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Supplementary Figure 3. Hepatic Gene Expression Profiles of Drug-Treated Db/Db and Untreated Db/+ Compared to Untreated Db/Db

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Supplementary Figure 3. Hepatic Gene Expression Profiles of Drug-Treated Db/Db and Untreated Db/+ Compared to Untreated Db/Db Supplementary Figure 3. Hepatic gene expression profiles of drug-treated db/db and untreated db/+ compared to untreated db/db fold changes estimate fold changes estimate affy ID#genbank ID# symbol gene name RWT + RWT + db/db affy ID#genbank ID# symbol gene name RWT + RWT + db/db 145 Cellular Processes 4 chemotaxis 16 apoptosis 102938_atAB009687 Lect2 leukocyte cell-derived chemotaxin 2 -1,7-2,1 -1,5 -1,0 374 102016_atM61737 Fsp27 fat specific gene 27 5,43,1 3,6 -1,3 20 103448_atM83218 S100a8 S100 calcium binding protein A8 (calgranulin 1,1-1,0 1,8 -1,1 17 103029_atD86344 Pdcd4 programmed cell death 4 1,2-1,1 -1,4 1,6 174 97360_atAI841689 Cklfsf3 chemokine-like factor super family 3 1,11,1 1,6 1,0 11 93968_atAA870917 Pdcd5 programmed cell death 5 -1,01,5 1,0 -1,1 241 103240_f_atAF017258 Ear2 eosinophil-associated, ribonuclease, RNase A 1,2-1,0 1,9 1,0 35 93766_atU32170 Rgn regucalcin -1,2-1,3 -1,6 -1,0 1356 38 cytoskeleton 93869_s_atU23781 Bcl2a1d Bcl-2-related protein A1 (BFL-1 protein) 1,01,1 1,6 1,0 24 160065_s_atAI837625 Csrp1 cysteine and glycine-rich protein 1 1,21,2 1,7 1,0 21 161500_i_atAV102186 Bad Bcl-associated death promoter -1,1-1,1 -1,1 1,5 50 96298_f_atAF020185 Dnclc1 dynein, cytoplasmic, light chain 1 -1,6-1,1 1,2 -1,1 315 161980_f_atAV373612 Bag3 Bcl2-associated athanogene 3 1,1-1,3 1,7 1,2 30 99441_atAW123852 Gphn gephyrin 1,01,0 -1,5 1,5 85 93536_atL22472 Bax Bcl2-associated X protein 1,21,3 2,0 -1,1 64 93571_atM74773 Spnb2 spectrin beta 2 1,11,2 1,5 1,1 148 93697_atU63387 Cbx4 chromobox homolog 4 (Drosophila Pc class) -1,5-1,7 -1,9 -1,2 62 102043_atAF047704 Tuft1 tuftelin 1 -1,01,1 1,9 1,7 54 93093_atU35623 Mcl1 myeloid cell leukemia sequence 1 1,2-1,0 1,6 1,4 66 162379_r_atAV245272 Vim vimentin 1,1-1,0 1,0 1,6 20 97825_atAI854029 Perp-pen p53 apoptosis effector related to Pmp22 1,21,7 1,3 -1,3 196 160150_f_atAW125626 Cnn3 calponin 3, acidic -1,1-1,6 -1,2 1,2 261 99994_atAF041376 Cidea cell death-inducing DNA fragmentation factor, 5,49,5 2,0 1,0 28 101578_f_atM12481 Actb actin, beta, cytoplasmic 2,21,0 1,6 1,5 119 102114_f_atAI326963 Angptl4 angiopoietin-like 4 -1,11,5 -1,0 -1,3 108 96573_atM21495 Actg actin, gamma, cytoplasmic -1,21,1 1,6 -1,1 573 96119_s_atAA797604 Angptl4 angiopoietin-like 4 1,11,6 1,1 -1,5 156 103574_atAI841606 AbLIM1 actin-binding LIM protein 1 1,31,5 1,5 1,2 27 97890_atAW046181 Sgk serum/glucocorticoid regulated kinase -1,11,2 1,5 1,0 34 104578_f_atAI195392 Actn1 actinin, alpha 1 1,11,4 1,6 1,7 66 101521_atAB013819 Birc5 baculoviral IAP repeat-containing 5 -1,11,2 1,5 -1,1 16 93364_atX59990 Catna1 catenin alpha 1 1,11,1 1,6 1,1 102 40 cell adhesion 98107_atAW123801 Coro1c coronin, actin binding