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Home , Quadazocine, Sarafotoxin

INDEX

Volume 271 , October-December 1994

A431 cells, PKC mediation of EGF-in- vascular subtypes, effects on electrical effects on hepatic portal pressure, pre- duced 12-lipoxygenase expression stimulation pressor response, in vention of, 20 in, 567 pithed rats, 748 effects on 5-HT3 receptors, 898 AA, see Arachidonic acid alpha-2 Alkaloids, intestinal brucine-binding sites, Abdel-Rahinan, A. A.: Acute effects of eth- antinociceptive effects against 1074 anol on cardiac output and ito do- inflammation, 1306 Alkondon, M., Reinhardt, S., Lobron, C., rivatives in spontaneously hyper- mediation of amitraz inhibition of in- Hermsen, B., Maelicke, A. and Al- tensive and normotensive rats, sulin release by, in rat beta cells, buquerque, E. X.: Diversity of mc- 1150 1240 otinic acetylcholine receptors in Abdominal aorta, up-regulation of angio- alpha-2A, species orthologs, bovine and rat hippocampal neurons. II. The tensin II receptors in, in rabbit, rat vs human and porcine, 735 rundown and inward rectification 1591 alpha-2B, precoupling with G-proteins, of agonist-elicited whole-cell cur- Abe, K., see Sugiura, M., 703 in PC12 cells, 1520 rents and identification of recep- Abelleira, S. M., see Doctrow, S. R., 229 alpha-2C, [3H]-MK912 selectivity for, tor subunits by in situ hybridiza- ABT-418, anxiolytic-like effects, 353 1558 tion, 494 Acetylcholine beta Alkylglycosides, absorption-enhancing ef- neonatal hypoxia-associated increase in, agomsts, suppressor effects of inhibi- fects on topical ocular , in 1299 tore of PDE IV interaction with, rat, 1274 release of 1167 Allen, H. M., see Robinson, S. E., 1234 in brain, effects ofNS-3 on, in rat, 884 -induced down-regulation, Allografts, cardiac, effects of liposomal from circular muscle nerves, inhibi- in rat brain, 1699 methylprednisolone on survival, tion by NO, in canine ileum, 918 modulation ofethanol by, in rat brain, in rats, 868 K, Cl and Na channel roles in li- 1175 Alonso, M. J., see Casado, M. A., 1638 nopirdine-induced enhancement Alprazolam, behavioral effects and abuse regulation of gap-junctional intercel- of, in rat, 891 liability in humans, comparison lular communication by, in rabbit Acetylcholine receptors, see Nicotinic re- with tandospirone, 683 gastric epithelial cells, 397 ceptors Amano, K.-I., Hori, M., Ozaki, H., Mat- signaling, effects of thyroid hormone Action potential duration, rate-dependent suda, Y. and Karaki, H.: Ca on, in developing rat brain, 472 prolongation by sematilide, in mobifization mediated by endo- beta-i, effects on antidepressant-like ef- guinea pig ventricular myocytes, thelin ETA receptor in endothe- 302 fects of isoproterenol, 246 hum of rabbit aortic valve, 1359 beta-2 Acute renal failure, effects of SB 209670 Amici, C., see Lacal, P. M., 1096 and BQ123 on, in anesthetized cardiac effects, in guinea pig, 386 Amine storage, cocaine effects on, in rat dogs, 769 effects on antidepressant-like effects and bovine, 1444 Acyl-tetragastrin, intestinal permeabffity, of isoproterenol, 246 r-Aminobutyric acid receptors, mediation in rats, 1509 beta-3, effects of cell type on desensiti- of PHDA neurons by, 1000 Adams, J., see Farina, P. R., 1418 zation of, 1253 y-Aminobutyric acidA receptors Adams, M. R., see Williams, J. K., 671 Adrenocorticotropic hormone antagonists, spinal, prevention of in- Adams, P., see Sullivan, J. P., 624 mediation by 5-HT receptors flammation-induced excitatory Adaniya, H., see Sawanobori, T., 302 differential receptor reserve for, 1246 amino acid release by, in rats, 76 Adenosine effects of prenatal cocaine exposure chloride flux induced by, effects of cyclo- Katp channel blockade effects on, 14 on, in male vs female rat progeny, dienes and hexachlorocyclohex- striatal, intrastriatal Ro15-4513 effects on 1453 anes on, in cortical neurons, 1616 modulation ofethanol-induced mo- mediation by 5-HT receptors, 1647 sensitivity to, during estrus cycle, 164 tor incoordination by, in rats, 524 Age, modulation of MDMA neurotoxicity 2-Aminochromones, U-86983, inhibition of Adenosine receptors by, 285 rat vascular smooth muscle cells A1, agonist cardiac effects, in guinea pig, AGM-1470, see TNP-470 by, 415 1371 Airways, NANC contractions of, effects of a-Amino-3-hydroxy-5-methyl-4-isox- agomsts, 1Ltp channel blockade effects PDE inhibitors on, in guinea pig, azolepropionate receptor antago- on, 14 811 fists, anticonvulsant activity, 25 mediation ofethanol-induced changes in Akerman, KE.0., see Wilkinson, A., 1314 (+)-N-(6-Amino-3-pyridil)-N’-[(1S,2R,4R)- NG1O8-15 cells by, 542 AL0671, effects on lipid metabolism in bicyclo-[2.2.1]hept-2-yl]-N”-cya- protection against METH-induced neu- obese Zucker rats, 1666 noguanidine hydrochloride, see rotoxicity by, 1320 Alaproclate, antagonism of NMDA recep- AL0671 Adenylate cyclase, effects of thyroid hor- tors by, 1314 Amitraz, inhibition of insulin release by, mone on, in developing rat brain, Albinsson, A., see Bj#{246}rk,A., 1338 in rat beta cells, 1240 472 Albuquerque, E. X, see Alkondon, M., 494 AMPA, see a-Amino-3-hydroxy-5-methyl- Adrenoceptors Albuterol, suppressor effects of inhibitors 4-isoxazolepropionate alpha, subtypes in human and canine of PDE N interaction with, 1167 d-Amphetamine sulfate, behavioral ef- prostate membranes, 1228 Alcohol, see also Ethanol fects, 638 alpha-i acute, increase in plasma ANP after, in Amygdala neurons, IL-113 effects in, 590 modulation ofl-type calcium channels rats, 1656 Analgesia, see also Antinociception by, in neonatal rat ventricular binge drinking, effects on ethanol on mu , role of CCK in delta agonist cells, 935 splenic NK cells in mouse model, facilitation of, 1127 intracellular mechanisms of, 944 722 , in rhesus monkeys, 993

1721 1722 Index Vol. 271

opioid chronic, effects on and c-fos Atrial natriuretic , plasma, acute effects on, 715 mRNA in rat neostriatal subre- alcohol effects on, in rats, 1656 effects of pharmacogenetics on, in gions, 460 Au, J.L.-S., see Gao, X., 818 Sprague-DawleyfDark Agouti rat, potential, ergoline derivatives, 343 Augustin, W., see SchrOder, U., 1193 1528 Antisense, D1, inhibition of D1 behaviors AU1akh, C. S., Mazzola-Pomietto, P., Hill, in vivo apparent pA analysis with by, in mice, 1462 J. L. and Murphy, D. L.: Role of for, in rats, 959 Anxiety, ABT-418 effects against, 353 various 5-HT receptor subtypes pharmacodynamic model of, 795 Aorta, ET contractions of, inhibition by in mediating neuroendocrine ef- fects of 1-(2,5-dimethoxy4-meth- sigma antagonism of, 1583 nickel, in rabbit, 1223 ylphenyl)-2-aminopropane spinal muscarimc, mediation by 1-argi- Aortic valve, endothelial ETA receptors in, (DOM) in rats, 143 nine/nitric oxide/cyclic GMP cas- in rabbit, 1359 Apamin, effects on NANC and NO donor Autacoids, production by furosemide, 1611 cade, 601 Autoreceptors Anaphylaxis, interactions between leuko- relaxations, in guinea pig tra- chea, 782 monoamine, cocaine effects on, in yen- trienes and histamine in, guinea tral tegmental area, in rats, 1597 pig lung parenchyma, 615 APD, see Action potential duration Arachidonic acid somatodendritic, systemic DA receptor Anders, M. W., see Fitzsimmons, M. E., blockade of, regulation ofDA neu- cerebral cascade, effects of MC1-186 on, 515 rons by, 1181 1624 Anderson, D. J., see McGuire, J. J., 708 epoxidation by P450 2C8 and P450 2C9, Bacchi, C. E., see Thummel, K E., 557 Anderson, D. J., see Sullivan, J. P, 624 1427 Bacon, E., see Silver, P. J., 1143 Anderson, D. W., see Argentieri, D. C., metabolism of, dual CO/5-LO inhibitors Bacon, L., see Broening, H. W., 285 1399 of, tepoxalin, 1399 Baggs, R. B., see Fitzsimmons, M. E., 515 Andersson, G., see Bj#{246}rk,A., 1338 release of, inhibition by BLRM 270, in Bakkum, E. A., see Rittenhouse, P. A., Andrade, R., see Torres, G. E., 255 human neutrophils, 1418 1647 Anesthetics, see also specific drugs Aravagiri, M., see Merchant, K M., 460 Bakshi, V. P., Swerdlow, N. R. and Geyer, effects on 5-HT3 receptors, 898 ARF, see Acute renal failure M. A.: Clozapine antagonizes local, ionization and adsorption in deter- Argentieri, D. C., Ritchie, D. M., Ferro, M. phencycidine-induced deficits in gent micelles, drug fluorescence P., Kirchner, T., Wachter, M. P., sensorimotor gating ofthe startle study of, 220 Anderson, D. W., Rosenthale, M. response, 787 Angiogenesis inhibitors, diaminoanthra- E. and Capetola, R. J.: Tepoxalin: Bali, J.-P., see Cuq, P., 149 quinones, 1027 A dual cyclooxygenase/5-lipoxy- Bannon, A. W., see Sullivan, J. P., 624 Angiotensin I receptors genase inhibitor of arachidomc Barnes, P. J., see Dent, G., 1167 mediation of vascular smooth muscle metabolism with potent anti-in- Barr, D. M., see Thummel, K E., 549, 557 cells by, in rat, 56 flainmatory activity and a favor- Barrios, V., see Li, Z., 1135 nonpeptide AT2 antagonist, N-glucu- able gastrointestinal proffle, 1399 Bast, A., see Voss, H.-P., 386 romdation by rat, monkey and l-Arginine/mtric oxide/cyclic GMP cas- Battaglia, G. and Cabrera, T. M.: Potenti- human hepatic microsomal frac- cede, mediation of spinal musca- ation of 5-HT1A receptor-medi- tions, 91 rinic analgesia by, 601 ated neuroendocrine responses in Angiotensin II Arleth, A. J., see Sung, C.-P., 429 male but not female rat progeny losartan blockade of, 804 Arnaudeau, S., see Lepretre, N., 1209 after prenatal cocaine: Evidence low concentration effects, unmasking by Arneric, S. P., see Brioni, J. D., 353 for gender differences, 1453 PD 121981 and CGP 42112, in Arneric S. P., see Sullivan, J. P., 624 Bauco P. and Wise, R. A.: Potentiation of rabbit abdominal aorta, 1591 Arrhythmias, ischemic and reperfusion, lateral hypothalamic and midline Angiotensin II receptors sotalol effects on, 184 mesencephalic brain stimulation AT1 Arthritis, kaolin and carrageenan model, reinforcement by nicotine: Exam- binding sites in human placentae, prevention by spinal GABAA re- ination of repeated treatment, 1007 ceptor antagonists, in rats, 76 294 nonpeptide antagonists, N-glucu- Articular chondrocyte flow cytometry, of Baudry, J. P., see Cussac, C., 1353 ronidation by rat, monkey and free radical production, effects of Baumann, M. H., Char, G. U., De Costa, B. human hepatic microsomal frac- fluoroquinolones on, 1544 R., Rice, K C. and Rothinan, R. tions, 91 Artymyshyn, R. P., see Filtz, T. M., 1574 B.: GBR12909 attenuates co- Asano, H., see Yamamoto, T., 156 caine-induced activation of me- up-regulation of, in rabbit abdominal Asaoka, Y., see Liu, Y.-W., 567 solimbic dopamine neurons in the aorta, 1591 Asplund, A., Grant, D. and Karlsson, rat, 1216 4-Anilidopiperidine , ef- J.O.G.: Manganese(II)-N,N’- BD1008, see N-[2-(3,4-Dichloro- fects, pharmacodynamic model of, dipyridoxylethylenediamine- phenyl)ethyl]-N-methyl-2-(1-pyr- 795 N,N’-diacetate-S,S’-bis(phos- rolidinyl)ethylamine Anion transport, multiple biliary systems, phate)- and Mn-Cl2-induced Beck, F. X., Ohno, A., Dorge, A. and in rats, 370 endothelium-dependent relax- Thurau, K: Loop diuretics affect Antigen-specific 1gM plaque-forming cell ation in bovine mesenteric arter- transcellular electrolyte trans- responses, sympathetic media- ies, 609 port in cells of the distal convo- tion of IL-2 effects on, 977 Asthma luted tubules, 403 Antinociception, see also Analgesia GPLP anaphylactic contractions due to, Beck, G., see Ohlstein, E. H., 762 capsaicin, mediation by SP N-terminal interactions between leuko- Behavior metabolites and NO, in adult trienes and histamine in, 615 DRL, effects of beta adrenoceptors on mouse, 1281 G-protein levels in, in antigen-chal- central isoproterenol effects on, against inflammation lenged guinea pigs, 1713 246 dexmedetomidine, 1306 Astolfi, M., see Maggi, C. A., 1489 effects of D1 and D2 dopamine receptors U-50,488H, 1306 AT, see Angiotensin on, 638 kappa-opioid agonist, in squirrel mon- Ataxia, ethanol, intrastriatal Ro15-4513 inhibition by D1 antisense, in mice, keys, 1501 effects on, in rats, 524 1462 nalbuphine, in rhesus monkeys, 993 Atchison, J. A., see Pillion, D. J., 1274 effects of tandospirone and alprazolam Antipsychotics, see also specific drugs Atkinson, A. J., Jr., see Dordal, M. S., 1286 on, in humans, 683 atypical, Fos immunohistochemistry a,rnATP, see aj3-Methylenadenosine-5’- measures of -precipitated opi- prediction of, 1058 triphosphate ate withdrawal, 1391 1994 Index 1723

Behavioral desensitization, with MCC-in- BMY14802, see a-(4-Fluorophenyl)-4-(5- Brioni, J. D., O’Neill, A., Kim, D.J.B., duced nAChR up-regulation, 651 fluoro-2-pyrimidinyl)-1-pipera- Buckley, M. J., Decker, M. W. Behavioral supersensitivity, haloperidol- zine butanol and Arneric, S. P.: Anxiolytic- induced, effects of GM1 on, in BNAG derivatives, see 06-Benzyl-N- like effects of the novel cholin- rats, 1193 acetylguanosine derivatives ergic channel activator ABT- Belardinelli, L., Lu, J., Dennis, D., Mar- Bochner, F., see Cleary, J., 1528 418, 353 tens, J. and Shryock, J. C.: The Bode, D. C., see Silver, P. J., 1143 Broemng, H. W., Bacon, L., Slikker, W., cardiac effects of a novel A1-aden- Bohmaker, K, see Meller, E., 1246 Jr.: Age modulates the long-term osine receptor agonist in guinea BoknIk, P., see Neumann, J., 535 but not the acute effects of the pig isolated heart, 1371 Bole-Vunduk, B., see Krisch, I., 343 serotonergic neurotoxicant 3,4- Bennett, B. M., see McGuire, J. J., 708 Bonhaus, D. W., Loury, D. N., Jakeman, L. methylenedioxymethamphet- Benzodiazepine receptors, partial ago- B., Hsu, S.A.O., To, Z. P., Leung, amine, 285 Bronchodilators, TA 2005, selectivity of, in fists, blood-brain barrier perme- E., Zeitung, K D., Eglen, R. M. guinea pig heart, 386 ability and in vivo activity, in and Wong, E.H.F.: [3HIRS-23597- Bronchus, NANC contractions of, effects of rats, 1197 190, a potent 5-hydroxy- tryptamine4 antagonist labels PDE inhibitors on, in guinea pig, Benzodiazepines, as oral reinforcers, in sigma-i but not sigma-2 binding 811 rhesus monkeys, 200 sites in guinea pig brain, 484 Brooks, D. P., see Nambi, P., 755 2,3-Benzodiazepines, 3-N-substituted, Bonin, P. D., see Erickson, L. A., 415 Brooks, D. P., DePalma, P. D., Gellai, M., non-NMDA receptor antagonism Bonmassar, E., see Lacal, P. M., 1086, Nambi, P., Ohistein, E. H., El- by, 25 1096 liott, J. D., Gleason, J. and Ruf- Benzoylecgnomne, maternal and fetal 1ev- Bonney, R. J., see Tramposch, K M., 852 fob, R. R., Jr.: Nonpeptide endo- els after acute maternal iv admin- Borgeat, P., see Farina, P. R., 1418 thelin receptor antagonists. III. istration of cocaine, in rat, 1234 Effect of SB 209670 and BQ123 Bourri#{233},M., see Perrier, L., 91 O6-Benzyl-N-acetylguanosine derivatives, on acute renal failure in anesthe- BQ123, effects on acute renal failure in enhancement of chioroethylnitro- tized dogs, 769 anesthetized dogs, 769 sourea antitumor effects by, in Brown, J. F., see Tepperman, B. L., 1477 Brackeen, M. F., see Lutz, M. W., 795 chioroethylnitrosourea-resistant Brucine, intestinal alkaloid-binding sites, Bradycardia, vagal, 5-HT agonist-in- human malignant melanocytes, 1074 duced, tolerance to, 776 1353 Brush-border membranes, cefadroxil/W- Bradykimn, effects on cytosolic calcium in Berger, Y., see Pearler, L., 91 symport systems in, in rat kid- rat myenteric neurons, 507 Bernardino, V., see Chintala, M. S., 1203 ney, 1327 receptors, B2 Beta cells, RINm5F rat line, amitraz inhi- BTS27271, inhibition ofinsulin release by, activation by RMP-7, in rat brain micro- bition of insulin release in, 1240 in rat beta cells, 1240 vascular endothelial cells, 229 Bhanot, S., see Verma, S., 1334 Buccafusco, J. J., see Yang, X, 651 effects on cytosolic calcium, in rat myen- Bhatt, R. K, see Wheelan, P., 1514 Buchholz, J. N., see Li, Z., 1135 teric neurons, 507 Bicuculline, spinal, prevention of inflam- Buchholz, R. A., see Silver, P. J., 1143 Brain mation-induced excitatory amino Buckley, M. J., see Brioni, J. D., 353 acetylcholine release in, effects of NS-3 acid release by, in rats, 76 Buckley, M. J., see Sullivan, J. P., 624 on, in rat, 884 Budihna, M. V., see Krisch, I., 343 Bienkowski, M. J., see MCCall, R. B., 875 beta receptor down-regulation in, imi- Bigelow, G. E., see Preston, K L., 48 Buerke, M., Weyrich, A. S., Murohara, T., pramine-induced, in rat, 1699 Biliary excretion, oforgamc anions, multi- Queen, C., Klingbeil, K, Co, M. S. beta receptor modulation of ethanol in, and Lefer, A. M.: Humanized ple systems for, in rats, 370 in rat, 1175 monoclonal antibody DREG-200 Biotta, J. M., see Lutz, M. W., 795 beta receptor signaling in, effects of thy- directed against 1-selectin pro- Binder, J., see Mishina, E. V., 868 roid hormone on, in developing tects in feline myocardial reperfu- Binge drinking, see also Alcohol; Ethanol rat, 472 sion injury, 134 effects on splenic NK cells, in mouse DA uptake into synaptic vesicles, inhi- Bufflngton, C.A.T., see Gao, X, 818 model, 722 bition by cocaine congeners, in , discriminative stimulus BIRM 270, inhibition of AA release by, in rat, 1444 and analgesic effects of, in vivo human neutrophils, 1418 maternal and fetal cocaine and benzo- apparent pA2 analysis with nal- Bj#{246}rk,A., Christensson, E., Albinsson, A., ylecgnonine levels, after acute trexone for, in rats, 959 Gustafsson, B., Pettersson, E., maternal iv cocaine, in rat, 1234 Burke, T. F., Woods, J. H., Lewis, J. W. Pettersson, G., Svartengren, J. microvascular endothelial cells in, and Medzihradsky, F.: Irrevers- and Andersson, G.: In the search RMP-7 effects on intracellular ible effects of for a novel class of antipsychotic free calcium levels in, in rat, 229 clocinnamox on opioid analgesia drugs: Preclinical pharmacology neonatal, diffusion of M6G into, during and mu receptor binding in mice, of FG5803, a 1-piperazinecarbox- drug-induced respiratory depres- 715 amide derivative, 1338 sion, in guinea pig, 118 Butanol, effects on 5-HT3 receptors, 898 Bladder, urinary, interstitial cystitis ef- nicotine stimulation reinforcement in, Butelman, E. R., see Gerak, L. R., 993 fect.s on drug absorption from, 294 Butkerait, P., Wang, H.-Y. and Fried- 818 man, E.: Increases in guanine mcotinic receptors in, sensitivity to, ef- Blood hormones, regulation by 5-HT re- nucleotide binding to striatal G fects of chronic nicotine and ceptors, differential receptor re- mecamylamine infusion on, 125 proteins is associated with dopa- serve for, 1246 binding in, in monkey, mine receptor supersensitivity, Blood prostaglandin endoperoxide syn- 1630 422 thases, human, characterization Branch, C. A. and Knuepfer, M. M.: , drug discrimination assess- of, 1705 Causes of differential cardiovas- ment of opioids in humans, 48 Bylund, D. B., see O’Rourke, M. F., 735 Blood-brain barrier, L-663,581 permeabil- cular sensitivity to cocaine II: ity, in rats, 1197 Sympathetic, metabolic and car- BMS181162 diac effects, 1103 Cabanne, S., see Defacque, H., 193 effects on leukotriene, prostaglandin Breese, G. R., see Duncan, G. E., 1699 Cabrera, T. M., see Battaglia, G., 1453 and PM’ biosynthesis, 852 Brem, S., see Takano, S., 1027 Calcitomn gene-related peptide, vascular topical anti-inflammatory effects, 852 Breuer, D. K, see Laneuville, 0., 927 contents, effects of chronic nico- BMS186295, see SR 47436 Brioni, J. D., see Sullivan, J. P., 624 tine on, in rats, 1135 1724 Index Vol. 271

