The Editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following colleagues who acted as Guest Editors for Specific Fields in 1991. Martin W. Adler Gary L. Henderson Elaine Sanders-Bush Edson X. Albuquerque Barry Hotter Lewis S. Seiden Joan Heller Brown Robert M. Joy Jerry Sepinwall Thomas F. Burks Suzanne G. Laychock Theodore A. Slotkin Peter Cervoni Benedict R. Lucchesi Larry Stein Marlene L. Cohen Michael I. Luster Boris Tabakoff Richard A. Cohen Harry S. Margolius Robert Taber Charles A. Craig John C. McGiff A. E. Takemon Linda A. Dykstra Kenneth P. Minneman R. Clinton Webb Harold Feinberg Alan S. Nies Thomas C. Westfall Ray W. Fuller Michael Peach Grant R. Wilkinson James W. Gibb Arthur Raines Raymond Winquist John W. Hadden Mark J. Reasor Paul H. Wooley Additionally, sincere thanks are due to 567 of our colleagues not on the Editorial Advisory Board who reviewed articles for the Journal in 1 991 . Their contributions are acknowledged individually in the Annual Report of The Journal to The Board of Publications Trustees of the American Society for Pharmacology and Experimental Therapeutics. INDEX Volume 261 , April-June, 1992 Abe, Y., Kitada, Y. and Narimatsu, A.: Ben- Adenylyl cyclase Aldosterone, antihypertensive effects of Y- eficial effect of MCI-154, a cardi- brown fat, perinatal changes, beta adre- 27152 (rats, dogs), 730 otonic agent, on ischemic contractile noceptors (rats), 633 Alfentanil failure and myocardial acidosis of dog coupling of beta-i and -3 adrenergic re- -reinforced responding, effects of bupren- hearts: Comparison with dobuta- ceptors, agonist exposure (rats), 638 orphine (monkeys), 311 mine, milrinone and pimobendan, Adipocytes, beta-i and -3 adrenergic recep- use of 2-hydroxypropyl-3-cyclodextrin, 1087 tors, adenylyl cyclase, agonist expo- intrathecal drug vehicle (rats), 592 Abernethy, D.R., see Andrawis, N. S., 879 sure (rats), 638 Allan, A. M., Baier, L. D. and Zhang, X.: Acetaminophen, sulfate and 3’-phosphoad- Adipose tissue, brown fat adenylyl cyclase, Effects of lorazepam tolerance and enosine 5 ‘ -phosphosulfate, homeo- perinatal changes, beta adrenocep- withdrawal on GABAA receptor-op- stasis (rats), 1015 tom (rats), 633 erated chloride channels, 395 Acetaminophen glucuronide, impaired bili- Adler-Graschinsky, E., see Elgoyhen, A. B., Allen, G. T., see Harris, D. N., 131 ary excretion, phenobarbital, liver 534 Allen, M. S., see Takada, K., 138 (rats), 1022 Adrenoceptors Allergic reaction, control of contractile re- Acetylcholine alpha, subtypes involved in emetic action sponse, histamine N-methyltransfer- cholecystokinin receptors, mediation of (dogs), 746 ase, trachea (guinea pigs), 1268 contraction, ileum longitudinal mus- alpha-i, block of angiotensin Il-mediated Alm, P., see Holmquist, F., 795 cle myenteric plexus (guinea pigs), vasoconstriction (humans), 879 Alonso, M. J., Salaices, M., Sanchez-Ferrer, 1056 atpha-2 C. F. and Mann, J.: Predominant role neurokinin receptors and mucosal ion agonists, opposite rank order of potency for nitric oxide in the relaxation in- transport, jejunum (pigs), 1213 (rats), 1080 duced by acetylcholine in cat cerebral NMDA-increased release from striatum agonists and antagonists, intrathecal arteries, 12 and cortex, augmentation by choline administration (rats), 764 Alper, R. H., see Itoh, H., 225 (rats), 1122 central actions of nitroglycerin, cortex Alzheimer’s disease, neocortical pyramidal relaxation of cerebral arteries, role for membranes (rats), 1187 neurones, 5-HT1A receptors, intras- nitric oxide (cats), 12 clonidine effects, chronic congestive triatal volkensin (rats), 1273 releasing properties, benzimidazolone de- heart failure (rats), 1129 Amenta, F., see Ricci, A., 830 rivatives, ileum (guinea pigs), 412 kidney (rats), 1050 Amiloride, lithium and, collecting tubule 1-a-Acetylmethadol, differential influence beta transport enzymes (rats), 701 of N-dealkylation, stimulus proper- adenylyl cyclase, adipocytes (rats), 638 -y-Aminobutryic acid, chronic benzodiaze- ties, opioid agonists (monkeys), 278 inhibition of positive inotropic re- pine administration, PK11195, at- a1-Acid glycoprotein, stereoselective phar- sponses, catecholamines in papillary tenuation of chronic effects of bra- macokinetics, propranolol, age and zepam (mice), 285 muscle (rabbits), 1160 gender influences (humans), 1181 ‘y-Aminobutyric acid, -stimulated chloride perinatal changes, brown fat adenylyl Acidosis, myocardial, ischemic contractile flux, benzodiazepine receptor occu- cyclase (rats), 633 failure, beneficial effect of MCI-154 pancy (rats), 1106 propranolol, stereoselective pharmaco- (dogs), 1087 p-Aminohippurate, kidney multidrug trans. kinetics (humans), 1181 Acquired immunodeficiency syndrome, porter, cyclosporine