1.0754 0.002074 Mis12 MIS12 homolog (yeast) (Mis12), mRNA. NM_025993 6874683 -1.07574 6.34E-05 Nudt5 nudix (nucleoside diphosphate linked NM_016918 moiety X)-type motif 5 (Nudt5), mRNA. 6965668 -1.07607 0.000187 Ppp5c protein phosphatase 5, catalytic subunit NM_011155 (Ppp5c), mRNA. 6811276 -1.07711 0.000771 Rala v-ral simian leukemia viral oncogene NM_019491 homolog A (ras related) (Rala), mRNA. 6936082 -1.07791 0.000534 Dbf4 DBF4 homolog (S. cerevisiae) (Dbf4), NM_013726 transcript variant 1, mRNA. 6753394 -1.07792 1.36E-05 Phlda3 pleckstrin homology-like domain, family A, NM_013750 member 3 (Phlda3), mRNA. 6766839 -1.07806 0.000511 Themis thymocyte selection associated (Themis), NM_178666 mRNA. 6961977 -1.07835 2.35E-05 Sema4b sema domain, immunoglobulin domain NM_013659 (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B (Sema4b), mRNA. 7014557 -1.07868 0.000405 Hsd17b10 hydroxysteroid (17-beta) dehydrogenase NM_016763 10 (Hsd17b10), nuclear gene encoding mitochondrial protein, mRNA. 6857223 -1.07898 0.001789 --- cdna:Genscan GENSCAN00000035602 chromosome:NCBIM37:17:74826182:7485 7576:-1 6879938 -1.08026 2.57E-05 Ccdc34 coiled-coil domain containing 34 (Ccdc34), NM_026613 mRNA. 6780266 -1.08151 6.89E-05 Nudcd2 NudC domain containing 2 (Nudcd2), NM_026023 mRNA. 6769934 -1.08157 0.000184 Ccdc41 coiled-coil domain containing 41 (Ccdc41), NM_029852 mRNA. 6766381 -1.08189 1.88E-05 Fam54a family with sequence similarity 54, member NM_027930 A (Fam54a), mRNA. 6844177 -1.08245 0.003187 Mcm4 minichromosome maintenance deficient 4 NM_008565 homolog (S. cerevisiae) (Mcm4), mRNA.

6805158 -1.08276 0.000703 Elmo1 engulfment and cell motility 1, ced-12 NM_080288 homolog (C. elegans) (Elmo1), transcript variant 1, mRNA. 6792657 -1.08365 0.00411 Lgals3bp lectin, galactoside-binding, soluble, 3 NM_011150 binding protein (Lgals3bp), mRNA. 6773432 -1.08377 5.56E-08 Slc16a10 solute carrier family 16 (monocarboxylic NM_001114332 acid transporters), member 10 (Slc16a10), transcript variant 1, mRNA. 6775559 -1.0849 4.37E-05 Slc41a2 solute carrier family 41, member 2 NM_177388 (Slc41a2), mRNA. 6989294 -1.08521 0.001439 Pstpip1 proline-serine-threonine phosphatase- NM_011193 interacting protein 1 (Pstpip1), mRNA. 6856269 -1.08543 0.000113 Gtf2f1 general transcription factor IIF, polypeptide NM_133801 1 (Gtf2f1), mRNA. 6868048 -1.08565 0.0011 Ddb1 damage specific DNA binding protein 1 NM_015735 (Ddb1), mRNA. 6885039 -1.0868 0.000894 Dnajc1 DnaJ (Hsp40) homolog, subfamily C, NM_007869 member 1 (Dnajc1), transcript variant 1, mRNA. 6972205 -1.08911 2.16E-06 Lrdd leucine-rich and death domain containing NM_022654 (Lrdd), mRNA. 7019867 -1.08917 0.00094 Acsl4 acyl-CoA synthetase long-chain family NM_207625 member 4 (Acsl4), transcript variant 1, mRNA. 6840175 -1.08983 9.77E-05 Lpp LIM domain containing preferred NM_178665 translocation partner in lipoma (Lpp), transcript variant 1, mRNA. 6820325 -1.08987 8.62E-05 Lcp1 lymphocyte cytosolic protein 1 (Lcp1), NM_008879 mRNA. 6866068 -1.09005 0.000557 Txnl1 thioredoxin-like 1 (Txnl1), mRNA. NM_016792 6792553 -1.0908 9.53E-05 Jmjd6 jumonji domain containing 6 (Jmjd6), NM_033398 mRNA. 6946894 -1.09157 0.001138 Eif2ak3 eukaryotic translation initiation factor 2 NM_010121 alpha kinase 3 (Eif2ak3), mRNA. 6789474 -1.09173 0.002552 C1qbp complement component 1, q NM_007573 subcomponent binding protein (C1qbp), nuclear gene encoding mitochondrial protein, mRNA. 6966990 -1.09255 4.19E-05 Nucb1 nucleobindin 1 (Nucb1), transcript variant NM_001163662 1, mRNA. 6864709 -1.09283 0.00035 Hars histidyl-tRNA synthetase (Hars), mRNA. NM_008214 6952926 -1.09302 0.000927 Parp12 poly (ADP-ribose) polymerase family, NM_172893 member 12 (Parp12), mRNA. 6763682 -1.09328 1.29E-05 Scyl3 SCY1-like 3 (S. cerevisiae) (Scyl3), mRNA. NM_028776

6776104 -1.09598 0.00069 Metap2 methionine aminopeptidase 2 (Metap2), NM_019648 mRNA. 6987422 -1.09618 0.000278 Prkcsh protein kinase C substrate 80K-H (Prkcsh), NM_008925 mRNA. 6870025 -1.09641 0.000177 Pprc1 peroxisome proliferative activated receptor, NM_001081214 gamma, coactivator-related 1 (Pprc1), mRNA. 6891648 -1.09671 0.000145 Rrbp1 ribosome binding protein 1 (Rrbp1), NM_024281 transcript variant 1, mRNA. 6877428 -1.09727 0.000106 Pkp4 plakophilin 4 (Pkp4), transcript variant 1, NM_026361 mRNA. 6776667 -1.09749 2.33E-05 Tmtc2 transmembrane and tetratricopeptide NM_177368 repeat containing 2 (Tmtc2), mRNA. 6909430 -1.09893 8.33E-05 Hadh hydroxyacyl-Coenzyme A dehydrogenase NM_008212 (Hadh), nuclear gene encoding mitochondrial protein, mRNA. 6862751 -1.09901 0.003204 Cyb5 cytochrome b-5 (Cyb5), mRNA. NM_025797 6906749 -1.10166 0.001043 Sema4a sema domain, immunoglobulin domain NM_013658 (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a), transcript variant 1, mRNA.

6771920 -1.10171 8.24E-05 Mthfd1l methylenetetrahydrofolate dehydrogenase NM_172308 (NADP+ dependent) 1-like (Mthfd1l), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.

6757120 -1.10334 5.02E-08 Stau2 staufen (RNA binding protein) homolog 2 NM_025303 (Drosophila) (Stau2), transcript variant 3, mRNA. 6861576 -1.10452 4.8E-05 Nedd4l neural precursor cell expressed, NM_031881 developmentally down-regulated gene 4- like (Nedd4l), transcript variant 2, mRNA.

6964253 -1.10504 4.51E-05 Hirip3 HIRA interacting protein 3 (Hirip3), mRNA. NM_172746

6749773 -1.10543 0.004342 Nop58 NOP58 ribonucleoprotein homolog (yeast) NM_018868 (Nop58), mRNA. 6934308 -1.10602 4.49E-06 Setd8 SET domain containing (lysine NM_030241 methyltransferase) 8 (Setd8), mRNA. 6878709 -1.10676 0.001603 Ube2l6 ubiquitin-conjugating enzyme E2L 6 NM_019949 (Ube2l6), mRNA. 6876342 -1.107 0.000161 Hspa5 heat shock protein 5 (Hspa5), transcript NM_022310 variant 2, mRNA. 6940658 -1.10763 0.000148 Abcg3 ATP-binding cassette, sub-family G NM_030239 (WHITE), member 3 (Abcg3), mRNA. 7019532 -1.10982 0.000637 Armcx6 armadillo repeat containing, X-linked 6 NM_001007578 (Armcx6), mRNA. 6766863 -1.11077 0.000103 Echdc1 enoyl Coenzyme A hydratase domain NM_025855 containing 1 (Echdc1), transcript variant 1, mRNA. 6919296 -1.11348 0.00097 Rps20 ribosomal protein S20 (Rps20), mRNA. NM_026147 6950985 -1.11377 0.000394 Lrmp lymphoid-restricted membrane protein NM_008511 (Lrmp), mRNA. 6882232 -1.11431 0.003935 Fkbp1a FK506 binding protein 1a (Fkbp1a), NM_008019 mRNA. 6847928 -1.11442 0.000152 Atp5o ATP synthase, H+ transporting, NM_138597 mitochondrial F1 complex, O subunit (Atp5o), nuclear gene encoding mitochondrial protein, mRNA. 6882666 -1.11572 0.000736 Rpn2 ribophorin II (Rpn2), mRNA. NM_019642 6832332 -1.11677 7.5E-05 Nup50 nucleoporin 50 (Nup50), mRNA. NM_016714 6849456 -1.11772 0.000136 Ergic1 endoplasmic reticulum-golgi intermediate NM_026170 compartment (ERGIC) 1 (Ergic1), mRNA.

6955770 -1.11864 0.002059 Uba3 ubiquitin-like modifier activating enzyme 3 NM_011666 (Uba3), transcript variant 1, mRNA. 6817930 -1.11936 7.63E-05 Tkt transketolase (Tkt), mRNA. NM_009388 6804525 -1.1197 0.000899 Akr1c13 aldo-keto reductase family 1, member C13 NM_013778 (Akr1c13), mRNA. 6788274 -1.12078 0.003292 Uqcrq ubiquinol-cytochrome c reductase, NM_025352 complex III subunit VII (Uqcrq), nuclear gene encoding mitochondrial protein, mRNA. 6971987 -1.12084 8.38E-07 Bnip3 BCL2/adenovirus E1B interacting protein 3 NM_009760 (Bnip3), nuclear gene encoding mitochondrial protein, mRNA. 6892344 -1.12097 0.002845 Ahcy S-adenosylhomocysteine hydrolase (Ahcy), NM_016661 mRNA. 6888309 -1.12134 0.000295 2700094K13Ri RIKEN cDNA 2700094K13 gene NM_001033166 k (2700094K13Rik), transcript variant 1, mRNA. 6854401 -1.12422 4.31E-05 Hn1l hematological and neurological expressed NM_198937 1-like (Hn1l), mRNA. 6828374 -1.1247 0.001681 Oxct1 3-oxoacid CoA transferase 1 (Oxct1), NM_024188 nuclear gene encoding mitochondrial protein, mRNA. 6818722 -1.12764 0.001013 Ktn1 kinectin 1 (Ktn1), mRNA. NM_008477 6855672 -1.12782 4.43E-05 Polh polymerase (DNA directed), eta (RAD 30 NM_030715 related) (Polh), mRNA. 6975235 -1.12999 6.68E-05 Gsr glutathione reductase (Gsr), mRNA. NM_010344 6837301 -1.1301 7.39E-05 Rangap1 RAN GTPase activating protein 1 NM_011241 (Rangap1), transcript variant 1, mRNA. 6795881 -1.13059 0.00024 Frmd6 FERM domain containing 6 (Frmd6), NM_028127 mRNA. 6893636 -1.13084 0.000426 Slmo2 slowmo homolog 2 (Drosophila) (Slmo2), NM_025531 mRNA. 6768232 -1.13089 0.005624 Ppa1 pyrophosphatase (inorganic) 1 (Ppa1), NM_026438 mRNA. 6971277 -1.13133 0.000311 Nupr1 nuclear protein 1 (Nupr1), mRNA. NM_019738 6802031 -1.13267 9.11E-06 Tmem229b transmembrane protein 229B NM_178745 (Tmem229b), transcript variant 1, mRNA.

6790902 -1.13285 0.001341 Nme1 non-metastatic cells 1, protein (NM23A) NM_008704 expressed in (Nme1), mRNA. 6934130 -1.13419 0.001437 Arpc3 actin related protein 2/3 complex, subunit 3 NM_019824 (Arpc3), mRNA. 6783909 -1.1356 0.000528 Mrpl45 mitochondrial ribosomal protein L45 NM_025927 (Mrpl45), nuclear gene encoding mitochondrial protein, mRNA. 6989406 -1.13585 0.000164 Cox5a cytochrome c oxidase, subunit Va (Cox5a), NM_007747 nuclear gene encoding mitochondrial protein, mRNA. 6850097 -1.1361 0.003289 Clic1 chloride intracellular channel 1 (Clic1), NM_033444 mRNA. 6748893 -1.13639 0.00077 Il18rap interleukin 18 receptor accessory protein NM_010553 (Il18rap), mRNA. 6912491 -1.13729 0.000932 Casp8ap2 caspase 8 associated protein 2 NM_011997 (Casp8ap2), transcript variant 1, mRNA. 6952936 -1.13898 0.000299 Slc37a3 solute carrier family 37 (glycerol-3- NM_028123 phosphate transporter), member 3 (Slc37a3), mRNA. 6860436 -1.13924 7.19E-05 Tcerg1 transcription elongation regulator 1 NM_001039474 (CA150) (Tcerg1), mRNA. 6790015 -1.13967 7.21E-07 Ksr1 kinase suppressor of ras 1 (Ksr1), mRNA. NM_013571

6861707 -1.14032 0.000126 Tubb6 tubulin, beta 6 (Tubb6), mRNA. NM_026473 6807251 -1.14136 0.000664 Tmed9 transmembrane emp24 protein transport NM_026211 domain containing 9 (Tmed9), mRNA. 6830927 -1.14159 0.000112 Myc myelocytomatosis oncogene (Myc), NM_010849 transcript variant 1, mRNA. 6980993 -1.14273 7.09E-06 Golga7 golgi autoantigen, golgin subfamily a, 7 NM_020585 (Golga7), transcript variant 1, mRNA. 6955778 -1.14334 3.03E-09 Frmd4b FERM domain containing 4B (Frmd4b), NM_145148 mRNA. 6925579 -1.14421 0.000203 Eif3i eukaryotic translation initiation factor 3, NM_018799 subunit I (Eif3i), mRNA. 6994579 -1.14484 0.003797 St3gal4 ST3 beta-galactoside alpha-2,3- NM_009178 sialyltransferase 4 (St3gal4), mRNA. 6998085 -1.14511 4.24E-09 Zbtb38 zinc finger and BTB domain containing 38 NM_175537 (Zbtb38), mRNA. 6792441 -1.14554 0.000711 Nt5c 5',3'-nucleotidase, cytosolic (Nt5c), mRNA. NM_015807

6790655 -1.14696 0.003134 Scpep1 serine carboxypeptidase 1 (Scpep1), NM_029023 mRNA. 6756345 -1.14708 4.37E-06 Nsl1 NSL1, MIND kinetochore complex NM_198654 component, homolog (S. cerevisiae) (Nsl1), mRNA. 6790478 -1.14716 6.43E-05 Ints2 integrator complex subunit 2 (Ints2), NM_027421 mRNA. 6998088 -1.14736 8.9E-07 Zbtb38 zinc finger and BTB domain containing 38 ENSMUST00000152594 gene:ENSMUSG00000040433 6778410 -1.14806 0.000147 Ascc2 activating signal cointegrator 1 complex NM_029291 subunit 2 (Ascc2), mRNA. 6901334 -1.14898 2.67E-05 Pla2g12a phospholipase A2, group XIIA (Pla2g12a), NM_023196 transcript variant 1, mRNA. 6791171 -1.14899 3.35E-05 Tbx21 T-box 21 (Tbx21), mRNA. NM_019507 6884441 -1.1505 5.43E-07 Mcm10 minichromosome maintenance deficient 10 NM_027290 (S. cerevisiae) (Mcm10), mRNA. 6981497 -1.15127 0.000421 Mak16 MAK16 homolog (S. cerevisiae) (Mak16), NM_026453 mRNA. 6866307 -1.15142 0.000411 Ptpn2 protein tyrosine phosphatase, non-receptor NM_001127177 type 2 (Ptpn2), transcript variant 2, mRNA.

6998076 -1.1519 0.00023 Rasa2 RAS p21 protein activator 2 (Rasa2), NM_053268 mRNA. 6793672 -1.15208 0.000605 Pdia6 protein disulfide isomerase associated 6 NM_027959 (Pdia6), mRNA. 6821298 -1.15329 2.2E-06 6720463M24Ri RIKEN cDNA 6720463M24 gene NM_175265 k (6720463M24Rik), mRNA. 6931182 -1.15442 0.00019 Tbc1d1 TBC1 domain family, member 1 (Tbc1d1), NM_019636 mRNA. 6872528 -1.15481 0.000401 Insl6 insulin-like 6 (Insl6), mRNA. NM_013754 6977804 -1.15514 0.000754 Orc6 origin recognition complex, subunit 6 NM_019716 (Orc6), transcript variant 1, mRNA. 6940646 -1.15625 0.000117 Gbp8 guanylate-binding protein 8 (Gbp8), mRNA. NM_029509

6927075 -1.15852 0.000605 Park7 Parkinson disease (autosomal recessive, NM_020569 early onset) 7 (Park7), mRNA. 6999070 -1.15853 6.57E-05 Pdcd6ip programmed cell death 6 interacting NM_001164677 protein (Pdcd6ip), transcript variant 1, mRNA. 6802349 -1.15873 0.00027 Npc2 Niemann Pick type C2 (Npc2), mRNA. NM_023409 7018993 -1.1601 0.000406 Chm choroidermia (Chm), mRNA. NM_018818 6990042 -1.16079 2.58E-05 Car12 carbonic anyhydrase 12 (Car12), mRNA. NM_178396 6924466 -1.16399 0.002769 Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, NM_007671 inhibits CDK4) (Cdkn2c), mRNA. 6982181 -1.16482 0.00015 Ccdc111 coiled-coil domain containing 111 NM_001001184 (Ccdc111), mRNA. 6962751 -1.16534 1.47E-05 Alg8 asparagine-linked glycosylation 8 homolog NM_199035 (yeast, alpha-1,3-glucosyltransferase) (Alg8), mRNA. 6767636 -1.16578 0.002283 Gpx4 glutathione peroxidase 4 (Gpx4), transcript NM_008162 variant 2, mRNA. 6884305 -1.16587 0.000472 Polr3k polymerase (RNA) III (DNA directed) NM_025901 polypeptide K (Polr3k), mRNA. 6766772 -1.16686 0.00017 Arhgap18 Rho GTPase activating protein 18 NM_176837 (Arhgap18), mRNA. 6924801 -1.1672 0.000837 Nasp nuclear autoantigenic sperm protein NM_016777 (histone-binding) (Nasp), transcript variant 2, mRNA. 6970568 -1.1691 0.000171 Btbd10 BTB (POZ) domain containing 10 (Btbd10), NM_133700 mRNA. 6970635 -1.17029 0.000105 Rras2 related RAS viral (r-ras) oncogene NM_025846 homolog 2 (Rras2), mRNA. 6959459 -1.1703 0.000148 Ech1 enoyl coenzyme A hydratase 1, NM_016772 peroxisomal (Ech1), mRNA. 4926106 -1.17039 0.00205 --- AFFX-r2-Bs-dap-M_st, polya_spike --- 6925236 -1.17061 0.00019 Utp11l UTP11-like, U3 small nucleolar NM_026031 ribonucleoprotein, (yeast) (Utp11l), mRNA.

6996356 -1.17262 0.000426 Plekho2 pleckstrin homology domain containing, NM_153119 family O member 2 (Plekho2), mRNA. 6901335 -1.17288 5.89E-05 Casp6 caspase 6 (Casp6), mRNA. NM_009811 6916663 -1.17633 3.3E-05 Slc6a9 solute carrier family 6 (neurotransmitter NM_008135 transporter, glycine), member 9 (Slc6a9), mRNA. 6855088 -1.17712 4.89E-05 Lta lymphotoxin A (Lta), mRNA. NM_010735 6975613 -1.17744 0.002386 Zdhhc2 zinc finger, DHHC domain containing 2 NM_178395 (Zdhhc2), mRNA. 6897009 -1.17844 0.004477 Larp1b La ribonucleoprotein domain family, NM_001040399 member 1B (Larp1b), mRNA. 6871277 -1.17855 0.000185 Stip1 stress-induced phosphoprotein 1 (Stip1), NM_016737 mRNA. 6817367 -1.17905 0.000352 Chchd1 coiled-coil-helix-coiled-coil-helix domain NM_025366 containing 1 (Chchd1), mRNA. 6951281 -1.17926 0.00081 Samd9l sterile alpha motif domain containing 9-like NM_010156 (Samd9l), mRNA. 6948008 -1.17929 0.005645 Lsm3 LSM3 homolog, U6 small nuclear RNA NM_026309 associated (S. cerevisiae) (Lsm3), mRNA.