Calcium Carrageenan model Charybdotoxin, effects on NANC and NO extracellular, in contractile effects of of arthritis, prevention by spinal donor relaxations, in guinea pig guinea pig tracheal 5-HT recep- GABAA receptor antagonists, in trachea, 782 tore, 832 rats, 76 Chaudhry, A. and Granneman, J. G.: In- intracellular of inflammation, antinociceptive effects fluence of cell type upon the de- bradykinin effects on, in rat myenteric of U-50,488H and dexmedetomi- sensitization of the (33-adrenergic neurons, 507 dine against, 1306 receptor, 1253 in contractile effects of tracheal Casado, M. A., Sevilla, M. A., Alonso, M. Chen, I.-W., see Lin, J. H., 1197 5-HT receptors, in guinea pig, J., Marin, J. and Salaices, M.: Chen, J., see Undem, B. J., 811 832 Muscarimc receptors involved in Chen, M.-F., see Williams, J. K, 671 mediation by endothelial ETA recep- modulation of norepinephrine re- Chen, N.-H. and Reith, M.E.A.: Autoregu- tors, in rabbit aortic valve, 1359 lease and vasodilatation in lation and monoamine interac- mediation by prostaglandins, 507 guinea pig carotid arteries, 1638 tions in the ventral tegmental NMDA receptor-induced increases in, Catalepsy, haloperidol-induced, dopamine area in the absence and presence steroid modulation of, 677 cell density and, 969 of cocaine: A microdialysis study in freely moving rats, 1597 picomolar PM’ effects on, 824 Catecholamines, effects in indomethacin- Chen, T.-H. and Hsu, W. H.: Inhibition of RMP-7 effects on, in rat brain micro- induced antral and corpus le- insulin release by a formamidine vascular endothelial cells, 229 sions, in rats, 695 pesticide an#{252}trazand its metabo- Calcium channels C-CAM, see Clocinnamox lites in a rat beta-cell line: An ac- elgodipine effects on, in portal vein myo- Cecum, circular smooth muscle cell mus- tion mediated by alpha-2 adreno- cytes, 1209 carinic receptor subtypes in, in ceptors, a GTP-binding protein ET effects on, inhibition by nickel, in rabbit, 149 and a decrease in cyclic AMP, rabbit aorta, 1223 Cefadroxil/W-symport systems, in kidney 1240 inhibition by isoflurane, in guinea pig brush-border membranes, in rat, Cheng, C.-P., Pettersson, K and Little, W. portal vein smooth muscle cells, 1327 C.: Effects of felodipine on left 1159 Central sympathoexcitation, mediation of ventricular systolic and diastolic L-type differential cardiovascular sensi- performance in congestive heart alpha-i adrenergic modulation of, in tivity to cocaine by, 1103 failure, 1409 neonatal rat ventricular cells, 935 Cerebellum, (3-adrenergic modulation of Chiba, K, see Koyama, E., 860 intracellular mechanisms of, 944 ethanol-induced depressions of Chien, C-C. and Pasternak, G. W.: Selec- blockade by Re 40-5967, 1483 Purkinje neurons in, in rat, 1175 tive antagonism of opioid analge- NMDA-mediated, effects of prenatal Cerebral cortex sia by a sigma system, 1583 ethanol exposure on, 1291 GABA-dependent chloride flux in, ef- Chilton, F. H., see Tramposch, K M., 852 T-type, blockade by Re 40-5967, 1483 fects of cyclodienes and hexachlo- Chinchilli, V. M., see Robinson, S. E., 1234 voltage-activated, effects of SR33557 rocyclohexanes on, 1616 Chinese hamster ovary cells, delta-opioid and SR33805 on, 1348 K Cl and Na channel roles in re- receptor density and activity in, Calyculin A, cardiac effects, 535 lease-enhancing effects of linopir- 1686 cAMP, see Cyclic AMP dine in, in rat, 891 Chintala, M. S., Bernardino, V. and Chiu, Cannabinoids, cross-tolerance between, nicotinic receptors P.J.S.: Cyclic GMP but not cyclic 1383 effects of chronic MCC on, 651 AMP prevents renal platelet ac- Capetola, R. J., see Argentieri, D. C., 1399 MCC-induced up-regulation of, 651 cumulation after isehemia-reper- Capsaicin, antinociceptive effects, media- NMDA currents in, nitrendipine reduc- fusion in anesthetized rats, 1203 tion by SP N-terminal metabo- tion of, in rodent, 30 Chiu, P.J.S, see Chintala, M. S., 1203 lites and NO, in adult mouse, NMDA-stimulated NO synthase in, eth- Chloride channels 1281 anol inhibition of, 67 effects on release enhancement by li- Carbon tetrachloride, hepatotoxic effects, Cerebrum nopirdine, in rat cerebral cortical methamphetamine potentiation arachidonate cascade in, effects of MC1- slices, 891 of, in mice, 1051 186 on, 1624 GABA-dependent, effects of cyclodienes 4(3’-Carboxyphenyl)-3,7-dimethyl- histamine H3 receptors in, [12511iodo- and hexachlorocyclohexanes on, 9(2”,6”,6”-trimethyl-1”- proxyfan antagonist binding to, in cortical neurons, 1616 cyclohexenyl),2Z,4E,6E,8E-nona- 452 14-(p-Chlorocinnamoylamino)-7,8-dihy- tetraenoic acid, see BMS-181162 c-fos mRNA dro-N-cyclopropylmethyl normor- phinone mesylate, see Clocin- Carcinosarcoma, Walker 256, in liver, an- effects of chronic antipsychotics on, in namox titumor effects ofMCT solution of rat neostriatal subregions, 460 7-Chioro-4,5-dihydro-5-methyl-3-(5-(1- TNP-470 via hepatic artery on, in protooncogene expression of, effects of methylethyl)-i,2,4-oxadiazol-3- rats with, 1267 thyroid hormone on, in develop- yl)6H-imidazo(i,5-A)(i.4)-benzo- Cardiac output, effects of ethanol on, in ing rat brain, 472 diazepine-6-one, see L-663,581 spontaneously hypertensive and CG-3703, see NS-3 Chloroethylnitrosourea, antitumor effects, normotensive rats, 1150 see Cyclic GMP cGMP, enhancement by BNAG, in chlo- Cardiorespiratory depression, 13-endor- 42112, unmasking of angiotensin II CGP roethylmtrosourea-resistant hu- phin-induced, Gly-l-Gin inhibi- low concentration effects by, in man malignant melanocytes, tion of, 952 rabbit abdominal aorta, 1591 1353 Cardiovascular system Chafetz, R., see Desai, S., 220 2-(4-Chlorophenyl)-i,1-dimethyl 2-amin- differential sensitivity to cocaine, causes Chakder, S., see Shibamoto, T., 277 opropanoate, see Alaproclate of, 1103 Chan, S., see Farrington, H., 1074 5-(4-Chlorophenyl)-N-hydroxy-(4-me- effects of on, in premenopausal Chandler, L. J., Guzman, N. J., Sumners, thoxyphenyl)-N-methyl-1H-pyra- monkeys, 671 C. and Crews, F. G.: Magnesium zole-3-propanamide, see Tepoxa- Carithers, R. L., Jr., see Thummel, K E., and zinc potentiate ethanol inhi- lin 549, 557 bition of N-methyl-D-aspartate- m-Chlorophenylpiperazine, 5-HT ago- Carlsson, A., see McCall, R. B., 875 stimulated nitric oxide synthase mst effects, 1122 Carnes, M., see Rittenhouse, P. A., 1647 in cortical neurons, 67 exo-2-(6-Chioro-3-pyridyl)-7-azabicyclo- Carotid artery, muscarinic receptors in, in Chang, W.-C., see Liu, Y.-W., 567 [2.2.i]heptane, see (±)-Epibati- guinea pig, 1638 Char, G. U., see Baumann, M. H., 1216 dine 1994 Index 1725

(R)-(-)-([1-(7-Chloro-4-quinolinyl)-5-(2,6- differential cardiovascular sensitivity phase III, -induced, inhibition by dimethoxyphenyl)pyrazol-3- to, causes of, 1103 , in Heidenhain yl)carbonylamino]cyclohexyl- effects on amine storage, in rat and bo- pouch dogs, 1471 acetic acid, see SR 49711 vine, 1444 Convulsants, sensitivity to, during estrus (S)-(+)-([1-(7-Chloro-4-quinolinyl)-5-(2,6- effects on dopamine, antagonism by cycle, 164 dimethoxyphenyl)pyrazol-3-yl) GBR12909, in rat, 1216 Corcoran, G. B., see Kamendulis, L. M., carbonylamino]cyclohexylacetic effects on 5-HT3 receptors, in rat nodose 1695 acid, see SR 48527 ganglion neurons, 262 Coronary artery 2-[1-(7-Chloro-4-quinolinyl)-5-(2,6-dime- effects on 5-HT-induced inward current NS-004 modulation of smooth muscle thoxyphenyl)pyrazol-3-yl)carbon- in rat nodose ganglion neurons, cell potassium currents in, in ca- ylamino]tricyclo(3.3. 1. 1.)- 262 nine, 362 decan-2-carboxylic acid, see SR effects on monoamine interactions in potassium channel blockade effects on 48692 ventral tegmental area, in rats, adenosine receptor agonist vaso- Chiorpromazine, inhibition ofK channels 1597 dilation of, 14 by, in rat ventricular myocytes, modulation of mesangial cells by, 311 Corpus lesions, indomethacin-induced, 632 overdose, cocaine binding sites on dopa- sympathetic nerve effects in, in CHO cells, see Chinese hamster ovary cells mine transporter in, 1678 rats, 695 Choi, M., see Gillis, A. M., 176 prenatal exposure, effects on 5-HT1 re- Corpus striatum Cholecystokimn, role in mu/delta interac- ceptors, in male vs female rat intrastriatal Roi5-4513 effects on ad- tions, 1127 progeny, 1453 enosinergic modulation of etha- Chondrotoxicity, fluoroquinolone, in vitro, Cocaine abuse, see also Drug abuse nol-induced motor incoordination 1544 maternal, maternal and fetal levels af- in, in rats, 524 Christensson, E., see Bj#{246}rk,A., 1338 tar, in rat, 1234 sigma receptor ligand regulation of do- Chromaffin cells, NPY inhibition of nico- Cocaine congeners, inhibition of DA up- pamine release from, in rat, 212 tinic receptor-mediated secretion take by, structure-activity rela- Corticosterone, mediation by 5-HT re- from, 61 tionships for, in rat brain synap- ceptors Chromaffin granules, DA uptake into, in- tic vesicles and bovine chromaffin differential receptor reserve for, 1246 hibition by cocaine congeners, in granules, 1444 effects of prenatal cocaine exposure on, bovine, 1444 , analgesic effects, effects of phar- in male vs female rat progeny, Chronic myelogenous leukemia, cloning macogenetics on, in Sprague- 1453 ‘FXA2 receptors from human DawleyfDark Agouti rat, 1528 Courtney, M., see Wilkinson, A., 1314 K562 cells, 1034 Coffey, L. L., see Reith, M.E.A., 1444 Cox, D. A., see Watts, S. W., 832 Chu, H., see Grotewiel, M. S., 1122 Cohen, M. L., see Watts, S. W., 832 CP 55,940, cross-tolerance with 9-THC Cipollone, F., see Patrignam, P., 1705 Coleman, R. A., see Smith, G.C.S., 390 Circular muscle nerves, NO inhibition of and WIN 55,212, 1383 Colitis, chronic granulomatous, nitric ox- acetylcholine release from, in ca- Cr#{233}minon,C., see Patrignani, P., 1705 ide effects on, 1114 nine ileum, 918 Cremophor Collins, A. C., Luo, Y., Selvaag, S. and Circular smooth muscle cells, cecum, mus- mediation of CsA vasoconstriction by, Marks, M. J.: Sensitivity to nico- carinic receptor subtypes in, in 730 tine and brain mcotimc receptors rabbit, 149 vascular effects of, inhibition by ifetro- are altered by chronic nicotine Circulating , over-expres- ban, 730 and mecamylamine infusion, 125 sion ofCYP2C11 by MSG with, in Crews, F. G., see Chandler, L. J., 67 Colon adult male rats, 1067 Crocetin di-gentiobiose ester, see Crocin activation by substance P, in rats, 7 Cl-977, antinociceptive effects, in squirrel Crocin, effects on hippocampal LW-block- inflammation of, nitric oxide effects on, monkeys, 1501 ing effect of ethanol, 703 with chronic granulomatous coli- Clarkson, C. W., see Xu, Y.-Q., 319 Cromakalim, vasorelaxant effects of, ef- Cleary, J., Mikus, G., Somogyi, A. and tis, 1114 mucosal histamine receptor subtypes in, fects of in vitro hypoxia on, in rat Bochner, F.: The influence of pulmonary arteries, 845 in canine, 1016 pharmacogenetics on opioid anal- Cross-tolerance, cannabinoid, 1383 neurotensin receptors in, in guinea pig, gesia: Studies with codeine and Crumb, W. J., Jr., see Xu, Y.-Q., 319 267 in the Sprague-Daw- Crutchley, D. J., Conanan, L. B. and Que, nitric oxide synthase in, effect of endo- leyfDark Agouti rat model, 1528 B. G.: Effects of prostacyclin ana- toxin challenge on, in rat epithe- Clement, M. E., see McCall, R. B., 776 logs on the synthesis of tissue fac- Clocinnamox, effects on mu receptor bind- hal cells, 1477 tar, tumor necrosis factor-a and ing and analgesia, 715 Commes, T., see Defacque, H., 193 interleukin-1 in human mono- Cloned 5-HT2A receptors, expressed in fi- Compton, D. R., see Fan, F., 1383 cytic THP-1 cells, 446 broblasts, mCPP and TFMPP Conanan, L. B., see Crutchley, D. J.,446 CsA, see Cyclosporine A , 1122 Conanan, N. D., see Ellis, J. L., 782 Cuq, P., Magous, R. and Bali, J.-P.: Phar- Cloning, of TXA receptors from K562 Congestive heart failure, effects of felodip- macological coupling and func- cells, 1034 me in, 1409 tional role for the muscarimc re- Clozapine Contractions, see also Vasoconstriction chronic, effects on neurotensin and c-los anaphylactic, interactions between leu- ceptor subtypes in isolated cells mRNA, in rat neostriatal subre- kotrienes and histamine in, in from the circular smooth muscle of the rabbit cecum, 149 gions, 460 guinea pig lung parenchyma, 615 effects on PCP-induced deficits in senso- , inhibition by nickel, in rab- Curry, L. A., see Doctrow, S. R., 229 rimotor gating of startle re- bit aorta, 1223 Cussac, C., Rapp, M., Mounetou, E., sponse, 787 leycromakalim effects on, in rat pulmo- Madelmont, J. C., Maurizis, J. C., Co, M. S., see Buerke, M., 134 nary artery, 326 Godeneche, D., Dupuy, J. M., Cocaethylene, cardiac sodium channel M2-induced, inhibition by pertussis Sauzieres, J., Baudry, J. P. and block by, 319 toxin, in guinea pig ileum, 1042 Veyre, A.: Enhancement of O6 Cocaine naloxone-induced, after preincubation benzyl-N-acetylguanosine deriva- acute maternal iv, maternal and fetal with , NMDA receptors tives of chloroethylmtrosourea levels after, in rat, 1234 in, in guinea pig ileum, 1365 antitumor action in chloroeth- binding sites on dopamine transporter NANC, effects of PDE inhibitors on, in ylmtrosourea-resistant human in cocaine overdose, 1678 guinea pig airways, 811 malignant melanocytes, 1353 1726 Index Vol. 271

(+)-R-2-Cyano-N,N-dipropyl-8-aino- sourea-resistant human malig- Deth, R. C., see Shi, A.-G., 1520 6,7,8,9-tetrahydro-3H-benilelin- nant melanocytes, 1353 Dewitt, D. L., see Laneuville, 0., 927 dole, see U-92016A dimethylnitrosamine, enhancement by Dexmedetomidine, antinociceptive effects Cyclic AMP DNA repair inhibitors, 1695 against inflammation, 1306 ethanol effects on, mediation by adeno- Diaminoanthraquinones, angiogenesis in- Dahl#{233}n,S.-E., see Jonsson, W., 615 hibitors, 1027 sine receptors, in NG1O8-cells, Daikh, B. E., Lasker, J. M., Raucy, J. L. Diamond, I., see Sapru, M. K, 542 542 and Koop, D. R.: Regio- and ste- isoproterenol effects on, in rabbit gastric reoselective epoxidation of Diarrhea, 5-HTP-induced, 5-liT effects in, epithelial cells, 397 arachidomc acid by human cyto- in mice, 741 M2 effects on, inhibition by pertussis chromes P450 2C8 and 2C9, 1427 Diaz, J., see Ligneau, X., 452 toxin, in guinea pig, 1042 Dams, K, see Hitzemann, B., 969 Diazepam, self-administration, in rhesus mediation of amitraz inhibition of insu- Dalga, R. J., see Erickson, L. A., 415 monkeys, 200 lin release by, in rat beta cells, D’Angelo, D. D., Davis, M. G., Ali, S and N-[2-(3,4-Dichlorophenyl)ethyl]-N-meth- 1240 Dorn, G. W., H: Cloning and phar- yl-2-[i-pyrimidinyl-1-piperazine PDE N inhibitor effects on, 1167 macologic characterization of a butanol], regulation of dopamine Cyclic GMP thromboxane A receptor from release from rat striatum by, 212 antiplatelet effects in ischemia-reperfu- K562 (human chronic myeloge- N-[2-(3,4-Dichlorophenyl)ethyl]-N-meth- sion injury, in rats, 1203 nous leukemia) cells, 1034 yl-2-(1-pyrrolidinyl)ethylamine, heart, HO-i regulation of, 408 Daniel, E. E., see Parrish, M. B., 39 regulation of dopamine release mediation of spinal muscarinic analge- Daniel, H., see Ries, M., 1327 from rat striatum by, 212 sia by, 601 Dar, M. S., see Meng, Z.-H., 524 5,6-Dichloro-4-thia-5-hexenoic acid, neph- nitric oxide synthase levels, effect of en- Darling, I. M., see Tramposch, K M., 852 rotoxicity and hepatotoxicity of, dotoxin challenge on, in rat co- Davern, L. B., see Tramposch, K M., 852 515 lonic epithelial cells, 1477 DCTH, see 5,6-Dichloro-4-thia-5-hexenoic Diclofenac, inhibition of hPGHS-i and -2 potentiation by WIN 58237, 1143 acid by, 927 Cyclic 3’:5’-guanosine monophosphate, see De Costa, B. see Baumann, M. H., 1216 9,10-Didehydro-N-methyl-N-(2-propynyl)- Cyclic GMP Decker, M. W., see Brioni, J. D., 353 2-bromo-6-methylergoline-813- Cyclodienes, effects on GABA-dependent Decker, M. W., see Sullivan, J. P., 624 carboxamide, see LEK-884i chloride flux, in cortical neurons, Deep muscular nerve plexus, NO inhibi- 9,10-Didehydro-N-methyl-N-(2-propynyl)- 1616 tion of acetylcholine release from, 6-methyl-8-aminomethylergo- N6-Cyclohexyl-2-O-methyladenosine, see in canine ileum, 918 line, see LEK-8829 SDZ WAG-994 Defacque, H., Demand, J., Commes, T., Dietary fat, effects on pharmacodynamics Sevilla, C. (S)-N-[2-Cyclohexyl-1-(2-pyridinyl)- Cabanne, S., and of quinidine, procainamide and ethyl]5-methyl-2-benzoxazo- Marti, J.: Different combinations tocaiide in rabbit hearts, 176 of retinoids and vitamin D3 ana- lamine, see BIRM 270 i-[3-(Diethylamino)-2-hydroxypro- logs efficiently promote growth Cyclooxygenasei5-lipoxygenase inhibitors, pyl]amino-4-[(2,3-epoxypro- inhibition and differentiation of tepoxalin, 1399 pyl)amino]-9,iO-anthracenedione myelomonocytic leukemia cell Cyclooxygenases, inhibition by NSAIDs, fumaric acid salt, see NSC 639366 lines, 193 927 Differential sensitivity, cardiovascular, to de Garavilla, L., see Silver, P. J., 1143 Cyclopentenone prostaglandins cocaine, causes of, 1103 Del Valle, J., see Gelperin, D., 507 effects on myeloid cells during early Differential-reinforcement-of-low-re- DelGrande, D., see Shetty, S. S., 1223 HTLV-I infection, 1086, 1096 sponse-rate behavior, effects of Delle Donne, K T. and Sonsalla, P. K: beta regulation of HSP7O by, 1096 Protection against methamphet- central isoproterenol on, ad- 1-Cyclopentyl-3-methyl-6-(4-pyridyl)pyra- amine-induced neurotoxicity to renoceptor effects on, 246 zolo[3,4-d]pyrimidin-4-(5H)-one, neostriatal dopaminergic neurons 2,3-Dihydro-7-hydroxy-2-(4-hydroxyphe- see WIN 58237 by adenosine receptor activation, nyl)-(S)-4H-i-benzopyran-4-i, (1-(Cyclopropylmethyl)-4-2’4”-fluorophe- 1320 see Liquiritigenin nyl)-(2’-oxoethyl)piperidine HBr, Dennis, D., see Belardinelli, L., 1371 i,4-Dihydropyridine, reduction of NMDA regulation of dopamine release Dent, G., Giembycz, M. A., Evans, P. M., currents by, in rodent cortical from rat striatum by, 212 Rabe, K F. and Barnes, P. J.: neurons, 30 Cyclosporine A, vasoconstrictor effects of, Suppression of human eosinophil la,25-Dihydroxyvitamin D3, effects on mediation by cremophor, 730 respiratory burst and cyclic AMP myeloid cells, comparison with CYP, see Cytochrome P450 hydrolysis by inhibitors oftype N retinoid effects, 193 Cystitis, interstitial, effects on drug ab- phosphodiesterase interaction Dilator prostaglandin receptors, in fetal sorption from urinary bladder, with the beta adrenoceptor ago- rabbit ductus arteriosus, 390 818 nist albuterol, 1167 i-(2,5-Dimethoxy-4-methylphenyl)-2- Cytochrome P450 Dentate gyrus, LW-blocking effect of eth- aminopropane, neuroendocrine 2C8, epoxidation of arachidomc acid by, anol in, effects of crocin on, 703 effects of, 5-HT receptor subtype 1427 DePalma, P. D., see Brooks, D. P., 769 roles in, in rats, 143 2C9, epoxidation of arachidomc acid by, Desai, S., Hadlock, T, Messam, C., Dimethylnitrosamine, cytotoxicity, en- in human, 1427 Chafetz, R. and Strichartz, G.: hancement by DNA repair inhib- 2Cii, over-expression by MSG, in adult Ionization and adsorption of a so- itors, 1695 male rats, 1067 ries of local anesthetics in deter- N’-2,4(Dimethylphenyl)-N-[((2,4-dimeth- 2Di, mediation ofopioid analgesia by, in gent micelles: Studies ofdrug flu- ylphenyl)imino)methyl]-N- Sprague-Dawley/Dark Agouti rat, orescence, 220 methanimidamine, see Amitraz 1528 Deschaintres, S., see Labbd-Julli#{233}, C., 267 N’-(2,4-Dimethylphenyl)-N-methylforma- 3A4, hepatic variability after liver Desensitization midine, see BTS27271 transplantation, midazolam char- of 133 receptor, effects of cell type on, (25,i2bS,)i’,3’Dimethylspiro(1,3,4,5’,6,6’, acterization of, in human, 557 1253 7 , 12b-octahydro-2H-benzo(b) male-specific form, hepatic, over-expres- behavioral, with MCC-induced nAChR furo(2,3-a)quinazoline)-2,4’-pyri- sion by MSG, in adult rats, 1067 up-regulation, 651 midin-2’-one, see [3H]-MK912 Cytotoxicity Detergent micelles, ionization and adsorp- Dinallo, R. M., see Farina, P. R., 1418 chloroethylmtrosourea, enhancement tion of local anesthetics in, drug Diphenyleneiodomum sulfate, inhibition by BNAG, in chloroethylnitro- fluorescence study of, 220 of glyceryl trinitrate by, 708 1994 Index I 727

