Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant
Author Manuscript Published OnlineFirst on December 19, 2016; DOI: 10.1158/1078-0432.CCR-16-2054 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 1 Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant 2 Prostate Cancer Patient-Derived Xenografts 3 4 Hung-Ming Lam1,2*, Ryan McMullin3*†, Holly M. Nguyen1, Ilsa Coleman4, Michael Gormley5, 5 Roman Gulati4, Lisha G. Brown1, Sarah K. Holt1, Weimin Li5, Deborah S. Ricci6, Karin 6 Verstraeten7, Shibu Thomas5, Elahe A. Mostaghel4, 8, Peter S. Nelson4, 8, Robert L. Vessella1, 7 9, and Eva Corey1 8 9 Affiliation of authors: 1Department of Urology, University of Washington School of 10 Medicine, Seattle, Washington; 2State Key Laboratory of Quality Research in Chinese 11 Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of 12 Science and Technology, Macau (SAR), China; 3LabConnect, Seattle, Washington; 4Fred 13 Hutchinson Cancer Research Center, Seattle, Washington; 5Janssen Research & 14 Development, Spring House, Pennsylvania; 6Janssen Research & Development, Raritan, 15 New Jersey; 7Janssen Research & Development, Beerse, Belgium; 8Department of 16 Medicine, University of Washington, Seattle, Washington; 9Department of Veterans Affairs 17 Medical Center, Seattle, Washington 18 19 *Co-primary lead authors 20 †Current affiliation: Janssen Research & Development, Spring House, Pennsylvania 21 22 23 Running title (60 characters max): Abiraterone Response and Resistance 24 25 Keywords: abiraterone acetate, prostate cancer, xenografts, biomarkers, androgen 26 receptor, glucocorticoid receptor, castration resistance 27 28 Grant/funding support: The work was supported by The Richard M. Lucas Foundation, the 29 Prostate Cancer Foundation, SU2C, a NIH PO1 CA085859, and the PNW Prostate Cancer 1 Downloaded from clincancerres.aacrjournals.org on September 23, 2021.
[Show full text]