Miscarriage in Early Pregnancy
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Physiology of Female Sexual Function and Dysfunction
International Journal of Impotence Research (2005) 17, S44–S51 & 2005 Nature Publishing Group All rights reserved 0955-9930/05 $30.00 www.nature.com/ijir Physiology of female sexual function and dysfunction JR Berman1* 1Director Female Urology and Female Sexual Medicine, Rodeo Drive Women’s Health Center, Beverly Hills, California, USA Female sexual dysfunction is age-related, progressive, and highly prevalent, affecting 30–50% of American women. While there are emotional and relational elements to female sexual function and response, female sexual dysfunction can occur secondary to medical problems and have an organic basis. This paper addresses anatomy and physiology of normal female sexual function as well as the pathophysiology of female sexual dysfunction. Although the female sexual response is inherently difficult to evaluate in the clinical setting, a variety of instruments have been developed for assessing subjective measures of sexual arousal and function. Objective measurements used in conjunction with the subjective assessment help diagnose potential physiologic/organic abnormal- ities. Therapeutic options for the treatment of female sexual dysfunction, including hormonal, and pharmacological, are also addressed. International Journal of Impotence Research (2005) 17, S44–S51. doi:10.1038/sj.ijir.3901428 Keywords: female sexual dysfunction; anatomy; physiology; pathophysiology; evaluation; treatment Incidence of female sexual dysfunction updated the definitions and classifications based upon current research and clinical practice. -
Case-Scenario-10-FINAL.Pdf
Case scenario 10 – Magdalena Part 1 • Magdalena is 26 years old. She is 13 weeks pregnant and had a high chance combined test result of 1 in 140 for trisomy 13 with an NT measurement of 2.4mm. • After a lengthy discussion about her options, she decided to have NIPT. • The results reported a greater than 60% chance of the baby having Patau’s syndrome. She decided to have an invasive test. A CVS was performed. Would you have offered a CVS to this patient? a) No - she should be offered an amniocentesis only, due to the chance of placental factors affecting a result. b) Yes - the patient should be informed of risks and benefits of both CVS and amniocentesis. Answer b) Yes - the patient should be informed of the risks and benefits of a CVS and amniocentesis. Additional note A patient/couple should be informed of the options of both forms of diagnostic procedures. They should be informed of the benefits and limitations of each test, this should include timing of testing, possible results and risks of miscarriage. This discussion should also include the couples ethical, religious, social and individual beliefs. Name the type of mosaicism that can cause a false-positive result with NIPT. a) Feto-placental mosaicism b) Placental mosaicism c) Fetal mosaicism Answer b) Placental mosaicism Additional note There is a discrepancy of the cell line in the placenta and baby. The abnormal cell lines are seen in the placenta and not on the fetus. There is a small chance that a 'high chance report is caused by 'placental mosaicism', therefore a CVS may also report 'mosaicism’. -
Masturbation
MASTURBATION Curriculum for Excellence Links to health and wellbeing outcomes for Relationships, Sexual Health and Parenthood I am aware of my growing body and I am learning the correct names for its different parts and how they work. HWB 0-47b HWB 1-47b I understand my own body's uniqueness, my developing sexuality, and that of others. HWB 3-47a HWB 4-47a Introduction Masturbation can seem a daunting subject to teach, but it is very important for young people to learn about appropriate touch. School provides an ideal learning environment for this, alongside an opportunity to work alongside parents to tackle this issue. If young people do not learn about masturbation and appropriate touch when they are teenagers, they are in danger of displaying inappropriate behaviour as an adult, often