Discriminative stimulus, agonist, Dopaminergic neurons Ebselen, vasodilative effect on hepatic vas- in vivo apparent pA2 analysis mesolimbic, GBR12909 antagonist of co- culature, 20 with naltrexone for, in rats, 959 caine effects on, in rat, 1216 Echizen, H., see Koyama, E., 860 Distal convoluted tubule cells, loop di- neostriatal, adenosine protection Eda, M., see Matzno, S., 1666 uretic effects on, 403 against METH-induced neurotox- Egawa, M., see Watanabe, T., 1624 DNA repair inhibitors, enhancement of icity to, 1320 EGF, see Epidermal growth factor dimethylnitrosamine cytotoxicity periventricular-hypophysial, GABA re- Eglen, R. M., see Bonhaus, D. W., 484 by, 1695 ceptor mediation of, 1000 Eglen, R. M., see Hegde, S. S.,74i Dobie, D. J., see Merchant, K M., 460 regulation by systemic DA antagonists, Ehlert, F. J., see Thomas, E. A., 1042 Doctrow, S. R., Abelleira, S. M., Curry, L. 1181 Elder, M. G., see Knock, G. A., 1007 A., Heller-Harrison, R., Kozarich, Dordal, M. S., Jackson-Stone, M., Ho, A. Electrical stimulation J. W., Malfroy, B., McCarroll, L. C., Winter, J. N. and Atkinson, A. hypogastric nerve, effects in internal A., Morgan, K G., Morrow, A. R., J., Jr.: Decreased intracellular anal sphincter, in opossum, 277 Musso, G. F., Smart, J. L, compartmentalization of doxoru- NANC contractile effects of, inhibition Straub, J. A., Turnbull, B. and bicin in cell lines expressing P- by PDE inhibitors, in guinea pig Gloff, C. A.: The bradykinin ana- glycoprotein, 1286 bronchus, 811 log RMP-7 increases intracellular Dorge, A., see Beck, F. X., 403 spinal, presser response to, effects of free calcium levels in rat brain Demand, J., see Defacque, H., 193 vascular alpha-i adrenoceptors microvascular endothelial cells, Dorsa, D. M., see Merchant, K M., 460 on, in pithed rats, 748 229 Douglas, S. A., see Ohlstein, E. H., 762 Electrolyte transport, transcellular, loop DOM, see i-(2,5-Dimethoxy-4-methylphe- Doxorubicin, compartmentalization in diuretic effects on, in distal con- nyl)-2-aminopropane cells expressing P-glycoprotein, voluted tubule cells, 403 Domarle, 0., see Thuong-Guyot, M., 1544 1286 Electrophysiology, in vivo study of seroto- Dominice, C., Dufour, M.-N., Patino, N., Drack E., see Scheurer, U., 7 nin-dopamine interaction in rat Manzom, 0., Grazzini, E., Jouin, DREG-200 (mAb), humanized, cardiopro- ventral tegmental area, 83 P. and Guillon, G.: Dual effects of tective effects in feline myocar- Elgodipine, effects on calcium channels nordidemnin on WRK1 cells: Inhi- dial reperfusion injury, 134 and radioligand binding, in portal bition of phosphoinositide metab- Drinking, see also Alcohol; Ethanol vein myocytes, 1209 olism and cell proliferation, 107 binge, effects on ethanol on splemc NK Elliott, J. D., see Brooks, D. P., 769 Donevan, S. D., Yamaguchi, 5.-I. and Re- cells in mouse model, 722 Elliott, J. D., see Nambi, P., 755 gawski, M. A.: Non-N-methyl-D- DRL behavior, see Differential-reinforce- Elliott, J. D., see Ohistein, E. H., 762 ment-of-low-response-rate behav- aspartate receptor antagonism by Ellis, J. L. and Conanan, N. D.: Effect of 3-N-substituted 2,3-benzodiaz- ior potassium channel blockers on re- epines: Relationship to anticon- Drug absorption, from urinary bladder, in- laxations to a nitric oxide donor vulsant activity, 25 terstitial cystitis effects on, 818 and to nonadrenergic nerve stim- Donnell, D., see Voss, H.-P., 386 Drug abuse, see also Cocaine abuse ulation in guinea pig trachea, 782 Donnelly-Roberts, D., see Sullivan, J. P., liability oftandospirone and alprazolam Elshourbagy, N., see Nambi, P., 755 624 for, in humans, 683 EM574, motilin agonistic profile, in hu- D’Onofrio, C., see Lacal, P. M., 1086, 1096 Drug discrimination, opiate agonist stim- man gastric antrum, 574 Dopamine ulus effects, in vivo apparent pA Emmerson, P. J., Liu, M.-R., Woods, J. H. cell density, and haloperidol-induced analysis with naltrexone for, in and Medzihradsky, F.: Binding catalepsy, 969 rats, 959 affinity and selectivity of opioids cocaine congener inhibition of, in rat Drug discrimination assessment, of opi- at mu, delta and kappa opioid re- brain synaptic vesicles and be- oids in humans, three-choice sa- ceptors in monkey brain mem- line--butorphanol vine chromaffin granules, 1444 branes, 1630 cocaine effects on, antagonism by procedure, 48 Endocytosis, pathophysiology of, in opos- GBR129O9, in rat, 1216 Drug fluorescence, study of ionization and sum kidney cells, 1 effects on polydipsia, 638 adsorption of local anesthetics in Endoperoxide synthases, human blood interaction with serotonin in ventral detergent micelles, 220 prostaglandin, characterization tegmental area, electrophysi- Drug-induced respiratory depression, dif- of, 1705 ological study in vivo of, in rat, 83 fusion of M6G into neonatal 3-Endorphin-induced cardiorespiratory neonatal hypoxia-associated increase in, guinea pig brain during, 118 depression, Gly-l-Gin inhibition 1299 Drugs, see specific drugs and drug types of, 952 striatal release, regulation by sigma re- Dual cyclooxygenase/5-lipoxygenase in- Endothelial cells ceptor ligands, in rat, 212 hibitors, tepoxalin, 1399 ETA receptors in, in rabbit aortic valve, supersensitivity to, effects ofGM1 on, in Duckles, S. P., see Li, Z., 1135 1359 rats, 1193 Ductus arteriosus, fetal, dilator prostan- microvascular, RMP-7 effects on intra- oid receptors in, in rabbit, 390 Dopainine receptors cellular free calcium levels in, in D1 Dufour, M.-N., see Dominice, C., 107 rat brain, 229 agonist and antagonist behavioral ef- Duncan, G. E., Knapp, D. J., Little, K. Y. Endothelial kiins, release of, enhance- fects, 638 and Breese, G. R.: Neuroanatomi- ment by furosemide, 1611 agonist modulation of basal ganglia cal specificity and dose depen- Endothelin-i output by, in rats, 1434 dence in the time course of imi- binding to human ETA and ETB recep- pramine-induced beta adrenergic antisense inhibition of D1 behaviors, tors, SB 209670 effects on, 755 receptor down-regulation in rat in mice, 1462 inhibition by nickel, in rabbit aorta, D2, agonist and antagonist behavioral brain, 1699 1223 effects, 638 Dundore, R. L., see Silver, P. J., 1143 Endothelin, mediation by AT1 receptors, D21, up-regulation mechanisms, in DuP 734, see (1-(Cyclopropylmethyl)-4- in rat vascular smooth muscle, transfected HEK-293 cells, 1574 2’4”-fluorophenyl)-(2’-oxoeth- 429 supersensitivity to, G protein effects in, yl)pipericline HBr Endothelin receptors, nonpeptide antago- 422 DuP 996, see Linopirdine nists systemic antagonists, regulation of DA Dupuy, J. M., see Cussac, C., 1353 effects on acute renal failure in anesthe- Dykstra, L. A., see Pitts, R. C., neurons by, 1181 1501 tized dogs, 769 Dopamine transporter, cocaine binding effects on ET-i binding to human ETA sites on, in cocaine overdose, 1678 Ebisu, H., see Matzno, S., 1666 and ETB receptors, 755 1728 Index Vol. 271

pharmacological characterization of, effects on LTB4 metabolism in, in rat Fat, dietary, effects on pharmacodynamics 762 hepatocytes, i5i4 of quiidine, procainamide and EndothelinA receptors hippocampal LW-blocking effect of, ef- tocainide in rabbit hearts, i76 effects on spinal nociception, i56 fects of crocin on, 703 Fatal cocaine overdose, binding sites on endothelial, in rabbit aortic valve, i359 inhibition of glutamate by, in nucleus dopamine transporter in, i678 human, SB 209670 effects on ET-i bind- accumbens, i566 Fatty acid beta-oxidation system, mite- ing to, 755 inhibition ofNMDA-stimulated NO syn- chondrial, bioactivation of DCTH EndothelinB receptors thase in cortical neurons by, 67 by, 515 effects on spinal nociception, i56 prenatal exposure, effects on NMDA- Feldman, P. L., see Lutz, M. W., 795 human, SB 209670 effects on ET-i bind- mediated calcium entry, i29i Felodipine, effects on left ventricular per- ing to, 755 Ethanol ataxia, intrastriatal RoiS-45i3 formance in CHF, i409 Endothelium-dependent relaxation, Mn- effects on, in rats, 524 , discriminative stimulus and an- DPDP- and Mn-Cl2-induced, in , discriminative stimulus and algesic effects of, in vivo apparent bovine mesenteric arteries, 609 analgesic effects of, in vivo appar- pA2 analysis with naltrexone for, Endotoxin challenge, effect on colonic m- ent pA analysis with naltrexone in rats, 959 tric oxide synthase, in rat epithe- for, in rats, 959 Ferrier, G. R., see Pasnani, J. S., 184 hal cells, i477 Evans, C., see Law, P. Y., i686 Ferro, M. P., see Argentieri, D. C., 1399 Endotoxin shock, protective effects of Evans, P. M., see Dent, G., ii67 Fetal ductus arteriosus, dilator prostanoid U-74006F against, in rats, 438 Evans, S. M., Troisi, J. R., II and Griffiths, receptors in, in rabbit, 390 Enters, E. K, see Robinson, S. E., i234 R. R.: Tandospirone and alprazo- Fetus, cocaine and benzoylecgnonine 1ev- Eosinophil respiratory burst, PDE N in- lam: Comparison ofbehavioral ef- els, after acute maternal iv ad- hibitor effects on, in human, ii67 fects and abuse liability in hu- ministration of cocaine, in rat, (± )-Epibatidine, biological effects medi- mans, 683 i234 Ewing, J. F., Raju, W. S. and Maines, M. ated by nAChRs, 624 Feuerstein, G., see Ohlstein, E. H., 762 D.: Induction of heart heme oxy- Epidermal growth factor, induction of i2- FG8205, see L-663,58i genase-i (HSP32) by hyperther- lipoxygenase expression by, medi- FG5803, preclinical pharmacology, 1338 mia: Possible role in stress-medi- ation by PKC, in A43i cells, 567 Fibiger, H. C., see Robertson, G. S., i058 ated elevation of cyclic 3’:5’- Epithelial cells Fibroblasts, cloned 5-HT receptors ex- guanosine monophosphate, 408 colonic, nitric oxide synthase in, effect of Excitatory amino acids, inflammation-in- pressed in, mCPP and TFMPP endotoxin challenge on, in rat, agonists, 1122 duced release of, prevention by i477 Filloux, F. M., see Merchant, K M., 460 gastric, gap-junctional intercellular spinal GABAA receptor antago- fists, fl rats, 76 Filtz, T. M., Guan, W., Artymyshyn, R. P., communication in, beta-adrener- Extracellular calcium, in contractile ef- Pacheco, M., Ford, C. and Molin- gic regulation of, in rabbit, 397 off, P. B.: Mechanisms of up-reg- intestinal, strychnine-binding proteins fects of guinea pig tracheal 5-HT2A receptors, 832 ulation ofD21 dopamine receptors in, 1074 by agomsts and antagonists in Epoxidation, of arachidonic acid, by P450 Extrapyramidal side effects, liability of transfected HEK-293 cells, i574 2C8 and 2C9, i427 antipsychotics for, Fos immune- histochemistry determination of, Fink, E., see Wiemer, G., i6ii Ergoline derivatives, potential antipsy- Fink, G. D., see Gorbea-Oppliger, V. J., 804 chotics, 343 i058 Finn, D. A. and Gee, K W.: The estrus Erickson, L. A., Bonin, P. D., Wishka, D. Eyedrops, insulin, absorption-enhancing cycle, sensitivity to convulsants G., Morris, J., Dalga, R. J., Wil- effects of alkylglycosides on, in and the anticonvulsant effect of a hams, D. J., Wilson, G. J., rat, i274 Hoover, J. L., Simmons, C. A., neuroactive steroid, 164 Humphrey, S. J. and Shebuski, R. F3, see i,2,2-Trifluorocyclobutane Fischer, J. B., see Kirk, C. J., 1080 J.: In vitro and in vivo inhibition Fabre, G., see Perrier, L., 9i Fisher, M. A., see Liu, P., 438 ofrat vascular smooth muscle cell Falck, J. R., see Wheelan, P., 1514 Fitzsimmons, M. E., Baggs, R. B. and migration and proliferation by a Fan, F., Compton, D. R., Ward, S., Melvin, Anders, M. W.: Nephrotoxicity 2-aminochromone U-86983, 4i5 L. and Martin, B. R.: Develop- and hepatotoxicity of 5,6-di- Erikson, L. J., see Law, P. Y., i686 ment of cross-tolerance between chlore-4-thia-5-hexenoic acid: Ev- Erythromycin derivatives, EM574 motilin 9-, CP idence for fatty acid beta-oxida- agonistic profile, in human gas- 55,940 and WIN 55,2i2, i383 tion-dependent bioactivation, 515 tric antrum, 574 Fan, P., Visentin, S. and Weight, F. F.: Flavoprotein inhibitors, diphenyleneiodo- Escandon, N. A., see McCall, R. B., 776 Effects of cocaine on the seroto- nium sulfate, inhibition of glyc- Esposito, E., see Prisco, S., 83 mn-induced inward current in rat eryl trinitrate by, 708 Estrogen, effects on cardiovascular re- nodose ganglion neurons, 262 Flockerzi, V., see Mehrke, G., 1483 sponses of premenopausal men- Fantofarone, see SR33557 Flow cytometry, articular chondrocyte, of keys, 67i Farhood, A., see Liu, P., 438 free radical production, effects of Estrus cycle, seizure susceptibility during, Farina, P. R, Graham, A. G., Hoffman, A. fluoroquinolones on, 1544 i64 F., Watrous, J. M., Borgeat, P., 4-[3-(4-Fluorobenzoyl)propyl]-N-cyclo- ET, see Endothelin Nadeau, M., Hansen, G., Dinallo, hexyl-i-piperazinecarboxamide Ethanol R. M., Adams, J., Miao, C. K, hydrochloride, see FG5803 acute, effects on splemc NK cells, in Lazer, E. S., Parks, T. P. and a-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidi- mouse, 722 Homon, C. A.: BIRM 270: A novel nyl)-1-piperazine butanol, regula- 13-adrenergic modulation of, in rat brain, inhibitor of arachidonate release tion of dopamine release from rat i175 that blocks leukotriene B4 and striatum by, 212 cellular adaptation in NGiO8-i5 cells to, platelet-activating factor biosyn- i-[2-[bis(4-Fluorophenyl)-methoxy]ethyl]- mediation by adenosine recep- thesis in human neutrophils, 4-(3-phenylpropyl)piperazine, see tors, 542 i4i8 GBR12909 effects on cardiac output, in spontane- Farrington, H., Mendelsohn, F., Chan, S., Fluoroquinolones, chondrotoxicity in vitro, ously hypertensive and normo- Reinlib, L. and Guggino, S.: 1544 tensive rats, iiSO Strychnine-binding proteins in Flurbiprofen, inhibition of hPGHS-i and effects on 5-HT3 receptors, 898 intestinal cells: Novel brucine -2 by, 927 effects on inward rectification in rat lo- binding site with binding affini- Folco, G., see Wheelan, P., 1514 cue ceruleus neurons, 334 ties for alkaloids, i074 Ford, C., see Filtz, T. M., 1574 1994 Index 1729

Forebrain, Foe-like immunoreactivity in- Gately, S., see Takano, S., 1027 Gold, L. H., see Schulteis, G., 1391 duction patterns in, for prediction GBR129O9, antagonism of cocaine effects Gonadotropin-releasing hormone, regula- of atypical antipsychotic activity, on dopamine by, in rat, 1216 tion of M-current in sympathetic 1058 Gee,KW.,seeFinn,D.A., 164 neurons by, 581 Formaldehyde nociceptive test, effects of Gekle, M., Mildenberger, S., Freudinger, Gonzalez-Alvear, G. M. and Werling, L. L.: ET-A and ET-B receptors on, 156 R. and Silbernagl, S.: The myce- Regulation of [3H]dopamine re- Foe, neuroleptic-induced expression of, toxin ochratoxin-A impairs pro- lease from rat striatal slices by 1058 tein uptake in cells derived from sigma receptor ligands, 212 Fox-Threlkeld, J.-A.E.T., see Hryhorenko, the proximal tubule of the kidney Gopalakrishnan, M., see Sullivan, J. P., L. M., 918 (opossum kidney cells), 1 624 FR139317, effects on thermal nociception, Gellai, M., see Brooks, D. P., 769 Gorbea-Oppliger, V. J., Melaragno, M. G., 156 Gelperin, D., Mann, D., Del Valle, J. and Potter, G. S., Petit, R. L. and France, C. P., see Gerak, L. R., 993 Wiley, J. W.: Bradykinin (Bk) in- Fink, G. D.: Time course of bear- Franson, R. C., see Tramposch, K M., 852 creases cytosolic calcium in cul- tan blockade ofangiotensin II hy- Free radical production, articular chon- tured rat myenteric neurons via pertension versus blockade of an- drocyte flow cytometry of, effects Bk-2 type receptors coupled to gietensin II fast presser effects, of fluoroquinolones on, 1544 mobilization of extracellular and 804 Freudinger, R., see Gekie, M., 1 intracellular sources of calcium: Gordon, A. S., see Sapru, M. K, 542 Freund, R. K., see IAn, A.M.-Y., 1175 Evidence that calcium influx is German, A. J., see Vargas, H. M., 748 Friedman, E., see Butkerait, P., 422 prostaglandin dependent, 507 Goso, C., see Maggi, C. A., 1489 Friedman, Z. Y.: The antitumor agent ta- Gender differences, in prenatal cocaine ef- Goudreau, J. L., Wagner, E. J., Looking- moxifen inhibits breakdown of fects on 5-HT1 receptors, in rat land, K J. and Moore, K E.: polyphosphoinositides in GH4C1 r-Aminobutyric acid receptor-me- cells, 238 progeny, 1453 Gerak, L. R., Butelman, E. R., Woods, J. diated regulation of periventricu- Frith, S., see O’Donnell, J. M., 246 H. and France, C. P.: Antinocicep- lar-hypophysial depaminergic Fructose-fed hyperinsulinemic hyperten- tive and respiratory effects of nal- sive rats, antihypertensive effects neurons: Possible role in mediat- buphine in rhesus monkeys, 993 ing stress- and 5-hy- of metformin in, 1334 Fujikura, K, see Satoh, M., 574 Geyer, M. A., see Bakshi, V. P., 787 droxytryptamine-induced de- GH4C1 cells, tamoxifen inhibition of creases in neuronal activity, 1000 Fujita, T., see Yodoya, E., 1509 polyphosphoinositides in, 238 GPA 1657, discriminative stimulus and in combination with 13-Funaltrexamine, Giachetti, A., see Maggi, C. A., 1489 kappa opioid agonists, antinoci- analgesic effects of, in vivo appar- Gianoulakis, C., see Guillaume, P., 1656 ent pA analysis with naltrexone ceptive effects, in squirrel men- Gibbons, N., see Mattana, J., 311 for, in rats, 959 keys, 1501 Giembycz, M. A., see Dent, G., 1167 GPLP, see Guinea pig lung parenchyma Funk, C. D., see Laneuville, 0., 927 Gills, A. M., Choi, M., Mathison, H. J. and Furosemide G-proteins Parsons, H. G.: Influence of di- autacoid production by, 1611 effects in dopamine receptor supersensi- etary fat on the pharmacodynam- tivity, 422 effects on distal convoluted tubule cells, ice of quiidine, procainamide levels in asthma, in antigen-challenged 403 and tocaiide in isolated perfused guinea pigs, 1713 Fusamoto, H., see Oshita, M., 20 Fusco, 0., see Patrignani, P., 1705 rabbit hearts, 176 mediation of amitraz inhibition of insu- Giuliani, S., see Maggi, C. A., 1489 lin release by, in rat beta cells, GABA, see y-Aminobutyric acidA Gleason, J., see Brooks, D. P., 769 1240 Galiano, A., see Lepretre, N., 1209 Gleason, J., see Nambi, P., 755 precoupling with alpha-2B adrenocep- Ganci, A., see Patrignani, P., 1705 Gleason, J. G., see Ohlstein, E. H., 762 tore, in PC12 cells, 1520 Ganglion neurons Glenn, T. C., see Li, Z., 1135 Grace, A. A., see Pucak, M. L., 1181 basal output, Dl agonist modulation of, Glibenclamide, effects en coronary vasoac- Graham, A. G., see Farina, P. R., 1418 in rats, 1434 tivity of adenosine receptor ago- Granneman, J. G., see Chaudhry, A., 1253 nodose, cocaine effects on 5-HT-induced nists, 14 Grant, D., see Asplund, A., 609 inward current in, 262 Gloff, C. A., see Doctrow, S. R., 229 Granulocyte colony-stimulating factor, re- Gao, X., Buffington, C.A.T. and Au, J.L.- N-Glucuromdation, SR 47436, by rat, combinant human, pharmacoki- S.: Effect ofinterstitial cystitis en monkey and human hepatic mi- netics, in rats, monkeys and hu- drug absorption from urinary crosomal fractions, 91 mans, 1535 bladder, 818 Glutamate Granubomatous colitis, chronic, nitric ox- Gap-junctional intercellular communica- ethanol inhibition of, in nucleus accum- ide effects on, 1114 tion, beta-adrenergic regulation bens, 1566 Grazzii, E., see Deminice, C., 107 of, in rabbit gastric epithelial neonatal hypoxia-associated increase in, Greco, A., see Patrignam, P., 1705 cells, 397 1299 Greenberg, A. H., see Zalcman, S., 977 Garbarg, M., see Ligneau, X., 452 Glyceryl trinitrate, inhibition by diphe- Green-Johnson, J. M., see Zalcman, S., 977 Gastric antrum, EM574 metilin agonistic nyleneiodonium sulfate, 708 Griffiths, R. R., see Evans, S. M., 683 proffle in, in human, 574 P-Glycoprotein, cempartmentalizatien of Grisham, M. B., Specian, R. D. and Zim- Gastric emptying, of solid meals, regula- doxorubicin in cells expressing, merman, T. E.: Effects of nitric tion by nitric oxide synthase, 660 1286 oxide synthase inhibition on the Gastric epithelial cells, gap-junctional in- Glycyl-l-glutamine, inhibition of f3-ender- pathophysiobogy observed in a tercellular communication in, be- pin-induced cardiorespiratory de- model of chronic granubomatous ta-adrenergic regulation of, in pression by, 952 colitis, 1114 rabbit, 397 Gly-l-Gin, see Glycyl-l-glutamine Grotewiel, M. S., Chu, H. and Sanders- Gastric ulcers GM1, see Monosialoganglioside Bush, E.: m-Chborophenylpipera- indomethacin-induced, sympathetic Godeneche, D., see Cussac, C., 1353 zine and m-trifluoromethylphe- nerve effects in, in rats, 695 Goetz, A. S., Lutz, M. W., Rimele, T. J. and nybpiperazine are partial agonists psychological stress, 5-HT3 receptor ef- Saussy, D. L., Jr.: Characteriza- at cloned 5-HT2A receptors ex- fects in, in mouse, 100 tion of alpha-adrenoceptor sub- pressed in fibreblasts, 1122 Gastrointestinal contractions, phase III, types in human and canine pros- Growth retardation, intrauterine, AT1 metiin-induced, inhibition by tate membranes, 1228 binding sites in placentae from pentagastrin, in Heidenhain Ggelein, H., see Ken, K, 632 pregnancies with, 1007 pouch dogs, 1471 Gohda, M., see Matzno, S., 1666 Guan, W., see Filtz, T. M., 1574 1730 Index Vol. 271