6833404 -1.17934 1.23E-05 Espl1 extra spindle poles-like 1 (S. cerevisiae) NM_001014976 (Espl1), mRNA. 6799205 -1.18073 0.000132 Lpin1 lipin 1 (Lpin1), transcript variant 2, mRNA. NM_015763

6777902 -1.18143 3.66E-05 Tspan31 tetraspanin 31 (Tspan31), mRNA. NM_025982 6869436 -1.18191 0.000117 Hectd2 HECT domain containing 2 (Hectd2), NM_001163471 transcript variant 1, mRNA. 6806036 -1.18312 0.00223 Serpinb9 serine (or cysteine) peptidase inhibitor, NM_009256 clade B, member 9 (Serpinb9), mRNA. 6844253 -1.18454 8.64E-06 Sdf2l1 stromal cell-derived factor 2-like 1 (Sdf2l1), NM_022324 mRNA. 6994586 -1.18463 7.15E-07 Tirap toll-interleukin 1 receptor (TIR) domain- NM_001177845 containing adaptor protein (Tirap), transcript variant 1, mRNA. 6762796 -1.18503 0.002308 Rgs1 regulator of G-protein signaling 1 (Rgs1), NM_015811 mRNA. 6788020 -1.18503 1.98E-05 Canx calnexin (Canx), transcript variant 1, NM_007597 mRNA. 6791921 -1.18581 7.45E-05 Ern1 endoplasmic reticulum (ER) to nucleus NM_023913 signalling 1 (Ern1), mRNA. 6810066 -1.1876 0.000618 Depdc1b DEP domain containing 1B (Depdc1b), NM_178683 mRNA. 6808308 -1.18774 0.00074 Ell2 elongation factor RNA polymerase II 2 NM_138953 (Ell2), mRNA. 7011124 -1.18793 0.000278 2610018G03Ri RIKEN cDNA 2610018G03 gene NM_133729 k (2610018G03Rik), mRNA. 6788661 -1.1881 0.002942 Arf1 ADP-ribosylation factor 1 (Arf1), transcript NM_001130408 variant 1, mRNA. 6971678 -1.18914 1.88E-05 Oat ornithine aminotransferase (Oat), nuclear NM_016978 gene encoding mitochondrial protein, mRNA. 6984999 -1.19044 3.91E-07 Cenpt centromere protein T (Cenpt), mRNA. NM_177150 6882189 -1.19104 1.59E-06 Gins1 GINS complex subunit 1 (Psf1 homolog) NM_027014 (Gins1), transcript variant 1, mRNA. 6935756 -1.19172 6.14E-06 Brca2 breast cancer 2 (Brca2), transcript variant NM_001081001 1, mRNA. 6836959 -1.19194 4.24E-05 Apol7c apolipoprotein L 7c (Apol7c), mRNA. NM_175391 6803871 -1.19383 0.004831 2010107E04Ri RIKEN cDNA 2010107E04 gene NM_027360 k (2010107E04Rik), mRNA. 6945775 -1.19721 5.08E-06 Gstk1 glutathione S-transferase kappa 1 (Gstk1), NM_029555 nuclear gene encoding mitochondrial protein, mRNA. 6808948 -1.19782 9.34E-05 Dhfr dihydrofolate reductase (Dhfr), mRNA. NM_010049 6796048 -1.19929 5.31E-05 Hif1a hypoxia inducible factor 1, alpha subunit NM_010431 (Hif1a), mRNA. 6892496 -1.19951 1.27E-05 Dsn1 DSN1, MIND kinetochore complex NM_025853 component, homolog (S. cerevisiae) (Dsn1), mRNA. 6883000 -1.1996 8.97E-06 Mybl2 myeloblastosis oncogene-like 2 (Mybl2), NM_008652 mRNA. 6963907 -1.19981 5.55E-08 Tmem159 transmembrane protein 159 (Tmem159), NM_145586 mRNA. 6806435 -1.20026 2.65E-08 Gcnt2 glucosaminyl (N-acetyl) transferase 2, I- NM_023887 branching enzyme (Gcnt2), transcript variant 2, mRNA. 6871377 -1.20081 0.000209 Polr2g polymerase (RNA) II (DNA directed) NM_026329 polypeptide G (Polr2g), mRNA. 6760777 -1.20139 4.46E-05 Hdlbp high density lipoprotein (HDL) binding NM_133808 protein (Hdlbp), mRNA. 6792097 -1.20202 0.000576 Slc16a6 solute carrier family 16 (monocarboxylic NM_001029842 acid transporters), member 6 (Slc16a6), transcript variant 1, mRNA. 6819143 -1.20297 0.000395 Abhd4 abhydrolase domain containing 4 (Abhd4), NM_134076 mRNA. 6925149 -1.20384 4.27E-06 Mfsd2a major facilitator superfamily domain NM_029662 containing 2A (Mfsd2a), mRNA. 6936693 -1.20433 0.002426 Tomm7 translocase of outer mitochondrial NM_025394 membrane 7 homolog (yeast) (Tomm7), nuclear gene encoding mitochondrial protein, mRNA. 6866660 -1.2064 0.000478 Ska1 spindle and kinetochore associated NM_025581 complex subunit 1 (Ska1), transcript variant 1, mRNA. 6867197 -1.20675 0.001599 Cndp2 CNDP dipeptidase 2 (metallopeptidase NM_023149 M20 family) (Cndp2), mRNA. 6866116 -1.20729 0.000135 Nars asparaginyl-tRNA synthetase (Nars), NM_001142950 transcript variant 1, mRNA. 6873133 -1.21 0.00053 Pik3ap1 phosphoinositide-3-kinase adaptor protein NM_031376 1 (Pik3ap1), mRNA. 6804898 -1.2106 0.001232 Lyst lysosomal trafficking regulator (Lyst), NM_010748 mRNA. 6817611 -1.21085 9.46E-06 Zmiz1 zinc finger, MIZ-type containing 1 (Zmiz1), NM_183208 mRNA. 6775238 -1.21249 1.19E-05 Pfkl phosphofructokinase, liver, B-type (Pfkl), NM_008826 mRNA. 6769138 -1.21271 8.38E-05 Bsg basigin (Bsg), transcript variant 1, mRNA. NM_009768

6932598 -1.21277 0.000261 Mrpl1 mitochondrial ribosomal protein L1 (Mrpl1), NM_053158 nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.

6753700 -1.21391 5.21E-05 B3galt2 UDP-Gal:betaGlcNAc beta 1,3- NM_020025 galactosyltransferase, polypeptide 2 (B3galt2), mRNA. 6867973 -1.21415 0.002885 1810009A15Ri RIKEN cDNA 1810009A15 gene, mRNA BC047099 k (cDNA clone MGC:30989 IMAGE:5253822), complete cds. 6871476 -1.2148 0.00664 Fen1 flap structure specific endonuclease 1 NM_007999 (Fen1), mRNA. 6850681 -1.21548 0.000307 Gtpbp2 GTP binding protein 2 (Gtpbp2), transcript NM_019581 variant 1, mRNA. 6833100 -1.21724 2.1E-05 Cacnb3 calcium channel, voltage-dependent, beta NM_007581 3 subunit (Cacnb3), transcript variant 1, mRNA. 6907972 -1.2187 0.002544 Olfr266 olfactory receptor 266 (Olfr266), mRNA. NM_146489 4401640 -1.2209 9.99E-05 --- AFFX-r2-Bs-phe-3_st, polya_spike --- 6755387 -1.22181 1.31E-06 Exo1 exonuclease 1 (Exo1), mRNA. NM_012012 6805359 -1.22228 0.004541 Hist1h1d histone cluster 1, H1d (Hist1h1d), mRNA. NM_145713

6993833 -1.22232 0.000133 Spc24 SPC24, NDC80 kinetochore complex NM_026282 component, homolog (S. cerevisiae) (Spc24), mRNA. 6959474 -1.22352 7.06E-06 Rasgrp4 RAS guanyl releasing protein 4 (Rasgrp4), NM_001174155 transcript variant 1, mRNA. 6777929 -1.22445 8.9E-05 Mars methionine-tRNA synthetase (Mars), NM_001171582 transcript variant 1, mRNA. 6796696 -1.2256 2.22E-08 Jdp2 Jun dimerization protein 2 (Jdp2), mRNA. NM_030887

6780961 -1.22758 0.000158 Zcchc10 zinc finger, CCHC domain containing 10 NM_026479 (Zcchc10), mRNA. 6815558 -1.2286 0.000845 Ccnb1 cyclin B1 (Ccnb1), mRNA. NM_172301 6933226 -1.23047 2.07E-06 Cdc7 cell division cycle 7 (S. cerevisiae) (Cdc7), NM_009863 mRNA. 6835776 -1.23363 3.46E-06 Dscc1 defective in sister chromatid cohesion 1 NM_183089 homolog (S. cerevisiae) (Dscc1), mRNA. 6775472 -1.2342 0.000394 Gna15 guanine nucleotide binding protein, alpha NM_010304 15 (Gna15), mRNA. 6922324 -1.23481 0.000321 Tnfsf8 tumor necrosis factor (ligand) superfamily, NM_009403 member 8 (Tnfsf8), mRNA. 6971272 -1.23572 0.000225 Eif3c eukaryotic translation initiation factor 3, NM_146200 subunit C (Eif3c), mRNA. 6824850 -1.23667 0.000102 Sdr39u1 short chain dehydrogenase/reductase NM_001082975 family 39U, member 1 (Sdr39u1), mRNA.

6834013 -1.23702 0.000744 Tars threonyl-tRNA synthetase (Tars), mRNA. NM_033074

6838797 -1.24096 0.000546 Cbx5 chromobox homolog 5 (Drosophila HP1a) NM_001110216 (Cbx5), transcript variant 3, mRNA.

6871515 -1.24275 0.000548 Tmem109 transmembrane protein 109 (Tmem109), NM_134142 mRNA. 6899722 -1.24291 0.000983 Anp32e acidic (leucine-rich) nuclear NM_023210 phosphoprotein 32 family, member E (Anp32e), mRNA. 6935490 -1.24306 0.000345 Arpc1b actin related protein 2/3 complex, subunit NM_023142 1B (Arpc1b), mRNA. 6771533 -1.24693 0.001093 Mettl1 methyltransferase like 1 (Mettl1), mRNA. NM_010792

6964232 -1.24793 7.14E-05 Ccdc101 coiled-coil domain containing 101 NM_029339 (Ccdc101), mRNA. 6959460 -1.24875 0.004496 Lgals4 lectin, galactose binding, soluble 4 NM_010706 (Lgals4), mRNA. 6782465 -1.24927 5.42E-05 Ywhae tyrosine 3-monooxygenase/tryptophan 5- NM_009536 monooxygenase activation protein, epsilon polypeptide (Ywhae), mRNA. 6953339 -1.25014 0.001606 Pdia4 protein disulfide isomerase associated 4 NM_009787 (Pdia4), mRNA. 6917495 -1.25168 3.18E-06 Atpif1 ATPase inhibitory factor 1 (Atpif1), nuclear NM_007512 gene encoding mitochondrial protein, mRNA. 6792534 -1.25185 6.6E-07 Rhbdf2 rhomboid 5 homolog 2 (Drosophila) NM_172572 (Rhbdf2), transcript variant 1, mRNA. 6879915 -1.25486 3.2E-05 Kif18a kinesin family member 18A (Kif18a), NM_139303 mRNA. 6942604 -1.25576 0.001018 Mcm7 minichromosome maintenance deficient 7 NM_008568 (S. cerevisiae) (Mcm7), mRNA. 6951453 -1.25663 0.004079 Shfm1 split hand/foot malformation (ectrodactyly) NM_009169 type 1 (Shfm1), mRNA. 6892307 -1.25717 8.21E-07 E2f1 E2F transcription factor 1 (E2f1), mRNA. NM_007891 6957465 -1.25882 3.02E-05 Csda cold shock domain protein A (Csda), NM_139117 transcript variant 1, mRNA. 6771527 -1.26149 0.000968 Avil advillin (Avil), mRNA. NM_009635 6941934 -1.26198 4.79E-08 Scarb1 scavenger receptor class B, member 1 NM_016741 (Scarb1), mRNA. 6994589 -1.26326 0.001303 Fam118b family with sequence similarity 118, BC051180 member B, mRNA (cDNA clone MGC:56940 IMAGE:6315210), complete cds. 6980959 -1.26355 9.95E-05 Vdac3 voltage-dependent anion channel 3 NM_011696 (Vdac3), mRNA. 6960298 -1.26384 6.17E-06 Nup62 nucleoporin 62 (Nup62), mRNA. NM_053074 6913080 -1.26509 6.34E-05 Melk maternal embryonic leucine zipper kinase NM_010790 (Melk), mRNA. 6926072 -1.26715 2E-06 Clic4 chloride intracellular channel 4 NM_013885 (mitochondrial) (Clic4), nuclear gene encoding mitochondrial protein, mRNA. 6798429 -1.27043 1.2E-05 Cdca7l cell division cycle associated 7 like NM_146040 (Cdca7l), mRNA. 6824893 -1.27238 0.000202 Cenpj centromere protein J (Cenpj), mRNA. NM_001014996 6890448 -1.27242 4.9E-07 Gatm glycine amidinotransferase (L- NM_025961 arginine:glycine amidinotransferase) (Gatm), nuclear gene encoding mitochondrial protein, mRNA. 6905192 -1.2759 0.001736 Exosc8 exosome component 8 (Exosc8), transcript NM_001163570 variant 1, mRNA. 6867849 -1.27641 2.42E-05 Ehd1 EH-domain containing 1 (Ehd1), mRNA. NM_010119 6916127 -1.27665 9.8E-05 Tmem48 transmembrane protein 48 (Tmem48), NM_028355 mRNA. 6971996 -1.27689 1.04E-07 Stk32c serine/threonine kinase 32C (Stk32c), NM_021302 transcript variant 1, mRNA. 6801454 -1.27928 2.66E-06 Pole2 polymerase (DNA directed), epsilon 2 (p59 NM_011133 subunit) (Pole2), mRNA. 6870566 -1.28009 0.00056 Acsl5 acyl-CoA synthetase long-chain family NM_027976 member 5 (Acsl5), mRNA. 6840637 -1.28107 4.65E-06 Itgb5 integrin beta 5 (Itgb5), transcript variant 1, NM_001145884 mRNA. 7011953 -1.28209 0.001988 Ssr4 signal sequence receptor, delta (Ssr4), NM_001166480 transcript variant 1, mRNA. 6885195 -1.28212 3.76E-06 Arhgap21 Rho GTPase activating protein 21 NM_001128084 (Arhgap21), transcript variant 1, mRNA. 6840782 -1.28381 1.33E-05 Polq polymerase (DNA directed), theta (Polq), NM_029977 transcript variant 1, mRNA. 6963901 -1.28596 1.19E-06 Lyrm1 LYR motif containing 1 (Lyrm1), mRNA. NM_029610 6798272 -1.2865 3.36E-05 Siva1 SIVA1, apoptosis-inducing factor (Siva1), NM_013929 transcript variant 1, mRNA. 6789977 -1.28677 2.74E-05 Tmem97 transmembrane protein 97 (Tmem97), NM_133706 mRNA. 6777346 -1.28712 0.000163 Mdm2 transformed mouse 3T3 cell double minute NM_010786 2 (Mdm2), mRNA. 6919212 -1.28796 0.004994 Tnfrsf18 tumor necrosis factor receptor superfamily, NM_009400 member 18 (Tnfrsf18), transcript variant 1, mRNA. 6903549 -1.28957 5E-05 Gyg glycogenin (Gyg), mRNA. NM_013755 6976002 -1.29032 0.000242 Dctd dCMP deaminase (Dctd), transcript variant NR_027759 4, non-coding RNA. 6970749 -1.29074 3.2E-05 Rps13 ribosomal protein S13 (Rps13), mRNA. NM_026533 6877297 -1.29574 4.46E-05 Gpd2 glycerol phosphate dehydrogenase 2, NM_001145820 mitochondrial (Gpd2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6855116 -1.29611 1.49E-05 Tcf19 transcription factor 19 (Tcf19), transcript NM_001163763 variant 1, mRNA. 6770646 -1.29677 1.5E-05 E2f7 E2F transcription factor 7 (E2f7), mRNA. NM_178609 6762017 -1.29679 0.00016 Mcm6 minichromosome maintenance deficient 6 NM_008567 (MIS5 homolog, S. pombe) (S. cerevisiae) (Mcm6), mRNA. 6989483 -1.2972 7.33E-05 Nptn neuroplastin (Nptn), mRNA. NM_009145 6997634 -1.29783 0.003818 2810026P18Ri RIKEN cDNA 2810026P18 gene, mRNA BC032970 k (cDNA clone IMAGE:1224948), complete cds. 6917129 -1.29918 1.8E-05 Stk40 serine/threonine kinase 40 (Stk40), NM_001145827 transcript variant 1, mRNA. 6807156 -1.29967 0.000483 Hrh2 histamine receptor H2 (Hrh2), transcript NM_001010973 variant 1, mRNA. 6820109 -1.30027 0.000189 Dok2 docking protein 2 (Dok2), mRNA. NM_010071 6899146 -1.30056 0.002828 Ssr2 signal sequence receptor, beta (Ssr2), NM_025448 mRNA. 6807609 -1.30473 0.000481 2010111I01Rik RIKEN cDNA 2010111I01 gene NM_028079 (2010111I01Rik), mRNA. 6876380 -1.30583 1.57E-09 Gsn gelsolin (Gsn), mRNA. NM_146120 6939077 -1.30676 0.000435 Tec tec protein tyrosine kinase (Tec), transcript NM_001113460 variant 1, mRNA. 6908137 -1.31774 7.46E-05 Gpsm2 G-protein signalling modulator 2 (AGS3- NM_029522 like, C. elegans) (Gpsm2), mRNA. 7005797 -1.3182 0.000244 Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A NM_145942 synthase 1 (Hmgcs1), mRNA. 6781969 -1.31822 3.48E-06 1500010J02Ri RIKEN cDNA 1500010J02 gene NR_026565 k (1500010J02Rik), transcript variant 2, non- coding RNA. 6847190 -1.31884 0.001212 Samsn1 SAM domain, SH3 domain and nuclear NM_023380 localization signals, 1 (Samsn1), mRNA.

6958193 -1.31913 3.69E-05 Bcat1 branched chain aminotransferase 1, NM_007532 cytosolic (Bcat1), transcript variant 2, mRNA. 6767537 -1.31951 0.00853 Cd24a CD24a antigen (Cd24a), mRNA. NM_009846 6975913 -1.32225 0.00024 Casp3 caspase 3 (Casp3), mRNA. NM_009810 6909310 -1.32238 0.000148 Ccdc109b coiled-coil domain containing 109B NM_025779 (Ccdc109b), mRNA. 6900450 -1.32379 2.28E-05 Slc25a24 solute carrier family 25 (mitochondrial NM_172685 carrier, phosphate carrier), member 24 (Slc25a24), nuclear gene encoding mitochondrial protein, mRNA. 6875132 -1.32656 0.00103 Vim vimentin (Vim), mRNA. NM_011701 6907864 -1.32738 2.55E-06 Fam19a3 family with sequence similarity 19, member NM_183224 A3 (Fam19a3), mRNA. 6806073 -1.3286 0.00015 Nqo2 NAD(P)H dehydrogenase, quinone 2 NM_020282 (Nqo2), transcript variant 1, mRNA. 6824325 -1.32904 2.49E-05 Wdhd1 WD repeat and HMG-box DNA binding NM_172598 protein 1 (Wdhd1), mRNA. 6854514 -1.33131 0.000211 Bak1 BCL2-antagonist/killer 1 (Bak1), mRNA. NM_007523 6878053 -1.33261 4.87E-06 Cdca7 cell division cycle associated 7 (Cdca7), NM_025866 mRNA. 6849287 -1.33413 0.004771 Rnps1 ribonucleic acid binding protein S1 NM_009070 (Rnps1), transcript variant 1, mRNA. 6750868 -1.33651 3.51E-05 Acsl3 acyl-CoA synthetase long-chain family NM_028817 member 3 (Acsl3), transcript variant 1, mRNA. 6963422 -1.33754 8.02E-08 Swap70 SWA-70 protein (Swap70), mRNA. NM_009302 6866299 -1.33889 4.94E-05 Afg3l2 AFG3(ATPase family gene 3)-like 2 (yeast) NM_027130 (Afg3l2), mRNA. 6987638 -1.33902 4.7E-06 Vps26b vacuolar protein sorting 26 homolog B NM_178027 (yeast) (Vps26b), mRNA. 6906840 -1.33917 5.03E-06 Cks1b CDC28 protein kinase 1b (Cks1b), mRNA. NM_016904

6991991 -1.3397 2.76E-08 Ryk receptor-like tyrosine kinase (Ryk), NM_013649 transcript variant 1, mRNA. 6832142 -1.34066 0.001807 Aco2 aconitase 2, mitochondrial (Aco2), nuclear NM_080633 gene encoding mitochondrial protein, mRNA. 6764721 -1.3413 0.000582 Capn2 calpain 2 (Capn2), mRNA. NM_009794 6855526 -1.3419 0.000553 Enpp4 ectonucleotide NM_199016 pyrophosphatase/phosphodiesterase 4 (Enpp4), mRNA. 6928741 -1.34219 0.000212 Abcb1b ATP-binding cassette, sub-family B NM_011075 (MDR/TAP), member 1B (Abcb1b), mRNA.

6963413 -1.34394 0.000421 Ipo7 importin 7 (Ipo7), mRNA. NM_181517 6748886 -1.34599 1.17E-06 Il1rl2 interleukin 1 receptor-like 2 (Il1rl2), mRNA. NM_133193

6791139 -1.34704 0.000169 Nfe2l1 nuclear factor, erythroid derived 2,-like 1 NM_008686 (Nfe2l1), transcript variant 1, mRNA. 6915734 -1.34859 0.003952 Usp1 ubiquitin specific peptidase 1 (Usp1), NM_146144 mRNA. 6934162 -1.34893 7.41E-05 P2rx7 purinergic receptor P2X, ligand-gated ion NM_011027 channel, 7 (P2rx7), transcript variant 1, mRNA. 6982690 -1.3493 6.81E-05 Sap30 sin3 associated polypeptide (Sap30), NM_021788 mRNA. 6996646 -1.34947 0.001896 Ccnb2 cyclin B2 (Ccnb2), mRNA. NM_007630 6977768 -1.35181 1.19E-06 Syce2 synaptonemal complex central element NM_001168246 protein 2 (Syce2), transcript variant 1, mRNA. 6857544 -1.35297 1.2E-05 Sos1 son of sevenless homolog 1 (Drosophila) NM_009231 (Sos1), mRNA. 6757732 -1.35678 0.000135 Prim2 DNA primase, p58 subunit (Prim2), mRNA. NM_008922

6869766 -1.35686 2.06E-07 Ubtd1 ubiquitin domain containing 1 (Ubtd1), NM_145500 mRNA. 6968790 -1.35696 1.54E-05 Blm Bloom syndrome, RecQ helicase-like NM_007550 (Blm), transcript variant 1, mRNA. 6759782 -1.35704 1.44E-05 Tuba4a tubulin, alpha 4A (Tuba4a), mRNA. NM_009447 6923058 -1.35737 0.000486 Haus6 HAUS augmin-like complex, subunit 6 NM_173400 (Haus6), mRNA. 6948913 -1.35897 0.000117 Bhlhe40 basic helix-loop-helix family, member e40 NM_011498 (Bhlhe40), mRNA. 6904972 -1.35925 2.1E-05 4930583H14Ri RIKEN cDNA 4930583H14 gene NR_028121 k (4930583H14Rik), transcript variant 2, non- coding RNA. 6998596 -1.35981 1.43E-06 Manf mesencephalic astrocyte-derived NM_029103 neurotrophic factor (Manf), mRNA. 6810717 -1.36022 3.72E-06 Akr1e1 aldo-keto reductase family 1, member E1 NM_018859 (Akr1e1), mRNA. 6979421 -1.36544 5.52E-05 Cenpn centromere protein N (Cenpn), mRNA. NM_028131 6905405 -1.36573 0.000182 Gpr171 G protein-coupled receptor 171 (Gpr171), NM_173398 mRNA. 6942669 -1.36583 7.22E-07 Adap1 ArfGAP with dual PH domains 1 (Adap1), NM_172723 mRNA. 6966465 -1.36612 0.000106 Cebpg CCAAT/enhancer binding protein (C/EBP), NM_009884 gamma (Cebpg), mRNA. 6936981 -1.36762 4.47E-06 Tyms thymidylate synthase (Tyms), transcript NM_021288 variant 1, mRNA. 6754696 -1.36845 0.000233 Slc19a2 solute carrier family 19 (thiamine NM_054087 transporter), member 2 (Slc19a2), mRNA.

