The john curtin school of medical research Annual Review 2014
ANU College of Medicine, Biology & Environment contents
Annual Review 2014 The John Curtin School of Medical Research
From the Director 3 Staff and Student Lists 45
Department of Genome Biology 46 Organisation Chart 4 Department of Immunology 48 Eccles Institute of Neuroscience 50 Committees 5 Department of Molecular Bioscience 52 Department of Pathogens and Immunity 54 Community 7 Australian Phenomics Facility 55 Launch of the National Centre for Indigenous Genomics 8 School Administration 56 The Judith Whitworth Fellowship 9 School Services 56 The 2nd Annual Dinner of The John Curtin Medical The ACRF Biomolecular Resource Facility 57 Research Foundation 10 Genome Discovery Unit Launch of the Centre for Personalised Immunology 11 Imaging and Cytometry Facility 57 Welcome to the Centenary Chair in Cancer Research 12 Students 58 The Sarah Grace Sarcoma Foundation 13 The John James Foundation Tony Ayers Prize 14 Publications, Presentations and Open Day 15 Community Outreach 61
The JCSMR Director’s Christmas Morning Tea 16 Publications 62 Our Community 17 Staff Presentations 68 Student Presentations 73 Staff and Student Achievements 21 Community Outreach 77 Graduates 22 Support to JCSMR 85 Prizes and Awards 23 Grants 86 Financial Overview 90 Visitors and Collaborators 29 Donors 91 Report from The John Curtin Medical Research Foundation 92 Visitors 30 Sponsors 93 Collaborators 32
Annual Review 2014 1 2 The John Curtin School of Medical Research From the director
It is our great pleasure to share the achievements and activities respectful genetic and genomic research that will benefit of the John curtin school of Medical Research for 2014. A Indigenous Australians, and in April, in conjunction with World companion volume, Research Highlights, describing some of our Day of Immunology, we launched the Centre for Personalized current research projects, will be posted in December 2015. Immunology, which aims to help people with immune diseases by discovering individual genetic variations with the ultimate goal I joined the School as Director in October 2014, and I would like of targeting treatments more effectively. to thank my predecessor, Professor Chris Parish, for stepping into the role of Director in April 2013, and for his leadership of the the JcsMR Gender equity committee successfully brought School. In 2014, Chris was honoured with the title ACT Citizen of about the establishment and award of the inaugural Judith the Year, and received The Chancellor’s Award for Distinguished Whitworth Fellowship in 2014. this Fellowship, named in honour Contribution to the University. He is to be congratulated for these of previous JcsMR Director Professor Judith Whitworth, and stellar achievements, and thanked by all of us for his enduring supported by JcsMR and the John curtin Medical Research dedication to JCSMR. Foundation has been established to support the return to work of a young scientist who has experienced a break in their Many other JCSMR staff and students received honours and research career due to maternity or parental leave. We are very awards during 2014, recognizing the commitment they bring to proud of this initiative, and trust that it will allow recipients to re- their research and teaching practices. In particular I would like establish scientific projects, strengthen track record and regain to congratulate Professor Carola Vinuesa, who was awarded national and international competitiveness when applying for the inaugural CSL Young Florey Medal for her research in independent external research funding. the immune system and the production of disease fighting antibodies, and Professor Thomas Preiss on the award of the I hope that you will enjoy reading about the recent successes Julian Wells Medal at the Lorne Genome Conference. of the School, and look forward to presenting the companion Research Highlights. JCSMR saw a number of new initiatives come to realization in 2014. In February we launched the National Centre for Professor Simon Foote FFSc (RCPA), FAHMS, FTSE Indigenous Genomics, which aims to establish a national Director, The John Curtin School of Medical Research resource, under Indigenous governance, for appropriate and The Australian National University
Annual Review 2014 3 Organisation Chart
ANU College of Medicine, Biology and Environment ANU College of Medicine, Biology and Environment
The John Curtin School of Medical Research 2014 The John Curtin School of Medical Research 2014
Director Professor Chris Parish (until October) Director Professor Chris Parish (until October) Professor Simon Foote (from October) Professor Simon Foote (from DeputyOctober) Director Professor John Bekkers Deputy Director Professor John Bekkers DEPARTMENTS DEPARTMENTS Genome Immunology The Eccles Pathogens Molecular Genome Immunology The Eccles BiologyPathogens MolecularInstitute of & Immunity Bioscience Biology Institute of & Immunity BioscienceNeuroscience Neuroscience
Professor Professor Professor Professor Professor Professor Professor Professor DavidProfessor ChrisProfessor Greg Carola Angela Dulhunty David Chris Greg TremethickCarola GoodnowAngela DulhuntyStuart Vinuesa Tremethick Goodnow Stuart Vinuesa
ADMINISTRATION ADMINISTRATION School Manager Outreach & Education Director’s Office School Manager Outreach & Education CommunicationsDirector’s Office Communications
Mr Matthew Cousins Dr Madeleine Nicol Dr Anna Cowan Ms Laura Vitler Mr Matthew Cousins Dr Madeleine Nicol Dr Anna Cowan Ms Laura Vitler (until October) (until October) Mrs Ceri Flowers Mrs Ceri Flowers (from October) (from October)
SERVICES AND SUPPORT SERVICES AND SUPPORT ACRF Australian Operations Imaging & Technical Workplace ACRF Australian OperationsBiomolecular Imaging &PhenomicsTechnical Workplace Cytometry Services Health & Biomolecular Phenomics ResourceCytometry FacilityServices Health & Facility Safety Resource Facility FacilityFacility Safety Facility Ms Stephanie Dr Steve Mr Denis Ms Cathy Mr Denis Dr Mark Hayes Ms Stephanie Dr Steve Mr Denis PalmerMs Cathy WinsladeMr Denis CoombesDr Mark HayesGillespie Coombes (until November) Palmer Winslade Coombes Gillespie Coombes (until November) Mr David Mr David Mann Mann (from November) (from November)
4 The John Curtin School of Medical Research Committees
Executive Committee Operations Committee Workshop Committee Professor John Bekkers (until October) (until October) Mr Matthew Cousins Dr Frank Brink (from May) Mr Denis Coombes Dr Anna Cowan (until October) Mr Denis Coombes Professor Angela Dulhunty (Chair) Professor Angela Dulhunty (until October) Mr Matthew Cousins Professor Caryl Hill Professor Simon Foote (from October) Dr Vincent Daria (from February) Ms Michelle Townsend Professor Chris Goodnow (until October) Professor Angela Dulhunty (Chair) Dr Claudio Mastronardi (from October) Dr Suzanne Fowler Gender Equity Committee Dr Madeleine Nicol (until October) Ms Cathy Gillespie Associate Professor Ehsan Arabzadeh Professor Chris Parish (until October) Dr Mark Hayes Dr Anne Bruestle (from November) Professor Greg Stuart Dr Yalin Liao (from March) Associate Professor Ian Cockburn Professor David Tremethick Ms Stephanie Palmer Dr Lucy Coupland Professor Carola Vinuesa Dr Charani Ranasinghe Dr Julia Ellyard (Chair) Ms Michelle Townsend Ms Mary-Anne Jack (until October) External Relations Mr Dennis Vukoja Dr Rebecca Haddock Mrs Esmee Weil Committee (until October) Associate Professor Brett Lidbury Professor John Bekkers (Chair) (from March) Dr Lisa Miosge Mr Matthew Cousins (from February) Safety Committee Dr Madeleine Nicol Dr Anna Cowan Professor Philip Board (Chair) (until August) Dr Ian Parish Dr Anselm Enders Ms Megan Clydesdale Dr Charani Ranasinghe (until October) Dr Riccardo Natoli Mr Mick Devoy Ms Monika Srivastava Dr Madeleine Nicol Dr Renae Domaschenz Dr Rebecca Sweet Professor Chris Parish (Chair) (until February) Dr Julia Ellyard Professor Carola Vinuesa Professor Thomas Preiss Dr Sonya Glasson (until June) Dr Mark Hayes (from July) Group Leaders Forum Dr Peter Milburn (until October) Ms Suzy Pace Dr Krisztina Valter (Chair) (from September) Professor Carola Vinuesa (Chair) All Group Leaders and Laboratory Leaders belong to the Group Leaders Forum, Animal Users Committee which meets monthly to discuss matters of Associate Professor Ruth Arkell (RSB) importance relating to JCSMR Dr Anneke Blackburn Mr Anthony Barker (ex officio) (from October) Education Committee Professor Philip Board Associate Professor Ehsan Arabzadeh Ms Katrina Bowditch (ex officio) Professor John Bekkers Mr Ken Chau (ex officio) Dr Anneke Blackburn Dr Lucy Coupland Dr Anna cowan (chair) Professor Angela Dulhunty Professor simon easteal Dr Suzanne Fowler (ex officio) Miss Preethi eldi Professor Caryl Hill Professor chris Parish Associate Professor Guna Karupiah Mr Roy Ramiscal Professor Klaus Matthaei Dr Riccardo Natoli Dr Ian Parish Dr Charani Ranasinghe Dr Charmaine Simeonovic Associate Professor Christian Stricker (Chair) Dr Narci Teoh (Canberra Hospital)
Annual Review 2014 5 6 The John Curtin School of Medical Research Community
Launch of the National Centre for Indigenous Genomics The Judith Whitworth Fellowship The 2nd Annual Dinner of The John Curtin Medical Research Foundation Launch of the Centre for Personalised Immunology Welcome to the Centenary Chair in Cancer Research The Sarah Grace Sarcoma Foundation The John James Foundation Tony Ayers Prize Open Day The JCSMR Director’s Christmas Morning Tea Our Community
Annual Review 2014 7 Launch of the National Centre for Indigenous Genomics
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A new national centre for research into Indigenous health will help 1. inaugural Governance Board of the National Centre for Indigenous Genomics (front) ANU DVC (Research) Professor Margaret Harding, Board Chair Mr Mick close the gap on Indigenous health and life expectancy, with the Gooda, Dr Misty Jenkins launch of the National Centre for Indigenous Genomics in February (back) Professor Mick Dodson, Dr Emma Kowal, Professor Simon Easteal, Professor Don Chalmers with Dr Cressida Fforde (2nd from the right). 2014 at JCSMR. Absent: Professor Ian Anderson The National Centre for Indigenous Genomics (NCIG) aims to 2. Mr Mick Gooda 3. Professor Mick Dodson, Dr Misty Jenkins, Ms Anne Evers, Ms Pip Deveson establish a national resource, under Indigenous governance, for and Mr Mick Gooda appropriate and respectful genetic and genomic research that will 4. NCIG Director Professor Simon Easteal benefit Indigenous Australians. The inaugural NGIC Governance Board is chaired by Aboriginal and Torres Strait Islander Social Justice Commissioner Mr Mick Gooda.
8 The John Curtin School of Medical Research THE INAUGURAL JUDITH WHITWORTH FELLOWSHIP AT JCSMR
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The Judith Whitworth Fellowship for Gender Equity in Science was 1. ANU Vice-Chancellor Professor Ian young with ACT Chief Minister Ms Katy Gallagher, Emerita Professor Judith Whitworth and JCSMR Director launched at JCSMR in April. The inaugural Fellowship was awarded Professor Chris Parish at the ceremony to launch the inaugural Judith Whitworth to Dr Julia Ellyard in November. Fellowship 2. Professor Judith Whitworth The Fellowship has been established to support a young scientist 3. inaugural Judith Whitworth Fellowship recipient Dr Julia Ellyard and ACT Chief Minister Ms Katy Gallagher with Professor Judith Whitworth who has experienced a break in their research career due to 4. Ms Katy Gallagher, Chair of The John Curtin Medical Research Foundation Board maternity or parental leave and will provide up to two years of salary dr Cameron Webber, and Dr Julia Ellyard and research support. It is envisaged that this will allow the recipient to re-establish scientific projects, strengthen track record and regain national and international competitiveness when applying for independent external research funding. The Fellowship, named in honour of Emerita Professor Judith Whitworth, past director of the JCSMR, and supported by JCSMR and The John Curtin Medical Research Foundation is believed to be the of its kind to be established at an Australian University.
Annual Review 2014 9 THE JOHN CURTIN MEDICAL RESEARCH FOUNDATION 2ND ANNUAL DINNER
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Nobel Laureate Professor J Robin Warren provided fascinating 1. Chair of the JCMRF Board Dr Cameron Webber, Nobel Laureate Professor J Robin nd Warren and ANU Vice-Chancellor Professor Ian Young insights into his work when interviewed by Mr Ken Begg at the 2 2. (l-r) Mr Phil Greenwood, Dr Cameron Webber, Mr Brian Acland, Mr Mark Sullivan, Annual Dinner of the The John Curtin Medical Research Foundation Professor J Robin Warren, Professor Paul Smith and Dr Jeff Harmer in August. 3. Ms Janet Henry, Ms Marilyn Fenner and Ms Diana Lipscombe 4. Nobel Laureate Professor J Robin Warren was interviewed by JCMRF Board Held at University House, the Dinner was a huge success, and Member Mr Ken Begg included raffles, silent auctions and entertainment. Thanks to generous supporters the John James Foundation and Mr Ron and Mrs Janice Parker, funds were donated at the dinner to finalise the purchase of an intravital microscope to be used in research projects on cancer, malaria prevention and the study of autoimmune diseases at ANU. For more information about The John Curtin Medical Research Foundation please visit: jcmrf.anu.edu.au
10 The John Curtin School of Medical Research LAUNCH OF THE CENTRE FOR PERSONALISED IMMUNOLOGY
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Assistant Minister for Health, Senator Fiona Nash, launched The 1. directors of the Centre for Personalised Immunology, Professor Carola Vinuesa and Professor Matthew Cook Centre for Personalised Immunology at JCSMR by on Monday 28 2. At the launch of the Centre for Personalised Immunology: April, 2014. (front row) ANU Vice-Chancellor Professor Ian Young, CPI Director Professor Carola Vinuesa, Senator Fiona Nash, CPI Director Professor Matthew Cook, JCSMR The principal objective of the Centre for Personalised Immunology director Professor Chris Parish, ANU Deputy Vice Chancellor (Research) Professor Margaret Harding. (Back row) Dr Dan Andrews, Mr Matthew Field and Professor is to understand pathophysiological pathways in patients presenting stephen Alexander with immunological disease, in order to make diagnoses more 3. senator Fiona Nash, Professor Chris Parish, Professor Carola Vinuesa, Professor Matthew Cook and Professor Ian Young accurate, and treatment more effective. 4. senator Fiona Nash officially launches the Centre for Personalised Immunology at jCSMR in April 2014 The Centre aims to help people with immune diseases by discovering causative genetic variation, with the goal of delivering treatment strategies targeted to the individual.
Annual Review 2014 11 WELCOME TO THE CENTENARY CHAIR IN CANCER RESEARCH PROFESSOR ROSS HANNAN
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The Australian National University and the ACT Government 1. ACT Chief Minister Ms Katy Gallagher with newly appointed Centenary Chair in Cancer Research, Professor Ross Hannan announced the appointment of distinguished medical researcher 2. john Curtin Medical Research Foundation (JCMRF) Board Member Dr Peter Jeffery Professor Ross Hannan as the inaugural Centenary Chair in Cancer with Mrs Joanna Webber and JCMRF Chair Dr Cameron Webber OAM at the Welcome for the Centenary Chair in Cancer Research at JCSMR Research in November 2014. 3. jCSMR Director Professor Simon Foote with ACT Chief Minister Ms Katy Gallagher 4. Newly appointed Centenary Chair in Cancer Research, Professor Ross Hannan The Centenary Chair is a new position, focused on researching new addresses guests at the welcome reception treatments for cancer patients and fostering collaboration between Canberra medical specialists and scientists at The John Curtin School of Medical Research and across ANU. The Centenary Chair is a joint project of ANU and the ACT Government, established to celebrate the Centenary of Canberra, which took place in 2013. The ACT Government provided $1.5 million to help fund the position.
12 The John Curtin School of Medical Research THE SARAH GRACE SARCOMA FOUNDATION SCHOLARSHIP AT JCSMR
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In the fight to ‘Kick Sarcoma’, The Sarah Grace Sarcoma 1. Board members of the Sarah Grace Sarcoma Foundation, Australian Paralympian Ms Ellie Cole and Mr Hugh Archer, present a cheque to ANU DVC (Research) Foundation has been tirelessly fundraising in Australia and Professor Margaret Harding in February Singapore to support sarcoma research at JCSMR, and currently 2. dr Grace Moshi and Scholarship recipient Mr JinSoo Yoon 3. jazzy (left) and Nadia (right) travelled to JCSMR from Singapore to present a further funds a named PhD Scholarship at the School. cheque for $53,000 to Professor Chris Parish, JCSMR Director Professor Simon foote, Mr JinSoo Yoon and Dr Lucy Coupland from Sarah Grace Sarcoma Mr JinSoo Yoon is the first recipient of that scholarship, studying in foundation in November the Department of Immunology under the supervision of Professor 4. Mr JinSoo Yoon expressed his thanks for the efforts of the Sarah Grace Sarcoma foundation, and said it made him even more determined to work towards an Chris Parish and Dr Lucy Coupland. understanding of sarcoma metastasis
Annual Review 2014 13 AWARD OF THE INAUGURAL JOHN JAMES FOUNDATION TONY AYERS PRIZE FOR EXCELLENCE IN TRANSLATIONAL MEDICINE
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The John James Foundation has established a Prize for Excellence 1. Dr Anneke Blackburn with her Family after the ceremony 2. Dr Anneke Blackburn, Dr James D’Rozario, Dr Lucy Coupland and Chair of the John in Research in Translational Medicine at the ANU College of james Foundation Professor Paul Smith Medicine, Biology and Environment in honour of long term Board 3. Ms Eleanor Hing Fay, ANU Vice Chancellor Professor Ian Young, CEO of the John james Foundation Mr Phil Greenwood, and Dean of the ANU College of Medicine member Mr Tony Ayers AC. The Prize is awarded to an Early – Mid Biology and Environment Professor Kiaran Kirk Career Research Scientist within CMBE who has made a most 4. Dean of the ANU College of Medicine Biology and Environment Professor Kiaran Kirk and Chair of the John James Foundation Professor Paul Smith present the inaugural significant contribution to Translational Research, over the course of Tony Ayers Prize to Dr Anneke Blackburn their research career. The inaugural Tony Ayers Prize was awarded in October 2014 to Dr Anneke Blackburn, Department of Molecular Bioscience, JCSMR, who presented the Tony Ayers Lecture: Targeting cancer cell metabolism with dichloroacetate.
14 The John Curtin School of Medical Research OPEN DAY AT JCSMR 2014
Open Day at JCSMR takes place in August every year. Everyone in our local community is warmly invited to visit us on Open Day to see inside our laboratories, take a Discovery Tour of our building, talk with a scientist about their work, and hear about our important research in areas including cancer, diabetes, vision, autoimmune disease, malaria prevention and more. For information about our next Open Day, please visit jcsmr.anu.edu.au
Annual Review 2014 15 DIRECTOR’S CHRISTMAS MORNING TEA FOR FRIENDS AND SUPPORTERS OF JCSMR
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Every year the Director hosts a Christmas morning tea to celebrate 1. Professor Carola Vinuesa with John Curtin Medial Research Foundation Board members Ms Marilyn Fenner the successes of the past year, and to thank friends of JCSMR for 2. Mr Michael Dobbie, Ms Janet Henry, JCSMR Director Professor Simon Foote, Ms their continued interest in our work, and support for our research. Marilyn Fenner and Mrs Joanna Webber 3. dr Peter Gibson, Treasurer of the Canberra Medical Society presents a cheque to In December 2014, Committee members of the Canberra Medical Professor Simon Easteal, Director of the National Centre for Indigenous Genomics 4. jCSMR Director Professor Simon Foote, Mr Garry Humphries, Professor Carola Society attended the morning tea to present a cheque in support of Vinuesa and Chair of the John Curtin Medical Research Foundation Dr Cameron the newly established National Centre for Indigenous Genomics at Webber at the Director’s Christmas Morning Tea JCSMR.
16 The John Curtin School of Medical Research OUR JCSMR COMMUNITY
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1. The 2014 ACT Final of the Australasian Brain Bee Challenge was won by Shruthisri sridharan, of Burgmann Anglican School, picture here with Professor Greg Stuart, head of the JCSMR Eccles Institute of Neuroscience 2. dr Jason Potas, Mr Michael Bootes and Dr Charani Ranasinghe at a morning tea to meet the Board of the Gordon and Gretel Bootes Foundation 3. Ms Emilie Rohan, Ms Dianne Garner, and Dr Corinne Carle at the Bootes foundation morning tea at JCSMR 4. Members of The Canberra Ionians Group, who visited the Cancer Metabolism and Genetics Laboratory headed by Dr Anneke Blackburn (far right) in August 5. To celebrate International Women’s Day in March, Ms Joy Burch, ACT Minister for Women and ACT Minister for Youth hosted a ‘Girls in Science’ morning tea at JCSMR 6. Ms Joy Burch addresses young women from Canberra High Schools and Colleges as part of the Girls in Science event held in conjunction with International Women’s Day in March
Annual Review 2014 17 OUR JCSMR COMMUNITY
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1. National Youth Science Forum students visited JCSMR laboratories in January 2. in October, JCSMR hosted a special scientific symposium to pay tribute to Philip Board’s remarkable contribution to Australian and international Science: The 15th Frank and Bobbie Fenner Conference: Professor Philip Board Symposium. (l-r) Professor Bengt Mannervik, Associate Professor Aaron Oakley, Associate Professor Marco Casarotto, Professor Phil Board, Dr Lars Jermiin, Professor Angela Dulhunty, Dr Jack Flanagan, Professor Michael Parker, Dr Rohan Baker and Professor Jane Dahlstrom 3. Executive members of the Tokyo Medical and Dental University, led by Professor Yoshi Eishi, visited JCSMR 4. Mr Ray and Mrs Alice Pelham-Thorman with ANU Alumnus Professor Yoshinobu Eishi, now Dean of Medicine at Tokyo Medical and Dental University, renewing a friendship which began while Professor Eishi was a student at JCSMR 5. Australian Federal Minister for Health The Hon. Mr Peter Dutton’s visit to the jCSMR Department of Immunology 6. in December, staff and students gathered to celebrate the retirement of four of our longstanding colleagues – Professor Klaus Matthaei, Professor Caryl Hill, Professor Philip Board and Professor Bruce Walmsley. 119 years, 99 students and over 700 publications. What an achievement!