Guanidines, substituted, in vitro neure- dence for the involvement of 5-hy- He, A. C., see Dordal, M. S., 1286 protection by, 1080 droxytryptamine 4 receptors in Heifer, B. J., see IAn, A.M.-Y., 1175 Guanine nucleotide-binding proteins, see 5-hydroxytryptophan-induced di- Hoffman, A. F., see Farina, P. R., 1418 G-proteins arrhea in mice, 741 Hofmann, F., see Mehrke, G., 1483 Guggino, S., see Farrington, H., 1074 Heidenhain pouches, pentagastrin inhibi- Holt, I. L., see Torres, G. E., 255 Guillaume, P., Gutkowska, J. and Gianou- tion of metilin-induced phase III Homen, C. A., see Farina, P. R., 1418 lakis, C.: Increased plasma atrial contractions in dogs with, 1471 Hong, K W., Rhim, B. Y., Shin, Y. W. and after acute in- HEK-293 cells, up-regulation of D21 dopa- Yoo, S.-E.: Characterization of PD jection of alcohol in rats, 1656 mine receptors in, mechanisms 121981- and CGP 42112-induced Guilbon, G., see Deminice, C., 107 of, 1574 unmasking of low concentration Guinea pig lung parenchyma, Schultz- Heller-Harrison, R., see Doctrow, S. R., effects of angiotensin II in rabbit Dale response in, 615 229 abdominal aorta, 1591 Gully, D., see Labbd-JuIll#{233}, C., 267 Heme oxygenase-1, regulation of heart Hoover, J. L., see Erickson, L. A., 415 Guo, H., see Robinson, S. E., 1234 cGMP by, 408 Hori, M., see Amane, K-I., 1359 Gustafsson, B., see Bj#{246}rk,A., 1338 Hepatic artery, TNP-470 in MCT solution Horie, T., see Shimamura, H., 370 Gutkowska, J., see Guillaume, P., 1656 via, antitumor effects, in rats Hormones, see also specific hormones Guzman, N. J., Chandler, L. J., 67 see with Walker 256 carcinosarcoma neuroendocrine, mediation by 5-HT GYKI 52466, non-NMDA receptor antage- in liver, 1267 receptors msm by, 25 Hepatic reperfusion injury, reduction by differential receptor reserve for, 1246 Hadjiconstantinou, M., see Krajnc, D., U-74006F, 438 effects of prenatal cocaine exposure 1299 Hepatic vasculature, vasedilative effect of on, in male vs female rat progeny, Hadlock, T., see Desai, S., 220 ebselen on, 20 1453 Haga, N., see Yamamoto, 0., 1471 Hepatocytes, ethanol-treated, LTB4 me- Hoshino, J., see Igarashi, R., 1672 Halineme, G., see Wilkinson, A., 1314 tabolism in, in rats, 1514 House, J. D., see Walker, E. A., 959 Haloperidol Hepatotoxicity HPGHS, see Human prostaglandin H syn- behavioral effects, 638 carbon tetrachloride, methamphet- thase effects of GM1 en, in rats, 1193 amine potentiatien of, in mice, Hropot, M., see Wiemer, G., 1611 catalepsy induced by, dopamine cell 1051 Hryhorenko, L. M., Woskowska, Z. and density and, 969 DCTH, 515 Fox-Threlkeld, J.-A.E.T.: Nitric chronic, effects on neuretensin and c-fos Hermsen, B., see Alkonden, M., 494 oxide (NO) inhibits release of ace- mRNA in rat neostriatal subre- Herzig, S., see Neumann, J., 535 tybcheline from nerves of isolated gions, 460 Hexachborecycbohexanes, effects on circular muscle of the canine il- Halothane, effects on 5-HT3 receptors, 898 GABA-dependent chloride flux, in eum: Relationship to motility and Halter, F., see Scheurer, U., 7 cortical neurons, 1616 release of nitric oxide, 918 Hamel, L. T., see Silver, P. J., 1143 (R)2-[(R)-2-S)-2-[[1-(Hexahydre-1H-az- HSP32, see Heme oxygenase-1 Hammond, J. R.: Functional reconstitu- epinyl)lcarbonyllamino-4-methyl- HSP7O, see Heat shock protein p72 tion of pharmacologically distinct pentanoyl]amine-3-[3-(i-methyl- Hsu, S.A.O., see Bonhaus, D. W., 484 subtypes of nucleoside transport- 1H-indolyl)}propionyl]amine-3- Hsu, W. H., see Chen, T.-H., 1240 ers in liposomal membranes, 906 (2-pyridyl)propionic acid, see 5-HT, see Serotonin Hanane, M., see Shimamura, H., 370 FR139317 HTLV-I, see Human T-cell leukemia virus Hansen, G., see Farina, P. R., 1418 Hexum, T. D., Zheng, J. and Thu, J.: Neu- type! Harbison, R. D., see Roberts, S. M., 1051 ropeptide Y inhibition of nicotinic 5-HTP, see 5-Hydrexytryptophan Harris, D. W., see McCall, R. B., 875 receptor-mediated chremaffin cell Huang, K-X. and Walters, J. R.: Electro- Harris, L. T., see McCall, R. B., 776 secretion, 61 physiological effects of SKF Harris, R. A., see Machu, T. K, 898 Hill, J. L., see Aulakh, C. S., 143 38393 in rats with reserpine Hartwell, P., see Thummel, K E., 549 Hippocampus treatment and 6-hydroxydopam- Hasegawa, S., see Lee, J. Y., 1713 5-HT4 receptor antagonists in, in adult, ine-induced nigrostriatab lesions Havens, M. B., see Trampesch, K M., 852 255 reveal two types of plasticity in Hayem, G., see Thuong-Guyot, M., 1544 LW-blocking effect efethanol in, effects Dl dopamine receptor modula- Hearn, W. L., see Staley, J. K, 1678 of crocin en, 703 tion ofbasal ganglia output, 1434 Heart, see also under Cardiac nicotinic receptor subunits and diversity HuDREG-200 (mAb), cardiopretective ef- allegrafts, effects of liposomal methyl- in, in rat, 494 fects in feline myocardial reperfu- prednisobene on survival, in rats, H.iraoka, M., see Sawanobori, T., 302 sion injury, 134 868 Hirata, A., see Lee, J. Y., 1713 Human alpha-2A adrenoceptors, porcine beta-2 adrenoceptor effects in, in guinea Hirata, F., see Lee, J. Y., 1713 orthobeg pharmacological charac- pig, 386 Histamine, interactions with leukotriene teristics, 735 CGMP in, regulation by heme oxygen- in GPLP anaphylaxis, 615 Human blood prostaglandin endoperoxide ase-i, 408 Histamine receptors eynthases, characterization of, dietary fat effects en pharmacodynam- colenic mucosal subtypes, in canine, 1705 ics of quinidine, precainamide 1016 Human chronic myebogenous leukemia and tocaiide in, in rabbit, 176 H3 cells (K562 cells), cloning TXA effects of A1 adenoeine agonist on, in cerebral, [1m1]iodoproxyfan antage- receptors from, 1034 guinea pig, 1371 met binding to, 452 Human CYP3A probe, midazolam as, 549, effects of calyculin A on, 535 in myocardial isehemia, 1259 557 heme oxygenase-1 in, induction by hy- regulation of exocytotic norepineph- Human dopamine transporter, regulation perthermia, 408 tine release by, 1259 of, 1678 sodium channels in, cocaethylene block- Hitzemann, B., Dams, K, Kanes, S. and Human eosinophil respiratory burst, PDE ade of, 319 Hitzemann, R.: Further studies N inhibitor effects on, 1167 TA 2005 selectivity in, in guinea pig, 386 on the relationship between dopa- Human ETA and ETB receptors, SB Heart failure, congestive, effects of febodip- mine cell density and haloperidol- 209670 effects on ET-i binding to, me in, 1409 induced catalepsy, 969 755 Heat shock protein p72, cycbepentenene Hitzemann, R., see Hitzemann, B., 969 Human gastric antrum, EM574 motiin prostaglandin regulation of, 1096 Hia, T., see Laneuville, 0., 927 agonistic profile in, 574 Hegde, S. S., Moy, T. M., Perry, M. R., Hlasta, D., see Silver, P. J., 1143 Human granubecyte colony-stimulating Loeb, M. and Eglen, R. M.: Evi- HO-i, see Heme oxygenase-1 factor, recombinant, pharmacoki- 1994 Index 1731

netics, in rats, monkeys and hu- Hyperthermia, induction of heart HO-i In vivo apparent pA2 analysis, with nab- mans, 1535 by, 408 trexone, for discriminative stimu- Human hepatic micresomes, N-glucu- Hypogastric nerve, effects in internal anal bus and analgesic effects of opiate ronidation of SR47436 by, 91 sphincter, in opossum, 277 agonists, in rats, 959 Human monocytic THP-1 cells, effects of Hypothalamus Indomethacin prostacycin analogs on, 446 GABA receptor mediation of dopaminer- antral and corpus lesions induced by, Human placentae, AT1 binding sites in, gic neurons in, 1000 sympathetic nerve effects in, in lateral, nicotine reinforcement with 1007 rats, 695 brain stimulation at, 294 Human prostaglandin H synthase, inhibition of hPGHS-1 and -2 by, 927 Hypoxia isozymes hPGHS-i and -2, inhibi- Infection, early HTLV-I, effects of cycle- in vitro, effects en vasorelaxation in rat tion by NSAIDs, 927 pentenone prostaglandins on my- pulmonary arteries, 845 Human T-cell leukemia virus type I, early ebeid cells during, 1086, 1096 infection with, effects of cycbopen- neonatal, GM1 ganglioside effects on, 1299 Inflammation tenone prostaglandins on myeboid antinociceptive effects ofU-50,488H and cells during, 1086, 1096 pulmonary vasoconstriction with, levcromakalim effects on, in rat, dexmedetomidine against, 1306 Humans 326 cobenic, with chronic granubomatous co- behavioral effects and abuse liability of litis, nitric oxide effects on, 1114 tandospirene and alprazolam in, lacobelli, S., see Patrignam, P., 1705 effects of tepoxalin against, 1399 683 Iberiotoxin, effects on NANC and NO do- release of excitatory amino acids in- drug discrimination assessment of opi- nor relaxations in guinea pig tra- duced by, prevention by GABAA eids in, three-choice saline-hydro- chea, 782 receptor antagonists, in rats, 76 morphene-butorphanol proce- Ibuprofen, inhibition of hPGHS-i and -2 topical effects of PLA inhibitor against, dure, 48 by, 927 oriental, metabolic disposition of imi- !d#{226}np#{225}#{225}n-HeikkilA,J. J., Kalso, E. A. and 852 pramine in, 860 Sepp#{226}l#{225},T.: Antineciceptive ac- Inhibitory reflex, rectoanal, hypegastric Humphrey, S. J., see Erickson, L. A., 415 tions ofdexmedetomidine and the nerve effects in, in opossum, 277 Hydralazine, interaction with hydrazine kappa-opioid agonist U-50,488H Injury, see Ischemia-reperfusion injury derivatives, 171 against noxious thermal, me- Insulin Hydrazine derivatives, hydralazine inter- chanical and inflammatory stim- effects in indomethacin-induced antral action, 171 ufl, 1306 and corpus lesions, in rats, 695 Hydrolysis Ifetroban, inhibition of cremophor vascu- inhibition by amitraz, in rat beta cells, cAMP, PDE N inhibitor effects on, 1167 bar effects by, 730 1240 phesphoinesitide, in contractile effects Igarashi, R., Hoshino, J., Ochiai, A., topical ocular, absorption-enhancing ef- of guinea pig tracheal 5-HT re- Morizawa, Y. and Mizushima, Y.: fects of alkybglycesides on, in rat, ceptors, 832 Lecithiized superoxide die- 1274 Hydromorphone, drug discrimination as- mutase enhances its pharmaco- Intercellular communication, gap-junc- sessment of opioids in humans, logic potency by increasing its cell tional, beta-adrenergic regulation 48 membrane affinity, 1672 of, in rabbit gastric epithelial 1-(2’-Hydroxy-5’-chlorophenyl)-5-triflu- fleum cells, 397 oromethyl-2(3H) benzimida- circular muscle nerves in, NO inhibition Interleukin-i, effects in amygdala neu- zolone, see NS-004 of acetylcholine release from, in rons, 590 (1)-B-2’-Hydroxy-2,9-dimethyl-5-phenyl- canine, 918 Interleukin-1, effects of prostacycin ana- 6,7-, see GPA 1657 contractions of logs en, in human menocytic 6-Hydroxydopamine lesions M2-induced, inhibition by pertussis THP-1 cells, 446 D1 antisense inhibition of D1 behaviors toxin, in guinea pig, 1042 Interleukin-2, effects en antigen-specific with, in mice, 1462 naboxone-induced, after preincubation 1gM PFC responses, sympathetic SKF 38393 effects on basal ganglia out- with morphine, NMDA receptors mediation of, 977 put with, in rats, 1434 in, in guinea pig, 1365 Internal anal sphincter, hypogastric nerve 3-Hydroxy-leukotriene B4, stereochemical neurotensin receptors in, in guinea pig, effects in, in opossum, 277 analysis and biological activity, in 267 Interstitial cystitis, effects on drug absorp- ethanol-treated rat hepatocytes, 6-keto-PGF1a release from, NK1 recep- tion from urinary bladder, 818 1514 tor mediation of, in canine, 39 Intestinal cells, strychnine-binding pro- 6-[6-(4-Hydroxypiperidinyl)-hexexy]-3- Imamura, M., Poli, E., Omeniyi, A. T. and teins in, 1074 methyfflavone hydrochloride, reg- Levi, R.: Unmasking of activated Intestinal membrane, permeability of tet- ulatien of depamine release from histamine H3 receptors in mye- ragastrin across, in rats, 1509 rat striatum by, 212 cardial ischemia: Their role as Intracellular calcium 3a-Hydroxy-5a-pregnan-20-one, anticon- regulators of exocytotic nerepi- bradykiin effects on, in rat myenteric vulsant effects of, sensitivity to, nephrine release, 1259 neurons, 507 during estrus cycle, 164 3-(1H-Imidazol-4-yl)propyl-(4-iodephe- in contractile effects of tracheal 5-HT 5-Hydroxytryptamine, see Serotonin nyl)-methyl ether, see ledoproxy- receptors, in guinea pig, 832 5-Hydroxytryptophan-induced diarrhea, fan 5-HT effects in, in mice, 741 Imipramine effects of picomolar PAP on, 824 Hyperinsulinemic hypertension, antthy- beta adrenoceptor down-regulation by, mediation by endothelial ETA receptors, pertensive effects of metfermin time course of, in rat brain, 1699 in rabbit aortic valve, 1359 in, in fructose-fed rats, 1334 metabolic disposition in oriental sub- mediation by prostaglandins, 507 Hyperpolarization, membrane, IL-ip in- jects, 860 NMDA receptor-induced increases in, duction of, in amygdala neurons, Immunogbobin M, antigen-specific PFC re- steroid modulation of, 677 590 sponses to, sympathetic media- RMP-7 effects en, in rat brain microvas- Hypertension tion of IL-2 effects on, 977 cular endothelial cells, 229 angietensin II, bosartan blockade of, 804 Immunohistochemistry, Foe, determina- Intracellular compartmentalization, of hyperinsulinemic, antthypertensive ef- tion of EPS liability of antipsy- doxorubicin in cells expressing P- fects of metformin in, in fructose- chotics with, 1058 glycoprotein, 1286 fed rats, 1334 Immunosuppression, effects of liposomal Intrathecal mcotinic agents, stimulatory spontaneous, effects of ethanol on car- methylprednisebone on, in rats, pathways and sites of action of, diac output in, in rats, 1150 868 1550 1732 Index Vol. 271

Intrauterine growth retardation, AT1 Johnson, D. M., see Parrish, M. B., 39 Kobayashi, S., see Kuwabara, T., 1535 binding sites in placentae from Jonsson, W. and Dahl#{233}n,S.-E.: Interac- Kodama, H., see Kuratani, K, 695 pregnancies with, 1007 tions between leuketrienes and Ken, K, Krause, E. and Gogelein, H.: In- Inward rectification histamine in the anaphylactic hibition of K4 channels by chbor- in locus ceruleus neurons, ethanol ef- contraction ofguinea pig lung pa- premazine in rat ventricular mye- fects on, in rat, 334 renchyma, 615 cytes, 632 of nAChR whole-cell currents in hip- Jouin, P., see Dominice, C., 107 Koob, G. F., see Schulteis, G., 1391 pocampal neurons, in rat, 494 Jusko, W. J., see Mishina, E. V., 868 Keep, D. R., see Daikh, B. E., 1427 Iedoproxyfan, binding to cerebral hista- Koreans, metabolic disposition of imipra- K562 cells, cloning TXA receptors from, mine H3 receptors, 452 mine in, 860 1034 Irwin, R. P., Lin, S.-Z., Rogawski, M. A., Kerolkiewicz, R., see Tepperman, B. L., Kainate channel blockers, anticonvulsant Purdy, R. H. and Paul, S. M.: Ste- 1477 activity, 25 reid potentiation and inhibition of Koyama, E., Sohn, D.-R., Shin, S.-G., Kalso, E. A., see Id#{226}np#{225}#{226}n-Heikkil#{226},J. J., N-methyl-D-aspartate receptor- Chiba, K, Shin, J.-G., Kim, Y.-H., 1306 mediated intracellular Ca re- Echizen, H. and Ishizaki, T.: Met- Kamada, T., see Oshita, M., 20 sponses: Structure-activity stud- abobic disposition of imipramine Kameda, Y., see Ueda, F., 397 ies, 677 in oriental subjects: Relation to Kamendulis, L. M. and Corcoran, G. B.: Ischemia-reperfusion injury metoprobob a-hydroxybatien and DNA as a critical target in toxic antiplatelet effects of cGMP in, in rats, S-mephenytoin 4’-hydroxylation cell death: Enhancement of dim- 1203 phenotypes, 860 ethylmtrosamine cytotoxicity by arrhythmias, sotalol effects on, 184 Koyama, H., see Satoh, M., 574 DNA repair inhibitors, 1695 hepatic, reduction by U-74006F, 438 Kozarich, J. W., see Doctrow, S. R., 229 Kanes, S., see Hitzemann, B., 969 myocardial Krajnc, D., Wemlinger, T. A., Neff, N. H. Kang, C-H., see Sullivan, J. P., 624 cardioprotective effects of mAb Hu- and Hadjiconstantinou, M.: Neo- Kaolin and carrageenan model, of arthri- DREG-200 in, in feline, 134 natal hypoxia: Early neurotrans- tis, prevention by spinal GABAA H3 receptors in, 1259 mitter responses and the conse- receptor antagemsts, in rats, 76 Ishida, N., see Matzno, S., 1666 quences of treatment with GM1 Karaki, H., see Amano, K.-I., 1359 Ishizaki, T., see Koyama, E., 860 ganglieside, 1299 Karlsson, J.O.G., see Asplund, A., 609 Isoflurane Krause, E., see Ken, K, 632 Karpinski, E., see Liu, Q.-Y., 935, 944 effects on 5-HT3 receptors, 898 Krause, J. E., see Simmons, M. A., 581 Kato, Y., see Kuwabara, T., 1535 inhibitory effects on Ca channels, in Kreeger, J. S., Kitto, K F. and Larson, A. Kawai, Y., see Miyahara, H., 379 guinea pig portal vein smooth A.: Substance P N-terminal me- Kawano, S., see Oshita, M., 20 muscle cells, 1159 tabobites and nitric oxide mediate Khan, I. M., Taylor, P. and Yaksh, T. L.: Isoproterenol capsaicin-induced antinocicep- Stimulatory pathways and sites antidepressant-like effects of, beta-i tion in the adult mouse, 1281 ofaction ofintrathecally admims- and beta-2 adrenergic receptors Krisch, I., Bobe-Vunduk, B., Pepelnak, M., tered nicotinic agents, 1550 in, 246 Lavric, B., Ocvirk, A., Budihna, Kidneys, see also under Renal effects on gap-junctional intercellular M. V. and Sket, D.: Pharmacobeg- brush-border membranes, cefadroxiu/ communication, in rabbit gastric ical studies with two new ergoline W-symport systems in, in rat, epithelial cells, 397 derivatives, the potential antipsy- 1327 Itoh, Y., Ogasawara, T., Mushiroi, T., chetics LEK-8829 and LEK-8841, distal convoluted tubule cells, loop di- Yamazaki, A., Ukai, Y. and 343 uretic effects on, 403 Kimura, K.: Effect ofNS-3, a thy- Kuge, Y., see Yanai, S., 1267 ischemia-reperfusion injury of, anti- rotropin-releasing hormone ana- Kunze, K L., see Thummel, K E., 549, 557 platelet effects of cGMP in, in log, on in vivo acetylcholine re- Kupiec-Weglinski, J. W., see Mishina, E. rats, 1203 lease in rat brain: Regional V., 868 proximal tubule-derived opossum kid- differences and its sites of action, Kuratani, K, Kodama, H. and Yamaguchi, ney cells, endocytosis in, 1 884 I.: The differential roles of sympa- Kim, D.J.B., see Briom, J. D., 353 Itoh, Z., see Satoh, M., 574; Yamamoto, 0., thetic nerve activity in the pathe- Kim, Y. D., see Williams, J. K, 671 1471 genesis of antral and corpus le- Kim, Y.-H., see Koyama, E., 860 Iversen, L. J., see O’Rourke, M. F., 735 siens induced by indomethacin in Kimura, K, see Itoh, Y., 884 Iwameto, E. T. and Marion, L.: Pharmace- rats, 695 , endothelial, release of, enhance- logic evidence that spinal musca- Kuwabara, T., Kato, Y., Kebayashi, S., Su- ment by furesemide, 1611 rinic analgesia is mediated by an zuki, H. and Sugiyama, Y.: Non- Kirchner, T., see Argentieri, D. C., 1399 l-argiine/mtric oxide/cyclic GMP linear pharmacokinetics of a re- Kirk, C. J., Reddy, N. L., Fischer, J. B., cascade in rats, 601 combinant human granulocyte Wolcott, T. C., Knapp, A. G. and colony-stimulating factor deriva- Jackson, G. F., see Robinson, S. E., 1234 McBurney, R. N.: In vitro neuro- tive (nartograstim): Species dif- Jackson-Stone, M., see Dordal, M. S., 1286 protection by substituted guani- ferences among rats, monkeys Jaeschke, H., see Liu, P., 438 dines with varying affinities for and humans, 1535 Jakeman, L. B., see Bonhaus, D. W., 484 the N-methyl-D-aspartate recep- James, M. K, see Lutz, M. W., 795 tor ionophere and for sigma sites, L-663,581, bleed-brain barrier permeabil- James, R. C., see Roberts, S. M., 1051 1080 ity and in vivo activity, in rats, James-Kracke, M. R., Sexe, R. B. and Kitabgi, P., see Labbd-Julli#{233}, C., 267 1197 Shukla, S. D.: Picemolar platelet- Kitto, K F., see Kreeger, J. S., 1281 Labb#{233}-Julli#{233},C., Deschaintres, S., Gully, activating factor mobilizes Ca to Klingbeil, K., see Buerke, M., 134 D., Le Fur, G. and Kitabgi, P.: change platelet shape without ac- Knapp, A. G., see Kirk, C. J., 1080 Effect of the nenpeptide neuro- tivating phospholipase C or pro- Knapp, D. J., see Duncan, G. E., 1699 tensin antagonist, SR 48692, and tam kinase C: Simultaneous flu- Knock, G. A., Sullivan, M.H.F., McCarthy, two enantiomeric analogs, SR orometric measurement of A., Elder, M. G., Pelak, J. M. and 48527 and SR 49711, on neure- intracellular free Ca cencentra- Wharton, J.: Angiotensin II (AT1) tensin binding and contractile re- tion and aggregation, 824 vascular binding sites in human sponses in guinea pig ileum and Japanese, metabolic disposition of imipra- placentae from normal-term, pre- colon, 267 mine in, 860 eclamptic and growth retarded Lacal, P. M., Amici, C., Bonmassar, E. and Jiang, J. B., see Takano, S., 1027 pregnancies, 1007 D’Onofrio, C.: Effects of cycbopen- Johnson, B. G., see Watts, S. W., 832 Knuepfer, M. M., see Branch, C. A., 1103 tenone prostaglandins on myeboid 1994 Index 1733