6955381 -1.36871 0.000273 Mcm2 minichromosome maintenance deficient 2 NM_008564 mitotin (S. cerevisiae) (Mcm2), mRNA. 6865022 -1.36988 0.000228 Lars leucyl-tRNA synthetase (Lars), mRNA. NM_134137 6915791 -1.37155 1.29E-05 Pgm2 phosphoglucomutase 2 (Pgm2), mRNA. NM_028132 6955431 -1.37189 3.1E-07 Plxna1 plexin A1 (Plxna1), mRNA. NM_008881 6850033 -1.37357 7.78E-05 H2-Ab1 histocompatibility 2, class II antigen A, beta NM_207105 1 (H2-Ab1), mRNA. 6780983 -1.37453 4.11E-07 8-Sep septin 8 (Sept8), mRNA. NM_033144 6880853 -1.37853 1.8E-06 Dut deoxyuridine triphosphatase (Dut), nuclear NM_023595 gene encoding mitochondrial protein, transcript variant 2, mRNA. 6929849 -1.37865 5.69E-06 Sh3bp2 SH3-domain binding protein 2 (Sh3bp2), NM_001145859 transcript variant 2, mRNA. 6947814 -1.38144 1.58E-06 Mgll monoglyceride lipase (Mgll), transcript NM_001166251 variant 1, mRNA. 6941294 -1.38354 0.000359 Cox6a1 cytochrome c oxidase, subunit VI a, NM_007748 polypeptide 1 (Cox6a1), nuclear gene encoding mitochondrial protein, mRNA. 6893486 -1.38379 6.81E-05 Aurka aurora kinase A (Aurka), mRNA. NM_011497 6917270 -1.38446 4.89E-05 Ak2 adenylate kinase 2 (Ak2), transcript variant NM_016895 2, mRNA. 6815555 -1.38539 3.89E-05 Cenph centromere protein H (Cenph), mRNA. NM_021886 6973937 -1.38608 8.77E-07 Tnfsf13b tumor necrosis factor (ligand) superfamily, NM_033622 member 13b (Tnfsf13b), mRNA.

6961932 -1.38736 4.12E-05 5730590G19Ri RIKEN cDNA 5730590G19 gene NM_029835 k (5730590G19Rik), mRNA. 7015375 -1.39057 8.06E-07 Clcn5 chloride channel 5 (Clcn5), mRNA. NM_016691 6825853 -1.39082 0.000442 Fndc3a fibronectin type III domain containing 3A NM_207636 (Fndc3a), mRNA. 6933677 -1.39183 0.000328 Rplp0 ribosomal protein, large, P0 (Rplp0), NM_007475 mRNA. 6878655 -1.39335 7.04E-05 Itgav integrin alpha V (Itgav), mRNA. NM_008402 6859953 -1.39431 0.000123 Kif20a kinesin family member 20A (Kif20a), NM_001166406 transcript variant 1, mRNA. 6912179 -1.39618 1.6E-05 F730047E07Ri RIKEN cDNA F730047E07 gene NM_199467 k (F730047E07Rik), mRNA. 6986090 -1.39687 5.03E-05 Egln1 EGL nine homolog 1 (C. elegans) (Egln1), NM_053207 mRNA. 6775758 -1.39785 1.61E-05 Hsp90b1 heat shock protein 90, beta (Grp94), NM_011631 member 1 (Hsp90b1), mRNA. 6783296 -1.39798 4.37E-07 Fam33a family with sequence similarity 33, member NM_025377 A (Fam33a), mRNA. 6971548 -1.39903 0.002792 Rfwd3 ring finger and WD repeat domain 3 NM_146218 (Rfwd3), mRNA. 6924763 -1.40035 2.51E-06 Rad54l RAD54 like (S. cerevisiae) (Rad54l), NM_009015 transcript variant 1, mRNA. 6889510 -1.40061 0.000249 2700007P21Ri RIKEN cDNA 2700007P21 gene NM_001025102 k (2700007P21Rik), transcript variant 1, mRNA. 6971320 -1.40254 5.43E-05 Kif22 kinesin family member 22 (Kif22), mRNA. NM_145588

6889357 -1.40447 0.001486 Prrg4 proline rich Gla (G-carboxyglutamic acid) 4 NM_178695 (transmembrane) (Prrg4), mRNA. 6892991 -1.40516 3.34E-05 Elmo2 engulfment and cell motility 2, ced-12 NM_207706 homolog (C. elegans) (Elmo2), transcript variant 2, mRNA. 6775977 -1.40645 3.35E-05 Apaf1 apoptotic peptidase activating factor 1 NM_001042558 (Apaf1), transcript variant 1, mRNA. 6866504 -1.40701 0.00036 4930503L19Ri RIKEN cDNA 4930503L19 gene, mRNA BC057927 k (cDNA clone MGC:67671 IMAGE:5290837), complete cds. 6815291 -1.40802 4.99E-05 Polk polymerase (DNA directed), kappa (Polk), NM_012048 mRNA. 6854690 -1.40813 8.65E-05 Ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 NM_026845 (Ppil1), mRNA. 6899028 -1.40849 0.000275 Hdgf hepatoma-derived growth factor (Hdgf), NM_008231 mRNA. 6915843 -1.41342 7.98E-05 Ak4 adenylate kinase 4 (Ak4), nuclear gene NM_001177602 encoding mitochondrial protein, transcript variant 1, mRNA. 6825686 -1.4167 2.92E-06 Ppp3cc protein phosphatase 3, catalytic subunit, NM_008915 gamma isoform (Ppp3cc), mRNA.

6983223 -1.41739 2.12E-05 Ifi30 interferon gamma inducible protein 30 NM_023065 (Ifi30), mRNA. 6798946 -1.41864 0.000171 Gen1 Gen homolog 1, endonuclease NM_177331 (Drosophila) (Gen1), mRNA. 6768324 -1.42345 1.6E-06 Dna2 DNA replication helicase 2 homolog (yeast) NM_177372 (Dna2), mRNA. 6917037 -1.43028 5.35E-05 Fhl3 four and a half LIM domains 3 (Fhl3), NM_010213 mRNA. 6971293 -1.43044 2.97E-07 Aldoa aldolase A, fructose-bisphosphate (Aldoa), NM_001177308 transcript variant 3, mRNA. 6874947 -1.43079 9.21E-05 Itih5 inter-alpha (globulin) inhibitor H5 (Itih5), NM_172471 mRNA. 6916089 -1.4344 6.29E-07 Dhcr24 24-dehydrocholesterol reductase (Dhcr24), NM_053272 mRNA. 6952900 -1.43752 3.13E-06 Hipk2 homeodomain interacting protein kinase 2 NM_010433 (Hipk2), transcript variant 2, mRNA. 6864444 -1.43831 2.55E-05 Stard4 StAR-related lipid transfer (START) NM_133774 domain containing 4 (Stard4), mRNA. 6886678 -1.443 1.21E-07 Rnd3 Rho family GTPase 3 (Rnd3), mRNA. NM_028810 6949680 -1.44437 0.003375 M6pr mannose-6-phosphate receptor, cation NM_010749 dependent (M6pr), mRNA. 6873246 -1.44475 1E-07 Erlin1 ER lipid raft associated 1 (Erlin1), NM_145502 transcript variant 1, mRNA. 6943195 -1.44531 9.66E-05 Slc7a1 solute carrier family 7 (cationic amino acid NM_007513 transporter, y+ system), member 1 (Slc7a1), mRNA. 6933459 -1.44536 4.08E-08 Chek2 CHK2 checkpoint homolog (S. pombe) NM_016681 (Chek2), mRNA. 6838469 -1.44553 0.000633 Racgap1 Rac GTPase-activating protein 1 NM_012025 (Racgap1), mRNA. 6887337 -1.44608 0.000574 Galnt3 UDP-N-acetyl-alpha-D- NM_015736 galactosamine:polypeptide N- acetylgalactosaminyltransferase 3 (Galnt3), mRNA. 6851204 -1.44631 3.72E-07 Chaf1a chromatin assembly factor 1, subunit A NM_013733 (p150) (Chaf1a), mRNA. 6819276 -1.44723 9.1E-06 Ltb4r1 leukotriene B4 receptor 1 (Ltb4r1), mRNA. NM_008519

6782694 -1.44806 7.55E-05 Aldoc aldolase C, fructose-bisphosphate (Aldoc), NM_009657 mRNA. 6916748 -1.44979 3.69E-05 Slc2a1 solute carrier family 2 (facilitated glucose NM_011400 transporter), member 1 (Slc2a1), mRNA.

6873217 -1.4544 0.000123 Got1 glutamate oxaloacetate transaminase 1, NM_010324 soluble (Got1), mRNA. 6784054 -1.45529 3.46E-05 Cdc6 cell division cycle 6 homolog (S. NM_011799 cerevisiae) (Cdc6), transcript variant 1, mRNA. 6761691 -1.45544 0.000585 Dbi diazepam binding inhibitor (Dbi), transcript NM_001037999 variant 1, mRNA. 6867677 -1.45549 4.5E-07 Pcx pyruvate carboxylase (Pcx), nuclear gene NM_001162946 encoding mitochondrial protein, transcript variant 1, mRNA. 6780933 -1.4619 4.11E-05 Vdac1 voltage-dependent anion channel 1 NM_011694 (Vdac1), nuclear gene encoding mitochondrial protein, mRNA. 6769033 -1.46298 3.88E-07 Icosl icos ligand (Icosl), mRNA. NM_015790 6871457 -1.46883 5.98E-05 Incenp inner centromere protein (Incenp), mRNA. NM_016692

6946778 -1.47307 1.62E-05 Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) NM_019499 (Mad2l1), mRNA. 6784062 -1.4732 0.000449 Igfbp4 insulin-like growth factor binding protein 4 NM_010517 (Igfbp4), mRNA. 6755207 -1.47326 0.000349 Slamf1 signaling lymphocytic activation molecule NM_013730 family member 1 (Slamf1), mRNA.

6825544 -1.47503 6.06E-06 Cdca2 cell division cycle associated 2 (Cdca2), NM_001110162 transcript variant 1, mRNA. 6966600 -1.47965 1.72E-05 Ccne1 cyclin E1 (Ccne1), mRNA. NM_007633 6847338 -1.48138 0.00011 D16Ertd472e DNA segment, Chr 16, ERATO Doi 472, NM_025967 expressed (D16Ertd472e), mRNA. 6876205 -1.48435 9.19E-07 Fam102a family with sequence similarity 102, NM_153560 member A (Fam102a), mRNA. 6779373 -1.4862 4.37E-05 Xpo1 exportin 1, CRM1 homolog (yeast) (Xpo1), NM_134014 transcript variant 1, mRNA. 6913042 -1.48832 3.47E-05 Glipr2 GLI pathogenesis-related 2 (Glipr2), NM_027450 mRNA. 6880468 -1.49017 2.74E-05 D2Ertd750e DNA segment, Chr 2, ERATO Doi 750, NM_026412 expressed (D2Ertd750e), mRNA. 6955025 -1.49455 6.52E-06 Mthfd2 methylenetetrahydrofolate dehydrogenase NM_008638 (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (Mthfd2), nuclear gene encoding mitochondrial protein, mRNA. 6944982 -1.49461 2.43E-05 2310016C08Ri RIKEN cDNA 2310016C08 gene NM_023516 k (2310016C08Rik), transcript variant 2, mRNA. 6777955 -1.49749 0.000117 Shmt2 serine hydroxymethyltransferase 2 NM_028230 (mitochondrial) (Shmt2), nuclear gene encoding mitochondrial protein, mRNA. 6783810 -1.50064 0.005128 Snf8 SNF8, ESCRT-II complex subunit, NM_033568 homolog (S. cerevisiae) (Snf8), mRNA. 6855087 -1.50179 2.08E-05 Tnf tumor necrosis factor (Tnf), mRNA. NM_013693 6820047 -1.50195 6.44E-07 Tnfrsf10b tumor necrosis factor receptor superfamily, NM_020275 member 10b (Tnfrsf10b), mRNA.

6773633 -1.50441 0.000333 Aim1 absent in melanoma 1 (Aim1), mRNA. NM_172393 6871361 -1.50494 0.00016 Slc3a2 solute carrier family 3 (activators of dibasic NM_001161413 and neutral amino acid transport), member 2 (Slc3a2), transcript variant 1, mRNA.

6899221 -1.50674 2.27E-07 Krtcap2 keratinocyte associated protein 2 NM_025327 (Krtcap2), mRNA. 6977712 -1.50759 6.45E-07 Podnl1 podocan-like 1 (Podnl1), mRNA. NM_001013384 7015011 -1.50771 3.94E-07 Piga phosphatidylinositol glycan anchor NM_011081 biosynthesis, class A (Piga), mRNA. 6933283 -1.51418 2.15E-05 1700013N18Ri RIKEN cDNA 1700013N18 gene NR_003639 k (1700013N18Rik), non-coding RNA. 6843913 -1.51528 4.2E-05 Socs1 suppressor of cytokine signaling 1 (Socs1), NM_009896 mRNA. 6992022 -1.51914 3.29E-05 Topbp1 topoisomerase (DNA) II binding protein 1 NM_176979 (Topbp1), mRNA. 6963049 -1.52342 0.000361 Rrm1 ribonucleotide reductase M1 (Rrm1), NM_009103 mRNA. 6787035 -1.52463 1.65E-06 Stc2 stanniocalcin 2 (Stc2), mRNA. NM_011491 6946396 -1.52934 0.000105 Gars glycyl-tRNA synthetase (Gars), mRNA. NM_180678 6842273 -1.52938 0.000415 Gbe1 glucan (1,4-alpha-), branching enzyme 1 NM_028803 (Gbe1), mRNA. 6812375 -1.53013 6.71E-05 Nrn1 neuritin 1 (Nrn1), mRNA. NM_153529 6993722 -1.53218 1.87E-05 Dnmt1 DNA methyltransferase (cytosine-5) 1 NM_010066 (Dnmt1), mRNA. 6755242 -1.53364 0.000686 Ccdc19 coiled-coil domain containing 19 (Ccdc19), NM_027972 mRNA. 6810782 -1.53462 7E-07 Pfkp phosphofructokinase, platelet (Pfkp), NM_019703 mRNA. 6858868 -1.53477 1.92E-05 Rbbp8 retinoblastoma binding protein 8 (Rbbp8), NM_001081223 mRNA. 6899622 -1.53686 0.001748 Selenbp1 selenium binding protein 1 (Selenbp1), NM_009150 mRNA. 6777073 -1.54068 2.35E-05 Glipr1 GLI pathogenesis-related 1 (glioma) NM_028608 (Glipr1), mRNA. 6995190 -1.54111 0.000983 Il10ra interleukin 10 receptor, alpha (Il10ra), NM_008348 mRNA. 6794307 -1.54195 0.00051 Sypl synaptophysin-like protein (Sypl), transcript NM_013635 variant 1, mRNA. 6770160 -1.54607 1.13E-05 Dusp6 dual specificity phosphatase 6 (Dusp6), NM_026268 mRNA. 6795455 -1.54825 3.29E-05 Ctage5 CTAGE family, member 5 (Ctage5), NM_146034 transcript variant 1, mRNA. 6764007 -1.54845 4.38E-07 Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 NM_010476 (Hsd17b7), mRNA. 6792699 -1.54928 0.001103 Eif4a3 eukaryotic translation initiation factor 4A3 NM_138669 (Eif4a3), mRNA. 6970393 -1.55281 9.57E-05 Dennd5a DENN/MADD domain containing 5A NM_021494 (Dennd5a), mRNA. 6957252 -1.5674 2.07E-06 Rad51ap1 RAD51 associated protein 1 (Rad51ap1), NM_009013 mRNA. 6781970 -1.57027 7.79E-05 Aurkb aurora kinase B (Aurkb), mRNA. NM_011496 6806034 -1.57179 7.54E-06 Serpinb6b serine (or cysteine) peptidase inhibitor, NM_011454 clade B, member 6b (Serpinb6b), mRNA.

6806963 -1.57273 9.54E-06 Iars isoleucine-tRNA synthetase (Iars), mRNA. NM_172015

6873069 -1.57448 0.000122 Aldh18a1 aldehyde dehydrogenase 18 family, NM_019698 member A1 (Aldh18a1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. 6856239 -1.57782 7.37E-06 Lonp1 lon peptidase 1, mitochondrial (Lonp1), NM_028782 nuclear gene encoding mitochondrial protein, mRNA. 6805794 -1.57796 1.91E-07 Mboat1 membrane bound O-acyltransferase NM_153546 domain containing 1 (Mboat1), mRNA. 6901187 -1.57905 1.5E-07 4930422G04Ri RIKEN cDNA 4930422G04 gene NM_197997 k (4930422G04Rik), mRNA. 6863048 -1.57946 0.001054 Map3k8 mitogen-activated protein kinase kinase NM_007746 kinase 8 (Map3k8), mRNA. 6813242 -1.5817 7.59E-06 Auh AU RNA binding protein/enoyl-coenzyme A NM_016709 hydratase (Auh), nuclear gene encoding mitochondrial protein, mRNA. 6873150 -1.58663 4.61E-05 Arhgap19 Rho GTPase activating protein 19 NM_027667 (Arhgap19), transcript variant 1, mRNA. 6771560 -1.58766 5.14E-05 Ddit3 DNA-damage inducible transcript 3 (Ddit3), NM_007837 mRNA. 6941649 -1.58933 1.41E-06 Oas3 2'-5' oligoadenylate synthetase 3 (Oas3), NM_145226 mRNA. 6792779 -1.59014 2E-06 P4hb prolyl 4-hydroxylase, beta polypeptide NM_011032 (P4hb), mRNA. 6841136 -1.59047 1.96E-05 Cd200r1 CD200 receptor 1 (Cd200r1), mRNA. NM_021325 6796799 -1.59072 0.000166 1810035L17Ri RIKEN cDNA 1810035L17 gene NM_026958 k (1810035L17Rik), mRNA. 6911682 -1.59077 0.000156 Ccne2 cyclin E2 (Ccne2), transcript variant 2, NM_009830 mRNA. 6930864 -1.59158 0.000208 Rbpj recombination signal binding protein for NM_009035 immunoglobulin kappa J region (Rbpj), transcript variant 1, mRNA. 6919200 -1.59188 2.83E-06 Fam132a family with sequence similarity 132, NM_026125 member A (Fam132a), mRNA. 6799897 -1.59435 2.15E-05 Pik3cg phosphoinositide-3-kinase, catalytic, NM_020272 gamma polypeptide (Pik3cg), transcript variant 1, mRNA. 6975367 -1.59604 2.67E-06 Ppp1r3b protein phosphatase 1, regulatory NM_177741 (inhibitor) subunit 3B (Ppp1r3b), mRNA. 6864529 -1.60568 2.07E-06 Cdc25c cell division cycle 25 homolog C (S. NM_009860 pombe) (Cdc25c), mRNA. 6838730 -1.60585 3.28E-06 Aaas achalasia, adrenocortical insufficiency, NM_153416 alacrimia (Aaas), mRNA. 6788293 -1.60707 7.09E-06 Rad50 RAD50 homolog (S. cerevisiae) (Rad50), NM_009012 mRNA. 6797434 -1.60777 3.48E-08 9030617O03Ri RIKEN cDNA 9030617O03 gene, mRNA BC021385 k (cDNA clone MGC:29259 IMAGE:5064508), complete cds. 6966903 -1.60821 8.9E-08 Atf5 activating transcription factor 5 (Atf5), NM_030693 transcript variant 1, mRNA. 6880497 -1.61168 2.54E-05 Rad51 RAD51 homolog (S. cerevisiae) (Rad51), NM_011234 mRNA. 6934584 -1.61371 0.001927 Ran RAN, member RAS oncogene family NM_009391 (Ran), mRNA. 6863002 -1.61416 1.01E-05 Crem cAMP responsive element modulator NM_001110859 (Crem), transcript variant 1, mRNA. 6961896 -1.61653 6.96E-06 Isg20 interferon-stimulated protein (Isg20), NM_020583 transcript variant 1, mRNA. 6953331 -1.61681 5.74E-07 Ezh2 enhancer of zeste homolog 2 (Drosophila) NM_007971 (Ezh2), transcript variant 1, mRNA.

6787474 -1.61983 3.56E-06 Ccng1 cyclin G1 (Ccng1), mRNA. NM_009831 6928939 -1.62481 2.02E-05 Hgf hepatocyte growth factor (Hgf), mRNA. NM_010427 6815271 -1.63118 5.31E-05 F2r coagulation factor II (thrombin) receptor NM_010169 (F2r), mRNA. 6897002 -1.63452 6.91E-05 Plk4 polo-like kinase 4 (Drosophila) (Plk4), NM_011495 mRNA. 6836358 -1.63931 1.67E-06 Ndrg1 N-myc downstream regulated gene 1 NM_008681 (Ndrg1), mRNA. 6871471 -1.64483 0.000535 Fads2 fatty acid desaturase 2 (Fads2), mRNA. NM_019699 6854604 -1.64517 4.64E-05 Fkbp5 FK506 binding protein 5 (Fkbp5), mRNA. NM_010220

6977696 -1.64604 0.000245 Asf1b ASF1 anti-silencing function 1 homolog B NM_024184 (S. cerevisiae) (Asf1b), mRNA. 6805825 -1.64647 0.000417 Irf4 interferon regulatory factor 4 (Irf4), mRNA. NM_013674

6892139 -1.64957 9.1E-07 Trib3 tribbles homolog 3 (Drosophila) (Trib3), NM_175093 mRNA. 6980032 -1.65215 0.000173 Itgb1 integrin beta 1 (fibronectin receptor beta) NM_010578 (Itgb1), mRNA. 7013857 -1.65424 3.93E-06 Cenpi centromere protein I (Cenpi), mRNA. NM_145924 6921375 -1.65825 5.7E-07 Hemgn hemogen (Hemgn), mRNA. NM_053149 6885869 -1.65842 0.002371 2900010J23Ri RIKEN cDNA 2900010J23 gene NM_175190 k (2900010J23Rik), mRNA. 6977261 -1.66552 9.58E-05 Mcm5 minichromosome maintenance deficient 5, NM_008566 cell division cycle 46 (S. cerevisiae) (Mcm5), mRNA. 6878713 -1.66781 5.27E-05 Slc43a3 solute carrier family 43, member 3 NM_021398 (Slc43a3), mRNA. 6972410 -1.6688 2.86E-07 Cars cysteinyl-tRNA synthetase (Cars), mRNA. NM_013742

6833394 -1.67491 8.15E-06 Soat2 sterol O-acyltransferase 2 (Soat2), mRNA. NM_146064

6867830 -1.68307 1.53E-05 Cdca5 cell division cycle associated 5 (Cdca5), NM_026410 mRNA. 6815305 -1.68332 2.78E-05 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A NM_008255 reductase (Hmgcr), mRNA. 6757282 -1.68561 5.36E-05 Mcm3 minichromosome maintenance deficient 3 NM_008563 (S. cerevisiae) (Mcm3), mRNA. 6890658 -1.68696 3.38E-05 Ncaph non-SMC condensin I complex, subunit H NM_144818 (Ncaph), mRNA. 6988627 -1.68858 0.00065 H2afx H2A histone family, member X (H2afx), NM_010436 mRNA. 6791504 -1.68986 5.47E-07 Brca1 breast cancer 1 (Brca1), mRNA. NM_009764 6796492 -1.69316 6.49E-06 Sipa1l1 signal-induced proliferation-associated 1 NM_001167983 like 1 (Sipa1l1), transcript variant 2, mRNA.