effect, colchicine regulation by thyroid hormone, heart transport of recombinant CD4, secretion (rats), 50 and kidney (rats), 951 through the blood.brain barrier Ammon, H. P. T., see Safayhi, H., 1143 prejunctional, chronic epinephrine treat- (rats), 1175 Amphetamine ment, sympathetic neurotransmis- ACTH, cholecystokinin-A and -B receptor acute administration, regulation of dopa- sion in mesentery (rats), 924 antagonists, fl-endorphin secretion mine synthesis (rats), 567 Aging (rats), 454 locomotor activity, acute sensitivity, Adenosine diphosphate, purinergic receptor gender and, stereoselective pharmacoki- FAST and SLOW mice, 525 netics, propranolol (humans), 1181 expression, K562 cells, 580 region-specific regulation, clozapine 1, ex- Adenosine triphosphatase increased sensitivity to anesthetic effect, trastriatal dopamine D2 receptors collecting tubule transport enzymes, lith- phenobarbital, BN/BiRij rats, 81 (rats), 1282 ium and amiloride (rats), 701 toluene and trichloroethylene metabo- sensitization of locus ceruleus neurons, inhibitor of H,K-ATPase, AHR-9294, lism, liver (rats), 869 during withdrawal (rats), 476 gastric HC1 secretion (rats, dogs), 737 Agonist, -related differences in relationship, -stimulated motor activity, block by quin- Adenosine triphosphate cAMP content and protein kinase ac- pirole microinjection, AlO dopamine -sensitive K channels, inhibition by gli- tivity, trachealis (dogs), 1260 region (rats), 811 benclamide, cardiac muscle (guinea AHR-9294, inhibitor of H,K-ATPase, gas- Amphetamines pigs), 540 tric HC1 secretion (rats, dogs), 737 discriminative stimulus effects of mor- toxicity of 1-methyl-4-phenyl-1,2,3,6-tet- Airway phine, agonist and antagonist effects, rahydropyridine, primary cultures, inhibitory effects, cromakalim and BRL mu opioids (rats), 246 astrocytes (mice), 44 38227 (guinea pigs, humans), 429 lasting effects of 3,4-methylenedioxyme- Adenylate cyclase relaxant properties of S-nitrosothiols thamphetamine, central serotonergic beta adrenergic receptors and, regulation (guinea pigs), 154 neurons, nonhuman primates, 616 of ontogeny, thyroid hormone (rats), Albuquerque, E. X., see Pereira, E. F. R., Amygdala, role of different brain structures, 951 331 morphine withdrawal syndrome highly potent beta-2 sympathomimetics, Alcohol, -preferring C57BL/6 mice, hypo- (rats), 669 conversion to partial agonists, tra- thalamic 9-endorphin system, sensi- Analgesia chea relaxants (guinea pigs), 258 tivity to ethanol, 788 /3-endorphin and morphine, release of 1292 1992 Index 1293 met-enkephalin, forebrain (rats), synthase activity, calmodulin inhibi- smoking: Effect of varying 9-tet- 1028 tors (rats), 553 rahydrocannabinol content and inhibition ofenkephalin-metabolizing en- rings, relaxant effects, 9-carbolines (rats), number ofpuffs, 114 zymes, RB 101 (mice, rats), 181 534 pharmacodynamics and pharmacoki- Aracava, Y., see Pereira, E. F. R., 331 Baclofen, modeling ofeffect site equilibrium netics, morphine, spontaneously hy- Arch, J. R. S., see Taylor, S. G., 429 kinetics, pharmacodynamics, quan- pertensive and normotensive rats, Argatroban, comparative antithrombotic ef- titative EEG effect measures (rats), 290 fects, femoral vein platelet-rich mu- 88 pharmacologic activity of CI-977 (mon- ral thrombosis model (hamster), 895 Baggs, R. B., see Finkelstein, M. B., 1248 keys), 1044 Arginine, N-substituted compounds, blood Baier, L. D., see Allan, A. M., 395 Anazodo, M, I., see Safayhi, H., 1143 pressure (rats), 875 Bailey, J., see Reenstra, W. W., 737 Baroreflex, changes produced by serotoner- Anders, M. W., see Finkelstein, M. B., 1248 Armando, I., see Kvetnansky, R., 899 gic or catecholaminergic lesions, nu- Andersson, K.-E., see Holmquist, F., 795 Aronstam, R. S., see Pereira, E. F. R., 331 cleus tractus solitarius (rats), 225 Andrawis, N. S., Craft, N. and Abernethy, Artery Barreiro, E. J., see Pereira, E. F. R., 331 D. R.: Calcium antagonists block an- cerebral Barrett, J. B., see Takada, K., 138 giotensin Il-mediated vasoconstric- relaxation induced by acetylcholme, Bay K 8644, dual effects of endothelins, tion in humans: Comparison with role for nitric oxide (cats), 12 field-stimulated ileum (guinea pigs), their effect on phenylephrine-in- susceptibility of vasodilator nerve, cab- 1253 duced vasoconstriction, 879 cium antagonists (dogs), 234 Beaune, P. H., see Flinois, J.-P., 381 Anesthetics coronary Behavior alteration of general potency, agonists activation of relaxation cascade, brief buprenorphine’s effects on self-adminis- and antagonists, polyamine binding electrical pulses (cattle), 209 tration, smoked cocaine base, PCP/ site of NMDA receptor (mice), 304 antithrombotic activity, D-methyl- ethanol/saccharin (monkeys), 26 increased sensitivity to phenobarbital,