The Editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following colleagues who acted as Guest Editors for Specific Fields in 1991.

Martin W. Adler Gary L. Henderson Elaine Sanders-Bush Edson X. Albuquerque Barry Hotter Lewis S. Seiden Joan Heller Brown Robert M. Joy Jerry Sepinwall Thomas F. Burks Suzanne G. Laychock Theodore A. Slotkin Peter Cervoni Benedict R. Lucchesi Larry Stein Marlene L. Cohen Michael I. Luster Boris Tabakoff Richard A. Cohen Harry S. Margolius Robert Taber Charles A. Craig John C. McGiff A. E. Takemon Linda A. Dykstra Kenneth P. Minneman R. Clinton Webb Harold Feinberg Alan S. Nies Thomas C. Westfall Ray W. Fuller Michael Peach Grant R. Wilkinson James W. Gibb Arthur Raines Raymond Winquist John W. Hadden Mark J. Reasor Paul H. Wooley

Additionally, sincere thanks are due to 567 of our colleagues not on the Editorial Advisory Board who reviewed articles for the Journal in 1 991 . Their contributions are acknowledged individually in the Annual Report of The Journal to The Board of Publications Trustees of the American Society for Pharmacology and Experimental Therapeutics. INDEX

Volume 261 , April-June, 1992

Abe, Y., Kitada, Y. and Narimatsu, A.: Ben- Adenylyl cyclase Aldosterone, antihypertensive effects of Y- eficial effect of MCI-154, a cardi- brown fat, perinatal changes, beta adre- 27152 (rats, dogs), 730 otonic agent, on ischemic contractile noceptors (rats), 633 Alfentanil failure and myocardial acidosis of dog coupling of beta-i and -3 adrenergic re- -reinforced responding, effects of bupren- hearts: Comparison with dobuta- ceptors, agonist exposure (rats), 638 orphine (monkeys), 311 mine, milrinone and pimobendan, Adipocytes, beta-i and -3 adrenergic recep- use of 2-hydroxypropyl-3-cyclodextrin, 1087 tors, adenylyl cyclase, agonist expo- intrathecal drug vehicle (rats), 592 Abernethy, D.R., see Andrawis, N. S., 879 sure (rats), 638 Allan, A. M., Baier, L. D. and Zhang, X.: Acetaminophen, sulfate and 3’-phosphoad- Adipose tissue, brown fat adenylyl cyclase, Effects of lorazepam tolerance and enosine 5 ‘ -phosphosulfate, homeo- perinatal changes, beta adrenocep- withdrawal on GABAA receptor-op- stasis (rats), 1015 tom (rats), 633 erated chloride channels, 395 Acetaminophen glucuronide, impaired bili- Adler-Graschinsky, E., see Elgoyhen, A. B., Allen, G. T., see Harris, D. N., 131 ary excretion, phenobarbital, liver 534 Allen, M. S., see Takada, K., 138 (rats), 1022 Adrenoceptors Allergic reaction, control of contractile re- Acetylcholine alpha, subtypes involved in emetic action sponse, histamine N-methyltransfer- cholecystokinin receptors, mediation of (dogs), 746 ase, trachea (guinea pigs), 1268 contraction, ileum longitudinal mus- alpha-i, block of angiotensin Il-mediated Alm, P., see Holmquist, F., 795 cle myenteric plexus (guinea pigs), vasoconstriction (humans), 879 Alonso, M. J., Salaices, M., Sanchez-Ferrer, 1056 atpha-2 C. F. and Mann, J.: Predominant role neurokinin receptors and mucosal ion agonists, opposite rank order of potency for nitric oxide in the relaxation in- transport, jejunum (pigs), 1213 (rats), 1080 duced by acetylcholine in cat cerebral NMDA-increased release from striatum agonists and antagonists, intrathecal arteries, 12 and cortex, augmentation by choline administration (rats), 764 Alper, R. H., see Itoh, H., 225 (rats), 1122 central actions of nitroglycerin, cortex Alzheimer’s disease, neocortical pyramidal relaxation of cerebral arteries, role for membranes (rats), 1187 neurones, 5-HT1A receptors, intras- nitric oxide (cats), 12 clonidine effects, chronic congestive triatal volkensin (rats), 1273 releasing properties, benzimidazolone de- heart failure (rats), 1129 Amenta, F., see Ricci, A., 830 rivatives, ileum (guinea pigs), 412 kidney (rats), 1050 Amiloride, lithium and, collecting tubule 1-a-Acetylmethadol, differential influence beta transport enzymes (rats), 701 of N-dealkylation, stimulus proper- adenylyl cyclase, adipocytes (rats), 638 -y-Aminobutryic acid, chronic benzodiaze- ties, opioid agonists (monkeys), 278 inhibition of positive inotropic re- pine administration, PK11195, at- a1-Acid glycoprotein, stereoselective phar- sponses, catecholamines in papillary tenuation of chronic effects of bra- macokinetics, propranolol, age and zepam (mice), 285 muscle (rabbits), 1160 gender influences (humans), 1181 ‘y-Aminobutyric acid, -stimulated chloride perinatal changes, brown fat adenylyl Acidosis, myocardial, ischemic contractile flux, benzodiazepine receptor occu- cyclase (rats), 633 failure, beneficial effect of MCI-154 pancy (rats), 1106 propranolol, stereoselective pharmaco- (dogs), 1087 p-Aminohippurate, kidney multidrug trans. kinetics (humans), 1181 Acquired immunodeficiency syndrome, porter, cyclosporine effect, colchicine regulation by thyroid hormone, heart transport of recombinant CD4, secretion (rats), 50 and kidney (rats), 951 through the blood.brain barrier Ammon, H. P. T., see Safayhi, H., 1143 prejunctional, chronic epinephrine treat- (rats), 1175 Amphetamine ment, sympathetic neurotransmis- ACTH, cholecystokinin-A and -B receptor acute administration, regulation of dopa- sion in mesentery (rats), 924 antagonists, fl-endorphin secretion mine synthesis (rats), 567 Aging (rats), 454 locomotor activity, acute sensitivity, Adenosine diphosphate, purinergic receptor gender and, stereoselective pharmacoki- FAST and SLOW mice, 525 netics, propranolol (humans), 1181 expression, K562 cells, 580 region-specific regulation, clozapine 1, ex- Adenosine triphosphatase increased sensitivity to anesthetic effect, trastriatal dopamine D2 receptors collecting tubule transport enzymes, lith- phenobarbital, BN/BiRij rats, 81 (rats), 1282 ium and amiloride (rats), 701 toluene and trichloroethylene metabo- sensitization of locus ceruleus neurons, inhibitor of H,K-ATPase, AHR-9294, lism, liver (rats), 869 during withdrawal (rats), 476 gastric HC1 secretion (rats, dogs), 737 Agonist, -related differences in relationship, -stimulated motor activity, block by quin- Adenosine triphosphate cAMP content and protein kinase ac- pirole microinjection, AlO dopamine -sensitive K channels, inhibition by gli- tivity, trachealis (dogs), 1260 region (rats), 811 benclamide, cardiac muscle (guinea AHR-9294, inhibitor of H,K-ATPase, gas- Amphetamines pigs), 540 tric HC1 secretion (rats, dogs), 737 discriminative stimulus effects of mor- toxicity of 1-methyl-4-phenyl-1,2,3,6-tet- Airway phine, agonist and antagonist effects, rahydropyridine, primary cultures, inhibitory effects, cromakalim and BRL mu opioids (rats), 246 astrocytes (mice), 44 38227 (guinea pigs, humans), 429 lasting effects of 3,4-methylenedioxyme- Adenylate cyclase relaxant properties of S-nitrosothiols thamphetamine, central serotonergic beta adrenergic receptors and, regulation (guinea pigs), 154 neurons, nonhuman primates, 616 of ontogeny, thyroid hormone (rats), Albuquerque, E. X., see Pereira, E. F. R., Amygdala, role of different brain structures, 951 331 morphine withdrawal syndrome highly potent beta-2 sympathomimetics, Alcohol, -preferring C57BL/6 mice, hypo- (rats), 669 conversion to partial agonists, tra- thalamic 9-endorphin system, sensi- Analgesia chea relaxants (guinea pigs), 258 tivity to ethanol, 788 /3-endorphin and morphine, release of 1292 1992 Index 1293

met-enkephalin, forebrain (rats), synthase activity, calmodulin inhibi- smoking: Effect of varying 9-tet- 1028 tors (rats), 553 rahydrocannabinol content and inhibition ofenkephalin-metabolizing en- rings, relaxant effects, 9-carbolines (rats), number ofpuffs, 114 zymes, RB 101 (mice, rats), 181 534 pharmacodynamics and pharmacoki- Aracava, Y., see Pereira, E. F. R., 331 Baclofen, modeling ofeffect site equilibrium netics, morphine, spontaneously hy- Arch, J. R. S., see Taylor, S. G., 429 kinetics, pharmacodynamics, quan- pertensive and normotensive rats, Argatroban, comparative antithrombotic ef- titative EEG effect measures (rats), 290 fects, femoral vein platelet-rich mu- 88 pharmacologic activity of CI-977 (mon- ral thrombosis model (hamster), 895 Baggs, R. B., see Finkelstein, M. B., 1248 keys), 1044 Arginine, N-substituted compounds, blood Baier, L. D., see Allan, A. M., 395 Anazodo, M, I., see Safayhi, H., 1143 pressure (rats), 875 Bailey, J., see Reenstra, W. W., 737 Baroreflex, changes produced by serotoner- Anders, M. W., see Finkelstein, M. B., 1248 Armando, I., see Kvetnansky, R., 899 gic or catecholaminergic lesions, nu- Andersson, K.-E., see Holmquist, F., 795 Aronstam, R. S., see Pereira, E. F. R., 331 cleus tractus solitarius (rats), 225 Andrawis, N. S., Craft, N. and Abernethy, Artery Barreiro, E. J., see Pereira, E. F. R., 331 D. R.: Calcium antagonists block an- cerebral Barrett, J. B., see Takada, K., 138 giotensin Il-mediated vasoconstric- relaxation induced by acetylcholme, Bay K 8644, dual effects of endothelins, tion in humans: Comparison with role for nitric oxide (cats), 12 field-stimulated ileum (guinea pigs), their effect on phenylephrine-in- susceptibility of vasodilator nerve, cab- 1253 duced vasoconstriction, 879 cium antagonists (dogs), 234 Beaune, P. H., see Flinois, J.-P., 381 Anesthetics coronary Behavior alteration of general potency, agonists activation of relaxation cascade, brief buprenorphine’s effects on self-adminis- and antagonists, polyamine binding electrical pulses (cattle), 209 tration, smoked cocaine base, PCP/ site of NMDA receptor (mice), 304 antithrombotic activity, D-methyl- ethanol/saccharin (monkeys), 26 increased sensitivity to phenobarbital, ag- phenylalanyl-prolyl-arginal (dogs), increased rates of punished responding, ing BN/BiRij rats, 81 546 buspirone-like compounds (rats), 513 Angiotensin characterization of 5-HT receptors reduction of spinal cord blood flow, plate- pressor and renal vasoconstrictor effects, (cattle), 601 let-activating factor, receptor mech- NGnitroL.arginine, sympathetic serotonin receptors, smooth muscle anism (rats), 1064 nervous system (rats), contraction (dog, pig), 856 240 schedule-controlled, punishment, fl-car- -renin system inhibition, reduction, gly- pulmonary, endothelial dopamine DA-1 boline injections (monkeys), 138 receptor sites (rabbits), 830 cine-induced glomerular hyperfiltra- varying tetrahydrocannabinol content, tion (rats), 96 regional differences in effects of septic number of puffs, marijuana smoking Angiotensin II shock, vascular reactivity (rabbits), (humans), 114 959 amplification of arterial contractile re- B#{233}langer,P. M., see Parent, C., 780 sponse, norepinephrine, protein ki- Arthus, M.-F., see Kinter, L. B., 462 Belknap, J. K., see Janowsky, A., 1282 nase C (rabbits), 835 Arts, K. S., Fujimoto, J. M. and Tseng, L. Benavides, J., see Perrier, M. L., 324 F.: Involvement of dynorphin A and -mediated vasoconstriction, block by cal- Ben-Harari, R. R., see Tagliente, T. M., 755 not substance P in the spinal antian- cium antagonists (humans), 879 Bennett, B. M., McDonald, B. J. and St. algesic action of capsaicin against potentiation of vasopressor response of James, M. J.: Hepatic cytochrome P. morphine-induced antinociception in lung, estradiol, U-46619 (rats), 686 450-mediated activation of rat aortic receptor antagonist SC-51316 (rats), 1037 mice, 643 guanylyl cyclase by glyceryl trini- receptor antagonists DUP 753 and PD 4-(Arylamino)quinolines, inhibitor of H,K- trate, 716 121981, cardiac angiotensin receptors ATPase, AHR-9294, gastric HCI se- Benzimidazolone, derivates, acetylcholine (rabbits), 931 cretion (rats, dogs), 737 releasing properties, ileum (guinea Antibiotics, gentamicin, surface binding and Aspirin, .induced gastric damage, reduction pigs), 412 intracellular uptake, LLC-PK, cells, by interleukin lfl, corticosteroids Benzodiazepines 1200 (rats), 1238 buspirone-like compounds, increased Anticoagulants, antithrombotic activity, D- Asthma rates, punished responding (rats), methyl-phenylalanyl-prolyl-arginal beta-2 sympathomimetics, conversion to 513 (dogs), 546 partial agonists, trachea relaxants chronic administration, PK11195, atten- Anticonvulsants, activation of serotonergic (guinea pigs), 258 uation of chronic effects of borazepam neurons, carbamazepine and antie- phasic responses to carbachol, augmen- (mice), 285 pilepsirine (rats), 652 tation by cooling, trachea (guinea lorazepam tolerance and withdrawal, GA- Antidepressants, stimulants and, sensitiza- pigs), 755 BAA receptor-operated chloride tion, locus ceruleus neurons (rats), Astrocytes, toxicity of 1-methyl-4-phenyl-1, channels (mice), 395 476 2,3,6-tetrahydropyridine, primary modeling of pharmacodynamic interac- Antiepilepsirine, carbamazepine and, acti- cultures (mice), 44 tion, differences in intrinsic efficacy vation of serotonergic neurons (rats), Atchison, W. D., see Hare, M. F., 166 (rats), 56 652 Atrial natriuretic peptide, localization and receptor occupancy Antihypertensives, Y-27152 (rats, dogs), 730 characterization, neutral metalboen- functional effects of ligands, differing Antinociception dopeptidase, kidney (rats), 1231 intrinsic efficacies (mice), 1113 morphine-induced, dynorphin A, spinal Autoradiography GABA-stimulated chloride flux (rats), antianalgesic action of capsaicin endothelial dopamine DA-1 receptor sites, 1106 (mice), 643 pulmonary artery (rabbits), 830 role of GABA receptor/chloride channel pharmacologic activity of CI-977 (mon- functional effects of endothelin-1, penile complex, tolerance to ethanol, cross- keys), 1044 tissues (humans, rabbits), 795 tolerance to diazepam and pentobar- spinal morphine-induced, naloxone and neuroleptic nonresponsive and responsive bital (rats), 108 norbinaltorphimine, spinal dynor- lines, D, and D2 dopamine receptor Berberine, mechanism of vasodilating ac- phin A (1-17) (mice), 146 distribution (mice), 341 tion, inositol lipid signaling system Aoki, K., see Nakajima, T., 730 Avey, L. B., see Buckpitt, A., 364 (guinea pigs), 318 Aorta Axon, emulsifier for intravenous cyclo- Bergman, J., see Spealman, R. D., 607 guanylyl cyclase, hepatic cytochrome sporin, inhibition of neurite out- Berman, D. M., see Bova, S., 318 P450-mediated activation, glyceryl growth, neuroblastoma, 803 Bernardino, V., see Chiu, P. J. S., 994 trinitrate (rats), 716 Azorlosa, J. L., Heishman, S. J., Stitzer, M. Bertalmio, A. J., Medzihradsky, F., Winger, impairment of constitutive nitric oxide L. and Mahaffey, J. M.: Marijuana G. and Woods, J. H.: Differential in- 1294 Index Vol. 261