6859411 -1.69399 5.67E-08 Mapre2 microtubule-associated protein, RP/EB NM_153058 family, member 2 (Mapre2), transcript variant 1, mRNA. 6805462 -1.69429 3.91E-10 Gpld1 glycosylphosphatidylinositol specific NM_008156 phospholipase D1 (Gpld1), mRNA. 6957162 -1.69663 4.03E-05 Ncapd2 non-SMC condensin I complex, subunit D2 NM_146171 (Ncapd2), mRNA. 6785307 -1.69993 7.67E-05 Birc5 baculoviral IAP repeat-containing 5 (Birc5), NM_001012273 transcript variant 3, mRNA. 6953443 -1.70037 5.22E-10 Igf2bp3 insulin-like growth factor 2 mRNA binding NM_023670 protein 3 (Igf2bp3), mRNA. 6966958 -1.71203 2.08E-05 Dkkl1 dickkopf-like 1 (Dkkl1), mRNA. NM_015789 6809812 -1.71238 1.44E-06 Cenpk centromere protein K (Cenpk), transcript NM_021790 variant 1, mRNA. 6786044 -1.71293 7.76E-06 Fignl1 fidgetin-like 1 (Fignl1), transcript variant 1, NM_001163359 mRNA. 6776029 -1.71348 4.9E-05 Nedd1 neural precursor cell expressed, NM_008682 developmentally down-regulated gene 1 (Nedd1), mRNA. 6889894 -1.71454 1.37E-06 Arhgap11a Rho GTPase activating protein 11A NM_181416 (Arhgap11a), mRNA. 6833980 -1.71604 6.74E-07 Rai14 retinoic acid induced 14 (Rai14), transcript NM_001166408 variant 2, mRNA. 6963898 -1.72333 8.13E-06 2610020H08Ri RIKEN cDNA 2610020H08 gene NM_028129 k (2610020H08Rik), transcript variant 2, mRNA. 6992174 -1.72401 0.000523 Rpl29 ribosomal protein L29 (Rpl29), mRNA. NM_009082 6803102 -1.73348 5.73E-06 Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 NM_153587 (Rps6ka5), mRNA. 6850191 -1.73791 0.000354 Ier3 immediate early response 3 (Ier3), mRNA. NM_133662

6825302 -1.74079 7.53E-06 Fdft1 farnesyl diphosphate farnesyl transferase 1 NM_010191 (Fdft1), mRNA. 6888296 -1.74395 0.000195 Calcrl calcitonin receptor-like (Calcrl), mRNA. NM_018782 6904047 -1.75159 5.82E-06 Zmat3 zinc finger matrin type 3 (Zmat3), mRNA. NM_009517

6749701 -1.75394 6.84E-06 Sgol2 shugoshin-like 2 (S. pombe) (Sgol2), NM_199007 transcript variant 1, mRNA. 6994666 -1.75496 9.91E-07 Chek1 checkpoint kinase 1 homolog (S. pombe) NM_007691 (Chek1), mRNA. 6880451 -1.75697 3.27E-05 Bub1b budding uninhibited by benzimidazoles 1 NM_009773 homolog, beta (S. cerevisiae) (Bub1b), mRNA. 6917496 -1.76028 2.19E-05 Sesn2 sestrin 2 (Sesn2), mRNA. NM_144907 6982921 -1.76493 4.62E-06 Sc4mol sterol-C4-methyl oxidase-like (Sc4mol), NM_025436 mRNA. 6964033 -1.76542 6.5E-05 Plk1 polo-like kinase 1 (Drosophila) (Plk1), NM_011121 mRNA. 6778463 -1.77046 1.68E-05 Xbp1 X-box binding protein 1 (Xbp1), mRNA. NM_013842 6773655 -1.771 4.53E-10 Prdm1 PR domain containing 1, with ZNF domain NM_007548 (Prdm1), mRNA. 6884155 -1.77206 1.89E-11 Slco4a1 solute carrier organic anion transporter NM_148933 family, member 4a1 (Slco4a1), mRNA. 6970911 -1.77594 2.14E-06 Eri2 exoribonuclease 2 (Eri2), mRNA. NM_027698 6765235 -1.77754 5.16E-07 Dtl denticleless homolog (Drosophila) (Dtl), NM_029766 mRNA. 6980944 -1.77782 3.07E-06 Ckap2 cytoskeleton associated protein 2 (Ckap2), NM_001004140 mRNA. 6830761 -1.77806 4.19E-07 Sqle squalene epoxidase (Sqle), mRNA. NM_009270 6917283 -1.78147 2.38E-05 Yars tyrosyl-tRNA synthetase (Yars), mRNA. NM_134151 6869932 -1.78226 6.5E-06 Scd2 stearoyl-Coenzyme A desaturase 2 (Scd2), NM_009128 mRNA. 6831994 -1.78268 2.88E-06 Atf4 activating transcription factor 4 (Atf4), NM_009716 mRNA. 6980158 -1.7831 0.000187 Shcbp1 Shc SH2-domain binding protein 1 NM_011369 (Shcbp1), mRNA. 6884642 -1.78428 1.84E-05 Gata3 GATA binding protein 3 (Gata3), mRNA. NM_008091 6763972 -1.79074 5.13E-05 Nuf2 NUF2, NDC80 kinetochore complex NM_023284 component, homolog (S. cerevisiae) (Nuf2), mRNA. 6856096 -1.79394 3.09E-05 Sgol1 shugoshin-like 1 (S. pombe) (Sgol1), NM_028232 mRNA. 6935927 -1.79423 1.44E-05 Cyp51 cytochrome P450, family 51 (Cyp51), NM_020010 mRNA. 6775830 -1.79485 1.55E-05 4930547N16Ri RIKEN cDNA 4930547N16 gene NM_029249 k (4930547N16Rik), mRNA. 6933422 -1.79491 3.19E-06 Pole polymerase (DNA directed), epsilon (Pole), NM_011132 mRNA. 6986648 -1.79763 3.92E-07 Casp1 caspase 1 (Casp1), mRNA. NM_009807 6785508 -1.80189 3.96E-06 Slc16a3 solute carrier family 16 (monocarboxylic NM_001038653 acid transporters), member 3 (Slc16a3), mRNA. 6911719 -1.80371 6.05E-07 Rad54b RAD54 homolog B (S. cerevisiae) NM_001039556 (Rad54b), mRNA. 6824846 -1.80392 1.55E-07 Ripk3 receptor-interacting serine-threonine NM_001164108 kinase 3 (Ripk3), transcript variant 3, mRNA. 6761256 -1.80666 1.53E-06 Bcl2 B-cell leukemia/lymphoma 2 (Bcl2), NM_009741 transcript variant 1, mRNA. 6968314 -1.81699 0.000583 Mctp2 multiple C2 domains, transmembrane 2 NM_001024703 (Mctp2), mRNA. 6962491 -1.81754 6.54E-06 Sytl2 synaptotagmin-like 2 (Sytl2), transcript NM_001040085 variant 2, mRNA. 6932517 -1.81774 4.83E-05 11-Sep septin 11 (Sept11), mRNA. NM_001009818 6871270 -1.81953 4.79E-05 Fkbp2 FK506 binding protein 2 (Fkbp2), transcript NM_008020 variant 1, mRNA. 6875038 -1.82307 0.000471 Il2ra interleukin 2 receptor, alpha chain (Il2ra), NM_008367 mRNA. 6933014 -1.82367 1.3E-08 Ptpn13 protein tyrosine phosphatase, non-receptor NM_011204 type 13 (Ptpn13), mRNA. 7018897 -1.82599 2.64E-06 Hmgn5 high-mobility group nucleosome binding NM_016710 domain 5 (Hmgn5), mRNA. 6781605 -1.82765 2.41E-07 Trim16 tripartite motif-containing 16 (Trim16), NM_053169 mRNA. 6756394 -1.82939 5.08E-05 Nek2 NIMA (never in mitosis gene a)-related NM_010892 expressed kinase 2 (Nek2), mRNA. 6891880 -1.82947 2.24E-06 Cd93 CD93 antigen (Cd93), mRNA. NM_010740 6974850 -1.83193 6.37E-07 Eif4ebp1 eukaryotic translation initiation factor 4E NM_007918 binding protein 1 (Eif4ebp1), mRNA. 6970916 -1.83439 7.02E-07 Dcun1d3 DCN1, defective in cullin neddylation 1, NM_173408 domain containing 3 (S. cerevisiae) (Dcun1d3), transcript variant 1, mRNA. 7018220 -1.83645 7.99E-06 Pola1 polymerase (DNA directed), alpha 1 NM_008892 (Pola1), mRNA. 6993154 -1.84101 0.000256 Ccr5 chemokine (C-C motif) receptor 5 (Ccr5), NM_009917 mRNA. 6811370 -1.84706 1.87E-06 Gpr141 G protein-coupled receptor 141 (Gpr141), NM_181754 mRNA. 6924834 -1.84792 0.000141 Kif2c kinesin family member 2C (Kif2c), mRNA. NM_134471

6887520 -1.84957 3.93E-05 Spc25 SPC25, NDC80 kinetochore complex NM_025565 component, homolog (S. cerevisiae) (Spc25), mRNA. 6929816 -1.85073 6.69E-06 Tacc3 transforming, acidic coiled-coil containing NM_001040435 protein 3 (Tacc3), mRNA. 6830638 -1.8583 3.47E-08 Wdr67 WD repeat domain 67 (Wdr67), transcript NM_001081396 variant 1, mRNA. 6857183 -1.85957 3.15E-05 Xdh xanthine dehydrogenase (Xdh), mRNA. NM_011723 6861700 -1.86169 1.01E-05 Impa2 inositol (myo)-1(or 4)-monophosphatase 2 NM_053261 (Impa2), mRNA. 6957133 -1.86605 1.26E-05 Tpi1 triosephosphate isomerase 1 (Tpi1), NM_009415 mRNA. 6925254 -1.8738 9.68E-06 Cdca8 cell division cycle associated 8 (Cdca8), NM_026560 mRNA. 6832394 -1.87645 4.45E-07 Gtse1 G two S phase expressed protein 1 NM_013882 (Gtse1), transcript variant 2, mRNA. 6774264 -1.87839 1.28E-06 Ddit4 DNA-damage-inducible transcript 4 (Ddit4), NM_029083 mRNA. 6836728 -1.88026 0.002925 Ly6a // Ly6a lymphocyte antigen 6 complex, locus A NM_010738 (Ly6a), mRNA. 6762024 -1.88093 5.92E-05 Cxcr4 chemokine (C-X-C motif) receptor 4 NM_009911 (Cxcr4), mRNA. 6964160 -1.88255 3.03E-05 Il4ra interleukin 4 receptor, alpha (Il4ra), mRNA. NM_001008700

6784578 -1.88801 1.24E-06 Tanc2 tetratricopeptide repeat, ankyrin repeat and NM_181071 coiled-coil containing 2 (Tanc2), mRNA.

6869035 -1.89198 3.66E-05 Pdcd1lg2 programmed cell death 1 ligand 2 NM_021396 (Pdcd1lg2), mRNA. 6957789 -1.89286 3.78E-10 Eps8 epidermal growth factor receptor pathway NM_007945 substrate 8 (Eps8), mRNA. 6957051 -1.89716 7.4E-06 Slc2a3 solute carrier family 2 (facilitated glucose NM_011401 transporter), member 3 (Slc2a3), mRNA.

6990948 -1.8998 5.53E-08 Ttk Ttk protein kinase (Ttk), transcript variant NM_009445 1, mRNA. 6962745 -1.90265 7.76E-08 Gab2 growth factor receptor bound protein 2- NM_010248 associated protein 2 (Gab2), transcript variant 1, mRNA. 6996267 -1.90768 5.14E-06 Zwilch Zwilch, kinetochore associated, homolog NM_026507 (Drosophila) (Zwilch), mRNA. 6979123 -1.9084 1.12E-06 Aars alanyl-tRNA synthetase (Aars), mRNA. NM_146217 6802745 -1.91693 3.55E-10 Ston2 stonin 2 (Ston2), mRNA. NM_175367 6765519 -1.92265 5.43E-06 Fbxo5 F-box protein 5 (Fbxo5), mRNA. NM_025995 6864565 -1.9266 1.74E-05 Hspa9 heat shock protein 9 (Hspa9), nuclear gene NM_010481 encoding mitochondrial protein, mRNA. 6791644 -1.9304 3.98E-06 Kif18b kinesin family member 18B (Kif18b), NM_197959 mRNA. 6989874 -1.93048 4.78E-05 Tipin timeless interacting protein (Tipin), mRNA. NM_025372

6949814 -1.93051 3.91E-05 Cdca3 cell division cycle associated 3 (Cdca3), NM_013538 mRNA. 6818647 -1.93255 5.59E-05 Cdkn3 cyclin-dependent kinase inhibitor 3 NM_028222 (Cdkn3), mRNA. 6899374 -1.93573 5.72E-06 S100a6 S100 calcium binding protein A6 (calcyclin) NM_011313 (S100a6), mRNA. 6871768 -1.93828 5.31E-06 Psat1 phosphoserine aminotransferase 1 NM_177420 (Psat1), mRNA. 6773368 -1.94031 1.2E-06 1700025K23Ri RIKEN cDNA 1700025K23 gene NM_183254 k (1700025K23Rik), mRNA. 6792601 -1.94641 7.09E-05 Tk1 thymidine kinase 1 (Tk1), mRNA. NM_009387 7010092 -1.94936 4.04E-05 Gpr34 G protein-coupled receptor 34 (Gpr34), NM_011823 mRNA. 6990416 -1.95258 9.47E-05 Nedd4 neural precursor cell expressed, NM_010890 developmentally down-regulated 4 (Nedd4), mRNA. 6917180 -1.95395 1.66E-06 Clspn claspin homolog (Xenopus laevis) (Clspn), NM_175554 mRNA. 6933697 -1.95651 1.74E-06 Cit citron (Cit), mRNA. NM_007708 6992209 -1.95695 8.66E-05 Cish cytokine inducible SH2-containing protein NM_009895 (Cish), mRNA. 6869577 -1.95712 3.15E-06 Hells helicase, lymphoid specific (Hells), mRNA. NM_008234

6845382 -1.96576 5.62E-06 Fam162a family with sequence similarity 162, NM_027342 member A (Fam162a), mRNA. 6875214 -1.96896 0.000144 Plxdc2 plexin domain containing 2 (Plxdc2), NM_026162 mRNA. 6784527 -1.96897 1.41E-05 Itgb3 integrin beta 3 (Itgb3), mRNA. NM_016780 6857078 -1.96994 3.07E-05 Ndc80 NDC80 homolog, kinetochore complex NM_023294 component (S. cerevisiae) (Ndc80), mRNA. 6780986 -1.9708 8.32E-07 Kif3a kinesin family member 3A (Kif3a), mRNA. NM_008443 6842009 -1.97109 4.61E-05 Pros1 protein S (alpha) (Pros1), mRNA. NM_011173 6923059 -1.98242 1.21E-06 Plin2 perilipin 2 (Plin2), mRNA. NM_007408 6753592 -1.98734 3.06E-05 Aspm asp (abnormal spindle)-like, microcephaly NM_009791 associated (Drosophila) (Aspm), mRNA.

6753273 -1.98988 9.8E-06 Cyb5r1 cytochrome b5 reductase 1 (Cyb5r1), NM_028057 mRNA. 6945611 -1.99394 7.34E-06 Rab19 RAB19, member RAS oncogene family NM_011226 (Rab19), mRNA. 6808314 -1.99698 0.000182 Glrx glutaredoxin (Glrx), mRNA. NM_053108 6841372 -1.99937 1.92E-05 C330027C09R RIKEN cDNA C330027C09 gene NM_172616 ik (C330027C09Rik), mRNA. 6794274 -2.00443 0.0001 2010109K11Ri RIKEN cDNA 2010109K11 gene NM_001162903 k (2010109K11Rik), mRNA. 6929719 -2.00548 9.11E-08 Fosl2 fos-like antigen 2 (Fosl2), mRNA. NM_008037 6967211 -2.00724 2.03E-05 E2f8 E2F transcription factor 8 (E2f8), mRNA. NM_001013368 6755896 -2.01633 1.32E-05 Dusp10 dual specificity phosphatase 10 (Dusp10), NM_022019 mRNA. 6989442 -2.02292 1.36E-06 Stra6 stimulated by retinoic acid gene 6 (Stra6), NM_009291 transcript variant 2, mRNA. 6811530 -2.02631 0.001101 Hist1h1b histone cluster 1, H1b (Hist1h1b), mRNA. NM_020034

7019640 -2.03007 1.97E-05 Morf4l2 mortality factor 4 like 2 (Morf4l2), transcript NM_001168225 variant 2, mRNA. 6880703 -2.0333 7.54E-05 AA467197 expressed sequence AA467197 NM_001004174 (AA467197), mRNA. 6869635 -2.03915 0.00014 Entpd1 ectonucleoside triphosphate NM_009848 diphosphohydrolase 1 (Entpd1), mRNA. 6911727 -2.04115 1.03E-06 Gem GTP binding protein (gene overexpressed NM_010276 in skeletal muscle) (Gem), mRNA.

6771620 -2.04384 3.86E-06 Prim1 DNA primase, p49 subunit (Prim1), mRNA. NM_008921

6805386 -2.04391 0.001684 Hist1h1a histone cluster 1, H1a (Hist1h1a), mRNA. NM_030609

6782691 -2.04424 2.87E-06 Spag5 sperm associated antigen 5 (Spag5), NM_017407 mRNA. 6760009 -2.04715 1.6E-07 Serpine2 serine (or cysteine) peptidase inhibitor, NM_009255 clade E, member 2 (Serpine2), mRNA. 6846105 -2.05239 5.37E-05 Trat1 T cell receptor associated transmembrane NM_198297 adaptor 1 (Trat1), mRNA.

6890835 -2.06086 2.48E-05 Ckap2l cytoskeleton associated protein 2-like NM_181589 (Ckap2l), mRNA. 6998614 -2.06778 2.68E-07 Hemk1 HemK methyltransferase family member 1 NM_133984 (Hemk1), mRNA. 6825436 -2.07038 4.31E-06 Esco2 establishment of cohesion 1 homolog 2 (S. NM_028039 cerevisiae) (Esco2), mRNA. 6758588 -2.07596 1.04E-06 Obfc2a oligonucleotide/oligosaccharide-binding NM_028696 fold containing 2A (Obfc2a), mRNA. 6919209 -2.07751 7.53E-05 Tnfrsf4 tumor necrosis factor receptor superfamily, NM_011659 member 4 (Tnfrsf4), mRNA. 6756790 -2.07798 1.62E-09 Mybl1 myeloblastosis oncogene-like 1 (Mybl1), NM_008651 mRNA. 6765218 -2.07927 3.94E-07 Atf3 activating transcription factor 3 (Atf3), NM_007498 mRNA. 6764694 -2.08091 9.45E-06 Enah enabled homolog (Drosophila) (Enah), NM_010135 transcript variant 1, mRNA. 6869370 -2.08342 2.02E-07 Kif20b kinesin family member 20B (Kif20b), NM_183046 mRNA. 6982550 -2.08815 7.03E-05 Neil3 nei like 3 (E. coli) (Neil3), mRNA. NM_146208 6950070 -2.09195 6.99E-06 Foxm1 forkhead box M1 (Foxm1), mRNA. NM_008021 6949202 -2.09253 3.29E-09 Pparg peroxisome proliferator activated receptor NM_001127330 gamma (Pparg), transcript variant 1, mRNA. 6916190 -2.09479 9.59E-09 Orc1 origin recognition complex, subunit 1 NM_011015 (Orc1), transcript variant A, mRNA. 6748883 -2.12315 1.21E-06 Il1r2 interleukin 1 receptor, type II (Il1r2), NM_010555 mRNA. 6780551 -2.13601 2.96E-06 Havcr2 hepatitis A virus cellular receptor 2 NM_134250 (Havcr2), mRNA. 6987403 -2.1425 3.66E-08 Ldlr low density lipoprotein receptor (Ldlr), NM_010700 mRNA. 6887286 -2.14677 5.03E-09 Cobll1 Cobl-like 1 (Cobll1), transcript variant 1, NM_177025 mRNA. 6948906 -2.15101 5.03E-07 Itpr1 inositol 1,4,5-triphosphate receptor 1 NM_010585 (Itpr1), mRNA. 6903753 -2.15242 6.19E-06 Ect2 ect2 oncogene (Ect2), transcript variant 1, NM_007900 mRNA. 6890715 -2.15263 3.14E-05 Bub1 budding uninhibited by benzimidazoles 1 NM_001113179 homolog (S. cerevisiae) (Bub1), transcript variant 1, mRNA. 6790475 -2.15429 4.58E-07 Brip1 BRCA1 interacting protein C-terminal NM_178309 helicase 1 (Brip1), mRNA. 6824346 -2.1621 3.24E-06 Dlgap5 discs, large (Drosophila) homolog- NM_144553 associated protein 5 (Dlgap5), transcript variant 1, mRNA. 6918900 -2.16492 3.66E-05 Tnfrsf9 tumor necrosis factor receptor superfamily, NM_011612 member 9 (Tnfrsf9), transcript variant 1, mRNA. 6768928 -2.16561 2.17E-10 Lss lanosterol synthase (Lss), mRNA. NM_146006 6826546 -2.166 4.99E-08 Diap3 diaphanous homolog 3 (Drosophila) NM_019670 (Diap3), mRNA. 6830481 -2.16657 0.000823 Nov nephroblastoma overexpressed gene NM_010930 (Nov), mRNA. 6851232 -2.17499 1.75E-05 Uhrf1 ubiquitin-like, containing PHD and RING NM_010931 finger domains, 1 (Uhrf1), transcript variant 1, mRNA. 6824974 -2.1977 9.73E-07 F630043A04Ri RIKEN cDNA F630043A04 gene NM_198605 k (F630043A04Rik), mRNA. 6880492 -2.20251 1.59E-05 Casc5 cancer susceptibility candidate 5 (Casc5), NM_029617 mRNA. 6962094 -2.20343 1.07E-05 Tm6sf1 transmembrane 6 superfamily member 1 NM_145375 (Tm6sf1), mRNA. 6774794 -2.20383 3.91E-06 Cdk1 cyclin-dependent kinase 1 (Cdk1), mRNA. NM_007659