18 The John Curtin School of Medical Research Annual Review 2014 19 20 The John Curtin School of Medical Research Staff and Student Achievements
Graduates Prizes, Honours and Awards
Annual Review 2014 21 GRADUATes
PhD Daniel John Chaston ShuYi (Sophie) Han The Role of Endothelial Connexin40 in the Histone Variant H2A.Z: A Master Regulator Rizalyn Sarda Albarracin Regulation of Arterial Function and Blood of Epithelial-to-Mesenchymal Transition The Therapeutic Potential of 670nm Light Pressure in Retinal Degeneration Amy Dianne Hanna Fui Jiun Choong Mechanisms of Anthracycline-induced Hans Christoph Tobias Bock Roles for Islet Heparan Sulfate and Dysfunction of Ca2+ Handling Proteins in The Impact of Calcium-Activated Heparanase in Islet Transplantation the Heart Potassium Channels on Dendritic Excitability in Cortical Layer 5 Pyramidal Bevan Gang Carly Jane Hynes Neurons Targeting Cancer Metabolism Investigating the Complexities of MicroRNA-Target Interactions in Cardiac Soek-Yeng Chan Mary Ann Go Biology Role of DOCK8 and hnRNPLL in CD8 Precise Optical Manipulation Techniques T Cell Survival for Exploring Neuronal Function Jing Ji Effects of Heat Labile Enterotoxin B Subunit on Murine Dendritic Cells
22 The John Curtin School of Medical Research Susan Kaye Morton The Role of Endothelial Connexin40 in the Regulation of Activity-Dependent Blood Pressure Elevation Robyn Tricia Rebbeck Interactions between the Dihydropyridine Receptor Beta1A Subunit and the Ryanodine Receptor from Skeletal Muscle Zahra Sabouri-Thompson Positive and Negative Selection of Antibodies in Germinal Centres Monika Srivastava Regulation of miRNA Homeostasis by Roquin Andrea Stojakovic Long-Term Effects of LPS and High-Fat Diet on Dopaminergic Neurodegeneration Dijana Townsend Role of Eosinophils in Respiratory Syncytial Virus Infection Danushka Kumara Wijesundara HIV-1 Vaccine Development: Evaluating Mechanisms of CD8+ T Cell Avidity Hermia Willemse Towards Understanding EC Coupling Protein Expression with Age Elize Wium Identifying the in vitro Interactions between the Skeletal Muscle Ryanodine Receptor, Triadin and Calsequestrin Mehmet Yabas B Cell Deficiency and Anaemia Caused by Mutations in the Murine Atp11c Gene
MPhil Scott Lewis Jones Jasmine Li Jayashree Ravichandran On the Function of Somatic and Dendritic Nuclear Protein Kinase C-theta and Role of IL-17 in HIV Specific CD8+T Cell SK Channels in Cortical Pyramidal Permissive Chromatin States Co-ordinate Immunity Neurons Transcriptional Memory Responses in Human T Cells HieRin Lee MNeuroscience (Research) Linwei Li The Development of Seahorse Vision: Farhia Haque Morphological and Behavioural Aspects In Vitro Exploration of Interactions Between Junctin and the Ryanodine Receptor from Indumathi Ravi Suhyun Lee Skeletal and Cardiac Muscle Conor Owens Walton Long-Term Metabolic Effects of Stress Sally Jane Mapp and Antidepressants: A Novel Paradigm of Antidepressant-Induced Weight Gain in Genetic Mutations Promoting the Post-Stress Acclimation Period Autonomous B cell Proliferation Ameet Kumar Mishra Leptin: Linking Obesity to Breast Cancer Progression
Annual Review 2014 23 prizes and awards
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Dr Rizalyn Sarda Albaraccin Ms Fui Jiun Choong Ms Sarita Dhounchak ANU Alumni Award – 2014 Postgraduate Canberra Hospital Private Practice Fund ANU CMBE Prize for Best Poster Student of the Year Award for Best Student Oral presentation: Presentation: Beta cell heparan sulfate Molecular insights into the loss of heparan and heparan sulfate proteoglycan loss in Mr Hannes Bergann sulfate (HS) during islet isolation and Type 2 Diabetes, The Australian Society HS recovery after islet transplantation, for Medical Research (ASMR) ACT Branch Australasian Society of Immunology Travel The Canberra Health Annual Research New Investigator Forum, Canberra, ACT Award Meeting, Canberra, ACT Dr Julia Ellyard Dr Anneke Blackburn Dr Stephen Daley The inaugural Judith Whitworth Fellowship The 2014 John James Foundation Tony The Gordon Ada Early Career Researcher for Gender Equity in Science Ayers Prize for Excellence in Translational Award. Presented to an Early Career Medicine, ANU College of Medicine, Researcher at JCSMR who has made Ms Nilisha Fernando Biology and Environment major contributions to biomedical research EMBL Australia Travel Grant to attend the 16th EMBL International PhD Symposium, Heidelberg, Germany
24 The John Curtin School of Medical Research 5 6
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1. Professor Carola Vinuesa was awardee the inaugural Professor Simon Foote Ms Susan Morton CSL Young Florey Medal 2. Nobel Laureate Emeritus Professor Rolf Zinkernagel Elected as Fellow, The Australian International Society of Cardiovascular was awarded the Curtin Medal for 2014 Academy of Health and Medical Sciences Pharmacotherapy Student Travel Grant to 3. Dr Stephen Daley received The Gordon Ada Early attend Experimental Biology 2014, Career Researcher Award for 2014 Appointed Director, The John Curtin 4. Professor Greg Stuart was invited to present the San Diego, CA, USA 4th Annual John Curtin Lecture by JCSMR Director School of Medical Research, ANU Professor Chris Parish 5. Chair of the John James Memorial Foundation Dr Simon Jiang presents the inaugural Tony Ayers Prize for Dr Jason Potas Excellence in Translational Medicine to Dr Anneke Australian Government Postgraduate Blackburn ANU Excellence in Teaching Awards, 6. ANU Alumni Awards – Postgraduate Student of the Scholarship to investigate the development Best Faculty Teacher Phase 1, year – Rizsa Albarracin of systemic lupus erythematosus 7. Professor Thomas Preiss ANU Medical School 8. Dr Julia Ellyard, JCSMR Director Professor Simon foote and Emerita Professor Judith Whitworth Finalist: Your Science in 60 Seconds. following the award of the inaugural Judith Whitworth Dr Yalin Liao Science Meets Parliament fellowship for Gender Equity in Science Travel award to attend the Global Young Scientist Summit, One North, Singapore ANU Early Career Researcher’s (ECR) Travel Award: to attend the EMBL Conference: Complex life of RNA, EMBL Heidelberg, Germany SIEF John Stocker Postdoctoral Fellowship
Annual Review 2014 25 Professor Chris Parish Mr Manu Singh Mr Malinda Tantirigama The Chancellor’s Award for Distinguished Viewer’s Choice Prize for Best Poster, Early Career Researcher Award for Contribution to the University for 2014 The Australian Society for Medical Excellence: UWS Sensory Neuroscience ACT Citizen of the Year 2014 Research (ASMR) ACT Branch New Symposium, University of Western Investigator Forum, Canberra, ACT Sydney, Sydney, NSW Mr Alvin Pratama Ms Rina Soetanto Dr Krisztina Valter- Kocsi ASI travel bursary to attend the 44th Annual Scientific Meeting of the Australasian Society Viewer’s Choice prize for Best Oral Promoted to Associate Professor for Immunology, Wollongong, NSW Presentation, and Prize for Best Poster Elected as a Senior Fellow of Higher – The Australian Society for Medical Education Academy UK Scholarship to attend the Croucher Summer Research (ASMR) ACT Branch New Course 2014: Advances in Immunology in Investigator Forum, Canberra, ACT Inaugural member of the Education Health and Disease, Department of Medicine, Fellowship Scheme committee, ANU the University of Hong Kong, Hong Kong Prize for Best Oral Presentation: The dynamics of miRNA-mRNA targeting during ANU Vice-Chancellor’s Postgraduate cardiac health and disease. EMBL Australia Professor Carola Vinuesa Travel Grant PhD Symposium, Sydney, NSW The inaugural CSL Young Florey Medal for ASI Postgraduate International Travel Award Runner-up, ANU 3-Minute Thesis her research into how the immune system Competition: Mending a broken heart- a produces antibodies to fight disease Professor Thomas Preiss big role for small RNAs. ANU Colleges of Science, ANU, Canberra, ACT The Julian Wells Medal and Lecture, The Lorne Genome Conference, Lorne, VIC Dr Zan-Min Song Dr Jennifer Robertson ANU Excellence in Teaching Awards, Best Faculty Teacher Phase 1, Poster Prize, Runner up – The Australian ANU Medical School Society for Medical Research (ASMR) ACT Branch New Investigator Forum, Canberra, ACT Professor Greg Stuart The 4th Annual John Curtin Lecture in Medical Research ‘Brain Mechanics: The nuts and bolts of how your brain works’
26 The John Curtin School of Medical Research Annual Review 2014 27 28 The John Curtin School of Medical Research Visitors and Collaborations
Research Collaborations and Visitors to the School Visitors to JCSMR present their research findings through Group, Department or School Seminars and workshops, and collaborate with our staff and students in our world-class research facilities. Staff and students at JCSMR continue to enjoy close collaborative ties with other researchers at The Australian National University. In addition, they enjoy scientific associations with colleagues locally, regionally, national and internationally.
Annual Review 2014 29 Visitors
Professor David J Adams Professor Colin Clifford Assistant Professor Christian Health Innovations Research Institute, School of Psychology, The University of Henneberger RMIT University, Melbourne, VIC New South Wales, Sydney, NSW Institute of Cellular Neurosciences, University of Bonn Medical School, Professor Juan-Manuel Anaya Professor Stephen Dalton Bonn, Germany Center for Autoimmune Diseases Department of Biochemistry and Research (CREA), Rosario University, Molecular Biology, The University of Professor Ian Hickie Bogotá, Colombia Georgia, Athens, GA, USA Brain and Mind Research Institute, University of Sydney, Sydney, NSW Dr Anthony Ashton Professor Mathew Diamond University of Sydney, Sydney, NSW International School for Advanced Studies Professor Philip Hugenholtz (SISSA), Trieste, Italy Australian Centre for Ecogenomics, Dr Ulus Atasoy School of Chemistry and Molecular Molecular Microbiology and Immunology, Dr Christian Engwerda Biosciences, University of Queensland, University of Missouri School of Medicine Immunology and Infection Laboratory, Brisbane, QLD and Harry S Truman Veterans Hospital, QIMR Berghofer Medical Research Columbia, MO, USA Institute, Brisbane, QLD Associate Professor Katherine Kedzierska Associate Professor Tony Badrick Associate Professor Lindy Department of Microbiology and Faculty of Health Sciences and Medicine, Fitzgerald Immunology, School of Biomedical Bond University, Gold Coast, QLD School of Animal Biology, The University Sciences, The University of Melbourne, of Western Australia, Crawley, WA Melbourne, VIC Dr Rohan Baker Clinical Genomics, Sydney, NSW Professor Simon Foote Professor Trevor Kilpatrick The Australian School of Advanced Division of Multiple Sclerosis, The Florey Professor Jacques Banchereau Medicine, Macquarie University, Institute for Neuroscience and The The Jackson Laboratory for Genomic Sydney, NSW Melbourne Neuroscience Institute, The Medicine, Farmington, CT, USA University of Melbourne, Melbourne, VIC Professor Paul Foster Dr Vladimir Benes School of Biomedical Sciences and Professor Bostjan Kobe Genomics Core Facility, European Pharmacy, The University of Newcastle, School of Chemistry & Molecular Molecular Biology Laboratory, Newcastle, NSW Biosciences, University of Queensland, Heidelberg, Germany Brisbane, QLD Professor Simon Gandevia Professor John Carver Neuroscience Research Australia, Professor Eddy FY Liew Research School of Chemistry, ANU Sydney, NSW Division of Immunology, Infection and College of Physical & Mathematical Inflammation, University of Glasgow, Sciences, The Australian National Professor Ross D Hannan Glasgow, Scotland University, Canberra, ACT The Peter MacCallum Cancer Centre, Melbourne, VIC Dr Charles H Lineweaver Professor Archie Clements ANU Planetary Science Institute – Mount The National Centre for Epidemiology Professor Edna Hardeman Stromlo Observatory, Research School and Population Health, ANU College of Neuromuscular and Regenerative of Astronomy and Astrophysics, ANU Medicine, Biology and Environment, The Medicine Unit, School of Medical College of Physical and Mathematical Australian National University, Sciences, University of New South Wales, Sciences, The Australian National Canberra, ACT Sydney, NSW University, Canberra, ACT
30 The John Curtin School of Medical Research Professor Kate Loveland Professor Michael S Moore Professor Gordon Smyth Department of Biochemistry & Molecular Program in Law and Philosophy, Division of Bioinformatics, The Walter and Biology and Department of Anatomy College of Law, The University of Illinois, Eliza Hall Institute of Medical Research, and Developmental Biology, Monash Champaign, IL, USA Melbourne, VIC University, Melbourne, VIC Professor Eric Morand Professor Mandyam Srinivasan Dr Yuerui Lu School of Clinical Sciences, Monash Visual and Sensory Neuroscience, Research School of Engineering, ANU Health and Faculty of Medicine, Nursing Queensland Brain Institute, The University College of Engineering and Computer & Health Sciences, Monash University, of Queensland, Brisbane, QLD Science, The Australian National Melbourne, VIC University, Canberra, ACT Professor Seong-Seng Tan Dr Maximilian Muenke Brain Development, The Florey Institute Associate Professor Michele Medical Genetics Branch, National of Neuroscience and Mental Health, Madigan Human Genome Research Institute, Melbourne, VIC School of Optometry & Vision Science, National Institutes of Health, Bethesda, University of New South Wales, Sydney, MD, USA Dr Illa Tea NSW and Save Sight Institute and University of Nantes, Nantes, France Discipline of Ophthalmology, University of Dr Gabe Murphy Sydney, Sydney, NSW Janelia Research Campus, Howard Professor Joseph Trapani Hughes Medical Research Institute, Cancer Cell Death Laboratory, The Peter Dr Germán Manríquez Ashburn, VA, USA MacCallum Cancer Centre, Faculty of Medicine and Faculty of Social Melbourne, VIC Sciences, University of Chile, Assistant Professor Ki Taek Nam Santiago, Chile Department of Materials Science and Dr Richard Ulevitch Engineering, Seoul National University, Department of Immunology and Microbial Professor Justin Marshall Seoul, Korea Science, The Scripps Research Institute, Sensory Neurobiology, Queensland Brain La Jolla, CA, USA Institute, The University of Queensland, Professor Christopher Nolan Brisbane, QLD Diabetes Research Laboratory, Professor Mark von Itzstein Endocrinology Unit, Canberra Hospital, Institute for Glycomics, Griffith University, Dr Jose DeLeon Canberra, ACT Southport, QLD Department of Psychiatry, University of Kentucky, Lexington, KY, USA Professor Virginia Pascual Dr Linda Wakim Center for Inflammation and Autoimmune Department of Microbiology and Professor Sonya Marshall- Diseases and Center for Personalized Immunology, The University of Melbourne, Gradisnik Medicine, Baylor Research Institute, Melbourne, VIC School of Medical Science, Griffith Dallas, TX, USA University, Gold Coast, QLD Professor Wolfgang Weninger Dr Nicholas Price Centenary Institute of Cancer Medicine Professor John Mattick Department of Physiology, Monash and Cell Biology, The University of Garvan Institute of Medical Research, University, Melbourne, VIC Sydney, Sydney, NSW Sydney, NSW Professor Markus Schlaich Laureate Professor Rolf Professor Jason B Mattingley Hypertension and Kidney Disease, Zinkernagel Cognitive Neuroscience, Queensland Baker IDI Heart and Diabetes Institute, The University of Zurich, Brain Institute and The School Melbourne, VIC Zurich, Switzerland of Psychology, The University of Queensland, Brisbane, QLD
Annual Review 2014 31 Collaborations
Ms Nur Diana Anuar, Dr Dr MT Acosta Children’s’ National Professor M Larkum Charité-Humboldt Hospital, Children’s Research Institute University, Neuroscience Research Tatiana A Soboleva and (CRI), Washington, DC, USA Center, Berlin, Germany Professor David Tremethick Genetics of autoimmune disorders Persistent firing in cortical interneurons: An investigation on the role of histone Dr J-M Anaya Centre for Autoimmune Mechanisms and potential variant H2A.Lap1 Diseases Research, University of Rosario, anticonvulsant role Professor P Koopman, J Bowles Bogota, Colombia Dr M McDonnell Institute of and T-L Davidson Institute for Genetics of ADHD Telecommunications Research, University Molecular Bioscience, The University of South Australia, Adelaide, SA Dr M Bellgrove School of Psychological of Queensland, Brisbane, QLD Dr PD Epilepsy in the piriform cortex Gregory and Dr L Zhang Sangamo Sciences, Monash University, BioSciences Inc., Richmond, CA, Melbourne, VIC Dr C Reid Florey Institute, USA Dr R Arkell Research School Genetics of Major Depressive Disorder Melbourne, VIC of Biology, The Australian National and genetics of Morbid Obesity University, Canberra, ACT Professor JE Professor J Licinio and Professor M-L Dr Andrew Bell Dahlstrom Department of Pathology, Wong Translational Medicine, Flinders Canberra Hospital, Canberra, ACT Dr D Studies of otoacoustic emissions from the University, Adelaide, SA and South Andrews and Mr M Field Department of human cochlea Australian Health and Medical Research Immunology, The John Curtin School of Institute, Adelaide, SA Dr W Jedrzejczak Institute of Physiology Medical Research, ANU, Canberra, ACT and Pathology of Hearing, Genetics of substance use disorders Warsaw, Poland Associate Professor Ehsan Dr J DeLeon Department of Psychiatry, Computer modelling of University of Kentucky, Lexington, cochlear mechanics Arabzadeh KY, USA Professor HP Wit University of Whisker sensory system, from receptor Genetics of ADHD Groningen, the Netherlands to behaviour Dr F Levy School of Psychiatry, University Professor M Diamond International of New South Wales, Randwick, NSW, School for Advanced Studies, Trieste, Italy Dr Edward M Bertram and Genetics of Alzheimer’s Disease and mild Professor Chris C Goodnow Contribution of layers 2/3 on sensory cognitive impartment, and genetics processing in mouse barrel cortex of disphemia China-Australia Centre for Phenomics Research Professor L Richards Queensland Brain Dr F Lopera Neurosciences Group, Institute, Brisbane, QLD University of Antioquia, Medellín, Professor H Tang Centre for Infection Neuronal and behavioural correlates Antioquia, Colombia and Immunity, Chinese Academy of choice of Sciences, Institute of Biophysics, China Professor F Westbrook Department Dr Vicki Athanasopoulos of Psychology, University of New South Dr Anneke C Blackburn Identifying protein-protein interactions Wales, Sydney, NSW with an unnatural photocrosslinking Mouse mammary tumour The role of context in sensory processing amino acid. susceptibility loci Dr N Price Department of Physiology, Professor G Otting Research School of Professor DJ Jerry Veterinary Monash University, Clayton, VIC Chemistry, The Australian National and Animal Sciences, University of University, Canberra, ACT Massachusetts, Amherst, MA, US Associate Professor Targeting breast cancer with Mauricio Arcos-Burgos Professor John M Bekkers dichloroacetate and the mitochondrial toxin PENAO Genetics of ADHD and Excitability and hyperexcitability of neural circuits in the rodent piriform cortex Professor PJ Hogg and Dr PJ Dilda disruptive behaviours Lowy Cancer Research Centre, University Dr M Muenke National Human Genome Professor S Nelson Brandeis University, of New South Wales, Sydney, NSW Waltham, MA, USA Professor G Research Institute, National Institutes of Targeting of Two Aspects of Metabolism Health, Bethesda, MD, USA Augustine National University of Singapore, Singapore; Korea Institute (TOTAM) for Cancer Therapy Dr M Casas, Dr J-A Ramos-Quiroga of Science and Technology, Seoul, Professor JE Dahlstrom Anatomical and Dr M Ribases Vall d’Hebron South Korea; Lee Kong Chian School of Pathology, ACT Pathology, Canberra Institut de Recerca (VHIR) through the Medicine, Singapore Hospital and ANU Medical School, The International Multicentre Persistent ADHD Australian National University, Canberra, Collaboration Consortium (IMPACT), Neural circuits for odour-processing in the rodent piriform cortex ‘in vivo’ ACT Associate Professor D Yip Barcelona, Spain Medical Oncology, Canberra Hospital, Canberra, ACT and ANU Medical School,
32 The John Curtin School of Medical Research The Australian National University, Dr Anne Breustle Dr A Bjorksten Department of Pain and Canberra, ACT Anesthesia, Royal Melbourne Hospital, Antigen receptor mediated depletion 13 15 Melbourne, VIC Isotopic signature of C and N natural of FOXP3 in induced regulatory T abundance in breast cancer lymphocytes via PTPN2 and FOXO1 Mr Aaron Chuah Dr I Tea University of Nantes, Dr E Bothur and Professor M Lohoff Nantes, France Institute for Medicine, Microbiology and Alpine Frog and Bettong Genotyping A Centre for Oncology Education and Hygiene, Philipps-University, by Sequencing Research Translation (CONCERT) Marburg, Germany Dr S Banks Fenner School of Environment Professor P deSouza Liverpool The role of MALT1 in autoimmunity and Society, The Australian National Hospital, Sydney, NSW and tolerance University, Canberra, ACT Dr D Brenner Department of Infection Brachypodium, Eucalypt & Coconut Dr Anneke C Blackburn and and Immunity, Luxembourg Institute Genotyping by Sequencing Dr Lucy Coupland of Health, Luxembourg Professor Professor J Borevitz Research School of TW Mak Campbell Family Institute for Biology, The Australian National University, Phase 2 Clinical Trial of Dichloroacetate in Breast Cancer Research, Ontario Cancer Canberra, ACT Plateau Phase Myeloma Institute, Princess Margaret Hospital, Toronto, ON, Canada Dr T Calzascia Australian Native Plants Dr S Bennett, Dr J D’Rozario and Dr P Novartis Institutes for BioMedical Genotyping by Sequencing Crispin Haematology, Canberra Hospital, Research, Novartis Basel, Switzerland Canberra, ACT Dr E James Royal Botanic Gardens, Antioxidant glutathione in autoimmunity Melbourne, VIC Professor Philip G Board and cancer Australian Alpine Plant Genotyping Dr I Harris and Professor TW Mak By Sequencing Determination of glutathione Campbell Family Institute for Breast Dr A Miller Departments of Zoology and transferase structures Cancer Research, Ontario Cancer Genetics, Faculty of Science, The University Professor M Parker St Vincent’s Institute, Princess Margaret Hospital, of Melbourne, Melbourne, VIC Toronto, ON, Canada Dr D Brenner Medical Research Institute, Pelargonium Genotyping by Sequencing Melbourne, VIC Department of Infection and Immunity, Luxembourg Institute of Associate Professor A Nicotra, Research Function of Zeta and Omega class GSTs Health, Luxembourg School of Biology, The Australian National Professor MW Anders Department of University, Canberra, ACT UVRAG in Autoimmunity Pharmacology and Physiology, University Oil Palm Genotyping by Sequencing of Rochester Medical Centre, Rochester, Dr S Afzal and Professor TW Mak NY, US Campbell Family Institute for Breast Dr M Ithnin Malaysian Palm Oil Board, Cancer Research, Ontario Cancer Kuala Lumpur, Malaysia Structure of γ-glutamyl cyclotransferase Institute, Princess Margaret Hospital, Kelp and Seaweed Genotyping Associate Professor A Oakley School Toronto, ON, Canada by Sequencing of Chemistry, University of Wollongong, Wollongong, NSW Dr C Fraser Fenner School of Environment Dr Marco G Casarotto and Society, The Australian National The expression of γ-glutamyl University, Canberra, ACT cyclotransferase in human cancer Molecular recognition of the ryanodine receptor Professor JM Waters, Department of Professor Y Eishi and Dr K Takemura Zoology, University of Otago, New Zealand Department of Human Pathology, Tokyo Dr M Samso Department of Physiology Medical and Dental University, and Biophysics, VCU School of Medicine, Stonefly Genotyping by Sequencing Tokyo, Japan Richmond, VA, US Dr N Dussex, Department of Zoology, The role of Omega class GSTs in Design and development of M2 influenza University of Otago, New Zealand TLR4 signalling A inhibitors Choerodon Genotyping by Sequencing Professor L O’Neill and Dr R Coll Professor Wenhui Hu Guangzhou Ms K Cure School of Plant Biology, School of Biochemistry and Immunology, Institute of Biomedicine and Health, University of Western Australia, Perth, WA Trinity Biomedical Sciences Institute, Chinese Academy of Sciences, Science Craspedia and Ozothamnus Genotyping Trinity College, Dublin, Ireland Park, Guangzhou, China by Sequencing Interactions between the alpha and beta subunits of the dihydropyridine receptor Dr A Schmidt-Lebuhn CSIRO Plant Industry Canberra, ACT Assistant Professor C Perez Brigham and Women’s Hospital, Harvard Cotton RNAseq differential expression analysis University, Boston, MA, USA Associate Dr C MacMillan CSIRO Plant Industry, Professor A Oakley Department of Canberra, ACT Chemistry, University of Wollongong, Wollongong, NSW
