flow chemistry systems

easy-to-use, affordable and modular

Innovators in microfluidic solutions What are the Dolomite Flow Chemistry Systems?

The Dolomite Flow Chemistry Systems are easy-to-use, affordable modular systems for a range of flow chemistry applications. The systems allow multiple configurations for lab scale reactions and are upgradable for more functionality. The systems offer a wide range of reaction parameters with flow rates from <1.0µL/min to >10mL/min and temperatures from 1°C to 250°C.

3 entry level standard systems: Upgrade your system to increase its capability:

» System 1 (A&B): For beginners and educational needs. » Continuous Liquid Extraction: the Dolomite Membrane chip enables continuous work-up. » System 2 (A&B): For continuous reactions on a larger scale. » Sample Injection Valves: allows for small amounts of material » System 3 (A&B): For the widest range of chemistry - to be injected into the flow chemistry system. Ideal for reaction optimization, scale-up and multi-step reactions all in one. optimization and limited material. System A allows only PC control of pump. System B also allows » Pressurized Input: pressurize solvent/reagent bottles to manual control of pumps via the front panel. minimize input cavitation and gas bubble formation. Ideal for viscous or low boiling point liquids. Dolomite Flow Chemistry System Benefits:

• Wide range of reactor types: chips in glass, tubes in PTFE or A list of Dolomite Flow Chemistry System parts: Stainless Steel from 2.5µL to 16ml. • High performance pumps: smooth, chemically resistant syringe pumps can act as single shot or work together to operate System continuously up to 6 bar. • Temperature control options: choose from the TCU-125 for Standard System Parts 1A 1B 2A 2B 3A 3B chips (1°C to 125°C) or Hotplate for Tube Reactors (RT to Mitos Duo XS Basic Pump  2 2 250°C). • Rapid reaction configuration: allows for optimization on a Mitos Duo XS Pump  2 2 small scale, and direct scaling up of reactions in a safe and Meros TCU-125 (1 to 125°C)     reproducible manner. • Intuitive reaction automation: Flow Control Centre Advanced Hotplate (RT to 250°C)     PC Software allows accurate and reproducible reaction Tubing Starter Pack       automation with easy control of heating, pumping and key experiment parameters. Reagent/Solvent Bottles      

Why Flow Chemistry? Back Pressure Regulator       FCC Software       • Safer, cleaner chemistry via greater control of reaction temperature, stoichiometry, mixing and time. Reactor Options Access to increased chemical space. Reactions can be • 250µl Microreactor     performed that cannot be carried out under batch conditions. » Reactions generating unstable intermediates. Micromixer Chip     » Increased reaction rates by super-heating of reactions. T-Junction Chip     » Increased control of potentially hazardous reactions including exothermic and gas evolving reactions or reactions Long Channel Chip     with dissolved gases. 4ml Tube Reactor PTFE or SS    

16ml Tube Reactor PTFE or SS     System Upgrades

Additional Pump Module      

FCC Advanced Software      

Sample Injection (2 Valves)      

In-line Liquid Separation      

Pressurized Input      

Laptop      

 Standard  Optional

UK Head Office (Europe, S.E. Asia, Australasia, China, Middle East, Africa) North America Office t: +44 (0)1763 242 491 t: 617 848 1211 e: info@dolomite-microfluidics.com e: [email protected] w: www.dolomite-microfluidics.com

Japan Office (Japan, Korea and India Office Brasil Office (Latin America) Taiwan) t: +91 22 2686 4410 t: +55 11 5083 4963 t: 045 263 8211 e: [email protected] e: [email protected] e: [email protected]