fluence of N.dealkylation on the Bowen, D. M., see Francis, P. T., 1273 jejunal mucosa through an action on stimulus properties of some opioid Bowyer, J. F., Newport, G. D., Lipe, G. W. enteric neurons, 1206 agonists, 278 and Frame, L. T.: A further evalua- Brown, D. R., see Parsons, A. M., 1213 Bettendorf, A. F., see Yan, Q..S., 652 tion of the effects of K depolariza- Brown, R., see Jansen, A., 154 Bevan, J. A.: see Henrion, D., 835 tion on glutamate-evoked 3H-dopa- Buciak, J. L., see Pardridge, W. M., 1175 Bhargava, H. N., Villar, V. M., Rahmani, N. mine release from striatal slices, 72 Buckle, D. R., see Taylor, S. G., 429 H. and Larsen, A. K.: Time course of Bradykinin, pharmacologic characteriza- Buckpitt, A., Buonarati, M., Avey, L. B., the distribution of morphine in brain tion, muscularis mucosae, colon (rab- Chang, A. M., Morin, D. and Plopper, regions and spinal cord after intra- bits),1136 C. G.: Relationship of cytochrome venous injection to spontaneously Brain P450 activity to Clara cell cytotoxic- hypertensive and normotensive Wis- calcium channels (rats), 324 ity. II. Comparison of stereoselectiv- tar-Kyoto rats, 1008 carbon monoxide-induced damage, ity of naphthalene epoxidation in Bhargava, H. N. and Villar, V. M.: Phar- NMDA receptor antagonists (mice), lung and nasal mucosa of mouse, macodynamics and pharmacoki- 349 hamster, rat and rhesus monkey, 364 netics of intravenously administered catecholamine and serotonin metabolism, Buckpitt, A., see Plopper, C. G., 353 morphine in spontaneously hyper- endotoxin-induced activation, inter- Bueno, L., see Gue, M., 850 tensive and normotensive Wistar- leukin 1 (mice), 964 Bumetanide, sodium and bicarbonate secre- Kyoto rats, 290 D1 and D2 dopamine receptor distribution, tion, substance P, jejunal mucosa Bhatnagar, R. K., see Ma, S., 1187 neuroleptic nonresponsive and re- (pigs), 1206 Bicarbonate, sodium and, substance P, je- sponsive lines (mice), 341 Bu#{241}ag,R. D., see Itoh, H., 225 junal mucosa (pigs), 1206 differential activation of dopamine, nic- Buonarati, M., see Buckpitt, A., 364 Bichet, D. G., see Kinter, L. B., 462 otine, morphine (rats), 484 Buprenorphine Bickel, W. K., see Oliveto, A. H., 885 glutamate-evoked dopamine release from acute effects, methadone-maintained vol- Bigelow, G. E., see Preston, K. L., 62 striatal slices, potassium depolariza- unteers, 985 Bigelow, G. E., see Strain, E. C., 985 tion (rats), 72 alfentanil- and cocaine-reinforced re- Bile nucleus tractus solitarius, serotonergic or sponding (monkeys), 311 impaired excretion, acetaminophen glu- catecholaminergic lesions (rats), 225 discrimination of agonist-antagonist curonide, phenobarbital (rats), 1022 region-specific regulation, clozapine 1, ex- opioids, two-choice saline-hydromor- secretion, regulation by prolactin, post- trastriatal dopamine D2 receptors phone (humans), 62 partum (rats), 560 (rats), 1282 modulation of discriminative stimulus ef- sequestration of organic cations, acidified role of different structures, expression, fects, cocaine, mu and kappa opioids hepatic endocytic vesicles (rats), 1 physical morphine withdrawal syn- (monkeys), 607 Blame, E. H., see Olins, G. M., 1037 drome (rats), 669 self-administration of smoked cocaine Blanc, G., see Vezina, P., 484 time course of morphine distribution, in- base, phencyclidine, ethanol and sac- Blandford, D. E., see Smyth, D. D., 1080 travenous injection (rats), 1008 charm (monkeys), 26 Blehm, D. J., see Olins, G. M., 1037 Brain stem, opioid and nicotinic analgesic Burger, R. L., see Yan, Q.-S., 652 Blood.brain barrier, transport of recombi- and hyperalgesic loci (rats), 707 Burgio, D., see McNamara, P. J., 918 nant CD4 (rats), 1175 Brat, D. J., Windebank, A. J. and Brimijoin, Burkhart-Kasch, S., see Phillips, T. J., 525 Blood flow, spinal cord, platelet-activating S.: Emulsifier for intravenous cyclo- Burton, M. B., see Percy, W. H., 1136 Buspirone, -like compounds, increased factor, receptor mechanism (rats), sporin inhibits neurite outgrowth, rates, punished responding (rats), 1064 causes deficits in rapid axonal trans- Blood pressure port and leads to structural abnor- 513 acute pressor response, sympathoadrenal malities in differentiating N1E.115 2,3-Butanedione monoxime, dual action on K current, T cells (humans), 438 stimulation, cycbosporine (rats), 994 neuroblastoma, 803 Butanol, locomotor activity, acute sensitiv- cardiovascular and subjective effects, in- Breathing, see Respiration ity, FAST and SLOW mice, 525 travenous cocaine, morphine combi- Bretazenil Butorphanol, discrimination of agonist-an- nations (humans), 623 benzodiazepine receptor occupancy tagonist opioids, two-choice saline- d-myo-inositol-1,2,6-trisphosphate ef- functional effects of ligands, differing hydromorphone (humans), 62 fects, neuropeptide Y-induced poten- intrinsic efficacies (mice), 1113 Buyukuysal, R. L., see Ulus, I. H., 1122 tiation, vasoconstrictor agents (rats), GABA-stimulated chloride flux (rats), Buzalsky, S., see Carroll, M. E., 26 1147 1106 Bylund, D. B., see Pleus, R. C., 271 N-substituted arginine compounds (rats), Brice#{241}o, E., see Campos, H. A., 943 Byrnes, J. J., see Miller, L. G., 285 875 Brimijoin, S., see Brat, D. J., 803 pressor and renal vasoconstrictor effects, BRL 38227, cromakalim and, inhibitory ef- Cadmium, susceptibility to Ca antago- N#{176}nitro-L-arginine (rats), 240 fects, airways (guinea pigs, humans), nists, vasodilator nerve, cerebral ar- renal sympathetic nerve activity, cboni- 429 teries (dogs), 234 dine effects, chronic congestive heart 2-Bromo-2-chboro-1,1-difluoroethene, glu- Caffeine failure (rats), 1129 tathione and cysteine conjugates, drug discrimination (humans), 885 Blood vessel, activation of relaxation cas- nephrotoxicity, 1248 locomotor activity, acute sensitivity, cade, coronary arteries, brief electri- Bronchi, inhibitory effects, cromakalim and FAST and SLOW mice, 525 cal pulses (cattle), 209 BRL 38227 (guinea pigs, humans), Calcium Bboomquist, W. E., see Cohen, M. L., 202 429 adenosine diphosphate purinergic recep- BMY-14802, modulation of NMDA-induced Bronchoconstriction tor expression, K562 cells, 580 neuronal activation, CA3 dorsal hip- control of contractile response, histamine amplification of arterial contractile re- pocampus, sigma ligands (rats), 123 N-methyltransferase, trachea sponse, angiotensin II, norepineph- Bond, J., see Taylor, S. G., 429 (guinea pigs), 1268 rine (rabbits), 835 Bonetti, E. P., see Facklam, M., 1113 pharmacological characterization, SQ 33, antagonists Borghgraef, P., see Van Wauwe, J., 773 261 and SQ 33,552 (humans, rats, block of angiotensin Il-mediated vaso- Boswellic acids, novel nonredox inhibitors guinea pigs, mice), 131 constriction (humans), 879 of 5-lipoxygenase, 1143 Brooks, D. P., see Wang, Y.-X., 96 susceptibility of vasodilator nerve, cer- Bova, S., Padrini, R., Goldman, W. F., Ber- Brouwer, K. L. R., see Studenberg, S. D., ebral arteries (dogs), 234 man, D. M. and Cargnelli, G.: On the 1022 myosin phosphorylation-independent mechanism of vasodilating action of Brown, D. R., Parsons, A. M. and O’Grady, contraction, induction by phorbol es-

berberine: Possible role of inositol S. M.: Substance P produces sodium ter, vascular smooth muscle (rats), lipid signaling system, 318 and bicarbonate secretion in porcine 497 1992 Index 1295

phasic responses to carbachol, augmen- beta adrenoceptor-mediated positive mo- -deficient liver, cytochrome P450 2C11, tation by cooling, trachea (guinea tropic responses, inhibition by 5-HT, development of cirrhosis (rats), 373 pigs), 755 papillary muscle (rabbits), 1160 NMDA-increased acetylcholine release, phosphorylation-independent vascular cerebral, endotoxin-induced activation, striatum and cortex (rats), 1122 contraction, receptor agonists (rats), interleukin 1 (mice), 964 Christensen, B., Refsum, H., Garras, A. and 506 chronic epinephrine treatment, failure to Ueland, P. M.: Homocysteine reme- renal handling of electrolytes, acute ef- alter prejunctional adrenoceptor thylation during nitrous oxide expo- fect.s, gentamicin (rats), 38 modulation, sympathetic neurotrans- sure of cells cultured in media con- Calcium channel blockers mission in mesentery (rats), 924 taming various concentrations of fol- clentizem effect, arterial pressure, renal plasma dopa responses during stress, sym- ates, 1096 function (rats), 470 pathoneural activity, tyrosine hy- Chung, I., see Schlichter, L. C., 438 decrease in tryptophan hydroxylase activ- droxylation (rats), 899 CI 977 ity, calcium channel blockers, 3,4- Cathapermal, S., see Thomas, G., 875 modulation of discriminative stimulus ef- methylenedioxymethamphetamine Cations, organic fects, cocaine, mu and kappa opioids (rats), 586 interference with transport by nicotine, (monkeys), 607 metabolism rate of oxodipine (rats, hu- plasma, habitual tobacco smokers pharmacologic activity (monkeys), 1044 mans), 381 (rats), 21 Cimetidine, pharmacokinetics during lacta- Calcium channels sequestration by acidified hepatic endo- tion (rats, rabbits), 918 blocking action of terodiline, urinary cytic vesicles, implications, biliary Cirrhosis, development, cytochrome p450 bladder, single smooth muscle cells excretion (rats), 1 2C11, choline-deficient liver (rats), (guinea pigs), 724 transport and MDR gene expression, 373 dihydropyridine-resistant, brain slices postnatal development, kidney Clara cells (rats), 324 (mice), 1222 cytotoxicity Calcium current, electromechanical effects CD4, transport through blood-brain barrier cytochrome P-450, naphthalene paren- teral administration (mice, rats, of celikalim, atrial and ventricular (rats), 1175 muscle (cats), 1153 Celikalim, electromechanical effects, atrial hamsters), 353 Callahan, M. J., see Davis, R. E., 1044 and ventricular muscle (cats), 1153 cytochrome P-450, naphthalene epoxi- dation (mice, hamsters, rats, mon- Calmodulin, inhibitors, impairment, consti- Cell culture keys), tutive nitric oxide synthase activity LLC-PK1 cells, transport of salicylic acid 364 in aorta (rats), 553 through monolayers, 518 Clarkson, C. W., see Crumb, W. J., Jr., 910 Clentiazem, arterial pressure and renal Campbell, S., see Kinter, L. B., 462 nitrous oxide exposure, homocysteine re- Campos, H. A. and Briceflo, E.: Two models function, normotensive and hyper- methylation, folates, 1096 of peripheral sympathetic autoregu- tensive rats, 470 Central nervous system, actions of nitro- Clonidine lation: Role of neuronal histamine, glycerin, clonidine binding sites, cor- 943 alpha adrenoceptor subtypes, emetic ac- tex membranes (rats), 1187 Cano, C. and Malik, K. U.: Adenosine recep- tion (dogs), 746 Cephalosporins, transepithelial transport, tor-mediated alterations in prosta- binding sites in cortex membranes, cen- monolayers, epithelial cell line, 195 cyclin production and cardiac func- tral actions, nitroglycerin (rats), 1187 Cerebrospinal fluid, modeling of effect site tion in the isolated rabbit heart, 660 intrathecal administration, alpha-2 ago- equilibrium kinetics, pharmacody- Cantrill, E., see Murray, M., 373 nists and antagonists (rats), 764 namics, bacbofen (rats), 88 Capsaicin, spinal antianalgesic action, dy- opposite rank order of potency, water and Chabin, M., see Flinois, J.-P., 381 norphin A, morphine-induced antin- solute excretion (rats), 1080 Chandan, R., see Parsons, A. M., 1213 ociception (mice), 643 renal sympathetic nerve activity, natri- Chang, A. M., see Buckpitt, A., 364 Carbachol uresis and diuresis, chronic conges- Chang, R. S. L., see Scott, A. L., 931 highly potent beta-2 sympathomimetics, tive heart failure (rats), 1129 Chatton, J.-Y. and Roch-Ramel, F.: Non- conversion to partial agonists, tra- sensitization of locus ceruleus neurons, ionic diffusion of salicylic acid chea relaxants (guinea pigs), 258 during withdrawal (rats), 476 through MDCK cell monolayers, phasic responses, inhibition by nifedipine, Clotting factor, release, inhibition, vaso- 1071 trachea (guinea pigs), 755 pressin antagonist (monkeys), 462 Chatton, J.-Y. and Roch-Ramel, F.: Trans- Carbamazepine, antiepilepsirine and, acti- Clozapine 1, region-specific regulation, ex- port of salicylic acid through mono- vation of serotonergic neurons (rats), trastriatal dopamine D2 receptors layers of a kidney epithelial cell line 652 (rats), 1282 (LLC-PK1), 518 fl-Carbolines Cocaine Chaudhry, A., Lahners, K. N. and Granne- punishment of schedule-controlled be- block of amphetamine-stimulated motor man, J. G.: Perinatal changes in the havior (monkeys), 138 activity, quinpirole microinjection, coupling of beta1- and beta3 adrener- relaxant effects, aortic rings (rats), 534 AlO dopamine region (rats), 811 Carbon monoxide, -induced brain damage, gic receptors to brown fat adenylyl buprenorphine’s effects on self-adminis- NMDA receptor antagonists (mice), cyclase, 633 tration, phencyclidine, ethanol and 349 Chestnut, D. H., see Widness, J. A., 977 saccharin (monkeys), 26 Cardiotonic agents, MCI-154, myocardial Chiu, P. J. S., Vemulapalli, S., Sabin, C., intravenous, morphine combinations, car- acidosis, ischemic contractile failure Rivelli, M., Bernardino, V. and Sy- diovascular and subjective effects (dogs), 1087 bertz, E. J.: Sympathoadrenal stim- (humans), 623 Cargnelli, G., see Bova, S., 318 ulation, not endothelin, plays a role in utero exposure, effect on neonatal Carlsson, S., see Feng, Q. P., 1129 in acute pressor response to cycbo- breathing (guinea pigs), 420 Carmona, G. N., see Carroll, M. E., 26 sporine in anesthetized rats, 994 major metabolites, sodium channel block- Carroll, M. E., Carmona, G. N., May, S. A., Chloride, GABA-stimulated flux, benzodi- ing properties, single cardiac myo- Buzalsky, S. and Larson, C.: Bupren- azepine receptor occupancy (rats), cytes (guinea pigs), 910 orphine’s effects on self-ad.ministra- 1106 modulation of discriminative stimulus ef- tion of smoked cocaine base and or- Chloride channels, GABAA receptor-oper- fects, mu and kappa opioids (mon. ally delivered phencyclidine, ethanol ated, lorazepam tolerance and with- keys), 607 and saccharin in rhesus monkeys, 26 drawal (mice), 395 punishment of schedule-controlled be- Casley, D. J., see Kanazawa, M., 1231 Cholecystokinin, -A and -B receptor antag- havior, fl-carboline injections (mon- Catecholamines onists, fl-endorphin secretion, pitui- keys), 138 baroreflex changes, nucleus tractus soli- tary (rats), 454 -reinforced responding, effects of bupren- tarius (rats), 225 Choline orphine (monkeys), 311 1296 Index Vol. 261

self-administration, choice between pharmacological characterization, SQ 33, opioid agonist, in rhesus monkeys, smoked and intravenous (humans), 261 and SQ 33,552 (humans, rats, 1044 841 guinea pigs, mice), 131 dDAVP, inhibition ofcbotting factor release, sensitization of locus ceruleus neurons, protein kinase activity and, agonist-re- vasopressin antagonist (monkeys), during withdrawal (rats), 476 bated differences, trachealis (dogs), 462 Coccini, T., see Rizzi, C. A., 412 1260 De Boer, A. G., see Mandema, J. W., 88 Coene, M.-C., see Van Wauwe, J., 773 Cyclic nucleotide phosphodiesterase, relax- Debonnel, G., see Monnet, F. P., 123 Coffman, W. J., see Jackson, C. V., 546 ant effects of fl-carbolines, aortic Defecation, stress-induced, role of Cohen, M. L., Robertson, D. W., Bloomqu- rings (rats), 534 serotonin3 receptor (rats), 297 ist, W. E. and Wilson, H. C.: fl-Cycbodextrin, use of 2-hydroxypropyl-fl- de Fiebre, C. M. and Collins, A. C.: Classical LY215840, A potent 5-hydroxytrypt- cycbodextrin, intrathecal drug vehi- genetic analyses of responses to nic- amine (5-HT)2 receptor antagonist, cle, opioids (rats), 592 otine and ethanol in crosses derived blocks vascular and platelet 5-HT2 Cyclooxygenase from long- and short-sleep mice, 173 novel nonredox inhibitors of 5-lipoxygen- receptors and delays occlusion in a Deka-Starosta, A., see Kvetnansky, R., 899 ase, boswellic acids, 1143 rabbit model of thrombosis, 202 Delanney, L. E., see Di Monte, D. A., 44 pharmacological characterization, SQ 33, Cohen, M. L., see Cushing, D. J., 856 Del Rio, C., see Gue, M., 850 Colatsky, T. J., see Lodge, N. J., 1153 261 and SQ 33,552 (humans, rats, de Montigny, C., see Monnet, F. P., 123 guinea pigs, mice), 131 Colchicine, secretion by kidney multidrug de Paulis, T., see Janowsky, A., 1282 Cyclosporine transporter, effect of cycbosporine Desiderio, D. M., see Relling, M. V., 491 acute pressor response, sympathoadrenal (rats), 50 Desipramine, sensitization of locus ceruleus Collen, D., see Imura, Y., 895 stimulation (rats), 994 neurons, during withdrawal (rats), Collier, W. L., see Ricci, A., 830 colchicine secretion by kidney multidrug 476 Collins, A. C., see de Fiebre, C. M., 173 transporter (rats), 50 De Waele, J.-P., Papachristou, D. N. and intravenous, emulsifier, inhibition of neu- Colon Gianoulakis, C.: The alcohol-prefer- rite outgrowth, 803 pharmacologic characterization, muscu- ring C57BL/6 mice present an en- laris mucosae (rabbits), 1136 Cysteine, conjugates, 2-bromo-2-chboro-1,1- hanced sensitivity of the hypotha- stress-induced motor disturbances, neu- difluoroethene, nephrotoxicity, 1248 lamic fl-endorphin system to ethanol ropeptide Y, sigma ligand (rats), 850 Cytochrome P-450 than the alcohol-avoiding DBA/2 w-Conotoxin, -resistant calcium channels, Clara cell cytotoxicity mice, 788 brain slices (rats), 324 naphthalene parenteral administration de Waziers, I., see Flinois, J.-P., 381 Cook, D. J., Housmans, P. R., and Rorie, D. (mice, rats, hamsters), 353 napthalene epoxidation, lung and nasal Dexamethasone, reduction of aspirin-in- K.: Effect of ketamine HCL on nor- duced gastric damage, interleukin 1$, epinephrine disposition in isolated mucosa (mice, hamsters, rats, mon- corticosteroids (rats), 1238 ferret ventricular myocardium, 101 keys), 364 Dexmedetomidine, intrathecal administra- Cook, J. M., see Takada, K., 138 hepatic isoenzymes, inflammation, tolbu- tion, alpha-2 agonists and antago- Cools, W., see Van Wauwe, J., 773 tamide kinetics and dynamics (rab- bits), 780 nists (rats), 764 Corpus, V. M., see Olins, G. M., 1037 Dezocine, discriminative stimulus effects of Corpus cavernosum, penile tissues, func- -mediated activation, aortic guanylyl cy- tional tissues, endothelin-1 (humans, clase, glyceryl trinitrate (rats), 716 morphine, agonist and antagonist ef- fects, mu opioids (rats), 246 rabbits), 795 metabolism of teniposide and etoposide Diamine oxidase, control of contractile re- Cortex (humans), 491 sponse, histamine N-methyltransfer- clonidine binding sites, central actions, Cytochrome P.450 2C11, choline-deficient liver, development of cirrhosis (rats), ase, trachea (guinea pigs), 1268 nitroglycerin (rats), 1187 373 Diazepam NMDA-increased acetylcholine release, Cytochrome P-450 IIE1, sex-/age-/preg- receptor occupancy augmentation by choline (rats), 1122 benzodiazepine nancy-induced changes in metabo- Corticosteroids, reduction of aspirin-in- functional effects of ligands, differing lism, toluene and trichboroethylene, duced gastric damage, interleukin lfl intrinsic efficacies (mice), 1113 liver (rats), 869 (rats), 1238 GABA-stimulated chloride flux (rats), Cytokines, mast cell production, rapamycin Crabbe, J. C., see Phillips, T. J., 525 1106 and FK506, reciprocal antagonists, Craft, N., see Andrawis, N. S., 879 cross-tolerance, tolerance to ethanol, 970 Cremophor EL, emulsifier for intravenous GABA receptor/chloride channel complex (rats), 108 cycbosporin, inhibition ofneurite out- Dafnis, E., Kurtzman, N. A. and Sabatini, locomotor activity, acute sensitivity, growth, neuroblastoma, 803 S.: Effect oflithium and amiboride on FAST and SLOW mice, 525 Croce, K., see Li, T., 959 collecting tubule transport enzymes, Dickerson, M., see Davis, R. E., 1044 Cromakalim, inhibitory effects, BRL 38227, 701 Dihydropyridine airways (guinea pigs, humans), 429 Dailey, J. W., see Yan, Q.-S., 652 inhibition of metabolism by flavonoids, Crowe, V. G., see Jackson, C. V., 546 Dab Forno, G., Pietra, C., Urciuoli, M., Van grapefruit juice, liver microsomes Crumb, W. J., Jr. and Clarkson, C. W.: Amsterdam, F. T. M., Toson, G., (rats, humans), 1195 Characterization of the sodium chan- Gaviraghi, G. and Trist, D.: Evidence metabolism rate of oxodipine (rats, hu- nel blocking properties of the major for two cholecystokinin receptors me- mans), 381 metabolites of cocaine in single car- diating the contraction of the guinea -resistant calcium channels, brain slices diac myocytes, 910 pig isolated ileum longitudinal mus- Cullinan, C. A., see Lodge, N. J., 1153 cle myenteric plexus, 1056 (rats), 324 3,4-Dihydroxymethamphetamine, 2,4,5- Cushing, D. J. and Cohen, M. L.: Compari- Dalton, B. A., see Tagliente, T. M., 755 son of the serotonin receptors that Danhof, M., see Mandema, J. W., 56, 88 trihydroxymethamphetamine and, mediate smooth muscle contraction Danhof, M., see Stijnen, A. M., 81 central serotonergic and dopami- in canine and porcine coronary ar- Daniell, L. C.: Alteration of general anes- nergic systems (rats), 447 tery, 856 thetic potency by agonists and antag- Diltiazem, calcium channel blockers, 3,4- Cyclic AMP onists of the polyamine binding site methylenedioxymethamphetamine coupling of beta-i and -3 adrenergic re- of the N-methyl-D-aspartate recep- (rats), 586 ceptors, agonist exposure, adenylyl tor, 304 2,3-Dimercapto- 1-propane sulfonate, mer- cyclase (rats), 638 Dass, C., see Relling, M. V., 491 curic chloride-induced cytotoxicity, desensitization and down-regulation, 5- Davis, R. E., Callahan, M. J., Dickerson, M. compensatory hypertrophy, proximal HT1H receptor, kidney cell line (opos- and Downs, D. A.: Pharmacologic ac- tubular cells (rats), 819 sums), 271 tivity of CI-977, a selective kappa 2,6-Dimethylclonidine, opposite rank order 1992 Index 1297

