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Flow Chemistry Presented by 22-23 MAY 2019 Prof Graz, Austria Das Weitzer FLOW A 2 day course presented by Prof. C Oliver Kappe & Dr Will Watson CHEMISTRY A 1 day Masterclass in Flow Chemistry presented by 22-23 MAY 2019 Prof. C Oliver Kappe NEW Flow Chemistry MASTERCLASS 24 MAY 2019 www.scientificupdate.com | [email protected] FLOW CHEMISTRY Multiple attendees discounts UP TO 15% 22-23 May 2019 Graz, Austria, Das Weitzer available INTRODUCTION COURSE OUTLINE Flow chemistry has been used in 1. Introduction to Flow Chemistry 4. High-Temperature / petrochemical and bulk chemical and Microreactors Pressure Flow Chemistry production for over 100 years but a. General references a. Flow chemistry in high-T/p process has only really been taken up b. Basic principles/advantages of windows (Novel Process Windows), in the pharmaceutical and fine microreactor technology: definitions, translating microwave protocols to chemical industries over the last mixing efficiency, flow regimes, heat flow, flow microwave chemistry 10 years or so. and mass transfer 5. Physical and Analytical Aspects This course aims to give an c. Equipment review: microreactors, of Flow Chemistry introduction to the subject and an mesofluidic/tubular reactors, cartridge- a. Handling solids in flow systems overview of the current state of the based systems b. Inline / online reaction monitoring art. A variety of chemical reactions d. Operative principles in flow: residence c. Regulatory aspects related to the in flow and how to translate a time, flow rate, back pressure, yield development of flow processes conventional reaction in to a flow 2. Microreactor Chemistry Concepts / Problem Session 2 – Group Work process will be described. Examples 6. Scaling up Flow Reactions a. Strongly exothermic and/or fast This also entails choosing the a. Industrial examples of microreactor reactions, “flash chemistry”, hazardous right type of flow reactor for technology chemistry and processes the chemistry, and a number of b. Choice of equipment b. Special techniques: flow different flow reactor systems c. Reaction conditions will be discussed and compared. photochemistry, electrochemistry, 7. Case Studies in Flow Chemistry Handling solids in flow systems, enzymatic reactions a. Examples from Pharmaceuticals inline and online monitoring of Problem Session 1 - Group Work and fine chemicals flow reactions will also be covered 3. General Flow Chemistry Examples Question and along with the hazards and pitfalls a. Homogeneous liquid-phase reactions Answer Session associated with scaling up flow b. Multi-phase reactions (liquid/liquid, reactions. liquid/solid) c. Reactions with gaseous components: gas, gas/liquid, gas/liquid/solid WHAT WILL ATTENDEES VENUE Das Weitzer We have organised a special GAIN? Grieskai 12-14, 8020 Graz, Austria accommodation rate of €125.50 per > What is flow chemistry/ night. Information on how to book microreaction technology and why www.hotelweitzer.com will be provided on your registration go flow confirmation. It’s a hotel that has been in the city > Which types of chemistry are most for more than 100 years, and will likely to benefit from being run in always be state-of-the-art. Modern flow systems mixed with traditional. Florian Weitzer > How to convert an existing lab is managing the hotel in the fourth reaction in to a flow process generation, and with character and contemporary ideas. And the Weitzer > The choice of flow reactors has even more to offer. Located right available and when the choice of in the Old Town, directly by the Mur, reactor is likely to be important just a few steps from the Kunsthaus > Practical tips associated with safety and very near to Schloßberg, and scale up of flow reactions Hauptplatz und Congress Graz. www.scientificupdate.com | [email protected] Start 9.00am - Wednesday 22 May Finish 3.30pm - Thursday 23 May Course dinner 7.30pm - Wednesday 22 May Course Fee: €1,899 Which includes comprehensive course manual, refreshments throughout the day, lunch and one course dinner. Course fee: €1,899 COURSE TUTORS REGISTRATION Professor C Oliver Kappe Dr Will Watson You can either use our fast online University of Graz Technical Director, booking system or mail or fax the C. Oliver Kappe received Scientific Update attached registration form to: his diploma- (1989) and his Will Watson gained his Scientific Update doctoral (1992) degrees in PhD in Organic Chemistry Maycroft Place, Stone Cross, Mayfield, organic chemistry from the from the University of East Sussex, TN20 6EW, UK University of Graz where he Leeds in 1980. He joined worked with Professor Gert Kollenz on the BP Research Centre at Sunbury- Fax Number +44 1435 872734 cycloaddition and rearrangement reactions on-Thames and spent five and a half How to Pay of