6823011 -2.21007 1.87E-09 Kcnk5 potassium channel, subfamily K, member 5 NM_021542 (Kcnk5), mRNA. 6990067 -2.21721 0.00023 Rps27l ribosomal protein S27-like (Rps27l), NM_026467 mRNA. 6869537 -2.24873 7.99E-06 Cep55 centrosomal protein 55 (Cep55), transcript NM_001164362 variant 1, mRNA. 6993890 -2.24939 5.92E-07 Anln anillin, actin binding protein (Anln), mRNA. NM_028390

6942441 -2.26906 1.08E-09 Hip1 huntingtin interacting protein 1 (Hip1), NM_146001 mRNA. 6969429 -2.27519 2.95E-08 4632434I11Rik RIKEN cDNA 4632434I11 gene NM_001080995 (4632434I11Rik), mRNA. 6798403 -2.27651 4.37E-06 Ncapg2 non-SMC condensin II complex, subunit NM_133762 G2 (Ncapg2), mRNA. 6885287 -2.28476 1.28E-06 Mastl microtubule associated serine/threonine NM_025979 kinase-like (Mastl), mRNA. 6801335 -2.29325 8.09E-06 C79407 expressed sequence C79407 (C79407), NM_172578 mRNA. 6954982 -2.2951 1.34E-08 Hk2 hexokinase 2 (Hk2), mRNA. NM_013820 6800859 -2.30093 4.38E-07 Egln3 EGL nine homolog 3 (C. elegans) (Egln3), NM_028133 mRNA. 7012842 -2.31332 1.42E-05 Kif4 kinesin family member 4 (Kif4), mRNA. NM_008446 6904300 -2.32476 0.000226 Ccna2 cyclin A2 (Ccna2), mRNA. NM_009828 6913499 -2.32711 2.21E-06 Smc2 structural maintenance of chromosomes 2 NM_008017 (Smc2), mRNA. 6916483 -2.33607 3.32E-06 Stil Scl/Tal1 interrupting locus (Stil), mRNA. NM_009185 7015061 -2.34087 4.26E-08 Gpm6b glycoprotein m6b (Gpm6b), transcript NM_001177956 variant 2, mRNA. 6825872 -2.35311 2.29E-07 Cysltr2 cysteinyl leukotriene receptor 2 (Cysltr2), NM_133720 transcript variant 1, mRNA. 6924017 -2.35703 4.87E-08 Wdr78 WD repeat domain 78 (Wdr78), mRNA. NM_146254 6985361 -2.36162 7.22E-08 Mlkl mixed lineage kinase domain-like (Mlkl), NM_029005 mRNA. 6796699 -2.36279 2.94E-07 Batf basic leucine zipper transcription factor, NM_016767 ATF-like (Batf), mRNA. 6986649 -2.37264 1.01E-06 Casp4 caspase 4, apoptosis-related cysteine NM_007609 peptidase (Casp4), mRNA. 6764093 -2.37611 5.16E-06 Slamf7 SLAM family member 7 (Slamf7), mRNA. NM_144539

6848199 -2.38901 1.65E-05 Mx1 myxovirus (influenza virus) resistance 1 NR_003520 (Mx1), non-coding RNA. 6985900 -2.39354 2.92E-06 Slc7a5 solute carrier family 7 (cationic amino acid NM_011404 transporter, y+ system), member 5 (Slc7a5), mRNA. 6813742 -2.41082 1.9E-07 Ctla2b cytotoxic T lymphocyte-associated protein NM_001145801 2 beta (Ctla2b), transcript variant 2, mRNA.

6911537 -2.45626 2.2E-07 Chd7 chromodomain helicase DNA binding NM_001081417 protein 7 (Chd7), mRNA. 6978291 -2.46678 2.13E-06 Mt1 metallothionein 1 (Mt1), mRNA. NM_013602 6791298 -2.47884 3.94E-05 Top2a topoisomerase (DNA) II alpha (Top2a), NM_011623 mRNA. 7020371 -2.48189 0.000177 Prdx4 peroxiredoxin 4 (Prdx4), mRNA. NM_016764 6993098 -2.48323 6.6E-06 Kif15 kinesin family member 15 (Kif15), mRNA. NM_010620

6824878 -2.49146 9.15E-07 Gzmc granzyme C (Gzmc), mRNA. NM_010371 6996678 -2.49477 2.6E-06 Aqp9 aquaporin 9 (Aqp9), mRNA. NM_022026 6872739 -2.51572 1.41E-05 Lipo1 lipase, member O1 (Lipo1), mRNA. NM_001013770 6847823 -2.51882 2.19E-07 Gcfc1 GC-rich sequence DNA-binding factor 1 NM_026110 (Gcfc1), mRNA. 6788290 -2.52232 9.72E-08 Il4 interleukin 4 (Il4), transcript variant 1, NM_021283 mRNA. 6780995 -2.52613 2E-05 Il5 interleukin 5 (Il5), mRNA. NM_010558 6778391 -2.52743 1.19E-06 Lif leukemia inhibitory factor (Lif), transcript NM_008501 variant 1, mRNA. 6989974 -2.52936 0.000165 2810417H13Ri RIKEN cDNA 2810417H13 gene NM_026515 k (2810417H13Rik), mRNA. 6869503 -2.55245 2.85E-05 Kif11 kinesin family member 11 (Kif11), mRNA. NM_010615

6857065 -2.5633 1.18E-10 Emilin2 elastin microfibril interfacer 2 (Emilin2), NM_145158 mRNA. 6799462 -2.57843 2.27E-08 Id2 inhibitor of DNA binding 2 (Id2), mRNA. NM_010496 6990216 -2.58334 7.09E-07 Anxa2 annexin A2 (Anxa2), mRNA. NM_007585 6904330 -2.5836 9.13E-07 Cetn4 centrin 4 (Cetn4), mRNA. NM_145825 6975224 -2.60035 1.1E-08 Tex15 testis expressed gene 15 (Tex15), mRNA. NM_031374

6787469 -2.60147 1.04E-06 Hmmr hyaluronan mediated motility receptor NM_013552 (RHAMM) (Hmmr), mRNA. 6807041 -2.60711 2.71E-07 Gadd45g growth arrest and DNA-damage-inducible NM_011817 45 gamma (Gadd45g), mRNA. 6961987 -2.60743 5.7E-06 Prc1 protein regulator of cytokinesis 1 (Prc1), NM_145150 mRNA. 6919320 -2.61128 2.29E-05 Penk preproenkephalin (Penk), mRNA. NM_001002927 6872010 -2.61574 6.07E-07 Anxa1 annexin A1 (Anxa1), mRNA. NM_010730 6824206 -2.62173 1.58E-08 Ero1l ERO1-like (S. cerevisiae) (Ero1l), mRNA. NM_015774

6971848 -2.63715 0.000189 Mki67 antigen identified by monoclonal antibody NM_001081117 Ki 67 (Mki67), mRNA. 6865643 -2.65801 4.05E-07 Zfp608 zinc finger protein 608 (Zfp608), mRNA. NM_175751 6940358 -2.6748 0.000317 Plac8 placenta-specific 8 (Plac8), mRNA. NM_139198 6790538 -2.68332 7.95E-07 Prr11 proline rich 11 (Prr11), mRNA. NM_175563 6972106 -2.71106 1.16E-10 Adam8 a disintegrin and metallopeptidase domain NM_007403 8 (Adam8), mRNA. 6805380 -2.71909 0.0049 Hist1h2bb histone cluster 1, H2bb (Hist1h2bb), NM_175664 mRNA. 6829277 -2.75616 2.18E-10 Myo10 myosin X (Myo10), mRNA. NM_019472 6901592 -2.75695 6.94E-06 Cenpe centromere protein E (Cenpe), mRNA. NM_173762 6880529 -2.75903 1.3E-05 Nusap1 nucleolar and spindle associated protein 1 NM_133851 (Nusap1), transcript variant 1, mRNA. 6999129 -2.7628 4.95E-06 ------6996186 -2.79208 1.64E-06 Kif23 kinesin family member 23 (Kif23), mRNA. NM_024245

6928457 -2.85924 7.43E-08 Cdk6 cyclin-dependent kinase 6 (Cdk6), mRNA. NM_009873

6999130 -2.87859 0.000307 Ccr4 chemokine (C-C motif) receptor 4 (Ccr4), NM_009916 mRNA. 6951525 -2.99032 3.14E-08 Asns asparagine synthetase (Asns), mRNA. NM_012055 6906903 -2.99973 1.25E-06 S100a1 S100 calcium binding protein A1 (S100a1), NM_011309 mRNA. 6977042 -3.00489 8.99E-09 Il12rb1 interleukin 12 receptor, beta 1 (Il12rb1), NM_008353 mRNA. 6882333 -3.01191 2.97E-07 Tpx2 TPX2, microtubule-associated protein NM_001141977 homolog (Xenopus laevis) (Tpx2), transcript variant 1, mRNA. 7018804 -3.01386 1.93E-10 Cysltr1 cysteinyl leukotriene receptor 1 (Cysltr1), NM_021476 mRNA. 6781012 -3.01843 1.32E-10 P4ha2 procollagen-proline, 2-oxoglutarate 4- NM_001136076 dioxygenase (proline 4-hydroxylase), alpha II polypeptide (P4ha2), transcript variant 1, mRNA. 6905408 -3.01983 4.96E-06 P2ry14 purinergic receptor P2Y, G-protein NM_133200 coupled, 14 (P2ry14), transcript variant 1, mRNA. 6788291 -3.03335 4.62E-09 Il13 interleukin 13 (Il13), mRNA. NM_008355 6810166 -3.04594 2.12E-08 Plk2 polo-like kinase 2 (Drosophila) (Plk2), NM_152804 mRNA. 6892579 -3.06548 1.44E-07 Tgm2 transglutaminase 2, C polypeptide (Tgm2), NM_009373 mRNA. 6926655 -3.14011 1.52E-10 Tnfrsf8 tumor necrosis factor receptor superfamily, NM_009401 member 8 (Tnfrsf8), mRNA. 6907204 -3.25561 7.86E-08 Ecm1 extracellular matrix protein 1 (Ecm1), NM_007899 mRNA. 6954415 -3.25874 0.000115 Il12rb2 interleukin 12 receptor, beta 2 (Il12rb2), NM_008354 mRNA. 6805270 -3.31011 0.000855 Hist1h2bk histone cluster 1, H2bk (Hist1h2bk), NM_175665 mRNA. 6767782 -3.41845 5.73E-09 Lilrb4 leukocyte immunoglobulin-like receptor, NM_013532 subfamily B, member 4 (Lilrb4), mRNA. 6824873 -3.43591 1.61E-07 Gzmg granzyme G (Gzmg), mRNA. NM_010375 6824146 -3.50634 1.35E-08 5730469M10Ri RIKEN cDNA 5730469M10 gene, mRNA BC056635 k (cDNA clone MGC:68088 IMAGE:5064081), complete cds. 6813246 -3.62316 6.74E-10 Nfil3 nuclear factor, interleukin 3, regulated NM_017373 (Nfil3), mRNA. 6816160 -3.70674 0.000739 Gzma granzyme A (Gzma), mRNA. NM_010370 6809148 -3.727 1.47E-07 F2rl2 coagulation factor II (thrombin) receptor- NM_010170 like 2 (F2rl2), mRNA. 6978290 -3.75928 1.11E-06 Mt2 metallothionein 2 (Mt2), mRNA. NM_008630 6762123 -3.85923 3.02E-09 Il24 interleukin 24 (Il24), mRNA. NM_053095 6824871 -3.87393 8.25E-08 Gzmd granzyme D (Gzmd), mRNA. NM_010372 6972168 -3.90215 1.26E-07 Ifitm3 interferon induced transmembrane protein NM_025378 3 (Ifitm3), mRNA. 6767235 -4.02013 1.42E-09 Tube1 epsilon-tubulin 1 (Tube1), mRNA. NM_028006 6849595 -4.15062 5.46E-11 Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) NM_007669 (Cdkn1a), transcript variant 1, mRNA.

6989440 -4.18957 3.62E-12 Cyp11a1 cytochrome P450, family 11, subfamily a, NM_019779 polypeptide 1 (Cyp11a1), nuclear gene encoding mitochondrial protein, mRNA.

