BMC Bioinformatics BioMed Central Research article Open Access GIFtS: annotation landscape analysis with GeneCards Arye Harel*1, Aron Inger, Gil Stelzer1, Liora Strichman-Almashanu1, Irina Dalah1, Marilyn Safran1,2 and Doron Lancet1 Address: 1Department of Molecular Genetics, Weizmann Institute of Science Rehovot 76100, Israel and 2Department of Biological Services (Bioinformatics Unit), Weizmann Institute of Science, Rehovot 76100, Israel Email: Arye Harel* -
[email protected]; Aron Inger -
[email protected]; Gil Stelzer -
[email protected]; Liora Strichman-Almashanu -
[email protected]; Irina Dalah -
[email protected]; Marilyn Safran -
[email protected]; Doron Lancet -
[email protected] * Corresponding author Published: 23 October 2009 Received: 22 February 2009 Accepted: 23 October 2009 BMC Bioinformatics 2009, 10:348 doi:10.1186/1471-2105-10-348 This article is available from: http://www.biomedcentral.com/1471-2105/10/348 © 2009 Harel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Gene annotation is a pivotal component in computational genomics, encompassing prediction of gene function, expression analysis, and sequence scrutiny. Hence, quantitative measures of the annotation landscape constitute a pertinent bioinformatics tool. GeneCards® is a gene-centric compendium of rich annotative information for over 50,000 human gene entries, building upon 68 data sources, including Gene Ontology (GO), pathways, interactions, phenotypes, publications and many more.