of potency, water and solute excre- Dutt, A., Priebe, T. S., Teeter, L. D., Kuo, transport of recombinant CD4, through tion (rats), 1080 M. T. and Nelson, J. A.: Postnatal the blood-brain barrier (rats), 1175 Di Monte, D. A., Wu, E. Y., Delanney, L. development of organic cation trans- Endothelium-derived relaxing factor E., Irwin, I., and Langston, J. W.: port and MDR gene expression in N-substituted arginine compounds, blood Toxicity of 1-methyl-4-phenyl-i,2,3, mouse kidney, 1222 pressure (rats), 875 6-tetrahydropyridine in primary cub- Dynorphin A role for nitric oxide, relaxation induced tures of mouse astrocytes, 44 centrally mediated cardiovascular ac- by acetylcholine, cerebral arteries Discrimination tions, hippocampal function (rats), (cats), 12 agonist-antagonist opioids, two-choice sa- 678 Endotoxemia, septic shock and, regional dif- line-hydromorphone (humans), 62 spinal analgesic action of capsaicin, mor- ferences, vascular reactivity (rab- caffeine (humans), 885 phine-induced antinociception bits), 959 Discriminative stimulus (mice), 643 Endotoxin, -induced activation, cerebral effects of morphine, agonist and antago- Dynorphin A (1-17), spinal morphine-in- catecholamine and serotonin metab- nist effects, mu opioids (rats), 246 duced antinociception, naloxone and olism, interleukin 1 (mice), 964 modulation of effects of cocaine, mu and norbinaltorphimine (mice), 146 Endou, M., see Hattori, Y., 1160 kappa opioids (monkeys), 607 Enkephalin, -metabolizing enzymes, inhi- Disopyramide, block of cardiac sodium Edgar, B., see Miniscalco, A., 1195 bition by RB 101, analgesic responses channel, removal of fast inactivation Edvinsson, L., see Sun, X. Y., 1147 (mice, rats), 181 process, ventricular myocytes (guinea Egros, F., see Flinois, J.-P., 381 Epilepsy, activation of serotonergic neu- see pigs), 1167 Eikenburg, D. C., Sadeghi, H. M., 924 rons, carbamazepine and antiepilep- Diuresis Elayan, I., see Johnson, M., 447 sirine (rats), 652 direct in vitro measure- renal sympathetic nerve activity, cboni- Electrochemistry, Epinephrine dine effects, chronic congestive heart ment, dopamine overflow, interme- alpha adrenoceptor subtypes, emetic ac- failure (rats), 1129 diate pituitary (rats), 403 tion (dogs), 746 water and solute excretion, opposite rank Electroencephalography, modeling of effect chronic treatment, failure to alter pre- order of potency (rats), 1080 site equilibrium kinetics, pharmaco- junctional adrenoceptor modulation, Dobutamine, beneficial effect of MCI-154, dynamics, bacbofen (rats), 88 sympathetic neurotransmission in isehemic contractile failure, myocar- Electrolytes, renal handling, acute effects, mesentery (rats), 924 gentamicin (rats), 38 dial acidosis (dogs), 1087 Epithebial cells, intestinal cell line, mono- of Dopa, responses during stress, sympatho- Electrophysiology, selective modulation layers, transepithelial transport of neural activity, tyrosine hydroxyl- NMDA-induced neuronal activation, oral cephalosporins, 195 ation (rats), 899 CA3 dorsal hippocampus, sigma Ii- Epithelium, retinoid-mimetic effects, liaro- Dopamine gands (rats), 123 zobe (rats, hamsters), 773 AlO region, microinjection of quinpirole, Elgoyhen, A. B., Lorenzo, P. 5., Tellez-I#{241}#{243}n, Eriksson, U. G., see Miniscalco, A., 1195 block of motor activity (rats), 811 M. T. and Adler-Graschinsky, E.: Re- Erythropoietin, developmental differences DA-1 receptor sites, pulmonary artery, laxant effects of fl-carbolines on rat in pharmacokinetics, fetal and nec- endothelial cells (rabbits), 830 aortic rings, 534 natal sheep, 977 differential activation, nicotine and mor- Elovaara, E., see Nakajima, T., 869 Estradiol, potentiation of vasopressor re- Emesis, alpha adrenoceptor subtypes (dogs), phine, brain (rats), 484 sponse, U-46619 lung (rats), 686 3,4dih4thPb#{225}min@, 2,4,5 746 . , Fthnot In4Qt!!toi, §urf@ hindlng nd ntrse efft bupr@norphitw’b efft on st*1f44mini (r), 447 Iulr uptake, gntamiin, tJCPK trtion, smoked oiaine hs, phn g1utsminvokd r#{248}1 pofium d t1lb, 100 ivvtldjn ind hrsn (monky), poti’itbon, trital Iles (rt), 7 cbndorphin inhibbon of n@urons, lhy4roxymb morphine §nd, nalg@M n4 of locomotor 4t’tivity, §vuta nitlvity, nopyrrolidon2, ubstanti nIgr m@t@nkphtin, forbraln (rta), FA8T itnd 8140W mii1 525 Ir) 3$7 106$ nlotin@ itncl, 1fliI1 g@nsIi flnaly, ov@rftow, dir3t In vitro eretion from pituitary, ho1@tystokinin tf)ng itnd bhorttp lnils, 173 nwiurnwtfl1 intermdi pituitary A nd B rptor ntagonita (rta) sensitivity of hypothal*mit indorphin (rota), 406 454 Ybtam, CS7BL/6 mie, 78$ snitlvi1y to thnoI, tkohoIprferring rguttbon of synthls, ut#{248}dministr tolrflnc, role, ‘ nminohntyrk eid r’ flon, mphtami,w (rota), fi47 C57B1-/6 mii@, 78$ ptor/th1orids i4utnnL omp1@x timu14ta4 hynpti ovrflow hroni tndoom, idifid hpti endocytie ve (rst) 10$ hIoprido1 trtm@nt, tritum quetrtion of orgsni 7 *hoycoumt*rin ytochronw P450 m (rota), 74 ions, bitiry @xrtion (rts) 1 taho1im, tanipoids rind toposids of oral rspon@1 NKF In4oth1ial l311, Ioptmin IA1 r@@ptor (htrnmnb), 491 88306, nonta1 6OHDAtelond bita, pu1monry itrtary (rMhits), 830 lthyIktsot!In, Oplold nd nitotnt anal- rsta, rotonin ytam, 1000 niiothelin gsie and hypralgsst loei brain trnaportar, nwthy1phnb4t@ binding 4ut @ffts on S@tditimutad i1um tam (rifl), 707 ita! fourphit s proh (rta), 036 (guin@ pig) 1253 Eti.loprids, seiita rniminitrtlon of srn I)uwn, i:, A, DitviM, 8 1044 ph*phoryktontndwndnt vfleulsr phtamin rultion, dopsmin@ Drn, J,, #{248}Jn@n, A,, 154 ‘ontrtion, rptor agonit (r4t) ynthi (rta) 587 Dropplmn, D, Rntr, W W, 737 5041 4:topoicI tanipoids 4nd, cytochrom P Drug ds1ivry, trnport of rombinnt aympthodrn timu1tion, acute pr 450 mtahoIirn (humans), 491 CD4, through th hboodbrain brrir or rspon yboporin (rats), 994 torphine 4irimintiv iimulu ff@vt (rats), 1175 ndothtln1, funtlonal sffet, pni1 tis- of morphins agonist nd ntagonibt Pufour, A1 e#{248}Filnois, JP, 381 sue (humn, rbblt) 795 mu opioi4s (rL), 246 Dunn, A J,; 1ndotoxin4n4uc4 tlvtion 1n1oth@tium lvin, 14,, Rettbng, M V 491 of irhrl nd sro hreterition of 54-IT reptor, ho tonln m@taho1lm; ComparIson with vin@ coronary rtari, 601 Falwr, ! D?l see Vnn tyk, H W 1 lntartukin1, 964 ragional 4iffrtw@ in ffcts of pti Fsk1m, M Shovh, P, lionsiti, L P, PunwiddI, T V, e Williams, P J, 403 shock vsulr retivIty (rbbita), Jnvk, F Martin, J If, Moru, J, DUP 753, cr4i ngIotanin rptorb 959 L nd l-Iflf1)’ W 1; 14etstionhbp (rbhIta),931 §uQptlbtIlty to Ctt ntsgonit, eere hetw@n bno4i@pin riiptor o Pu NQulh, P,, Prnt1 C,, 780 bral r*ris (dogs) 234 cupny and (untional sffets in k’o 1298 lndx Vol. 261

of four bigands of differing intrinsic Choice between smoked and intra- surface binding and intracellular uptake,

ffIc4Fis; 1113 #{149} venous cqin, 4141 _1 cell, 1299 F’f:qm, 4.,Scbo#{231}h,. n#{231}i %%. Fotin, . %V. n4 ‘i#{231}lmau,4. W.: Th arjr, J.G., see Gilwpr, D. 4, 1181 .: 8i4tipnslip cariiova#{231}ular ap4 1i)1ictiY ff#{231}s erbar4t, G. 4., s#{231}eWilliam, p. 403

pins cptQ; OCUJflT I!4 pn- Qt_iptryenqua ppcp an4 moqline qeula! C., e#{231}oupg, 4 ., 2441 tiation of y-minqbut’ric cid-stim- conlinatiqns in lurnan, 623 qiQulakis, fJ., #{231}ete Waele, ,I.-., 74141 I1tfI cbbo;i4 flu; in vitro of fopr Folt;, II. L., see Johpspn, 4., 447 ibb, 1. see Johnsqn, k’!447, $6 pgR4 of ditfrirg intrinSic ftica- obrin, -dorpin an#{231}lo:pki, an- 1ilmor, D. 4, Ga!, ‘I, ferbar, J. f. a4 algsia, of’ Fis, 1106 r1ea S.: 4ge and gea4p#{231}iPflua9ce FFtor VIIe, relas, inhibition, vasQpr- (rats), 1028 the terepe!pctiye phawacp*atics sin utgpnt (mppr), 4412 Forman, 4, fec }Ioluiquit, 795 qt piopranolol, 1181 q4n, 4. . nI l1:, .: orsoljn, 4enstzajpn an4 4qw-rgu- qlilepciami4e factQl: rduc spin1 cprd bood laton, 5-HuB i4i’ cll antihypertpsiye ef(ts of -27152 (rats, ar4 cau ihsrioal d#{216}icits4ftr line (oposs4ip), 271 dogs), 730 iptqtbcl adminitration in rats Forte, J. f3., see Rentra, W. 737 inhilitn of 4T?-sensiti !:p4gh spciIc ecptor m#{231}h- poster, ,. E., . 8. a’14 j4. ca4iac muscle (g*inq pig), 540 111am, t$4 .: 4p ipvestigtiQn of t aFqtaf- Gloznenla flltratioz rata, gl#{231}ip-ip4u#{231}4 ;l1t, k1. s Thqrna, 13., 875 f#{231}tof gntamiin Qn the renal ban4- hrparfi1tratipn, angiptensip-rnip ;b,4.V. an4 we!! . W.: t4io1 lmg f in th rat, 341 ‘stm inhibition (rata, 941 Rpt!tit tt1 yaPpressQr pOflSp FQl4cflie-Za!qSi, M. ., eekobie, ., 1411 floinjd, ‘I., see Yezina, P., 484 #{243}#{231}t isq1ad pid rat lpig to ‘ourphit, lectve fo nt1iiphn- qutan2ate

tI thrQIflkpafl miic U-q619, . date bir4ipg 4ppaine trans- -evpd dqpanine relase, ?QtauP 4e- 6841 portr (rata), 9341 ppIa;atipn, striatab (at), 72 acetylcbqjp ;cll, f. f., M4ray, M. 373 roy, R. 4., rls, 4. . aii Wii1arspn, W NMP4-ipcreased aa! P.: Carp;i;atipn qf 5-l’4coi- ug4t1pn by cbpira, tq1;1a Lron, adpyi1!l crclaa an#{231}ibeta dre- trrpt4u21R? ;cptq#{231}sin bpsrpe coro- an cort; (rta), 1 1? no#{231}ptors,prinatal ihngs (rt-s), nary artries, 41ffl lptathione 4133 #{149} Fraru, L. 1., see qwr;:, J. F. 72 c’te CQfljugas, 2-bromp-2-blpo-1, cpuping of 1eta-1 and -3 drnergip r- francis, P. #{149}?aria1P, 4. 1., j. i-diflipoethan, p;ptq;icjr, 9tq adenriyl crlase, agoni ;- C. 4, M*44e, a ii., $tatin, 124$ pQ (rats)! 4138 p. C. §9VaR? 4.:5- mercuric chloride-inducd ctgtqcitr, pg, 9. ., S., Thorn, . an4 iy4rp;ytrrpta1n1A hut pqt 5- cqnpetPi:y Rarti0pr p;;a! Ipr, T of #{231}opidiipon bydoYttafie2 90 ar fl tubular cells (rats), 819 qiTlunc1, LtromachaniFal 1ta of p R! sympathtc nrv 8ctivitT, na- riched on p’ai4a n- t4p1:i #{149}ana in #{231}hrpnic rQns astrq4’ intatla vpl- lialiw, atia! a4 vnt4cia m2a cppgtye hart failu; rata, 1129 nsin, 1273 (cats), 1153

. ??RP’, F. ., Milicc, I., 4istrr, I, )4cg, Frank, fl., #{231} P. 5441 Glyprrl #{149}triiutrata, hepatic c’tpchcpa nA 1qpn, ,.: Eff#{231}tof ijimqto, ,. M. ee 4;ta, . S., 4143 450-me4ated activation, aortic clptiazem on t;l presurp an4 ujiwoto, J. M. ee olwas, W P.’ 1441 uaRylT cyc1ae (rats), 7141 renal fun#{231}tiorin pprnotnsiv an4 uuhara, ., ec W, 899 Glycina 1wpct;!siYe 470 ‘uuna;i, 4., e#{231}aajaa, T- 7Q -in4ucc! g1oerula hype;filtcatiQn, an-