Annual Review 2014 33 Arabidopsis Variant Calling in Amplicons Adelaide Hospital, Adelaide, SA Dr Professor Matthew C Cook, Dr J Barrero, CSIRO Plant Industry, M French School of Pathology and Professor Chris C Goodnow Canberra, ACT Laboratory Medicine, The University of Western Australia, Perth, WA Dr S Choo and Professor Carola G Myrtle rust RNAseq transcriptome assembly Royal Melbourne Children’s Hospital, Vinuesa and differential expression analysis Melbourne, VIC Professor D Campbell Dr C Kulheim, Research School of Biology, and Dr S Mehr The Children’s Hospital Australian point mutation in systemic The Australian National University, at Westmead, Westmead, NSW Dr S lupus erythematosus (APOSLE) study Canberra, ACT Riminton Department of Immunology, Professor P Gatenby Canberra Concord Repatriation General Hospital, Murine RNAseq differential Hospital, Canberra, ACT Dr S Adelstein Concord, NSW Dr D Fulcher Department expression analysis and Dr R Garsia Department of of Immunopathology, The Children’s Immunology, Royal Prince Alfred Hospital, Dr H Tay School of Biomedical Sciences Hospital at Westmead, Westmead, NSW Camperdown, NSW Dr D Mallon and Pharmacy, Newcastle University, Genomic medicine for human Fremantle Hospital, Fremantle, WA Dr Newcastle, NSW immune deficiency S Alexander The Children’s Hospital at Westmead, Westmead, NSW Dr S Dr D Tscharke Research School of Riminton Department of Immunology, Mr Aaron Chuah, Emeritus Biology, The Australian National University, Concord Repatriation General Hospital, Canberra, ACT Dr D Fulcher Department Professor Trevor Lamb and Concord, NSW Dr D Fulcher of Immunopathology, The Children’s Dr Hardip Patel Department of Immunopathology, Hospital at Westmead, Westmead, NSW The Children’s Hospital at Westmead, RNAseq retinal gene comparative A randomised trial to assess antibody and Westmead, NSW transcriptomics and TriPyGDU browser cellular responses to hepatitis B vaccine Emeritus Professor D Hunt Lions Eye in patients with chronic kidney disease Institute & University of Western Australia (VaccineCKD) Dr Lucy Coupland Oceans Institute, The University of Dr K Karp Canberra Hospital, Mechanisms and novel treatment Western Australia, Perth, WA Canberra, ACT avenues for auto-immune cytopenias CCR5 expression on B cells in Dr J D’Rozario and Dr P Crispin Associate Professor Ian immune deficiency Haematology Department, Canberra Hospital, Canberra, ACT Cockburn Professor H Korner University of Characterisation of erythrocyte Imaging the CD8+ T cell response to Tasmania, Hobart, TAS abnormalities in hemoxygenase-1 malaria parasites in the liver STAT3 and hyper IgE syndrome deficient mice Dr R Amino and Dr R Menard Institut Dr S Tangye Garvan Institute of Medical Professor R Stocker, Dr R Winter and Pasteur, Paris, France Assistant Professor Research, Sydney, NSW Dr S Fraser Sydney Medical School, The V Ganusov Theoretical Immunology University of Sydney, Sydney, NSW Laboratory, University of Tennessee, Knoxville, TN, USA Professor Matthew C Cook Understanding B cell responses to malaria and Dr Stephen Daley Dr Lucy Coupland and Dr vaccine antigens at the single cell level Immune response after adult thymectomy Anneke Blackburn Dr R Seder Vaccine Research Centre, Professor G Chong Canberra Hospital, Dichloroacetate in Multiple Myeloma National Institute of Allergy and Infectious Canberra, ACT Dr J D’Rozario, Dr S Bennett and Dr Diseases, National Institutes of Health, P Crispin Haematology Department, Bethesda, MD, USA Dr F Ndungu Canberra Hospital, Canberra, ACT Kenya Medical Research Institute, Professor Matthew C Cook KEMRI-Wellcome Trust Research and Professor Chris C Programme, Kilifi, KenyaProfessor Goodnow Dr Stephen Daley K Marsh Nuffield Department of Pulmonary hypertension caused by a Medicine, University of Oxford, Cell of origin of B cell novel ENU-induced variant of Tomm40 Oxford, UK Non-Hodgkin’s lymphoma Professor L Arnolda The Canberra Dr D Talaulikar Canberra Hospital, Professor Matthew C Cook Hospital, Canberra, ACT and ANU Canberra, ACT Australian and New Zealand Antibody Medical School, The Australian National Deficiency Allele (ANZADA) study University, Canberra, ACT Dr S Adelstein and Dr R Garsia Department of Immunology, Royal Prince Alfred Hospital, Camperdown, NSW Dr T DeMalmanche HAPS Immunology, Newcastle, NSW Dr P Hissaria Royal
34 The John Curtin School of Medical Research Dr Vincent Daria Assistant Professor M Samso Effects of the beta subunit of the DHPR on Department of Physiology and Biophysics, excitation-contraction coupling Brain-on-a-chip Virginia Commonwealth University, Professor M Schneider Biochemistry and Professor HA Bachor and Professor Richmond, VA, USA Molecular Biology, University of Maryland C Jagadish Research School of Physics Abnormalities in ryanodine receptor activity School of Medicine, Baltimore, MD, USA and Engineering, The Australian National in human heart failure University, Canberra, ACT Professor C dos Remedios Department Dr Julia Ellyard and Adaptive wavefront correction of efficient of Anatomy, The University of Sydney, Professor Carola Vinuesa delivery of light through brain tissues Sydney, NSW Dr S Lee Research School of Single channel activity of RyRs from normal Loss-of-fuctional variants in AIRE Engineering, The Australian National human and DM1 muscle Professor P Peterson and Dr M University, Canberra, ACT Professor K North and Dr N Clarke Saare Institute of Molecular and Cell Synthesising photo-switchable Discipline of Paediatrics and Child Health, Biology, University of Tartu, Estonia nanoparticle agents for cell imaging The Children’s Hospital at Westmead, The IFN-alpha secretion in SLE and analysis University of Sydney, Sydney, NSW Professor P Hertzog Centre for Innate Dr A Tricoli Research School of New cardiac ryanodine receptor inhibitors Immunity and Infectious Diseases, Engineering, The Australian National for the treatment of heart failure Monash Institute of Medical Research, University, Canberra, ACT Professor L Arnolda Canberra Hospital, Melbourne, VIC Analysing Soft-matter interactions using Canberra, ACT and ANU Medical School, multiple beam optical tweezers The Australian National University, Dr Anselm Enders Professor E Sevick Research School Canberra, ACT Analysis of the putative phospholipid of Chemistry, The Australian National Mutations in CLIC-2 proteins leading to transporter ATP11C University, Canberra, ACT ryanodine receptor channelopathy heart failure and intellectual deficit Professor S Broer Research School of Biology, The Australian National University, Professor Angela Dulhunty Professor C Schwartz and Dr E Axelov Canberra, ACT JC Self Research Institute of Human Ryanodine receptor regulation in health Analysis of liver tumor development in and disease Genetics, Greenwood Genetic Center, Greenwood, SC, USA and Department ATP11C deficient mice Dr NA Beard Centre for Research in of Physics, Computational Biophysics Professor N Teoh Canberra Hospital, Therapeutic Solutions, University of and Bioinformatics, Clemson University, Canberra, ACT Canberra, ACT Clemson, SC, USA Analysis of MAIT cell development and Various aspects of ryanodine Actions of φ-LITX-Lw1a on ryanodine function in PLZF mutant mice receptor physiology receptors Professor D Godfrey Department of Dr D Laver Hunter Medical Research Professor C Huang and Dr S Salvage Microbiology and Immunology, University of Institute, University of Newcastle, Department of Physiology, Development Melbourne, Melbourne, VIC Newcastle, NSW and Neuroscience, University of Analysis of MHC invariant chain processing Cambridge, Cambridge, UK Contribution of splicing defects and and development of dendritic cells in mutations on ryanodine receptors function Mutations in the ryanodine receptor leading SPPL2A deficient mice to CPVT and atrial fibrillation Professor RT Dirksen and Dr L Wei Professor J Villadangos Department of Department of Pharmacology and Dr J Smith and Professor P Alewood Microbiology and Immunology, University of Physiology, University of Rochester Medical Institute for Molecular Biosciences, The Melbourne, Melbourne, VIC Centre, Rochester, NY, USA University of Queensland, St Lucia, QLD Genetic analysis of humans with Actions of triadin and calsequestrin on The roles of calsequestrin in fast and slow immunodeficiency of unknown aetiology excitation-contraction coupling twitch skeletal muscle Professor H Eibel and Professor S Ehl Professor RT Dirksen and Dr L Wei Professor F Protasi CeSI, Center for Centre for Chronic Immunodeficiency, Department of Pharmacology and Research on Ageing Department of Freiburg, Germany and Professor K Physiology, University of Rochester Medical Neuroscience and Imaging Università Schwarz University of Ulm, Ulm, Germany Centre, Rochester, NY, US Gabriele d’Annunzio, Chieti, Italy CPVT mutations in the cardiac RyR and Effects of aging on the distribution of CCD mutations in the skeletal RyR excitation-contraction coupling proteins in Professor T Wagenknecht and Dr Z human skeletal muscle Liu Wadsworth Center, New York State Professor P Smith Trauma and Department of Health, Albany, NY, US Orthopaedic Research Unit, Canberra The 3D location of the binding domains Hospital, Canberra, ACT in RyR1
Annual Review 2014 35 Professor Chris C Goodnow Australian Phenomics Network Project: Professor Chris C Goodnow Mouse Pathology Human antibody repertoires and Professor Carola G Professor John Furness Autonomic Dr D Dunn-Walters King’s College, and Sensory Neuroscience Laboratory, Vinuesa London, UK Professor D Kipling Cardiff University of Melbourne, Melbourne, VIC Immunity and Infection University, Cardiff, UK Professor N Dear Research and Genomics Consortium Biomedical Services, South Australian Dr R Cornall Nuffield Department of Professor Chris C Goodnow Health and Medical Research Institute, Clinical Medicine, Oxford University, and Dr Edward M Bertram Adelaide, SA Oxford, UK Professor J Bell The Weatherall Institute of Molecular Medicine, Mutagenetix – A database of mutations Australian Phenomics Network Project: Australian Phenome Bank Cryopreservation Oxford University, Oxford, UK Professor and phenotypes induced by ENU W Britton and Dr B Saunders Centenary Professor B Beutler University of Texas Dr P Sharp Animal Resources Centre, Institute of Cancer Medicine and Cell Southwestern Medical Center, Dallas, Murdoch University, Canningvale, WA Biology, The University of Sydney, Sydney, Texas, USA Australian Phenomics Network Project: NSW Professor M Lathrop National Centre for Genotyping, Evry, France International Mouse RNAi technologies Phenotyping Consortium Professor K Simpson Gene Regulation Professor S Brown MRC Harwell, Laboratory, Peter MacCallum Cancer Professor Chris C Goodnow, Oxford, UK Centre, Melbourne, VIC Professor Carola G Vinuesa Associate Professor L Winteringham and Professor Matthew C Professor Chris C Goodnow, Leukaemia Research Group, The Harry Perkins Institute of Medical Research, Cook Dr Edward M Bertram, Nedlands, WA Molecular and cellular studies of the Associate Professor Guna Dr R Dickins Molecular Medicine adaptive immune response in health Karupiah, Dr Anselm Enders Division, Walter and Eliza Hall Institute of and disease and Dr Katrina Randall Medical Research, Melbourne, VIC Professor C Mackay and Professor F Mackay-Fisson, Monash University, Systems approach to Inflammation Professor Chris C Goodnow, Clayton, VIC Professor J Sprent, and Immunity Emeritus Professor A Basten, Dr S Mr Yogesh Jeelall, Professor Professor R Ulevitch The Scripps Tangye, Dr R Brink and Dr Daniel Christ, Research Institute, La Jolla, CA, US Matthew C Cook, Dr T Dan Garvan Institute of Medical Research, Professor B Beutler University of Texas Andrews and Sydney, NSW Southwestern Medical Center, Dallas, Mr Matthew Field Texas, USA Dr A Aderem and Institute Professor Chris C Goodnow, for Systems Biology, Seattle, WA, US Dr Developing novel deep sequencing G Nolan Department of Microbiology and methods for tracking human Dr Steve WInslade and Dr T Immunology, Stanford University, Palo lymphoma mutations Dan Andrews Alto, CA, US Dr D Talaulikar Canberra Hospital, Framework Data Sets Canberra, ACT Mr A Gilbert Bioplatforms Australia, Professor Chris C Goodnow Sydney, NSW and Dr Michael Dobbie Professor Chris C Goodnow Australian Phenomics Network Project: ES and Dr Ian Parish Professor Jill E Gready cell to Mouse Service Imaging proximal T cell signalling Characterization of natural variation Associate Professor I Smyth Professor K Gaus Centre for Vascular of photosynthetic genes of potato for Department of Biochemistry and Molecular Research, University of New South Wales, breeding improved cultivars with increase Biology Faculty of Medicine, Nursing Sydney, NSW productivity and nutritional benefits and Health Sciences, Monash University, International Potato Center, Clayton, VIC Characterisation of an ENU mutant Dr D Ellis mouse line with a defect in gut peristalsis Lima, Peru Australian Phenomics Network Project: Development of ANU technology for the ENU Variant Collection Professor H Young and Professor J Furness Department of Anatomy and design of variant Rubisco proteins with Professor B Kile Chemical Biology Neuroscience, University of Melbourne, improved catalytic activity Division, Walter and Eliza Hall Institute of Melbourne, VIC Research School of Medical Research, Melbourne, VIC Professor JE Evans Biology, The Australian National University, Professor S Foote Australian School of Canberra, ACT Dr J van Rie and Dr A Advanced Medicine, Faculty of Human Gallé Bayer CropScience, Sciences, Macquarie University, Ghent, Belgium Sydney, NSW
36 The John Curtin School of Medical Research Dr Rebecca Haddock Associate Professor Gavin Associate Professor Guna Role of NOX-2 in obesity-related Huttley and Dr Åsa Pérez- Karupiah and Dr Geeta hypertension Bercoff Chaudhri Associate Professor GG Drummond Understanding the genetic causes of Modulation of the immune response by Department of Pharmacology, Monash virulence in fungal pathogens virus-encoded cytokine homologs University, Melbourne, VIC Professor W Meyer Molecular Mycology Professor M Buller St Louis University, Role of immune cell derived NGF Research Laboratory, Centre for Infectious St Louis, MO, US Professor A Alcami in hypertension Disease and Microbiology, Westmead Centro de Biología Molecular Severo Dr A Vinh Department of Pharmacology, Millennium Institute, Westmead Hospital, Ochoa, Madrid, Spain Monash University, Melbourne, VIC Sydney Medical School Westmead, The Induction of long-lived antiviral University of Sydney, Westmead, NSW humoral immunity Professor H Nevalainen and Professor Associate Professor Gavin I Paulsen Department of Chemistry Dr T Newsome School of Molecular Huttley and Biomolecular Sciences, Macquarie Bioscience, University of Sydney, Sydney, University, Sydney, NSW NSW Professor R Brink Garvan Institute Reconstruction of coral phylogeny for Medical Research, Sydney, NSW Dr S Forêt Research School of Biological Dr Andrew James Actin-based motility as a virulence Sciences, The Australian National mechanism and potential as an University, Canberra, ACT Multimodal multifocal neuroimaging of antiviral target human visual cortex Mathematical models of Dr T Newsome School of Molecular sequence divergence Dr S Vanni Clinical Neurosciences, Bioscience, University of Sydney, Dr C Burden Mathematical Sciences Neurology; University of Helsinki and Sydney, NSW Helsinki University Hospital, Institute, The Australian National University, Pathophysiological significance of reverse Helsinki, Finland Canberra, ACT signalling through membrane TNF Retinotopy constrained EEG source Annotation of novel genomes; and, Professor A Alcami Centro de Biología reconstruction without fMRI identifying genes undergoing Molecular Severo Ochoa, Madrid, Spain natural selection Dr SA Inverso Wyss Institute, Harvard University, Boston, USA Dr A Papanicolaou CSIRO Ecosystem Professor Trevor D Lamb Sciences, Canberra, ACT Evolution of vertebrate photoreceptors Development of a software library for Mr Yogesh Jeelall genomic biology; numerous other projects Professor D Hunt, Associate Omenn-like syndrome associated with related to the evolutionary dynamics of Professor N Hart, Dr WIL Davies and a functional reversion due to a somatic sequence divergence Professor SP Collin School of Animal second-site mutation in Biology, University of Western Australia, Professor R Knight Department of CARD11 deficiency Perth, WA Chemistry and Biochemistry, University of Professor S Ehl and Dr S Fuchs Center Colorado, Boulder, CO, USA Responses of human cone for Chronic Immunodeficiency (CCI), photoreceptors measured from Development of Markov-process models University Medical Center and University the electroretinogram to measure the influence of sequence- of Freiburg, Freiburg, Germany neighbourhoods on mutation dynamics Dr O Mahroo Retinal Service, Moorfields Eye Hospital, London, UK Associate Professor VB Yap Department Dr Ben Kaehler of Statistics and Applied Probability, National University of Singapore, Singapore Genetic distance for a general non- stationary Markov Substitution Process Associate Professor VB Yap Department of Statistics and Applied Probability, National University of Singapore, Singapore Lessons from Nature Dr H Trueman CSIRO Ecosystem Sciences, Canberra, ACT
Annual Review 2014 37 Associate Professor Brett Texture discrimination Dr Maxim Nekrasov Lidbury Professor JD Victor Brain and Mind CINDy – Chromosome Interaction Research Institute and Department of Network DYnamics in adipose stem cells Systematic review and meta-analyses as Neurology, Cornell Weill Medical College, Professor P Collas Department of a complementary technique to enhance New York, NY, USA predictions from pattern recognition Biochemistry, Institute of Basic Medical involved in a novel animal Diabetic retinopathy and Sciences, University of Oslo, replacement system macular degeneration Oslo, Norway Professor M Ritkes-Hoitinga and Dr Professor C Nolan and Dr RW Essex The role of Histone variants in formation K Wever SYRCLE, Radboud University ANU Medical School, The Australian of fear memory National University, Canberra, ACT Nijmegen, The Netherlands Dr T Bredy Queensland Brain Institute, Pattern recognition in pathology data and Migraine, epilepsy and stroke The University of Queensland, in vitro validation of diagnostic Professor C Lueck ANU Medical Brisbane, QLD data networks School, The Australian National University, Associate Professor T Badrick Faculty Canberra, ACT Professor Christopher Parish of Health Sciences and Medicine, Bond Role of platelets in tumour metastasis University, Gold Coast, QLD Dr Claudio A Mastronardi Professor B Chong School of Viral diseases and genetics of the Mediators of inflammation Pathology, The University of New South host response Dr J Fernandez-Solari Faculty of Wales, Sydney, NSW Associate Professor M Heise Dentistry, University of Buenos Aires, Studies of immune thrombocytopenia Department of Genetics, University of Buenos Aires City, Argentina and National Professor B Chong School of North Carolina, Chapel Hill, NC, USA Council for Scientific and Technical Pathology, The University of New Metabolomic profiles and clinical Research (CONICET), Argentina South Wales, Sydney, NSW Professor microbiology of ME-CFS P Barrionuevo Medical Research L Khachigian Centre for Vascular Institute (National Academy of Medical Dr Neil McGregor, Associate Research, The University of New South Research – CONICET), Professor P Gooley and C Armstrong Buenos Aires City, Argentina Wales, Sydney, NSW Bio21 Institute and University of Melbourne, Melbourne, VIC Nuclear localisation of heparanase and other proteins Immunology of ME-CFS Dr Claudio A Mastronardi, Professor R Stocker Department of Professor S Marshall Griffith Health Associate Professor Pathology, The University of Sydney, Institute, Griffith University, Mauricio Arcos-Burgos and Sydney, NSW Professor L Khachigian Gold Coast, QLD Dr Gilberto Paz-Filho Centre for Vascular Research, The Biomedical and clinical study of University of New South Wales, Sydney, Neuroinflammation in ME-CFS patients NSW Associate Professor S Rao Caspase-1-deficient mice Dr D Lewis CFS Discovery, Donvale Faculty of Applied Science University of Dr M Zanoni University of Verona, Specialist Medical Centre, Donvale, VIC Canberra, Canberra, ACT Verona, Italy Professor J Licinio and Novel angiogenesis inhibitors Professor M-L Wong South Australian Professor Ted Maddess Health and Medical Research Institute Dr P Karuso Department of Chemistry and Flinders University of South Australia, and Biomolecular Sciences, Macquarie Multifocal visual evoked potentials Adelaide, SA University, Sydney, NSW Dr M Kelso Dr S N Abdullah Raja Isteri Pengiran School of Chemistry, University of Anak Saleha (RIPAS) Hospital, Bandar Wollongong, Wollongong, NSW Seri Begawan, Brunei Dr Claudio A Mastronardi, Islet heparan sulfate and type I diabetes Structure and interactions of the squid Dr Gilberto Paz-Filho, Ms Professor R Rodgers Department of retinal molecule Belinda Whittle and Mr Obstetrics and Gynaecology, University of Professor Y Nagai and Dr M Kito Robert Tuningley Adelaide, Adelaide, SA Professor T Kay Kokushikan University, Tokyo, Japan St Vincent’s Institute, Melbourne, VIC Dried blood spot sampling for the Causes of glaucoma measurement of HbA1c Targeted mistletoe tumour therapy Professor WE Sponsel and Dr M Reilly Ms T Neeman Statistical Consulting Associate Professor L Simson Faculty Department of Biomedical Engineering, Unit, The Australian National University, of Applied Science University of Canberra, University of Texas, San Antonio, Canberra, ACT Canberra, ACT TX, USA
38 The John Curtin School of Medical Research Development of heparan sulfate mimetics Dr Gilberto Paz-Filho Mr Alvin Pratama for type 1 diabetes treatment Studies on leptin deficiency, MicroRNA-146a represses T follicular Professor M von Itzstein Institute for antidepressant-induced obesity, and helper cell accumulation Glycomics, Griffith University, mood disorders Gold Coast, QLD Dr R Casellas Genomics and Immunity Professor M-L Wong and Professor Section, National Institute of Arthritis Development of inhibitors of neutrophil J Licinio South Australian Health and and Musculoskeletal and Skin Diseases, extracellular traps Medical Research Institute, Adelaide, SA National Institutes of Health, Bethesda, Professor M von Itzstein Institute for Congenital leptin deficiency MD, USA Dr A Hutloff Chronic Immune Glycomics, Griffith University, Reactions Group, German Rheumatism Gold Coast, QLD Professor T Delibasi Department of Research Centre Berlin, Berlin, Germany Endocrinology, Hacettepe University, Turkey Dr Hardip Patel Professor Thomas Preiss Adipose tissue biology Effect of placental gene expression on The human Piwi protein Hiwi2 associates Professor S Bornstein and Dr M cord blood during asthma with tRNA-derived piRNAs in Ehrhart- Bornstein University of Dresden, somatic cells Associate Professor V Clifton Dresden, Germany Robinson Research Institute, University of Associate Professor G Hutvagner Pathology testing through dried blood spot Adelaide, Adelaide, SA University of Technology, Sydney, NSW MyHealthTest Pty Ltd, Canberra, ACT Associate Professor C Suter The Physical mapping and assembly of the Victor Chang Cardiac Research Institute, Pogona vitticeps genome Leptin in Alzheimer’s disease Sydney, NSW Professor D Martin Professor A Georges and Associate Dr W (Scoot) Kim, University of New Children’s Hospital Oakland Research Professor J Deakin Institute for Applied South Wales, Sydney, NSW Institute, Oakland, CA, USA Ecology, University of Canberra, The prevalence and roles of Bruce, ACT Dr Jason Potas 5-methylcytosine in Dosage compensation of sex 670 nm light reduces allodynia following eukaryotic transcriptomes chromosomes in snakes spinal cord injury Associate Professor C Suter The Dr P Waters Research School of Biology, Associate Professor L Henderson Victor Chang Cardiac Research Institute, The Australian National University, Anatomy & Histology, School of Medical Sydney, NSW Professor S Clark and Canberra, ACT Dr D O’Meally Institute Sciences, The University of Sydney, Professor J Mattick The Garvan for Applied Ecology, University of Sydney, NSW Institute of Medical Research, Canberra, Canberra, ACT Sydney, NSW New pharmacological agents that isolate Immune genes in the developing tammar individual fibre types in the Sequence diversity in the murine wallaby (Macropus eugenii) peripheral nerve cardiomyocyte miRNA population Associate Professor J Deakin Institute Professor RT Sudo Universidade Associate Professor D Fatkin The for Applied Ecology, University of Federal do Rio de Janeiro, Victor Chang Cardiac Research Institute, Canberra, Canberra, ACT Rio de Janeiro, Brasil Sydney, NSW Exploring the role of microRNA and target Dr Hardip Patel, Dr Dr Jason Potas, Professor processing variability in cardiac hypertrophy Gilberto Paz-Filho, Greg Stuart and Professor Claudio Mastronardi, Mr Professor R Graham The Victor Chang Ted Maddess Cardiac Research Institute, Sydney, NSW Angad Johar, Mr Aaron Functional mapping of the dorsal column Dynamics of ribosome scanning and Chuah and Professor nucleus: A new approach to sensory recycling revealed by steady-state Mauricio Arcos-Burgos pathway evaluation following spinal translation profiling cord injury Whole exome sequencing of endocrine Dr T Beilharz Monash University, disorders: Translational studies in obesity Professor J Morley University of Melbourne, VIC Western Sydney, Campbelltown, NSW, and thyroid disorders. Translational control of the EBV-encoded Dr S Redmond Graduate School of nuclear antigen, EBNA1 Professor M Boguszewski and Biomedical Engineering, The University of Professor C Boguszewski Universidade New South Wales, Sydney, NSW Dr J Tellam Queensland Institute of Federal do Paraná, Department of Medical Research, Brisbane, QLD Pediatrics, Brazil Professor M-L Wong and Professor J Licinio South Australian Health and Medical Research Institute, Adelaide, SA