protein 1C 1,21,3 1,7 1,1 71 161996_f_atAV328452 Bcan brevican -1,6-1,2 -1,8 -1,6 25 96865_atM60474 Marcks myristoylated alanine rich protein kinase C 1,31,5 1,8 1,1 27 104083_atAI853217 Cdh5 cadherin 5 1,31,2 1,6 1,2 33 94991_atAW046661 Synpo synaptopodin 1,42,1 1,6 -1,0 16 92835_atAI840501 Cml1 camello-like 1 -2,4-3,1 -3,1 1,1 588 96426_atU38967 Tmsb4x thymosin, beta 4, X chromosome 1,31,0 2,7 1,3 109 95016_atD50086 Nrp neuropilin 1,01,7 1,1 2,0 74 93100_atX13297 Acta2 actin, alpha 2, smooth muscle, aorta 1,11,0 1,8 1,3 24 100120_atL17324 Nid1 nidogen 1 1,41,3 1,7 1,1 11 92608_atD88793 Csrp1 cysteine and glycine-rich protein 1 1,01,1 1,5 1,0 29 93318_atU91513 Ninj1 ninjurin 1 -1,2-1,5 -1,3 -1,2 203 103330_atAI838709 Strbp spermatid perinuclear RNA binding protein 1,11,6 1,4 1,1 30 96774_atAW047139 Plekhc1 pleckstrin homology domain containing, family -1,2-1,3 -1,5 1,8 78 100446_r_atX91825 Sprr1b small proline-rich protein 1B -1,11,1 1,6 -1,1 1204 92558_atM84487 Vcam1 vascular cell adhesion molecule 1 1,2-1,0 1,9 1,2 18 100554_atAF053367 Pdlim1 PDZ and LIM domain 1 (elfin) 1,01,0 1,8 1,2 109 161188_f_atAV238648 Lamb3 laminin, beta 3 1,12,2 -1,0 -1,1 51 160417_atU86090 Kif5b kinesin family member 5B -1,21,0 -1,0 1,6 25 92759_atU43298 Lamb3 laminin, beta 3 1,57,2 1,1 -1,3 39 98462_s_atAI322968 Klc8 kinesin-like protein 8 -1,3-1,3 -1,2 -1,6 41 102805_atM77196 Ceacam1 CEA-related cell adhesion molecule 1 -1,6-1,8 -2,1 -1,5 278 99458_i_atX70764 Mark2 MAP/microtubule affinity-regulating kinase 2 -1,21,1 1,5 1,1 104 102806_g_atM77196 Ceacam1 CEA-related cell adhesion molecule 1 -1,7-1,8 -2,1 -1,5 130 97447_atAI836718 Map1lc3a microtubule-associated protein 1 light chain 3 1,91,5 1,4 -1,1 106 101908_s_atAF101164 Ceacam2 CEA-related cell adhesion molecule 2 -1,4-1,5 -1,7 -1,5 135 100915_atAW125698 Myh9 myosin heavy chain IX 1,11,1 1,7 -1,0 155 93063_atU82624 App amyloid beta (A4) precursor protein 1,21,3 1,8 1,1 155 98409_atL00923 Myo1b myosin IB -1,4-2,9 -2,0 1,2 220 92593_atD13664 Osf2-pen osteoblast specific factor 2 (fasciclin I-like) 1,71,2 2,0 -1,2 20 92254_atM55253 Myo5b myosin Vb 1,31,6 1,5 -1,3 77 93353_atAF013262 Lum lumican -1,1-1,1 1,7 1,4 22 160532_atM22479 Tpm1 tropomyosin 1, alpha 1,31,4 2,5 1,1 75 160583_atAA880988 Xlkd1 extra cellular link domain-containing 1 1,41,3 1,9 -1,2 18 94270_atM22832 Krt1-18 keratin complex 1, acidic, gene 18 -1,01,3 2,7 1,0 209 104337_f_atAW208938 Pkp2 plakophilin 2 1,71,4 1,4 -1,1 116 101009_atX15662 Krt2-8 keratin complex 2, basic, gene 8 1,21,5 3,1 -1,1 377 102852_atM31131 Cdh2 cadherin 2 -1,2-1,1 -1,3 2,1 64 100342_i_atM28729 Tuba1 tubulin, alpha 1 1,21,0 1,6 1,2 82 98549_atM77123 Vtn vitronectin -1,5-2,0 -1,6 1,1 2239 100343_f_atM28729 Tuba1 tubulin, alpha 1 1,1-1,0 1,6 1,0 301 100990_g_atAJ001373 Itgb1bp1 integrin beta 1 binding protein 1 -1,2-1,1 1,6 -1,1 38 98759_f_atM28727 Tuba2 tubulin, alpha 2 1,11,1 1,7 1,1 540 94963_atAI462105 Vcl vinculin 1,11,6 1,6 1,3 63 94835_f_atM28739 Tubb2 tubulin, beta 2 4,22,8 6,4 -1,8 395 104257_g_atAI120844 