., giotnin-rpin s’stem iphbitiop ?flrjC, J. W., s Qlivto, . j.,885 ‘ukut, T. see SIlinaru, 49 ip4lay, .; nbiktion of 4T-psitis’ Fuller, . W., gong, L., 1909 (rats), 941 happels in rdiF muscl br the ‘ung, }3.-L., eeT;e#{225}g,T.3, 4192 inhibition of substaritia nga 4ppamin s4!phPnylur 4mg gliknclrni#{231}, ‘ura-2, mrosin neurqp, 1-hrq;’-3-#{225}uinppro1i- 540 ent contFtiqn, i4uptjon r p1qr)ql don-2 (rats), 387 M P.’ Bagga, . B. and 4n4ers, estee, vascular rpopt1 muIe (ata), NMP* reeptor ant-gQn4ta, #{231}athon M. W.: p1;otq;iity of th gluta- 497 wQno;i4-mci14C#{231}1 brain dan,ge tbione anI cytizW conjugat of 2- (mice), 349 Gal, J., see Qilmo, P. 4., 1181 qold, L. ., alcbonado, R., §419 Gallamipe, phaic i:epoiss to carbachol, 1248 qp14nbrg, }. J., sg aris, fl. 1l., 131 inhibition b’ nifdipin, trqchea ighmn, M. W., see ‘qltin, R. W., 4123, qqldman, . jr., 8., 341 (guinea pigs), 755 841 qp1c1stip, p. $., f? IYtnaaT, ., 899 f3allblqddr, 4byini agonist and antag- 195Q41, prnycjp an4, IUSt cell cytoine qopg, L., 1qtrzewa, 1. ., uf1, . W. onSts (guiq pg 191 p;:p4uction, rcprcal ntagpnists, aiic! . W.: 970 Galloway, ., see yler, . ., 5417 oi e #{176}a!eppn tq S 38393 in Elyonoils, grapf#{231}uit juice, inhibition of qalprn, w.R., see Miller, L. 1., ?8 naqnatal 41-P!fl4-isipned ata dibrdrppyridine in#{216}.bolism, liver Ganglionctomr, moc(als q1 paripbeal srm- me4iatd thrQugh a erQtoRIp system, mic06Qme (rats, human, 1195 pathetic autQgu1atipn, of nu- 1900

ronal bitmiae (rats), a43 Gopdwin, . Linter, ., 4412 ?IiIoiS, ihbin, 4., grQ, ., Dufour, T. #{231}e L. s#{231}eqst#{231},#{182}1.., 38 4., Wazirs, 1., as-fhambelin, Garland, 1:1.0., qoqssns, J., ee Van Wauwe, ,., 773 .: l3arras, see Phritnp, 19941 . ‘! ‘1W’ . MtIlpI 4, W, Granneman, ,. G. ec hudtry, 4, §33 rats pfoijpip in rats and humn: Garri, . is.,see Wideinanp, . 4., 574 Qranneman, q.: ffects of gqist pp- JQmparison of in viva and in vitro qavirghi, ., Pal 2prnq, q., iOS sLce op the poup1ig oui#{216}a1an4 beta3 data, 381 elboin, . V., s#{231}ek,aiajima, T. 41419 drengi cepeptqrs to lylyl cy- lpr4, D. 4., ee Hrrjs, P. *., 131 tend, age an4, parrnaFo- clae iaisoe4 a4pqrt, 41341 la;zin, pimQciIp1n and, dcra in ineUcs, prppqnool (humans), 1181 grapefruit ju#{231},41apnqi, inbition p1 tryptoplan 1rdro;rlase activitr, qene dihy#{248}rqpyridneI1wtal:pisp1, live; mthamhtarnin (rats), 5841 bQng- and sbort-leep mice, respop to rniFrqsprnes (rats, 1uqis), 1195

olates, PitrQUS o;id ;posure of cultured nicotine an4 ethanol, 173 Greenhlatt, p. ,, Miller, . ., 2841 cells, homocystain mthylation, MDR, postnatal dre1oprnent of orgpi#{231} quanybyl #{231}ycle, aorti#{231},hepatic cyto- 10941 cation tranport, t9ne1’ (mica), 1222 chrome P450-mediate4 activation,

1lpir, J. ., see L.odgs, N. J., 1153 Gentamicin glyryl trinitrate (rats), 7141 pttn, R. %4.and Fispbman, k4 W.: Self- acuta effect, renal handling of electro- Gue, M., unien, ‘I. L., Pal io, . an#{231}i adginistration ofcocnine by humans: bytes (rats), 38 ueno, L.: t’europeptice and igma 1992 Index 1299

ligand (JO 1784) suppress stress-in- prostacyclin production (rabbits), pyramidal cells, dual effects of pyrazole, duced colonic motor disturbances in 660 NMDA receptors (rats), 331 rats through sigma and chobecysto- angiotensin receptors, DUP 753 and PD region-specific regulation, clozapine 1, ex- kinin receptors, 850 121981 (rabbits), 931 trastriatal doparnine D2 receptors Guimar#{227}es,C. L. and Rae, G. A.: Dual ef- atrial and ventricular muscle, electrome- (rats), 1282 fects of endothelins -1, -2 and -3 on chanical effects, celikalim (cats), Hirudin, comparative antithrombotic ef- guinea pig field-stimulated ileum: 1153 fects, femoral vein platelet-rich mu- Possible mediation by two receptors cardiovascular and subjective effects, in- ral thrombosis model (hamster), 895 coupled to pertussis toxin-insensitive travenous cocaine, morphine combi- Hisatome, H., see Koumi, 5.-I., 1167 mechanisms, 1253 nations (humans), 623 Histamine Gwiazdon, C. C., see Phillips, T. J., 525 centrally mediated cardiovascular ac- neuronal, two models, peripheral sympa- GYKI-14766, see D-Methyl-phenylalanyl- tions, dynorphin A(1-8), hippocam- thetic autoregulation (rats), 943 prolyl-arginal pal function (rats), 678 punishment of schedule-controlled be- chronic congestive heart failure, clonidine havior, fl-carboline injections (mon- H,K-ATPase, inhibitor AHR-9294, gastric effects, renal sympathetic nerve ac- keys), 138 HC1 secretion (rats, dogs), 737 tivity (rats), 1129 regional differences in effects of septic Haefely, W. E., see Facklam, M., 1106, 1113 disopyramide block of sodium current, re- shock, vascular reactivity (rabbits), Hall, S. E., see Harris, D. N., 131 moval of fast inactivation process, 959 Haloperidol ventricular myocytes (guinea pigs), Histamine N-rnethyltransferase, control of chronic treatment, stimulated synaptic 1167 contractile response to histamine, overflow of dopamine, striatqm trachea (guinea pigs), 1268 (rats), 574 inhibition of ATP-sensitive K channels, glibenclamide (guinea pigs), 540 Hitzemann, B., see Qian, Y., 341 D1 and D2 dopamine receptor distribution, Hitzemann, R., see Qian, Y., 341 neuroleptic nonresponsive and re- ontogeny of beta adrenergic receptors, thyroid hormone, adenybate cyclase HIV, transport of recombinant CD4, sponsive lines (mice), 341 through the blood-brain barrier modulation of NMDA-induced neuronal (rats), 951 (rats), 1175 activation, CA3 dorsal hippocampus, SC-51316 pharmacology (rats), 1037 Holmes, B. B. and Fujimoto, J. M.: Nalox- sigma ligands (rats), 123 Heart rate, baroreflex changes, serotonergic one and norbinaltorphimine admin- region-specific regulation, cbozapine 1, ex- or catecholaminergic lesions, nucleus istered intracerebroventricularly an- trastriatab dopamine D2 receptors tractus solitarius (rats), 225 tagonize spinal morphine-induced (rats), 1282 Hedner, T., see Feng, Q. P., 1129 antinociception in mice through the Halt, P., see Faden, A. I., 1064 Hedner, T., see Sun, X. Y., 1147 antianalgesic action of spinal dynor- Hamann, S. R. and Martin, W. R.: Opioid Heijligers-Feijen, C. D., see Mandema, J. phin A (1-17), 146 and nicotinic analgesic and hyperal- W.,88 Holmes, C., see Kvetnansky, R., 899 gesic loci in the rat brain stem, 707 Heishman, S. J., see Azorlosa, J. L., 114 Holmquist, F., Kirkeby, H. J., Larsson, B., Han, W.-C., see Harris, D. N., 131 Hemostasis, inhibition of clotting factor re- Forman, A., Alm, P. and Andersson, Hanson, G. R., see Johnson, M., 447, 586 lease, vasopressin antagonist (mon- K.-E.: Functional effects, binding Hare, M. F. and Atchison, W. D.: Compar- keys), 462 sites and immunolocalization of en- ative action of methylmercury and Henrion, D., Laher, I., Laporte, R. and Be- dothelin-1 in isolated penile tissues divalent inorganic mercury on nerve van, J. A.: Angiotensin II amplifies from man and rabbit, 795 terminal and intraterminal mito- arterial contractile response to nor- Homeostasis chondrial membrane potentials, 166 epinephrine without increasing Ca models of peripheral sympathetic auto- Harpur, E. S., see Foster, J. E., 38 influx: Role of protein kinase C, 835 regulation, role of neuronal hista- Harris, D. N., Micheb, I. M., Goldenberg, H. Heparin mine (rats), 943 J., Hartl, K. S., Allen, G. T., Stein- antithrombotic activity, D-methyl-phen- sulfate and 3’-phosphoadenosine 5’-phos- bacher, T. E., Schumacher, W. A., ylabanyl-prolyl-arginal (dogs), 546 phosulfate, acetaminophen adminis- Han, W.-C., Hall, S. E., Floyd, D. M. comparative antithrombotic effects, fem- and Ogletree, M. L.: Pharmacological tration (rats), 1015 oral vein platelet-rich mural throm- Homocysteine, remethylation, nitrous oxide characterization of potent, long-act- bosis model (hamster), 895 exposure, folates, 1096 ing thromboxane receptor antago- Heroin Honda, K., see Miyata, K., 297 nists, SQ 33,261 and SQ 33,552, 131 alfentanil- and cocaine-reinforced re- G. Hori, M., Sato, K., Sakata, K., Ozaki, H., Harris, C. and Williams, J. T.: Sensiti- sponding, effects of buprenorphine zation of locus ceruleus neurons dur- Takano-Ohmuro, H., Tsuchiya, T., (monkeys), 311 Sugi, H., Kato, I. and Karaki, H.: ing withdrawal from chronic stimu- intravenous cocaine and morphine corn- lants and antidepressants, 476 Receptor agonists induce myosin binations, cardiovascular and subjec- Hartl, K. S., see Harris, D. N., 131 phosphorylation-dependent and tive effects (humans), 623 Haslanger, M. F., see Kanazawa, M., 1231 phosphorybation-independent con- 12-HETE, novel nonredox inhibitors of 5- Hatfield, S. M., Mynderse, J. S. and Roehm, tractions in vascular smooth muscle, lipoxygenase, boswellic acids, 1143 N. W.: Rapamycin and FK506 differ- 506 Hexamethonium, phasic responses to car- entially inhibit mast cell cytokine Hori, M., see Sato, K., 497 bachol, inhibition by nifedipine, tra- production and cytokine-induced Hori, R., Okuda, M., Ohishi, V., Yasuhara, chea (guinea pigs), 755 proliferation and act as reciprocal an- M. and Takano, M.: Surface binding Higgins, S. T., see Oliveto, A. H., 885 tagonists, 970 and intracellular uptake of gentami- Hikasa, Y., Ogasawara, S. and Takase, K.: W-ATPase, sequestration of organic cat- cm in the cultured kidney epithebial Alpha adrenoceptor subtypes in- ions, acidified hepatic endocytic yes- cell line (LLC-PK,), 1200 ides, bibiary excretion (rats), 1 volved in the emetic action in dogs, Housmans, P. R., see Cook, D. J., 101 Hattori, Y., Endou, M. and Kanno, M.: In- 746 Huang, H.-C., see Olins, G. M., 1037 hibition by 5-hydroxytryptamine of Hill, H. F., see Jang, J., 592 Huffman, W. F., see Kinter, L. B., 462 the beta adrenoceptor-mediated pos- Hippocampus Hughes, J. R., see Oliveto, A. H., 885 itive inotropic responses to catechol- activation of serotonergic neurons, Hyde, J. F., see Liu, Y., 560 amines in rabbit papillary muscles: carbamazepine and antiepilepsirine Hydrornorphone Direct interaction with beta adre- (rats), 652 acute effects, rnethadone-rnaintained vol- noceptors, 1160 CA3 dorsal, NMDA-induced neuronal ac- unteers, 985 Hayakawa, H., see Koumi, 5.-I., 1167 tivation, sigma ligands (rats), 123 -saline discrimination, agonist-antagonist Heart centrally mediated cardiovascular ac- opioids (humans), 62 adenosine receptor-mediated alterations, tions, dynorphin A(1-8) (rats), 678 1-Hydroxy-3-aminopyrrolidone-2, inhibi- 1300 Index Vol. 261

tion of substantia nigra dopamine thelial transport of oral cephalospo- thamphetamine, two metabolites of neurons, non-NMDA receptor-me- rims, 195 3,4-methylenedioxymethamphetam- diated mechanism (rats), 387 jejunal mucosa me, on central serotonergic and do- 2-Hydroxypropyl--cyclodextrin, use as an neurokinin receptors, ion transport paminergic systems, 447 intrathecal drug vehicle, opioids (pigs), 1213 Johnson, M., Mitros, K., Stone, D. M., Zobr- (rats), 592 sodium and bicarbonate secretion, sub- ist, R., Hanson, G. R. and Gibb, J. Hyperalgesia, opioid and nicotinic analgesic stance P (pigs), 1206 W.: Effect of flunarizine and nimo- and hyperalgesic loci, brain stem metabolism rate of oxodipine (rats, hu- dipine on the decrease in tryptophan (rats), 707 mans), 381 hydroxylase activity induced by Hyperpnea, neonatal breathing, in utero co- Inui, K.-I., Yamamoto, M. and Saito, H.: methamphetamine and 3,4-methyle- caine exposure (guinea pigs), 420 Transepithelial transport of oral nedioxymethamphetamine, 586 Hypertension cephalosporins by monolayers of in- Johnston, C. I., see Kanazawa, M., 1231 antihypertensive effects of Y-27152 (rats, testinal epithelial cell line Caco-2: Junien, J. L., see Gue, M., 850 dogs), 730 Specific transport systems in apical Jutras, L., see Parent, C., 780 centrally mediated cardiovascular ac- and basolateral membranes, 195 tions, dynorphin A(1-8) (rats), 678 Ion transport, neurokinin receptors, jejunal Kalant, H., see Mihic, S. J., 108 clentiazem effect, arterial pressure, renal mucosa (pigs), 1213 Kalivas, P. W., see Steketee, J. D., 811 function (rats), 470 Irwin, I., see Di Monte, D. A., 44 Kalsner, S.: Activation of a relaxation cas- pharmacodynamics and pharmacoki- Ishimaru, H., Katoh, A., Suzuki, H., Fukuta, cade in isolated coronary arteries by netics, morphine, spontaneously hy- T., Kameyama, T. and Nabeshima, brief electrical pulses, 209 pertensive and normotensive rats, T.: Effects of N-methyl-D-aspartate Kamato, T., see Miyata, K., 297 290 receptor antagonists on carbon mon- Kameyama, T., see Ishimaru, H., 349 time course of morphine distribution, oxide-induced brain damage in mice, Kanazawa, M., Casley, D. J., Sybertz, E. J., brain and spinal cord, intravenous 349 Hasbanger, M. F. and Johnston, C. I.: injection (rats), 1008 Isoproterenol, inhibition of positive mo- Localization and characterization of Hyperthermia, pharmacodynamics and tropic responses, serotonin and cate- neutral metalloendopeptidase (EC pharmacokinetics, morphine, spon- cholamines, papillary muscle (rab- 3.4.24.11), the degradative enzyme taneously hypertensive and normo- bits), 1160 for atrial natriuretic peptide, in rat tensive rats, 290 Ito, H., see Miyata, K., 297 kidney using a radioiodinated neutral Hypothalamus, 9-endorphin system, sensi- Itoh, H., Alper, R H. and Bu#{241}ag,R. D.: metalloendopeptidase inhibitor, 1231 tivity to ethanol, alcohol-preferring Baroreflex changes produced by se- Kanno, M., see Hattori, Y., 1160 C57BL/6 mice, 788 rotonergic or catecholaminergic be- Karaki, H., see Hori, H., 506 Hypothyroidism, propylthiouracil-induced sions in the rat nucleus tractus soli- Karaki, H., see Sato, K., 497 perinatal, ontogeny of beta adrener- tarius, 225 Katakura, Y., see Nakajima, T., 869 gic receptors, heart and kidney (rats), Kato, I., see Hori, H., 506 951 Jackson, C. V., Crowe, V. G., Frank, J. D., Katoh, A., see Ishimaru, H., 349 Wilson, H. C., Coffman, W. J., Ut- Katoh, A., see Nakajima, T., 730 terback, B. G., Ja1ubowksi, J. . and tatp;i, K, see oumi, 8.-I., 11417 aetylcboline rlasing properties, ben- Smith, G. F.: harmacbogical asess- atsuyasia, s#{231}eyeta, , 297

zimidazobone dejivatives (guinea merit of the antithromtqtic activity atz, J. L., see Rican;te, C. ., 6141

pigs),412 of the peptide thrombin inhibitor, D- Iatz, J. ., see akada, ., 138 fie1i-stunulated, dual effects, endothehns rnethyl-pbenrlabanyl-p;oly-qrgina1 5412 cells, epreion, a4enosiue diphos- (guinea pigs), 1253 (GYKI-14766), in canine model of phate purinergic receptprs, 580 lpgitu#{231}iina1 #{252}scle myenteric pleus, coronary arte;y thrombosis, 5.41 Ketamine, discriminative stimulus effects of pe1atiQn of cpntactipn, chQlecys- Jakubowski, J. ., see Jaccon, C. V., 5441 morphine, agqnit and ntagqnit ef- tokinin receptors (guina pigs), 1056 Jang, J., Yaksh, T. L. an4 1iil, Ii. F.: Use fect$, mu opipid (rats), 2441 ImrnunobistQcbemisry, ftinctipnal effects of 2-hydxoypropy1-l1-cyc1odetrin as Ketamine UC1, np;epiepb;ine ctisppsitiQn, of en4pthelin-1, pnile tissues (hu- an intrathecal drug vehicle with ventricular myocardium (ferrets) mans, rabbits), 795 opiolds, 592 101 Irnura, Y., $tassep, J.-M. and Collen, P.: Janowsky, A. Neve, K. 4Ap, inzie, J. M., Kidney Comparative antitbrombotic effects Taylor, B., de Paulis, T. and Bellnap, arterial pressure and renal function, clan- of bpa;in, recombinant biru#{231}iinan4 J. K.: E;t;astriatal dppamine D2 re- tiazem effect norinotepsive apd hy rgatrpban in a banter femoral vein ceptors: Distribution, pharma#{231}ologi- pertensive rats, 470 platelet-rich mural thrombpsis cal characterization and region-spe- collcting tubule transport enzymes, lith- model, 895 cific regulatipn by clpzqpine, 1282 ium anc amilp;ide (rats), 701 Infant, fetal and neonatal sheep, erythro- Jansen, A., Drazen, J., Qsborpe, J. 4., desensitization and don-reguIation, 5- poietin pharmacokinetics, 977 Brown, R., Loscalzo, J. and Stamler, HT1B receptor (pppssums), 271 1nfaxnrnation, bepatic cytpcbrpme -45O J. S.: The ;ela;ant properties in glycine-induced hyperfiltration, angiotn- isoenzymes, tojbutam4e kinetics and guinea pig airways of S-nit;osothiols, sin-renin system inbiitjpn (rats), 941 drnarnics (abbits), 780 154 handling of lectrolyts, acute effects,