cells during early infection with SKF 38393 effects on basal ganglia Liquiritigemn conjugates, multiple biliary HTLV-I. II. Regulation of synthe- output with, in rats, 1434 excretion systems, in rats, 370 sis of inducible p’72 heat shock Leslie, S. W., see Lee, Y.-H., 1291 Little, K Y., see Duncan, G. E., 1699 protein, 1096 Leukemia Little, W. C., see Cheng, C.-P., 1409 Lacal, P. M., Pugbiamello, A., Benmassar, early HTLV-I, effects of cycbopentenone Liu, M.-R., see Emmerson, P. J., 1630 E. and D’Onefrio, C.: Effects of prostaglandins on myeboid cells Liu, P., Vonderfecht, S. L., Mcguire, G. M., cycbopentenone prostaglandins on during, 1086, 1096 Fisher, M. A., Farhood, A. and myeboid cells during early infec- human chronic myebogenous K562 cells, Jaeschke, H.: The 21-aminos- tion with HTLV-I. I. Cell differen- cloning “XA2 receptors from, teroid tirilazad mesylate protects tiatien determines sensitivity to 1034 against endotoxin shock and prostagbandins and virus infec- myelemenocytic cell lines, comparison of acute liver failure in rats, 438 tion, 1086 retinoid and VD3 analog effects Liu, Q.-Y., Karpinski, E. and Pang, P.KT.: Lago, A., see Ohbstein, E. H., 762 on, 193 1-Channel modulation by alpha-i Lago, M. A., see Nambi, P., 755 Leukotriene B4 adrenoceptor activation in neona- Lahey, A. P., see Lutz, M. W., 795 inhibition by BIRM 270, in human neu- tab rat ventricular cells: Intracel- Laneuville, 0., Breuer, D. K, Dewitt, D. trophils, 1418 lular mechanisms, 944 L., Hia, T., Funk, C. D. and metabolites from ethanol-treated rat Liu, Q.-Y., Karpinski, E. and Pang, P.KT.: Smith, W. L.: Differential inhibi- hepatocytes, 1514 The I-type calcium channel cur- tion of human prostaglandin en- Leukotrienes rent is increased by alpha-i adre- doperexide H synthases-i and -2 effects of PLA2 inhibitors on, 852 noceptor activation in neonatal by nensteroidal anti-inflamma- interactions with histamine in GPLP rat ventricular cells, 935 tory drugs, 927 anaphylaxis, 615 Liu, Y.-W., Asaoka, Y., Suzuki, H., Yoshi- Lappi, S. E., see Wagner, J. P., 472 Leung, E., see Bonhaus, D. W., 484 moto, T., Yamameto, S. and Larson, A. A., see Kreeger, J. S., 1281 Levcromakalim, effects on hypoxic pulmo- Chang, W.-C.: Induction of 12-li- Larsen, A. A., see Yukhananev, R. Yu., 1365 nary vasoconstriction and pulmo- poxygenase expression by epider- Lasker, J. M., see Daikh, B. E., 1427 nary artery contractions, in rat, mal growth factor is mediated by Lateral hypothalamic brain stimulation 326 protein kinase C in A43i cells, reinforcement, by nicotine, 294 Levi, R., see Imamura, M., 1259 567 Lavric, B., see Krisch, I., 343 Levy, A. D., see Rittenhouse, P. A., 1647 Liver, see also under Hepatic Law, P. Y., McGinn, T. M., Wick, M. J., Lewis, J. W., see Burke, T. F., 715 CYP2C11 over-expression by MSG in, in Erikson, L. J., Evans, C. and Loh, Li, Q., see Rittenhouse, P. A., 1647 adult male rats, 1067 H. H.: Analysis ofdelta-opioid re- Li, Z., Barrios, V., Buchholz, J. N., Glenn, CYP3A expression in ceptor activities stably expressed T. C. and Duckles, S. P.: Chronic midazolam characterization of, in hu- in CHO cell lines: Function of re- nicotine administration does net man, 557 ceptor density?, 1686 affect peripheral vascular reactiv- midazolam probe determination of, in Lazdunski, M., see Romey, G., 1348 ity in the rat, 1135 human, 549 Laser, E. S., see Farina, P. R., 1418 Ligneau, X., Garbarg, M., Vizuete, M. L., microsomes, N-glucuronidation of Le Fur, G., see Labbd-Jullie, C., 267 Diaz, J., Purand, K, Stark, H., SR47436 by, in rat, monkey and Lecithinized superoxide dismutase, phar- Schunack, W. and Schwartz, J.- human, 91 macobogic potency, 1672 C.: [1m1]Iodoproxyfan, a new an- portal pressure in, alcohol-induced ef- Lee, E. W., see Xu, X., 362 tagomst to label and visualize ce- fects en, prevention of, 20 Lee, J. Y., Uchida, Y., Sakamoto, T., rebral histamine H3 receptors, Walker 256 carcinosarcoma in, antitu- Hirata, A., Hasegawa, S. and 452 mor effects of MCT solution of Hirata, F.: Alteration ofG protein Lin, A.M.-Y., Freund, R. K, Heifer, B. J. TNP-470 via hepatic artery on, in levels in antigen-challenged and Palmer, M. R.: Ethanol-in- rats with, 1267 guinea pigs, 1713 duced depressions of cerebellar Liver failure, acute, protective effects of Lee, K S., see Xu, X., 362 Purkinje neurons are potentiated U-74006F against, in rats, 438 Lee, Y.-H., Spuhber-Phiffips, K, Randall, by f3-adrenergic mechanisms in Liver transplantation, CYP3A expression P. K and Leslie, S. W.: Effects of rat brain, 1175 after prenatal ethanol exposure on N- Lin, J. H., Chen, I.-W. and Lin, T.-H.: midazolam characterization of, in hu- methyl-D-aspartate-mediated cab- Blood-brain barrier permeability man, 557 cium entry into dissociated neu- and in vivo activity ofpartial ago- midazolam probe determination of, in rons, 1291 mets of benzodiazepine receptor: human, 549 Lefer, A. M., see Buerke, M., 134 A study of L-663,581 and its me- Lobron, C., see Alkondon, M., 494 Left ventricular function, effects of febedip- tabolites in rats, 1197 Local anesthetics, ionization and adsorp- me on, in ClIP, 1409 Lin, S.-Z., see Irwin, R. P., 677 tion in detergent micelles, drug LEK-8829, pharmacological studies, 343 Lin, T.-H., see IAn, J. H., 1197 fluorescence study of, 220 LEK-8841, pharmacological studies, 343 Linopirdine, release-enhancing effects, Locus ceruleus neurons, ethanol effects en Lemaire, G. A., see Stewart, R. B., 200 role of K , C1 and Na channels inward rectification in, in rat, 334 Lepretre, N., Arnaudeau, S., Mironneau, J., in, in rat cerebral cortical slices, Lodge, N. J.: Direct vaseconstrictor effects Rakotoarisea, L., Mironneau, C. 891 of sandimmune (cycbesporine A) and Galiano, A.: Ebectrophysiobegi- Linz, W., see Wiemer, G., 1611 are mediated by its vehicle creme- cal and radieligand binding studies Lipid metabolism, effects ofALO67i on, in phor EL: Inhibition by the throm- of elgodipine and derivatives in obese Zucker rats, 1666 boxane A/prostaglandin en- portal vein myocytes, 1209 Liposome-reconstituted nucleoside trans- doperoxide Lesher, G. Y., see Silver, P. J., 1143 porters, functional and pharma- ifetroban, 730 Lesions cobogical characteristics of, 906 Leeb, M., see Hegde, S. S.,741 gastric Liposomes Logue, A. R., see Maciag, C. M., 891 indemethacin-induced, sympathetic methylprednisobone in, effects on heart Lob, H. H., see Law, P. Y., 1686 nerve effects in, in rats, 695 allograft survival, in rats, 868 Lomasney, J. W., see O’Rourke, M. F., 735 psychological stress, 5-HT3 receptor nucleotide transport in, 906 Long-term potentiation, hippocampal, eth- effects in, in mouse, 100 5-Lipoxygenase inhibitors, tepoxabin, 1399 aneb inhibition of, effects of crecin 6-OHDA 12-Lipoxygenase, EGF-induced expression on, 703 D1 antisense inhibition of D1 behav- of, mediation by PKC, in A431 Leekingland, K J., see Goudreau, J. L., iors with, in mice, 1462 cells, 567 i000 1734 Index Vol. 271

Loop diuretics, effects on distal convoluted Manzini, S., see Maggi, C. A., 1489 MDL-72222, effects on DOM neuroendo- tubule cells, 403 Manzoni, 0., see Dominice, C., 107 crime effects, in rats, 143 Losartan, blockade of ATII hypertension Main, J., see Casado, M. A., 1638 MDMA, see 3,4-Methybenedioxymetham- by, vs blockade of ATII fast pres- Marion, L., see Iwamoto, E. T., 601 phetamine sor effects by, 804 Markou, A., see Schulteis, G., 1391 Mecamylamine, chronic, effects on nice- Loury, D. N., see Bonhaus, D. W., 484 Marks, M. J., see Collins, A. C., 125 tine sensitivity, 125 LW, see Long-term potentiation Marsh, C. L., see Thummel, K E., 549, 557 Mecbofenamate, inhibition of hPGHS-1 Lu, J., see Belardinelli, L., 1371 Martens, J., see Belardinelli, L., 1371 and -2 by, 927 Lungs, anaphylactic contraction of paren- Marti, E., see Perrier, L., 91 Medetomidine, inhibition of insulin re- chyma, interactions between leu- Marti, J., see Defacque, H., 193 lease by, in rat beta cells, 1240 kotrienes and histamine in, in Martin, B. R., see Fan, F., 1383 Medium-chain triglycerides, TNP-470 so- guinea pig, 615 Mash, D. C., see Staley, J. K, 1678 lutien, via hepatic artery, antitu- Lue, Y., see Coffins, A. C., 125 Masse, D., see Perrier, L., 91 mor effects, in rats with Walker Lutz, M. W., Morgan, P. H., James, M. K., Maternal cocaine abuse, maternal and fe- 256 carcinosarcoma in liver, 1267 Feldman, P. L., Brackeen, M. F., tal levels after, in rat, 1234 Medzihradsky, F., see Burke, T. F., 715; P., Schuster, S. V., Lahey, A. Mathematical model, of opioid analgesia, Emmerson, P. J., 1630 Bilotta, J. M. and Pressley, J. C.: 795 Meeker, S. N., see Undem, B. J., 811 A pharmacodynamic model to in- Mathison, H. J., see Gillis, A. M., 176 Meezan, E., see Pillion, D. J., 1274 vestigate the structure-activity Matsuda, Y., see Amano, K-I., 1359 Mehrke, G., Zong, X. G., Flockerzi, V. and profile of a series of novel opioid Matsumura, see Robertson, G. S., 1058 Hofmann, F.: The Ca-channeb , 795 Matsunaga, Y., see Yamamoto, 0., 1471 blocker Re 40-5967 blocks differ- Lutz, M. W., see Goetz, A. S., 1228 Mattana, J., Gibbons, N. and Singhal, P. ently T-type and L-type Ca4” Lymphatics, mesenteric, 5-HT2 and 5-HT4 channels, 1483 receptors in, in bovine, 379 C.: Cocaine interacts with macro- phages to modulate mesangial Meini, S., see Maggi, C. A., 1489 Machu, T. K and Harris, R. A.: Alcohols cell proliferation, 311 Meisch, R. A., see Stewart, R. B., 200 and anesthetics enhance the Matzno, S., Gohda, M., Eda, M., Ebisu, H., Melanocytes, chbereethylnitresourea-re- function of 5-hydrexytryptamine4 Uno, S., Ishida, N., Nakamura, N. sistant malignant, BNAG en- receptors expressed in Xenopus and Yamanouchi, K: A possible hancement of chioroethylnitro- laevis oocytes, 898 mechanism of action of a new po- seurea antitumor effects in, in Maciag, C. M., Logue, A. R., Tinker, W. J., tassium channel opener, AL0671, human, 1353 Saydoff, J. A., Tam, S. W. and on lipid metabolism in obese Melaragno, M. G., see Gorbea-Oppliger, V. Zaczek, R.: Studies on the role of Zucker rats, 1666 J., 804 K, Cl and Na ion permeabili- Maurizis, J. C., see Cussac, C., 1353 Meller, E. and Bohmaker, K: Differential receptor reserve for 5-HT, recep- ties on the acetylcholine release Mazzola-Pomietto, P., see AU1akh, C. S., tor-mediated regulation of enhancing effects of linopirdine 143 (DuP 996) in rat cerebral cortical plasma neuroendocrine her- McBurney, R. N., see Kirk, C. J., 1080 menes, 1246 slices, 891 MCC, see Methylcarbamylcholine Macbouf, J., see Patrignani, P., i705 Melvin, L., see Fan, F., 1383 McCall, R B., Escandon, N. A., Harris, L. Macrophages, interaction with cocaine, MEN 10,627, novel polycycic peptide an- T. and Clement, M. E.: Tolerance modulation of mesangial cells by, tagonist, 1489 development to the vagal-medi- 311 Mendelsohn, F., see Farrington, H., 1074 ated bradycardia produced by Madamba, S. G., see Nie, Z., 1566 Meng, Z.-H. and Dar, M. S.: Intrastriatal 5-HT receptor agomsts, 776 Madelmont, J. C., see Cussac, C., 1353 Ro15-4513 functionally antago- McCall, R. B., Romero, A. G., Bienkowski, Maeda, N., see Nomura, K, 100 nizes ethanol-induced motor inco- Maelicke, A., see Alkondon, M., 494 M. J., Harris, D. W., McGuire, J. ordination and striate.! adenosin- Magdalou, J., see Perrier, L., 91 C., Piercey, M. F., Shuck, M. E., ergic modulation of ethanol- Maggi, C. A., Astolfi, M., Giuliani, S., Smith, M. W., Svensson, K A., induced motor incoordination in Goso, C., Manzini, S., Meini, S., Schreuer, P.J.K.D., Carlsson, A. rats, 524 Patacchim, R., Pavone, V., Pe- and Vonvoigtlander, P. F.: Char- Merchant, K M., Dobie, D. J., Filboux, F. done, C., Quartara, L., Renzetti, acterization of U-92016A as a se- M., Totzke, M., Aravagiri, M. and A. R. and Giachetti, A.: MEN lective, orally active, high intrin- Dorsa, D. M.: Effects of chronic 10,627, a novel polycycic peptide sic activity 5-hydroxytryp- haloperidob and cbezapine treat- antagonist of tachykinin NK re- tamine agonist, 875 ment on neurotensin and c-fos ceptors, i489 McCarroll, L. A., see Doctrow, S. R., 229 mRNA in rat neostriatal subre- Magnesium, effects on ethanol inhibition McCarthy, A., see Knock, G. A., 1007 giens, 460 of NMDA-stimulated NO syn- McCook, E. C., see Wagner, J. P., 472 Mesangial cells, modulation by cocaine, thase in cortical neurons, 67 McDowell, K P., see Robinson, S. E., 1234 3i1 Magous, R., see Cuq, P., 149 McGinn, T. M., see Law, P. Y., 1686 Mesencephalic brain stimulation rein- Maher, J. R., see Robinson, S. E., 1234 McGrath, J. C., see Smith, G.C.S., 390 forcement, by nicotine, 294 Maines, M. D., see Ewing, J. F., 408 McGuire, G. M., see Liu, P., 438 Mesenteric arteries, Mn-DPDP- and Mn- Makhay, M. M., see Walker, E. A., 959 McGuire, J. C., see McCall, R. B., 875 C12-induced endothelium-depen- Male-specific cytechrome P450, over-ex- McGuire, J. J., Anderson, D. J. and Ben- dent relaxation in, in bovine, 609 pression by MSG, in adult rats, nett, B. M.: Inhibition of the bie- Mesenteric lymphatics, 5-HT2 and 5-HT4 1067 transformation and pharmacobog- receptors in, in bovine, 379 Mabfroy, B., see Doctrow, S. R., 229 ical actions of gbyceryb trinitrate Messam, C., see Desai, S., 220 Malik, K U., see Sehic, E., 983 by the flavoprotein inhibitor, di- Messenger RNA Manganese-C12-induced endethelium-de- phenyleneiodonium sulfate, 708 c-fos pendent relaxation, in bovine MC1-i86, effects on cerebral arachidonate effects efchronic antipsychotics on, in mesenteric arteries, 609 cascade, 1624 rat neostriatal subregions, 460 Manganese(II)-N,N’-dipyridoxylethyl- McNeilb, J. H., see Verma, S., 1334 protooncogene expression of, effects of enediamine-N,N’-diacetate-5,5’- mCPP, see m-Chlorophenylpiperazine thyroid hormone en, in develop- bis(phosphate)-induced endothe- M-current, regulation of, in sympathetic ing rat brain, 472 hum-dependent relaxation, in neurons, 581 D1 dopamine receptor antisense, inhibi- bovine mesenteric arteries, 609 McVicar, J. P., see Thummel, K E., 549, tion of D1 behaviors by, in mice, Mann, D., see Gelperin, D., 507 557 1462 1994 Index 1735

Mesulergine, effects on DOM neureendo- Mikus, G., see Cleary, J., 1528 Morrow, A. R., see Doctrow, S. R., 229 crine effects, in rats, i43 Mildenberger, S., see Gekbe, M., 1 Motilin, phase III contractions induced by, Metergoline, effects on DOM neuroendo- Millington, W. R., see Unal, C. B., 952 inhibition by pentagastrin, in crine effects, in rats, 143 Mironneau, C., see Lepretre, N., 1209 Heidenhain pouch dogs, 1471 Metformin, antihypertensive effects, in Mironneau, J., see Lepretre, N., 1209 Motilin receptors, EM574 agonistic pro- fructose-fed hyperinsulinemic hy- Misaki, M., see Yanai, S., 1267 file, in human gastric antrum, pertensive rats, 1334 Mishina, E. V., Binder, J., Kupiec-Weglin- 574 Methamphetamine ski, J. W. and Jusko, W. J.: Effect Motor incoordination, ethanol-induced, in- neurotoxicity to neostriatal DA neurons of liposomal methybprednisobone trastriatal Ro15-45i3 effects on, induced by, adenosine protection on heart albograft survival and in rats, 524 against, 1320 immune function in rats, 868 Mounetou, E., see Cussac, C., 1353 potentiatien ofcarbon tetrachloride hep- Mitochondrial fatty acid beta-oxidation Mey, T. M., see Hegde, S. S.,741 atotoxicity by, in mice, 1051 system, bioactivation of DCTH MEG, see Monosodium glutamate (3R,4S,5S,6R)-5-Methoxy4-[(2R,3R)-2- by, 515 Murakami, M., see Yodoya, E., 1509 methyl-3-(3-methyb-2-butenyl)px- Mittelman, G., Rosner, A. L. and Schaub, Muranishi, S., see Yodoya, E., 1509 iranyb]-i-oxaspiro-[2,5]oct-6-yl- C. L.: Pobydipsia and dopamine: Murehara, T., see Buerke, M., 134 (chloroacetyl)carbamate, see Behavioral effects of dopamine Murphey, L. J. and Olsen, G. D.: Diffusion TNP-470 Dl and D2 receptor agonists and of morphine-6-13-D-gbucuronide Methybcarbamybcholine, chronic, effects antagonists, 638 into the neonatal guinea pig brain on cortical nAChRs, 651 Miyahara, H., Kawai, Y. and Ohhashi, T.: during drug-induced respiratory N-Methyl-D-aspartate, ethanol inhibition 5-Hydroxytryptamine-2 and -4 depression, 118 of nitric oxide synthase stimu- receptors located on bovine iso- Murphy, D. L, see AUlakh, C. S., 143 lated by, in cortical neurons, 67 bated mesenteric bymphatics, 379 Murphy, R. C., see Wheelan, P., 1514 N-Methyl-D-aspartate receptors Mizuguchi, T., see Yamamoto, T., 156 Murray, L., see Zalcman, S., 977 alaproclate blockade, 1314 Mizushima, Y., see Igarashi, R., 1672 Muscarine, regulation of M-current in calcium channel effects [3H1-MK912, alpha-2C adrenoceptor sebec- sympathetic neurons by, 581 effects of prenatal ethanol exposure tivity, 1558 Muscarinic analgesia, spinal, mediation on, 1291 Mn-DPDP, see Manganese(II)-N,N’- by L-arginine/itric oxide/cyclic steroid modulation of, 677 dipyridoxylethylenediamine- GMP cascade, 601 inhibition by nitrendipine, in rodent cor- N,N’-diacetate-S,S’-bis(phos- Muscarinic receptors tical neurons, 30 phate) cecum circular smooth muscle cell sub- ionophores, in vitro neuroprotection by Molinoff, P. B., see Filtz, T. M., 1574 types, in rabbit, 149 substituted guanidines with af Monoamines, interactions in ventral teg- M2, contractile effects on ileum, inhibi- unity for, 1080 mental area, cocaine effects on, in tion by pertussis toxin, in guinea in naloxone-induced contractions, in rats, 1597 pig, 1042 guinea pig ileum after preincuba- Monocbonal antibody HuDREG-200, car- vascular, in guinea pig carotid arteries, tion with morphine, 1365 dioprotective effects in feline 1638 a,-Methylenadenosine-5’-triphosphate, myocardial reperfusion injury, Muscle effects on RNS-induced vasocon- 134 circular striction, 983 Monocytic THP-i cells, human, effects of muscariic receptor subtypes in, in 3,4-Methylenedioxymethamphetamine, prostacyclin analogs on, 446 rabbit cecum, 149 neurotoxic effects of, age medula- Monosialoganglioside NO inhibition of acetylcholine release tion of, 285 effects en haloperidob-induced behav- from, in canine ileum, 918 (S)-3-Methyl-5-(i-methyl-2-pyrrolidinyl) ioral supersensitivity, in rats, cobonic, effects ofsubstance P on, in rats, isoxazole, see ABT-418 1193 7 (3R,6R)-6-Methyl-5-oxo-3-thiomorpholi- effects on neonatal hypoxia, 1299 smooth nylcarbonyl-L-histidyl-L-prolin- Monosodium glutamate, over-expression calcium channels in, inhibitory effects amide tetrahydrate, see NS-3 of CYP2C11 by, in adult male of isoflurane on, in guinea pig 3-Methyl-1-phenyb-pyrazolin-5-one, see rats, 1067 portal vein, 1159 MC1-186 Moore, K E., see Goudreau, J. L., 1000 potassium currents in, modulation by Methylprednisolone, liposomal, effects on Morgan, K G., see Doctrow, S. R., 229 NS-004, in canine coronary ar- heart allograft survival in rats, Morgan, P. H., see Lutz, M. W., 795 tery, 362 868 Morice, A. H., see Zhang, F., 326 vascular cells [5R-(5,7,813)]-N-Methyl-N-[7-(i-pyrrolidi- Merizawa, Y., see Igarashi, R., 1672 inhibition by U-86983, in rat, 415 nyl)i-oxaspiro(4,5)dec-&yl}-4- Morphine mediation by AT1 receptors, in rat, benzofuranacetamide, see Cl-977 discriminative stimulus and analgesic 429 M6G, see Morphine-6--D-g1ucuronide effects of, in vivo apparent pA Mushiroi, T., see Itoh, Y., 884 , effects on DOM neuroendo- analysis with naltrexone for, in Musso, G. F., see Doctrow, S. R., 229 crine effects, in rats, 143 rats, 959 Myebegenous leukemia, chronic, cloning Miao, C. K, see Farina, P. R., 1418 naboxone-induced contractions after pro- TXA2 receptors from human Microdialysis, study of cocaine effects on incubation with, NMDA receptors K562 cells from, 1034 monoamine interactions in yen- in, in guinea pig ileum, 1365 Myebeid cells, effects of cycbopentenone tral tegmental area, in rats, 1597 Morphine-6--D-glucuronide, diffusion prostaglandins during early Microsomes, hepatic, N-glucuronidation of into neonatal brain during drug- HTLV-I infection on, 1086, 1096 SR47436 by, in rat, monkey and induced respiratory depression, Myebomonocytic cell lines, comparison of human, 91 in guinea pig, 118 retinoid and VD3 analog effects Microvascubar endothelial cells, RMP-7 ef- 2-(4-Morpholino)ethyl 1-phenylcycbohex- on, 193 fects on intracellular free calcium ane-1-carboxybate hydrochloride, Myenteric neurons, bradykiin effects on levels in, in rat brain, 229 see PRE-084 cytosolic calcium in, in rat, 507 Midazobam 3-Morpholinosydnonimine-N-ethylcarb- Myers, A. K, see Williams, J. K, 671 as human CYP3A probe, 549, 557 amide, see SIN-i Myocardial ischemia-reperfusion injury self-administration, in rhesus monkeys, 2-(4-Morpholinyl)-8-(3- cardioprotective effects of mAb Hu- 200 pyridinybmethoxy)4H-1-benzopy- DREG-200 in, in feline, 134 Midline mesencephalic brain stimulation ran-4-one, see U-86983 H3 receptors in, 1259 reinforcement, by nicotine, 294 Morris, J., see Erickson, L. A., 415 Myocytes 1736 Index Vol. 271