6852836 -4.3748 4.58E-15 Epas1 endothelial PAS domain protein 1 (Epas1), NM_010137 mRNA. 6824880 -5.1014 5.26E-07 Gzmb granzyme B (Gzmb), mRNA. NM_013542 6788329 -5.11631 9.66E-07 Csf2 colony stimulating factor 2 (granulocyte- NM_009969 macrophage) (Csf2), mRNA. Regateiro et al Supplementary Table II Probeset_id log ratio p-value Gene Symbol mRna - Description Gene Accession T/UT 6748837 0.646667 0.002614 Npas2 neuronal PAS domain protein 2 (Npas2), mRNA. NM_008719 6748883 -2.99333 0.003831 Il1r2 interleukin 1 receptor, type II (Il1r2), mRNA. NM_010555 6749376 1.246667 2.24E-05 Stat1 signal transducer and activator of transcription 1 (Stat1), mRNM_009283 6751264 0.6 0.00231 Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPasNM_027357 6752730 0.31 0.002845 Slc35f5 solute carrier family 35, member F5 (Slc35f5), mRNA. NM_028787 6753014 -5.11 0.000195 Il10 interleukin 10 (Il10), mRNA. NM_010548 6754519 -1.23 0.000777 Gas5 growth arrest specific 5 (Gas5), non-coding RNA. NR_002840 6754696 -1.68667 0.000529 Slc19a2 solute carrier family 19 (thiamine transporter), member 2 (SlNM_054087 6755216 1.313333 0.005267 Slamf6 SLAM family member 6 (Slamf6), mRNA. NM_030710 6755713 1.18 0.00639 Lefty1 left right determination factor 1 (Lefty1), mRNA. NM_010094 6755896 -2.05 0.000226 Dusp10 dual specificity phosphatase 10 (Dusp10), mRNA. NM_022019 6756346 -0.61 0.006214 Batf3 basic leucine zipper transcription factor, ATF-like 3 (Batf3), mNM_030060 6757120 -1.24 0.0001 Stau2 staufen (RNA binding protein) homolog 2 (Drosophila) (StauNM_025303 6757898 2.416667 0.003087 Neurl3 neuralized homolog 3 homolog (Drosophila) (Neurl3), mRNANM_153408 6758001 1.73 0.000352 Aff3 AF4/FMR2 family, member 3 (Aff3), mRNA. NM_010678 6758435 0.22 0.002337 Slc40a1 solute carrier family 40 (iron-regulated transporter), memberNM_016917 6758588 -1.89667 0.003212 Obfc2a oligonucleotide/oligosaccharide-binding fold containing 2A (ONM_028696 6759043 -0.65667 0.001364 Wdr12 WD repeat domain 12 (Wdr12), mRNA. NM_021312 6759549 3.256667 0.000165 Ikzf2 IKAROS family zinc finger 2 (Ikzf2), mRNA. NM_011770 6760009 -2.11667 0.004654 Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 ( NM_009255 6760042 0.9 0.002858 Fam124b family with sequence similarity 124, member B (Fam124b), NM_173425 6761139 -0.83 0.005547 Rnf152 ring finger protein 152 (Rnf152), transcript variant 1, mRNA.NM_178779 6762123 -4.13333 3.72E-05 Il24 interleukin 24 (Il24), mRNA. NM_053095 6762314 1.613333 0.006042 Lax1 lymphocyte transmembrane adaptor 1 (Lax1), transcript var NM_001159649 6763275 -0.7 0.009715 Fam20b family with sequence similarity 20, member B (Fam20b), mRNM_145413 6763493 -0.48667 0.003166 Cacybp calcyclin binding protein (Cacybp), mRNA. NM_009786 6763731 3.96 3.61E-05 Xcl1 chemokine (C motif) ligand 1 (Xcl1), mRNA. NM_008510 6764034 -0.44 0.005564 Fcrlb Fc receptor-like B (Fcrlb), mRNA. NM_001029984 6764205 -0.22667 0.00431 Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide (Fcer1a), mNM_010184 6764231 2.273333 0.00472 Pyhin1 pyrin and HIN domain family, member 1 (Pyhin1), mRNA. NM_175026 6764274 2.433333 0.004387 Ifi203 interferon activated gene 203 (Ifi203), transcript variant 1, mNM_001045481 6764526 1.57 0.004134 Smyd3 SET and MYND domain containing 3 (Smyd3), mRNA. NM_027188 6764650 1.606667 5.04E-05 Ephx1 epoxide hydrolase 1, microsomal (Ephx1), mRNA. NM_010145 6765218 -1.58667 0.002316 Atf3 activating transcription factor 3 (Atf3), mRNA. NM_007498 6765235 -1.03 0.009142 Dtl denticleless homolog (Drosophila) (Dtl), mRNA. NM_029766 6765275 1.296667 0.008048 Traf5 TNF receptor-associated factor 5 (Traf5), mRNA. NM_011633 6765474 0.406667 0.00455 Cnksr3 Cnksr family member 3 (Cnksr3), mRNA. NM_172546 6766110 1 0.001987 Hivep2 human immunodeficiency virus type I enhancer binding prot NM_010437 6766352 0.383333 0.00254 --- adult male epididymis cDNA, RIKEN full-length enriched libr --- 6766835 -0.63 0.001834 Ptprk protein tyrosine phosphatase, receptor type, K (Ptprk), mRNNM_008983 6767235 -3.54333 9.13E-06 Tube1 epsilon-tubulin 1 (Tube1), mRNA. NM_028006 6767468 0.946667 0.003444 Scml4 sex comb on midleg-like 4 (Drosophila) (Scml4), mRNA. NM_172938 6767537 -1.74333 0.005935 Cd24a CD24a antigen (Cd24a), mRNA. NM_009846 6767636 -1.71333 0.002255 Gpx4 glutathione peroxidase 4 (Gpx4), transcript variant 2, mRNANM_008162 6767782 -2.36667 9.49E-05 Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, memb NM_013532 6768076 1.943333 0.001545 Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A (Smpdl3a), mNM_020561 6768868 0.666667 0.003635 Ggt5 gamma-glutamyltransferase 5 (Ggt5), mRNA. NM_011820 6769033 -1.31 0.005031 Icosl icos ligand (Icosl), mRNA. NM_015790 6769445 0.896667 0.008858 Tcp11l2 t-complex 11 (mouse) like 2 (Tcp11l2), mRNA. NM_146008 6769481 1.88 0.002856 Btbd11 BTB (POZ) domain containing 11 (Btbd11), transcript varianNM_028709 6770030 0.96 0.002328 Btg1 B-cell translocation gene 1, anti-proliferative (Btg1), mRNA. NM_007569 6770160 -1.43333 0.005365 Dusp6 dual specificity phosphatase 6 (Dusp6), mRNA. NM_026268 6771995 1.74 0.003795 Ust uronyl-2-sulfotransferase (Ust), mRNA. NM_177387 6772193 0.886667 0.007531 Utrn utrophin (Utrn), mRNA. NM_011682 6772417 0.726667 0.002675 Tnfaip3 tumor necrosis factor, alpha-induced protein 3 (Tnfaip3), tra NM_001166402 6772594 -1.68333 0.003692 Myb myeloblastosis oncogene (Myb), mRNA. NM_010848 6773173 1.05 0.004301 Fam26f family with sequence similarity 26, member F (Fam26f), mR NM_175449 6773368 -1.99 0.001512 1700025K23Rik RIKEN cDNA 1700025K23 gene (1700025K23Rik), mRNA. NM_183254 6775146 0.31 0.009578 Susd2 sushi domain containing 2 (Susd2), transcript variant 1, mRNNM_027890 6775176 -0.18333 0.004764 A130042E20Rik RIKEN cDNA A130042E20 gene (A130042E20Rik), mRNA. NM_172550 6775182 -0.41667 0.004683 Col6a2 collagen, type VI, alpha 2 (Col6a2), mRNA. NM_146007 6776029 -1.46 0.002131 Nedd1 neural precursor cell expressed, developmentally down-reguNM_008682 6776156 -1.21667 0.002071 Plxnc1 plexin C1 (Plxnc1), mRNA. NM_018797 6776577 -0.89 0.000702 Nts neurotensin (Nts), mRNA. NM_024435 6776667 -1.53667 0.000459 Tmtc2 transmembrane and tetratricopeptide repeat containing 2 (T NM_177368 6777073 -1.78 0.000919 Glipr1 GLI pathogenesis-related 1 (glioma) (Glipr1), mRNA. NM_028608 6777286 1.186667 0.009427 Rab3ip RAB3A interacting protein (Rab3ip), mRNA. NM_001003950 6777309 1.633333 0.005295 Lyz2 lysozyme 2 (Lyz2), mRNA. NM_017372 6777346 -1.15667 0.009063 Mdm2 transformed mouse 3T3 cell double minute 2 (Mdm2), mRN NM_010786 6778057 0.8 0.00663 Dgka diacylglycerol kinase, alpha (Dgka), mRNA. NM_016811 6778284 1.606667 2.7E-05 Pik3ip1 phosphoinositide-3-kinase interacting protein 1 (Pik3ip1), m NM_178149 6778391 -1.93 0.005001 Lif leukemia inhibitory factor (Lif), transcript variant 1, mRNA. NM_008501 6778463 -1.27333 0.003302 Xbp1 X-box binding protein 1 (Xbp1), mRNA. NM_013842 6779827 1.003333 0.002361 Nsg2 neuron specific gene family member 2 (Nsg2), mRNA. NM_008741 6780983 -1.30667 0.00388 8-Sep septin 8 (Sept8), mRNA. NM_033144 6780986 -1.44667 0.004094 Kif3a kinesin family member 3A (Kif3a), mRNA. NM_008443 6781032 -0.83333 0.002925 Rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 (Rapgef6)NM_175258 6782286 4.573333 0.000228 Itgae integrin alpha E, epithelial-associated (Itgae), transcript variaNM_008399 6783840 -0.47 0.005442 Hoxb8 homeobox B8 (Hoxb8), mRNA. NM_010461 6784527 -1.83 0.002883 Itgb3 integrin beta 3 (Itgb3), mRNA. NM_016780 6784578 -1.70667 0.0019 Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil contaNM_181071 6785558 -1.11667 0.008177 Metrnl meteorin, glial cell differentiation regulator-like (Metrnl), mRNNM_144797 6786673 1.303333 0.001356 Rel reticuloendotheliosis oncogene (Rel), mRNA. NM_009044 6787474 -1.28667 0.000588 Ccng1 cyclin G1 (Ccng1), mRNA. NM_009831 6788020 -0.94333 0.000854 Canx calnexin (Canx), transcript variant 1, mRNA. NM_007597 6788172 2.34 0.001748 Tcf7 transcription factor 7, T-cell specific (Tcf7), mRNA. NM_009331 6788290 -2.78667 1.26E-05 Il4 interleukin 4 (Il4), transcript variant 1, mRNA. NM_021283 6788291 -3.96333 0.002102 Il13 interleukin 13 (Il13), mRNA. NM_008355 6788293 -1.24667 0.006242 Rad50 RAD50 homolog (S. cerevisiae) (Rad50), mRNA. NM_009012 6788329 -5.5 0.000127 Csf2 colony stimulating factor 2 (granulocyte-macrophage) (Csf2)NM_009969 6788333 -1.02333 0.005541 Il3 interleukin 3 (Il3), mRNA. NM_010556 6789279 0.22 0.005262 Tmem88 transmembrane protein 88 (Tmem88), mRNA. NM_025915 6789584 -0.40667 0.008508 Tmem93 transmembrane protein 93 (Tmem93), transcript variant 1, mNM_001168470 6790288 3.406667 0.000547 Ccl5 chemokine (C-C motif) ligand 5 (Ccl5), mRNA. NM_013653 6790531 1.496667 0.000471 Ypel2 yippee-like 2 (Drosophila) (Ypel2), mRNA. NM_001005341 6791015 0.703333 0.003663 Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2), mRNANM_133667 6791222 -0.88333 0.007992 Rpl23 ribosomal protein L23 (Rpl23), mRNA. NM_022891 6791230 1.223333 0.003575 Arl5c ADP-ribosylation factor-like 5C (Arl5c), mRNA. NM_207231 6791238 0.87 0.00068 Fbxl20 F-box and leucine-rich repeat protein 20 (Fbxl20), mRNA. NM_028149 6791310 2.446667 0.000489 Ccr7 chemokine (C-C motif) receptor 7 (Ccr7), mRNA. NM_007719 6791914 0.543333 0.009651 Cd79b CD79B antigen (Cd79b), mRNA. NM_008339 6792079 0.273333 0.005144 Rgs9 regulator of G-protein signaling 9 (Rgs9), transcript variant 1NM_011268 6792427 1.21 0.006048 C630004H02Rik RIKEN cDNA C630004H02 gene, mRNA (cDNA clone MGCBC024617 6792649 1.563333 0.004015 Timp2 tissue inhibitor of metalloproteinase 2 (Timp2), mRNA. NM_011594 6792650 0.366667 0.003589 Ddc8 differential display clone 8 (Ddc8), mRNA. NM_021440 6792779 -1.27333 0.007887 P4hb prolyl 4-hydroxylase, beta polypeptide (P4hb), mRNA. NM_011032 6792832 3.653333 0.000642 Cd7 CD7 antigen (Cd7), mRNA. NM_009854 6794307 -1.78 0.002543 Sypl synaptophysin-like protein (Sypl), transcript variant 1, mRNANM_013635 6795455 -1.6 0.003825 Ctage5 CTAGE family, member 5 (Ctage5), transcript variant 1, mRNM_146034 6796048 -1.35 0.000536 Hif1a hypoxia inducible factor 1, alpha subunit (Hif1a), mRNA. NM_010431 6796380 0.496667 0.005634 Actn1 actinin, alpha 1 (Actn1), mRNA. NM_134156 6796699 -1.98667 0.004908 Batf basic leucine zipper transcription factor, ATF-like (Batf), mR NM_016767 6797434 -1.45333 0.000244 9030617O03Rik RIKEN cDNA 9030617O03 gene, mRNA (cDNA clone MGCBC021385 6797714 0.466667 0.000759 Tcl1b2 T-cell leukemia/lymphoma 1B, 2 (Tcl1b2), mRNA. NM_013775 6797917 0.523333 0.005908 Evl Ena-vasodilator stimulated phosphoprotein (Evl), transcript vNM_001163394 6798392 1.24 0.005133 Vipr2 vasoactive intestinal peptide receptor 2 (Vipr2), mRNA. NM_009511 6799462 -2.12667 0.000832 Id2 inhibitor of DNA binding 2 (Id2), mRNA. NM_010496 6800079 0.916667 0.005969 Tspan13 tetraspanin 13 (Tspan13), mRNA. NM_025359 6800228 -1.14 0.003655 Arl4a ADP-ribosylation factor-like 4A (Arl4a), transcript variant 2, mNM_001039515 6802098 2.066667 0.001252 Actn1 actinin, alpha 1 (Actn1), mRNA. NM_134156 6802349 -0.91667 0.005398 Npc2 Niemann Pick type C2 (Npc2), mRNA. NM_023409 6802387 -0.86667 0.003219 Tmed10 transmembrane emp24-like trafficking protein 10 (yeast) (TmNM_026775 6802745 -1.57 0.008321 Ston2 stonin 2 (Ston2), mRNA. NM_175367 6803102 -1.46333 0.002688 Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 (Rps6ka5), mRNNM_153587 6803113 1.846667 0.004259 Gpr68 G protein-coupled receptor 68 (Gpr68), transcript variant 1, NM_175493 6805058 -0.88333 0.000132 2810021B07Rik RIKEN cDNA 2810021B07 gene (2810021B07Rik), mRNA. NM_025479 6805430 2.006667 0.003231 Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylaseNM_001111110 6805462 -1.50667 0.008249 Gpld1 glycosylphosphatidylinositol specific phospholipase D1 (GpldNM_008156 6805825 -1.52333 0.002655 Irf4 interferon regulatory factor 4 (Irf4), mRNA. NM_013674 6806073 -1.18667 0.00937 Nqo2 NAD(P)H dehydrogenase, quinone 2 (Nqo2), transcript variaNM_020282 6807041 -2.47667 0.004772 Gadd45g growth arrest and DNA-damage-inducible 45 gamma (GaddNM_011817 6807328 1.46 0.001648 Fbxl21 F-box and leucine-rich repeat protein 21 (Fbxl21), mRNA. NM_178674 6808215 0.47 0.004711 Tert telomerase reverse transcriptase (Tert), mRNA. NM_009354 6808221 1.296667 0.003399 Slc12a7 solute carrier family 12, member 7 (Slc12a7), mRNA. NM_011390 6808308 -1.38 0.004606 Ell2 elongation factor RNA polymerase II 2 (Ell2), mRNA. NM_138953 6808314 -1.60667 0.006866 Glrx glutaredoxin (Glrx), mRNA. NM_053108 6808876 2.143333 0.000301 Ssbp2 single-stranded DNA binding protein 2 (Ssbp2), transcript vaNM_024272 6808964 1.363333 0.008316 Serinc5 serine incorporator 5 (Serinc5), mRNA. NM_172588 6809148 -3.61667 7.47E-05 F2rl2 coagulation factor II (thrombin) receptor-like 2 (F2rl2), mRNANM_010170 6809272 -1.02 0.000725 Enc1 ectodermal-neural cortex 1 (Enc1), mRNA. NM_007930 6810166 -1.91 0.000456 Plk2 polo-like kinase 2 (Drosophila) (Plk2), mRNA. NM_152804 6810260 1.166667 0.001703 Il6st interleukin 6 signal transducer (Il6st), mRNA. NM_010560 6810548 1.716667 0.001458 Emb embigin (Emb), mRNA. NM_010330 6813246 -3.33667 0.000434 Nfil3 nuclear factor, interleukin 3, regulated (Nfil3), mRNA. NM_017373 6815268 1.443333 0.002342 F2rl1 coagulation factor II (thrombin) receptor-like 1 (F2rl1), mRNANM_007974 6815291 -1.02667 0.005588 Polk polymerase (DNA directed), kappa (Polk), mRNA. NM_012048 6816317 1.72 0.000415 Parp8 poly (ADP-ribose) polymerase family, member 8 (Parp8), m NM_001081009 6817217 -0.86667 0.006121 Thrb thyroid hormone receptor beta (Thrb), transcript variant 1, mNM_001113417 6817396 -1.64333 0.000878 Adk adenosine kinase (Adk), mRNA. NM_134079 6817694 0.446667 0.003549 Il17rd interleukin 17 receptor D (Il17rd), mRNA. NM_134437 6820047 -1.44667 7.22E-05 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b (TnNM_020275 6822946 1.3 0.000455 Nr1d2 nuclear receptor subfamily 1, group D, member 2 (Nr1d2), mNM_011584 6823721 1.22 0.006791 Sh3bp5 SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), mNM_011894 6824146 -3.07 0.000344 5730469M10Rik RIKEN cDNA 5730469M10 gene, mRNA (cDNA clone MGCBC056635 6824871 -4.89 0.003223 Gzmd granzyme D (Gzmd), mRNA. NM_010372 6824880 -2.47333 0.003796 Gzmb granzyme B (Gzmb), mRNA. NM_013542 6826116 -0.88333 0.000944 9030625A04Rik RIKEN cDNA 9030625A04 gene, mRNA (cDNA clone MGC BC116748 6828663 -0.69 0.006221 Capsl calcyphosine-like (Capsl), mRNA. NM_029341 6829277 -3.15 0.00053 Myo10 myosin X (Myo10), mRNA. NM_019472 6830481 -1.26333 0.007639 Nov nephroblastoma overexpressed gene (Nov), mRNA. NM_010930 6831162 -0.82 0.000716 Tg thyroglobulin (Tg), mRNA. NM_009375 6832146 -0.23333 0.004524 Csdc2 cold shock domain containing C2, RNA binding (Csdc2), mRNM_145473 6832394 -1.46333 0.004509 Gtse1 G two S phase expressed protein 1 (Gtse1), transcript varia NM_013882 6833311 1.13 0.005422 Nr4a1 nuclear receptor subfamily 4, group A, member 1 (Nr4a1), mNM_010444 6833980 -1.63 0.004687 Rai14 retinoic acid induced 14 (Rai14), transcript variant 2, mRNA NM_001166408 6835938 1.066667 0.00764 Fbxo32 F-box protein 32 (Fbxo32), mRNA. NM_026346 6836237 0.863333 0.009568 Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 ( NM_010026 6836854 1.346667 0.009891 Arhgap39 Rho GTPase activating protein 39 (Arhgap39), transcript varNM_001168288 6836959 -1.37 0.001668 Apol7c apolipoprotein L 7c (Apol7c), mRNA. NM_175391 6837144 0.823333 0.006474 Pdgfb platelet derived growth factor, B polypeptide (Pdgfb), mRNANM_011057 6837614 1.636667 0.002724 Cerk ceramide kinase (Cerk), mRNA. NM_145475 6838386 -0.90667 0.002868 Adcy6 adenylate cyclase 6 (Adcy6), mRNA. NM_007405 6838565 0.676667 0.001217 Pou6f1 POU domain, class 6, transcription factor 1 (Pou6f1), mRNANM_010127 6838730 -1.33333 0.001695 Aaas achalasia, adrenocortical insufficiency, alacrimia (Aaas), mRNM_153416 6838754 0.97 0.006227 Calcoco1 calcium binding and coiled coil domain 1 (Calcoco1), mRNANM_026192 6839919 1.22 0.002937 Klhl24 kelch-like 24 (Drosophila) (Klhl24), mRNA. NM_029436 6840637 -1.46667 0.008063 Itgb5 integrin beta 5 (Itgb5), transcript variant 1, mRNA. NM_001145884 6840737 0.183333 0.007273 Wdr5b WD repeat domain 5B (Wdr5b), mRNA. NM_027113 6841019 1.813333 0.005297 Zbtb20 zinc finger and BTB domain containing 20 (Zbtb20), transcri NM_019778 6841136 -1.29 0.009977 Cd200r1 CD200 receptor 1 (Cd200r1), mRNA. NM_021325 6841712 0.776667 0.009192 Abi3bp ABI gene family, member 3 (NESH) binding protein (Abi3bp NM_001014423 6841865 -0.98667 0.007424 Cldnd1 claudin domain containing 1 (Cldnd1), mRNA. NM_171826 6842009 -1.73333 0.00309 Pros1 protein S (alpha) (Pros1), mRNA. NM_011173 6843184 0.903333 0.000766 Ifngr2 interferon gamma receptor 2 (Ifngr2), mRNA. NM_008338 6843384 1.266667 0.004231 Ttc3 tetratricopeptide repeat domain 3 (Ttc3), mRNA. NM_009441 6844653 1.86 0.002205 Bcl6 B-cell leukemia/lymphoma 6 (Bcl6), mRNA. NM_009744 6845366 0.54 0.002463 Dirc2 disrupted in renal carcinoma 2 (human) (Dirc2), mRNA. NM_153550 6845444 0.97 0.006034 Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 NM_021301 6845911 0.663333 0.001673 Zdhhc23 zinc finger, DHHC domain containing 23 (Zdhhc23), mRNA. NM_001007460 6845933 1.183333 0.001132 Sidt1 SID1 transmembrane family, member 1 (Sidt1), transcript vaNM_001159419 6846010 1.356667 0.001887 Cd96 CD96 antigen (Cd96), mRNA. NM_032465 6846105 -1.33667 0.006566 Trat1 T cell receptor associated transmembrane adaptor 1 (Trat1)NM_198297 6847190 -1.39 0.003771 Samsn1 SAM domain, SH3 domain and nuclear localization signals, NM_023380 6847823 -2.56667 0.000893 Gcfc1 GC-rich sequence DNA-binding factor 1 (Gcfc1), mRNA. NM_026110 6847876 1.173333 0.00226 Tmem50b transmembrane protein 50B (Tmem50b), mRNA. NM_030018 6848479 0.18 0.001462 Zdhhc14 zinc finger, DHHC domain containing 14 (Zdhhc14), mRNA. NM_146073 6848553 1.686667 0.001074 Tagap T-cell activation Rho GTPase-activating protein (Tagap), mRNM_145968 6848579 1.153333 0.001158 Ccr6 chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 1NM_009835 6849307 -0.48333 0.004826 Nthl1 nth (endonuclease III)-like 1 (E.coli) (Nthl1), mRNA. NM_008743 6849595 -3.61 0.000174 Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a), transc NM_007669 6849626 -1.46 0.006623 Pim1 proviral integration site 1 (Pim1), mRNA. NM_008842 6849891 -0.73 0.009676 Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 (CypNM_001101588 6850138 -0.4 0.001058 H2-Q1 histocompatibility 2, Q region locus 1 (H2-Q1), mRNA. NM_010390 6850271 1.23 0.009068 Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 (Gabbr1), mNM_019439 6850695 0.913333 0.007301 Zfp318 zinc finger protein 318 (Zfp318), transcript variant 1, mRNA. NM_207671 6852181 0.79 0.005959 Ehd3 EH-domain containing 3 (Ehd3), mRNA. NM_020578 6852836 -4.57 1.69E-05 Epas1 endothelial PAS domain protein 1 (Epas1), mRNA. NM_010137 6852934 0.343333 0.002317 Ston1 stonin 1 (Ston1), mRNA. NM_029858 6854446 0.35 0.004799 Rhbdl1 rhomboid, veinlet-like 1 (Drosophila) (Rhbdl1), mRNA. NM_144816 6854907 -0.35 0.005422 Zfp870 zinc finger protein 870 (Zfp870), mRNA. NM_207245 6855478 0.47 0.000901 Slc25a27 solute carrier family 25, member 27 (Slc25a27), nuclear genNM_028711 6855981 -0.94667 0.001057 Satb1 special AT-rich sequence binding protein 1 (Satb1), transcripNM_009122 6856276 0.75 0.001258 Slc25a23 solute carrier family 25 (mitochondrial carrier; phosphate ca NM_025877 6857183 -1.38667 0.003237 Xdh xanthine dehydrogenase (Xdh), mRNA. NM_011723 6857799 1.493333 0.009211 Thada thyroid adenoma