gepito, A. tL, ee %4apg, ‘. ., 4178 Janssen, P. 4. J., see Van Wauwe, J., 773 gentamicin (rats), 38 ppsitol, lipid signaling system, mechanism Jejunum, mucosa, sodium and bicarbonate interference with qrgnj#{231}patiqn trans- of vasodilting action, berberine secretion, substance (pigs), 1206 port, nicptipe, paswa of haIitual tp- (guinea pigs), 318 Jenck, F., see Facklam, M, 1113 bacco smokers (rats), 21 d-tnyo-Inositpl-1,2,6-trisphosphate, neuro- JO-1784 localization and cbaractenzation, neutral peptide Y-induced potentiation, var- modulation of kiP-induced neuronal metallpenoppt#{231}1ase (rats), 1231 bus vasocpnstrictor agents (rats), activation, 1143 dorsal hippocampus, MPCK cell monolayers, nonionic diffu- 1147 sigma ligands (rats), 123 sion, salicylic aci4, 1071 thterleukin 1, endptQip-induce4 activation, neuropeptide V and, suppression, stress- multidnig transp9ter, colchicipe secre- cerebral catecholamine and serotonin induced colonic motor disturbances tion, effect of CycIQspo;me (rat), 50 metabolism (mice), 9414 (rats), 850 ontogeny of b#{231}tga4renerg receptors, Interleukin 1i., recton of aspirin-induced Jobe, P. C., sec Van, .-S., 652 thyroid horpiqne adenylate cyclase gastric damage, corticosteroids (rats), Johnson, M., Elayan, I., Hanson, G. R., (rats), 951 1238 Foltz, R. L., Gibe, J. W. and Lim, H. postnatal 4evelopment of organic cation Intestine K.: Effects of 3,4-dibydro;ymetbam- transport, uirn gene expression epithelial cell line, monolayers, transepi- phetamine and 2,4,5-trihydroxyme- (mice), 1222 1992 Index 1301

prejunctional apha-2 adrenergic recep- Lemoine, H. and Overlack, C.: Highly po- idine metabolism, flavonoids found tore, adrenergic transmitter release tent beta-2 sympathomimetics con- in grapefruit juice (rats, humans), (rats), 1050 vert to less potent partial agonists as 1195 pressor and vasoconstrictor effects, NG. relaxants of guinea pig tracheae max- LLC-PK cells nitro-L-arginine, sympathetic nerv- imally contracted by carbachol. Corn- surface binding and intracellular uptake, ous system (rats), 240 parison of relaxation with receptor gentamicin, 1200 proximal tubular cells, mercuric chloride- binding and adenybate cyclase stim- transport of salicylic acid through mono- induced cytotoxicity, compensatory ulation, 258 layers, 518 hypertrophy (rats), 819 Leukotriene, novel nonredox inhibitors of Locomotor activity, effects of abused drugs, regional differences in effects of septic 5-lipoxygenase, boswellic acids, 1143 acute sensitivity, FAST and SLOW shock, vascular reactivity (rabbits), Levorphanol, modulation of discriminative mice, 525 959 stimulus effects, cocaine, mu and Locus ceruleus renal sympathetic nerve activity, cloni- kappa opioids (monkeys), 607 neurons, sensitization during withdrawal, dine effects, chronic congestive heart Li, P., see Smyth, D. D., 1080 chronic stimulants and antidepres- failure (rats), 1129 Li, T., Croce, K. and Winquist, R. J.: Re- sants (rats), 476 transport of salicylic acid through mono- gional differences in the effects of role of different brain structures, mor- layers, 518 septic shock on vascular reactivity in phine withdrawal syndrome (rats), Kim, H. J., Rozman, P., Madhu, C. and the rabbit, 959 669 Klaassen, C. D.: Homeostasis of sub- Liaci, J., see Speeg, K. V., 50 Lodge, N. J., Colatsky, T. J., Cullinan, C. fate and 3’ -phosphoadenosine 5’- Liarozole, retinoid-mimetic effects (rats, A. and Follmer, C. H.: Electrome- phosphosulfate in rats after aceta- hamsters), 773 chanical effects ofthe putative potas- minophen administration, 1015 Lidocaine, opioid and nicotinic analgesic sium channel activator celikalim Kinter, L. B., McConnell, I., Goodwin, B. and hyperalgesic boci, brain stem (WAY-120,491) on feline atrial and T., Campbell, S., Huffman, W. F., (rats), 707 ventricular muscle, 1153 Arthus, M.-F., Lonergan, M. and Liebson, I. A., see Preston, K. L., 62 Lofentanil, use of 2-hydroxypropyl--cy- Bichet, D. G.: Vasopressin antagonist Liebson, I. A., see Strain, E. C., 985 clodextrin, intrathecal drug vehicle inhibition ofcbotting factor release in Ligands (rats), 592 the rhesus monkey (Macaca mulatta), benzodiazepine receptor occupancy, Lonergan, M., see Kinter, L. B., 462 462 GABA-stimulated chloride flux Long, J. P., see Ma, S., 1187 Kinzie, J. M., see Janowsky, A., 1282 (rats), 1106 Lorazepam Kirkeby, H. J., see Holmquist, F., 795 differing intrinsic efficacies, functional attenuation of chronic effects, PK11195, Kishi, R., see Nakajima, T., 869 effects, benzodiazepine receptor oc- chronic benzodiazepine administra- Kitada, Y., see Abe, Y., 1087 cupancy (mice), 1113 tion (mice), 285 Klaasen, C. D., see Kim, H. J., 1015 sigma tolerance and withdrawal, GABAA recep- Koob, G. F., see Maldonado, R., 669 neuropeptide Y, stress-induced colonic tor-operated chloride channels Kopin, I. J., see Kvetnansky, R., 899 motor disturbances (rats), 850 (mice), 395 Kostrzewa, R. M., see Gong, L., 1000 NMDA-induced neuronal activation, Lorenzo, P. 5., see Elgoyhen, A. B., 534 Koumi, S.-I., Sato, R., Hisatome, I., Hay- CA3 dorsal hippocampus (rats), 123 Loscalzo, J., see Jansen, A., 154 akawa, H., Okumura, H. and Katori, Lotti, V. J., see Scott, A. L., 931 Lim, H. K., see Johnson, M., 447 R.: Disopyramide block of cardiac so- Lundahl, J., see Miniscalco, A., 1195 Lin, L., see Pucci, M. L., 240 dium current after removal of the fast Lung Lipe, G. W., see Bowyer, J. F., 72 inactivation process in guinea pig Clara cell cytotoxicity, cytochrorne P-450 Lipids, mechanism of vasodilating action, ventricular myocytes, 1167 berberine (guinea pigs), 318 activity, naphthalene (mice, rats, Kuck, M. T., see Mandema, J. W., 56 hamsters), 353 5-Lipoxygenase, novel nonredox inhibitors, Kuo, M. T., see Dutt, A., 1222 potentiation of vasopressor response, es- boswellic acids, 1143 Kura, H., Yoshino, M. and Yabu, H.: Block- tradiol, U-46619 (rats), 686 Lithium, amiloride and, collecting tubule ing action of terodiline on calcium LY215840, block of vascular and platelet 5- transport enzymes (rats), 701 channels in single smooth muscle HT2 receptors, delay of occlusion, Liu, J.-F., see Mihic, S. J., 108 cells of the guinea pig urinary blad- model of thrombosis (rabbits), 202 Liu, Y., Hyde, J. F. and Vore, M.: Prolactin der, 724 regulates maternal bile secretory Kurtzman, N. A., see Dafnis, E., 701 Ma, S., Long, J. P. and Bhatnagar, R. K.: function post partum, 560 Kvetnansky, R., Armando, I., Weise, V. K., Further studies on central actions of Liver Holmes, C., Fukuhara, K., Deka-Sta- nitroglycerin and lack of evidence for acidified hepatic endocytic vesicles, se- rosta, A., Kopin, I. J. and Goldstein, nitroglycerin interacting on [3H] questration oforganic cations, bibiary D. S.: Plasma dopa responses during cbonidine binding sites in cortex excretion (rats), 1 stress: Dependence on sympatho- membranes, 1187 choline-deficient, cytochrome P450 2C11, neural activity and tyrosine hydrox- Mack, T., see Safayhi, H., 1143 development of cirrhosis (rats), 373 ylation, 899 Madhu, C., see Kim, H. J., 1015 cytochrome P-450 isoenzymes, inflam- Maeyama, K., see Ohrui, T., 1268 Lactation, pharmacokinetics of cimetidine mation, tobbutamide kinetics and dy- Maggi, C. A., see Patacchini, R., 191 (rats, rabbits), 918 namics (rabbits), 780 Magnesium, renal handling of electrolytes, Laher, I.: see Henrion, D., 835 cytochrome P-450-mediated activation, acute effects, gentamicin (rats), 38 Lahners, K. N., see Chaudhry, A., 633 aortic guanylyb cyclase, glyceryb trim- Mahaffey, J. M., see Azorlosa, J. L., 114 Langston, J. W., see Di Monte, D. A., 44 itrate (rats), 716 Maldonado, A. L., see Speeg, K. V., 50 Laporte, R.: see Henrion, D., 835 impaired biliary excretion, acetamino- Maldonado, R., Stinus, L., Gold, L. H. and Larsen, A. K., see Bhargava, H. N., 1008 phen glucuronide, phenobarbital Koob, G. F.: Role of different brain Larson, A. A., see Parsons, A. M., 1213 (rats), 1022 structures in the expression of the Larson, C., see Carroll, M. E., 26 metabolism rate of oxodipine (rats, hu- physical morphine withdrawal syn- Larsson, B., see Holmquist, F., 795 mans), 381 drome, 669 Lash, L. H. and Zalups, R. K.: Mercuric stereoselective pharmacokinetics, pro- Malik, K. U., see Cano, C., 660 chloride-induced cytotoxicity and pranobol, age and gender influences Malik, K. U., see Schwartz, D. D., 1050 compensatory hypertrophy in rat (humans), 1181 Mandema, J. W., Heijligers-Feijen, C. D., kidney proximal tubular cells, 819 sulfate and 3’-phosphoadenosine 5’-phos- Tukker, E., De Boer, A. G. and Dan- Lavigne, G. J., see Miblington, W. R., 454 phosulfate, homeostasis, acetamino- hof, M.: Modeling of the effect site Lehmann-Romeyn, H., see Shepard, P. D., phen administration (rats), 1015 equilibration kinetics and pharma- 387 Liver microsomes, inhibition of dihydropyr- codynamics of racemic baclofen and 1302 Index Vol. 261

its enantiomers using quantitative Methamphetamine, decrease in tryptophan Mitochondria EEG effect measures, 88 hydroxylase activity, flunarizine and membrane potentials, comparative ac- Mandema, J. W., Kuck, M. T. and Danhof, nimodipine effects (rats), 586 tion, methylmercury and divalent in- M.: In vivo modeling of the pharma- Methanol, locomotor activity, acute sensi- organic mercury, 166 codynamic interaction between ben- tivity, FAST and SLOW mice, 525 toxicity of 1-methyl-4-phenyl-1,2,3,6-tet- zodiazepines which differ in intrinsic Methionine synthase, nitrous oxide expo- rahydropyridine, primary cultures, efficacy, 56 sure of cultured cells, homocysteine astrocytes (mice), 44 Manning, R. E., see Ohms, G. M., 1037 remethylation, folates, 1096 Mitros, K., see Johnson, M., 586 Manzo, L., see Rizzi, C. A., 412 Methoxamine, alpha adrenoceptor subtypes, Miyata, K., Kamato, T., Nishida, A., Ito, Marijuana, smoking, varying tetrahydro- emetic action (dogs), 746 H., Yuki, H., Yamano, M., Tsutsumi, cannabinol content, number of puffs N-Methyl-D-aspartate R., Katsuyama, Y. and Honda, K.: (humans), 114 increased acetylcholine release, striatum Role of the serotonin3 receptor in Mann, J., see Alonso, M. J., 12 and cortex, augmentation by choline stress-induced defecation, 297 Marteblo, A. L., see Ricaurte, G. A., 616 (rats), 1122 Modi, N. B., see Widness, J. A., 977 Martello, M. B., see Ricaurte, G. A., 616 receptor antagonists, carbon monoxide- Monnet, F. P., Debonnel, G. and de Mon- Martin, J. R., see Facklam, M., 1113 induced brain damage (mice), 349 tigny, C.: In vivo electrophysiological Martin, W. R., see Hamann, S. R., 707 3,4-Methybenedioxymethamphetamine evidence for a selective modulation Masaki, M. A., see Young, A. M., 246 decrease in tryptophan hydroxylase activ- of N-rnethyb-D-aspartate-induced Mas-Chamberlin, C., see Flinois, J.-P., 381 ity, flunarizine and nimodipine ef- neuronal activation in rat CA, dorsal Mast cells, cytokine production, rapamycin fects (rats), 586 hippocampus by sigma ligands, 123 and FK506, 970 lasting effects on central serotonergic Monoamine oxidase, toxicity of 1-methyl-4- Mattson, M. V., see Schweri, M. M., 936 neurons, nonhuman primates, 616 phenyl-1,2,3,6-tetrahydropyridine, May, S. A., see Carroll, M. E., 26 Methylmercury, divalent inorganic mercury primary cultures, astrocytes (mice), McAuley, M. A. and Westfall, T. C.: Possi- and, nerve terminal and intrater- 44 ble location and function of neuro- minal mitochondrial membrane po- Mononitrates, organic, vasodilating action peptide Y receptor subtypes in the tentials, 166 (rats), 692 rat mesenteric arterial bed, 863 n-Methylnicotinamide, kidney multidrug Moreau, J.-L., see Facklam, M., 1113 McConnell, I., see Kinter, L. B., 462 transporter, cyclosporine effect, cob- Morin, D., see Buckpitt, A., 364 McDonald, B. J., see Bennett, B. M., 716 chicine secretion (rats), 50 Morin, D., see Pbopper, C. G., 353 MCI-154, beneficial effect on ischemic con- Methylphenidate, binding site, fourphit as Morphine tractibe failure, myocardial acidosis, selective probe, dopamine trans- differential influence of N-dealkylation, heart (dogs), 1087 porter (rats), 936 stimulus properties, opioid agonists McMahon, E. G., see Olins, G. M., 1037 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyri- (monkeys), 278 McNamara, P. J., Burgio, D. and Yoo, S. dine, toxicity in primary cultures, as- discriminative stimulus effects, agonist D.: Pharmacokinetics of cimetidine trocytes (mice), 44 and antagonist effects, mu opioids during lactation: Species differences D-Methyl-phenylalanyl-prolyl-arginal, (rats), 246 in cimetidine transport into rat and pharmacological assessment of anti- 13-endorphin and, analgesia and release of rabbit milk, 918 thrombotic activity, model, coronary met-enkephalin, forebrain (rats), MDCK cells, monolayers, nonionic diffu- artery thrombosis (dogs), 546 1028 sion, salicylic acid, 1071 Michel, I. M., see Harris, D. N., 131 -induced antinociception Mecamybamine, opioid and nicotinic anal- Middlemiss, D. N., see Francis, P. T., 1273 dynorphin A, spinal antianalgesic ac- gesic and hyperalgesic loci, brain Mihic, S. J., Kalant, H., Liu, J.-F. and Wu, tion of capsaicin (mice), 643 stern (rats), 707 P. H.: Role of the ‘y-aminobutyric naloxone and norbinaltorphimine, Mecca, T. E., see Fenoy, F. J., 470 acid receptor/chloride channel com- spinal dynorphin A (1-17) (mice), 146 Medzihradsky, F., see Bertalmio, A. J., 278 plex in tolerance to ethanol and intravenous cocaine and, cardiovascular Mehta, I., see Murray, M., 373 cross-tolerance to diazepam and pen- and subjective effects (humans), 623 Meijer, D. K. F., see Van Dyke, R. W., 1 tobarbital, 108 locomotor activity, acute sensitivity, Membrane potentials, mitochondrial, com- Milicic, I., see Fenoy, F. J., 470 FAST and SLOW mice, 525 parative action, methylmercury and Milk, lactation, pharmacokinetics of cime- modulation of discriminative stimulus ef- divalent inorganic mercury, 166 tidine (rats, rabbits), 918 fects, cocaine, mu and kappa opioids Mercuric chloride, -induced cytotoxicity and Miller, L. G., Galpern, W. R., Byrnes, J. J., (monkeys), 607 compensatory hypertrophy, kidney Greenblatt, D. J. and Shader, H. I.: nicotine and, differential activation, brain proximal tubular cells (rats), 819 Chronic benzodiazepine administra- dopamine (rats), 484 Mesentery tion. X. Concurrent administration pharmacodynamics and pharmacoki- arterial bed, location and function, neu- of the peripheral-type benzodiaze- netics, spontaneously hypertensive ropeptide Y receptor subtypes (rats), pine ligand PK11195 attenuates and normotensive rats, 290 863 chronic effects of borazepam, 285 time course of distribution in brain and sympathetic neurotransmission, failure to Millington, W. R., Mueller, G. P. and La- spinal cord, intravenous injection alter prejunctional adrenoceptor vigne, G. J.: Cholecystokinin-A and (rats), 1008 modulation, chronic epinephrine cholecystokinin-B receptor antago- use of 2-hydroxypropyl-3-cyclodextrin, treatment (rats), 924 nists produce opposing effects on intrathecal drug vehicle (rats), 592 Mesulergine, spinal 5-HT1 binding sites chobecystokinin-stimulated /3-endor- withdrawal syndrome, role, different (rats), 161 phin secretion from the rat pituitary, brain structures (rats), 669 Met-enkephalin, 9-endorphin and morphine 454 Motor activity, amphetamine-stimulated, for analgesia, forebrain (rats), 1028 Milrinone, beneficial effect of MCI-154, is- block by quinpirole microinjection, Methadone chemic contractile failure, myocar- AlO dopamime region (rats), 811 discriminative stimulus effects of mor- dial acidosis (dogs), 1087 Mucosa phine, agonist and antagonist effects, Miniscalco, A., Lundahl, J., Rega#{226}rdh, C. jejunal mu opioids (rats), 246 G., Edgar, B. and Eriksson, U. G.: neurokinin receptors, ion transport -maintained volunteers, acute effects, bu- Inhibition of dihydropyridine metab- (pigs), 1213 prenorphine/hydromorphone/nalox- olism in rat and human liver micro- sodium and bicarbonate secretion, sub- one, 985 somes by flavonoids found in grape- stance P (pigs), 1206 modulation of discriminative stimulus ef- fruit juice, 1195 Mueller, G. P., see Miblingtom, W. R., 454 fects, cocaine, mu and kappa opioids Mishra, P. K., see Yam, Q.-S., 652 Mugridge, K. G., see Perretti, M., 1238 (monkeys), 607 Mistry, M., see Fenoy, F. J., 470 Muirhead, D., see Speeg, K. V., 50 1992 Index 1303

