MENOPAUSAL HORMONE THERAPY
Name Hormone (s) Vehicle Dosage ( approx E2 level by column) Frequency 10-20pg/ml 20-30pg/ml 35pg/ml 50-60pg/ml 75pg/ml 100pg/ml ESTROGEN (ORAL) CENESTIN Synthe c conj. estrogens, A Tablet 0.3mg 0.45mg 0.625mg 0.9mg 1.25mg Once daily ENJUVIA Synthe c conj. estrogens, B Tablet 0.3mg 0.45mg 0.625mg 0.9mg 1.25mg Once daily ESTRACE (or generic) Estradiol (micronized) Tablet 0.5mg 1mg 2mg Once daily MENEST Esterified estrogens Tablet 0.3mg 0.625mg 1.25mg 2.5mg Once daily OGEN Estropipate Tablet 0.625mg 1.25mg Once daily PREMARIN Conj. estrogens Tablet 0.3mg 0.45mg 0.625mg 0.9mg 1.25mg 2.5mg Once daily
ESTROGEN (TRANSDERMAL) VIVELLE-DOT Estradiol Patch (dot matrix) 0.025mg/day 0.0375mg 0.05mg 0.075mg 0.1mg Twice weekly MINIVELLE Estradiol Patch (dot matrix) 0.0375mg 0.05mg 0.075mg 0.1mg Twice weekly ALORA Estradiol Patch 0.025mg/day 0.05mg 0.075mg 0.1mg Twice weekly ESTRADERM (generic) Estradiol Patch (reservoir) 0.05mg/day 0.1mg Twice weekly CLIMARA Estradiol Patch 0.025mg/day 0.0375mg 0.05mg/0.06mg 0.075mg 0.1mg Once weekly MENOSTAR Estradiol (indicated for osteoporosis preven on) Patch 0.014mg/d Once weekly
DIVIGEL Estradiol Gel (topical) 0.25mg/packet 0.5, 1mg / packet Once daily ELESTRIN Estradiol Gel (topical) 0.87g/pump 2 pumps Once daily ESTRASORB Estradiol Emulsion (topical) 1.74g/pouch 2 pouches once daily ESTROGEL Estradiol Gel (topical) 1.25g/pump 1 pump once daily EVAMIST Estradiol Spray (topical) 1.53mg/spray 2-3 sprays 1–3 sprays daily
FEMRING Estradiol Vaginal Ring 0.05mg/day 0.1mg q 3 months
COMBINED ESTROGEN + TESTOSTERONE (ORAL) Estratest (generic) Esterified Estrogens/Methyltestosterone Tablet "h.s."0.625mg + 1.25mg 1.25/2.5mg Once daily
COMBINED ESTROGEN + PROGESTIN (ORAL) ACTIVELLA E2 + norethindrone acetate Tablet 0.5mg + 0.1mg 1mg + 0.5mg Once daily ANGELIQ Estradiol + drospirenone Tablet 0.5mg + 0.25mg 1mg + 0.5mg Once daily FemHRT Ethinyl estradiol + Norethindrone acetate 0.5mg + 2.5mcg 1mg + 5mcg PREFEST Estradiol (3 tabs); then estradiol + norges mate (3 tabs) Tablet 1mg; then 1mg + 0.09mg Once daily, sequen ally PREMPHASE Conj. estrogens (14 tabs); then conj. estrogens + MPA Tablet 0.625mg; then 0.625mg + Once daily, sequen ally (14 tabs) 5mg PREMPRO Conj. estrogens + MPA (28 tabs) Tablet 0.3mg + 1.5mg 0.45mg + 1.5mg 0.625mg + 2.5mg, 0.625mg Once daily, con nuously + 5mg
COMBINED ESTROGEN + PROGESTIN (TRANSDERMAL) CLIMARA PRO Estradiol + levonorgestrel Patch (matrix) 0.045mg + 0.015mg/day Once weekly COMBIPATCH Estradiol + norethindrone acetate Patch (matrix) 0.05mg + 0.14mg/day Twice weekly 0.05mg + 0.25mg/day Twice weekly
VAGINAL ESTROGEN for VAGINAL sxs only. Minimal expected serum level change at these dose levels. ESTRING Estradiol 2mg Ring 7.5mcg/d Change every 90 days ESTRACE vaginal E2 0.01% Cream 1/2 gram biw 1/2 gram daily (50mcg/d) 0.5g twice weekly. Load w/ daily for (100mcg/g) (14mcg E2/d) 2 weeks PREMARIN Conj. estrogens 0.625mg/g Cream 1/2 g biw (140mcg E2 0.5gm twice weekly a er load equiv/d) VAGIFEM Estradiol 10mcg Vaginal tablets 3mcg E2/d Twice weekly. Load w/ daily for 2 weeks
PROGESTIN (ORAL) AYGESTIN Norethindrone acetate Tablet 5mg (OC uses Daily 1mg, POP uses 0.35mg) PROMETRIUM Progesterone (oral micronized) Capsule 100mg, 200mg, Once daily for HT. 400mg for 2nd 300mg amenorrhea PROVERA MPA (medroxyprogesteone acetate) Tablet 2.5mg, 5mg, Daily for HT. Up to 20mg d x 7 d 10mg then 20mg daily x 21d for DUB MEGACE Megestrol Tablet 20mg, 40mg up to qid for DUB MIRENA IUS Levonorgestrel IUD 5 years (off label for menopausal use)