Annual Review 2014 39 Developmental defects of the Dr Charani Ranasinghe Dr Katrina Randall gastrointestinal tract caused by dysfunction of a RNA binding protein HIV envelop antibody studies DOCK8 in T cells Professor P Tam Children’s Medical Dr R Center Department of Microbiology Dr J Oliaro Peter MacCallum Cancer Research Institute, Sydney, NSW and Immunology, The University of Centre, Melbourne, VIC Melbourne, Melbourne, VIC Exploring the interface between RNA, enzymes and metabolites HIV-1 Pox-viral vaccine vectors Dr Danny Rangasamy in cardiomyocytes Dr D Boyle CSIRO Livestock Industries, Toward repurposing antiviral drugs in the Professor M Hentze European Australian Animal Health Laboratory, treatment of psoriasis Geelong, VIC Molecular Biology Laboratory (EMBL), Professor J-P Molès, Institut national Heidelberg, Germany HIV-1 mucosal vaccines and murine de la santé et de la recherche médicale, The role of miRNAs in the generation of influenza-HIV-1 studies Montpellier, France iPS cells Dr J Stambas Deakin University and Exploring the role of L1 retrotransposon Professor A Nagy and Dr I Rogers CSIRO Animal Health Laboratories, and Rad21 in CRC Cancer Geelong, VIC Lunenfeld-Tanenbaum Research Institute, Dr X Huiling Peter MacCallum Cancer Toronto, ON, Canada Professor TNF family members and immune Centre, Melbourne, VIC J-S Seo Genomic Medicine Institute responses to infection (GMI), Medical Research Center, Seoul Prognostic value of LINE-1 Dr L Sedger School of Medical and National University, Seoul, Korea retrotransposon expression in Molecular Biosciences, The University of Professor J Rasko Gene and Stem Cell breast cancer Technology, Sydney, NSW Therapy Program, Centenary Institute, Professor JE Dahlstrom Anatomical Camperdown, NSW Professor A Heck Mucosal HIV, TB vaccines and Pathology, ACT Pathology, Canberra Biomolecular Mass Spectrometry and CD8 T-cell avidity Hospital and ANU Medical School, The Proteomics Group, Bijvoet Center for Professor A Ramsay Gene Therapy Australian National University, Biomolecular Research and Utrecht Program, Louisiana Vaccine Centre, Canberra, ACT Institute for Pharmaceutical Sciences, Louisiana State University Health Sciences Analysis of epigenetic factors in mouse Utrecht University, Utrecht, The Centre, New Orleans, LA, USA embryonic neural stem cells exposed to Netherlands Professor S Grimmond hyperglycemia and Associate Professor C Wells Human HIV-specific T cell immunity & T cell Institute for Molecular Bioscience, The avidity studies Professor ST Dheen Department University of Queensland, Brisbane, QLD Professor A Kelleher Immunovirology of Anatomy, National University of Singapore, Singapore Post-transcriptional control of gene and Pathogenesis Program NCHECR, The expression in inflammation University of New South Wales, Sydney Insertional mutagenesis system to identify NSW and St Vincent’s Centre for Applied epigenetic factors that control embryonic Professor A Ostareck- Medical Research, Sydney, NSW stem cells differentiation Lederer and PD Dr D Ostareck University Hospital Aachen, HIV/SIV macaque vaccine studies Dr N Lenka National Centre for Cell RWTH Aachen University, Professor S Kent and Dr R De Rose Science, Pune University Campus, Aachen, Germany Department of Microbiology and Ganeshkhind, Pune, India Immunology, The University of Melbourne, Melbourne, VIC Professor Jan Provis Dr Daniel Ryan Mucosal vaccine strategies Structural and functional analysis of a Modelling and managing retinopathy against Chlamydia of prematurity cancer-linked co-regulator complex Professor K Beagley Institute of Health Professor J Mackay School of Molecular Professor T Chan-Ling University of and Biomedical Innovation, Queensland Biosciences, University of Sydney, Sydney, Sydney, NSW University of Technology, Brisbane, QLD Sydney, NSW Evaluation of a murine HIV challenge model Professor Jan Provis and Dr Acetylation of histone H3 at lysine 64 Professor A Suhrbier QIMR Berghofer regulates nucleosome dynamics and Riccardo Natoli Medical Research Institute, Brisbane, QLD facilitates transcription Differential effects of 670 and 830nm red Dr R Schneider Department of Functional near infrared irradiation therapy Genomics, Institut de Génétique et de Professor S Dunlop and Associate Biologie Moléculaire et Cellulaire (IGBMC), Professor L Fitzgerald School of Animal CNRS UMR, Strasbourg, France Biology, University of Western Australia, Perth, WA
40 The John Curtin School of Medical Research Dr Charmaine J Simeonovic Associate Professor Dr Krisztina Valter Heparan sulfate expression in human Christian Stricker Slow-release treatment options in drug pancreas, isolated human islets and Short-term dynamics in small networks delivery to the retina islet transplants Dr M McDonnell Institute of Professor S Bisti University of L’Aquila, Professor S Bornstein and Dr B Telecommunications Research, University L’Aquila, Italy Ludwig University Clinic Carl-Gustav- of South Australia, Adelaide, SA The effects of VCP treatment in the Carus, Technical University, degenerative retina Dresden, Germany Professor Greg J Stuart Professor GJ Kotwal Kotwal Bioconsulting Heparan sulfate and heparanase and St Kitts Medical School, WI, USA expression in human pancreas Action potential initiation and interaction Professor GJ Arason University of Iceland, Clinical Associate Professor JD with inhibitory synaptic events Reykjavik, Iceland Wilson Department of Endocrinology, Professor M Häusser The Wolfson Muller cell reactive gliosis and its control, Canberra Hospital, Canberra, ACT Institute for Biomedical Research, University using in vivo and in vitro models College, London, UK Dr M Madigan Save Sight Institute, Dr Charmaine J Simeonovic, Dendritic activity and neuronal output University of Sydney, Sydney, NSW and Ms S Dhounchak and during sensory perception Department of Optometry, University of NSW, Professor Christopher R Dr L Palmer The Florey Institute of Sydney, NSW Neuroscience and Mental Health, Parish 670 nm red light treatment in University of Melbourne, retinal degenerations Loss of islet heparan sulfate in T2D in db/ Melbourne, VIC Professor JT Eells University of Wisconsin, db mice Milwaukee, WI, USA Professor T Biden and Dr R Laybutt Professor David Tremethick The effects on 670 nm light in retinal damage Garvan Institute of Medical Research, The role of histone variants in modulating Dr R Essex ANU Medical School, The Sydney, NSW chromatin fibre dynamics Australian National University, Canberra, ACT Dr K Luger Department of Biochemistry Oxygen-induced retinopathy and 670 nm light Dr Charmaine J Simeonovic and Molecular Biology, Colorado State and Professor Christopher University, Fort Collins, CO, USA Professor JE Dahlstrom Anatomical Pathology, ACT Pathology, Canberra Hospital The role of histone variants during R Parish and ANU Medical School, The Australian spermatogenesis Protection of human islet beta cells by National University, Canberra, ACT Dr A heparin and HS-mimetics Dr J Bowles Institute for Molecular Kent, Dr R Essex and Dr A-L Mohamed Bioscience, University of Queensland, ANU Medical School, The Australian National Professor T Kay, Dr H Thomas and Dr Brisbane, QLD University, Canberra, ACT and ACT Health, T Loudovaris Immunology and Diabetes The Canberra Hospital, Canberra, ACT Unit, St Vincent’s Institute, Melbourne, VIC Chromatin function in differentiation Professor A Pugliese Diabetes Research and cancer Institute, Department of Medicine, Professor SA Grigoryev Department Division of Diabetes, Endocrinology of Biochemistry and Molecular Biology, and Metabolism, and Department of Milton S Hershey Medical Centre, Penn Microbiology and Immunology, University State University College of Medicine, of Miami Miller School of Medicine, Miami, Hershey, PA, USA FL, USA Regulation of promoter architecture: global changes in H2A.Z nucleosomes Dr Zan-Min Song during differentiation and cancer Non-enteric phenotype of Dr JH Dennis Department of Biological Hirschsprung’s disease Science, The Florida State University, Tallahassee, FL, USA Associate Professor D Croaker Canberra Hospital, Canberra, ACT Post translational modifications of histone variants and their role in transcription and Surgical intervention to rescue pre mRNA splicing Hirschsprung’s disease in a rat model Professor Dr U-M Bauer Institute for Professor H Young and Professor J Molecular Biology and Tumor Research, Furness Department of Anatomy and Philipps-University Marburg, Germany Neuroscience, University of Melbourne, Melbourne, VIC
Annual Review 2014 41 Professor Carola G Vinuesa Professor Carola G Vinuesa, Professor Ian G Young Ontogenic relationship between Tregs and Professor Matthew Cook, Dr Role of IL-3 receptor in follicular regulatory T cells Dan Andrews, Mr Matthew myeloid leukaemia Professor A Liston, University of Leuven, Field and Dr Anselm Enders Professor YZ Chen and Dr Y Wu Fujian Leuven, Belgium Medical University, Fuzhou, China Identification of novel and rare mutations in B cell signatures in SLE autoimmunity Cytokine receptors Professor V Pascual Center for Dr S Alexander The Children’s Hospital at Dr J Murphy Molecular Medicine Division, Inflammation and Autoimmune Diseases and Westmead, Westmead, NSW Associate Walter and Eliza Hall Institute of Medical Center for Personalized Medicine, Baylor Professor D Fulcher Department of Research, Melbourne, VIC Institute, Dallas, TX, USA Immunopathology, The Children’s Hospital Role of cytokines in allergic inflammation at Westmead, Westmead, NSW Professor Role of Dopamine in antibody responses Professor PS Foster School of Biomedical R Kitching Faculty of Medicine, Nursing Dr C Doglioni, Department of Pathology, San Sciences and Pharmacy, University of & Health Sciences, Monash University, Raffaele Hospital, Milan, Italy Newcastle, Newcastle, NSW Melbourne, VIC Professor N Shen Jiao Single cell investigation of B cell differentiation Tong University, Shanghai, China Professor and switching E Morand School of Clinical Sciences, Dr J Polo Department of Anatomy and Monash Health and Faculty of Medicine, Developmental Biology, Monash University, Nursing & Health Sciences, Monash Melbourne, VIC Dr K-M Toellner Institute of University, Melbourne, VIC Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK MicroRna transcription and CRISPR/Cas9 DNA editing Dr R Casellas Genomics and Immunity Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA Insights from Roquin crystal structure into miRNA/mRNA regulation Dr J Babon The Walter and Eliza Hall Institute for Medical Research, Melbourne, VIC
42 The John Curtin School of Medical Research AUSTRALIAN PHENOMICS FACILITY COLLABORATIONS
Systems Approach to Asian Mouse Mutagenesis Mutagenetix Immunity and Inflammation and Resource Association- A database of mutations and phenotypes A project in its second 5 year funding Asian Mouse Phenotyping induced by ENU cycle with the overall goal to identify Consortium Professor B Beutler University of Texas and characterise novel regulators of the Southwestern Medical Center, Dallas, immune response to NIAID The Asian Mouse Mutagenesis and TX, USA Priority Pathogens Resource Association (AMMRA) is a collaborative group for the development, Professor B Beutler University of Texas archiving/distribution, coordination of Framework Data Sets Southwestern Medical Center, Dallas, TX, phenotyping and informatics of mutant Mr A Gilbert Bioplatforms Australia, USA Professor R Ulevitch The Scripps mice in Asia. Research Institute, La Jolla, CA, USA Sydney, NSW Professor A Aderem Department of Professor X Gao (President) National Immunology, University of Washington, Resource Center of Mutant Mice Seattle, WA, USA and Seattle Biomed, (NRCMM), Nanjing University, China Seattle, WA, USA Professor G Nolan Stanford University Palo Alto, CA, USA Korean Mouse Phenotying Consortium International Mouse Professor JK Seong Seoul National Phenotyping Consortium University, Seoul, Korea Dr KT Nam The goal of the International Mouse Yonsei University, Seoul, Korea Phenotyping Consortium (IMPC) is to discover functional insight for every Hunter Genetics/ Rare gene by generating and systematically phenotyping 20,000 knockout mouse Voices strains. The APN missense mutation Hunter Genetics have used the exome library is linked by gene to the IMPC and discovery pipeline to identify rare variants. MGI JAX databases so that researchers Dr T Dudding, Dr B Kamien, Dr H from around the world can easily access Goel and Dr A Ronan Hunter Genetics, the APN resource. Waratah, NSW Professor S Brown (Chair), Harwell MRC, Harwell Science and Innovation Campus Oxfordshire, UK Dementia Collaborative Research Centre Associate Professor N Cherbuin Research School of Population Health, The Australian National University, Canberra, ACT, ANU
Annual Review 2014 43 44 The John Curtin School of Medical Research Staff and Student Lists
Department of Genome Biology
Department of Immunology
Eccles Institute of Neuroscience
Department of Molecular Bioscience
Department of Pathogens and Immunity
Australian Phenomics Facility
School Administration
School Services
The ACRF Biomolecular Resource Facility
Genome Discovery Unit
Imaging and Cytometry Facility
Students
Annual Review 2014 45 Genome Biology
Professor and Head of Computational and Genome Diversity and Department Conceptual Biology Group Health Group Tremethick DJ, BSc(Hons), (USyd), Professor and Leader Professor and Leader PhD (MQ) Gready JE, BSc(Hons), Easteal S, BSc(Hons) (St Andrews), Departmental Administrator PhD (USyd), FRACI MBA, PhD (Griffith) Stenhouse J, BA Senior Research Officers Postdoctoral Fellow Cummins PL, BSc(Hons), PhD (USyd) Das D, BSc(Hons) (Presidency College, Chromatin and Kannappan B, BSc (Madras), MSc, Kolkata), MSc (Madurai Kamaraj), PhD Transcriptional Regulation PhD (Pune) (JNCASR, Bangalore) Group Matthews PR, BSc(Hons), PhD (ANU) Senior Technical Officer Tan X, BSc (Shandong), MSc (China Professor and Leader Research Officers Pharmaceutical) Tremethick DJ, BSc(Hons), (USyd), Kane H, PhD (part-time) PhD (MQ) Postdoctoral Fellows Research Fellow Poire R (from April) Soboleva T, MSc (MSU), PhD (MSU) Vassilieva T, MSc (Novosibirsk) Postdoctoral Fellows Wallace MJ. BSc (Wollongong) (until Domaschenz RM, BSc(Hons) (Adel), PhD January) (Cambridge) (from February) (casual) Research Assistants Nekrasov M, PhD (Heidelberg) Delbridge M (part-time) Ryan DP, BSc(Hons) (USyd), PhD Howles P, BA (USyd), BSc (Adel), Visiting Fellows BSc(Hons), PhD (part-time) Cook AJL, BMedSci(Hons) (USyd), Mani-George A, BSc, (Mahatma Gandhi, PhD (USyd) India), MSc (Bharathiar, India) Domaschenz RM, BSc(Hons) (Adel), PhD Miraghazadeh B (from April) (Cambridge) (from February) Visiting Fellows Hapel A (until September) Armarego W, PhD, DSc (ULond), Parker B, BSc (UQ), MBBS (UQ), PhD FRSC, FRACI (USyd) (from April) Shannon MF, BSc(Hons), PhD (National Computational Genomics University of Ireland) Group Westman B, BSc(Hons) (USyd), PhD Associate Professor and Leader Huttley GA, BSc(Hons) (MQ), PhD (UC Riverside) Postdoctoral Fellows Kaehler B, BSc (UNSW), BEng(Hons) UNSW, MQuantitative Finance (UTS), PhD Pérez-Bercoff Å, PhD (Dublin) Visiting Scholar Zhu Y
46 The John Curtin School of Medical Research National Center for RNA Biology Group Translational Genomics Indigenous Genomics (from Professor and Leader Group February) Preiss T, Dipl Chem (Philipps University Associate Professor and Leader Professor and Director Marburg Germany), PhD (Newcastle upon Arcos-Burgos M, MD, PhD (University of Tyne), Habil (Heidelberg) Easteal S, BSc(Hons) (St Andrews), Cauca, Colombia) MBA, PhD (Griffith) Research Fellows Research Fellows Manager Clancy JL, BSc(Hons) (UNSW), Lidbury BA, BSc(Hons) (Newcastle), PhD PhD (UNSW) Dobbie M, PhD (from September) (from February) Postdoctoral Fellows Mastronardi CA, PhD (University of Research Officer Beveridge N, (UNewcastle) (until June) Buenos Aires, Argentina) (from February) Brown K, PhD (from September) Duan G, PhD (from March) Paz-Filho G, MD (Universidade Federal do Research Assistants Paraná, Brazil) (from February) Kurscheid S, PhD (from December) Pryce K, BAppSci (UHAN, Nijmegen), Liao Y, PhD (UC Davis) Research Assistant BTech (Gilde College, Venlo) Cai Y, BMed Patel H, BPharm, MBiotech, PhD Visiting Fellow (Bejing Medical University, China) Senior Technical Officer Kowal E, MBBS (UMelb), BA (UMelb), Visiting Fellows PhD (UMelb) (from June) Pagler E, BSc (Santo Tomas) Badrick T, BAppSci (QIT), BSc (UQ), BA Visiting Fellows (UQ), MLit (UQ), MBA (UQ), PhD (QUT), Archer SK, BSc(Hons), PhD (from PhD (UQ) September) Cummins T, BSc(Hons) (Adel), PhD (UQ) Serra M, BA (Tarkio), PhD (Ohio U) (from August) (February – May) Richardson AM, BA(Hons) (Well), Shankar R (until July) MStats, PhD Visiting Scholar Shang GF, Master of Medical Immunology (Tongji Medical University, China) Silva Lara M-F, BSc, MSc (from September) School Visitor (Statistical Consulting Unit, ANU) Neeman T, BA (Harvard), MA, PhD (Virginia)
Departmental Visiting Fellows Barlin G, PhD, DSc (USyd), FRACI Cox G, BSc, PhD (UMelb), FAA Denborough M, MD, ChB (Cape Town), MD (UMelb), DPhil (Oxon), DSc (UMelb), FRCP Morrison JE, BSc (USyd), MSc (UQ), DPhil (Oxon), DSc
Annual Review 2014 47 Immunology
Professor and Head of Cancer and Vascular Diabetes/Transplantation Department Biology Group Immunobiology Laboratory Goodnow CC, BSc(Vet) (USyd), Professor and Leader Fellow and Laboratory Leader BVSc(Hons) (USyd), PhD (USyd), FAA, Parish CR, BAgrSc (UMelb), PhD (UMelb) Simeonovic CJ, BSc(Hons), PhD FRS, NAS Departmental Administrator Research Fellow Postdoctoral Fellow Quah B, BSc, PhD Choong FJ, BBioTech(Hons), PhD Weil ETF Postdoctoral Fellow Visiting Fellows Coupland L, BSc(Hons), PhD, RN McCullagh P, MBBS (UMelb), DPhil (Oxon), MRCP (Lond), MD (UMelb) Visiting Fellows Wilson JD, BSc(Hons), MBBCh, Chong G, MBBS (Hons), BMedSc BAO(Hons), MD (Queens, Belfast), MRCP (Monash) FRACS, FRCS (C) FRCS (E), (UK), FRACP Diplomate, American Board of Surgery (USA) Technical Officers Cooper PD, BSc (Hons) (ULond), PhD Brown D, AssDipAppPath (CIT) (casual) (ULond), DSc (ULond) Hamilton P, Certificate II (AnimalT ech) Freeman C, BSc(Hons) (Adel), PhD (Adel) (CIT) (part-time) Hindmarsh EJ, BSc(Hons) (USyd), PhD Popp SK, BSc, AssDipAppSci (Biol) Li RW, MD (China Medical University), (CIT) (part-time) PhD (Southern Cross) Visiting Scholar Price J, BSc(Hons) (UMelb), PhD (UMelb) Hayashi K (until February) Rao S, BSc(Hons) (Keele), PhD (Kings College Lond) Immunogenomics Group Staykova M, PhD (USofia) Professor and Laboratory Head Warren HS, BSc(Hons), PhD (UQ) Goodnow CC, BVSc(Hons) (USyd), Wu Z, MSc (UNSW), BM (Zhongshan BScVet(Hons) (USyd), PhD (USyd), FAA, Medical), PhD (from May) FRS, NAS Xin MY, BMed (Shandong University) Laboratory Manager (until June) Townsend M, PathTech Cert (TAFE), Zhang DH, BMed (2nd Military Medical AssDipAppPath (Bruce TAFE) University, PR China) Senior Technical Officer Bioinformatics Laboratory Bezos A, BSc (USyd), MSc (USyd) Bioinformatics Fellow Technical Officer Andrews TD, BSc(Hons), PhD Browne A, BA (ANU), Dip Ed (UNE) (part-time) Bioinformaticians School Visitor Cho V, BSc (Auck), PhD Wang J, MSc (UNSW) Field M, BSc (Biol)/BSc (Computer Sci) (UBC) Editorial/Administrative Assistant Parish B, BSc (Madras), BSc, MSc, GradDipCompStudies (UC) (part-time)
48 The John Curtin School of Medical Research Immune Tolerance and Ramaciotti Immunization Molecular Mucosal Vaccine Signalling Laboratory Genomics Group Immunology Group Professor and Laboratory Leader Senior Research Fellow Fellow and Leader Goodnow CC, BVSc (USyd), and Leader Ranasinghe C, BSc (Uni Rouen, France), BScVet(Hons) (USyd), PhD (USyd), FAA, Enders A, MD, PhD (Freiburg) MPhil (Uni Colombo), PhD (UWA) FRS, NAS Research Technician Resarch Fellow Research Fellow Jackson R, BSc (Hons) (Monash), Barthel N, DipBiol (Freie Univ, Berlin) Bertram E, BSc(Hons) (Adel), PhD (Adel) PhD (Edin) CJ Martin Fellows Infection and Immunity Adjunct Fellow Parish IA, BSc(Hons), PhD (WEHI) Group Sedger L, BAppSci(Hons) (UTS), PhD Reed JH, BSc(Hons) (Flinders), PhD Visiting Fellows (Flinders) (until November) Associate Professor and Leader Mullbacher A, BSc, MSc (Auck), PhD Research Fellows Karupiah G, BSc(Hons), MSc (Malaya), PhD Stambas J, BSc(Hons) (UMelb), Daley S, BVSc (UQ), DPhil (Oxon) PhD (UMelb) Senior Technical Officer Horikawa K, MD (Chiba), PhD (Tokyo) Wijesundara D, BSc (Hons), PhD Eldi P, MBBS (India), MSc (UQ) (part-time) Srivastava M, MSc (Rewa), PhD (from March) (from January) Visiting Fellows Visiting Technical Officers Research Technicians Chaudhri G, BSc(Hons), PhD Buchanan A, BHealthSci (UC) Balakishnan B, BSc(Hons) Newsome TP, BSc(Hons) (UMelb), PhD Ravichandran J, BSc (India), BSc(Hons) (Inst Molecular Pathology, Vienna) (UMelb) (part-time) Howard D, BSc (until July) Kaya MS, BSc (from February) Worley M, BSc Law H, BSc Visiting Scholar Miosge L, BSc(Hons), PhD El Eryani G, BSc Sontani Y, BSc(Hons) (Murdoch), PhD Laboratory Assistant Translational Research Unit Kanazawa Y (casual) (joint with The Canberra Hospital) Visiting Fellows Randall K, MB (UNSW), BS (UNSW), BSc Professor and Leader (UNSW), FRACP, FRCPA, PhD Cook M, MB, BS (USyd), FRACP, FRCPA, Reed JH, BSc (Hons) (Flinders), PhD PhD (USyd), FFSc(RCPA) (Flinders) (from November) Postdoctoral Fellow Wilson A, BSc(Hons) (UC), RN Sweet R, BSc (UCLA), MSc (Yale), MPhil (Yale), PhD (Yale) (from September) Research Assistants Chand R, BSc(Hons) (UMelb) Lam W, BSc (Adel) Wilson A, BSc(Hons) (UC), RN (part-time)
Annual Review 2014 49 Eccles Institute of Neuroscience
Professor and Head Development of Visual Human Neuroimaging Stuart GJ, BSc(Hons) (Monash), PhD Diagnostics of Eye Group (ANU), FAA Disease Group Associate Professor and Leader Departmental Administrator Professor and Leader James AC, BSc(Hons)(Adelaide), Ursino D Maddess T, BSc(Hons) (UBC), PhD (ANU) PhD (ANU) Senior Technical Officer Research Fellows Neural Coding Group Rodda GR, PTC Barbosa M, BSc, MSc, PhD (São Paulo) Associate Professor and Leader Carle C, BSc(Hons), PhD Arabzadeh E, MD, PhD Blood Vessel Group Sabeti F, BOptometry(Hons), Professor and Leader GradCertOcuThera, PhD (until August) Postdoctoral Fellow Hill CE, BSc(Hons), PhD, DSc (UMelb) Centre Managers Adibi M, BSc (Isfahan University of Technology, Iran), MSc (Iran University of Rohan E (from July) Postdoctoral Fellow Science and Technology, Tehran), Howitt L, BSc (USyd), PhD (UNSW) Curran B, BSc (ANU) (until August) PhD (UNSW) (until April) Technical Assistants Kheradpezhouh E, MD (Shiraz, Iran), PhD (Adelaide) (from February) Chia RH (until February) (casual) Neuroimmunology & Perera T (until February) (casual) Research Assistant Cardiovascular Dysfunction Seah R (from November) (casual) Sizemova A Laboratory Visiting Fellows Leader Neuronal Network Group Bell A (from July) Haddock RE, BSc (Wollongong), Farshid E Associate Professor and Leader BSc(Hons), PhD (ANU) Hughes A Stricker C, MD (Zurich), PhD (Bern) Postdoctoral Fellow Mallikarjunan R Research Fellow Morton S, BSc(Hons) (Massey), PhD Cowan AI, BSc(Hons), PhD (ANU) (ANU) (July - December) Stronks C (from December) Vidovic M Neuronal Signalling Group Cerebral Cortex Group Xiang F (until July) Professor and Leader Professor and Leader Adjunct Positions Stuart GJ, BSc (Hons) (Monash), PhD Bekkers JM, BSc(Hons) (Griffith), MSc Ibbotson M, BSc, PhD (ANU), FAA (Manchester), PhD (Cambridge) Penfold P Postdoctoral Fellows Sarac Ö (from February) Choy J, BSc (UMS), PhD (until July) University Fellow and Suzuki N, BSc (Tsukuba), MMedSci Emeritus Professor (Tsukuba), PhD (Tokyo) Levick W Tantirigama M, BSc(Hons) (Otago), PhD (Otago) (from February) Research Assistant Tang S-M (until February)
50 The John Curtin School of Medical Research Neurophotonics Laboratory Synaptic Mechanisms Neural Control Systems Leader Laboratory Group Daria V, PhD (Osaka University) Billups B, BSc(Hons) (UCL), MSc Leader (Birmingham), MA (Cambridge), PhD Potas JR, BMedSc(Hons) (USyd), Postdoctoral Fellow (UCL) (from September) PhD (USyd) Choy J, BSc (UMS), PhD (ANU) (from August) Retinal Cell Damage and Visual Neuroscience Group Research Assistants Repair Group Professor and Leader Sane S (until August) Professor and Leader Lamb TD, BE (UMelb), ScD (Cambridge), Go M (until September) Valter K, MD, PhD, GradCert HE FRS, FAA Gautiam V (from September) Research and Body Donation University Fellow and Co-ordinator Emeritus Professor Brain Development Natoli R, BSc(Hons) (USyd), PhD (ANU) Curtis DR, AC, MBBS (UMelb), PhD, Laboratory FRACP, FAA, FRS Leader Retinal Development and Song Z-M, MMSc (Jiamusi), Aging Group PhD (Flinders) Professor and Leader Neuronal Signalling Provis J, BSc(Hons) (UNSW), PhD (UNSW) Laboratory Postdoctoral Fellows Professor and Leader Bhat P, MBBS, FRACP, Stuart GJ, BSc(Hons) (Monash), PhD PhD (from February) (ANU), FAA Howitt L, BSc (USyd), PhD (UNSW) Postdoctoral Fellows (May - November) Bock T, PhD (ANU) (March - June) Rutar M, BMedSc(Hons), PhD (ANU) Ikeda K, BA (UC Boulder), PhD (ANU) Research and Body Donation Jones S, PhD (ANU) (from April) Co-ordinator Keshavarzi S (until February) Natoli R, BSc(Hons) (USyd), PhD (ANU) Visiting Fellow Madigan M
Annual Review 2014 51 Molecular Bioscience
Professor and Head of Biomolecular Interactions Cancer Metabolism and Department Group Genetics Group Dulhunty AF, BSc (USyd), PhD, Senior Research Fellow and Fellow and Leader DSc (UNSW) Leader Blackburn A, BSc(Hons) (UNSW), PhD Department Administrator Casarotto MG, BSc(Hons) (UMelb), Laboratory Technician Ursino D PhD (UMelb) Postdoctoral Fellow Rooke M, BMedSci (Pharm Sci) (CSU) Joseph S, BSc(Hons) (USyd), PhD (USyd) (from August) Cytokine Molecular Biology Technical Officer and Signalling Group Aditya S, BBiotech(Hons) (ANU) Professor and Leader Visiting Fellows Young IG, MSc (UMelb), PhD Fan J, BSc (Fudan), MSc (Fudan), Postdoctoral Fellow PhD (Auck) Abdus F, BSc(Hons) (Bangladesh), MSc Lim PS, BMedSci, PhD (UWSyd), PhD Zafar A, PhD Visiting Fellows Visitor Chen J, BSc, (China), MMed (China), PhD (Flinders) Rosenberg M, PhD Murphy J, BSc, PhD Visiting Scholar Yong W, MMed (China), MD (China) Technical Officers Dai J, BSc, MBiotech Ewens C Wen B, MB (China), MSc (China), PhD