Multidrug resistance nists, vascular smooth muscle (rats), brorno-2-chloro- 1,1-difluoroethene, kidney multidrug transporter, cycbospor- 506 1248 me effect, cobchicine secretion (rats), phosphorylation-independent contrac- surface binding and intracellular uptake, 50 tion, induction by phorbol ester, vas- gentamicin, LLC-PK, cells, 1200

MDR gene expression, postnatal deveb- cular smooth muscle (rats), 497 Nerve, vasodilator, susceptibility to Ca opment of organic cation transport, antagonists, cerebral arteries (dogs), Nabeshima, T., see Ishimaru, H., 349 kidney (mice), 1222 234 Nakajima, T., Shinohara, T., Yaoka, 0., Fu- Murgo, A. J. and Sistare, F. D.: K562 Leu- Neuroblastoma, emulsifier for intravenous kunari, A., Shinagawa, K., Aoki, K., kemia cells express P’r (adenosine cyclosporin, inhibition of neunite out- Katoh, A., Yamanaka, T., Setoguchi, diphosphate) purinergic receptors, growth, 803 M. and Tahara, T.: Y-27152, A long- 580 Neuroleptics, nonresponsive and responsive acting K channel opener with less Murray, C. R., see Parsons, A. M., 1213 lines, D1 and D2 dopamine receptor tachycardia: Antihypertensive effects Murray, M., Cantrill, E., Mehta, I. and Far- distribution (mice), 341 in hypertensive rats and dogs in con- rell, G. C.: Impaired expression of Neurones, neocortical pyramidal, 5-HTIA scious state, 730 microsomal cytochrome P450 2C11 receptors, intrastriatal volkensin Nakajima, T., Wang, R.-S., Katakura, Y., in choline-deficient rat liver during (rats), 1273 Kishi, R., Elovarra, E., Park, S. S., the development of cirrhosis, 373 Neurons Gelboin, H. V. and Vainio, H.: Sex-, Murthy, J. N., see Pranzatelli, M. R., 161 central serotonergic, 3,4-methylenediox- age,- and pregnancy-induced changes Muscle ymethamphetamine, nonhuman pri- in the metabolism of toluene and tn- aortic rings, relaxant effects, $-carbolines mates, 616 chloroethylene in rat liver in relation (rats), 534 dopamine, inhibition by 1-hydroxy-3- to the regulation of cytochrone longitudinal, myenteric plexus, cholecys- aminopyrrolidone-2, substantia nigra P45OIIE1 and P45OIIC11 content, (rats), 387 tokinin receptors (guinea pigs), 1056 869 papillary, inhibition of positive inotropic entenic Nalbuphine, discrimination of agonist-an- neurokinin receptors and mucosal ion responses, serotonin and catechol- tagonist opioids, two-choice saline- amines transport, jejunum (pigs), 1213 (rabbits), 1160 hydromorphone (humans), 62 Muscle, smooth sodium and bicarbonate secretion, sub- Naboxone stance P (pigs), 1206 contraction in coronary artery, compari- acute effects, methadone-maintaimed vol- sion, serotonin receptors (dog, pig), locus ceruleus, sensitization during with- unteers, 985 856 drawal, chronic stimulants and anti- spinal morphine-induced antinociception, depressants (rats), 476 penile tissues, functional effects, endothe- analgesic action, spinal dynorphin A models of peripheral sympathetic auto- bin-i (humans, rabbits), 795 (1-17) (mice), 146 regulation, role of neuronal hista- phasic responses to carbachol, augmen- Naltrexone, modulation of discriminative mine (rats), 943 tation by cooling, trachea (guinea stimulus effects, cocaine, mu and pigs), 755 serotonergic, activation, carbamazepine kappa opioids (monkeys), 607 and antiepilepsinine (rats), 652 susceptibility to Ca antagonists, cere- Naphazoline, alpha adrenoceptor subtypes, Neuropeptide Y bral arteries (dogs), 234 emetic action (dogs), 746 -induced potentiation, d-myo-inositol-1,2, urinary bladder, blocking action of tero- Naphthalene 6-trisphosphate effects, various vas- diline, calcium channels (guinea epoxidation, cytochrome P-450 activity, oconstnictor agents (rats), 1147 pigs), 724 Clara cell cytotoxicity (mice, ham- receptor subtypes, location and function, vascular sters, rats, monkeys), 364 mesenteric arterial bed (rats), 863 mechanism of vasodilating action, ber- parenteral administration, cytochrome P- sigma ligand and, suppression, stress-in- berine (guinea pigs), 318 450 activity, Clara cell cytotoxicity duced colonic motor disturbances myosin and contractions, induction by (mice, rats, hamsters), 353 (rats), 850 receptor agonists (rats), 506 Narimatsu, A., see Abe, Y., 1087 Neurotoxicity myosin phosphorylation-independent Nasal mucosa decrease in tryptophan hydroxylase activ- contraction, induction by phorbol es- cytochrome P-450 activity ity, calcium channel blockers, meth- ter (rats), 497 Clara cell cytotoxicity, naphthalene amphetamine (rats), 586 Muscularis mucosae, pharmacologic char- (mice, rats, hamsters), 353 3,4-dihydroxymethamphetamine, 2,4,5- acterization, three regions of colon Clara cell cytotoxicity, naphthalene trihydroxymethamphetarnine effects, 1136 (rabbits), epoxidation (mice, hamsters, rats, central serotonergic and dopami- Myenteric plexus, ileum longitudinal mus- monkeys), 364 nergic systems (rats), 447 dc, mediation of contraction, chole- Nasjletti, A., see Pucci, M. L., 240 Neurotransmission, sympathetic, chronic cystokinin receptors (guinea pigs), Natriuresis epinephrine treatment, prejunctional 1056 renal sympathetic nerve activity, cboni- adrenoceptors (rats), 924 Myers, A., see Thomas, G., 875 dine effects, chronic congestive heart Neutral metalboendopeptidase, localization Myles, J. L., see Foy, R. A., 601 failure (rats), 1129 and characterization, kidney (rats), Mynderse, J. S., see Hatfield, S. M., 970 water and solute excretion, opposite rank 1231 Myocardium order of potency (rats), 1080 Neve, K. A., see Jamowsky, A., 1282 acidosis and isehemic contractile failure, Near, J. A., see Wiedemann, D. J., 574 Newport, G. D., see Bowyer, J. F., 72 beneficial effect, MCI-154 (dogs), Nelson, J. A., see Dutt, A., 1222 Newsholme, S. J., see Zhou, H.-L., 1260 1087 Nemec, J., see Relling, M. V., 491 Nicotine ventricular, effect of ketamine HC1, nor- Neomycin, -sensitive calcium channels, analgesic and hyperalgesic loci, brain epinephrine disposition (ferrets), 101 brain slices (rats), 324 stem (rats), 707 Myocytes Neonate ethanol and, classical genetic analyses, cardiac, sodium channel blocking proper- breathing, in utero cocaine exposure long- and short-sleep mice, 173 ties, major metabolites of cocaine (guinea pigs), 420 interference with renal organic cation (guinea pigs), 910 developmental differences, erythropoietin transport, plasma, habitual tobacco ventricular, disopyramide block of sodium pharmacokinetics, 977 smokers (rats), 21 current, removal of fast inactivation Nephron, collecting tubule transport en- locomotor activity, acute sensitivity, process (guinea pigs), 1167 zymes, lithium and amiloride (rats), FAST and SLOW mice, 525 Myosin 701 morphine and, differential activation, phosphorylation-dependent and -inde- Nephrotoxicity brain dopamine (rats), 484 pendent contractions, receptor ago- glutathione and cysteine conjugates, 2- punishment of schedule-controlled be- 1304 Index Vol. 261

havior, /3-carboline injections (mom- role of different brain structures, mor- Pangalos, M. N., see Francis, P. T., 1273 keys),138 phine withdrawal syndrome (rats), Papachristou, D. N., see De Waele, J.-P., Nies, A. S., see Gilmore, D. A., 1181 669 788 Nifedipine Nucleus tractus sobitarius, baroreflex Pardridge, W. M., Buciak, J. L. and Yoshi- block of angiotensin Il-mediated vasocon- changes, serotonergic or catechola- kawa, T.: Transport of recombinant striction (humans), 879 minergic lesions (rats), 225 CD4 through the rat blood-brain bar- phasic responses to carbachol, augmen- rier in vivo, 1175 tation by cooling, trachea (guinea Ogasawara, S., see Hikasa, Y., 746 Parent, C., B#{233}langer,P. M., Jutras, L. and pigs), 755 Ogletree, M.L., see Harris, D. N., 131 Du Souich, P.: Effect of inflamma- Nimodipine, flunarizine and, decrease in O’Grady, S. M., see Brown, D. R., 1206 tion on the rabbit hepatic cytochrome Ohishi, Y., see Hori, R., 1200 tryptophan hydroxylase activity, P-450 isoenzymes: Alterations in the Ohkawara, Y., see Ohrui, T., 1268 methamphetamine (rats), 586 kinetics and dynamics of tolbuta- Ohrui, T., Yamauchi, K., Sekizawa, K., Nishida, A., see Miyata, K., 297 mide, 780 Ohkawara, Y., Maeyama, K., Sasaki, Nishio, S., see Pbopper, C. 0., 353 Parente, L., see Perretti, M., 1238 M., Takemura, M., Wads, H., Wa- Nitric acid, pharmacologic characterization, Park, S. S., see Nakajima, T., 869 tanabe, T., Sasaki, H. and Takish- muscularis mucosae, colon (rabbits), Parkinsonism, toxicity of 1-methyl-4- ima, T.: Histamine N-methyltrans- 1136 phenyl-1,2,3,6-tetrahydropyridine, ferase controls the contractile re- Nitric oxide primary cultures, astrocytes (mice), sponse of guinea pig trachea to pressor and renal vasoconstrictor effects, 44 histamine, 1268 NG.nitroLarginine (rats), 240 Parsons, A. M., see Brown, D. R., 1206 Okamura, T., see Toda, N., 234 relaxation induced by acetylcholine, cer- Parsons, A. M., Seybold, V. S., Chandan, ebral arteries (cats), 12 Okuda, M., see Hori, R., 1200 Okumura, H., see Koumi, S.-I., 1167 R., Vogt, J., Larson, A. A., Murray, Nitric oxide synthase, constitutive, impair- C. R., Soldani, G. and Brown, D. R: ment by calmodulin inhibitors, aorta Olins, G. M., Corpus, V. M., McMahon, E. G., Pabomo, M. A., Schuh, J. R., Neurokinin receptors and mucosal (rats), 553 ion transport in porcine jejunum, NGNitroLarginine, pressor and renal vas- Blehm, D. J., Huang, H.-C., Reitz, D. B., Manning, R. E. and Blame, E. H.: 1213 oconstrictor effects, sympathetic Patacchini, R. and Maggi, C. A.: Effect of nervous system, angiotensin (rats), In vitro pharmacology of a nonpep- tidic angiotensin II receptor antago- newly developed tachykinin agonist 240 and antagonists on the guinea pig Nitroglycerin, central actions, cbonidine nist, SC-51316, 1037 isolated gallbladder, 191 binding sites, cortex membranes Oliveto, A. H., Bickel, W. K., Hughes, J. R., Shea, P. J., Higgins, S. T. and Fen- Patch clamp, dual effects of pyrazole, (rats), 1187 wick, J. W.: Caffeine drug discrimi- NMDA receptors, hippocampal py- S-Nitrosothiols, relaxant properties of air- nation in humans: Acquisition, spec- ramidal cells (rats), 331 ways (guinea pigs), 154 ificity and correlation with self-re- PD 121981, cardiac angiotensin receptors Nitrous oxide, exposure of cultured cells, ports, 885 (rabbits), 931 homocysteine remethylation, folates, Olsen, G. D. and Weil, J. A.: In utero cocaine Pearson, R. C. A., see Francis, P. T., 1273 1096 exposure: Effect on neonatal breath- Penis, functional effects of endothelin-1 Noble, F., Soleilhace, J. M., Soroca-Lucas, ing in guinea pigs, 420 (humans, rabbits), 795 E., Turcaud, S., Fournie-Zaluski, M. Onori, L., see Rizzi, C. A., 412 Penner, S. B., see Smyth, D. D., 1080 C. and Roques, B. P.: Inhibition of Opiates, morphine withdrawal syndrome, Pentazocine, discrimination of agonist-an- the enkephalin-metabolizing en- role, different brain structures (rats), tagonist opioids, two-choice saline- zymes by the first systemically active 669 hydromorphone (humans), 62 mixed inhibitor prodrug RB 101 in- Opioids Pentobarbital duces potent analgesic responses in agonist-antagonist, discrimination, two- cross-tolerance, tolerance to ethanol, mice and rats, 181 choice saline-hydromorphone (hu- GABA receptor/chloride channel Noradrenaline, sensitization of locus ceru- mans), 62 complex (rats), 108 leus neurons, during withdrawal agonists, N-deabkylation, stimulus prop- discriminative stimulus effects of mor- (rats), 476 erties (monkeys), 278 Norbinaltorphimine, spinal morphine-in- phine, agonist and antagonist effects, intrathecal drug vehicle, use of 2-hydrox- mu opioids (rats), 246 duced antinociception, spinal dynor- ypropyl-3-cyclodextrin (rats), 592 3-endorphin and morphine for analgesia, phin A (1-17) (mice), 146 mu, agonist and antagonist effects, dis- forebrain (rats), 1028 Norepinephrine criminative stimulus effects of mor- amplification of arterial contractile re- locomotor activity, acute sensitivity, phine (rats), 246 FAST and SLOW mice, 525 sponse, angiotensin II, protein kinase mu and kappa, modulation of discrimi- Rose, C (rabbits), 835 Percy, W. H., K. and Burton, M. B.: native stimulus, cocaine (monkeys), Pharmacologic characterization of disposition in ventricular myocardium, ef- 607 the muscularis mucosae in three re- fect of ketamine HC1 (ferrets), 101 nicotinic and hyperalgesic loci, brain stem inhibition of positive inotropic responses, gions of the rabbit colon, 1136 (rats), 707 Pereira, E. F. R., Aracava, Y., Aronstam, R. serotonin and catecholamines, papil- pharmacologic activity of CI-977 (mon- S., Barreiro, E. J. and Albuquerque, bary muscle (rabbits), 1160 1044 keys), E. X.: Pyrazole, and alcohol dehy- phosphorylation-independent vascular Osborne, J. A., see Jansen, A., 154 drogenase inhibitor, has dual effects contraction, receptor agonists (rats), Overlack, C., see Lemoine, H., 258 on N-methyl-D aspartate receptors of 506 Oximes, dual action of 2,3-butanedione hippocampalpyramidal cells: Agonist prejunctional apha-2 adrenergic recep- monoxime, potassium current, T and noncompetitive antagonist, 331 tons, adrenergic transmitter release cells (humans), 438 Periaqueductal gray, robe of different brain (rats), 1050 Oxodipine, metabolism rate (rats, humans), structures, morphine withdrawal regional differences in effects of septic 381 syndrome (rats), 669 shock, vascular reactivity (rabbits), Oxymetazoline, alpha adrenoceptor sub- 959 types, emetic action (dogs), 746 Penistalsis, acetylcholine releasing proper- renal sympathetic nerve activity, cboni- Ozaki, H., see Hori, M., 506 ties, benzimidazobone derivatives, dine effects, chronic congestive heart Ozaki, H., see Sato, K., 497 ileum (guinea pigs), 412 failure (rats), 1129 Perretti, M., Mugridge, K. G., Wallace, J. Nucleus accumbens Padrini, R., see Bova, S., 318 L. and Parente, L.: Reduction of as- differential activation of dopamine, nic- Pahapill, P. A., see Schlichter, L. C., 438 pirin-induced gastric damage in rats otine and morphine, brain (rats), 484 Palomo, M. A., see Olins, G. M., 1037 by interleukin-lfl: Possible involve- 1992 Index 1305