Pscdbp pleckstrin homology, Sec7 and coiled-coil 1,21,1 1,3 1,5 24 160462_f_atAW050256 Tubb3 tubulin, beta 3 2,42,0 3,4 -1,3 150 92880_atM38337 Mfge8 milk fat globule-EGF factor 8 protein 1,11,6 1,7 1,1 170 94788_f_atX04663 Tubb5 tubulin, beta 5 1,71,8 2,5 1,0 256 95706_atX16834 Lgals3 lectin, galactose binding, soluble 3 1,11,2 5,3 1,0 22 160461_f_atAW215736 Tubb6 tubulin, beta 6 1,31,6 2,4 -1,2 67 160099_atAF026799 Lgals4 lectin, galactose binding, soluble 4 1,11,7 -1,1 -1,3 54 5 peroxisome organization and biogenesis 99669_atX15986 Lgals1 lectin, galactose binding, soluble 1 3,92,9 4,5 -2,0 107 98965_atAC002397 Grcc3f, gene rich cluster, C3f gene 1,33,0 1,9 -1,4 141 95566_atAF050666 Gpld1 glycosylphosphatidylinositol specific -1,4-4,6 -2,5 1,3 288 95074_atAW125309 Pxf peroxisomal farnesylated protein 1,51,5 1,2 -1,4 96 160179_atAW124122 Col12a1 collagen, type XII, alpha1 -1,11,0 -1,1 1,6 54 104098_atL28835 Pxmp2 peroxisomal membrane protein 2 -1,0-1,3 -1,7 -1,1 1281 103709_atAA763466 Col1a1 procollagen, type I, alpha 1 1,11,2 1,8 1,1 58 94491_atAW123194 Pex13 peroxisomal biogenesis factor 13 1,21,6 -1,1 1,0 35 94305_atU03419 Col1a1 procollagen, type I, alpha 1 1,41,8 6,1 1,1 39 99469_atAW121865 Pex6 peroxisomal biogenesis factor 6 1,51,1 -1,1 1,2 127 101130_atX58251 Col1a2 procollagen, type I, alpha 2 1,11,2 2,4 1,1 45 299 Environmental Information Processing 161984_f_atAV234303 Col3a1 procollagen, type III, alpha 1 1,01,1 1,5 -1,0 10 3 angiogenesis 98331_atX52046 Col3a1 procollagen, type III, alpha 1 -1,01,3 3,0 -1,1 34 94392_f_atU22516 Ang angiogenin -1,8-1,4 -1,4 2,6 348 101093_atM15832 Col4a1 procollagen, type IV, alpha 1 1,61,5 2,6 1,2 47 101735_f_atU22519 Ang2 angiogenin, ribonuclease A family, member 2 -1,3-1,2 -1,1 1,8 50 101039_atX04647 Col4a2 procollagen, type IV, alpha 2 1,21,6 1,8 1,1 93 160484_atAI840118 Rtn4 reticulon 4 1,52,3 1,3 -2,0 185 92567_atL02918 Col5a2 procollagen, type V, alpha 2 1,21,2 2,3 1,1 17 17 blood coagulation 101110_atAF064749 Col6a3 procollagen, type VI, alpha 3 1,11,2 1,8 1,2 57 99638_atD17546 Col18a1 procollagen, type XVIII, alpha 1 -1,2-1,3 -1,6 -1,1 878 102291_atM23109 F9 coagulation factor IX -1,2-1,4 -1,8 1,1 335 93934_atAF072128 Cldn2 claudin 2 -1,2-1,3 -1,1 -1,6 195 97435_atD10071 F13b coagulation factor XIII, beta subunit -1,4-1,7 -1,7 -1,1 197 96868_atAI196896 Fgb fibrinogen, B beta polypeptide -1,3-1,4 -1,5 1,3 672 25 cell cycle 93096_atAA986050 FGG fibrinogen, gamma polypeptide -1,3-1,8 -1,6 1,4 1362 96146_atD83745 Btg3 B-cell translocation gene 3 -1,11,2 1,6 1,6 16 161458_atAV298640 F7 coagulation factor VII -1,4-1,5 -1,4 1,2 534 101906_atAA032310 Smc4l1 SMC4 structural maintenance of 1,01,8 1,6 1,0 23 92918_atU66079 F7 coagulation factor VII , serum prothrombin -1,5-2,6 -1,9 1,2 201 160623_atAI847045 Cdkl2 cyclin-dependent kinase-like 2 (CDC2-related 1,21,5 1,5 1,1 21 102748_atU52925 F5 coagulation factor V -1,7-2,0 -1,7 1,1 317 96319_atAW061324 Cdc20 cell division cycle 20 homolog (S.
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