acylketenes. After periods of postdoctoral years working as a research chemist When you register online, you can research work on reactive intermediates on a variety of topics including catalytic have the option to pay via credit card and matrix isolation spectroscopy with dewaxing, residue upgrading, synthesis (Mastercard or Visa). A receipted Professor Curt Wentrup at the University of of novel oxygenates for use as gasoline Queensland in Brisbane, Australia (1993- supplements, surfactants for use as invoice will be automatically generated 1994) and on synthetic methodology/ gasoline detergent additives and non- once paid and sent via email. Should alkaloid synthesis with Professor Albert linear optical compounds. your company wish to pay by cheque Padwa at Emory University in Atlanta, In 1986 he joined Lancaster Synthesis or bank transfer bank details will be USA (1994-1996), he moved back to the and during the next 7 years he was supplied with an invoice. University of Graz in 1996 to start his responsible for laboratory scale Bank Transfer or Cheque independent academic career. He obtained production and process research and his “Habilitation” in 1998 in organic development to support Lancaster’s Should your company wish to pay by chemistry and was appointed Associate catalogue, semi-bulk and custom cheque or bank transfer, on booking Professor in 1999. Since 2011 he holds synthesis businesses. In 1993 he was you can choose between paying in the position of Professor of “Technology appointed to the position of Technical either €, $ or £. All bank details will be of Organic Synthesis” (Organische Director, responsible for all Production supplied with an invoice. Synthesetechnologie) at the University of (Laboratory and Pilot Plant scale), Graz. He has spent time as visiting scientist/ Process Research and Development, Group Discounts professor at e.g. the Scripps Research Engineering and Quality Control. He Group discounts are available on two Institute (La Jolla, USA, Professor K. Barry helped set up and run the Lancaster or more attendees - see registration Sharpless, 2003), the Toyko Institute of Laboratories near Chennai, India and form. This offer only applies if bookings Technology (Toyko, Japan, Professor T. had technical responsibility for the are made simultaneously and from the Takahashi, 2008), the University of Sassari former PCR laboratories at Gainesville, same billing address. (Sassari, Italy, 2008), the Sanford-Burnham Florida. He joined Scientific Update as Institute for Medical Research (Orlando, Technical Director in May 2000. He is Confirmation of your registration USA, 2010) and the Federal University of Rio also involved in an advisory capacity These will be sent via email. de Janeiro (Rio de Janeiro, Brazil, 2013). in setting up conferences and in the Late Applications The co-author of more than 400 running of the events. He is also active For late applications, please publications, his main research in the consultancy side of the business. interests have in the past focused on register online or fax the completed multicomponent reactions, combinatorial @ [email protected] registration form, including credit chemistry and the synthesis of biologically card payment information. active heterocycles. More recently his Cancellations/Refunds research group has focused on the use Should you be unable to attend and of enabling and process intensification technologies for synthetic chemistry, cancel in writing no later than 1 month including microwave and continuous flow IN-HOUSE before the start of the course, Scientific processing. For his innovative work in Update will refund your registration microwave chemistry he received the 2004 COURSE less £300 (or equivalent in €/$) Prous Science Award from the European For 8+ people contact us to discuss processing fee. Unfortunately refunds Federation for Medicinal Chemistry and the holding this event In-House - are not possible after that date. 2010 Houska Prize (€100.000) in addition to [email protected] Substitutions can be made at any time. a number of other awards. www.scientificupdate.com | [email protected] Optional Flow Chemistry MASTERCLASS 24 May 2019 University of Graz, Austria NEW! Although attendees of the Flow Chemistry Course will be well acquainted with the basic principles of flow chemistry and the advantages it can offer, the real “tricks of the trade” can only be learned in the lab. This one-day flow chemistry lab session, hosted by the “Center for Continuous Flow Synthesis and Processing” (CCFLOW), offers a unique hands-on experience of flow chemistry in action. Participants will learn to select and operate a suitable flow reactor, gaining an understanding of the equipment DETAILS and techniques involved. The experienced team at CCFLOW
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