52 The John Curtin School of Medical Research Epigenetics and Genome Muscle Research Group Stem Cells and Gene Stability Group Professor and Leader Targeting Group Fellow and Leader Dulhunty AF, BSc (USyd), PhD, Professor and Leader Rangasamy D, MSc, MTech (India), DSc (UNSW) Matthaei KI, BSc(Hons) (UNSW), PhD PhD (UK) Senior Research Advisor Visiting Fellows Gallant E, PhD (Minnesota) Molecular Genetics Group Barharvand H Postdoctoral Fellows Frese M, BSc (Osnabrück), PhD (Freiburg) Professor and Leader Karunasekara YA, MD (USSR), PhD Board PG, BSc(Hons), PhD (UNE) (until April) Postdoctoral Fellow Visiting Fellow Theodoratos A, BSc(Hons) (USyd) PhD Karunasekara YA, MD (USSR), PhD (from April) Visiting Fellows Salvage S, PhD (Oxford) Baker R, BSc(Hons)(UNSW), PhD Tierney L, BSc, MSc (Otago), PhD Coggan M Senior Technical Officer Dahlstrom J, MBBS(Hons), FPAC, PhD, FRCPA, FFOP, FFSc, GradCertEdSt Pace S, BSc (UTS) (HigherEd), SFHEA Laboratory Technicians Hayes MT, BSc (USyd), MSc (USyd), Stivala J DipEd (Tert) (UNE), PhD (QUT) (until October) Thekkedam C, BScBioTech(Hons) (Wollongong) Lee E, BSc(Hons), PhD Liu D, PhD (USyd) (from March) Ramshaw IA, MSc (Brunel), PhD Shield A, BBiotech(Hons) (Flinders), PhD (Flinders) Visiting Scholar Takemura K, PhD Laboratory Technicians Cappello J, BSc (UC), AD AppSciAnSci (CIT) Tummala P, BSc (Nagarjuna U) MSc (MSU), PhD (OU)
Annual Review 2014 53 Pathogens and Immunity
Professor and Head of Humoral Immunity and Inflammatory T Cell Department Autoimmunity Group Responses Group (from Vinuesa CG, LMS(MBBS) (Madrid), Elizabeth Blackburn NHMRC July) DRCOG (Lond), MSc, PhD (Birmingham) Research Fellow Research Fellow and Leader Departmental Administrator Vinuesa CG, LMS(MBBS) (Madrid), Breustle A, PhD (from July) Morales D DRCOG (Lond), MSc, PhD (Birmingham) CJ Martin Fellow Malaria and Infectious Ellyard J, BAs, BSc(Hons), PhD Disease Group (from Post-doctoral Fellows October) Athanasopoulos V, BSc (Hons), Professor and Leader PhD (UMelb) Foote S, MBBS, DSc, FFSc (RCPA), Duan T, MBBS (Nanjing), PhD FAHMS, FTSE (until March) Research Fellow Sweet R, BSc (UCLA), MSc (Yale), MPhil (Yale), PhD (Yale) (until August) McMorran B, BSc(Hons), PhD (Otago) (from December) Visiting Fellows Good M, AO, BSc, MBBS, PhD, MD, DSc Malaria Immunology Group Walter G, BA (Cantab), MBChB (Edinburgh), MRCP (UK), MD Group Leader Cockburn I, MBiochem (Oxon), PhD (Edin) Laboratory Technical Staff Capello J (from February) Postdoctoral Fellow Williams N Dups J, BVSc (UQ), PhD (UMelb) (from October) Research Assistant Laboratory Technician Lee SK, MBioTech (Flinders) (April - October) Cai Y, BMed (Beijing Med) (from September)
54 The John Curtin School of Medical Research Australian Phenomics Facility and animal services
Director Information Technology Technicians Winslade SL, BA(Hons) (UNE), PhD (UNE) IT Manager Allsop I, Cert III Animal Tech (CIT) Aquino W, BAniSci (UWS) Head of Animal Services Wu P, BSc(Hons), BCompSci (Canada) Arthur M Fowler S, BSc, BVMS (Murdoch) IT Officers Barker A Head of International Programs Hongyu M, BCompSci (China), Bertram E, BSc(Hons) (Adel), PhD (Adel) MSwE (Singapore) Boljun M Burke J Scientific Business Manager Jiang M, BCompSci (China), MComp (ANU), MIS (ANU), MBA Candidate Burt K (from June) Dobbie MS, BAppSc (UTS), MSc (USyd), BIS (ANU) PhD (Lond) Bush T Tan J, BCompSci (UA), MComp (UA) Liaison Officer Caston K (from June) Quinn G Hewitt L, BMedSci (UC) Chau K, Dip Animal Tech (CIT) (until Shaw F December) Departmental Administrator Cook A O’Keefe R Genomics Corby R (from June) Head of Genomics Research Cover G Scientific Programs Whittle B, BSc(Hons) Facchin D (from June) Scientific Programs Manager Genomics Coordinators Fowlie C Balakishnan B, BSc(Hons) Mann D, BSc(Hons) (until October) Haas P Scientific Project Coordinators Stefanovic T, BMedSc(Hons) Hamilton R Kofler J, DipAnTech (CIT), BSc (from October) Hartley S Morris L, BSc(Hons) (Lond), MSc(Res) Zhang Y, BSc, MSc (China) Jarvis L (Edin), PhD (Edin) Genomics Technical Officers Kaya MS, BSc (UNewcastle) Osborne A, BAnimalSci (JCU) (from July) Armstrong M Lin Q Tunningley R, BMedSci Fitzgerald L, AssocDip Animal Sci, Cert IV Lind F (until December) Scientific Project Technicians Vet Nursing (CIT) Lockley J Kan W, BBioMedSc (Hons) (Monash) Gao J, BSc (China), MBiotech(Hons) Lorenzi L Lorenzo A, BSc Biol (RP) Liang R, BSc, MSc (China) Milne R (from June) Mei Y (from April) Liu M, BSc, MSc (China) McGowan A Nasreen M (from March) Palkova A, BBus (QUT), BSc(Hons) (UQ) McWilliam D Patel V Pobjie A, DipAniTech (CIT) Australian Phenome Bank Sakthivel G, BMedSci(Hons) Portway C Sayeed S, BSc, MSc (Bangladesh), PhD (UK) Phenome Bank Curator Prewett B Schoning J, BBiotech(Hons) Read SH, BSc(Hons) (Adel), PhD (Adel) Sibley B Shang G (from March) Cryopreservation and IVF Sparrow M Coordinator Spencer C du Boulay C, Cert IV Vet Nursing (CIT), Animal Services Steen E Dip AppSci (CIT) Animal Services Managers Talbot S, Dip AppSci (Animal Tech) (CIT) IVF and Cryopreservation Bowditch K Vithanage U Technician Clydesdale M Watson D Thomsen N, BSc(Hons) (UQ) Animal Services Coordinators Young S Quarantine Coordinator Barker A Building Maintenance Supervisor Ross N, RLAT, Dip AppSci Animal Bolton S-M Tech (CIT) Hosking A Burke H, BBehaveStudies (Swinburne) Quarantine Technician Storeperson/Maintenance Gooding D, Cert IV Training and Assistant Hunt B Assessment, Dip Animal Technology (CIT) Smith D
Annual Review 2014 55 School Administration
Directorate Outreach and Purchasing Director Communications Unit Dowling E (January-February) Parish CR, BAgrSc (UMelb), PhD (UMelb) Manager Townsend K (from March) (until October) Nicol MJ, BSc (Wollongong), BSc(Hons), Wozniak P, Cert IV GPC Foote SJ, MBBS, DSc, FFSc (RCPA), PhD (ANU) FAHMS, FTSE (from October) Senior Multimedia Officer Safety & Training Deputy Director Edwards K, PhotCert Work Place Health and Safety Bekkers JM, BSc(Hons) (Griffith), MSc Officer (Manchester), PhD (Cambridge) Education Hayes MT, BSc (USyd), MSc (USyd), Business Manager DipEd (Tert) (UNE), PhD (QUT) (until Associate Director Education Cousins M November) and Medical Sciences Graduate Mann D, BSc(Hons) ANU (from Executive Officer to the Director Convener November) Flowers C (from October) Cowan A, BSc(Hons), PhD, GradCertHE Work Place Health and Safety Executive Assistant to Director Assistant Vitler L (until October) Gilmartin L, Cert III Lab Skills (CIT) Reception (part-time) Azzopardi N
SCHOOL SERVICES
Facilities Media & Washup Manager Manager Coombes D Coombes D Facilities Officer Supervisor and Technical Officer Kynoch M Gilmartin L, Cert III Lab Skills (CIT) Operations Assistant Ciuffetelli L Administrative Assistant Dowling E Senior Storeperson Talbot A
56 The John Curtin School of Medical Research The ACRF Biomolecular Resource Facility, Genome Discovery UniT and IMAGING AND CYTOMETRY FACILITY ACRF Biomolecular Genome Discovery Unit Imaging and Cytometry Resource Facility Manager Facility (ICF) Manager Kaehler B, PhD Manager Palmer S, BSc(Hons) (ANU), MBA (Tech Computational Specialists Gillespie CM, GradCertMic (USyd) Management) (Chifley Business School) Buckley B, BA(Hons) (UQ) Histologist Technical Specialist Chuah A, BEng(Hons) (NUS) Prins AS, BAppSci (RMIT) Milburn P, BSc(Hons), PhD (Sheffield) Patel H, BPharm, MBiotech, PhD Flow Cytometry Specialist Genomics Team Research Fellow Vohra H, MSc(Hons) (Punjab), Cripps T, BSc(Hons) PhD (PGIMER) Parker B, BSc (UQ), MBBS (UQ), PhD Higgins A, CBLT (USQ) (USyd) (until April) Flow Cytometry and Microscopy Ohms S, MBChB, ME, PhD (Auck) Bioinformatician Operator Peng K, PhD (Wuhan) Jack C, BSc (Wellington) Devoy M, BSc(Hons) Zhang K, MSc (Fudan), PhD Honorary Visitor Gock A, BAppSci (CSU) (until February) Research Fellow Parker B, BSc (UQ), MBBS (UQ), PhD (USyd) (until May)
Annual Review 2014 57 Students
PhD Students Hussain M, BSc(Hons) Richardson S, BSc(Hons) Achuthan S Hynes C, BSc(Hons) Robertson J, BSc(Adv)(Hons) Agahari F, BSc(Hons) (Japan) Jeelall Y, BBiomedSci(Hons) (UMelb) Roco J Alfaro A (from May) Jiang S, MBBS FRACP Rudinski S, BSc(Hons) Ali E Jiao H Sabouri Z, MD (until November) Al Rumaih Z, MSc(Biotech) Johnson-Saliba M, PhD Samarasinghe K Alshekaili J, MD Jones S, BMedSci(Hons) (UNSW) (until Saxena K, BBiotech March) Andrews S Seamons J Khanna M, BBiomedSci(Hons) (Victoria, Shafik A Anuar ND, BSc(Hons), MSc (Malaysia) Wellington) Shen Q, MBiochem Azad B (from February) Kingston Z Sibritt T, BSc(Hons) Bell S, BSc(Hons) Kolic M Simon Davis DA, BSc(Hons) (Adel) Bergmann H, D.Vet.Med. (Hanover, Lee C Germany) Singh M, BSc(Hons) (Otago) Lee E, BSc, MSc (UC) Bock T, BSc(Hons) (until March) Sinha D, BSc, MSc (India) Lee S, BBiomedSci, MSc (Auck) Chaston D, BSc(Hons) Soetanto R Lehman S Dalefield M Srivastava M, MSc (Rewa) Li J, BMedSci(Hons) (until November) Da Silva E, MBBS, BA, FRACP, FRCPA Tan X, BSc, MSc Li L, BSc (Biotech) Dave P Tran L Lu Y-Z Dhounchak S, BBioTech, MBioTech Trivedi S, BBiotech, MBiotech (Research) (Research) (from March) Mei Y, BSc(Hons) (Ottawa) Velez J Eldi P, MBBS (India) MSc (UQ) Menon D, BBiotech, MBiotech Wagle M, BSc(Hons) (from February) Feakes D Mishra A, BSc, MSc (Nepal) Wang J, BBiomedSc(Hons) (UMelb), Fernando N Mohan A, BTech (India) BSc(Hons) (UMelb) Flower C, BSc (UTAS) Morse A Welham Z, BAppSci(Hons) (from May) Galgamuwe R, MBBS, MSc (Sri Lanka) Morton S, BSc(Hons) Wijesundara D, BBiotech(Hons) (until Gang B, BBiomedSci (Otago) Newman S, BSc(Hons) March) Go M-A, BSc, MSc (U Philippines) Nunez L (from April) Willemse H, BSc(Hons), MSc Gonzalez P Papa I, MPhil (Milan) Wium E, BMedSci(Hons) Han S-Y BSc(Hons) Pratama A, PhB(Hons) Yabas M, MPhil (until August) Hausner S Racic T (from February) Yang H Hu Daniel, BMedSci(Hons) (USyd) Ramiscal R, BSc (UNSW), BSc(Hons) Yap J, MBioTech(Hons) Hu Di Ratnadikawara M Yoon J, BSc, MSc (Pukyong Nat Univ, Korea) Huang H, BBiomedSci(Hons) (Otago) Rebbeck R, BMedSci(Hons) Zhu Y (from May)
58 The John Curtin School of Medical Research MPhil Students MNeuroscience Students MTranslational Medicine Johar A Balodis R Students Li Z, BSc (Beijing Inst Technology) Dean H Alexander P Dong P Barry P Espinoza-Oyarce D Dunn C Honours Students Gotsis S Forster R Abd Hamid M, BSc (from February) Hadad R Rodriguez A Ash O (until June) Haque F Chen T Kaide J Chia RX Owens-Walton C Research Placement Chu-Tan J Ravi I Kherlopian A D’Arcy N Scetrine A Lo L Ferguson L, BSc (from February) Senga S Fernandez P Teasdale H Hall S Zhang T Visiting Scholars Kwong KXM, BSc (from July) Bai B Lambe S, BSc (from February) Hayashi K, (until February) Li F-J, BSc (from February) Gharaei S Loutit A Fazlali Z (from April) Nailer L See M Ng A, BSc (from July) Nguyen N (from July) Roper E Perotti S, BSc (from February) Sarraf S Silva Cayetano A Sparbier C Tam KL, BSc (until July) Tay Y (from July) Townsend D, BSc (from July) Wilson A Wu Y (from July) Young G
Annual Review 2014 59 60 The John Curtin School of Medical Research Publications, Presentations and Community Outreach 2014
Publications: A Full list of publications from JCSMR staff and students in 2014, including: • peer reviewed journal articles • reviews • short communications • book chapters
Presentations made by JCSMR staff and students at local, national and international research institutions, conferences and workshops throughout the year: • Staff presentations • Student presentations
Staff and students of the School continue to sit on numerous editorial boards, to assist with national and international granting bodies as expert assessors, and to belong to many scientific societies. They are also involved with community activities outside the School, some of which are listed.
Annual Review 2014 61 Publications
Abdullah, SN, Sanderson, GF, James, Barbosa, M and James, AC (2014) Joint Gilani, SO, Ohashi, PS, Lang, KS and AC, Vaegan and Maddess, T (2014) iris boundary detection and fit: a real-time Mak, TW (2014) Toso controls Visual evoked potential and psycho- method for accurate pupil tracking. encephalitogenic immune responses physical contrast thresholds in glaucoma. Biomedical Optics Express by dendritic cells and regulatory T cells. Documenta Ophthalmologica 5(8):2458-2470 Proceedings of the National Academy of 128(2):111-120 Barbosa, M, Natoli, R, Valter, K, Sciences of the United States of America Adibi, M, McDonald, JS, Clifford, CWG Provis, P and Maddess, T (2014) 111(3):1060-5 and Arabzadeh, E (2014) Population Integral-geometry characterization of Brizuela, M, Huang, HM, Smith, C, decoding in rat barrel cortex: Optimizing photobiomodulation effects on retinal Burgio, G, Foote, SJ and McMorran, the linear readout of correlated population vessel morphology. Biomedical Optics BJ (2014) Treatment of erythrocytes with responses. PLoS Computational Biology Express 5(7):2317-2332. the 2-cys peroxiredoxin inhibitor, Conoidin 10(1):e1003415 Battefeld, A, Tran, BT, Gavrilis, J, A, prevents the growth of Plasmodium Ali, EN, Maddess, T, James, AC, Cooper, EC and Kole, MH (2014) falciparum and enhances parasite Voicu, C and Lueck, CJ (2014) Pupillary Heteromeric Kv7.2/7.3 channels sensitivity to chloroquine. PLoS One response to sparse multifocal stimuli in differentially regulate action potential 9(4):e92411 multiple sclerosis patients. Multiple initiation and conduction in neocortical Bull, KR, Mason, T, Rimmer, AJ, Sclerosis Journal 20(7):854-861 myelinated axons. Journal of Crockford, TL, Silver, KL, Bouriez-Jones, Altin, JA, Daley, SR, Howitt, J, Neuroscience 34(10):3719-3732 T, Hough, TA, Chaudhry, S, Roberts, ISD, Rickards, HJ, Batkin, AK, Horikawa, K, Bell, A (2014) Constructive interference of Goodnow, CC and Cornall, RJ (2014) Prasad, SJ, Nelms, KA, Kumar, S, Wu, tonal infrasound from synchronised wind Next-generation sequencing to dissect LC, Tan, SS, Cook, MC and Goodnow, farm turbines: evidence and implications. hereditary nephrotic syndrome in mice CC (2014) Ndfip1 mediates peripheral Acoustics Australia 42(3):188-194 identifies a hypomorphic mutation in tolerance to self and exogenous antigen Lamb2 and models Pierson’s syndrome. Bell, A (2014) Annoyance from wind Journal of Pathology 233(1):18-26 by inducing cell cycle exit in responding turbines: role of the middle ear muscles. CD4(+) T cells. Proceedings of the Acoustics Australia 42(1):57 Bunce, D, Bielak, AAM, Anstey, KJ, National Academy of Sciences of the Cherbuin, N, Batterham, PJ and Easteal, United States of America Berghoff, AS, Kiesel, B, Widhalm, G, S (2014) APOE Genotype and 111(6):2067-2074 Rajky, O, Ricken, G, Wöhrer, A, Cognitive Change in Young, Middle-Aged, Dieckmann, K, Filipits, M, Brandstetter, Andoniou, CE, Sutton, VR, Wikstrom, and Older Adults Living in the Community. A, Weller, M, Kurscheid, S, Hegi, ME, Journals of Gerontology Series A-Biological ME, Fleming, P, Thia, KYT, Matthews, Zielinski, CC, Marosi, C, Hainfellner, JA, AY, Kaiserman, D, Schuster, IS, Coudert, Sciences and Medical Sciences Preusser, M and Wick W (2014) 69(4):379-386 JD, Eldi, P, Chaudhri, G, Karupiah, G, Programmed death ligand 1 expression Bird, PI, Trapani, JA and Degli-Esposti, and tumor-infiltrating lymphocytes in Burke, LK, Doslikova, B, D’Agostino, MA (2014) A natural genetic variant of glioblastoma. 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Annual Review 2014 65 sequencing of extreme morbid obesity pa- Ranasinghe, C, Trivedi, S, Sheng, KC, Herrero, LJ, Taylor, A, Hapel, tients: Translational implications for obesity Wijesundara, D and Jackson, RJ AJ and Mahalingam, S (2014) IL-3 and and related disorders. Genes (2014) IL-4 and IL-13 receptors: Roles CSF-1 Interact to promote generation of 5(3):709-725 in immunity and powerful vaccine CD11c+ IL-10-producing macrophages. Perez, CL, Fighera, TM, Miasaki, F, Mesa adjuvants. Cytokine and Growth Factor PLoS One 9(4):e95208 Junior, CO, Paz Filho, GJ, Graf, H and Reviews 25(4):437-442 Siggs, OM, Yates, AL, Schlenner, S, Carvalho, GA (2014) Evaluation of percuta- Rebbeck, RT, Karunasekara, Y, Board, Liston, A, Lesage, S and Goodnow, CC neous ethanol injections in benign thyroid PG, Beard, NA, Casarotto, MG and (2014) A ZAP-70 kinase domain variant nodules. 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66 The John Curtin School of Medical Research Tantirigama, ML, Oswald, MJ, vulpecula). Journal of Comparative Xu, H, Yan, Y, Deb, S, Rangasamy, D, Duynstee, C, Hughes, SM and Empson, Neurology 522(15):3423-3436 Germann, M, Malaterre, J, Eder, NC, RM (2014) Expression of the Walters, SN, Webster, KE, Daley, S and Ward, RL, Hawkins, NJ, Tothill, RW, developmental transcription factor Fezf2 Grey, ST (2014) A Role For Intrathymic B Chen, L, Mortensen, NJ, Fox, SB, identifies a distinct subpopulation of layer Cells in the Generation of Natural McKay, MJ and Ramsay RG (2014) 5 intratelencephalic-projection neurons in Regulatory T Cells. Journal of Immunology Cohesin Rad21 mediates loss of het- mature mouse motor cortex. Journal of 193(1):170-176 erozygosity and is upregulated via Wnt Neuroscience 34(12):4303-8 promoting transcriptional dysregulation Walweel, K, Li, J, Molenaar, P, Imtiaz, MS, Tay, SS, Wong, YC, Roediger, B, Sierro, in gastrointestinal tumors. 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Annual Review 2014 67 Presentations
Associate Professor Ehsan International Mouse Phenotyping Dr Corinne Carle Consortium Annual Meeting, La Pedrera, Arabzadeh Barcelona, Spain Multifocal stimuli presented in spatially- Coding efficiency and sensory adaptation clustered volleys increase SNRs in The Centre for Personalised Immunology pupil perimetry Keynote Lecture, 4th Computational Australian Research Management Society st Neuroscience Workshop, IASBS, 21 International Visual Field and Imaging Conference, National Convention Centre, Symposium, New York, NY, USA Zanjan, Iran Canberra, ACT Models in sensory decision-making Objective perimetry using the pupil response: assessment of visual function ARC Centre of Excellence for Integrative Dr Anneke Blackburn without pushing anyone’s buttons Brain Function, Satellite session on Targeting Cancer Cell Metabolism nd Modeling, University of Queensland, 2 Annual EMBL Australia PhD Course, with Dichloroacetate Brisbane, QLD Canberra, ACT Public Lecture in conjunction with the How normal pupils behave: towards Associate Professor John James Foundation Tony Ayers a predictive model of multifocal pupil Award for Excellence in Translational responses for the identification of Mauricio Arcos - Burgos Medicine, JCSMR Public Lecture Series, visual dysfunction The John Curtin School of Medical Presentation to Yangon University Short Eccles Institute of Neuroscience Seminar Research, ANU, Canberra, ACT Curse on Social and Demographic Series, The John Curtin School of Medical Research Methods Training Polymorphisms in Cyp2r1 and disruption Research, Canberra, ACT of the vitamin D pathway may contribute Department of Anthropology School of to breast cancer susceptibility in mice Culture, History and Language, ANU Associate Professor Ian College of Asia Pacific The Australian Annual Meeting of the Genetics Society of Cockburn National University, Canberra, ACT AustralAsia, Sydney, NSW Genomics and Predictive Medicine: a Targeting cancer metabolism and drug Imaging the CD8+ T cell responses to Contribution without Pharmaceutical Cost resistance with dichloroacetate Plasmodium in the lymph nodes and liver Invited Lecture, University of Rosario, Invited Seminar: Pioneer Valley Life Invited Speaker, Australian Society for Bogota, Colombia Sciences Institute, University of Parasitology Annual Meeting, Massachusetts, Springfield, MA, USA Canberra, ACT Professor John Bekkers Dichloroacetate: More than just a Imaging the CD8+ T cell responses to substrate for Glutathione Transferase Zeta Plasmodium in the lymph nodes and liver Synapses and circuits for the cortical th Invited Speaker, University of Melbourne, processing of odours The 15 Frank and Bobbie Fenner Conference: Professor Philip Board’s Melbourne, VIC nd Plenary Speaker, 32 Australasian Contributions to Molecular Medicine, The Imaging the CD8+ T cell responses to Winter Conference on Brain Research, John Curtin School of Medical Research, Plasmodium in the lymph nodes and liver Queenstown, NZ ANU, Canberra, ACT Invited Speaker, Brisbane Immunology Group Annual Meeting, Gold Coast, QLD Dr Edward Bertram Dr Anne Bruestle How do CD8+ T cells find and Linking causal relationships between MALT1 is an intrinsic regulator of T eliminate parasites in the liver genes and phenotypes of the immune regulatory cells Invited Speaker, University of Washington, system through large scale ENU Seattle, WA, USA mutagenesis of the mammalian genome DGfI T cell Responses Meeting, Marburg, Germany How do CD8+ T cells find and International Symposium of the Korean eliminate parasites in the liver Association for Laboratory Animal My journey with T helper cell subsets in Science, Yeosu, Korea good times and in bad Invited Speaker, Queensland Institute for th Medical Research, Brisbane, QLD The Missense Mutation Library: a 10 Spring School on Immunology, resource of hundreds of thousands of Ettal, Germany new mouse models to study Inflammatory T cell responses - Picking Dr Vincent Daria human disease the brain on Th17 Light-Neuron Interactions: Key to Towards Precision Medicine: Phenotyping JCSMR School Seminar Series, The John understanding the brain human diseases in mice, The 16th Frank Curtin School Of Medical Research, The Invited Speaker: Japanese Society of and Bobbie Fenner Conference, The John Australian National University, Applied Physics – Optical Society of Curtin School of Medical Research, ANU, Canberra, ACT America Joint Symposium, Hokkaido Canberra, ACT University, Hokkaido, Japan The Missense Mutation Library: a School of Physics and Astronomy, resource of hundreds of thousands of University of Glasgow, Glasgow, Scotland new mouse models to study human disease
68 The John Curtin School of Medical Research Institute of Neuroscience and Psychology, Dr Julia Ellyard of the Korean Association for Laboratory University of Glasgow, Glasgow, Scotland Animal Science, Yeosu, Korea Cytokine dysregulation in autoimmune Photonics Department, Technical disease pathogenesis Using mice to understand the human University of Denmark, Risoe, Denmark immune system Cytokines Down Under in 2014: From the th Department of Applied Physics, Osaka Bench to Beyond, Melbourne, VIC 5 Bootes Course on Translational University, Osaka, Japan Medicine, The John Curtin School of Understanding Genetic Causes of SLE in Medical Research, The Australian National Center for Information and Neural the age of Personalised Medicine Networks, Osaka University, University, Canberra, ACT Osaka, Japan Towards Precision Medicine: Phenotyping Primary immunodeficiencies: From mice th human diseases in mice, The 16 Frank to men and Bobbie Fenner Conference, The John Dr Michael Dobbie Curtin School of Medical Research, ANU, Ludwig-Maximilians University, Munich, Germany Balancing the Responsibilities to Animal Canberra, ACT Welfare and Human Health Cytokine dysregulation in autoimmune Professor Simon Foote RSPCA Innovative Methods and disease Alternatives to Animals Symposium, The Cytokines Down Under: From Bench to Invited Speaker Australian National University, Beyond, Melbourne, VIC Tokyo University, Tokyo, Japan Canberra, ACT Whole exome sequencing in early-onset Invited Speaker The Mouse and the Australian Phenomics cerebral SLE identifies a pathogenic Network – Serving Experimental Genetics variant in TREX1 Towards Precision Medicine: Phenotyping human diseases in mice, The 16th Frank Australia-wide th 44 Australasian Society for Immunology and Bobbie Fenner Conference, The John nd 2 Annual EMBL Australia PhD Course, Annual Scientific Meeting, Curtin School of Medical Research, ANU, Canberra, ACT Wollongong, NSW Canberra, ACT Whole exome sequencing in early-onset Invited Observer (representing Australia Dr Guowen Duan cerebral SLE identifies a pathogenic as Observer to Council) variant in TREX1 microRNA and mRNA 3’UTR processing EMBL Meeting, Heidelberg, Germany variations in cardiac biology 6th Australasian Society for Immunology NSW and ACT Annual Branch Retreat, Joint Australia and Japan RNA Meeting, Bowral, NSW Professor CC Goodnow Sydney, NSW Whole exome sequencing in early-onset Germinal Center Selection for Lower Characterization of the interactions cerebral SLE identifies a pathogenic Autoantigen Affinity and for V-Regions between RNA and ‘moonlighting’ variant in TREX1 Blocked by N-Glycans: Redemption of metabolic enzymes in rodent Canberra Health Annual Research Autoantibodies Carried by Anergic B Cells cardiomyocytes and their change in in the Pre-Immune Repertoire response to stress Meeting, Canberra Hospital, Canberra, ACT Keystone Symposium: Biology of B Cell Australian Society for Medical Research Responses, Keystone, CO, USA ACT New Investigators Forum, What does Personalised Medicine in Canberra, ACT Immunology mean? Self-nonself discrimination by antibodies: Sanofi Immunology Master Class, MSGM clonal selection for somatic mutations in Mutations in Roquin prolong microRNA V-regions and in oncogenic longevity in Lupus mice Executive Conference Centres, Macquarie Park, NSW signalling molecules Australian Society for Medical Research UCSF Department of Microbiology & ACT New Investigators Forum, Immunology, San Francisco, CA, USA Canberra, ACT Dr Anselm Enders Self-nonself discrimination by antibodies: Roquin binds microRNA-146a and Expression of IgD on mature B cells is clonal selection for somatic mutations in Argonaute2 and regulates microRNA dependent on zinc-finger protein ZFP318 V-regions and in oncogenic homeostasis in T cells 44th Australasian Society for Immunology signalling molecules 44th Australasian Society for Immunology Annual Scientific Meeting, Genetech Inc, San Francisco, CA, USA Annual Scientific Meeting, Wollongong, NSW Wollongong, NSW Self-nonself discrimination by antibodies: Investigating B cell immunodeficiency clonal selection for somatic mutations in PAR-CLIP profiling of Roquin-bound using ENU mutagenesis V-regions and in oncogenic RNAs in human T cells Invited Seminar: The Walter and Eliza Hall signalling molecules rd 3 NIF Winter School on Advanced Institute of Medical Research, 2014 Cold Spring Harbor Meeting, Gene Immunology, Awaji Island, Japan Melbourne, VIC Expression and Signaling in the Immune Primary immunodeficiencies: From mice System, Cold Spring Harbor, NY, USA to men Self-nonself discrimination by antibodies: Invited speaker: International Symposium clonal selection for somatic mutations in