ment of endogenous corticosteroids, Plasma, dopa responses during stress, sym- G. E.: Discrimination of agonist-an- 1238 pathoneural activity, tyrosine hy- tagonist opioids in humans trained Perrier, M. L., Scatton, B. and Benavides, droxylation (rats), 899 on a two-choice saline-hydromor- J.: Dihydropyridine- and w-cono- Pbatelet-activating factor, reduction of phone discrimination, 62 toxin-resistant, neomycin-sensitive spinal cord blood flow, behavioral Preston, K. L., see Strain, E. C., 985 calcium channels mediate the depo- deficits, receptor mechanism (rats), Priebe, T. S., see Dutt, A., 1222 larization-induced increase in inter- 1064 Prolactin, regulation, maternal bile secre- nal calcium bevels in cortical slices Platelets tory function, postpartum (rats), 560 from immature rat brain, 324 block of 5-HT2 receptors, delay of occlu- Propanol, locomotor activity, acute sensitiv- Perry, K. W., see Gong, L., 1000 sion, LY215840 (rabbits), 202 ity, FAST and SLOW mice, 525 Pertussis toxin, -insensitive mechanisms, pharmacological characterization, SQ 33, Prophylthiouracil, -induced peninatal hy- dual effects, field-stimulated ileum 261 and SQ 33,552 (humans, rats, pothyroidism, ontogeny of beta adre- (guinea pigs), 1253 guinea pigs, mice), 131 nergic receptors, heart and kidney pH, sodium and bicarbonate secretion, sub- -rich mural thrombosis model, compara- (rats), 951 stance P, jejunal mucosa (pigs), 1206 tive antithrombotic effects, heparin/ Propranolob, stereoselective pharmacoki- Phencyclidine hirudin/argatroban (hamster), 895 netics, age and gender influences (hu- buprenorphine’s effects on self-adminis- Pleus, R. C. and Bybund, D. B.: Desensiti- mans), 1181 tration, smoked cocaine base, ethanol zation and down-regulation of the 5- Prostacyclin, production, adenosine recep- and saccharin (monkeys), 26 hydroxytryptaminelB receptor in the tor-mediated alterations, heart (rab- NMDA receptor antagonists, carbon opossum kidney cell line, 271 bits), 660 monoxide-induced brain damage Pbopper, C. G., see Buckpitt, A., 364 Prostaglandin F2, phosphorylation-inde- (mice), 349 Pbopper, C. G., Suverkropp, C., Morin, D., pendent vascular contraction, recep- Phenobarbital Nishio, S. and Buckpitt, A.: Relation- ton agonists (rats), 506 impaired bibiary excretion, acetamino- ship ofcytochrome P-450 activity due Prostanoids, pressor and renal vasoconstric- phen glucuronide, liver (rats), 1022 to Clara cell cytotoxicity. I. Histo- tor effects, NGnitroLarginine, sym- increased sensitivity to anesthetic effect, pathologic comparison of the respi- pathetic nervous system (rats), 240 aging BN/BiRij rats, 81 ratory tract of mice, rats and ham- Protein kinase, cyclic AMP and, agonist- locomotor activity, acute sensitivity, sters after parenteral administration related differences, trachealis (dogs), FAST and SLOW mice, 525 of naphthalene, 353 1260 Phenybephrine Pluchino, R. S., see Pranzatelli, M. R., 161 Protein kinase C, amplification of arterial alpha adrenoceptor subtypes, emetic ac- Polyamines contractile response, angiotensin II, tion (dogs), 746 binding site of NMDA receptor, agonists norepinephrine (rabbits), 835 block of angiotensin Il-mediated vasocon- and antagonists, alteration of general Proximal tubular cells, mercuric chloride- stniction, calcium antagonists (hu- anesthetic potency (mice), 304 induced cytotoxicity, compensatory mans), 879 NMDA receptor antagonists, carbon hypertrophy (rats), 819 Phillips, T. J., Burkhart-Kasch, S., Gwiaz- monoxide-induced brain damage Pucci, M. L., Lin, L. and Nasjletti, A.: Pres- don, C. C. and Crabbe, J. C.: Acute (mice), 349 son and renal vasoconstnictor effects sensitivity of FAST and SLOW mice Potassium of N’-nitro-L-arginine as affected by blockade of pressor mechanisms me- to the effects of abused drugs on bo- antihypertensive effects of Y-27152 (rats, diated by the sympathetic nervous comotor activity, 525 dogs), 730 system, angiotensin, prostanoids and Phorbol ester, induction of myosin phos- depolarization, glutamate-evoked dopa- vasopressin, 240 phorylation-independemt contrac- mine release, striatal slices (rats), 72 Punishment, schedule-controlled behavior, tion, vascular smooth muscle (rats), Potassium channel fl-carboline injections (monkeys), 138 497 activator celikalim, electromechanical ef- Purines, pharmacologic characterization, Phosphatidylcholine, NMDA-increased fects, atrial and ventricular muscle muscularis mucosae, colon (rabbits), acetylchobine release, augmentation (cats), 1153 1136 by choline, striatum and cortex ATP-sensitive, inhibition by glibenclam- Pyrazole, dual effects on NMDA receptors, (rats), 1122 ide, cardiac muscle (guinea pigs), 540 hippocampal pyramidal cells (rats), 3’-Phosphoadenosine 5’-phosphosulfate, Potassium current, dual action of 2,3-buta- 331 sulfate and, homeostasis, acetamino- nedione monoxime, T cells (humans), phen adminstration (rats), 1015 438 Qian, Y., Hitzemann, B. and Hitzemann, R.: Phosphoenzyme, gastric HC1 secretion, in- Pracyk, J. B. and Sbotkin, T. A.: Thyroid D1 and D2 dopamine receptor distni- beta hibitor of H,K-ATPase, AHR-9294 hormone regulates ontogeny of bution in the neuroleptic nonnespon- (rats, dogs), 737 adrenergic receptors and adenylate sive and neuroleptic responsive lines Pietra, C., see Dab Forno, G., 1056 cyclase in rat heart and kidney: Ef- of mice, a quantitative receptor au- Pimobendan, beneficial effect of MCI-154, fects ofpropylthiouracil-induced per- toradiographic study, 341 ischemic contractile failure, myocar- inatal hypothyroidism, 951 Quadazocine, alfetanil- and cocaine-rein- dial acidosis (dogs), 1087 Pranzatelli, M. R., Murthy, J. N. and Plu- forced responding, effects of bupren- Pinacidil, inhibitory effects, cromakalim chino, R. S.: Identification of spinal orphine (monkeys), 311 and BRL 38227, airways (guinea pigs, 5-HT, binding sites in the rat: Char- Quinpirole, microinjection into AlO dopa- humans), 429 actenization of [3Hjmesulergine bind- mine region, block, amphetamine- Pinkus, L. M., see Reenstra, W. W., 737 ing, 161 stimulated motor activity (rats), 811 Pirenzipine, phasic responses to carbachol, Prazosin, alpha adrenoceptor subtypes, augmentation by cooling, trachea emetic action (dogs), 746 Radioligands, spinal 5-HT1 binding sites, (guinea pigs), 755 Prefrontal cortex, differential activation of [3Hjmesubergine binding (rats), 161 Pituitary dopamine, nicotine and morphine, Rae, G. A., see Guimar#{227}es, C. L., 1253 3-endorphin secretion, cholecystokinin-A brain (rats), 484 Rahmani, N. H., see Bhargava, H. N., 1008 and -B receptor antagonists (rats), Pregnancy Ramwell, P. W., see Farhat, M. Y., 686 454 -induced changes in metabolism, toluene Ramwell, P. W., see Thomas, G., 875 intermediate, direct in vitro electrochem- and trichloroethylene, liver (rats), Ranitidine, kidney multidrug transporter, ical measurement, dopamine over- 869 cyclosporine effect, colchicine secre- flow (rats), 403 maternal bile secretory function postpar- tion (rats), 50 PK11195, attenuation of chronic effects of tum, regulation by prolactin (rats), Rapamycin, FK506 and, mast cell cytokine borazepam, chronic benzodiazepine 560 production, reciprocal antagonists, administration (mice), 285 Preston, K. L., Liebson, I. A. and Bigelow, 970 1306 Index Vol. 261

RB 101, inhibition of enkephalin-metaboliz- sodium and bicarbonate secretion in je- Roch-Ramel, F., see Chatton, J.-Y., 518, ing enzymes, analgesic responses junal mucosa, substance P (pigs), 1071 (mice, rats), 181 1206 Roehm, N. W., see Hatfield, S. M., 970 Receptors neuropeptide Y, location and function of Roman, R. J., see Fenoy, F. J., 470 adenosine, alterations in prostacyclin subtypes, mesenteric arterial bed Roques, B. P., see Noble, F., 181 production, heart (rabbits), 660 (rats), 863 Rorie, D. K., see Cook, D. J., 101 adenosine diphosphate puninergic, K562 NMDA, alteration of general anesthetic Rose, K., see Percy, W. H., 1136 cells, 580 potency, agonists and antagonists Rozman, P., see Kim, H. J., 1015 agonists, myosin phosphorylation and (mice), 304 RU 38486, reduction of aspirin-induced gas- contractions, vascular smooth muscle non-NMDA, inhibition of dopamine neu- tric damage, interleukin i, cortico- (rats), 506 rons, 1-hydroxy-3-aminopyrroli- steroids (rats), 1238 alpha-2 adrenoceptor agonists and, oppo- done-2 (rats), 387 Sabatini, S., see Dafnis, E., 701 site rank order of potency, water and occupancy, benzodiazepine, GABA-stim- Sabieraj, J., see Safayhi, H., 1143 solute excretion (rats), 1080 ulated chloride flux (rats), 1106 Sabin, C., see Chiu, P. J. S., 994 angiotensin, DUP 753 and PD 121981, platelet-activating factor, reduction, Saccharin, buprenorphine’s effects on self- heart (rabbits), 931 spinal cord blood flow (rats), 1064 administration, smoked cocaine base, angiotensin II, antagonist SC-51316 serotonin, mediation of smooth muscle phencyclidine and ethanol (mon. (rats), 1037 contraction, coronary artery (dog, keys), 26 atypical, beta adrenoceptors, brown fat pig), 856 Sadeghi, H. M. and Eikenburg, D. C.: adenylyb cyclase (rats), 633 thromboxane, antagonists SQ 33,261 and Chronic epinephrine treatment fails benzodiazepine, occupancy, functional ef- SQ 33,552, pharmacological charac- to alter prejunctional adrenoceptor fects of bigands (mice), 1113 terization (humans, rats, guinea pigs, modulation of sympathetic neuro- cholecystokinin mice), 131 contraction, ileum longitudinal muscle transmission in the rat mesentery, Reenstra, W. W., Pinkus, L. M., Bailey, J., 924 myenteric plexus (guinea pigs), 1056 Smith, W. L., Droppleman, D., San- neuropeptide Y, stress-induced colonic Safayhi, H., Mack, T., Sabieraj, J., Anazodo, cilio, L. F. and Forte, J. G.: AHR- M. I., Subramanian, L. R. and Am- motor disturbances (rats), 850 9294: A novel inhibitor of H,K-AT- cholecystokinin-A and -B, antagonists, fi- mon, H. P. T.: Boswellic acids: Novel, Pam antagonizes gastric HCI secre- specific nonredox inhibitors of 5-li- endorphin secretion from pituitary tiom in vivo, 737 (rats),454 poxygenase, 1143 Refsum, H., see Christensen, B., 1096 dopamine Dl, pulmonary artery, endothe- Saito, H., see Inui, K.-I., 195 Reg#{226}rdh,C. G., see Miniscalco, A., 1195 Sakata, K., see Hori, M., 506 hal cells (rabbits), 830 Reitz, D. B., see Olins, G. M., 1037 dopamine D2, region-specific regulation, Salaices, M., see Alonso, M. J., 12 Relling, M. V., Evans, R., Dass, C., Desi- Salicylic acid clozapine 1 (rats), 1282 derio, D. M. and Nemec, J.: Human dopamine Dl and D2, neuroleptic nonnes- nonionic diffusion, MDCK cell mono- cytochrome P450 metabolism often- ponsive and responsive lines (mice), layers, 1071 iposide and etoposide, 491 341 transport through monolayers, kidney ep- Renin, antihypertensive effects of Y-27152 ithelial cell line, 518 GABAA, chloride channels, borazepam tol- (rats,dogs), 730 erance and withdrawal (mice), 395 Sanchez-Ferrer, C. F. , see Alonso, M. J., 12 Renin-angiotensin system see Reenstra, W. W., 737 GABA/chloride channel complex, toler- Sancilio, L. F., inhibition, reduction, glycine-induced gb- ance to ethanol, cross-tolerance to Sanger, D. J.: Increased rates of punished merular hyperfiltration (rats), 96 diazepam and pentobarbital (rats), responding produced by buspirone- SC-51316 pharmacology (rats), 1037 108 like compounds in rats, 513 Respiration, neonatal breathing, in utero 5-HT Sasaki, H., see Ohrui, T., 1268 cocaine exposure (guinea pigs), 420 bovine coronary arteries, 601 Sasaki, M., see Ohrui, T., 1268 Retinoic acid, retinoid-mimetic effects, ha- supersensitization of oral response, Sato, K., Hori, M., Ozaki, H., Takano- rozole (rats, hamsters), 773 SKF 38393 (rats), 1000 Ohmuro, H., Tsuchiya, T., Sugi, H. Ricaurte, G. A., Martelbo, A. L., Katz, J. L. 5-HT2, block by LY215840, model of and Karaki, H.: Myosin phosphoryl- and Martelbo, M. B.: Lasting effects thrombosis (rabbits), 202 ation-independent contraction in- of (±)-3,4-methylenedioxymetham- 5-HT3, stress-induced defecation (rats), duced by phorbol ester in vascular phetamine (MDMA) on central se- 297 smooth muscle, 497 rotonergic neurons in nonhuman pri- 5-HT4, benzimidazobone derivatives, Sato, K., see Hori, M., 506 mates: Neurochemical observations, ileum (guinea pigs), 412 Sato, R., see Koumi, S.-I., 1167 5-HTIA 616 SC-51316, pharmacology (rats), 1037 buspirone-bike compounds, increased Ricci, A., Collier, W. L. and Amenta, F.: Scatton, B., see Perrier, M. L., 324 Endothelial dopamine DA-1 receptor rates of punished responding (rats), SCH 23390, acute administration of am- sites in the rabbit pulmonary artery: 513 phetamine, regulation, dopamine neocortical pyramidal neurones, de- Autoradiographic demonstration, synthesis (rats), 567 struction by intrastriatal volkensin 830 Schini, V. B. and Vanhoutte, P. M.: Inhibi- (rats), 1273 Rice, K. C., see Schweri, M. M., 936 tors of calmodulin impair the consti- 5-HT1B, desensitization and down-regu- Rivelli, M., see Chiu, P. J. S., 994 tutive but not the inducible nitric lation, kidney cell line (opossum), Rizzi, C . A., Coccini, T., Onori, L., Manzo, oxide synthase activity in the rat 271 L. and Tonini M.: Benzimidazobone aorta, 553 5-HT,, binding sites, mesulergine bind- derivatives: A new class of 5- Schlichter, L. C., Pahapill, P. A. and Chung, ing (rats),161 hydroxytryptamine4 receptor ago- I.: Dual action of 2,3-butanedione N-methyb-D-aspartate nists with prokinetic and acetylcho- monoxime (BDM) on K current in antagonists, carbon monoxide-induced line releasing properties in the guinea human T lymphocytes, 438 brain damage (mice), 349 pig ileum, 412 Schmidt, R. L., see Widness, J. A., 977 dual effects of pyrazole, hippocampal Ro 19-8022 Schoch, P., see Facklam, M., 1106, 1113 pyramidal cells (rats), 331 benzodiazepine receptor occupancy Schuh, J. R., see Olins, G. M., 1037 muscularis mucosae, pharmacologic char- functional effects of ligands, differing Schumacher, W. A., see Harris, D. N., 131 acterization, colon (rabbits), 1136 intrinsic efficacies (mice), 1113 Schwartz, D. D. and Malik, K. U.: Charac- neurokinin GABA-stimulated chloride flux (rats), terization of prejunctional alpha-2 mucosal ion transport, jejunum (pigs), 1106 adrenergic receptors involved in 1213 Robertson, D. W., see Cohen, M. L., 202 modulation of adrenergic transmitter 1992 Index 1307