portal vein, electrophysiobogical and ra- chemical and electrophysiobogical MCC-induced up-regulation of, 651 dioligand binding studies of elgo- mechanisms of the positive ine- Nie, Z., Madamba, S. G. and Siggins, G. R.: dipine in, 1209 tropic effect of calyculin A, a pro- Ethanol inhibits gbutamatergic ventricular tein phosphatase inhibitor, 535 neurotransmission in nucleus ac- chborpromazine inhibition ofK chan- Neureactive steroids, anticonvulsant ef- cumbens neurons by multiple nels in, in rat, 632 fects of, sensitivity to, during es- mechanisms, 1566 rate-dependent APD prolongation by true cycle, 164 Nigrostriatab lesions, 6-OHDA, SKF 38393 sematilide in, in guinea pig, 302 Neurcendecrine hormones, mediation by effects on basal gangbia output NAChR, see Nicotiic receptors 5-HT1A receptors with, in rats, 1434 Nadeau, M., see Farina, P. R., 1418 differential receptor reserve for, 1246 Niiya, K, Uchida, S., Tsuji, T. and Olsson, Nakamura, N., see Matzno, S., 1666 effects of prenatal cocaine exposure en, R. A.: Glibenclamide reduces the Nalbuphine in male vs female rat progeny, coronary vasoactivity of adeno- antinociceptive and respiratory effects, 1453 sine receptor agonists, 14 in rhesus monkeys, 993 Neurokinin1 receptors, mediation of 6-ke- Nitrendipine, reduction ofNMDA currents discriminative stimulus and analgesic tOPGFia release from canine ib- by, in rodent cortical neurons, 30 effects of, in vivo apparent pA eum by, 39 Nitric oxide analysis with naltrexone for, in Neurokinin2 receptors, pobycycic peptide effects on chronic granulomatous colitis, rats, 959 antagonist MEN 10,627, i489 1114 Naloxone Neurobeptics, Foe expression induced by, inhibition of acetylcholine release from contractile effects after preincubation 1058 circular muscle nerves by, in ca- with morphine, NMDA receptors Y nine ileum, 918 in, in guinea pig ileum, 1365 inhibition ofnicotinic receptor-mediated mediation of capsaicin antinociceptive multiple indices of opiate withdrawal chromaffin cell secretion by, 61 effects by, in adult mouse, 1281 precipitated by, 1391 vascular contents, effects of chronic nic- mediation of spinal muscariic analge- Naltrexone, in vivo apparent pA analysis otine on, in rats, 1135 sia by, 601 with, for discriminative stimulus Neuroprotectien, in vitro, by substituted release of, enhancement by furosemide, and analgesic effects of opiate guanidines, i080 1611 agonists, in rats, 959 Neurosteroids, modulation of NMDA re- Nitric oxide donor relaxations, effects of Nambi, P., see Brooks, D. P., 769 ceptor-induced increases in intra- K’ channel blockers on, in guinea Nambi, P., see Ohlstein, E. H., 762 cellular Ca by, 677 pig trachea, 782 Nambi, P., Elshourbagy, N., Wu, H.-L., Neurotensin, effects of chronic antipsy- Nitric oxide synthase Pulben, M., Ohbstein, E. H., chotics on, in rat neostriatal sub- effect of endotoxin challenge on, in rat Brooks, D. P., Lago, M. A., Effiott, regions, 460 cobonic epithelial cells, 1477 J. D., Gleason, J. and Ruffobo, R. Neurotensin receptors, intestinal, in inhibition of, effects on chronic granule- R., Jr.: Nonpeptide endothelin re- guinea pig, 267 matous colitis, 1114 ceptor antagonists. I. Effects on Neurotoxicity inhibitor effects on substance P activa- binding and signal transduction MDMA, age modulation of, 285 tion of cobonic motility, in rats, 7 on human endethelinA and endo- to neostriatal DA neurons, METH-in- NMDA-stimubated, ethanol inhibition thelinB receptors, 755 duced, adenosine protection of, in cortical neurons, 67 Namiki, T., see Sawanobori, T., 302 against, 1320 regulation of gastric emptying of solid Nance, D. M., see Zalcman, S., 977 Neurotransmission meals by, 660 Nartograstim, pharmacokinetics, in rats, gbutamatergic, ethanol inhibition of, in Nitroprusside, vasorelaxant effects of, ef- monkeys and humans, 1535 nucleus accumbens, i566 fects of in vitro hypoxia en, in rat Natoli, C., see Patrignani, P., 1705 neonatal hypoxia-associated, 1299 pulmonary arteries, 845 Natural killer cells, splenic, effects of Neutrophils, BIRM 270 inhibition of NMDA, see N-Methyb-D-aspartate acute ethanol on, in mouse, 722 arachidonate release in, in hu- Noble, F., Smadja, C. and Roques, B. P.: Neff, N. H., see Krajnc, D., 1299 man, 1418 Robe of endogenous cholecystoki- Neointima, reduction by U-86983, 415 NG1O8-i5 cells, ethanol-induced changes nin in the facilitation of mu-me- Neonatal hypoxia, GM1 ganglioside effects in, mediation by adenosine recep- diated antinociception by delta- on, 1299 tore, 542 opioid agonists, 1127 Neonates Nickel, inhibition ofET contractile effects, Neciception, spinal and thermal, effects of MSG exposure, over-expression of in rabbit aorta, 1223 ET-A and ET-B receptors on, 156 CYP2C11 in adult male rats af- Nicosia, S., see Wheelan, P., 1514 Nodose ganglion neurons, 5-HT-induced tar, 1067 Nicotine inward current in, cocaine effects respiratory depression, drug-induced, chronic on, in, 262 M6G diffusion into brain during, effects on nicotine sensitivity, 125 Nomura, K, Maeda, N., Yoshino, T. and in guinea pig, i18 effects on peripheral vascular reactiv- Yamaguchi, I.: A mechanism of ventricular cells, alpha-i adrenergic ity, in rat, 1135 5-hydroxytryptamine3 receptor modulation of 1-type calcium reinforcement effects, 294 mediation is involved etiobogi- channels in, in rat, 935 sensitivity to, effects of chronic nicotine cally in the psychological stress intracellular mechanisms of, 944 and mecamybamine infusion on, lesion in the stomach of the Neostriatum i25 mouse, 100 dopaminergic neurons, adenosine pro- Nicotinic receptors Nonadrenergic, noncholinergic contrac- tection against METH-induced agenists, intrathecal, stimubatory path- tions, effects of PDE inhibitors neurotoxicity to, 1320 ways and sites of action of, 1550 on, in guinea pig bronchus, 811 subregions, effects of chronic antipsy- brain, sensitivity to, effects of chronic Nonadrenergic, nonchelinergic relax- chetics on neurotensin and c-los nicotine and mecamylamine infu- atiens, effects of K channel mRNA in, in rat, 460 sion on, i25 blockers on, in guinea pig tra- Nephrotoxicity, DCTH, 515 chromaffin cell secretion mediated by, chea, 782 Nettleton, D. 0., see Tramposch, K M., NPY inhibition of, 61 Non-NMDA receptor antagonists, anticon- 852 cortical, effects of chronic MCC on, 65i vulsant activity, 25 Neubig, R. R., see Uhb#{233}n,S., 1558 (±)-epibatidine mediated by, biological Nonpeptide antago- Neumann, J., BoknIk, P., Herzig, S., effects of, 624 nists Schmitz, W., Scholz, H., Wiechen, hippocampal, subunits and diversity of, effects on acute renal failure, in anes- K and Zimmermann, N.: Bie- in rat, 494 thetized dogs, 769 1994 Index I 737

effects on ET-i binding to human ETA II. Pharmacological characteriza- rat receptors differ from the hu- and ETB receptors, 755 tion of SB 209670, 762 man and porcine receptors, 735 pharmacological characterization of, Ohno, A., see Beck, F. X., 403 Oshita, M., Takei, Y., Kawano, S., 762 Ohshima, K, see Satoh, M., 574 Fusamoto, H. and Kamada, T.: Nonsteroidal anti-inflammatory drugs, in- OK cells, see Opossum kidney cells Protective effect of ebselen on hibitien of hPGHS-i and -2 by, Okada, H., see Yanai, S., 1267 constrictive hepatic vascubature: 927 Oligodeoxynucleotide antisense, D1, inhi- Prevention of alcohol-induced ef- Nordidemnin, effects on WRK cells, 107 bition ofD1 behaviors by, in mice, fects on portal pressure in per- Norepinephrmne 1462 fused livers, 20 exocytotic release, regulation by H3 re- Olsen, G. D., see Murphey, L. J., 118 Osmanovic, S. S. and Shefner, S. A.: Eth- ceptors, i259 Olsson, R. A., see Niiya, K, 14 anol enhances inward rectifica- release in carotid artery, modulation by Omoniyi, A. T., see Imamura, M., i259 tion in rat locus cerubeus neurons muscariic receptors, in guinea Omura, S., see Satoh, M., 574 by increasing the extracellular pig, 1638 Ondansetron, effects on DOM neuroende- potassium concentration, 334 vascular contents, effects of chronic nic- crine effects, in rats, i43 Overdose, cocaine, cocaine binding sites en otine on, in rats, ii35 dopamine transporter in, 1678 O’Neill, A., see Brioni, J. D., 353 NPC 16377, see 6-[6-(4-Hydrexypiperidi- Owen, M. D., see Unal, C. B., 952 Oocytes, X laevis, 5-HT3 receptors ex- nyl)-hexoxy]-3-methyfflavone hy- Oxycodene, analgesic effects, effects of pressed in, effects of alcohols and drochboride pharmacogenetics on, in Sprague- anesthetics on, 898 NS-3, effects on acetybcholine release in DawleyfDark Agouti rat, 1528 Opieid receptors rat brain, 884 Ozaki, H., see Amano, K-I., 1359 delta NS-004, modulation of K currents by, in pA2 analysis, in vivo apparent, with nal- canine coronary artery smooth binding in brain, in monkey, 1630 trexone, for discriminative stimu- muscle cells, 362 density and activity, in Chinese ham- ster ovary cells, 1686 bus and analgesic effects of opiate NSAIDs, see Nonsteroidal anti-inflamma- agonists, in rats, 959 tory drugs mu interactions, robe of CCK in, 1127 Pacheco, M., see Filtz, T. M., i574 NSC 639366, inhibition of angiegenesis kappa Pagani, E. D., see Silver, P. J., 1143 by, 1027 agonist antinociceptive effects, in Pagannone, S., see Prisco, S., 83 Nucleoside transporters, liposome-recon- squirrel monkeys, 1501 Palmer, M. R., see Lin, A.M.-Y., 1175 stituted, functional and pharma- agonist antinociceptive effects against Pampori, N. A. and Shapiro, B. H.: Over- cobogical characteristics of, 906 inflammation, 1306 expression of hepatic male-spe- Nucleosides, o substituted, enhancement binding in brain, in monkey, 1630 cific form of cytochrome P450 in of chboroethylnitrosourea antitu- mu the presence of nominal pulses of mor effects by, in chboroethylni- antagonists, in combination with circulating growth hormone in trosourea-resistant human ma- kappa opioid agonists, antineci- adult male rats neonatally ex- lignant mebanocytes, i353 ceptive effects, in squirrel men- posed to low levels of meneso- Nucleotide transport, in liposomes, 906 keys, iSOi dium glutamate, 1067 Nucleus accumbens binding in brain, in brain, 1630 Panara, M. R., see Patrignani, P., 1705 cocaine effects on mesolimbic dopamine cbocinnamox effects on binding and Pang, P.KT., see Liu, Q.-Y., 935, 944 neurons in, antagonism by analgesia of, 715 Parks, T. P., see Farina, P. R., i4i8 GBR12909, in rat, 1216 delta interactions, role of CCK in, Parrish, M. B., Rainsford, K D., Johnson, ethanol inhibition of glutamate in, 1566 1127 D. M. and Daniel, E. E.: NK re- sigma, see sigma receptors 06 substituted nucleosides, enhancement ceptors mediated release of 6-ke- Opioids of chioroethylnitrosourea antitu- te-PGF1a from the ax vivo per- mor effects by, in chboroethybni- analgesic effects fused canine ileurn, 39 trosourea-resistant human ma- effects of pharmacogenetics on, in Parsons, H. G., see Gillis, A. M., 176 lignant melanocytes, 1353 Sprague-Dawley/Dark Agouti rat, Pasnani, J. S. and Ferrier, G. R.: Pro- and Obesity, effects ofALO67i on lipid metab- 1528 antiarrhythmic effects of d-se- olism in, in Zucker rats, 1666 pharmacodynamic model of, 795 tabob and dl-sotalol in an isolated Ochiai, A., see Igarashi, R., 1672 sigma antagonism of, 1583 tissue model of ischemia and Ochratoxin-A, effects on protein uptake in drug discrimination assessment in hu- reperfusion, 184 proximal tubule-derived opossum mans, three-choice saline-hydro- Pasternak, G. W., see Chien, C-C., 1583 kidney cells, 1 morphone-butorphanol proce- Patacchini, R., see Maggi, C. A., 1489 Ocular insulin, topical, absorption-en- dure, 48 Patino, N., see Dominice, C., 107 hancing effects of alkylgbycosides naloxone-precipitated withdrawal, mul- Patrignani, P., Panara, M. R., Greco, A., on, in rat, 1274 tiple indices of, 1391 Fusco, 0., Natoli, C., lacobelli, S., Ocvirk, A., see Krisch, I., 343 Opossum kidney (OK) cells, proximal tu- Cipeilone, F., Ganci, A., Cr#{233}mi- ODonnell, J. M., Frith, S. and Wilkins, J.: bube-derived, endocytosis in, 1 non, C., Macbouf, J. and Patrono, Involvement of beta-i and beta-2 Oral reinforcers, benzediazepine, in rho- C.: Biochemical and pharmaco- adrenergic receptors in the anti- sue monkeys, 200 logical characterization of the cy- depressant-like effects of cen- Organic anions, multiple biliary excretion cbooxygenase activity of human trally administered isoproterenol, systems, in rats, 370 bleed prostaglandin endoperoxide 246 Oriental subjects, metabolic disposition of synthases, i705 Ogasawara, T., see Itoh, Y., 884 imipramine in, 860 Patrono, C., see Patrignani, P., 1705 Ogawa, Y., see Yanai, S., 1267 Orihata, M. and Sarna, S. K: Inhibition of Paul, S. M., see Irwin, R. P., 677 6-OHDA, see 6-Hydroxydopamine nitric oxide synthase delays gas- Pavone, V., see Maggi, C. A., 1489 Ohhashi, T., see Miyahara, H., 379 tric emptying of solid meals, 660 Paw withdrawal latency, decrease in, Ohlstein, E. H., see Brooks, D. P., 769 Ornithine decarboxylase, effects of thyroid blockade by spinal GABAA recep- Ohbstein, E. H., see Nambi, P., 755 hormone on, in developing rat tor antagonists, in rats, 76 Ohistein, E. H., see Sung, C.-P., 429 brain, 472 PC12 cells, alpha-2B adrenoceptor precou- Ohlstein, E. H., Beck, G., Douglas, S. A., O’Rourke, M. F., Iversen, L. J., Lomasney, pling with G-proteins in, i520 Nambi, P., Lags, A., Gleason, J. J. W. and Bylund, D. B.: Species PD i2i98i, unmasking of angiotensin II G., Ruffobo, R. R., Jr., Feuerstein, orthobogs of the alpha-2A adren- bow concentration effects by, in G. and Elliott, J. D.: Nonpeptide ergic receptor: The pharmacobog- rabbit abdominal aorta, i59i endothelin receptor antagonists. ical properties of the bovine and Pedone, C., see Maggi, C. A., 1489 1738 Index Vol. 271

Pentagastrin, inhibition of motilin-in- insulin applied topically to the rat Potassium duced phase III contractions by, eye, 1274 extracellubar increase in, by ethanol, en- in Heidenhain pouch dogs, 1471 Pinacidib, vasorebaxant effects of, effects of hancement ofinward rectification in vitro hypoxia on, in rat pulmo- in rat locus ceruleus neurons by, effects on opioid analgesia, 1583 nary arteries, 845 334 regulation of striatal dopamine release i-Piperazinecarboxamide derivatives, levcromakalim effects on pulmonary ar- by, in rat, 2i2 FG5803, preclinical pharmacol- tery contractions induced by, in Pepelnak, M., see Krisch, I., 343 ogy, 1338 rat, 326 Periarterial nerve stimulation-induced re- 3-(Piperidine-i-yb)propyl-4-amine-5- Potassium channel blockers nal vasoconstriction, a,mATP chloro-2-methoxybenzoate hydro- effects on coronary vasoactivity of aden- effects on, 983 chloride, see RS-23597-i90 osine receptor agonists, i4 Periventricular-hypophysial dopaminergic Pirexicam, inhibition of hPGHS-i and -2 effects on NANC and NO donor relax- neurons, GABA receptor media- by, 927 ations in guinea pig trachea, 782 tion of, 1000 Pitts, R. C. and Dykstra, L. A.: Antinoci- Potassium channel openers Perkins, J. D., see Thummel, K E., 549, ceptive and response rate-alter- ALO671, effects on lipid metabolism in 557 ing effects of kappa-opioid age- obese Zucker rats, 1666 Perrier, L., Bourri#{233}, M., Marti, E., Tron- nists, , Cl-977 and vasorelaxant effects of, effects ofin vitro quet, C., Masse, D., Berger, Y., U69,593, alone and in combina- hypoxia on, in rat pulmonary ar- Magdalou, J. and Fabre, G.: In tion with opioid antagonists in teries, 845 vitro N-glucuronidation of SR squirrel monkeys, 1501 Potassium channels 47436 (BMS 186295), a new AT1 PKC, see Protein kinase C effects in release enhancement by li- nonpeptide angiotensin II recep- PLA, see Phospholipase nopirdine, in rat cerebral cortical tor antagonist, by rat, monkey Placentae, AT1 binding sites in, 1007 slices, 89i and human hepatic microsomal Plaque-forming cell responses, antigen- inhibition by chborpromazine, in rat yen- fractions, 91 specific 1gM, sympathetic media- tricubar myocytes, 632 Perry, M. R., see Hegde, S. S.,74i tion of IL-2 effects on, 977 modulation by NS-004, in canine core- Pertussis toxin Plasma nary artery smooth muscle cells, effects on [3HIRAU binding to alpha-2B ANP bevels, after acute alcohol, in rats, 362 adrenoceptors in PC12 cells, 1520 1656 M-type, regulation of, in sympathetic inhibition of M2-induced contractions of cocaine and benzoylecgnonine levels, neurons, 581 ileum by, in guinea pig, 1042 maternal and fetal, after acute Potter, G. S., see Gorbea-Oppliger, V. J., Petit, R. L., see Gorbea-Oppliger, V. J., 804 maternal iv administration of co- 804 Pettersson, E., see Bj#{246}rk,A., 1338 caine, in rat, 1234 PRE-084, regulation of dopamine release Pettersson, G., see Bj#{246}rk,A., i338 neuroendecrine hormones, regulation by from rat striatum by, 212 Pettersson, K, see Cheng, C-P., 1409 5-HT1A receptors, differential re- Preeclampsia, AT1 binding sites in placen- Pharmacogenetics, effects en opioid anal- ceptor reserve for, 1246 tae from pregnancies with, 1007 gesia, in Sprague-Dawley/Dark Plasticity, in Di agonist modulation of Pregnancy, AT1 binding sites in placentae Agouti rat, 1528 basal ganglia output, 1434 from, 1007 PRDA neurons, see Periventricular-hy- Platelet-activating factor Pregnenobone sulfate, modulation of pophysial depaminergic neurons biosynthesis of NMDA receptor-induced in- Phencycidine, deficits in sensorimotor effects of PLA inhibitors en, 852 creases in intracellular Ca by, gating efstartle response induced inhibition by BIRM 270, in human 677 by, cbozapine effects on, 787 neutrophils, 1418 2-Phenyb-i,2-benzisoselenazol-3-(2H)-one, picomobar, platelet activation by, 824 Premenopausal monkeys, effects of estro- see Ebselen Platelets gen on cardiovascular responses Phenylbutazone, inhibition of hPGHS-i activation by picomolar PAF, 824 in, 671 and -2 by, 927 cGMP inhibition of, in ischemia-reperfu- Prepulse inhibition, PCP-induced disrup- Phosphatase inhibitors, protein, calyculin sion injury, in rats, 1203 tion of, cbozapine effects on, 787 A, cardiac effects, 535 Pocidalo, J.-J., see Thueng-Guyot, M., Pressley, J. C., see Lutz, M. W., 795 Phosphodiesterase inhibitors, isozyme-se- 1544 Preston, K L and Bigebow, G. E.: Drug bective, effects on NANC contrac- Podoll, T., see Thummel, K. E., 549, 557 discrimination assessment of ag- tions, in guinea pig bronchus, 811 Polak, J. M., see Knock, G. A., 1007 onist-antagonist epieids in hu- Phosphodiesterase N inhibitors, suppres- Poli, E., see Imamura, M., 1259 mans: A three-choice saline-hy- sion of human eosinophil respira- Polycyclic , MEN iO,627 antago- dromorphone-butorphanol tory burst and cAMP hydrolysis nist, 1489 procedure, 48 by, ii67 Polydipsia, schedule-induced, dopamine Prior, T., see Rangachari, P. K, 1016 Phosphoinositide, nordidemnin inhibition effects on, 638 Prisco, S., Pagannone, S. and Esposito, E.: of, in WRK cells, 107 Polyphosphoinositides, inhibition by ta- Serotonin-dopamine interaction Phesphoinositide hydrolysis, in contractile moxifen, in GH4C1 cells, 238 in the rat ventral tegmental area: effects of guinea pig tracheal Pom#{233}s,A., RodrIguez-Farr#{233}, E. and Su#{241}ol, An ebectrophysiebogical study in 5-HT2A receptors, 832 C.: Disruption of GABA-depen- vivo, 83 Phospholipase A inhibitors dent chloride flux by cyclodienes Procainamide, pharmacodynamics, effects effects on beukotriene, prostaglandin and hexachlorocycbohexanes in ofdietary fat en, in rabbit hearts, and PM’ biosynthesis, 852 primary cultures of cortical neu- 176 topical anti-inflammatory effects, 852 rons, 1616 , plasma, regulation by 5-HT Phospholipase C, inhibition by tamoxifen, Portal pressure, hepatic, prevention of al- receptors, differential receptor re- in GH4C1 cells, 238 cohol-induced effects on, 20 serve for, 1246 Piattoni-Kaplan, M., see Sullivan, J. P., Portal vein Propofob, effects on 5-HT3 receptors, 898 624 myocytes, ebectrophysiebegical and ra- Propranobol, effects en DOM neuroende- Picomolar platelet-activating factor, plate- dioligand binding studies of elge- crine effects, in rats, 143 let activation by, 824 dipine in, 1209 Prostacycin Piercey, M. F., see McCall, R. B., 875 smooth muscle cells, inhibitory effects of analog effects on human monocytic Piffien, D. J., Atchison, J. A., Wang, R.-X. iseflurane en Ca channels in, THP-i cell function, 446 and Meezan, E.: Alkylglycesides in guinea pig, 1159 release of, enhancement by furosemide, enhance systemic absorption of Porter, A. C., see Uhl#{233}n,S., 1558 1611 1994 Index 1739

