day 2Course FLOW 2020 CHEMISTRY
Flow Chemistry MASTERCLASS Available
1 Day Session ele ti e e i t e l l e i t i t 1989 - 2019
www.scientificupdate.com [email protected] FLOW CHEMISTRY & MASTERCLASS
A 2 day course
INTRODUCTION COURSE OUTLINE
Flow chemistry has been used in 1. Introduction to Flow Chemistry 4. High-Temperature / petrochemical and bulk chemical and Microreactors Pressure Flow Chemistry production for over 100 years but a. General references a. Flow chemistry in high-T/p process has only really been taken up b. Basic principles/advantages of windows (Novel Process Windows), in the pharmaceutical and fine microreactor technology: definitions, translating microwave protocols to chemical industries over the last mixing efficiency, flow regimes, heat flow, flow microwave chemistry 10 years or so. and mass transfer 5. Physical and Analytical Aspects c. Equipment review: microreactors, This course aims to give an of Flow Chemistry mesofluidic/tubular reactors, cartridge- introduction to the subject and an a. Handling solids in flow systems based systems overview of the current state of the b. Inline / online reaction monitoring d. Operative principles in flow: residence art. A variety of chemical reactions c. Regulatory aspects related to the time, flow rate, back pressure, yield in flow and how to translate a development of flow processes conventional reaction in to a flow 2. Microreactor Chemistry Concepts / Problem Session 2 – Group Work Examples process will be described. 6. Scaling up Flow Reactions a. Strongly exothermic and/or fast This also entails choosing the a. Industrial examples of microreactor reactions, “flash chemistry”, hazardous right type of flow reactor for technology chemistry and processes the chemistry, and a number of b. Choice of equipment b. Special techniques: flow different flow reactor systems c. Reaction conditions photochemistry, electrochemistry, will be discussed and compared. enzymatic reactions 7. Case Studies in Flow Chemistry Handling solids in flow systems, a. Examples from Pharmaceuticals Problem Session 1 - Group Work inline and online monitoring of and fine chemicals flow reactions will also be covered 3. General Flow Chemistry Examples Question and along with the hazards and pitfalls a. Homogeneous liquid-phase reactions Answer Session associated with scaling up b. Multi-phase reactions (liquid/liquid, flow reactions. liquid/solid) c. Reactions with gaseous components: “An excellent gas, gas/liquid, gas/liquid/solid course summarising WHAT WILL the state of the art in flow chemistry. ATTENDEES Highly recommended.” GAIN? DevchemPty Ltd > What is flow chemistry/ microreaction technology and why go flow > Which types of chemistry are most likely to benefit from being run in flow systems > How to convert an existing lab reaction in to a flow process IN-HOUSE > The choice of flow reactors COURSE available and when the choice of For 8+ people contact us to discuss reactor is likely to be important holding this event In-House - > Practical tips associated with safety [email protected] and scale up of flow reactions
www.scientificupdate.com [email protected] Registration 8.30 Course commences 9.00 Day 1 Course adjourns 4.00 on Day 2 Course fees include a comprehensive course manual, refreshments throughout each day, lunches and one course dinner on the first evening
For all prices and dates please refer to our website IT’S EASY TO REGISTER ONLINE COURSE TUTORS REGISTRATION
Professor C Use our fast online booking Oliver Kappe system by visiting University of Graz Dr C. Oliver C. Oliver Kappe Kappe www.scientificupdate.com received his Alternatively you can mail or fax the diploma- (1989) and his doctoral attached registration form to: (1992) degrees Scientific Update in organic chemistry from the University Maycroft Place, Stone Cross, of Graz where he worked with Professor Dr Will Watson Dr Will Watson Gert Kollenz on cycloaddition and Technical Director, Mayfield, East Sussex, TN20 6EW, UK rearrangement reactions of acylketenes. Scientific Update Fax Number +44 1435 872734 After periods of postdoctoral research Will Watson gained work on reactive intermediates and matrix his PhD in Organic How to Pay isolation spectroscopy with Professor Chemistry from the When you register online, you can Curt Wentrup at the University of University of Leeds in 1980. He joined Queensland in Brisbane, Australia (1993- the BP Research Centre at Sunbury- have the option to pay via credit 1994) and on synthetic methodology/ on-Thames and spent five and a half card (Amex, MasterCard or Visa). A alkaloid synthesis with Professor Albert years working as a research chemist Padwa at Emory University in Atlanta, on a variety of topics including catalytic receipted invoice will be automatically USA (1994-1996), he moved back to dewaxing, residue upgrading, synthesis generated once paid and sent via the University of Graz in 1996 to start of novel oxygenates for use as gasoline email. Should your company wish to his independent academic career. He supplements, surfactants for use as obtained his “Habilitation” in 1998 in gasoline detergent