Annual Review 2014 69 V-regions and in oncogenic Associate Professor Guna RBP atlas: an exploration of interactions signalling molecules Karupiah between mRNA and proteins and their Stanford University, San Francisco, impact on cardiomyocyte biology CA, USA Induction of long-lived antiviral Canberra Health Annual Research antibody responses Recurring mutations in human lymphoid Meeting, Canberra Hospital, cancer switch inhibitory signals from QIMR Berghofer Medical Research Canberra, ACT normal self into growth stimulatory signals Institute, Brisbane, QLD RBP atlas: an exploration of interactions 7th Garvan Signalling Symposium, Garvan between mRNA and proteins and their Institute of Medical Research, Professor Trevor Lamb impact on cardiomyocyte biology Sydney, NSW Evolution of vertebrate photoreception and ComBio 2014, Canberra, ACT Mendel’s Long tail: the impact of mis- retinoid cycle: Clues from agnathans sense mutations on immunity EEMB Seminar Series, University of Associate Professor Brett Towards Precision Medicine: Phenotyping California Santa Barbara, Santa Barbara, Lidbury human diseases in mice, The 16th Frank CA, USA and Bobbie Fenner Conference, The John Absolute replacement concepts for Evolution of vertebrate photoreception and biomedical research and the scientific Curtin School of Medical Research, ANU, retinoid cycle: Clues from agnathans. Canberra, ACT challenge of human diversity Invited speaker: International Society for RSPCA Innovative Methods and Eye Research, XXI Biennial Meeting, San Professor Jill Gready Alternatives to Animals Symposium, The Francisco, CA, USA Australian National University, Research focused on Global Sustainable Evolution of vertebrate photoreception: Canberra, ACT Food Provision Clues from hagfish and lamprey Fluorescent Target Array reduces mouse Invited speaker: The Future of the eye transcriptomes numbers while assessing multiple post- University and the University of the Future: Invited Seminar: Neuroecology Group, vaccination T-cell responses A Global Perspective, Universidad Técnica University of Western Australia, Perth, WA 9th World Congress on Alternatives and de Ambato, Ecuador Evolution of vertebrate photoreception: Animal Use in the Life Sciences, Prague, Clues from hagfish and lamprey Czech Republic Dr Rebecca Haddock eye transcriptomes Proton magnetic resonance spectroscopy State of the Heart Invited conference presentation: Genes, and recursive partitioning analysis of brain Epigenetics and Evolution in Eye metabolism data from an Alzheimer’s Australian Vascular Biology Society / Development and Disease, disease cohort offers a replacement High Blood Pressure Society of Australia, Oropesa, Spain alternative for animal studies on Adelaide, SA disease prediction Evolution of vertebrate photoreception Obesity-related hypertension: Interaction th and retinoid cycle: Clues from the eye 9 World Congress on Alternatives and of the immune and sysmpathetic transcriptome of basal vertebrates Animal Use in the Life Sciences, Prague, nervous systems Czech Republic Invited seminar, Departament de Genètica, Experimental Biology (American Universitat de Barcelona, Barcelona, Spain Physiological Society), San Diego, Professor Ted Maddess CA, USA Extraction of photoreceptor and bipolar cell responses from the ERGs of normal human Structure and Function in Multifocal Perivascular inflammation drives subjects Pupillographic Objective Perimetry sympathetic hyperinnervation and (mfPOP) hypertension in obesity Invited seminar, Institute of Ophthalmology, University College, London, UK Imaging and Perimetry Society, New York, Combined Research Forum, Canberra NY, USA Hospital, Canberra, ACT Evolution of vertebrate photoreception and retinoid cycle: Clues from the eye Structure and Function in Multifocal Cause of Hypertension in the Obese transcriptome of basal vertebrates Pupillographic Objective Perimetry 5th Bootes Course on Translational Invited seminar, Kenneth Craik Club, (mfPOP) Medicine, The John Curtin School of University of Cambridge, Cambridge, UK World Ophthalmology Congress, Medical Research, The Australian National Tokyo, Japan University, Canberra, ACT Obesity and the Nervous system Dr Yalin Liao Dr Claudio Mastronardi 2nd Annual EMBL Australia PhD Course, RBP atlas: an exploration of interactions Canberra, ACT between mRNA and proteins and their Temporal gene expression in the impact on cardiomyocyte biology hippocampus and peripheral organs in Joint Japanese and Australia RNA mice resilient to systemic meeting, Sydney, NSW inflammatory response
70 The John Curtin School of Medical Research 9th Congress of the International Society Plenary lecture: 31st Brazilian Congress of A novel triple action mucosal/systemic for NeuroImmunoModulation, Endocrinology and Metabolism, HIV-1 vaccine strategy Liege, Belgium Curitiba, Brazil AIDS2014 Symposia Session Twenty Years of Leptin Determinants of Transmission: Dr Maxim Nekrasov São Paulo State University (UNESP) Interactions with Biomedical Prevention Strategies, Melbourne, VIC Different Strategies of chromatin School of Medicine, São Paulo, Brazil remodelling at the trasncription start site Whole-exome sequencing for the Dr Stuart Read ComBio 2014, Canberra, ACT diagnosis of monogenic obesity São Paulo State University (UNESP) Missense Mutation Library; Hundreds Professor Christopher R School of Medicine, São Paulo, Brazil of thousands of mouse models for understanding human disease Parish Translational Medicine International Mouse Phenotyping Translational and Clinical Sciences Pathways to the development of novel Consortium Annual Meeting, Workshop, 2nd Annual EMBL Australia drugs against cancer, diabetes and sepsis Barcelona, Spain PhD Course, Canberra, ACT 2nd Annual EMBL Australia PhD Course, Canberra, ACT Professor Thomas Preiss Associate Professor Type 1 diabetes and sepsis at JCSMR: Charmaine Simeonovic Heparan sulphate mimetics Mechanisms and patterns of eukaryotic as therapeutics post-transcriptional gene control Depletion of intracellular heparan sulfate in islet beta cells: a critical link between Speaker & Session Chair: CSH Asia RNA Paediatric Grand Rounds, The Canberra Type 1 diabetes and Type 2 diabetes Hospital, Canberra, ACT Biology Conference, Suzhou China Department of Internal Medicine III, Mechanisms and patterns of eukaryotic The pathway from lab finding to Medical Faculty Carl Gustav Carus, post-transcriptional gene control clinical trial Dresden University of Technology, 5th Bootes Course on Translational IUPAB International Biophysics Congress, Dresden, Germany Brisbane QLD Medicine, The John Curtin School of Depletion of intracellular heparan sulfate Medical Research, The Australian National Role of the 5-methylcytosine as a in islet beta cells: a critical link between University, Canberra, ACT widespread modification of RNA Type 1 diabetes and Type 2 diabetes FASEB SRC: Machines on Genes: School of Medicine, University of Dr Hardip Patel Nucleic Acid Enzymes, Snowmass, Tampere, Tampere, Finland CO, USA RNAnexus: A framework for RNA data Depletion of intracellular heparan sulfate mining and visualization Importance of RNA-mediated in islet beta cells: a critical link between gene regulation Type 1 diabetes and Type 2 diabetes Annual Meeting of the Genetics Society of AustralAsia, Sydney, NSW Co-convenor, session chair & speaker, Department of Biological and 2nd Annual EMBL Australia PhD Course, Environmental Science, University of Canberra, ACT Dr Gilberto Paz-Filho Jyväskylä, Jyväskylä, Finland RNA-mediated gene regulation in Depletion of intracellular heparan sulfate Leptin therapy: facts and expectations cardiac biology in islet beta cells: a critical link between The Australian Institute of Sport, 5th Bootes Course on Translational Type 1 diabetes and Type 2 diabetes Canberra, ACT Medicine, The John Curtin School of Institute of Biomedical and Clinical Overview of Translational Medicine Medical Research, The Australian National Science, University of Exeter Medical University, Canberra, ACT School, Exeter, UK 5th Bootes Course on Translational Medicine, The John Curtin School of Mechanisms and patterns of eukaryotic Depletion of beta cell heparan sulfate (HS) Medical Research, The Australian National post-transcriptional gene control in T2D-prone db/db mice results from University, Canberra, ACT Julian Wells Medal Lecture, Australian diminished heparan sulfate proteoglycan (HSPG) core protein levels Endocrine Research in Brazil and Turkey Genome Conference, Lorne, VIC Annual Scientific Meeting of the 5th Bootes Course on Translational Australian Diabetes Society and the Medicine, The John Curtin School of Dr Charani Ranasinghe Australian Diabetes Educator Association, Medical Research, The Australian National HIV vaccines eliciting broad Melbourne, VIC University, Canberra, ACT protective responses Depletion of intracellular heparan sulfate Pathways for a career overseas AIDS2014 ACH2 satellite meeting, in islet beta cells: a critical link between 31st Brazilian Congress of Endocrinology International Master class and workshop Type 1 diabetes and Type 2 diabetes and Metabolism, Curitiba, Brazil on HIV prevention, control and cure, Department of Immunology Seminar Doherty Institute, Melbourne, VIC ENDO Tribute: Twenty years of the Series, The John Curtin School of Medical revolutionary leptin Research, ANU, Canberra, ACT
Annual Review 2014 71 Associate Professor Dr Malinda Tantirigama Professor Carola G Vinuesa Christian Stricker Laminar representation of odour in the T cell subsets that control B cell A trp into ion channels involved in mouse piriform cortex in vivo responses: More than meet the eye thymocyte selection 32nd Australasian Winter Conference on Cell Symposium: The Multifaceted Roles Eccles Institute of Neuroscience Seminar Brain Research, Queenstown, NZ of Type 2 Immunity, Bruges, Belgium Series, The John Curtin School of Medical Laminar representation of odour in the MicroRNA-mediated repression of T Research, The Australian National University, mouse piriform cortex in vivo follicular helper cells and germinal centers Canberra, ACT UWS Sensory Neuroscience Symposium, 3rd International Conference on Immune Single-cell techniques in Neuroscience Sydney, NSW Tolerance, Amsterdam, Netherlands unravelling brain function Tfh Cell Regulation to Prevent 2nd Annual EMBL Australia PhD Course, Professor David Tremethick Systemic Autoimmunity Canberra, ACT Uncovering new functions of chromatin: FOCIS 2014, Annual Meeting of the the role of histone variants in Federation of Clinical Immunology Professor Greg Stuart pre mRNA splicing Societies, Chicago, IL, USA Brain mechanics: The nuts and bolts of EMBO workshop on histone variants, miRNA-mediated control of Tfh cells and how your brain works Strasbourg, France germinal center responses 4th Annual John Curtin Lecture in Medical Inheritance of H2A.Z from cell generation Immunology 2014 Symposium: Genetic Research, Canberra, ACT to the next Control of Immunity, Pittsburgh, PA, USA Dendritic integration Asian Transcription meeting, Regulation of Tfh cell numbers and function Okinawa Computational Neuroscience Melbourne, VIC th Course, Okinawa, Japan A new role for histone variants in 27 Annual Meeting of the Canadian splicing regulation Society of Immunology: Germinal Center Axons & excitability Reaction in Health and Disease, Okinawa Computational Neuroscience Gordon conference: Chromatin Structure Quebec, Canada and Function, Boston, MA, USA Course, Okinawa, Japan Novel Mechanisms Controlling Mouse Binocular integration Uncovering new functions of chromatin: and Human Follicular T Cell Homeostasis functional specialisation by Allen Brain Institute, Seattle, WA, USA histone variants Keystone Symposium: Biology of B Cell Responses, Keystone, CO, USA Single neuron computation School of Molecular and Biomedical Monash Neuroscience Seminar Series, Sciences, The University of Adelaide, Multiple mechanisms operate to regulate Monash University, Melbourne, VIC Adelaide, SA T cell help for B cells 3rd NIF Winter School on Advanced Dr Rebecca Sweet Dr Krisztina Valter Immunology, Awaji Island, Japan Why do we still know so little about Photobiomodulation with 670nm in Human T follicular regulatory cells are autoimmune disease aetiology? the source of IL-10 to drive plasma cell models of retinal degeneration The Jonathan Sprent Oration, Brisbane differentiation from germinal center B cells Invited keynote presentation: Australian Immunology Group 15th Annual Retreat, th Medical Laser Association, Sydney, NSW 6 Australasian Society for Immunology QIMR-Berghofer Medical Research NSW and ACT Annual Branch Retreat, 670nm – a stop sign for Institute, Gold Coast, QLD Bowral, NSW retinal degeneration? Human T follicular regulatory cells signal Invited keynote presentation: World Dr Stephen Winslade directly to germinal centre B cells Association for Laser Therapy/ using IL-10 North American Association for Translational Commercialisation Australian Society for Medical Research Photobiomodulation Therapy Joint of Research ACT New Investigators Forum, conference, Washington, DC, USA Asian Mouse Phenotyping Consortium Canberra, ACT Discussions on the mechanism of 670nm Student Workshop, Canberra, ACT Human T follicular regulatory cells signal light treatment on the retina directly to germinal centre B cells Invited symposium presentation: using IL-10 World Association for Laser Therapy Canberra Health Annual Research - North American Association for Meeting, Canberra Hospital, Photobiomodulation Therapy Joint Canberra, ACT conference, Washington, DC, USA
72 The John Curtin School of Medical Research Student Presentations
S Achuthan and AC H Bergmann P Eldi Blackburn Removal of p8-CD74 peptides by Induction of long-term humoral immunity Targeting glucose metabolism - a strategy intramembrane endopeptidase SPPL2A is using replicating and non-replicating for overcoming drug resistance in crucial for B cell survival poxviral models breast cancer Departmental of Immunology Seminar, 44th Australasian Society for Immunology ComBio 2014, Canberra, ACT Whitehead Institute, Boston, MA, USA Annual Scientific Meeting, Wollongong, NSW Targeting glucose metabolism — a Complete degradation of CD74-invariant strategy for overcoming drug resistance in chain by the endopeptidase SPPL2A is breast cancer necessary for B cell responsiveness and N Fernando survival Canberra Health Annual Research The therapeutic potential of the th Meeting, Canberra Hospital, 44 Australasian Society for Immunology complement inhibitor VCP in a model of Canberra, ACT Annual Scientific Meeting, Wollongong, NSW retinal degeneration Removal of p8-CD74 peptides by 16th European Molecular Biology FA Agahari and C Stricker intramembrane endopeptidase SPPL2A is Laboratory (EMBL) International PhD crucial for B cell survival Symposium, Heidelberg, Germany Serotonergic modulation of neurotransmitter Keystone Symposia: Biology of B cell The use of the complement inhibitor VCP release in layer II/III pyramidal neurons in rat Responses, Keystone, CO, USA somatosensory cortex in the retina st th 1 European Molecular Biology 34 Annual Meeting of the Australasian T Bock Neuroscience Society, Adelaide, SA Laboratory (EMBL) Australia PhD Impact of SK Channels on cortical Symposium, The University of New South Opposite modulation of spontaneous and Wales, Sydney, NSW evoked transmitter release in layer II/III excitability in vivo pyramidal cell in rat somatosensory cortex 34th Annual Meeting of the Australasian through 5-HT2 Gq-protein-coupled Neuroscience Society, Adelaide, SA R Galgamuwa Arachchige, receptor (GqPCR) PG Board, JE Dahlstrom, AC Meeting of the Society of Neuroscience, RH Chia, R Mallikarjunan, Blackburn, P Tummala, L Washington, USA CF Carle et al. Tian and A Theodoratos EN Ali, T Maddess, CF Carle Objective perimetry in diagnosing early Dichloroacetate (DCA) prevents cisplatin- retinopathy in type II diabetes induced acute kidney injury (AKI) by and CJ Lueck regenerating renal tubular cells while Australian Diabetes Society & Diabetes anticancer activity of cisplatin is unaltered. Effects of stimulating melanopsin- Education Association containing retinal ganglion cells in Australian and New Zealand Society of migraine patients using multifocal Nephrology (ANZSN) Annual Scientific objective pupillometry S Dhounchak, S Popp, H Meeting, Canberra, ACT Vohra, T Biden, R Laybutt, C EFNS-ENS Joint Congress of European Neurology, Istanbu Turkey Parish and C Simeonovic R Galgamuwa Arachchige, Diminished heparan sulfate proteoglycan PG Board, JE Dahlstrom, AC EN Ali, T Maddess, K Martin, (HSPG) core protein levels correlate with Blackburn, P Tummala and A Borbell and CJ Lueck the depletion of heparan sulfate (HS) in the islets of T2D-prone db/db mice A Theodoratos Testing the safety of multifocal Australian Islet Study Group Meeting (AISG), Dichloroacetate (DCA) prevents cisplatin- pupillographic objective perimetry (mfPOP) Brisbane, QLD induced acute kidney injury (AKI) by in patients with photosensitive epilepsy regenerating renal tubular cells Beta cell heparan sulfate and heparan Canberra Health Annual Research sulfate proteoglycan loss in Type 2 Diabetes 20th International Conference on Meeting, Canberra Hospital, Advances in Critical Care Nephrology, Australian Society for Medical Research Canberra, ACT San Diego, CA, USA (ASMR) ACT New Investigator Forum, Canberra, ACT Z Al Rumaih The role of viral TNFR (crmD) in the host response to poxvirus infection 44th Australasian Society for Immunology Annual Scientific Meeting, Wollongong, NSW
Annual Review 2014 73 S Gharaei, E Arabzadeh and H Huang M Khanna, C Ranasinghe, S Solomon Principal neurons respond differently to odour RJ Jackson and CR Parish Distribution of visual and somatosensory presentation in vivo Role of heparan sulfate in pox virus signals in superior colliculus of rat 34th Annual Meeting of the Australasian infections Kioloa Neuroscience Colloquium, Kioloa Neuroscience Society, Adelaide, SA Keystone symposia, Denver, CO, USA Coastal Campus Principal neurons respond differently to odour Distribution of visual and somatosensory presentation in vivo C Lee and E Arabzadeh signals in superior colliculus of rat Kioloa Neuroscience Colloquium, Kioloa, NSW A novel investigation of sensory th 34 Annual Meeting of the Australasian Probing neuronal responses with scents prioritization in rats Neuroscience Society, Adelaide, SA Eccles Institute of Neuroscience Seminar Kioloa Neuroscience Colloquium, Kioloa Series, The John Curtin School of Medical Coastal Campus M-A Go Research, The Australian National University, Canberra, ACT Femtosecond laser dendrotomy D Menon th 34 Annual Meeting of the Australasian Y Jeelall Redox modification of proteins: Neuroscience Society, Adelaide, SA Glutathione transferase Omega 1 Femtosecond laser dendrotomy CARD11 as the switch between (GSTO1-1) as a deglutathionylase (Oral self-antigen induced B cell death or and Poster presentation) Focus on Microscopy, University of proliferation and autoantibody production Sydney, Sydney, NSW (Oral and Poster presentation) Gordon Research Conference: Thiol based redox regulation and signalling, Analysing neuronal function using Keystone Symposia: Biology of B cell Girona, Spain synthesizable photo-switchable responses, Keystone, CO, USA nanoparticle agents Redox modification of proteins: A novel deep sequencing method for Glutathione transferase Omega 1 Federation of Neurosciences Society tracking of driver mutations in non- (GSTO1-1) as a deglutathionylase Meeting, Milan, Italy Hodgkin lymphoma 15th IUBMB-24th FAOBMB Conference Femtosecond laser dendrotomy for Canberra Health Annual Research Taipei, Taiwan analyzing morphology dependent Meeting, Canberra Hospital, neuronal function Canberra, ACT Glutathione transferase Omega 1 is a novel redox regulator of TLR4-dependent Federation of Neurosciences Society Investigating genetic lesions associated inflammatory signalling in macrophages Meeting, Milan, Italy with DLBCL cases 15th IUBMB-24th FAOBMB Conference: Analysing morphology-dependent Agilent Next Generation Sequencing Young Scientist Program- (Oral and neuronal function using laser dendrotomy Seminar, Canberra, ACT Poster presentation), Taichung, Taiwan Society for Neuroscience, Washington Novel sequencing methods for tracking Glutathione Transferase Omega 1 is a DC, USA driver mutations in non-Hodgkin novel redox signalling protein in TLR4 lymphoma activated macrophages F Haque, D Nisbet, F Department of Immunology Seminar The 15th Frank and Bobbie Fenner Maclean and JR Potas Series, The John Curtin School of Medical Conference: Professor Philip Board’s Research, ANU, Canberra, ACT Contributions to Molecular Medicine, The In vivo macrophage polarisation induced John Curtin School of Medical Research, by interleukin 10 (IL10) functionalised Characterisation of an ENU-induced ANU, Canberra, ACT electrospun nanofibre scaffolds in the gain-of-function Card11 mouse strain as peripheral nervous system a model for human B cell diseases Glutathione transferase Omega 1 is a th novel redox regulator of TLR4-dependent 34th Annual Meeting of the Australasian 44 Australasian Society for Immunology inflammatory signalling Neuroscience Society, Adelaide, SA Annual Scientific Meeting, Wollongong, NSW Australian Society for Medical Research New Investigator Forum, Canberra, ACT D Hu, S Zhu and JR Potas S Jones Red light (670 nm) treatment improves A Micallef functional and cellular outcomes following Action potential induced suppression of spinal cord injury EPSPs by SK channels in dendrites A postsynaptic contribution to short-term plasticity in the piriform cortex UWS Sensory Neuroscience Symposium, 34th Annual Meeting of the Australasian University of Western Sydney, Neuroscience Society, Adelaide, SA 34th Annual Meeting of the Australasian Sydney, NSW Neuroscience Society, Adelaide, SA
74 The John Curtin School of Medical Research J Robertson K Samarasinghe, D Liu, P Q Shen Electrical stimulation alters patterns of Tummala, L Arnolda, A F Repression of LINE-1 Transcription epileptiform activity in the piriform cortex Dulhunty and PG Board by H2A.Z in vivo nd The therapeutic potential of Glutathione The 2 Max Planck Freiburg Epigenetic th 34 Annual Meeting of the Australasian transferase Mu-derived peptides to treat Meeting, Freiburg, Germany Neuroscience Society, Adelaide, SA heart failure through cardiac ryanodine Using hyper-excitability to probe piriform receptor Ca2+ channel inhibition T Sibbritt, BJ Parker, DT cortex networks Australian Society for Medical Research Humphreys, JE Squires. UWS Sensory Neuroscience Symposium, New Investigator Forum, Canberra, ACT NJ Beveridge, A Shafik, AL Sydney, Australia The therapeutic potential of Glutathione Statham, HR Patel, SJ Clark Changing electrical activity in the primary transferase M2-derived peptides to treat olfactory cortex: what a shock! heart failure through cardiac ryanodine and T Preiss receptor Ca2+ channel inhibition Australian Society for Medical Research Exploring the role of RNA cytosine New Investigator Forum, Canberra, ACT 43rd European Muscle Conference methylation in post-transcriptional gene Faculty of Natural Sciences, University of regulation and cancer Changing epileptic activity in the primary Salzburg, Salzburg, Austria olfactory cortex ComBio 2014, Canberra, ACT Canberra Health Annual Research Investigating the enzymology and Meeting, Canberra Hospital, | S Senga S, Z-M Song and molecular function of 5-methylcytosine Canberra, ACT GDH Croaker in RNA Diffuse effects of an endothelin b receptor Joint Australia and Japan RNA Meeting, A Rodriguez, G Paz–Filho, T (ednrb) mutation: more on the non-enteric Sydney, NSW Neeman, AG Giles and CA phenotype of Hirschsprung's disease The mysteries of RNA methylation: Mastronardi Canberra Health Annual Research exploring the enzymology and molecular Meeting, Canberra Hospital, function of 5-methylcytosine in RNA Metreleptin improves metabolic and Canberra, ACT Gordon Research Conference: Post- hepatic endpoints in the treatment of transcriptional Gene Regulation, Newport, non-HAART associated lipodystrophy RI, USA syndromes: a meta-analysis into the A Shafik, N Beveridge, T effects of leptin replacement therapy Sibbritt, JE Squires, DT T Sibbritt, BJ Parker, DT Annual Scientific Meeting of the Endocrine Humphreys, HR Patel, SJ Humphreys, HR Patel, AL Society of Australia, Melbourne, VIC Clark, J Wen, BJ Parker and Statham, SJ Clark and T A Meta-Analysis into the Effects of Leptin T Preiss Replacement Therapy on Metabolic Preiss and Hepatic Endpoints of Patients Enzymology and molecular function of with Lipodystrophy Syndromes Not 5-methylcytosine (m5C) as a modification Investigating the association of RNA Associated with the Use of HIV of human RNA cytosine methylation with post- transcriptional regulation and cancer Protease Inhibitors 35th Annual Lorne Genome Conference, Annual Scientific Meeting of The Lorne, VIC, Australia Australian Society for Medical Research Endocrine Society, Chicago, IL, USA New Investigator Forum, Canberra, ACT A Shafik, T Sibbritt, HR Investigating the association of RNA cytosine methylation with post- Patel, N Beveridge, SJ transcriptional regulation and cancer Clark, J Wen, BJ Parker and 35th Annual Lorne Genome Conference, T Preiss Lorne, VIC Enzymology and molecular function of 5-methylcytosine (m5C) as a modification M Singh of human RNA Oral Presentations Australian Society for Medical Research 44th Australasian Society for Immunology New Investigator Forum, Canberra, ACT Annual Scientific Meeting, Wollongong, NSW Oral presentation Croucher Summer Course: Advances in Immunology in Health and Disease, Hong Kong