release in the isolated perfused rat onists on water and solute excretion gastric HC1 secretion, inhibitor of H,K- kidney, 1050 in the rat: Two sites and/or receptors, ATPase, AHR-9294 (rats, dogs), 737 Schweri, M. M., Thurkauf, A., Mattson, M. 1080 Stone, D. M., see Johnson, M., 586 V. and Rice, K. C.: Fourphit: A selec- Smyth, D. D., see Wong, L. T. Y., 21 Stoppie, P., see Van Wauwe, J., 773 tive probe for the methylphenidate Sodium, bicarbonate secretion and, sub- Strain, E. C., Preston, K. L., Liebson, I. A. binding site on the dopamine trans- stance P, jejunal mucosa (pigs), 1206 and Bigelow, G. E.: Acute effects of porter, 936 Sodium channel, blocking properties of ma- buprenorphine, hydromorphone and Scott, A. L., Chang, R. S. L., Lotti, V. J. and jor metabolites, cocaine, single car- naloxone in methadone-maintained Siegl, P. K. S.: Cardiac angiotensin diac myocytes (guinea pigs), 910 receptors: Effects of selective angio- volunteers, 985 Sodium current, cardiac, disopyramide Stratmann, G. C., see Francis, P. T., 1273 tensin II receptor antagonists, DUP block, removal of fast inactivation Stress 753 and PD 121981, in rabbit heart, process (guinea pigs), 1167 -induced cobonic motor disturbances, neu- 931 nitroprusside, central actions of ni- Sodium ropeptide Y, sigma ligand (rats), 850 Sekizawa, K., see Ohrui, T., 1268 troglycerin, clonidine binding sites, Serotonin -induced defecation, role of serotonin3 re- cortex membranes (rats), 1187 ceptor (rats), 297 acetylcholine releasing properties, ben- Soldani, G., see Parsons, A. M., 1213 zimidazobone derivatives, ileum plasma dopa responses, sympathoneural Soleilhac, J. M., see Noble, F., 181 activity, tyrosine hydroxylation (guinea pigs), 412 Soroca-Lucas, E., see Noble, F., 181 activation of neurons, carbamazepine and (rats), 899 Spasm, activation of relaxation cascade, Striatum antiepilepsirine (rats), 652 coronary arteries, brief electrical baroreflex changes, nucleus tractus soli- glutamate-evoked dopamine release, po- pulses (cattle), 209 tarius (rats), 225 tassium depolarization (rats), 72 Spealmam, R. D. and Bergman, J.: Modula- characterization of 5-HT receptors, bo- NMDA-increased acetylcholine release, tion of the discriminative stimulus vine coronary arteries, 601 augmentation by choline (rats), 1122 effects of cocaine by mu and kappa decrease in tryptophan hydoxylase activ- stimulated synaptic overflow of dopa- opioids, 607 ity, calcium channel blockers, meth- mine, chronic haloperidol treatment Species differences, pharmacokinetics of ci- amphetamine (rats), 586 (rats), 574 metidine, lactation (rats, rabbits), 3,4-dihydroxymethamphetamine, 2,4,5- Studenberg, S. D. and Brouwer, K. L. R.: 918 trihydroxymethamphetamine effects Impaired biliary excretion of aceta- Speeg, K.V., Maldonado, A. L., Liaci, J. and (rats), 447 minophen glucuronide in the isolated Muirhead, D.: Effect of cycbosponine inhibition, beta adrenoceptor-mediated perfused rat liver after acute pheno- on colchicine secretion by the kidney positive inotropic responses, cate- barbital treatment and in vivo phe- multidrug transporter studied in vivo, cholamines in papillary muscle (rab- nobarbital pretreatment, 1022 50 bits), 1160 Subramanian, L. R., see Safayhi, H., 1143 Spinal cord lasting effects on neurons, 3,4-methyle- Substance P antianalgesic action of dynorphin A (1- nedioxymethamphetamine, nonhu- cholecystokinin receptors, mediation of 17), naloxone and norbinaltorphim- man primates, 616 contraction, ileum longitudinal mus- me, morphine-induced antinocicep- metabolism, endotoxin-induced activa- cle myenteric plexus (guinea pigs), tion (mice), 146 tion, interleukin 1 (mice), 964 1056 blood flow reduction, platelet-activating supersensitization of oral response, SKF involvement of dynorphin A, spinal an- factor, receptor mechanism (rats), 38393, neonatal 6-OHDA-lesioned algesic action ofcapsaicin, morphine- 1064 rats, 1000 induced antinociception (mice), 643 5-HT, binding sites, [3H]mesulergine Setoguchi, M., see Nakajima, T., 730 production of sodium and bicarbonate se- binding (rats), 161 Sex differences, toluene and trichloroethyl- cretion, jejunal mucosa, action on en- ene metabolism, liver (rats), 869 intrathecal administration, alpha-2 ago- teric neurons (pigs), 1206 Seybold, V. S., see Parsons, A. M., 1213 nists and antagonists (rats), 764 Substantia nigra, inhibition of dopamine Shader, R. I., see Miller, L. G., 285 time course of morphine distribution, in- neurons, 1 -hydroxy-3-aminopyrroli- Shaw, D. J., see Taylor, S. 0., 429 travenous injection (rats), 1008 done-2 (rats), 387 Shea, P. J., see Oliveto, A. H., 885 SQ 33,261, SQ 33,552 and, pharmacological Sudden infant death, in utero cocaine ex- Shepard, P. D. and Lehmann-Romeyn, H.: characterization (humans, rats, posure, neonatal breathing (guinea (±)-i-Hydroxy-3-aminopyrrolidone- guinea pigs, mice), 131 pigs), 420 2 inhibits the activity of substantia ST-91, intrathecal administration, apka-2 nigra dopamine neurons through a agonists and antagonists (rats), 764 Sufentanil, use of 2-hydroxypropyl-fl-cy- clodextrin, intrathecal drug vehicle non-N-methyl-D-aspartate receptor- Stamler, J. S., see Jansen, A., 154 mediated mechanism, 387 Stassen, J.-M., see Imura, Y., 895 (rats), 592 Shinagawa, K., see Nakajima, T., 730 Steinbacher, T. E., see Harris, D. N., 131 Sugi, H., see Hori, H., 506 Shinohara, T., see Nakajima, T., 730 Steketee, J. D. and Kalivas, P. W.: Microin- Sugi, H., see Sato, K., 497 Shock, septic, region differences, vascular jection of the D2 agonist quinpirole Sulfate, 3’-phosphoadenosine 5’-phospho- reactivity (rabbits), 959 into the AlO dopamine region blocks sulfate and, homeostasis, acetamino- Siegb, P. K. S., see Scott, A. L., 931 amphetamine-, but not cocaine-stim- phen administration (rats), 1015 Sistare, F. D., see Murgo, A. J., 580 ulated motor activity, 811 Sulphonylurea, glibenclamide, inhibition of Sitar, D. S., see Wong, L. T. Y., 21 Stijnen, A. M., Danhof, M. and Van Be- ATP-sensitive K channels, cardiac SKF 38393, supersensitization of oral re- zooijen, C. F. A.: Increased sensitivity muscle (guinea pigs), 540 sponse, neonatal 6-OHDA-lesioned to the anesthetic effect of phenobar- Sun, X. Y., Edvinsson, L. and Hedner, T.: rats, serotonin system, 1000 bital in aging BN/BiRij rats, 81 Effects of d-myo-inositol-1,2,6-tnis- Skjoldager, P., see Winger, G., 311 Stimulants, antidepressants and, sensitiza- phosphate on neuropeptide Y-in- Sleep, long- and short-, responses to nic- tion, locus ceruleus neurons (rats), duced potentiation of various vaso- otine and ethanol, classical genetic 476 constrictor agents in the rat, 1147 analyses, 173 Stinus, L., see Maldonado, R., 669 Suverkropp, C., see Plopper, C. G., 353 Sbotkin, T. A., see Pracyk, J. B., 951 Stitzer, M. L., see Azorbosa, J. L., 114 Suzuki, H., see Ishimaru, H., 349 Smith, G. F., see Jackson, C. V., 546 St. James, M. J., see Bennett, B. M., 716 Sybertz, E. J., see Chiu, P. J. S., 994 Smith, W. L., see Reenstra, W. W., 737 Stomach Sybertz, E. J., see Kanazawa, M., 1231 Smyth, D. D., Li, P., Blandford, D. E. and aspirin-induced gastric damage, reduction Sympathetic nerve, renal, cbonidine effects, Penner, S. B.: Opposite rank order of by interbeukin 13, corticosteroids chronic congestive heart failure potency for alpha-2 adrenoceptor ag- (rats), 1238 (rats), 1129 1308 Index Vol. 261

Sympathetic nervous system ceptors, delay ofocclusion, LY215840 Tsuchiya, T., see Sato, K., 497 pressor and renal vasoconstrictor effects, (rabbits), 202 Tsutsumi, R., see Miyata, K., 297 NGnitro.Larginine (rats), 240 coronary artery, antithrombotic activity, Tukker, E., see Mandema, J. W., 88 sympathoadrenal stimulation, acute pres- D-methyl-phenylalanyb-prolyl-ar- Turcaud, S., see Noble, F., 181 sor response, cyclosporine (rats), 994 ginal (dogs), 546 Tyler, C. B. and Galloway, M. P.: Acute Sympathomimetics, beta-2, conversion to mural, comparative antithrombotic ef- administration of amphetamine: Dif- partial agonists, relaxants of trachea fects, heparin/hirudin/argatroban ferential regulation of dopamine syn- (guinea pigs), 258 (hamster), 895 thesis in dopamine projection fields, Synapse, stimulated overflow of dopamine, Thromboxane, mimic U-46619, potentiation 567 chronic halopenidol treatment, stria- of vasopressor response of lung, es- Tyrosine, hydroxylation, plasma dopa re- turn (rats), 574 tradiol (rats), 686 sponses during stress (rats), 899 meth- Synaptosomes, comparative action of Thromboxane A2, receptor antagonists SQ Tyrosine hydroxylase, 3,4-dihydroxyme- ylmercury and divalent inorganic 33,261 and SQ 33,552, pharmacolog- thamphetamine, 2,4,5-trihydroxyme- mercury, nerve terminal and intra- icab characterization (humans, rats, thamphetamine effects, central sero- terminal mitochondrial membrane guinea pigs, mice), 131 tonergic and dopaminergic systems potentials, 166 Thurkauf, A., see Schweni, M. M., 936 (rats), 447 Thyroid hormone, regulation of ontogeny of Tzeng, T.-B. and Fung, H.-L.: Pharmaco- Tachycardia, antihypertensive effects of Y- beta adrenergic receptors, adenylate 27152 (rats,dogs), 730 kinetic/pharmacodynamic relation- cyclase, heart and kidney (rats), 951 ship of the duration of vasodibating Tachykinin, agonist and antagonists, gall- Tobacco, habitual smokers, interference action of organic mononitrates in bladder (guinea pigs), 191 with renal organic cation transport, Tagliente, T. M., Dalton, B. A. and Ben- rats, 692 nicotine (rats), 21 Harari, to R. R.: Phasic responses Toda, N. and Okamura, T.: Different sus- carbachol in isolated guinea pig tra- U-46619, potentiation of vasopressor re- ceptibility of vasodilator nerve, en- chea are augmented by cooling and sponse, estradiol, lung (rats), 686 dothelium and smooth muscle func- inhibited by nifedipine, 755 U 50,488, modulation of discriminative tions to Ca1” antagonists in cerebral Tahara, T., see Nakajima, T., 730 stimulus effects, cocaine, mu and arteries, 234 Takada, K., Barrett, J. E., Allen, M.S., kappa opioids (monkeys), 607 Toluene, trichloroethylene and, sex-/age-/ Cook, J. M. and Katz, J. L.: Punish- Ueband, P. M., see Christensen, B., 1096 pregnancy-induced changes in me- ment of schedule-controlled behavior UK 14,304, opposite rank order of potency, tabohism, liver (rats), 869 with fl-carboline injections: Antago- water and solute excretion (rats), Tonini, M., see Rizzi, C. A., 412 nism and comparisons with other 1080 Torphy, T. J., see Zhou, H.-L., 1260 compounds, 138 Ulus, I. H., Buyukuysal, R. L. and Wurt- Toson, G., see Dal Forno, G., 1056 Takano, M., see Hori, R., 1200 man, R. J.: N-Methyl-D-aspartate in- Trachea Takano, Y. and Yaksh, T. L.: Characteriza- creases acetylcholine release from rat control of contractile response, histamine tion of the pharmacology of intrathe- striatum and cortex: Its effect is aug- N-methyltransferase (guinea pigs), cabby administered alpha-2 agonists mented by choline, 1122 1268 and antagonists in rats, 764 Urciuoli, M., see Dal Forno, G., 1056 inhibitory effects, cromakalim and BRL Takano-Ohmuro, H., see Hori, M., 506 Urinary bladder, blocking action of terodi- 38227 (guinea pigs, humans), 429 Takano-Ohmuro, H., see Sato, K., 497 line, calcium channels, single smooth phasic responses to carbachol, augmen- Takase, K., see Hikasa, Y., 746 muscle cells (guinea pigs), 724 tation by cooling, inhibition by nife- Takemura, M., see Ohrui, T., 1268 see dipine (guinea pigs), 755 Utterback, B. G., Jackson, C. V., 546 Takishima, T., see Ohrui, T., 1268 Tassin, J.-P., see Vezina, P., 484 relaxants, conversion to partial agonists, Vainio, H., see Nakajima, T., 869 Taylor, B., see Janowsky, A., 1282 beta-2 sympathomimetics (guinea Van Amsterdam, F. T. M., see Dal Forno, Taylor, J. F., see Taylor, S. G., 429 pigs), 258 G., 1056 Taylor, S. G., Arch, J. R. S., Bond, J., Buc- Trachealis, agonist-related differences in re- Van Bezooijen, C. F. A., see Stijnen, A. M., lationship, cAMP content and pro- kle, D. R., Shaw, D. J., Taylor, J. F. 81 and Ward, J. S.: The inhibitory ef- tein kinase activity (dogs), 1260 Van Dyke, R. W., Faber, E. D. and Meijer, Tramazoline, alpha adrenoceptor subtypes, fects of cromakalim and its active D. K. F.: Sequestration of organic emetic action (dogs), 746 enantiomer BRL 38227 against var- cations by acidified hepatic endocytic Triazolam ious agonists in guinea pig and hu- vesicles and implications for biliary benzodiazepine receptor occupancy man airways: Comparison with pin- excretion, 1 functional effects of ligands, differing acidib and verapamil, 429 Vanhoutte, P. M., see Schini, V. B., 553 intrinsic efficacies (mice), 1113 T cells, dual action of 2,3-butanedione mon- Van Nyen, G., see Van Wauwe, J., 773 GABA-stimulated chloride flux (rats), oxime, potassium current (humans), Van Wauwe, J., Van Nyen, G., Coene, M.- 1106 438 C., Stoppie, P., Cools, W., Goossens, Teeter, L. D., see Dutt, A., 1222 Trichboroethylene, toluene and, sex-/age-/ pregnancy-induced changes in me- J., Borghgraef, P. and Janssen, P. A. Tellez-I#{241}#{243}n,M. T., see Elgoyhen, A. B., 534 J.: Liarozole, an inhibitor of retinoic Teniposide, etoposide and, cytochrome P. tabolism, liver (rats), 869 acid metabolism, exerts retinoid-mi- 450 metabolism (humans), 491 2,4,5-Trihydroxymethamphetamine, 3,4- metic effects in vivo, 773 Terodiline, blocking action on calcium dihydroxymethamphetamine and, Vas deferens, models of peripheral sympa- channels, urinary bladder, single central serotonergic and dopami- thetic autoregulation, role of neu- smooth muscle cells (guinea pigs), nergic systems (rats), 447 ronal histamine (rats), 943 724 Trist, D., see Dab Forno, G., 1056 Vasoactive intestinal polypeptide, pharma- Tetrahydrocannabinol, varying content and Tryptophan hydroxylase, decrease in activ- number of puffs, marijuana smoking ity induced by methamphetamine, cologic characterization, muscularis (humans), 114 flunarizine and nimodipine effects mucosae, colon (rabbits), 1136 Thomas, G., Myers, A., Farhat, M., Cathap- (rats), 586 Vasoconstriction, angiotensin Il-mediated, ermal, S. and Ramwebl, P. W.: Effect Tseng, L. F., see Arts, K. S., 643 block by calcium antagonists (hu- of N-substituted arginine compounds Tseng, L. F. and Wang, Q.: Forebrain sites mans), 879 on blood pressure in anesthetized differentially sensitive to f3-endor- Vasoconstnictor agents, neuropeptide Y-in- rats, 875 phin and morphine for analgesia and duced potentiation, d-myo-inositol-1, Thor#{233}n,P., see Feng, Q. P., 1129 release of met-enkephalin in the pen- 2,6-trisphosphate effects (rats), 1147 Thrombosis tobarbital-anesthetized rat, 1028 Vasodilation, action of organic mononi- block of vascular and platelet 5-HT2 re- Tsuchiya, T., see Hori, M., 506 trates (rats), 692 1992 Index 1309

Vasopressin glycine-induced gbomerular hyperfil- Wu, P. H., see Mihic, S. J., 108 antagonist inhibition, clotting factor re- tration in conscious rats, 96 Wurtman, R. J., see Ubus, I. H., 1122 lease (monkeys), 462 Ward, J. S., see Taylor, S. 0., 429 Xylazine, alpha adrenoceptor subtypes, opposite rank order of potency, water and Watanabe, T., see Ohrui, T., 1268 emetic action (dogs), 746 solute excretion (rats), 1080 Weil, J. A., see Olsen, G. D., 420 pressor and renal vasoconstrictor effects, Weise, V. K., see Kvetnansky, R., 899 Y-27152, antihypertensive effects (rats, NGnitm.Larginine, sympathetic Westfalb, T. C., see McAuley, M. A., 863 dogs), 730 nervous system (rats), 240 Widness, J. A., Veng-Pedersen, P., Modi, N. Yabu, H., see Kura, H., 724 Vein, femoral, comparative antithrombotic B., Schmidt, R. L. and Chestnut, D. Yaksh, T. L., see Jang, J., 592 effects, heparmn/hirudin/argatroban H.: Developmental differences in Yaksh, T. L., see Takano, Y., 764 (hamster), 895 erythropoietin pharmacokinetics: In- Yamamoto, M., see Inui, K.-I., 195 Vemulapalli, S., see Chiu, P. J. S., 994 creased clearance and distribution in Yamanaka, T., see Nakajima, T., 730 Veng-Pedersen, P., see Widness, J. A., 977 fetal and neonatal sheep, 977 Yamano, M., see Miyata, K., 297 Ventral tegmental area, differential activa- Wiedemann, D. J., Garris, P. A., Near, J. A. Yamauchi, K., see Ohrui, T., 1268 tion of dopamine, nicotine and mor- and Wightman, R. M.: Effect of Yam, Q.-S., Mishra, P. K., Burger, R. L., phine, brain (rats), 484 chronic haloperidol treatment on Bettendorf, A. F., Jobe, P. C. and Verapamil stimulated synaptic overflow of do- Dailey, J. W.: Evidence that carbamazepine and antiepilepsinine block of angiotensin Il-mediated vasocon- pamine in the rat striatum, 574 may produce a component of their striction (humans), 879 Wightman, R. M., see Wiedemann, D. J., anticonvulsant effects by activating inhibitory effects, cromakabim and BRL 574 serotonergic neurons in genetically Wilkerson, R. D., see Foy, F. A., 601 38227, airways (guinea pigs, hu- epilepsy-prone rats, 652 mans), 429 Williams, J. T., see Harris, G. C., 476 Yaoka, 0., see Nakajima, T., 730 Williams, P. J., Dunwiddie, T. V. and Ger- Vezina, P., Blanc, G., Gbowinski, J. and Yasuhara, M., see Hori, R., 1200 Tassin, J.-P.: Nicotine and morphine hardt, 0. A.: Direct in vitro electro- YMO6O, role of serotonin3 receptor, stress- chemical measurement of dopamine differentially activate brain dopa- induced defecation (rats), 297 mine in prefrontocortical and subcor- overflow in intermediate pituitary: Yohimbine tical terminal fields: Effects of acute Characterization and pharmacology, alpha adrenoceptor subtypes, emetic ac- and repeated injections, 484 403 tion (dogs), 746 Villar, V. M., see Bhargava, H. N., 290, 1008 Wilson, H. C., see Cohen, M. L., 202 intrathecal administration, alpha-2 ago- Vogt, J., see Parsons, A. M., 1213 Wilson, H. C., see Jackson, C. V., 546 nists and antagonists (rats), 764 Volkensin, neocorticab pyramidal neurones, Windebank, A. J., see Brat, D. J., 803 Yoo, S. D., see McNamara, P. J., 918 5-HT1A receptors (rats), 1273 Winger, G., see Bertabmio, A. J., 278 Yoshikawa, T., see Pardridge, W. M., 1175 von Willebrand factor, release, inhibition, Winger, G., Skjoldager, P. and Woods, J. Yoshino, M., see Kura, H., 724 vasopressin antagonist (monkeys), H.: Effects of buprenorphine and Young, A. M., Masaki, M. A. and Geula, C.: 462 other opioid agonists and antagonists Discriminative stimulus effects of Vore, M., see Liu, Y., 560 on alfentanil- and cocaine-reinforced morphine: Effects of training dose on responding in rhesus monkeys, 311 agonist and antagonist effects of Mu Wada, H., see Ohrui, T., 1268 Winquist, R. J., see Li, T., 959 opioids, 246 Wallace, J. L., see Perretti, M., 1238 Wong, L. T. Y., Smyth, D. D. and Sitar, D. Yuki, H., see Miyata, K., 297 Wang, J. Q. and Ingenito, A. J.: Centrally S.: Interference with renal organic Zalups, R. K., see Lash, L. H., 819 mediated cardiovascular actions of (+)- cation transport by and (-)-nic- Zhang, X., see Allan, A. M., 395 dynorphin A(1-8) on rat hippocam- otine at concentrations documented Zhou, H.-L., Newsholme, S. J. and Torphy, pal formation, 678 in plasma of habitual tobacco smok- T. J.: Agonist-related differences in Wang, Q., see Tseng, L. F., 1028 ers, 21 the relationship between cAMP con- Wang, R.-S., see Nakajima, T., 869 Woods, J. H., see Bertalmio, A. J., 278 tent and protein kinase activity in Wang, Y.-X. and Brooks, D. P.: Renin-an- Woods, J. H., see Winger, G., 311 canine trachealis, 1260 giotensin system inhibition reduces Wu, E. Y., see Di Monte, D. A., 44 Zobrist, R., see Johnson, M., 586 nent OptiOnS: Lieck enclosed 0 Bill me SA 0 MasterCard 0 American Express

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