additives and pay by cheque or bank transfer, on organic chemistry and was appointed non-linear optical compounds. booking, bank details will be supplied Associate Professor in 1999. Since 2011 In 1986 he joined Lancaster Synthesis he holds the position of Professor of and during the next 7 years he was with an invoice. “Technology of Organic Synthesis” responsible for laboratory scale (Organische Synthesetechnologie) at the production and process research and Group Discounts University of Graz. He has spent time development to support Lancaster’s Group discounts are available on two as visiting scientist/professor at e.g. the catalogue, semi-bulk and custom or more attendees - see registration Scripps Research Institute (La Jolla, USA, synthesis businesses. In 1993 he was Professor K. Barry Sharpless, 2003), the appointed to the position of Technical form. This offer only applies if bookings Toyko Institute of Technology (Toyko, Director, responsible for all Production are made simultaneously and from the Japan, Professor T. Takahashi, 2008), the (Laboratory and Pilot Plant scale), University of Sassari (Sassari, Italy, 2008), Process Research and Development, same billing address. the Sanford-Burnham Institute for Medical Engineering and Quality Control. He Research (Orlando, USA, 2010) and the helped set up and run the Lancaster Confirmation of your registration Federal University of Rio de Janeiro (Rio de Laboratories near Chennai, India and These will be sent via email. Janeiro, Brazil, 2013). had technical responsibility for the The co-author of more than 400 former PCR laboratories at Gainesville, Late Applications publications, his main research Florida. He joined Scientific Update as For late applications, please interests have in the past focused on Technical Director in May 2000. He is multicomponent reactions, combinatorial also involved in an advisory capacity register online or fax the completed chemistry and the synthesis of biologically in setting up conferences and in the registration form, including credit running of the events. He is also active active heterocycles. More recently his card payment information. research group has focused on the use in the consultancy side of the business. of enabling and process intensification Cancellations/Refunds technologies for synthetic chemistry, [email protected] Should you be unable to attend and cancel including microwave and continuous flow @ processing. For his innovative work in in writing no later than 1 month before microwave chemistry he received the 2004 the start of the course, Scientific Update Prous Science Award from the European will refund your registration less £300.00 Federation for Medicinal Chemistry and (or equivalent in €/$) processing fee. the 2010 Houska Prize (€100.000) in Unfortunately refunds are not possible addition to a number of other awards. after that date. Substitutions can be made at any time.
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www.scientificupdate.com [email protected] Optional Flow Chemistry MASTERCLASS
Although attendees of the Flow Chemistry Course will be well acquainted with the basic principles of flow chemistry and the advantages it can offer, the real “tricks of the trade” can only be learned in the lab. This one-day flow chemistry lab session, hosted by the “Center for Continuous Flow Synthesis and Processing” (CCFLOW), offers a unique hands-on experience of flow chemistry in action.
Participants will learn to select and operate a suitable flow reactor, gaining an understanding of the equipment DETAILS and techniques involved. The experienced team at CCFLOW will offer practical advice on the set-up and VENUE execution of continuous processes. In the state-of-the-art University of Graz, Austria laboratory space, small groups of participants will see live demonstrations of flow reactor technologies, including: TUTOR Professor C. Oliver Kappe > Single- and multiphase flow chemistry and members of his research > Gas-liquid flow chemistry, mass flow controllers group > High-temperature/pressure process windows Masterclass fee includes: > Glass, Hastelloy and silicon carbide plate-based flow > one-day flow chemistry platforms lab session > Flow photochemistry and electrochemistry > coffee/tea refreshment > In-line and at-line process analytics (IR, NMR, UV, UHPLC) breaks throughout the day > Liquid-liquid and gas-liquid separations > buffet lunch > Piston-, syringe- and peristaltic pumps > 3D printed reactors (steel, caramics)
“It was overall an excellent scientific update and the CCFlow lab visit a must!” Janssen
HOW DO I ATTEND? Places for the Masterclass are limited and first option will go to those delegates who are booked onto the Flow Chemistry Course. If you are booked onto the course you have the option to select the Masterclass at an additional cost of €700 per person. If you would like to attend only the Masterclass, please email [email protected] to register your interest. You will be placed on a waiting list where we will keep you posted – the cost will be €850 per person.
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