Prostaglandin endoperoxide synthases, Radiobigands Reserpine, SKF 38393 effects on basal human blood, characterization of, alpha-2 adrenergic [3H]-MK912, at- ganglia output with, in rats, 1434 1705 pha-2C selectivity of, 1558 Respiration, nalbuphine, in rhesus men- Prostagbandin F2,,, pulmonary artery con- binding of, effects of elgodipine on, in keys, 993 tractiens induced by, bevcro- portal vein myocytes, 1209 Respiratory burst, eosinophil, PDE N in- makaliin effects on, in rat, 326 Rainsford, K D., see Parrish, M. B., 39 hibitor effects on, in human, 1167 6-keto-Prostaglandin Fia, release from ca- Raisys, V. A., see Thummel, K E., 549 Respiratory depression, drug-induced, dif- nine ileum, NK1 receptor media- Raju, W. S., see Ewing, J. F., 408 fusion of M6G into neonatal tion of, 39 Rakotoarisea, L., see Lepretre, N., 1209 guinea pig brain during, 118 Prostaglandin H synthase, human Ramwell, P. W., see Williams, J. K, 671 Retinoids, effects on myeloid cells, corn- isozymes hPGHS-i and -2, inhibi- Randall, P. K, see Lee, Y.-H., 129i parison with VD3 analog effects, tion by NSAIDs, 927 Rangachari, P. K and Prior, T.: Func- i93 Prostaglandin receptors tional subtyping of histamine re- Rhim, B. Y., see Hong, K W., 1591 antagonists, inhibition of cremophor ceptors on the canine proximal co- Rice, K C., see Baumann, M. H., i2i6 vascular effects by, 730 bonic mucosa, 1016 Ries, M., Wenzeb, U. and Daniel, H.: dilator, in fetal rabbit ductus arteriosus, Rapp, M., see Cussac, C., 1353 Transport ofcefadroxil in rat kid- 390 Rattan, S., see Shibamoto, T., 277 ney brush-border membranes is Prostaglandins Raucy, J. L., see Daikh, B. E., 1427 mediated by two electrogemc W- biosynthesis of, effects of PLA inhibi- Rauwolscine, binding to alpha-2B adreno- coupled systems, 1327 tors on, 852 ceptors, effects of pertussis toxin Rimebe, T. J., see S., 1228 cycbopentenene Goetz, A. on, in PC12 cells, 1520 RINm5F rat beta-cell line, amitraz inhibi- effects on myeboid cells during early Recombinant human granubocyte colony- tion of insulin release in, 1240 HTLV-I infection, i086, 1096 regulation of HSP7O by, 1096 stimulating factor, pharmacoki- Ritanserin, effects on DOM neuroendo- crime effects, in rats, 143 mediation of calcium influx by, 507 netics, in rats, monkeys and hu- Prostate membranes, alpha-adrenoceptor mans, 1535 Ritchie, D. M., see Argentieri, D. C., 1399 Rittenhouse, P. A., Bakkum, E. A., Levy, subtypes in, in human and ca- Rectal balloon distension, hypogastric nine, 1228 nerve effects in, in opossum, 277 A. D., Li, Q., Carnes, M. and Van Protein kinase C Rectoanal inhibitory reflex, hypogastric de Kar, L. D.: Evidence that regulated by in contractile effects of guinea pig tra- nerve effects in, in opossum, 277 ACTH secretion is serotonin2 (541T1.vaC) recep- cheal 5-HT2A receptors, 832 Reddy, N. L., see Kirk, C. J., 1080 tore, 1647 mediation of EGF-induced i2-lipoxyge- Reflex, rectoanal inhibitory, hypogastric nase expression in A431 cells by, nerve effects in, in opossum, 277 RMP-7 B2 receptor activation by, in rat brain 567 Regiosebectivity, of P450 2C8 and 2C9 ep- microvascular endothelial cells, Protein phosphatase inhibitors, cardiac ef- oxidation of arachidonic acid, fects, 535 1427 229 effects on intracellular free calcium 1ev- Proximal tubule-derived opossum kidney Reinforcement els in rat brain microvascular en- cells, endocytosis in, 1 nicotine, 294 dothelial cells, 229 Pruett, S. B., see Wu, W.-J., 722 oral, benzediazepine, in rhesus men- RO-20i724, effects on NANC contractions, Psychological stress lesions, gastric, 5-HT3 keys, 200 in guinea pig bronchus, 811 receptor effects in, in mouse, 100 Reinhardt, S., see Alkondon, M., 494 RoiS-45i3, intrastriatal, effects on etha- Pucak, M. L. and Grace, A. A.: Evidence Reinlib, L., see Farrington, H., 1074 nob ataxia in rats, 524 that systemically administered Reith, M.E.A., see Chen, N.-H., 1597 Re40-5967, T-type and L-type Ca -chan- dopamine antagonists activate Reith, M.E.A. and Coffey, L. L.: Structure- nel blockade by, 1483 dopamine neuron firing primarily activity relationships for cocaine by blockade of somatodendritic Roache, J. D., see Stewart, R. B., 200 congeners in inhibiting dopamine Roberts, S. M., Harbison, R. D. and James, autoreceptors, 1181 uptake into rat brain synaptic Puglianiello, A., see Lacal, P. M., 1086 R. C.: Methamphetamine potenti- vesicles and bovine chromaffin ation of carbon tetrachboride hep- Pullen, M., see Nambi, P., 755 granule ghosts, 1444 atotoxicity in mice, 1051 Pulmonary artery Relaxation, see also Vasodilatien S., Matsumura, H. and contraction of, effects of levcromakalim Robertson, G. endothelium-dependent, Mn-DPDP- Fibiger, H. C.: Induction patterns on, in rat, 326 and Mn-Cb2-induced, in bovine of Foe-like immunoreactivity in vasorebaxation of, effects of in vitro hy- mesenteric arteries, 609 poxia on, in rat, 845 the forebrain as predictors of NANC and NO donor, effects of K atypical antipsychotic activity, Purand, K, see Ligneau, X., 452 channel blockers on, in guinea pig i058 Purdy, R. H., see Irwin, R. P., 677 trachea, 782 Robinson, S. E., Enters, E. K, Jackson, G. Purkinje neurons, cerebeblar, ethanol-in- Renal failure, acute, effects of SB 209670 duced depressions of, 13-adrener- F., Chinchibli, V. M., Maher, J. R., and BQ123 on, in anesthetized McDowell, K P., Allen, H. M. and gic modulation of, in rat, 1175 (5a,7a,8f3)-(+)-N-[7-(i-Pyrrolidinyl)-i- dogs, 769 Guo, H.: Maternal and fetal brain oxaspiro(4,5)dec-8-yb}benzeneac- Renal nerve stimulation-induced vasocon- and plasma levels of cocaine and striction, aJ3mATP effects on, 983 benzoylecgonine after acute or etamide, see U69,593 Ream, mediation by 5-HT receptors, ef- chronic maternal intravenous ad- Quadazocine, in combination with kappa fects of prenatal cocaine exposure ministration of cocaine, 1234 opioid agonists, antinociceptive on, in male vs female rat progeny, Rodrfguez-Farre, E., see Porn#{233}s,A., 1616 effects, in squirrel monkeys, 1501 1453 Rogawski, M. A., see Donevan, S. D., 25 Quartara, L., see Maggi, C. A., i489 Renzetti, A. R., see Maggi, C. A., 1489 Rogawski, M. A., see Irwin, R. P., 677 Que, B. G., see Crutchbey, D. J.,446 Reperfusion injury Rolipram Queen, C., see Buerke, M., 134 antiplatelet effects of cGMP in, in rats, effects on NANC contractions, in guinea Quinidine, pharmacodynamics of, effects 1203 pig bronchus, 811 of dietary fat en, in rabbit hearts, arrhythmias, sotalol effects on, 184 suppression of superoxide anion genera- 176 hepatic, reduction by U-74006F, 438 tion by, 1167 Quinobones, chondrotoxicity in vitro, 1544 myocardial Romero, A. G., see McCall, R. B., 875 Quinpirobe, behavioral effects, 638 cardioprotective effects of mAli Hu- Rorney, G. and Lazdunski, M.: Effects of a DREG-200 in, in feline, 134 new class of calcium antagonists, Rabe, K F., see Dent, G., 1167 H3 receptors in, 1259 SR33557 (fantofarone) and 1740 Index Vol. 271

SR33805, on neuronal voltage-ac- Scholz, H., see Neumann, J., 535 tolerance to vagal bradycardic effects tivated Ca4 channels, 1348 Schreuer, P.J.KD., see McCall, R. B., 875 of, 776 Roques, B. P., see Noble, F., 1127 Schroder, H., see Schr#{246}der, U., 1193 U-920i6A properties, 875 Rosenthale, M. E., see Argentieri, D. C., Schr#{246}der, U., Schr#{246}der, H., Augustin, W. effects of prenatal cocaine exposure en, 1399 and Sabel, B. A.: Haloperidol-in- in male vs female rat progeny, Rosner, A. L., see Mittelman, G., 638 duced behavioral supersensitivity i453 Rotkman, R. B., see Baumann, M. H., 1216 is increased by menesialoganglie- regulation of bleed hormones by, differ- RS-23597-i90, binding to sigma-i sites in side treatment in rats without a!- ential receptor reserve for, 1246 guinea pig brain, 484 fecting spiroperidol-binding, 1193 Serotonin receptors Ruan, Y., see Sehic, E., 983 Schulteis, G., Markou, A., Gold, L. H., Sti- cloned, expressed in fibroblasts, mCPP Ruifolo, R. R, Jr., see Brooks, D. P., 769 nus, L. and Koob, G. F.: Relative and TFMPP agonists, 1122 Ruffobo, R. R., Jr., see Nambi, P., 755 sensitivity to naloxone of multiple contractile effects in guinea pig trachea, Ruffobo, R. R., Jr., see Ohistein, E. H., 762 indices of opiate withdrawal: A 832 Rundown, ofnAChR whole-cell currents in quantitative dose-response analy- Serotonin3 receptors hippocampal neurons, in rat, 494 sis, 1391 cocaine effects on, in rat nodose ganglion Ruttenber, A. J., see Staley, J. K, 1678 Schultz-Dale response, in guinea pig lung neurons, 262 RWJ-20485, see Tepoxalin parenchyma, 615 effects in psychological stress lesions in Sabel, B. A., see Schr#{246}der, U., 1193 Schunack, W., see Ligneau, X., 452 stomach, in mouse, 100 Saito, H., see Sugiura, M., 703 Schuster, S. V., see Lutz, M. W., 795 expressed in X laevis oocytes, effects of Saito, K, see Yanai, S., i267 Schwartz, J.-C., see Ligneau, X., 452 alcohols and anesthetics on, 898 Sakai, T., see Satoh, M., 574 SDZ WAG-994, cardiac effects, in guinea Serotonin4 receptors Sakamoto, T., see Lee, J. Y., 1713 pig, 1371 antagonists Sala, A., see Wheelan, P., 1514 Sehic, E., Ruan, Y. and Malik, K U.: At- in adult hippocampal neurons, 255 Salaices, M., see Casade, M. A., 1638 tenuation by aj3-methylenade- binding to sigma-i sites in guinea pig Sabicybate, inhibition of hPGHS-i and -2 nosine-5’-triphosphate of periar- brain, 484 by, 927 terial nerve stimulation-induced in bovine mesenteric lymphatics, 379 Saline, drug discrimination assessment of renal vasoconstriction is not due effects in 5-HIP-induced diarrhea in opioids in humans, 48 to desensitization of purinergic mice, 741 Sanders-Bush, E., see Grotewiel, M. S., receptors, 983 Serotonin2 receptors, in bovine mesenteric 1122 Seidler, F. J., see Wagner, J. P., 472 lymphatics, 379 Sandimmune, see Cycbosporine A Seizure susceptibility, during estrus cycle, Serotoninc receptors, regulation of Sano, I., see Satoh, M., 574 164 ACTH secretion by, 1647 Sano, I., see Yamamoto, 0., 1471 l-Sebectin, monocbonal antibody HUDREG- Serotonin receptors, subtype roles in DOM Sapru, M. K, Diamond, I. and Gordon, A. 200 against, cardioprotective ef- neuroendocrine effects, in rats, S.: Adenosine receptors mediate fects in feline myocardial reperfu- 143 cellular adaptation to ethanol in sion injury, 134 Sevilla, C., see Defacque, H., i93 NG1O8-i5 cells, 542 Sebvaag, S., see Collins, A. C., 125 Sevilla, M. A., see Casado, M. A., 1638 Sarafotoxin S6c, effects on thermal noci- Sematilide, rate-dependent APD probon- Sexe, R. B., see James-Kracke, M. R., 824 ception, 156 gation by, in guinea pig ventricu- Shapiro, B. H., see Pampori, N. A., 1067 Sarna, S. K, see Orihata, M., 660 bar myocytes, 302 Shebuski, R. J., see Erickson, L. A., 415 Satoh, M., Sakai, T., Sano, I., Fujikura, K, Sensitivity, see also Supersensitivity Shefner, S. A., see Osmanovic, S. S., 334 Koyama, H., Ohshima, K, Itoh, Z. to brain nicotinic receptors, effects of Shen, D. D., see Thummel, K E., 549, 557 and Omura, S.: EM574, an eryth- chronic nicotine and Shetty, S. S. and DelGrande, D.: Inhibi- romycin derivative, is a potent mecamylamine infusion on, 125 tion by nickel of endothelin-i-in- rnotilin receptor agonist in hu- to convulsants, during estrus cycle, 164 duced tension and associated man gastric antrum, 574 differential, cardiovascular, to cocaine, 45Ca movements in rabbit aorta, Saussy, D. L., Jr., see Goetz, A. S., 1228 causes of, 1103 1223 Sauzieres, J., see Cussac, C., 1353 naloxone, of opiate withdrawal indices, Shi, A.-G. and Deth, R. C.: Precoupling of Sawanobori, T., Adaniya, H., Namiki, T. i39i alpha-2B adrenergic receptors and Hiraoka, M.: Rate-dependent to nicotine, effects of chronic nicotine and G-proteins in transfected effects of sematilide en action po- and mecamylamine infusion on, PC-12 membranes: Influence of tential duration in isolated i25 pertussis toxin and a lysine-di- guinea pig ventricular rnyocytes, Sensorimotor gating, of startle response, rected cross-linker, 1520 302 cbozapine effects on PCP-induced Shiba, Y., see Yamamoto, 0., i47i Saydoff, J. A., see Maciag, C. M., 891 deficits in, 787 Shibamoto, T., Chakder, S. and Rattan, S.: SB 209670 Sepp#{225}l#{225},T., see Id#{226}npA#{226}n-Heikkil#{226},J. J., Role ofhypogastric nerve activity effects on acute renal failure in anesthe- 1306 in opossum internal anal sphinc- tized dogs, 769 Serotonin tar function: Influence of surgical effects on ET-i binding to human ETA inhibitory effects on PHDA neurons, and chemical denervation, 277 and ETB receptors, 755 GABA receptor mediation of, Shibata, Y., see Ueda, F., 397 pharmacological characterization of, 1000 Shimamura, H., Suzuki, H., Hanano, M., 762 interaction with dopamine, electro- Suzuki, A., Tagaya, 0., Horie, T. SCH 23390, behavioral effects, 638 physiological study of, in rat yen- and Sugiyama, Y.: Multiple eye- Schaub, C. L., see Mittelman, G., 638 tral tegmental area, 83 tame for the biliary excretion of Schedule-induced polydipsia, dopamine ef- inward current in nodose ganglion neu- organic anions in rats: Liquiriti- fects on, 638 rons induced by, cocaine effects genin conjugates as model corn- Scheurer, U., Drack E. and Halter, F.: on, in, 262 pounds, 370 Substance P activates rat cobonic mediation by 5-HT1A receptors, effects Shimoyama, N., see Yamamoto, T., 156 motility via excitatory and inhib- of prenatal cocaine exposure en, Shin, J.-G., see Koyama, E., 860 itory neural pathways and direct in male vs female rat progeny, Shin, S.-G., see Koyama, E., 860 action on muscles, 7 1453 Shin, Y. W., see Hong, K W., 1591 Schmitz, W., see Neumann, J., 535 neonatal hypoxia-associated increase in, Shinmck-Gallagher, P., see Yu, B., 590 Schneider, C. R., see Simmons, M. A., 581 1299 Shoyama, Y., see Sugiura, M., 703 Schoepp, D. D., see Watts, S. W., 832 SerotoninlA receptors Shryock, J. C., see Bebardinelli, L., 1371 Sch#{246}lkens, B. A., see Wiemer, G., i6ii agonists Shuck, M. E., see McCall, R. B., 875 1994 Index 1741

Shukla, S. D., see James-Kracke, M. R., Smooth muscle cells SR 47436, N-glucuronidation of, by rat, 824 circular cecum, muscariic receptor sub- monkey and human hepatic mi- Shukrula, S., see Voss, H.-P., 386 types in, in rabbit, 149 crosomal fractions, 91 Siggins, G. R., see Nie, Z., 1566 coronary artery, potassium currents in, Staley, J. K, Hearn, W. L., Ruttenber, A. Sigma receptors modulation by NS-004, in canine, J., Wetli, C. V. and Mash, D. C.: antagonism ofopioid analgesia by, 1583 362 High affinity cocaine recognition regulation of dopamine release from rat portal vein, inhibitory effects of isoflu- sites on the dopamine transporter striatum by, 212 rane on Ca channels in, in are elevated in fatal cocaine ever- Sigma-i receptors guinea pig, 1159 dose victims, 1678 antiopioid system, 1583 vascular Stanley, P. L., see Tramposch, K M., 852 binding sites, RS-23597-i90 binding to, inhibition by U-86983, in rat, 415 Stark, H., see Ligneau, X., 452 in guinea pig brain, 484 mediation by AT1 receptors, in rat, Startle response, sensorimotor gating of, Silbernagl, S., see Gekle, M., 1 429 cbozapine effects on PCP-induced Silver, P. J., Dundore, R. L., Bode, D. C., Sodium channels deficits in, 787 de Garavilla, L., Buchholz, R. A., cardiac, cocaethylene blockade, 319 Stereoselectivity, ofP45O 2C8 and 2C9 ep- van Aller, G., Hamel, L. T., Ba- effects in release enhancement by li- oxidation of arachidonic acid, con, E., Singh, B., Lesher, G. Y., 1427 nopirdine, in rat cerebral cortical Hiasta, D. and Pagani, E. D.: Cy- Steroids, modulation of NMDA receptor- slices, 891 clic GMP potentiatien by WIN induced increases in intracellular Sohii, D.-R., see Koyama, E., 860 58237, a novel cyclic nucleotide Ca by, 677 Solid meals, gastric emptying of, regula- phosphodiesterase inhibitor, Stewart, R. B., Lemaire, G. A., Roache, J. tion by nitric oxide synthase, 660 1143 D. and Meisch, R. A.: Establish- Somatodendritic autoreceptors, systemic Simmons, C. A., see Erickson, L. A., 415 ing benzediazepines as oral rein- DA receptor blockade of, regula- Simmons, M. A., Schneider, C. R. and forcers: Midazolam and diazepam tion ofDA neurons by, 1181 Krause, J. E.: Regulation of the self-administration in rhesus Somegyi, A., see Cleary, J., 1528 responses to gonadotropin-releas- monkeys, 200 Sonsalla, P. K, see Delbe Donne, K T., ing hormone, muscarine and sub- Stinus, L., see Schulteis, G., i39i 1320 stance P in sympathetic neurons Stomach, see under Gastric d-Sotalol, effects on ischemic and reperfu- by changes in cellular constitu- Storer, B. L., see Sung, C.-P., 429 sion arrhythmias, 184 ents and intracellular application Straub, J. A., see Doctrow, S. R., 229 dl-Sotalob, effects on ischemic and reperfu- of peptide fragments of the sub- Stress, inhibitory effects en PHDA neu- sion arrhythmias, 184 stance P receptor, 581 rons, GABA receptor mediation SPC-i00097, see NSC 639366 SIN-i relaxations, effects of K channel of, 1000 blockers en, in guinea pig tra- Specian, R. D., see Grisham, M. B., 1114 Strichartz, G., see Desai, S., 220 chea, 782 Species orthobogs, bovine and rat vs hu- Strychnine-binding proteins, in intestinal Singh, B., see Silver, P. J., 1143 man and porcine alpha-2A adre- cells, 1074 Singhal, P. C., see Mattana, J., 311 noceptors, pharmacological char- Substance P Skeen, G. A., White, H. S. and Twyman, R. acteristics of, 735 activation of rat cobonic motility by, 7 E.: The dihydropyridine nitren- Spinal cord, neciceptive information trans- N-terminal metabolites, mediation of dipine reduces N-methyl-D-aspar- mission in, effects of ET-A and capsaicin antinociceptive effects tate (NMDA)-evoked currents of ET-B receptors on, 156 by, in adult mouse, 1281 rodent cortical neurons through a Spinal electrical stimulation, pressor re- regulation of M-current in sympathetic direct interaction with the NMDA sponse to, effects of vascular at- neurons by, 581 receptor-associated ion channel, pha-i adrenoceptors on, in pithed vascular contents, effects of chronic nic- 30 rats, 748 otine on, in rats, 1135 Sket, D., see Krisch, I., 343 Spinal muscariic analgesia, mediation by Substituted guanidines, in vitro neuropre- SKF 38393 l-arginine/itric oxide/cyclic GMP tection by, 1080 behavioral effects, 638 cascade, 601 Sugiura, M., Shoyama, Y., Saito, H. and effects on basal ganglia output, in reser- Spinal nicotinic agents, stimulatory path- Abe, K: Crocin (crocetin di-gen- pine and 6-OHDA-treated rats, ways and sites of action of, 1550 tiobiose ester) prevents the inhib- 1434 Spiperone, effects on DOM neuroendo- itory effect of ethanol on long- SKF 82958, behavioral effects, 638 crime effects, in rats, 143 SKF 83566, behavioral effects, 638 term potentiation in the dentate Spiradoline, antineciceptive effects, in SKF 94836, effects on NANC contractions, gyrus in vivo, 703 squirrel monkeys, i501 in guinea pig bronchus, 811 Sugiyama, Y., see Kuwabara, T., 1535; Spiroperidol, DA-binding to, and GM1 ef- SKF 10047, regulation of dopamine re- Shimamura, H., 370 fects on DA supersensitivity, lease from rat striatum by, 2i2 Sullivan, J. P., Decker, M. W., Brioni, J. ii93 Slikker, W., Jr., see Broening, H. W., 285 D., Donnelly-Roberts, D., Ander- Splenic natural killer cells, effects of acute Sbotkin, T. A., see Wagner, J. P., 472 son, D. J., Bannon, A. W., Kang, ethanol on, in mouse, 722 Sluka, K A., Willis, W. D. and Westlund, C.-H., Adams, P., Piattoni- K N.: Inflammation-induced re- Spontaneous hypertension, effects of eth- Kaplan, M., Buckley, M. J., Go- anob on cardiac output in, in rats, lease of excitatory amino acids is palakrishnan, M., Williams, M. prevented by spinal administra- ii5O and Arneric S. P.: (±)-Epibatidine tion of a GABAA and not by a Spuhler-Phillips, K, see Lee, Y.-H., 1291 elicits a diversity of in vitro and GABAB ptor antagonist in SR 48527, effects on intestinal neuroten- in vivo effects mediated by nice- rats, 76 sin binding and contractile re- tinic acetylcholine receptors, 624 Smad.ja, C., see Noble, F., 1127 spouses in guinea pig, 267 Sullivan, M.H.F., see Knock, G. A., 1007 Smart, J. L., see Dectrow, S. R., 229 SR 48692, effects on intestinal neuroten- Sumners, C., see Chandler, L. J., 67 Smith, G.C.S., Coleman, R. A. and sin binding and contractile re- Sung, C.-P., Arleth, A. J., Storer, B. L. and McGrath, J. C.: Characterization sponses in guinea pig, 267 Ohistein, E. H.: Angiotensin type of dilator prostanoid receptors in SR 49711, effects on intestinal neuroten- 1 receptors mediate smooth mus- the fetal rabbit ductus arteriosus, sin binding and contractile re- cle proliferation and endothelin 390 sponses in guinea pig, 267 biosynthesis in rat vascular Smith, M. W., see McCall, R. B., 875 SR 33557, effects on voltage-activated smooth muscle, 429 Smith, W. L., see Laneuville, 0., 927 Ca channels, 1348 Sufiol, C., see Pom#{233}s,A., 1616 1742 Index Vol. 271