associated (Thada), mRNA. NM_183021 6859411 -1.35667 0.004231 Mapre2 microtubule-associated protein, RP/EB family, member 2 (MNM_153058 6860780 -0.64333 0.006656 Tnfaip8 tumor necrosis factor, alpha-induced protein 8 (Tnfaip8), tra NM_134131 6861751 2.806667 0.000561 D18Ertd653e DNA segment, Chr 18, ERATO Doi 653, expressed, mRNA BC096371 6863048 -1.51333 0.000672 Map3k8 mitogen-activated protein kinase kinase kinase 8 (Map3k8), NM_007746 6864565 -1.63 0.007021 Hspa9 heat shock protein 9 (Hspa9), nuclear gene encoding mitochNM_010481 6865551 0.506667 0.000525 Ppic peptidylprolyl isomerase C (Ppic), mRNA. NM_008908 6865643 -2.36667 0.00132 Zfp608 zinc finger protein 608 (Zfp608), mRNA. NM_175751 6866021 0.83 0.006772 Adrb2 adrenergic receptor, beta 2 (Adrb2), mRNA. NM_007420 6866852 0.406667 0.006719 Slc14a1 solute carrier family 14 (urea transporter), member 1 (Slc14 NM_001171010 6868055 0.536667 0.00838 A430093F15Rik RIKEN cDNA A430093F15 gene (A430093F15Rik), non-codNR_027805 6868110 0.37 0.006272 Ms4a4d membrane-spanning 4-domains, subfamily A, member 4D ( NM_025658 6869035 -1.18667 0.005122 Pdcd1lg2 programmed cell death 1 ligand 2 (Pdcd1lg2), mRNA. NM_021396 6869635 -1.70333 0.001739 Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 (Entpd1)NM_009848 6871062 0.293333 0.006994 Npas4 neuronal PAS domain protein 4 (Npas4), mRNA. NM_153553 6872739 -2.24667 0.002354 Lipo1 lipase, member O1 (Lipo1), mRNA. NM_001013770 6873167 -0.23333 0.00207 Morn4 MORN repeat containing 4 (Morn4), mRNA. NM_198108 6873246 -1.35667 0.006339 Erlin1 ER lipid raft associated 1 (Erlin1), transcript variant 1, mRNANM_145502 6873368 1.426667 0.004036 Kcnip2 Kv channel-interacting protein 2 (Kcnip2), transcript variant aNM_145703 6874683 -0.90667 0.001249 Nudt5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 NM_016918 6874947 -1.44333 4.08E-06 Itih5 inter-alpha (globulin) inhibitor H5 (Itih5), mRNA. NM_172471 6875038 -1.49 0.000835 Il2ra interleukin 2 receptor, alpha chain (Il2ra), mRNA. NM_008367 6875214 -2.36 8.18E-05 Plxdc2 plexin domain containing 2 (Plxdc2), mRNA. NM_026162 6875421 -0.31667 0.009128 Msrb2 methionine sulfoxide reductase B2 (Msrb2), mRNA. NM_029619 6875649 0.28 0.008735 Il1rn interleukin 1 receptor antagonist (Il1rn), transcript variant 1, NM_031167 6876238 0.563333 0.00061 Angptl2 angiopoietin-like 2 (Angptl2), mRNA. NM_011923 6876380 -1.23 0.006434 Gsn gelsolin (Gsn), mRNA. NM_146120 6876914 1.616667 0.008405 Acvr2a activin receptor IIA (Acvr2a), mRNA. NM_007396 6876944 1.053333 0.000739 Lypd6b LY6/PLAUR domain containing 6B (Lypd6b), mRNA. NM_027990 6877932 -0.28667 0.001269 Klhl23 kelch-like 23 (Drosophila) (Klhl23), mRNA. NM_177784 6878038 1.4 0.002057 Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 (Rapgef4)NM_019688 6878045 1.173333 1.24E-05 --- cdna:known chromosome:NCBIM37:2:71978785:72001443: --- 6878049 -0.53333 0.002665 B230120H23Rik RIKEN cDNA B230120H23 gene (B230120H23Rik), transcr NM_001164791 6878430 -0.58333 0.009071 Ube2e3 ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeasNM_009454 6880577 0.553333 0.001679 Ganc glucosidase, alpha; neutral C (Ganc), mRNA. NM_172672 6880718 0.61 1.17E-05 Sqrdl sulfide quinone reductase-like (yeast) (Sqrdl), nuclear gene NM_021507 6880776 2.05 0.001663 Sema6d sema domain, transmembrane domain (TM), and cytoplasmNM_199241 6881455 -0.99 0.001439 Plcb4 phospholipase C, beta 4 (Plcb4), mRNA. NM_013829 6883640 0.886667 0.005843 Spo11 sporulation protein, meiosis-specific, SPO11 homolog (S. ceNM_012046 6884155 -1.75 0.003091 Slco4a1 solute carrier organic anion transporter family, member 4a1 NM_148933 6884302 0.806667 0.006539 Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase doNM_153594 6884305 -1.16 0.002391 Polr3k polymerase (RNA) III (DNA directed) polypeptide K (Polr3k) NM_025901 6884642 -1.91333 0.005616 Gata3 GATA binding protein 3 (Gata3), mRNA. NM_008091 6885039 -1.33333 0.006218 Dnajc1 DnaJ (Hsp40) homolog, subfamily C, member 1 (Dnajc1), tr NM_007869 6885855 1.756667 0.004959 Fam78a family with sequence similarity 78, member A, mRNA (cDNABC137951 6885873 -0.15667 0.002562 Lcn2 lipocalin 2 (Lcn2), mRNA. NM_008491 6886356 -0.65667 0.006932 Zeb2 zinc finger E-box binding homeobox 2 (Zeb2), transcript variNM_015753 6886678 -0.89 0.006767 Rnd3 Rho family GTPase 3 (Rnd3), mRNA. NM_028810 6887661 -0.47333 0.009312 5830411J07Rik adult male thymus cDNA, RIKEN full-length enriched library AK017919 6888133 -0.91 0.000894 Pde1a phosphodiesterase 1A, calmodulin-dependent (Pde1a), tran NM_001159582 6888296 -2.26667 0.000616 Calcrl calcitonin receptor-like (Calcrl), mRNA. NM_018782 6888307 -0.38333 0.005793 Ctnnd1 catenin (cadherin associated protein), delta 1 (Ctnnd1), tran NM_007615 6888898 -0.99667 0.006064 Cd82 CD82 antigen (Cd82), transcript variant 1, mRNA. NM_007656 6889510 -1.52333 0.009108 2700007P21Rik RIKEN cDNA 2700007P21 gene (2700007P21Rik), transcripNM_001025102 6890448 -0.75667 0.006264 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransfNM_025961 6892032 1.49 0.000707 Acss1 acyl-CoA synthetase short-chain family member 1 (Acss1), nNM_080575 6892180 -0.97 0.005534 Bcl2l1 BCL2-like 1 (Bcl2l1), nuclear gene encoding mitochondrial pNM_009743 6892504 1.36 0.000773 Samhd1 SAM domain and HD domain, 1 (Samhd1), transcript varian NM_001139520 6892579 -1.91667 0.001949 Tgm2 transglutaminase 2, C polypeptide (Tgm2), mRNA. NM_009373 6895856 3.24 0.004326 Car2 carbonic anhydrase 2 (Car2), mRNA. NM_009801 6896353 1.313333 0.0096 Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 (TnfsNM_009425 6899359 -1.25333 0.003814 S100a13 S100 calcium binding protein A13 (S100a13), mRNA. NM_009113 6899572 1.09 0.000358 Rorc RAR-related orphan receptor gamma (Rorc), mRNA. NM_011281 6899683 1.863333 0.001191 Ctss cathepsin S (Ctss), mRNA. NM_021281 6899743 0.493333 0.006746 Sv2a synaptic vesicle glycoprotein 2 a (Sv2a), mRNA. NM_022030 6899750 -0.67667 0.004896 Hist2h3c1 histone cluster 2, H3c1 (Hist2h3c1), mRNA. NM_178216 6900095 -0.38 0.000269 Dennd2c DENN/MADD domain containing 2C (Dennd2c), mRNA. NM_177857 6900348 -1.97333 0.007418 Gstm5 glutathione S-transferase, mu 5 (Gstm5), mRNA. NM_010360 6900456 -0.93333 0.006891 Vav3 vav 3 oncogene (Vav3), transcript variant 1, mRNA. NM_020505 6902179 0.44 0.000741 Mcoln3 mucolipin 3 (Mcoln3), mRNA. NM_134160 6903557 -0.77 0.000423 Cpa3 carboxypeptidase A3, mast cell (Cpa3), mRNA. NM_007753 6904047 -1.44333 0.000786 Zmat3 zinc finger matrin type 3 (Zmat3), mRNA. NM_009517 6904262 -0.77333 0.005511 Dcun1d1 DCN1, defective in cullin neddylation 1, domain containing 1NM_033623 6905408 -3.38667 0.001272 P2ry14 purinergic receptor P2Y, G-protein coupled, 14 (P2ry14), tra NM_133200 6905818 2.74 0.000486 Ift80 intraflagellar transport 80 homolog (Chlamydomonas) (Ift80)NM_026641 6905821 1.893333 0.00636 Trim59 tripartite motif-containing 59 (Trim59), mRNA. NM_025863 6906441 -0.12 0.007277 Trim2 tripartite motif-containing 2 (Trim2), mRNA. NM_030706 6906652 -0.97 0.000287 Fcrls Fc receptor-like S, scavenger receptor (Fcrls), mRNA. NM_030707 6906762 -0.16 0.009732 Rab25 RAB25, member RAS oncogene family (Rab25), mRNA. NM_016899 6906903 -3.18333 0.00238 S100a1 S100 calcium binding protein A1 (S100a1), mRNA. NM_011309 6907204 -3.84667 0.000419 Ecm1 extracellular matrix protein 1 (Ecm1), mRNA. NM_007899 6907971 -0.9 0.000875 Cd53 CD53 antigen (Cd53), mRNA. NM_007651 6907972 -1.52 0.001066 Olfr266 olfactory receptor 266 (Olfr266), mRNA. NM_146489 6908048 -0.79667 0.007249 Csf1 colony stimulating factor 1 (macrophage) (Csf1), transcript vNM_007778 6908461 2.143333 0.000583 S1pr1 sphingosine-1-phosphate receptor 1 (S1pr1), mRNA. NM_007901 6909310 -1.10667 0.002413 Ccdc109b coiled-coil domain containing 109B (Ccdc109b), mRNA. NM_025779 6910668 1.826667 0.002677 St6galnac3 // St6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-NM_011372 // NM_011372 6911884 -0.73333 0.002662 Tmem64 transmembrane protein 64 (Tmem64), mRNA. NM_181401 6913042 -1.39667 0.004758 Glipr2 GLI pathogenesis-related 2 (Glipr2), mRNA. NM_027450 6913315 1.293333 0.007703 Nr4a3 nuclear receptor subfamily 4, group A, member 3 (Nr4a3), mNM_015743 6913560 0.783333 0.005758 Slc44a1 solute carrier family 44, member 1 (Slc44a1), transcript variaNM_133891 6915650 0.496667 0.004444 Inadl InaD-like (Drosophila) (Inadl), transcript variant 1, mRNA. NM_172696 6916190 -1.93333 0.005296 Orc1 origin recognition complex, subunit 1 (Orc1), transcript variaNM_011015 6917496 -1.84333 0.001651 Sesn2 sestrin 2 (Sesn2), mRNA. NM_144907 6917650 -0.27333 0.005403 Pafah2 platelet-activating factor acetylhydrolase 2 (Pafah2), mRNA.NM_133880 6917789 -0.80333 0.000479 Cnr2 cannabinoid receptor 2 (macrophage) (Cnr2), mRNA. NM_009924 6917809 1.92 0.000556 Id3 inhibitor of DNA binding 3 (Id3), mRNA. NM_008321 6917997 2.143333 0.000451 Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 (CNM_025451 6919003 0.606667 0.006929 Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 (Tnf NM_033042 6919208 -0.98333 0.004177 Sdf4 stromal cell derived factor 4 (Sdf4), mRNA. NM_011341 6919209 -2.30667 0.000359 Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 (TnfrsNM_011659 6919320 -2.72333 0.000531 Penk preproenkephalin (Penk), mRNA. NM_001002927 6919417 2.093333 5.62E-05 Tox thymocyte selection-associated high mobility group box (ToxNM_145711 6921012 0.8 0.003 Aqp3 aquaporin 3 (Aqp3), mRNA. NM_016689 6921154 2.01 0.000693 Cd72 CD72 antigen (Cd72), transcript variant 1, mRNA. NM_001110320 6921375 -1.16333 0.009051 Hemgn hemogen (Hemgn), mRNA. NM_053149 6921670 0.433333 0.007727 Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 (AbcNM_013454 6923059 -1.95667 0.001192 Plin2 perilipin 2 (Plin2), mRNA. NM_007408 6923760 0.456667 0.007887 Itgb3bp integrin beta 3 binding protein (beta3-endonexin) (Itgb3bp), NM_026348 6924017 -2.04333 0.001093 Wdr78 WD repeat domain 78 (Wdr78), mRNA. NM_146254 6924750 0.763333 0.006353 Faah fatty acid amide hydrolase (Faah), mRNA. NM_010173 6925587 -0.24 0.000262 Ccdc28b coiled coil domain containing 28B (Ccdc28b), mRNA. NM_025455 6926029 1.343333 0.007376 Ldlrap1 low density lipoprotein receptor adaptor protein 1 (Ldlrap1), NM_145554 6926655 -3.33333 0.000419 Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 (TnfrsNM_009401 6927231 1.406667 0.000908 Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (her NM_178931 6928457 -1.96333 0.001231 Cdk6 cyclin-dependent kinase 6 (Cdk6), mRNA. NM_009873 6928939 -2.47667 0.000186 Hgf hepatocyte growth factor (Hgf), mRNA. NM_010427 6929647 0.593333 0.00694 Mapre3 microtubule-associated protein, RP/EB family, member 3 (MNM_133350 6929719 -2.34333 0.005363 Fosl2 fos-like antigen 2 (Fosl2), mRNA. NM_008037 6929720 -0.17333 0.001193 Plb1 phospholipase B1 (Plb1), transcript variant 1, mRNA. NM_001081407 6931529 0.996667 0.002119 Atp10d ATPase, class V, type 10D (Atp10d), non-coding RNA. NR_003966 6931759 4.21 3.26E-05 Kit kit oncogene (Kit), transcript variant 1, mRNA. NM_001122733 6933014 -1.82667 0.003902 Ptpn13 protein tyrosine phosphatase, non-receptor type 13 (Ptpn13 NM_011204 6933283 -1.09 0.002023 1700013N18Rik RIKEN cDNA 1700013N18 gene (1700013N18Rik), non-codNR_003639 6933441 1.403333 0.005979 --- cdna:known chromosome:NCBIM37:5:110950181:11095499--- 6933600 0.386667 0.00051 Myo1h myosin 1H (Myo1h), mRNA. NM_001164573 6934652 -0.97667 0.005758 Tpst1 protein-tyrosine sulfotransferase 1 (Tpst1), transcript variantNM_001130476 6935408 1.833333 0.001372 Cyth3 cytohesin 3 (Cyth3), transcript variant 1, mRNA. NM_011182 6939358 0.66 0.004195 Igfbp7 insulin-like growth factor binding protein 7 (Igfbp7), transcripNM_001159518 6940146 -0.34333 0.006212 Cnot6l CCR4-NOT transcription complex, subunit 6-like (Cnot6l), tr NM_178854 6940595 -0.67333 0.007497 Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 (Hsd17b11), mRNM_053262 6942376 3.203333 0.000339 Ncf1 neutrophil cytosolic factor 1 (Ncf1), mRNA. NM_010876 6942377 0.983333 0.005908 Gtf2i general transcription factor II I (Gtf2i), transcript variant 1, mNM_001080746 6942441 -2.19333 0.002025 Hip1 huntingtin interacting protein 1 (Hip1), mRNA. NM_146001 6942685 -0.28 0.005318 Micall2 MICAL-like 2 (Micall2), mRNA. NM_174850 6943387 0.66 0.002862 N4bp2l1 NEDD4 binding protein 2-like 1 (N4bp2l1), mRNA. NM_133898 6944581 0.21 0.001448 Wnt16 wingless-related MMTV integration site 16 (Wnt16), mRNA. NM_053116 6945034 -0.64 0.006989 Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 (Ahcyl2), transcripNM_021414 6945275 -0.97333 0.002784 Exoc4 exocyst complex component 4 (Exoc4), mRNA. NM_009148 6945611 -1.58667 0.002185 Rab19 RAB19, member RAS oncogene family (Rab19), mRNA. NM_011226 6945775 -1.02333 0.007184 Gstk1 glutathione S-transferase kappa 1 (Gstk1), nuclear gene en NM_029555 6946028 0.896667 0.007443 Gimap4 GTPase, IMAP family member 4 (Gimap4), transcript varianNM_174990 6946313 -0.53 0.002233 Creb5 cAMP responsive element binding protein 5 (Creb5), mRNA NM_172728 6946370 1.06 0.001564 2410066E13Rik RIKEN cDNA 2410066E13 gene, mRNA (cDNA clone MGC BC042507 6946920 2.47 0.002414 Cd8a CD8 antigen, alpha chain (Cd8a), transcript variant 1, mRNANM_001081110 6947763 -0.18 0.00519 Gata2 GATA binding protein 2 (Gata2), mRNA. NM_008090 6947814 -1.36333 0.00852 Mgll monoglyceride lipase (Mgll), transcript variant 1, mRNA. NM_001166251 6948906 -1.98 0.000252 Itpr1 inositol 1,4,5-triphosphate receptor 1 (Itpr1), mRNA. NM_010585 6949202 -2.35 0.001627 Pparg peroxisome proliferator activated receptor gamma (Pparg), tNM_001127330 6950266 0.673333 0.001547 Tas2r129 taste receptor, type 2, member 129 (Tas2r129), mRNA. NM_207029 6950394 -0.22667 0.005785 Gprc5a G protein-coupled receptor, family C, group 5, member A (GNM_181444 6950504 0.226667 0.007637 BC049715 cDNA sequence BC049715 (BC049715), mRNA. NM_178776 6951525 -2.37 0.005147 Asns asparagine synthetase (Asns), mRNA. NM_012055 6952097 1.076667 0.007134 Fam3c family with sequence similarity 3, member C (Fam3c), mRN NM_138587 6952936 -1.27 0.002785 Slc37a3 solute carrier family 37 (glycerol-3-phosphate transporter), mNM_028123 6953331 -1.19667 0.001185 Ezh2 enhancer of zeste homolog 2 (Drosophila) (Ezh2), transcriptNM_007971 6953523 -0.33667 0.00051 4921507P07Rik RIKEN cDNA 4921507P07 gene, mRNA (cDNA clone MGC BC055110 6953800 0.66 0.000712 Nod1 nucleotide-binding oligomerization domain containing 1 (NodNM_172729 6954269 2.306667 0.002562 Hpgds hematopoietic prostaglandin D synthase (Hpgds), mRNA. NM_019455 6954425 -0.47667 0.00582 Tacstd2 tumor-associated calcium signal transducer 2 (Tacstd2), mRNM_020047 6954584 -0.80333 0.007956 Mrpl35 mitochondrial ribosomal protein L35 (Mrpl35), nuclear gene NM_025430 6954617 -0.33667 0.009776 Vamp5 vesicle-associated membrane protein 5 (Vamp5), transcript NM_016872 6954626 -0.96 0.009115 Mat2a methionine adenosyltransferase II, alpha (Mat2a), mRNA. NM_145569 6955431 -1.82333 0.000246 Plxna1 plexin A1 (Plxna1), mRNA. NM_008881 6955698 2.256667 0.000109 Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 (Lri NM_008377 6955879 1.233333 0.002424 Foxp1 forkhead box P1 (Foxp1), transcript variant 1, mRNA. NM_053202 6956902 -1.06667 0.003765 Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunNM_001159533 6957185 0.886667 0.00331 Cd9 CD9 antigen (Cd9), mRNA. NM_007657 6957472 -0.55 0.007551 Tas2r104 taste receptor, type 2, member 104 (Tas2r104), mRNA. NM_207011 6957758 0.723333 0.008209 Art4 ADP-ribosyltransferase 4 (Art4), mRNA. NM_026639 6957789 -1.53333 0.007746 Eps8 epidermal growth factor receptor pathway substrate 8 (Eps8NM_007945 6958059 -0.66333 0.006954 Ldhb lactate dehydrogenase B (Ldhb), mRNA. NM_008492 6959093 -0.47333 0.006599 Zfp112 zinc finger protein 112 (Zfp112), mRNA. NM_021307 6960404 1.293333 0.001638 Dbp D site albumin promoter binding protein (Dbp), mRNA. NM_016974 6961279 1.253333 0.003497 Igf1r insulin-like growth factor I receptor (Igf1r), mRNA. NM_010513 6961283 0.756667 0.002249 D930030O05Rik 15 days embryo head cDNA, RIKEN full-length enriched libr AK086466 6961895 -0.99 0.000204 Aen apoptosis enhancing nuclease (Aen), transcript variant 1, m NM_026531 6962094 -2.06 0.002627 Tm6sf1 transmembrane 6 superfamily member 1 (Tm6sf1), mRNA. NM_145375 6962933 -0.19 0.006991 Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) (Ucp3), nNM_009464 6963003 -0.93333 0.009478 Stard10 START domain containing 10 (Stard10), mRNA. NM_019990 6963006 1.41 0.003822 Pde2a phosphodiesterase 2A, cGMP-stimulated (Pde2a), transcrip NM_001143848 6963017 -0.27667 0.008296 3200002M19Rik RIKEN cDNA 3200002M19 gene, mRNA (cDNA clone MGCBC080730 6963364 -1.00333 0.004827 Rpl27a ribosomal protein L27A (Rpl27a), mRNA. NM_011975 6963901 -1.10667 0.00576 Lyrm1 LYR motif containing 1 (Lyrm1), mRNA. NM_029610 6964160 -1.37333 0.001265 Il4ra interleukin 4 receptor, alpha (Il4ra), mRNA. NM_001008700 6964246 1.2 0.004129 Ypel3 yippee-like 3 (Drosophila) (Ypel3), mRNA. NM_026875 6964247 0.966667 0.006015 Tbx6 T-box 6 (Tbx6), mRNA. NM_011538 6964380 0.186667 0.008636 Itgam integrin alpha M (Itgam), transcript variant 1, mRNA. NM_001082960 6964522 1.113333 0.005873 Plekha1 pleckstrin homology domain containing, family A (phosphoinNM_133942 6965316 -1.68667 0.004463 Cd81 CD81 antigen (Cd81), mRNA. NM_133655 6966189 -0.57 0.005735 Spred3 sprouty-related, EVH1 domain containing 3 (Spred3), mRNANM_182927 6966249 0.313333 0.005861 Zfp14 zinc finger protein 14 (Zfp14), transcript variant 1, mRNA. NM_011748 6966903 -1.72 0.002576 Atf5 activating transcription factor 5 (Atf5), transcript variant 1, m NM_030693 6966985 -1.08333 0.001019 Bax BCL2-associated X protein (Bax), mRNA. NM_007527 6968643 -0.64 0.001641 Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 (Ntrk3), transcNM_008746 6968762 0.823333 0.008022 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nNM_173011 6968828 -0.57 0.009336 Cpeb1 cytoplasmic polyadenylation element binding protein 1 (Cpe NM_007755 6969007 0.59 0.003678 Il16 interleukin 16 (Il16), mRNA. NM_010551 6969429 -1.97667 0.000305 4632434I11Rik RIKEN cDNA 4632434I11 gene (4632434I11Rik), mRNA. NM_001080995 6970393 -1.10667 0.002894 Dennd5a DENN/MADD domain containing 5A (Dennd5a), mRNA. NM_021494 6970916 -1.68 0.002126 Dcun1d3 DCN1, defective in cullin neddylation 1, domain containing 3NM_173408 6971437 1.28 0.00467 Rgs10 regulator of G-protein signalling 10 (Rgs10), mRNA. NM_026418 6971678 -1.03333 0.002473 Oat ornithine aminotransferase (Oat), nuclear gene encoding mi NM_016978 6971688 1.04 0.008352 Fam53b family with sequence similarity 53, member B (Fam53b), mRNM_175268 6972126 -1.88 0.000159 Olfr60 olfactory receptor 60 (Olfr60), mRNA. NM_146955 6972168 -3.65 0.000697 Ifitm3 interferon induced transmembrane protein 3 (Ifitm3), mRNA NM_025378 6972205 -0.96 0.005377 Lrdd leucine-rich and death domain containing (Lrdd), mRNA. NM_022654 6972411 1.01 0.003526 Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 (Tnf NM_175649 6973414 -0.83333 0.002272 Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independe NM_001004762 6975052 0.49 0.002137 Rnf122 ring finger protein 122 (Rnf122), mRNA. NM_175136 6975224 -2.22 0.000522 Tex15 testis expressed gene 15 (Tex15), mRNA. NM_031374 6976959 0.346667 0.001753 Pbx4 pre-B-cell leukemia homeobox 4 (Pbx4), mRNA. NM_001024954 6977042 -2.31 0.002226 Il12rb1 interleukin 12 receptor, beta 1 (Il12rb1), mRNA. NM_008353 6978156 -0.53 0.00271 Rbl2 retinoblastoma-like 2 (Rbl2), mRNA. NM_011250 6978319 -0.41333 0.003025 Cpne2 copine II (Cpne2), mRNA. NM_153507 6979319 -0.24333 0.003786 Clec3a C-type lectin domain family 3, member a (Clec3a), mRNA. NM_001007223 6980032 -1.62333 0.003641 Itgb1 integrin beta 1 (fibronectin receptor beta) (Itgb1), mRNA. NM_010578 6980606 0.686667 0.004487 2610019F03Rik RIKEN cDNA 2610019F03 gene (2610019F03Rik), mRNA. NM_173744 6980694 -0.11333 0.001457 BB014433 expressed sequence BB014433, mRNA (cDNA clone MGC:BC139040 6981870 0.45 0.009465 Mtmr7 myotubularin related protein 7 (Mtmr7), mRNA. NM_001040699 6983351 -0.24667 0.009844 Large like-glycosyltransferase (Large), mRNA. NM_010687 6983584 -0.46333 0.004816 Lsm6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevNM_001191004 6984452 0.973333 0.000367 9330175E14Rik RIKEN cDNA 9330175E14 gene (9330175E14Rik), non-codNR_015514 6984965 0.68 0.004246 Lrrc29 leucine rich repeat containing 29 (Lrrc29), mRNA. NM_177449 6985361 -1.72667 0.003346 Mlkl mixed lineage kinase domain-like (Mlkl), mRNA. NM_029005 6985900 -2.1 0.004255 Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ syNM_011404 6986649 -2.02 0.002306 Casp4 caspase 4, apoptosis-related cysteine peptidase (Casp4), mNM_007609 6987065 1.083333 0.001183 Sesn3 sestrin 3 (Sesn3), mRNA. NM_030261 6987638 -1.39 0.001437 Vps26b vacuolar protein sorting 26 homolog B (yeast) (Vps26b), mRNM_178027 6988958 1.51 0.00349 Usp28 ubiquitin specific peptidase 28 (Usp28), mRNA. NM_175482 6989440 -4.32333 4.37E-05 Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 (CypNM_019779 6989483 -1.22 6.33E-05 Nptn neuroplastin (Nptn), mRNA. NM_009145 6990167 1.42 0.009484 Rora RAR-related orphan receptor alpha (Rora), mRNA. NM_013646 6990842 -0.79333 0.00032 Mei4 meiosis-specific, MEI4 homolog (S. cerevisiae) (Mei4), mRNNM_175213 6991192 3.933333 0.00026 Nt5e 5' nucleotidase, ecto (Nt5e), mRNA. NM_011851 6991368 1.693333 0.003633 Plscr4 phospholipid scramblase 4 (Plscr4), mRNA. NM_178711 6994589 -1.45667 0.004152 Fam118b family with sequence similarity 118, member B, mRNA (cDNBC051180 6994883 0.526667 0.009436 Crtam cytotoxic and regulatory T cell molecule (Crtam), mRNA. NM_019465 6995793 0.283333 0.009058 AY074887 cDNA sequence AY074887 (AY074887), mRNA. NM_145229 6996678 -2.49667 0.000678 Aqp9 aquaporin 9 (Aqp9), mRNA. NM_022026 6998614 -1.48333 0.00206 Hemk1 HemK methyltransferase family member 1 (Hemk1), mRNA NM_133984 6999129 -2.02 0.000511 ------6999130 -2.70667 0.007888 Ccr4 chemokine (C-C motif) receptor 4 (Ccr4), mRNA. NM_009916 7009771 1.606667 0.001853 Foxp3 forkhead box P3 (Foxp3), mRNA. NM_054039 7013900 -0.32667 0.000891 Armcx1 armadillo repeat containing, X-linked 1 (Armcx1), transcript vNM_001166377 7013954 -0.71 0.001838 Armcx5 armadillo repeat containing, X-linked 5 (Armcx5), mRNA. NM_001009575 7015058 -0.56 0.009761 Gemin8 gem (nuclear organelle) associated protein 8 (Gemin8), mR NM_146238 7015061 -2.6 0.000178 Gpm6b glycoprotein m6b (Gpm6b), transcript variant 2, mRNA. NM_001177956 7018220 -1.24333 0.006316 Pola1 polymerase (DNA directed), alpha 1 (Pola1), mRNA. NM_008892 7018290 0.52 0.008416 Fam123b family with sequence similarity 123, member B (Fam123b), NM_175179 7018804 -2.61 0.006137 Cysltr1 cysteinyl leukotriene receptor 1 (Cysltr1), mRNA. NM_021476 7019532 -0.66333 0.001637 Armcx6 armadillo repeat containing, X-linked 6 (Armcx6), mRNA. NM_001007578 7020371 -2.01333 0.000747 Prdx4 peroxiredoxin 4 (Prdx4), mRNA. NM_016764 7020802 2.173333 0.000245 Tlr7 toll-like receptor 7 (Tlr7), mRNA. NM_133211 Regateiro et al Supplementary Table III Probe Set IDlog ratio CD2+/- p-value Gene Symbol mRNA - Description mRNA Accession 7009771 3.94849 1.57E-06 Foxp3 forkhead box P3 (Foxp3), mRNA. NM_054039 6754681 2.757752 4.19E-05 Sell selectin, lymphocyte (Sell), transcript variant 1, mRNNM_011346 6776185 2.644686 1.78E-06 Socs2 suppressor of cytokine signaling 2 (Socs2), transcripNM_007706 6805380 2.520148 0.005095 Hist1h2bb histone cluster 1, H2bb (Hist1h2bb), mRNA. NM_175664 6805270 2.391747 0.00524 Hist1h2bk histone cluster 1, H2bk (Hist1h2bk), mRNA. NM_175665 6800468 2.261992 9.74E-06 Stxbp6 syntaxin binding protein 6 (amisyn) (Stxbp6), mRNANM_144552 6999130 2.126228 0.000178 Ccr4 chemokine (C-C motif) receptor 4 (Ccr4), mRNA. NM_009916 6849626 2.049882 0.001013 Pim1 proviral integration site 1 (Pim1), mRNA. NM_008842 6751535 1.854091 0.000522 Ramp1 receptor (calcitonin) activity modifying protein 1 (RamNM_016894 6938678 1.794879 0.000247 Tlr1 toll-like receptor 1 (Tlr1), mRNA. NM_030682 6929407 1.692357 5.5E-05 Actr3b ARP3 actin-related protein 3 homolog B (yeast) (ActNM_001004365 6965316 1.621233 0.001678 Cd81 CD81 antigen (Cd81), mRNA. NM_133655 6971848 1.609266 0.004819 Mki67 antigen identified by monoclonal antibody Ki 67 (Mk NM_001081117 6763706 1.605888 0.006752 Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide (ANM_009721 6980016 1.560363 0.00523 Nrp1 neuropilin 1 (Nrp1), mRNA. NM_008737 6969669 1.52123 1.45E-06 A630091E08Rik Putative uncharacterized protein gene:ENSMUSG00ENSMUST00000069035 6904300 1.508883 0.000331 Ccna2 cyclin A2 (Ccna2), mRNA. NM_009828 6913561 1.502389 0.000838 Fsd1l fibronectin type III and SPRY domain containing 1-li NM_176966 6989974 1.466947 0.001554 2810417H13Rik RIKEN cDNA 2810417H13 gene (2810417H13Rik), NM_026515 7020371 1.466553 0.005884 Prdx4 peroxiredoxin 4 (Prdx4), mRNA. NM_016764 6875038 1.449298 0.000125 Il2ra interleukin 2 receptor, alpha chain (Il2ra), mRNA. NM_008367 6840849 1.441723 0.002669 Cd80 CD80 antigen (Cd80), mRNA. NM_009855 6975335 1.423442 0.00518 Dusp4 dual specificity phosphatase 4 (Dusp4), mRNA. NM_176933 6805386 1.409981 0.000312 Hist1h1a histone cluster 1, H1a (Hist1h1a), mRNA. NM_030609 6811530 1.379471 0.006832 Hist1h1b histone cluster 1, H1b (Hist1h1b), mRNA. NM_020034 6791298 1.372706 0.000688 Top2a topoisomerase (DNA) II alpha (Top2a), mRNA. NM_011623 6946993 1.350968 0.007551 Capg capping protein (actin filament), gelsolin-like (Capg) NM_007599 7015521 1.315718 0.000677 Cybb cytochrome b-245, beta polypeptide (Cybb), mRNA. NM_007807 6869503 1.275529 0.001531 Kif11 kinesin family member 11 (Kif11), mRNA. NM_010615 6880529 1.265558 0.00218 Nusap1 nucleolar and spindle associated protein 1 (Nusap1)NM_133851 6863048 1.265299 0.003359 Map3k8 mitogen-activated protein kinase kinase kinase 8 (MNM_007746 6992209 1.229366 0.001321 Cish cytokine inducible SH2-containing protein (Cish), mRNM_009895 6919209 1.201206 0.001986 Tnfrsf4 tumor necrosis factor receptor superfamily, memberNM_011659 6999129 1.198989 0.004681 ------6955219 1.178221 0.000676 Mxd1 MAX dimerization protein 1 (Mxd1), mRNA. NM_010751 6919212 1.17182 0.005667 Tnfrsf18 tumor necrosis factor receptor superfamily, memberNM_009400 6831798 1.150015 0.009198 Ncf4 neutrophil cytosolic factor 4 (Ncf4), mRNA. NM_008677 6996186 1.133177 0.002167 Kif23 kinesin family member 23 (Kif23), mRNA. NM_024245 6875132 1.12971 0.00049 Vim vimentin (Vim), mRNA. NM_011701 6963006 1.128583 0.006764 Pde2a phosphodiesterase 2A, cGMP-stimulated (Pde2a), t NM_001143848 6963744 1.127497 0.004226 Nucb2 nucleobindin 2 (Nucb2), transcript variant 1, mRNA. NM_001130479 6993481 1.118877 0.001385 Folr4 folate receptor 4 (delta) (Folr4), transcript variant 1, NM_022888 6754027 1.104407 0.007426 Fam129a family with sequence similarity 129, member A (FamNM_022018 6958974 1.104216 0.000453 Pglyrp1 peptidoglycan recognition protein 1 (Pglyrp1), mRNANM_009402 6784062 1.103651 1.15E-05 Igfbp4 insulin-like growth factor binding protein 4 (Igfbp4), mNM_010517 6996646 1.08477 0.000736 Ccnb2 cyclin B2 (Ccnb2), mRNA. NM_007630 6901592 1.084326 0.006792 Cenpe centromere protein E (Cenpe), mRNA. NM_173762 6987384 1.083608 0.00184 AB124611 cDNA sequence AB124611 (AB124611), mRNA. NM_206536 6767537 1.079335 0.000651 Cd24a CD24a antigen (Cd24a), mRNA. NM_009846 6840579 1.071065 0.009305 Tfrc transferrin receptor (Tfrc), mRNA. NM_011638 6993098 1.058526 0.003004 Kif15 kinesin family member 15 (Kif15), mRNA. NM_010620 6963548 1.056196 5.89E-05 Tead1 TEA domain family member 1 (Tead1), transcript vaNM_001166584 6961987 1.05485 0.002713 Prc1 protein regulator of cytokinesis 1 (Prc1), mRNA. NM_145150 6773633 1.004301 0.004558 Aim1 absent in melanoma 1 (Aim1), mRNA. NM_172393 6790317 1.004152 0.004354 Dusp14 dual specificity phosphatase 14 (Dusp14), mRNA. NM_019819 6851232 0.990836 0.003693 Uhrf1 ubiquitin-like, containing PHD and RING finger dom NM_010931 6907204 0.975367 0.002125 Ecm1 extracellular matrix protein 1 (Ecm1), mRNA. NM_007899 6882333 0.97169 0.00149 Tpx2 TPX2, microtubule-associated protein homolog (XenNM_001141977 6924834 0.956246 0.00181 Kif2c kinesin family member 2C (Kif2c), mRNA. NM_134471 6982550 0.956089 0.005707 Neil3 nei like 3 (E. coli) (Neil3), mRNA. NM_146208 6801335 0.920881 0.003839 C79407 expressed sequence C79407 (C79407), mRNA. NM_172578 7012842 0.917305 0.007462 Kif4 kinesin family member 4 (Kif4), mRNA. NM_008446 6996254 0.913784 0.006097 Smad3 MAD homolog 3 (Drosophila) (Smad3), mRNA. NM_016769 6911884 0.898401 0.005965 Tmem64 transmembrane protein 64 (Tmem64), mRNA. NM_181401 6756394 0.890823 0.002966 Nek2 NIMA (never in mitosis gene a)-related expressed k NM_010892 6856096 0.886107 0.000665 Sgol1 shugoshin-like 1 (S. pombe) (Sgol1), mRNA. NM_028232 6884642 0.875544 0.002481 Gata3 GATA binding protein 3 (Gata3), mRNA. NM_008091 6753592 0.87269 0.008528 Aspm asp (abnormal spindle)-like, microcephaly associateNM_009791 6931217 0.870547 0.005579 Klf3 Kruppel-like factor 3 (basic) (Klf3), mRNA. NM_008453 6880492 0.864401 0.008328 Casc5 cancer susceptibility candidate 5 (Casc5), mRNA. NM_029617 6916483 0.864162 0.009783 Stil Scl/Tal1 interrupting locus (Stil), mRNA. NM_009185 6892831 0.844019 0.005036 Serinc3 serine incorporator 3 (Serinc3), mRNA. NM_012032 6990263 0.825312 0.005825 Myo1e myosin IE (Myo1e), mRNA. NM_181072 6989438 0.817489 0.005174 Sema7a sema domain, immunoglobulin domain (Ig), and GPNM_011352 6775472 0.808697 0.007633 Gna15 guanine nucleotide binding protein, alpha 15 (Gna15NM_010304 6887520 0.807733 0.004207 Spc25 SPC25, NDC80 kinetochore complex component, h NM_025565 6787469 0.801344 0.008038 Hmmr hyaluronan mediated motility receptor (RHAMM) (HmNM_013552 6784236 0.795498 0.001326 Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 NM_016920 6870971 0.786258 0.003891 BC021614 cDNA sequence BC021614, mRNA (cDNA clone M BC034269 6830770 0.76722 0.005101 Trib1 tribbles homolog 1 (Drosophila) (Trib1), mRNA. NM_144549 6913042 0.766363 0.007368 Glipr2 GLI pathogenesis-related 2 (Glipr2), mRNA. NM_027450 7015399 0.756898 0.001037 Ccdc22 coiled-coil domain containing 22 (Ccdc22), mRNA. NM_138603 6781970 0.749894 0.001554 Aurkb aurora kinase B (Aurkb), mRNA. NM_011496 6782610 0.747784 0.007372 Myo18a myosin XVIIIA (Myo18a), mRNA. NM_011586 6967211 0.724515 0.002758 E2f8 E2F transcription factor 8 (E2f8), mRNA. NM_001013368 6969693 0.717672 0.000527 Dgat2 diacylglycerol O-acyltransferase 2 (Dgat2), mRNA. NM_026384 6878712 0.703965 0.00716 Slc43a1 solute carrier family 43, member 1 (Slc43a1), transcNM_001081349 6911337 0.702129 0.003145 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homoNM_001111096 6890658 0.696851 0.002079 Ncaph non-SMC condensin I complex, subunit H (Ncaph), NM_144818 6852934 0.687251 0.005708 Ston1 stonin 1 (Ston1), mRNA. NM_029858 6906749 0.686149 0.002183 Sema4a sema domain, immunoglobulin domain (Ig), transmeNM_013658 6748837 0.670441 0.000197 Npas2 neuronal PAS domain protein 2 (Npas2), mRNA. NM_008719 6998614 0.658952 0.007381 Hemk1 HemK methyltransferase family member 1 (Hemk1) NM_133984 6880468 0.645985 0.006592 D2Ertd750e DNA segment, Chr 2, ERATO Doi 750, expressed ( NM_026412 6760385 0.642947 0.009695 Pde6d phosphodiesterase 6D, cGMP-specific, rod, delta (PNM_008801 6933697 0.636967 0.006299 Cit citron (Cit), mRNA. NM_007708 6867830 0.635396 0.004075 Cdca5 cell division cycle associated 5 (Cdca5), mRNA. NM_026410 6892905 0.630673 0.006611 Sdc4 syndecan 4 (Sdc4), mRNA. NM_011521 6924465 0.630352 0.006561 --- cdna:known chromosome:NCBIM37:4:109324134:10ENSMUST00000156790 6913080 0.629827 0.003282 Melk maternal embryonic leucine zipper kinase (Melk), m NM_010790 6766301 0.626859 0.003327 Perp PERP, TP53 apoptosis effector (Perp), mRNA. NM_022032 6919012 0.6164 0.009526 Acot7 acyl-CoA thioesterase 7 (Acot7), transcript variant 1 NM_001146057 6983073 0.601952 0.005477 Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferasNM_172753 6825436 0.59302 0.009488 Esco2 establishment of cohesion 1 homolog 2 (S. cerevisiaNM_028039 6939338 0.568132 0.000878 Hopx HOP homeobox (Hopx), transcript variant 1, mRNA NM_175606 6875746 0.565201 0.001404 Lcn10 lipocalin 10 (Lcn10), mRNA. NM_178036 6830481 0.563012 0.006091 Nov nephroblastoma overexpressed gene (Nov), mRNA NM_010930 6938631 0.556934 0.008203 Rell1 RELT-like 1 (Rell1), mRNA. NM_145923 6979421 0.55183 0.000932 Cenpn centromere protein N (Cenpn), mRNA. NM_028131 6937466 0.544577 0.003482 Sorcs2 sortilin-related VPS10 domain containing receptor 2 NM_030889 6794331 0.51622 0.006189 Atxn7l1 ataxin 7-like 1 (Atxn7l1), transcript variant 1, mRNA NM_001033436 6961977 0.514676 0.006182 Sema4b sema domain, immunoglobulin domain (Ig), transmeNM_013659 6996267 0.505067 0.007379 Zwilch Zwilch, kinetochore associated, homolog (Drosophil NM_026507 6844598 0.501618 0.006249 Rfc4 replication factor C (activator 1) 4 (Rfc4), mRNA. NM_145480 6899372 0.494623 0.000324 S100a4 S100 calcium binding protein A4 (S100a4), mRNA. NM_011311 6963456 0.444879 0.003372 Ampd3 adenosine monophosphate deaminase 3 (Ampd3), NM_009667 6791504 0.428519 0.008304 Brca1 breast cancer 1 (Brca1), mRNA. NM_009764 7015432 0.428295 0.006322 Gata1 GATA binding protein 1 (Gata1), mRNA. NM_008089 6847748 0.42075 0.004693 Tiam1 T-cell lymphoma invasion and metastasis 1 (Tiam1)NM_009384 6805404 0.410444 0.0012 Hist1h2aa histone cluster 1, H2aa (Hist1h2aa), mRNA. NM_175658 6978332 0.405508 0.005868 Ccl22 chemokine (C-C motif) ligand 22 (Ccl22), mRNA. NM_009137 6946511 0.400846 0.002643 Lancl2 LanC (bacterial lantibiotic synthetase component C) NM_133737 6937434 0.388189 0.005775 Acox3 acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNM_030721 6957252 0.383222 0.002583 Rad51ap1 RAD51 associated protein 1 (Rad51ap1), mRNA. NM_009013 6962873 0.371419 0.001823 Mtap6 microtubule-associated protein 6 (Mtap6), transcript NM_001048167 6962941 0.36881 0.007141 Chchd8 coiled-coil-helix-coiled-coil-helix domain containing 8NM_183270 6844359 0.359975 0.002535 Cdc45 cell division cycle 45 homolog (S. cerevisiae) (Cdc4 NM_009862 6969809 0.358251 0.00474 Dnajb13 DnaJ (Hsp40) related, subfamily B, member 13 (Dn NM_153527 6911719 0.357133 0.004922 Rad54b RAD54 homolog B (S. cerevisiae) (Rad54b), mRNANM_001039556 6768324 0.353498 0.009127 Dna2 DNA replication helicase 2 homolog (yeast) (Dna2), NM_177372 6901634 0.32612 0.003627 Slc39a8 solute carrier family 39 (metal ion transporter), memNM_001135150 6810299 0.324583 0.004199 Ppap2a phosphatidic acid phosphatase type 2A (Ppap2a), trNM_008903 6913133 0.311925 0.003835 1700055D18Rik Putative uncharacterized protein gene:ENSMUSG00ENSMUST00000095105 7015375 0.310064 0.007759 Clcn5 chloride channel 5 (Clcn5), mRNA. NM_016691 6838717 0.309675 0.00996 Rarg retinoic acid receptor, gamma (Rarg), transcript vari NM_011244 6959124 0.309394 0.003941 Plaur plasminogen activator, urokinase receptor (Plaur), mNM_011113 6942455 0.286903 0.005265 Rhbdd2 rhomboid domain containing 2 (Rhbdd2), mRNA. NM_146002 6854907 0.282804 0.007765 Zfp870 zinc finger protein 870 (Zfp870), mRNA. NM_207245 6913194 0.282614 0.008603 Tdrd7 tudor domain containing 7 (Tdrd7), mRNA. NM_146142 6951401 0.277755 0.004744 Pon3 paraoxonase 3 (Pon3), mRNA. NM_173006 7013153 0.273633 0.004668 Cypt2-ps cysteine-rich perinuclear theca 2, pseudogene (Cyp NM_173436 6964517 0.271584 0.004964 Tacc2 transforming, acidic coiled-coil containing protein 2 (NM_001004468 6761998 0.270892 0.0064 Zranb3 zinc finger, RAN-binding domain containing 3 (ZranbNM_027678 6885969 0.268685 0.009639 Pbx3 pre B-cell leukemia transcription factor 3 (Pbx3), mRNM_016768 6812770 0.263776 0.009922 Tbc1d7 TBC1 domain family, member 7 (Tbc1d7), mRNA. NM_025935 6770661 0.218317 0.003089 Csrp2 cysteine and glycine-rich protein 2 (Csrp2), mRNA. NM_007792 6993067 0.201382 0.002055 Abhd5 abhydrolase domain containing 5 (Abhd5), mRNA. NM_026179 6882774 0.200287 0.005533 Fam83d family with sequence similarity 83, member D, mRNBC068129 6985991 0.195216 0.008983 Fanca Fanconi anemia, complementation group A (Fanca) NM_016925 6881092 0.172733 0.003526 Fbln7 fibulin 7 (Fbln7), mRNA. NM_024237 6925559 0.125721 0.006796 Zbtb8a zinc finger and BTB domain containing 8a (Zbtb8a), NM_028603 6785644 0.10337 0.007595 Ccdc157 coiled-coil domain containing 157 (Ccdc157), transcNM_177616 6996703 0.097583 0.00256 Cgnl1 cingulin-like 1 (Cgnl1), mRNA. NM_026599 6961627 -0.21657 0.006846 Rgma RGM domain family, member A (Rgma), mRNA. NM_177740 6876212 -0.26299 0.008856 Eng endoglin (Eng), transcript variant 2, mRNA. NM_001146350 6901737 -0.27846 0.003653 Adh1 alcohol dehydrogenase 1 (class I) (Adh1), mRNA. NM_007409 6849891 -0.31566 0.008069 Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide NM_001101588 6933014 -0.32389 0.007769 Ptpn13 protein tyrosine phosphatase, non-receptor type 13 NM_011204 6988711 -0.33154 0.005308 Amica1 adhesion molecule, interacts with CXADR antigen 1 NM_001005421 6969996 -0.33503 0.00132 Olfr67 olfactory receptor 67 (Olfr67), mRNA. NM_013619 4339896 -0.36129 0.009661 --- AFFX-r2-Ec-bioB-M_at, bac_spike --- 6970217 -0.41828 0.008649 Olfr6 olfactory receptor 6 (Olfr6), mRNA. NM_206897 6768868 -0.47557 0.003268 Ggt5 gamma-glutamyltransferase 5 (Ggt5), mRNA. NM_011820 6832321 -0.48274 0.000162 Prr5 proline rich 5 (renal) (Prr5), mRNA. NM_146061 6847712 -0.5962 0.004338 Krtap16-4 keratin associated protein 16-4 (Krtap16-4), mRNA. NM_130873 6965984 -0.62063 0.002189 Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptideNM_028775 6940841 -0.68965 0.003078 Tgfbr3 transforming growth factor, beta receptor III (Tgfbr3 NM_011578 6852181 -0.69561 0.001802 Ehd3 EH-domain containing 3 (Ehd3), mRNA. NM_020578 6993138 -0.77799 0.003667 Ccr9 chemokine (C-C motif) receptor 9 (Ccr9), transcript NM_001166625 6827820 -0.80594 0.006604 Dzip1 DAZ interacting protein 1 (Dzip1), mRNA. NM_025943 6798392 -0.8525 0.002424 Vipr2 vasoactive intestinal peptide receptor 2 (Vipr2), mRNNM_009511 6764093 -0.87116 0.002894 Slamf7 SLAM family member 7 (Slamf7), mRNA. NM_144539 6907306 -0.88298 0.005434 Cd160 CD160 antigen (Cd160), transcript variant 1, mRNA NM_001163496 6846497 -0.89044 0.003147 St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 ( NM_018784 6876944 -0.96033 0.00613 Lypd6b LY6/PLAUR domain containing 6B (Lypd6b), mRNANM_027990 6902183 -0.99556 0.001567 Mcoln2 mucolipin 2 (Mcoln2), transcript variant 1, mRNA. NM_026656 6993142 -1.1357 0.000785 Cxcr6 chemokine (C-X-C motif) receptor 6 (Cxcr6), mRNANM_030712 6990416 -1.1449 0.003338 Nedd4 neural precursor cell expressed, developmentally doNM_010890 6968314 -1.38958 0.000888 Mctp2 multiple C2 domains, transmembrane 2 (Mctp2), mRNM_001024703 6900279 -1.64326 0.00305 AI504432 expressed sequence AI504432 (AI504432), non-codNR_033498 6946920 -1.75529 0.000364 Cd8a CD8 antigen, alpha chain (Cd8a), transcript variant NM_001081110 6931759 -2.16033 2.96E-06 Kit kit oncogene (Kit), transcript variant 1, mRNA. NM_001122733 6816160 -3.08382 0.000261 Gzma granzyme A (Gzma), mRNA. NM_010370