Annual Review 2014 75 R Soetanto, CJ Hynes, B Tonson-Older, T Maddess, D Xie, GDH Croaker, K HR Patel, D Duan, DT J Bell and CJ Lueck Stefanoska and Z-M Song Humphreys, NJ Smith, Automated perimetry in neurological Developing a model for studying late BJ Parker, SK Archer, TH visual field loss effects of ednrb malfunction on Beilharz, RM Graham, JL Neuro-Ophthalmology Society of brain development Clancy and T Preiss Australia, Canberra, ACT Canberra Health Annual Research Automated perimetry in neurological Meeting, Canberra Hospital, The dynamics of miRNA-mRNA targeting visual field loss Canberra, ACT during cardiac health and disease Canberra Health Annual Research st 1 European Molecular Biology Laboratory Meeting, Canberra Hospital, M Yabas (EMBL) Australia PhD Symposium, The B cell deficiency and anemia caused by University of New South Wales, Sydney, Canberra, ACT mutations in the murine Atp11c gene NSW Erciyes University, Kayseri, Turkey mRNA 3’UTR expression during cardiac LTV Tran and C Stricker disease: consequences for miRNA Spontaneous Ca2+ transients in nerve regulation terminals of neocortical Y Zhang, L Boisseau, P ComBio 2014, Canberra, ACT excitatory neurons Scott, G Paz–Filho and C Alternative RNA 3’ end cleavage 34th Annual Meeting of the Australasian Nolan and polyadenylation during cardiac Neuroscience Society, Adelaide, SA Is the Strategy for Care of "Low Risk" hypertrophy, Rina Soetanto, Joint Women with Gestational Diabetes Mellitus Australia and Japan RNA Meeting, Spontaneous Ca2+ transients in nerve Really Safe? Sydney, NSW terminals of neocortical excitatory neurons 74th ScientificS essions of the American Expression of mRNA 3’UTR isoforms in Diabetes Association, San Francisco, the heart Meeting of the Society of Neuroscience, Washington, USA CA, USA Australian Society for Medical Research New Investigator Forum, Canberra, ACT DK Wijesundara, RJ S Zhu, D Hu and JR Potas Shifting targets: microRNA variants and alternative polyadenylation in the heart Jackson, DC Tscharke and Brainstem changes affected by 670 nm photobiomodulation treatment following 35th Annual Lorne Genome Conference, C Ranasinghe T10 hemi-contusion spinal cord injury Lorne, VIC HIV-1 vaccine development: evaluating 34th Annual Meeting of the Australasian Shifting targets: microRNA variants and mechanisms by which interleukin (IL)-4 Neuroscience Society, Adelaide, SA alternative polyadenylation in the heart and IL-13 down-regulate the quality of anti-viral HIV-specific CD8+ T cell Canberra Health Annual Research responses following pox viral vaccination Meeting, Canberra Hospital, Canberra, ACT International AIDS2014 Conference, Melbourne, VIC Mending a broken heart- a big role for small RNAs 3-Minute Thesis Competition, The DK Wijesundara, C Australian National University, Ranasinghe, RJ Jackson, Canberra, ACT CR Parish and B Quah B Mending a broken heart- a big role for Assessing the quality of CD8+ T cell small RNAs responses in vivo following HIV-1 The Science Show, ABC Radio National recombinant pox virus vaccination using a novel fluorescent target array assay I Tea, E Martineau, J ACH2, Katoomba, NSW Lalande, S Barille, AC Blackburn and G Tcherkez4 Y-H Wu, JE Dahlstrom, DJ Isotopic signature of 13C and 15N natural Tremethick and T Soboleva abundance in breast cancer A new function for testis-specific histone ComBio 2014, Canberra, ACT variants in cancer Canberra Health Annual Research Meeting, Canberra Hospital, Canberra, ACT
76 The John Curtin School of Medical Research Community
Dr Mehdi Adibi Professor Mauricio Dr Edward M Bertram Participant: CSIRO Scientists and Arcos-Burgos Steering Committee Member: Mathematicians in Schools, Campbell Editorial Board Member: Molecular International Mouse High School, Canberra, ACT Genetics and Genomics Medicine Phenotyping Consortium Editorial Reviewer: Nature Genetics; Member: Finance Sub-Committee, Ms Ana Alfaro Molecular Psychiatry; Human Genetics, International Mouse Phenotyping Consortium Presenter and Participant: JCSMR Nephron; Bioinformatics; Translational Open Day Psychiatry, Annals of Human Genetics, Australian Member: Board of Directors, The ANU Undergraduate Asian Mouse Phenotyping Consortium Presenter and Participant: First Canberra Research Journal Ecuadorian Festival, Acton, ACT Conference Organiser: Towards Precision Medicine: Phenotyping human diseases in Professor John M Bekkers mice, Canberra, ACT Ms Nurdiana Anuar Director: Australian Course in Advanced Workshop Organiser and Session Chair: Vice President: Malaysian Postgraduate Neuroscience (ACAN), Moreton Bay Asian Mouse Phenotyping Consortium Student Association-ACT chapter Research Station, North Stradbroke Student Workshop, Canberra, ACT Volunteer: Combio 2014, National Island, QLD Meeting Organiser: Asian Mouse Convention Centre, Canberra ACT Reviewing Editor: Frontiers in Mutagenesis and Resource Association- Neuroscience, BMC Neuroscience Asian Mouse Phenotyping Consortium Annual Meeting, Canberra, ACT Associate Professor Ehsan Chair: JCSMR Scholarships Committee Arabzadeh Convenor: JCSMR School Dr Anneke Blackburn Academic Editor: Public Library of Seminar program Science, PLoS One Member: JCSMR Executive Committee Convenor: JCSMR Cancer Research Consumer Representative Panel, The Presenter: JCSMR Director’s ‘Health Member: JCSMR Education Committee John Curtin School of Medical Research through Discovery’ Public Lecture, Member: ANU Neuroscience and Research School of Biology, The Deciphering the language of brain cells Management Committee Australian National University, Panellist, public event “Who is in charge, Canberra, ACT Member: JCSMR Grant Feedback you or your brain?” ARC Centre of Committee (Neuroscience) Presenter: Cancer Council ACT: Biggest Excellence for Integrative Brain Function, Morning Tea Launch Victorian State Library, Melbourne Council Member: Australasian Neuroscience Society Presenter: Breast Cancer Treatment Spokesperson, Decision theme, ARC Group (Cancer support network) Centre of Excellence for Integrative Ex officio Member: ACAN Management Brain Function Committee of the Australasian Media Interviews: WIN News, ABC News, Neuroscience Society The Canberra Times: Non-toxic drug Academic Council Member: Institute targets cancers sweet spot for Research in Fundamental Sciences, Member: Australian Physiological Society Member: ASBMB Australian Society for Tehran, Iran Member: Society for Neuroscience (USA) Biochemistry and Molecular Biology Faculty: Australian Course in Advanced Member: International Brain Research Presenter and Host: JCSMR Outreach Neuroscience (ACAN), North Stradbroke Organization (IBRO) Island, QLD Program, Canberra, ACT Presenter and Participant: National Youth Member: American Association for Co-organiser, Kioloa Neuroscience Science Forum, JCSMR, ANU, Cancer Research Colloquium, Kioloa Coastal Campus Canberra, ACT Member: Kathleen Cunningham Member: Neuroscience Honours Presenter and Host: JCSMR Outreach Consortium for Research into Familial Committee, JCSMR, ANU, Program, Canberra, ACT Canberra, ACT Breast Cancer (kConFaB) Member: JCSMR Gender Dr Andrew Bell Equity Committee Consulting Editor: Journal of Member: Australasian Hearing Science Neuroscience Society Member: Australian Acoustical Society Member: Society for Neuroscience (USA) Member: Acoustical Society of America
Annual Review 2014 77 Professor Philip G Board Member: USA Biophysical Society Dr Lucy Coupland Member: ACT Gene Technology NHMRC Grant Review Panel Member: Category B Member: Animal Advisory Council Biochemistry and Cell Biology Experimentation Ethics Committee, ANU Member: International Society for the Study of Xenobiotics Awards Committee Dr G Chaudhri Ms Tiffany Cripps Editorial Board Member: The Open Drug Member: Federation of Clinical Presenter and Participant: JCSMR Metabolism Journal, Drug Metabolism Immunological Societies Outreach Program - ANU BIOL3190 Reviews, The Sirraj Medical Journal Member: Australasian Society Science in the Workplace for Immunology Mr Bob Buckley Member: Australian Society for Dr Peter Cummins Medical Research Convenor: Autism Aspergers Advocacy Presenter and Participant: JCSMR Australia (A4) Open Day Chair: Speaking Out for Autism Spectrum Dr Julian Choy Disorder (SOfASD) Presenter and Participant: JCSMR Dr Stephen Daley Finalist: 2014 ACT Senior Australian of Open Day ACT Branch Treasurer: Australasian the Year Presenter and Participant: National Youth Society for Immunology Panel Member: NDIA’s Autism Early Science Forum, JCSMR, ANU, Intervention Review Canberra, ACT Dr Vincent Daria Presenter: NDIS pre-planning workshops Presenter and Participant: Australian for autism Brain Bee Challenge, ACT Regional Member: Australasian Finals, JCSMR, ANU, Canberra, ACT Neuroscience Society Ms Holly Burke Member: Australasian Member: Society for Neuroscience (USA) Neuroscience Society Member: Australian Optical Society Member: Australian and New Zealand Laboratory Animal Association Member: Society for Neuroscience (USA) Member: Optical Society of America Conference Organiser: Australian Member: International Society for Optics and New Zealand Laboratory Animal Mr Aaron Chuah and Photonics Association Annual Conference Presenter: GDUcluster for users. Techniques in Computational Genomics Dr Michael Dobbie Dr Corinne Carle Series, The John Curtin School of Medical Research, ANU, Canberra, ACT Member: Australia & New Zealand Member: Australiasian Society for Cell & Developmental Biology Neuroscience Society (ANZSCDB) Associate Professor Ian Member: Association for Research in ScientificC o-convenor: EMBL Australia Vision and Ophthalmology (ARVO) Cockburn PhD Course, The Australian National University, Canberra, ACT Convenor: JCSMR Eccles Institute of Module Organiser: Australian Society Neuroscience Seminar Series for Parasitology, Advanced Concepts in Parasitology Course, Canberra, ACT Supervisor: ACT WEx (Work Experience) Dr Guowen Duan Progam Organizing Committee Member: 2014 Editorial Board Member: AIMS-Molecular Australian Society for Parasitology Supervisor: ANUMS MChD Student Science, SM Vaccines and Meeting, Canberra, ACT Research Program Vaccination Journal Organizing Committee Member: 2015 Invited Editor: Special issue - The role Associate Professor Marco Australasian Society for Immunology of non-coding RNAs in autoimmunity Meeting, Canberra, ACT diseases, AIMS-Molecular Science G Casarotto Reviewer: International Journal of Presenter and Host: JCSMR Outreach Professor Matthew Cook Molecular Sciences Program, Canberra, ACT Member: Royal Australasian College of Reviewer: Journal of Vascular Research Member and Accounts Signatory: Physicians Research Committee Reviewer: International Journal of Australian Society for Biochemistry and Member: NHMRC Grant review panel - Biological Sciences Molecular Biology (ASBMB) Translation Faculty Committee Member: Australian Society for Medical Examiner: Royal College of Pathologists Research (ASMR) of Australasia (Immunopathology) Member: Australian Biophysics Editorial Board Member: Clinical and Society (ABS) Translational Immunology
78 The John Curtin School of Medical Research Professor Angela F Dulhunty Board Member: EMBL Australia Council Professor Christopher C Member: National Committee for Grant Reviewer: Australian Research Goodnow Biomedical Sciences Council, The Wellcome Trust, The Australian Cancer Council, The Medical Member: Australian Academy of Science Member ARC College Research Council (UK), The Queensland Special Elections Committee Organiser: Curtin Conference on Muscle, Cancer Fund, The NIH, The Swiss Member: Wellcome Trust Peer Review Canberra, ACT National Grants System, The National College, The Wellcome Trust, UK Heart Foundation (Australia), The Member: Australian Physiological Society Editorial Board Member: Immunity, Canadian Health Institutes of Research The Journal of Experimental Medicine, Member: Biophysical Society USA Reviewer: Annals of Human Genetics, Mammalian Genome, Journal of Editorial Board Member: Calcium Binding American Journal of Human Genetics, Autoimmunity, BMC Biology Proteins, Ion Channels, Genetic Epidemiology, Parasitology Today, Council Member: EMBL Australia The Biochemical Journal International Parasitology, Mammalian Vice-President: Australasian Society Grant Assessor: ARC AusReader, Genome, Nature, Nature Medicine, PLoS, for Immunology NHMRC, European, USA and NZ PNAS, Research Genetics Granting agencies Member: American Association for the Dr Suzanne Fowler Advancement of Science Member: American Association Dr Julia Ellyard Member: Australian and New Zealand of Immunologists Presenter and Participant: JCSMR Laboratory Animal Association Open Day Member: Veterinary Surgeons Board Professor Jill Gready Presenter and Host: National Youth Conference Organiser: Australian Science Forum, JSCMR, ANU, and New Zealand Laboratory Animal Presenter and Participant: JCSMR Canberra, ACT Association Annual Conference Open Day Member: Australasian Society Editorial Board Member: Bioinformatics for Immunology Ms Cathy Gillespie and Biology Insights Member: ANU Supercomputing Time Judge: Australian Society for Medical Workshop Host: Bio-Medical Imaging Allocation Committee Research New Investigator Forum, students, Research School of Canberra, ACT Engineering, ANU, Molecular and cell Fellow: Royal Australian Chemical Institute Member: Australasian Society biology students, UC, Biol3190 Member: Australian Society for for Immunology. students, ANU Biochemistry and Molecular Biology th Organizing Committee Member: 45 Member: Australian Society for Biophysics Annual Meeting of the Australasian Ms Dianne Gooding Society for Immunology, 2015 Presenter and Participant: First Canberra Canberra, ACT President: Australian and New Zealand Ecuadorian Festival, Acton, ACT Laboratory Animal Association Media Interview: Good Food, The Dr Anselm Enders Conference Organiser: Australian Canberra Times: Lost crops of the Incas and New Zealand Laboratory Animal ACT Councilor: Australasian Society Association Annual Conference of Immunology Dr Rebecca Haddock Organizing Committee Chair: 45th Annual Member: JCSMR Gender Meeting of the Australasian Society for Equity Committee Immunology, 2015, Canberra, ACT Member: NHMRC Early Career Co-Chair: Organizing committee for joint Fellowships Panel Workshop - Australasian Society for Member: Postgraduate Scholarship and Immunology and the German Society for Awards Committee, JCSMR and ANU Immunology, 2015, Canberra, ACT Medical School Vice-President: Australia & New Zealand Professor Simon Foote Microcirculation Society Member: NHMRC Research Committee Member: Australasian Society of Clinical & Experimental Pharmacologists Scientific Advisory Board Member: and Toxicologists Ramaciotti Foundation Member: High Blood Pressure Research Chair: NHMRC Project Grant Council of Australia Review Panel Member: National Association of Board Member: Royal Hobart Research Fellows Hospital Foundation Member: American Heart Association
Annual Review 2014 79 Ms Angela Higgins Dr Ben Kaehler Dr Peter Milburn Presenter and Participant: JCSMR Member: Genetics Society of Australasia Member: The Association of Biomolecular Open Day Member: Statistics Society of Australia Resource Facilities (ABRF) USA
Dr Kesisuke Horikawa Associate Professor Guna Ms Lorena Nunez Villacis Member: Australasian Society Karupiah Presenter and Participant: First Canberra for Immunology Ecuadorian Festival, Acton, ACT Vice-President: Federation of Immunological Societies of Asia-Oceania Presenter and Participant: JCSMR Ms Helena Huang Open Day Member: American Association Presenter and Participant: JCSMR Open of Immunologists Day, The John Curtin School of Medical Ms Stephanie Palmer Member: American Society Research, ANU, Canberra, ACT for Microbiology Presenter and Participant: JCSMR Presenter and Participant: National Youth Outreach Program - ANU BIOL3190 Member: American Society Virology Science Forum, JCSMR, ANU, Science in the Workplace and ANU Canberra, ACT Member: Australasian Society BIOL8702 Masters of Biotechnology, for Immunology Member: Australasian Advanced Research Techniques Neuroscience Society Presenter and Participant: JCSMR Member: Society for Neuroscience (USA) Dr Yalin Liao Open Day ACT Branch Committee Member: Member: The Australasian Genomics Associate Professor Gavin Nutrition Society of Australia Technologies Association (AGTA) Huttley Volunteer: Scientist and Mathematicians in School Professor Christopher R Reviewer: Molecular Biology and Volunteer: Amaroo School, Canberra, Parish Evolution; Systematic Biology ACT: Healthy dietary habits - Founding Member: World AllergoOncology Editorial Board Membership: Frontiers in Rainbow eating Evolutionary and Population Genetics, Task Force (Vienna-based) Biology Direct, PLoS ONE Canberra 2014 Citizen of the Year Professor Ted Maddess Reviewer: ARC, NHMRC Member: NHMRC Assigners Academy Member: Genetics Society of Australasia, Dr Ian Parish Section Editor: Clinical and International Society for Molecular Biology Member: Australasian Society for Experimental Ophthalmology and Evolution Immunology Member: Board of Administration: Organizing Committee Member: 45th National Vision Research Institute, Mr Cameron Jack Annual Meeting of the Australasian Melbourne, VIC Member: The Australasian Genomics Society for Immunology, 2015, Member: Board of Directors: Australian Technologies Association (AGTA) Canberra, ACT Council of Optometry, Melbourne, VIC Presenter and Participant: JCSMR News and Commentary Editor: Consultant: NIH Grants Outreach Program - ANU BIOL3190 Immunology and Cell Biology Science in the Workplace ANU Founder: nuCoria Pty Ltd Member: Scientific Review Committee Presenter and Participant: JCSMR Presenter and Participant: JCSMR Clinical for Canberra Health Annual Research Open Day Suite Open Day Meeting (CHARM) 2014 Presenter and Participant: JCSMR Mr Yogesh Jeelall Open Day Coordinator: ASMR ACT School Quiz Dr Claudio Mastronardi Chair: ComBio2014 Signalling Colloquium Member: International Society for Neuro- Co-organiser: Australasian Society for Immuno-Modulation (ISNIM) Immunology ACT-NSW Branch Meeting Member: Society for Neuroscience USA Dr Babu Kannappan Member: The Endocrine Society Presenter and Participant: JCSMR Open Day
80 The John Curtin School of Medical Research Dr Hardip Patel Dr Jason Potas Deputy Chair: Research Committee CMBE/ANU Member: The Australasian Genomics ANS Representative: Science Technologies Association (AMATA) Technology Australia NHMRC Panel Member: GRP2a Member: Genetics Society of Australasia ACT Council Representative: Australasian Grant-Assessor for ARC, National Heart Neuroscience Society Foundation, Clive and Vera Ramaciotti Facilitator: Weekly drop-in sessions Foundation, Sylvia and Charles Viertel Workshop Presentation: Genome ANU Representative: Australian Medical Foundation, Marsden Fund (NZ), Swiss Sequencing and Annotation: Data Schools Assessment National Science Foundation, Austrian Management, at CBA Workshop, Collaboration (AMSAC) Science Fund (FWF), Cancer Research Canberra, ACT Finalist: Your science in 60 seconds, UK, NSF (USA), French National Research Agency (ANR), and European Workshop Presentation: GVL-Galaxy Science Meets Parliament Research Council workshop, Genetics Society of AustralAsia PhD Thesis Examiner: University of Sydney CAP committee/ (PhD) thesis examiner: Annual Meeting, Sydney, NSW Member: Brazil Regional Reference UNSW, University of Sydney, University of Group (ANU) Newcastle, UQ, UWA Dr Gilberto Paz-Filho Participant: Scientists in Schools participant Editorial Board Member: PLoS ONE Editorial Board Member: Brazilian Archives Australasian Neuroscience Society delegate: Editorial Board Member: FEBS Open Bio of Endocrinology and Metabolism Science meets Parliament Reviewer: Cell, Science, Nat Cell Biol, Member: Latin American Thyroid Society Australasian Neuroscience Society delegate: PLoS Biol, EMBO J, TIBS, Genome Biol, Science Technology Australia Member: Brazilian Society of Endocrinology NAR, RNA and Metabolism ANU Representative: Australian Medical Co-convenor, Session Chair and Speaker: Schools Assessment Member: The Endocrine Society EMBL Australia PhD Course, Collaboration (AMSAC) Committee Member: The Endocrine Canberra, ACT Interviewer: ANU Medical Society’s Minority Affairs Committee Organising committee member: 1st Joint School Admissions Committee Member: The Endocrine Australia Japan RNA Meeting, Society’s Awards Review Committee Exam Committee member: Year 1 and Year Sydney, NSW 2, ANU Medical School External Assessor: National Health and Programme Co-chair: ComBio 2014, Medical Research Council Project Grants Committee member: JCSMR Group Canberra, ACT Leaders Forum Member: Editorial Board of Translational Gastrointestinal Cancer Committee Member: Medical Science Ms Anne Prins Theme, ANU Medical School Member: The Australian National University Presenter and Participant: National Youth Human Research Ethics Committee Year 1 exam committee member: ANU Science Forum, JCSMR, ANU, Medical School Guest Editor: Special issue of Translational Canberra, ACT Gastrointestinal Cancer: Interactions Presenter and Participant: JCSMR between the Endocrine System and the Professor Thomas Preiss Open Day Gastrointestinal Tract Member: Australian Society for Presenter and Organiser: Surgical Cut Up Biochemistry and Molecular Biology Workshops, CIT Bruce, ACT Dr Kaiman Peng Chair: RNA network Australasia, an Invited Speaker: Heparan sulfate staining Presenter and Participant: JCSMR ASBMB SIG in Type 1 Diabetes Research Victorian Outreach Program - ANU BIOL3190 Member: Australasian Microarray & Histology Meeting, Hobart, TAS Science in the Workplace Associated Technologies Association Anatomical Pathology Demonstrator: Member: German Society for Biochemistry University of Canberra, Bruce, ACT and and Molecular Biology Canberra Institute of Technology, Bruce, ACT Member: ANU Major Equipment Committee Member ANU Regional Reference Group Europe Member Early Career Academic Development Committee CMBE/ANU (since 2014) Member: JCSMR External Relations Committee Member: JCSMR Group Leaders’ Forum
Annual Review 2014 81 Professor Jan Provis Dr Stuart Read Ms Rina Soetanto Member: Scientific Advisory of the Member: International Society of Presenter: ANU 3-Minute Thesis Ophthalmic Research Institute of Transgenic Technologies (ISTT) Competition: Mending a broken heart- a Australia (ORIA) Member: Australian Society for Medical big role for small RNAs, ANU, Member: Scientific Advisory, EyeCo Research (ASMR) Canberra, ACT Australia Pty Ltd Member: Australian New Zealand Presenter: The Science Show, ABC Radio Chair: Research Grants Advisory Group, Laboratory Animal Association (ANZLAA) National: Mending a broken heart- a big role for small RNAs Retina Australia Session Chair: Asian Mouse Phenotyping Associate Dean: Teaching & Learning, Consortium Student Workshop, Treasurer: Australian Society for Medical ANU Medical School Canberra, ACT Research (ASMR), ACT branch Sub-Dean: ANU Medical School, Organizing Committee Member: EMBL Acton Campus Dr Jennifer Robertson Australia PhD Symposium Organizing Committee Member: The John Member: Australasian Neuroscience Presenter and Participant: JCSMR Society (ANS) Curtin Association of Research Open Day Students (JARS) Member: Association for Research in Member: Australasian Vision & Ophthalmology (ARVO) Reviewer: The ANU Undergraduate Neuroscience Society Research Journal Member: Scientific Review of Progress – Presenter and Participant: ACT ClemCell Project, Bond University. Member: Australian Society for Government Women’s Day Event, The Biochemistry and Molecular Member: Bendigo Bank Scholarship John Curtin School of Medical Research, Biology (ASBMB) Advisory Group, Braidwood-Bungendore ANU, Canberra, ACT Member: The RNA Society District. These scholarships are for Presenter and Participant: UniSA students entering tertiary education and Students Visit, The John Curtin School of are in need of and eligible for Medical Research, ANU, Canberra, ACT Dr Zan-Ming Song financial support. Editorial Board Member: Scientific World Dr Charmaine Simeonovic Journal (Neuroscience Section; Open Dr Charani Ranasinghe Journal of Applied Sciences Member: Australasian Society Volunteer worker: Belconnen Art Centre for Immunology Co-Chair: Block 5 of MChD medical curriculum, ANU Medical School, The Member and Volunteer worker: AIDS Member: Transplantation Society of Action Council ACT Australian National University, Australia and New Zealand. Canberra, ACT Member: Australasian Society Member: Transplantation Society for Immunology (International). Professor Greg Stuart Member: Society for Member: International Pancreas and Islet Mucosal Immunology Transplant Association. Instructor and presenter: Australian Course in Advanced Neuroscience, North ACT Representative: ASI Mucosal Member: Immunology of Diabetes Stradbroke Island, QLD Immunology Special Interest Group Society (International) Convenor: Australian Brain Bee President: ASI Mucosal Immunology Member: International Challenge, ACT Regional Finals, JCSMR, Special Interest Group Xenotransplantation Association Canberra, ACT Member: Cell Transplantation Society Associate Editor: Frontiers in Dr Danny Rangasamy Member: Australian Diabetes Society Cellular Neuroscience Grant Assessor: NHMRC Member: Islet Society Advisory Editorial Board: Trends Editoral Board Member: Solid Tumor; in Neurosciences Biotechnology Letters Dr Tatiana Soboleva Council Member: Sydney Chapter of the Member: Australian Society for American Society of Neuroscience Visiting Scientist: Telopea Primary School, Biochemistry and Molecular Member: Australasian Barton, ACT as part of the Scientists in Biology (ASBMB) Neuroscience Society Schools program, CSIRO, Canberra, ACT Member: Australian Academy of Science Member: Society for Neuroscience (USA)