Superoxide anion, PDE N inhibitor effects THC, see 9-Tetrahydrocannabinol Topical ocular insulin, absorption-enhanc- on, 1167 Thermal nociceptive test, effects of ET-A ing effects of alkylgbycesides on, Superoxide dismutase, lecithinized, phar- and ET-B receptors on, 156 in rat, 1274 macobogic potency, 1672 Thomas, E. A. and Ehlert, F. J.: Pertussis Terres, G. E., Hebt, I. L. and Andrade, R.: Supersensitivity toxin blocks M2 muscarinic recep- Antagonists of 5-HT4 receptor- behavioral, haloperidol-induced, effects tor-mediated effects on contrac- mediated responses in adult hip- ofGM1 on, in rats, 1193 tion and cyclic AMP in the guinea pocampal neurons, 255 dopamine pig ileum, but not M3-mediated Torsemide, effects on distal convoluted tu- GM1 effects on, in rats, 1193 bule cells, 403 contractions and phosphoinosit- G-protein effects on, 422 Totzke, M., see Merchant, K M., 460 ide hydrolysis, 1042 Suzuki, A., see Shimamura, H., 370 Toxicity THP-i cells, human monocytic, effects of Suzuki, H., see Kuwabara, T., 1535 DCTH, 515 prostacyclin analogs on, 446 Suzuki, H., see Liu, Y.-W., 567 fluoroquinobone, in vitro, 1544 Three-choice saline-hydromorphone-bu- Suzuki, H., see Shimamura, H., 370 MDMA, age modulation of, 285 Svartengren, J., see Bj#{246}rk,A., 1338 torphanol procedure, for drug dis- METH-induced Svensson, K A., see McCall, R. B., 875 crimination assessment of opioids adenesine protection against, 1320 Swerdlow, N. R., see Bakshi, V. P., 787 in humans, 48 in mice, 1051 Sympathetic nervous system Thromboxane A2 receptors Trachea effects in indomethacin-induced antral cloning from K562 cells, 1034 5-HT2A receptors in, in guinea pig, 832 and corpus lesions, in rats, 695 ifetroban antagonist, inhibition of cre- K channel bbocker effects on NANC M-current in, regulation of, 581 mepher vascular effects by, 730 and NO donor relaxations in, in mediation ofIL-2 effects on antigen-spe- Thummel, K E., Shea, D. D., Podoll, T., guinea pig, 782 cific 1gM PFC responses by, 977 Kunze, K L., Trager, W. F., Bac- Trager, W. F., see Thummel, K E., 549; pressor response to, effects of vascular chi, C. E., Marsh, C. L., McVicar, Thummeb, K E., 557 alpha-i adrenoceptors en, in J. P., Barr, D. M., Perkins, J. D. Tramposch, K M., Chilton, F. H., Stanbey, pithed rats, 748 and Carithers, R. L., Jr.: Use of P. L., Franson, R. C., Havens, M. Sympatheexcitation, central, mediation of midazelam as a human cyte- B., Nettleton, D. 0., Davern, L. differential cardiovascular sensi- chrome P450 3A probe: II. Char- B., Darling, I. M. and Bonney, R. tivity to cocaine by, 1103 acterization of inter- and intrain- J.: Inhibitor of phospholipase A Synaptic transmission, IL-1J3 inhibition of, dividual hepatic CYP3A blocks eicesanoid and platelet ac- in amygdala neurons, 590 variability after liver traneplan- tivating factor biosynthesis and Synaptic vesicles, DA uptake into, inhibi- has topical anti-inflammatory ac- tation, 557 tivity, 852 tion by cocaine congeners, struc- Thummel, K E., Shea, D. D., Podoll, T., Transcellular electrolyte transport, loop ture-activity relationships for, in Kunze, K L., Trager, W. F., Hart- rat brain, 1444 diuretic effects on, in distal con- well, P., Raisys, V. A., Marsh, C. voluted tubule cells, 403 TA 2005, selectivity of, in guinea pig heart, L., McVicar, J. P., Barr, D. M., Transplantation, effects of liposomal 386 Perkins, J. D. and Carithers, R. methylprednisobone on cardiac al- Tachykinin NK1 receptors, mediation of L., Jr.: Use ofmidazolam as a hu- begraft survival in, in rats, 868 6-keto-PGF1a release from canine man cytochrome P450 3A probe: i,2,2-Trifluorocycbobutane, effects on ileum by, 39 I. In vitro-in vivo correlations in 5-HT3 receptors, 898 Tachykiin NK receptors, polycyclic pep- liver transplant patients, 549 m-Trifluoromethybphenylpiperazine, tide antagonist MEN 10,627, Thuong-Guyot, M., Domarle, 0., Pocidalo, 5-HT2A agonist effects, 1122 1489 J.-J. and Hayem, G.: Effects of Troisi, J. R., II, see Evans, S. M., 683 Tachykinins, mediation of 6-keto-PGF1,, fluoroquinelones en cultured ar- Tronquet, C., see Perrier, L., 91 release from canine ileum by, 39 ticular chendrocytes flow cyto- Teal, T. D., see Xu, X., 362 Tagaya, 0., see Shimamura, H., 370 metric analysis of free radical Tsuji, T., see Niiya, K, 14 Takano, S., Gateby, S., Jiang, J. B. and production, 1544 Tumor necrosis factor-a, synthesis in hu- Brem, S.: A diamineanthraqui- Thurau, K, see Beck, F. X., 403 man monecytic THP-i cells, ef- none inhibitor of angiogenesis, Thyroid hormone, effects on beta receptor fects of prostacyclin analogs on, 1027 signaling, in developing rat brain, 446 Takei, Y., see Oshita, M., 20 472 Turnbull, B., see Doctrow, S. R., 229 Tam, S. W., see Maciag, C. M., 891 Thyrotopin-release hormone analog, ef- Twyman, R. E., see Skeen, G. A., 30 Tamoxifen, inhibition of phospholipase C fects on acetylcholine release, in Tyrosine hydroxylase cell number, and by, in GH4C1 cells, 238 rat brain, 884 haloperidob-induced catalepsy, Tandospirone, behavioral effects and Tinker, W. J., see Macjag, C. M., 89i 969 abuse liability in humans, com- Tirilazad mesylate, see U-74006F parison with alprazolam, 683 U-50488H, antinociceptive effects against Tissue factor, synthesis in human mono- Taylor, P., see Khan, I. M., 1550 inflammation, 1306 cytic THP-i cells, effects of pros- Tenma, T., see Yodoya, E., 1509 U-62066, see Spiradoline tacyclin analogs on, 446 Tepoxalin, anti-inflammatory effects and U-69593, antinociceptive effects, in squir- gastrointestinal proffle, 1399 TNP-470, in MCT solution via hepatic ar- reb monkeys, 1501 Tepperman, B. L., Brown, J. F., Korolk- tery, antitumor effects, in rats U-74006F, protective effects against endo- with Walker 256 carcinosarcoma iewicz, R. and Whittle, B.J.R.: Ni- toxin shock and acute liver fail- tric oxide synthase activity, via- in liver, 1267 ure, in rats, 438 bility and cyclic GMP bevels in rat To, Z. P., see Bonhaus, D. W., 484 U-86983, inhibition ofrat vascular smooth colonic epithelial cells: Effect of Tocainide, pharmacodynamics, effects of muscle cells by, 415 endotoxin challenge, 1477 dietary fat en, in rabbit hearts, U-92016A, 5-HT1A agonist properties, 875 Tetragastrin, intestinal permeability, in i76 Uchida, S., see Niiya, K, 14 rats, 1509 Toguchi, H., see Yanai, S., 1267 Uchida, Y., see Lee, J. Y., 1713 9-Tetrahydrocannabinol, cross-tolerance Tolerance, see also Desensitization; Sensi- Ueda, F., Kameda, Y., Yamamoto, 0. and with CP 55,940 and WIN 55,212, tivity Shibata, Y.: Beta-adrenergic rag- 1383 to S-HTIA agonist-induced vagal brady- ulation ofgap-junctional interceb- Tetrazole N-glucuronidation, 91 cardia, 776 bular communication in cultured TFMPP, see m-Trifluoromethylphe- Topical anti-inflammatories, rabbit gastric epithelial cells, 397 nylpiperazine BMS-i8ii62, 852 Uemura, K, see Yodeya, E., 1509 1994 Index 1743

Uhl#{233}n,S., Porter, A. C. and Neubig, R. R.: Mn-DPDP- and Mn-Cl2-induced ende- Wanstall, J. C.: In vitro hypoxia attenu- The novel alpha-2 adrenergic ra- thelium-dependent, in bovine ates vasorelaxation by potassium dieligand [3H]-MK912 is al- mesenteric arteries, 609 channel opening drugs and nitro- pha-2C selective among human modulation by muscarinic receptors, in prusside in isolated pulmonary alpha-2A, alpha-2B and al- guinea pig carotid artery, 1638 arteries from rats, 845 pha-2C adrenoceptors, 1558 prostaglandin receptor, in fetal rabbit Ward, S., see Fan, F., 1383 Ukai, Y., see Itoh, Y., 884 ductus arteriesus, 390 Watanabe, T. and Egawa, M.: Effects of an Ulcers VD3, see ia,25-Dihydroxyvitamin D3 antistroke agent MC1-i86 on ce- indomethacin-induced, sympathetic Ventral tegmental area rebral arachidonate cascade, nerve effects in, in rats, 695 cocaine effects on monoamine interac- 1624 psychological stress, 5-HT3 receptor ef- tiens in, in rats, 1597 Watrous, J. M., see Farina, P. R., 1418 fects in, mouse, 100 serotonin-dopamine interaction in, elec- Watts, S. W., Cox, D. A., Johnson, B. G., Unal, C. B., Owen, M. D. and Millington, trophysiobogicab study in vivo, in Scheepp, D. D. and Cohen, M. L.: rat, 83 W. R.: Beta-endorphin-induced Contractile serotonin-2A receptor Ventricular cells, neonatal, alpha-i adren- cardiorespiratory depression is signal transduction in guinea pig ergic modulation ofb-type calcium inhibited by glycyl-b-glutamine, a trachea: Importance efprotein ki- channels in, in rat, 935 dipeptide derived from beta-en- nase C and extracellular and in- intracellular mechanisms of, 944 dorphin processing, 952 tracellular calcium but not phos- Ventricular excitability, dietary fat effects Undem, B. J., Meeker, S. N. and Chen, J.: phoinesitide hydrolysis, 832 on quiidine effects on, 176 Inhibition of neurally mediated Weight, F. F., see Fan, P., 262 Ventricular function, effects of febedipine nonadrenergic, noncholinergic Weiss, B., see Zhang, 5.-P., 1462 on, in CHF, 1409 contractions of guinea pig bron- Wemlinger, T. A., see Krajnc, D., 1299 Ventricular myecytes chus by isozyme-sebective phes- Wenzel, U., see Ries, M., 1327 chborpromazine inhibition of K chan- phediesterase inhibitors, 811 Werling, L. L., see Gonzalez-Alvear, G. M., nels in, in rat, 632 Uno, S., see Matzno, S., 1666 212 rate-dependent APD prolongation by se- Upper gastrointestinal contractions, Westlind-Danielsson, A., see Wilkinson, phase III, motilin-induced, inhibi- matilide in, in guinea pig, 302 Verma, S., Bhanot, S. and McNeill, J. H.: A., 1314 tien by pentagastrin, in Heiden- Westlund, K N., see Sluka, K A., 76 Antihypertensive effects of met- hain pouch dogs, 1471 Wetli, C. V., see Staley, J. K, 1678 Urinary bladder, drug absorption from, in- formin in fructose-fed hyperinsu- linemic, hypertensive rats, i334 Weyrich, A. S., see Buerke, M., 134 terstitial cystitis effects on, 818 Wharton, J., Knock, G. A., i007 Veyre, A., see Cussac, C., 1353 see Wheelan, P., Sala, A., Fob, G., Nicosia, Vidrio, H.: Potentiation of cardiovascular Vagal-mediated bradycardia, 5-HT age- S., Falck, J. R., Bhatt, R. K and responses to hydralazine by di- Murphy, R. C.: Stereochemical nist-induced, tolerance to, 776 verse hydrazine derivatives, i7i Van de Kar, L. D., see Rittenhouse, P. A., analysis and biological activity of Visentin, S., see Fan, P., 262 i647 3-hydroxy-leukotriene B4: A me- Vizuete, M. L., see Ligneau, X., 452 van Alber, G., see Silver, P. J., 1143 tabebite from ethanol-treated rat Voltage-activated calcium channels, ef- Vargas, H. M., Thou, L. and Gorman, A. J.: hepatocytes, 1514 fects ofSR33557 and SR33805 on, Role of vascular alpha-i adrene- White, H. S., see Skeen, G. A., 30 1348 ceptor subtypes in the pressor re- Whittle, B.J.R., see Tepperman, B. L., Vonderfecht, S. L., see Liu, P., 438 sponse to sympathetic nerve i477 Venvoigtlander, P. F., see McCall, R. B., stimulation in the pithed rat, 748 Wick, M. J., see Law, P. Y., 1686 875 Vascular myocytes, electrophysiebogical Voss, H.-P., Shukrula, S., Wu, T.-S., Don- Wiechen, K, see Neumann, J., 535 and radioligand binding studies Wiemer, G., Fink, E., Linz, W., Hropot, M., nell, D. and Bast, A.: A functional of ebgodipine in, in portal vein, Sch#{246}lkens, B. A. and Wohlfart, P.: beta-2 adrenoceptor-mediated 1209 Furesemide enhances the release chronotropic response in isolated Vascular smooth muscle cells of endotheliab kinins, nitric oxide guinea pig heart tissue: Sebectiv- Ca channels in, inhibitory effects of and prostacyclin, 1611 ity ofthe potent beta-2 adrenocep- isoflurane on, in guinea pig portal tor agonist TA 2005, 386 Wibde, D. W.: Isoflurane reduces Ca vein, 1159 channel current and accelerates inhibition by U-86983, in rat, 415 Wachter, M. P., see Argentieri, D. C., 1399 current decay in guinea pig portal mediation by AT1 receptors, in rat, 429 Wagner, E. J., see Goudreau, J. L., 1000 vein smooth muscle cells, 1159 potassium currents in, modulation by Wagner, J. P., Seidler, F. J., Lappi, S. E., Wiley, J. W., see Gelperin, D., 507 NS-004, in canine, 362 McCook, E. C. and Sbotkin, T. A.: Wilkins, J., see O’Donnell, J. M., 246 Vasoactive intestinal peptide, effects on Role of thyroid status in the on- Wilkinson, A., Courtney, M., Westlind- substance P activation of cobenic togeny of adrenergic cell signal- Danielsson, A., Hallnemo, G. and motility, in rats, 7 ing in rat brain: Beta receptors, Akerman, KE.O.: Alaproclate Vasoconstriction adenybate cyclase, ornithine do- acts as a potent, reversible and chronic nicotine, in rats, 1135 carboxylase and c-los protoonce- noncompetitive antagonist of the CsA, mediation by cremophor, 730 gene expression, 472 NMDA receptor coupled ion flew, ET, inhibition by nickel, in rabbit aorta, Walker 256 carcinosarcoma, in liver, anti- 1314 i223 tumor effects of MCT solution of Williams, D. J., see Erickson, L. A., 415 levcromakalim effects on, in rat pulme- TNP-470 via hepatic artery on, in Williams, J. K, Kim, Y. D., Adams, M. R., nary artery, 326 rats with, 1267 Chen, M.-F., Myers, A. K and renal nerve stimulation-induced, Walker, E. A., Makhay, M. M., House, J. Ramwell, P. W.: Effects of estre- a,mATP effects on, 983 D. and Young, A. M.: In vivo ap- gen on cardiovascular responses Vasodilation parent pA2 analysis for naltrex- of premenopausal monkeys, 671 adenosine receptor agonist, K.. chan- one antagonism of discriminative Williams, M., see Sullivan, J. P., 624 nel blockade effects on, in core- stimulus and analgesic effects of Willis, W. D., see Sluka, K A., 76 nary artery, 14 opiate agonists in rats, 959 Wilson, G. J., see Erickson, L. A., 415 chronic nicotine, in rats, ii35 Walters, J. R., see Huang, K-X., i434 WIN 58237, cGMP potentiation by, ii43 ebselen, in hepatic vasculature, 20 Wan, W., see Zalcman, S., 977 WIN 55212, cross-tolerance with i9-THC effects of in vitro hypoxia on, in rat pul- Wang, H.-Y., see Butkerait, P., 422 and CP 55,940, 1383 menary arteries, 845 Wang, J., see Xu, X., 362 Winter, J. N., see Dordal, M. S., 1286 furosemide, 1611 Wang, R.-X, see Pillion, D. J., 1274 Wise, R. A., see Bauce, P., 294 1744 Index Vol. 271

Wishka, D. G., see Erickson, L. A., 415 in Heidenhain pouch hyperpolarization in the amyg- Withdrawal, opiate, naloxone-precipi- dogs, i47i dala neurons, 590 tated, multiple indices of, 1391 Yamamoto, S., see Liu, Y.-W., 567 Yukhananov, R. Yu. and Larson, A. A.: Wohlfart, P., see Wiemer, G., i6ii Yamamoto, T., Shimoyama, N., Asano, H. Involvement of NMDA receptors Wolcott, R. M., see Wu, W.-J., 722 and Mizuguchi, T.: Analysis of in naloxone-induced contractions Wolcott, T. C., see Kirk, C. J., 1080 the role ofendothelin-A and ende- of the isolated guinea pig ileum Wong, E.H.F., see Bonhaus, D. W., 484 thelin-B receptors on nociceptive after preincubatien with mor- Woods, J. H., see Burke, T. F., 715 information transmission in the phine, 1365 Woods, J. H., see Emmerson, P. J., 1630 spinal cord with FR139317, an J. H., see Gerak, L. R., 993 Woods, endothelin-A receptor antagonist, Zaczek, R., see Maciag, C. M., 891 Woskowska, Z., see Hryhorenko, L. M., 918 with Sarafotoxin S6c, an endothe- Zalcman, S., Green-Johnson, J. M., Mur- WRK1 cells, nordidemnin effects on, 107 lin-B receptor agonist, 156 ray, L., Wan, W., Nance, D. M. Wu, H.-L., see Nambi, P., 755 Yamanouchi, K, see Matzno, S., 1666 and Greenberg, A. H.: Interbeu- Wu, T.-S., see Voss, H.-P., 386 Yamazaki, A., see Itoh, Y., 884 kin-2-induced enhancement of an Wu, W.-J., Wolcott, R. M. and Pruett, S. Yanai, S., Okada, H., Misaki, M., Saito, K, antigen-specific 1gM plaque- B.: Ethanol decreases the number Kuge, Y., Ogawa, Y. and Toguchi, forming cell response is mediated and activity of splenic natural H.: Antitumor effect efa medium- by the sympathetic nervous eye- killer cells in a mouse model for chain triglyceride solution of the tern, 977 binge drinking, 722 angiegenesis inhibitor of Zaprinast, effects en NANC contractions, Xenopus laevis oocytes, 5-HT3 receptors TNP-470 (AGM-i470) when ad- in guinea pig bronchus, 811 expressed in, effects of alcohols ministered via the hepatic artery Zardaverine, suppression of superoxide and anesthetics on, 898 to rats bearing Walker 256 carci- anion generation by, 1167 Xu,X.,Tsai,T.D.,Wang,J.,Lee,E.W. nosarcoma in the liver, 1267 Zeitung, K D., see Bonhaus, D. W., 484 and Lee, K S.: Modulation of Yang, X. and Buccafusco, J. J.: Effect of Zhang, F. and Morice, A. H.: Effect of levcrornakalim on hypoxia-, KC1- three types of K currents in ca- chronic central treatment with and prostaglandin F2-induced nine coronary artery smooth mus- the acetylcholine analog methyl- contractions in isolated rat pul- cle cells by NS-004, or i-(2’-hy- carbamylcholine on cortical nice- monary artery, 326 droxy-5’-chborophenyl)-S- timc receptors: correlation be- Zhang, 5.-P., Thou, L.-W. and Weiss, B.: trifluoromethyb-2(3H) tween receptor changes and Oligodeoxynucleotide antisense benzimidazolone, 362 behavioral function, 651 to the D1 dopamine receptor Xu, Y.-Q., Crumb, W. J., Jr. and Clarkson, Yodoya, E., Uemura, K, Tenma, T., Fu- mRNA inhibits D1 dopamine re- C. W.: Cocaethybene, a metabolite jita, T., Murakami, M., ofcocaine and ethanol, is a potent ceptor-mediated behaviors in nor- Yamamoto, A. and Muranishi, S.: rnal mice and in mice lesioned blocker of cardiac sodium chan- Enhanced permeability of tetra- nebs, 319 with 6-hydroxydopamine, 1462 gastrmn across the rat intestinal Zheng, J., see Hexu.m, T. D., 61 Yaksh, T. L., see Khan, I. M., 1550 membrane and its reduced degra- Thou, L., see Vargas, H. M., 748 Yamaguchi, I., see Kuratani, K, 695 dation by acylation with various Thou, L.-W., see Zhang, 5.-P., 1462 Yamaguchi, I., see Nomura, K., 100 fatty acids, i509 Zhu, J., see Hexum, T. D., 61 Yamaguchi, 5.-I., see Donevan, S. D., 25 Yeo, S.-E., see Hong, K W., 1591 Zimmerman, T. E., see Grisham, M. B., Yamamoto, A., see Yodoya, E., 1509 Yoshimeto, T., see Liu, Y.-W., 567 1114 Yamamoto, 0., see Ueda, F., 397 Yoshino, T., see Nomura, K, 100 Zimmermann, N., see Neumann, J., 535 Yamameto, 0., Matsunaga, Y., Shiba, Y., Young, A. M., see Walker, E. A., 959 Zinc, effects on ethanol inhibition of Haga, N., Sano, I. and Itoh, Z.: Yu, B. and Shinnick-Gallagher, P.: Inter- NMDA-stimulated NO synthase Inhibition of motilin-induced beukin-il3 inhibits synaptic trans- in cortical neurons, 67 phase III contractions by penta- mission and induces membrane Zong, X. G., see Mehrke, G., 1483 STATEMENT OF OWNERSHIP MANAGEMENT AND CIRCULATION (Required by 39 U.S.C. 3685)

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Endothelin Receptor Agonists and Antagonists

Endothelin- I , human, porcine Endothelin-2, human Endogenous neuropeptide found in endothelial cells; Endogenous neuropeptide found in endothelial cells; ET- I has greatest affinity toward ETA receptors ET-2 displays similar selectivity for ETA and ETB receptors CatNo. E-134 CatNo. E-135

IRL- 1620 BQ-123 Selective B endothelin receptor agonist Selective ETA endothelin receptor antagonist Cat No. E-137 Cot No. B-ISO

Sarafotoxin 6c, (Lys4]- Endothelin-3, human, rat Selective B endothelin receptor agonist Preferred endogenous agonist for the putative ETc endothelin receptor ‘5 Cot No. S-1S7 Cat No. E-136 BQ-3020 Selective ETB endothelin receptor agonist BQ-610 Cat. No. E-139 A endothelin receptor antagonist CatNo. 8-151 RBI#{174} RESEARCH BIOCHEMICALS INTERNATIONAL One Strathmore Road, Natick, MA 01 760-2447 USA

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Cyclic ADP Ribose Cyclic ADPR

NH2

HOj Metabolite of nicotinamide adenine dinucleotide HO H (NAD); potent intracellular 0 Ca2 releaser 0=P- I l 0 0 OH OH

Cat. No. C-201

cx-Cobrotoxin Sepiapterin Selectively blocks nicotinic receptors; isolated from the venom of Intracellularly converts to tetrahydrobiopterin, which the snake Naja Naja Kaouthia leads to the stimulation of nitric oxide Cat. No. C-206 Cat. No. S-154

3-Morpholinosydnonimine hydrochloride Tamoxifen, 4-hydroxy- (E)- Sin-I Metabolite of Tamoxifen; estrogen receptor antagonist Nitric oxide source Cat. No. T-155 Cat. No. M- 184 Tamoxifen, 4-hydroxy- (Z)- Rapamycin Less potent isomer; weak anti-estrogen A microlide immunosuppressant; binds to the FK506 binding Cat. No. T-156 protein (FKBP) through a FK506-calcineunn independent mechanism Cat. No. R-117 Tityustoxin-Ka Potently and selectively blocks the voltage-gated noninactivating (delayed-rectifier) K channel; polypeptide isolated from the Sarafotoxin 6c venom of the Brazilian scorpion Tityus serrulatus Selective ETB endothelin receptor agonist Cat. No. T.154 Cat. No. S-157

Visit RBI at the Society for Neuroscience Meeting, November I 3-I 8 in Miami at Booth No. 830. RBI#{174}Fax or write for our I 995 Catalog/Handbook, describing over I 200 pharmacologically active compounds. RESEARCH BIOCHEMICALS INTERNATIONAL One Strathmore Road, Natick, MA 01 760-2447 USA 508-651 -81 51 #{149}800-736-3690 #{149}Fax 508-655-1 359 #{149}800-736-2480

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