HORMONE REPLACEMENT THERAPY Brand Active Ingredient(s) Description Strength(s) Frequency of Dosing ESTROGEN (ORAL) CENESTIN Synthetic conj. estrogens, A Tablets 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg Once daily ENJUVIA Synthetic conj. estrogens, B Tablets 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg Once daily ESTRACE Estradiol (micronized) Tablets 0.5mg, 1mg, 2mg Once daily FEMTRACE Estradiol Tablets 0.45mg, 0.9mg, 1.8mg Once daily MENEST Esterified estrogens Tablets 0.3mg, 0.625mg, 1.25mg, 2.5mg Once daily OGEN Estropipate 1 Tablets 0.625mg, 1.25mg, 2.5mg Once daily ORTHO-EST Estropipate 1 Tablets 0.625mg, 1.25mg Once daily PREMARIN Conj. estrogens Tablets 0.3mg, 0.45mg, 0.625mg, Once daily 0.9mg, 1.25mg, 2.5mg ESTROGEN (TRANSDERMAL) ALORA Estradiol Patch (matrix) 0.025, 0.05, 0.075, 0.1mg/day Twice weekly CLIMARA Estradiol Patch (matrix) 0.025, 0.0375, 0.05, 0.06, 0.075, Once weekly 0.1mg/day DIVIGEL Estradiol Gel (topical) 0.25, 0.5, 1mg/packet Once daily ELESTRIN Estradiol Gel (topical) 0.87g/pump Once daily ESTRADERM Estradiol Patch (reservoir) 0.05, 0.1mg/day Twice weekly ESTRASORB Estradiol Emulsion (topical) 1.7 4g/pouch 2 pouches once daily ESTROGEL Estradiol Gel (topical) 1.25g/pump 1 pump once daily EVAMIST Estradiol Spray (topical) 1.53mg/spray Initially 1 spray daily; may increase to 2–3 sprays if needed MENOSTAR Estradiol Patch (matrix) 0.014mg/day Once weekly VIVELLE Estradiol Patch (matrix) 0.05, 0.1mg/day Twice weekly VIVELLE-DOT Estradiol Patch (matrix) 0.025, 0.0375, 0.05, 0.075, 0.1mg/day Twice weekly ESTROGEN (VAGINAL) ESTRING Estradiol Ring 7.5micrograms/24hours Once every 90 days FEMRING Estradiol Ring 0.05mg/day, 0.1mg/day Once every 3 months PREMARIN Conj. estrogens Cream 0.625mg/g Daily VAGIFEM Estradiol Vaginal tablets 25micrograms Once daily for 2 weeks, then twice weekly PROGESTOGEN (ORAL) AYGESTIN Norethindrone acetate Tablets 5mg Once daily PROMETRIUM Progesterone (micronized) Capsules 100mg, 200mg Once daily PROVERA MPA Tablets 2.5mg, 5mg, 10mg Once daily ESTROGEN + PROGESTOGEN (ORAL) ACTIVELLA Estradiol + norethindrone acetate Tablets 0.5mg + 0.1mg; 1mg + 0.5mg Once daily ANGELIQ Estradiol + drospirenone Tablets 1mg + 0.5mg Once daily FEMHRT Norethindrone acetate + Tablets 0.5mg + 2.5micrograms Once daily, continuously ethinyl estradiol 1mg + 5micrograms Note: Progestin listed first PREFEST Estradiol (3 tabs); then Tablets 1mg; then 1mg + 0.09mg Once daily, sequentially estradiol + norgestimate (3 tabs) PREMPHASE Conj. estrogens (14 tabs); then Tablets 0.625mg; then 0.625mg + 5mg Once daily, sequentially conj. estrogens + MPA (14 tabs) PREMPRO Conj. estrogens + MPA (28 tabs) Tablets 0.3mg + 1.5mg, 0.45mg + 1.5mg, Once daily, continuously 0.625mg + 2.5mg, 0.625mg + 5mg ESTROGEN + PROGESTOGEN (TRANSDERMAL) CLIMARA PRO Estradiol + levonorgestrel Patch (matrix) 0.045mg + 0.015mg/day Once weekly COMBIPATCH Estradiol + Patch (matrix) 0.05mg + 0.14mg/day Twice weekly norethindrone acetate 0.05mg + 0.25mg/day ESTROGEN + ANDROGEN (ORAL) ESTRATEST H.S. Esterified estrogens + Tablets 0.625mg + 1.25mg Once daily methyltestosterone ESTRATEST Esterifed estrogens + Tablets 1.25mg + 2.5mg Once daily methyltestosterone NOTES This is not an inclusive list. Indications vary among products. For more information see the product listings in this section or contact the manufacturer. For combination products, the estrogen component is listed first. Strengths listed are not necessarily the same as the dosage. Frequency of dosing is that used for HRT; other uses may have other frequencies. Some products are given cyclically. 1 Formerly piperazine estrone sulfate. Tablet strengths given as mg sodium estrone sulfate. Matrix patch: Estradiol is embedded in the adhesive layer that is applied directly to the skin. Reservoir patch: Estradiol is contained in a drug reservoir and its release is controlled by a co-polymer membrane; contains more layers than matrix patch. MPA = medroxyprogesterone acetate. (Rev. 11/2009)