82 The John Curtin School of Medical Research Dr Norimitsu Suzuki Dr Krisztina Valter Mr Jorge Velez Demonstrator: Australian Course in Chair: ANU Medical School Foundation Reviewer: Revista Colombiana de Estadística Advanced Neuroscience, Moreton Bay Block, ANU, Canberra, ACT (Colombian Journal of Statistics), Department Research Station, North Stradbroke Chair: JCSMR Workplace Health & of Statistics, National University of Colombia Island, QLD Safety Committee at Bogotá; Revista Comunicaciones en Estadística Communications in Statistics Presenter and Participant: National Youth Founding Member: ANU Education Science Forum, JCSMR Journal); Revista DYNA (Dyna Journal), Fellowship Scheme Committee Faculty of Mines, National University of Member: Australasian Member: ANU Medical School Research Colombia at Medellín; Revista de Ingeniería Neuroscience Society Project Committee (Engineering Journal), University of Antioquia, Medellín, Colombia Member: Society for Neuroscience (USA) Member: Year 1 and Year 2 Examination Committees, ANU Medical School, ANU, Dr Rebecca Sweet Canberra, ACT Professor Carola G Vinuesa Member: Australian Society for Member: Phase 1 Curriculum Committee, Member: Australasian Society Medical Research ANU Medical School, ANU, Canberra, ACT of Immunology Member: Australasian Society Member: Medical Science Committee, ANU Member: American Association for Immunology Medical School, ANU, Canberra, ACT of Immunologists Member: The American Association Member: Neuroscience Discipline Committee, Member: NHMRC Women in Health and of Immunologists JCSMR, ANU, Canberra, ACT Science Research (WiHS) Member: Association for Research in Vision working committee Dr Malinda Tantirigama and Ophthalmology (ARVO) Scientific Advisory Board Member:S ylvia Member: European Vision and Eye and Charles Viertel Foundation Member: Australasian Research (EVER) WHO Advisor: Department of Neuroscience Society Member: International Society of Ocular Cell Reproductive Health Member: Society for Neuroscience (USA) Biology (ISOCB) Advisory Board Member: Autoimmunity Presenter and Participant: JCSMR Member: Australasian Neuroscience Center of Excellence, BIIR Center for Open Day Society (ANS) Inflammation & Genomic Medicine, Baylor Institute, Dallas, TX, USA Member: Australia and New Zealand Professor David Tremethick Association for Clinical Anatomists (ANZACA) Member: JCSMR Executive Committee Committee member: ACT branch of the Member: International Association for Medical EC Scientific AdvisoryC ouncil Member: Australian Society for Medical Research Education (AMEE) SYBILLA European Community Program ‘System Biology of T cell activation in Health ACT representative: The Australian Presenter and Participant: National Youth and Disease’ Society of Biochemistry and Science Forum, JCSMR, ANU, Molecular Biology Canberra, ACT Dr Harpreet Vohra Editorial Board Member: Chromosoma; Presenter and Participant: Indigenous student Epigenetics; Epigenetics & Chromatin; open day, ANU Medical School, ANU, Workshop and Lecture Host: Master Open Biology Canberra, ACT of Biotechnology students, ANU, Bio- Member: Lorne Genome Society Participant: Bioscience Teaching in Allied Medical Imaging students, Research School of Engineering, ANU, Immunology Member: Australian Society for Health Working Group CUBE NET students, UC, Molecular and cell biology Biochemistry & Molecular Biology Participant: Scientists and Mathematicians students, UC, Biol3190 and BIOL3144 Member: American Society in Schools students, ANU for Microbiology Presenter: Australian Cytometry Society Stream coordinator: ComBio Conference, Ms Tatiana Vassilieva Meeting, Gold Coast, QLD Canberra, ACT Presenter and Participant: JCSMR Open Day Dr Hilary Warren Audio Describer: Vision Australia
Ms Belinda Whittle Member: The Australian Genomics Technologies Association Session Chair: Asian Mouse Phenotyping Consortium Student Workshop, Canberra, ACT
Annual Review 2014 83 84 The John Curtin School of Medical Research Support to JCSMR 2014
Grant Success
Financial Overview
Donors to JCSMR
Report from The John Curtin Medical Research Foundation
Our Corporate Sponsors
Annual Review 2014 85 Grants
ACT Chief Minister - Australian Research Council Professor T Preiss Treasury and Economic Centre of Excellence Tracking factor footprints to reveal Development Directorate the intricacy and control of Professor G Stuart, Associate translation initiation Professor C Parish and Professor Professor E Arabzadeh, Professor $110,000 R Hannan M Ibbotson, Professor P Martin, Dr D Rangasamy and Professor JE Centenary Chair in Cancer Research Professor S Petrou, Professor Dahlstrom $500,000 S Skafidas, Professor M Rosa, Professor J Mattingley, Professor Understanding the role of endogenous siRNAs in the maintenance of Australian Centre for HIV PA Robinson, Professor AJ Lowery, genomic defences Professor G Paxinos, Associate and Hepatitis Virology $70,000 Professor U Grunert, Professor G Research Grant Egan, Professor P Sah Professor D Tremethick Dr A Suhrbier, Professor E Gowans, Integrative Brain Function Understanding how dynamic changes in Dr C Ranasinghe and Dr K Wagstaff $292,133 chromatin composition control genome function Validation of an effective HIV vaccine for pre-clinical evaluation Australian Research Council $182,000 $165,000 Discovery Project Grants Australian Research Council Dr C Ranasinghe and Dr A Suhrbier Associate Professor E Arabzadeh Future Fellowship EcoHIV -a convenient biosafety Level 2 Sensory integration in the whisker mouse model for animal testing of HIV pathway: cortical transformations and Associate Professor E Arabzadeh vaccines and anti-retroviral drugs the neuronal mechanisms that underlie Neuronal and behavioural correlates of $22,900 decision confidence sensory adaptation $115,000 $177,397 Australian National Dr VR Daria University Major Equipment Four-dimensional analysis of information Australian Research Council Committee Award processing in brain circuits Linkage Project $255,000 Professor J Carver, Professor G Professor T Maddess, Professor Otting, Professor D Tremethick, Dr VR Daria, Associate Professor G Stuart, Dr A James and Dr B Dr D Hall and Associate Professor C Stricker, Professor S Redman, McGrath M Casarotto Professor H Bachor and Professor Creating new methods to study Foundation of a Quantitative G Stuart structure vision Bio-molecular Interactions Analysis Facility Using light to probe brain activity in 3D $180,762 $95,000 $140,000 Bayer CropScience LP Professor S Easteal, Associate Professor A Dulhunty, Dr N Beard Professor M Arcos-Burgos and and Dr F Protasi Professor J Gready Dr C Mastronardi Calcium signalling by intracellular calcium Development of ANU technology for the Robotics to Prepare Human Samples for stores in rabbit, mouse and man: design of variant Rubisco proteins with Genome Sequencing Implications for muscle performance and improved catalytic activity $165,000 athletic ability $589,287 $145,000 Associate Professor G Huttley, Professor J Borevitz, Professor S Professor S Easteal and Professor Belgian Science Policy Office Easteal, Professor C Moritz and NG Martin InterUniversity Attraction Dr S Foret Variation in the arginine vasopressin 1a Poles Programme Grant Genome Diversity of Australia receptor gene in the social environment and health $110,000 Professor CG Vinuesa $112,000 T lymphocytes: from basic biology to immunotherapy $10,100
86 The John Curtin School of Medical Research Bioplatforms Australia Department of Industry, Ian Potter Foundation Ltd National Collaborative Innovation, Climate Associate Professor I Cockburn Research Infrastructure Change Science Research Intra-vital microscopy for research into Scheme and Tertiary Education infectious disease, cancer and autoimmunity (DIICCSRTE) National Professor D Tremethick $50,000 Collaborative Research Emerging Biomolecular Platforms and Informatics Project Infrastructure Scheme Melanoma Institute Australia
$450,000 Professor Simon Easteal Mr M Field Australian National University Major Open Virtual Genomics Laboratory Cancer Australia Data Collections Project $75,000 Dr A Blackburn and $200,000 Professor P Board Dr S Winslade MuPharma Pty Ltd Targeting of two aspects of metabolic Australian Phenomics Network (TOTAM) for cancer therapy Dr C Ranasinghe $1,325,815 Evaluation of a novel mucosal vaccine $3,560 delivery device Genentech $49,295 Commonwealth Department Dr S Winslade of Education Collaborative National Health & Medical Research Infrastructure Genentech Research Collaboration and Exclusive License Agreement Research Council Australia Scheme $1,171,000 Fellowship Dr S Winslade Professor CC Goodnow Australian Phenomics Network Grains Research and New strategies to reveal the genetic and $1,566,666 Development Corporation cellular basis of immunological disease (GRDC) $800,000 Commonwealth Department Professor J Gready of Health National Health & Medical Identification of Superior Rubiscos in Associate Professor B Lidbury Wheat Relatives and lntrogression into Research Council Career and Dr T Badrick Elite Wheat Development Fellowships $750,000 Novel quantitative methods that enhance Dr N Beard clinical decision support based on routine pathology testing Control of cardiac and skeletal Heart Foundation contractility by luminal calcium store load $53,900 Grant-in -Aid in health and disease $96,040 Department of Industry, Professor C Hill, Professor K Innovation, Climate Matthaei, P Hansen, G Drummond, Dr A Enders M Esler and B Kemp-Harper Change Science Research Investigating B cell development Treating therapy resistant hypertension: A maintenance and high-affinity antibody and Tertiary Education role for atypical gated calcium channels production by ENU mutagenesis (DIICCSRTE) Australia-India $65,000 $101,220 Strategic Research Fund Human Frontier Science National Health & Medical Professor P and Dr N Lenka Research Council Early An insertational mutagenesis approach Program to identify epigenetic factors that control Career Fellowships Dr R Sweet embryonic stem cell differentiation The role of T cell derived interferon Dr N Beveridge $82,559 gamma in lupus associated anxiety and RNA methylation and microRNA function depression in eukaryotic RNA $77,550 $76,149
Annual Review 2014 87 Dr J Reed National Health & Medical Professor PG Board, Professor AF Mechanisms of anti-Ro60 autoantibody- Research Council Dulhunty, Dr MG Casarotto and mediated tissue injury in congenital Program Grants Professor L Arnolda heart block New cardiac ryanodine receptor inhibitors $76,419 Professor R Hannan, R Hicks, RB for the treatment of heart failure Pearson and G McArthur $197,244 National Health & Medical Oncogenic signaling and cancer therapy Professor S Broer, Dr A Enders and Research Council $350,000 Associate Professor R Callaghan Equipment Grants Professor C MacKay, Professor J Phospholipid dependent signaling in B-cells Dr M Casarotto Sprent, Professor CC Goodnow, $146,725 Dr F MacKay, Professor CG Vinuesa, Wyatt QELS-Quasi-Elastic Light Associate Professor M Casarotto, Scattering Accessory Professor A Basten, Professor B Professor J Dahlstrom, Fazekas de St Groth, Dr S Tangye and $32,240 Professor A Oakley and Dr S Rao Dr R Brink Epigenetic regulation by lysine specific Dr A Enders Molecular and cellular studies of the demethylases in human breast cancer 561nm yellow green laser for flow cytometry adaptive immune response in health stem cells $31,000 and disease $22,881 $1,086,841 Professor D Tremethick Professor M Cook, Dr D Tscharke, Professor C Parish, Professor B QuantStudio 3D Digital PCR System Professor C Goodnow and Chong, Professor LM Khachigian and $37,199 Dr D Fulcher Professor R Stocker Genomic medicine for human Novel Mechanisms Molecular Targets and National Health & Medical immune deficiency therapies in Cardiovascular Disease Research Council Postdoctoral $167,123 $386,682 Training Fellowships Professor AF Dulhunty, Dr J Ellyard National Health & Medical Professor L Arnolda, The effect of follicular helper T cells on Research Council Project Dr A Blackburn and Dr N Beard AID regulation and selection of high Grants Anthracyclines disrupt Ca2+ signalling in affinity germinal centre B cells cardiomyocytes: a contribution to cardiac toxicity $20,375 Associate Professor E Arabzadeh Neuronal Substrate of Choice in the Rat $148,775 Dr I Parish Whisker System Professor AF Dulhunty, Regulation of CD8+ T cell dysfunction $128,094 during tolerance and chronic viral infection Dr MG Casarotto and $77,718 Professor JM Bekkers and Professor PG Board Dr Mark McDonnell DHPR β subunit binding to a variably spliced region of RyR1: A role in EC National Health & Medical Persistent firing in cortical interneurons: mechanisms and potential anticonvulsant coupling and myotonic dystrophy Research Council role $178,902 Postgraduate Scholarship $144,302 Professor AF Dulhunty, Dr MG Dr S Jiang Professor PG Board Casarotto, Professor PG Board The effect of single nucleotide Glutathione transferase Zeta: A novel and Professor A Oakley polymorphisms on immune regulation regulator of glucose and lipid metabolism Interaction between the alpha and beta and the development of systematic lupus $196,084 subunits of the DHPR- a missing link in erythematosus skeletal muscle excitation contraction $48,956 Professor P Board, Dr A Blackburn coupling and a role in sarcopenia and Professor J Dahlstrom $222,475 Prevention of drug toxicities with dichloroacetic acid - the implication for cancer chemotherapy $186,332
88 The John Curtin School of Medical Research Professor S Easteal, Dr N Cherbuin, Professor T Preiss and modes of IL-3 receptor activation and Professor M Arcos-Burgos and Professor M Hentze investigation of new receptor-associated signalling partners Associate Professor G Huttley Charting the interface between cellular Haplotype variation at the dopamine metabolic states and gene regulation $199,895 transporter gene [SLC6A3]: function $210,217 endophenotypes cognition and ADHD National Health & Medical $198,336 Dr C Simeonovic and Research Council Research Professor S Bornstein Fellowships Dr K Horikawa Impact of islet beta cell heparan sulfate in Antigen receptor as oncogene: Type 2 diabetes Professor C Vinuesa Understanding CARD11 mutations in B $148,636 cell malignancy $132,903 $195,801 Dr C Simeonovic, Professor C Parish and Professor S Bornstein National Institutes of Health Associate Professor G Huttley and Mechanism of protection of islet beta cells (US) Project Grants Dr W Meyer from T1D by heparan sulphate Professor C Goodnow, Associate Uncovering the genetic basis of fungal $198,678 virulence Professor G Karupiah, Dr E $82,893 Professor GJ Stuart Bertram and Professor R Ulevitch Impact of inhibition on brain function Systems approach to immunity Professor J Licinio, Professor $203,732 and inflammation M Arcos-Burgos, Associate $802,954 (in conjunction with The Professor G Huttley, Professor Professor DJ Tremethick Scripps Research Institute) S Easteal, Professor B Raphael, How our genome is regulated to Professor NG Martin and Professor determine cell function Professor C Goodnow, Professor R Ulevitch and Professor B Beutler M-L Wong $216,864 Genetic variants and environmental Core A: Genetics factors in depression Professor DJ Tremethick $630,442 (in conjunction with The $141,498 A new function for histone variants in the Scripps Research Institute) tissue-specific regulation of Professor JP Mackay and Dr D Ryan pre-mRNA splicing Professor C Goodnow, Professor R Structural and functional analysis of a $211,864 Ulevitch and Professor B Beutler cancer-linked co-regulator complex Systems approach to immunity and Dr K Valter- Kocsi, Professor J inflammation - Annotation $15,000 Provis, Professor P Gatenby and Dr $128,418 (in conjunction with The Professor T Maddess, Dr F Sabeti, M Madigan Scripps Research Institute) Dr C Carle, Associate Professor Fighting age-related macular AC James, Professor J Provis and degeneration by reducing Professor T Lamb Dr R Essex inflammatory events Short-term adaptations in photoreceptors Novel functional testing for $170,695 $44,280 macular degeneration Professor CG Vinuesa and $170,854 Dr J Ellyard Perpetual Trustees Australia Professor T Preiss Novel pathways that regulate T cells Associate Professor Ian Characterising the topology and function $208,742 Cockburn of the human m5C RNA methylome Development and testing of a chemically Professor I Young and $206,056 attenuated whole parasite malaria vaccine Professor P Foster $100,000 Professor T Preiss and Targeting miRNA to inhibit leukocyte Dr J Clancy differentiation: a novel anti-inflammatory approach for the treatment of asthma Vasculitis Foundation Exploring the role of miRNA and $96,835 target processing variability in Professor C Vinuesa and cardiac hypertrophy Professor I Young, Professor D Ollis Dr G Walters $194,895 and Dr J Murphy The role of microRNA in a novel mouse Cytokine-driven allergic inflammation: model of vasculitis characterization of two isoform-specific $50,000
Annual Review 2014 89 Financial Overview
Staff numbers 2013 2014 Academic staff * 75.1 72.75 General staff — administration, technical & support *º 140.45 139.44 HDR students (EFTSL) 81.0 73.56 Postgraduate coursework students (EFTSL) 11.1 8.38 Undergraduate Students 23.9 22.38
* The figures are for Full Time Equivalents, as at 31 December, and exclude casuals º Includes Animal Service Facility staff Recurrent and Special Purpose Funds $ Total Income 2013 2014 Student Fees 464,760 319,380 Other Income 23,595,143 20,649,445 Internal Sales 3,986,467 4,409,951 Transfer from other 6,419,273 1,514,428 Internal Allocations 2,495,286 2,854,129 Operating Grant 17,930,737 17,330,125 Investment Income 59,501 332,507 To t a l Income 54,951,167 47,409,964
Total Expenditure Salaries & Related Costs 24,999,564 25,149,425 Equipment - Capital 4,309,383 2,497,909 Equipment - Non-Capital 533,048 491,920 Scholars Expenses 902,531 804,195 Utilities & Maintenance 2,766,480 2,895,152 Travel Field & Survey Expenses 789,586 700,655 Expendable Research Materials 8,788,626 8,036,658 Other Expenses 8,238,979 5,816,066 Transfer to other 7,661,040 4,369,186 Total Expenditure 58,989,238 50,761,167
Net Current Year Operating Result 4,038, 070 3,351,203 Prior Year Cash Result 21,225,223 17,683,730 Net Operating Position 17,187,153 14,332,528
90 The John Curtin School of Medical Research DONORS to The John Curtin School of Medical Research
The Director, staff and students of The Estate of the Late Ms Dulys Mr Robert Schutz JCSMR thank all those friends and Anscombe Mrs Diana Scudamore donors who so generously supported our Mr Stephen Barrett work during 2014. Mr Dominic Staun Bowfate Pty Ltd Their Gifts and bequests to the School Mrs Helene Stead are being used to fund vital medical Mr Mark Bruce Miss Tracey Stevenson research projects as well as providing Canberra Medical Society Ms Sue Sullivan scholarships and purchasing specialised Club Jervis Bay equipment. The Sarah-Grace Sarcoma Foundation Ms Joanne Donnelly If you would like to support our research, Mr Robert Tupper please consider a gift or bequest to fund Miss Rachel Feeney Mr Thomas and Mrs Jenny Tyrrell a particular research project, scholarship Mrs Gwenyth Hallows or prize. Ms Debbie Vipond Dr Kevin Harding If you would like to discuss options for The Estate of the Late Dr Gwendolyn supporting JCSMR, please contact: Mrs Bev Harvey Woodroofe Dr Madeleine Nicol Mr Kieren Harvey Mr Robin Yule T 02 6125 2577 Mrs Marie Hotchkiss E [email protected] John James Foundation Mrs Robyn Jones Mrs Yvonne Keen Mr Michael King Mrs Thelma Maurice Ms Jennifer McEniery Ms Heather McLoughlin Mrs Annmarie McQuarrie Mrs Frances and Mr James Mifsud Mr John Nagle Mr Kevin Nguyen Mrs Rhonda Robinson Mr Gordon and Mrs Barbara Rogers Rotary Club of Goulburn, Mulwaree Sarcoidosis Australia
Annual Review 2014 91 The John Curtin Medical Research Foundation – Report to Donors 2014
Our thanks go to those who have so School of Medical Research. The Donors to The John generously supported The John Curtin Foundation played a very significant role Medical Research Foundation at ANU in achieving $1.5M in support from the Curtin Medical Research during 2014 ACT Government to partner with ANU in Foundation 2014 this appointment. Dr Mohammed Alsalami AM In February 2014 the National Centre Mr Michael Calkovics for Indigenous Genomics was launched 2014 was a very successful year for at JCSMR. The Canberra Medical Dr Kee Cheung OAM The John Curtin Medical Research Society, which has been involved in Mrs Connie Clancy Foundation, with many goals achieved. Indigenous health projects for over a Mr Bob Cotton The highlight of the year was our second decade, donated $34,000 to support Annual Dinner, at which Nobel Laureate the NCIG and their important work. The The Tom Efkarpidis Foundation Professor Robin Warren was our special CMS, in conjunction with JCMRF will Ms Rosmery Franco guest. Nearly 200 attendees heard host “Sunday Dreaming” on the grounds Professor discuss the science that led of Government House in May 2015, in Mr Denis Gilmour to his and Professor Barry Marshall’s order to raise further funds and increase Ms Wendy Gray discovery of the Helicobacter pylori as the awareness about the work of the NCIG. Mr Paul Greenhalgh AM cause of peptic ulcers. The Foundation has greatly enjoyed Ms Mary Humphries The 2nd Annual Dinner also saw the engaging with all those donors who have Foundation achieve its goal of purchasing supported our projects, and medical Mr David Hunt a $1.2M intra-vital microscope for The research at ANU throughout 2014. John James Foundation John Curtin School of Medical Research, I would like to thank each of those donors Mr David Kennemore thanks to generous donations on the on behalf of the Board for their passion night from The John James Foundation, for life changing medical research, and Mr Paul Kitney and Janice and Ron Parker. The Board their generosity. Dr Lachlan Lewis is very grateful for all the donations it has received over the past two years Dr Cameron Webber OAM Professor Masayuki Miyasaka culminating in this purchase. Chair – The John Curtin Medical Mr Ron and Mrs Janice Parker Research Foundation We were also able to produce three Mr Brian and Mrs Margaret Parry high quality newsletters throughout Mr Graham and Mrs Gail Potts 2014, which highlighted the excellence of medical research at ANU. I would For further information please see: Mr Gary and Mrs Marianne Robb jcmrf.anu.edu.au particularly like to thank Ken Begg, Dr Mr Bert Roberts Peter Jeffrey and Dr Madeleine Nicol for their superb efforts in producing the Mrs Helen Todd newsletter, which was very favorably Dr Fred Tosolini received by the public at large. Mr Tony and Mrs Lorna Ward Another 2014 highlight for the Mrs Ilona White Foundation was the announcement that Professor Ross Hannan had been Mr George Wyer appointed as the first Centenary Chair Mrs Margaret Yeung of Cancer Research at The John Curtin
The Board would also like to thank Mr Rodney and Mrs Michele Black Ms Donna Gibbons all those who volunteered their time Boffins Restaurant, University House Home by Creations Manuka and expertise, provided prizes for our fundraising events, and supported the The Brassey Hotel Ms Gina Jeffrey Foundation throughout 2014. Burbury Terrace, The Burberry Hotel and Malamay Apartments Mania Manuka Bunnamagoo Wines, Mudgee Marshall Surf Design Ms Helen Aitken-Kuhnen Capital Eye Ms Lynne Mills Mr Martin and Mrs Susie Beaver – The Creations Jewellers Manuka Mont Adventure Equipment Beaver Galleries Ms Marilyn Fenner Ms Rhonda Robinson Bilk Gallery Focus on Eyewear Mrs Joanna Webber
92 The John Curtin School of Medical Research Corporate sponsors
The John Curtin School of Medical Research ANU College of Medicine, Biology and Environment 131 Garran Road Acton ACT 2601 Australia T +61 2 6125 2550 F +61 2 6125 2337 E [email protected] W jcsmr.anu.edu.au CRICOS #00120C M O _140180