in public, which can lead to more serious repercussions. Staff may worry that teaching about masturbation can provoke a sudden obsession with genitalia, but this is usually a temporary reaction and one which can be successfully dealt with by one-to-one work through Social Stories. Having a policy on Managing Sexualised Behaviour may also be beneficial, outlining an approach to inappropriate touching in the classroom. TOUCHING OURSELVES You will need 2 body outlines/ Bodyboards (male and female). Recap on names of Parts Of The Body. Ask the students which are PRIVATE BODY parts (those covered by underwear- breasts, penis, vagina, anus, clitoris etc.) Tell the group ‘’these are Private Body Parts, not for everyone to touch and see. But sometimes people like to touch their own private body parts to make themselves feel nice and sexy. -
Survivors of Acute Leukemia Are Less Likely to Have Liveborn Infants Than Are Their
CHILDHOOD CANCER SURVIVOR STUDY ANALYSIS PROPOSAL STUDY TITLE: Fertility Rates in Long-Term Survivors of Acute Lymphoblastic Leukemia WORKING GROUP AND INVESTIGATORS: Name Telephone Number E-mail Daniel M. Green, M.D. 901-595-5915 [email protected] Vikki Nolan, Ph.D. 901-595-6078 [email protected] Liang Zhu, Ph.D. 901-595-5240 [email protected] Marilyn Stovall, Ph.D. 713-792-3240 [email protected] Sarah Donaldson, M.D. 650-723-6195 [email protected] Les Robison, Ph.D. 901-595-5817 [email protected] Chuck Sklar, M.D. 212-717-3239 [email protected] BACKGROUND AND RATIONALE: Survivors of acute leukemia are less likely to have liveborn infants than are their female siblings (relative risk (RR) =0.63, 95% confidence interval (CI) 0.52 to 0.76). The risk of miscarriage was increased among Childhood Cancer Survivor Study (CCSS) female participants who received craniospinal (RR=2.22, 95% CI 1.36 to 3.64) or cranial irradiation (RR=1.40, 95% CI 1.02 to 1.94). The risk of miscarriage was increased in survivors of acute lymphoblastic leukemia (ALL) (RR=1.60, 95% CI 0.85 to 3.00) and central nervous system tumors (RR=1.33, 95% CI 0.61 to 2.93) although neither risk achieved statistical significance 1. Winther et al. reported that the risk of spontaneous 2 abortion was not increased in survivors of leukemia compared to their sisters (proportion ratio (PR) 1.2, 95% CI 0.7 to 2.0). However those female survivors who received low doses of radiation to the uterus and ovaries, but high doses of radiation to the pituitary had an increased risk of spontaneous abortion (PR 1.8, 95% CI 1.1 to 3.0). -
Role of Maternal Age and Pregnancy History in Risk of Miscarriage
RESEARCH Role of maternal age and pregnancy history in risk of BMJ: first published as 10.1136/bmj.l869 on 20 March 2019. Downloaded from miscarriage: prospective register based study Maria C Magnus,1,2,3 Allen J Wilcox,1,4 Nils-Halvdan Morken,1,5,6 Clarice R Weinberg,7 Siri E Håberg1 1Centre for Fertility and Health, ABSTRACT Miscarriage and other pregnancy complications might Norwegian Institute of Public OBJECTIVES share underlying causes, which could be biological Health, PO Box 222 Skøyen, To estimate the burden of miscarriage in the conditions or unmeasured common risk factors. N-0213 Oslo, Norway Norwegian population and to evaluate the 2MRC Integrative Epidemiology associations with maternal age and pregnancy history. Unit at the University of Bristol, Introduction Bristol, UK DESIGN 3 Miscarriage is a common outcome of pregnancy, Department of Population Prospective register based study. Health Sciences, Bristol Medical with most studies reporting 12% to 15% loss among School, Bristol, UK SETTING recognised pregnancies by 20 weeks of gestation.1-4 4Epidemiology Branch, National Medical Birth Register of Norway, the Norwegian Quantifying the full burden of miscarriage is Institute of Environmental Patient Register, and the induced abortion register. challenging because rates of pregnancy loss are Health Sciences, Durham, NC, USA PARTICIPANTS high around the time that pregnancies are clinically 5Department of Clinical Science, All Norwegian women that were pregnant between recognised. As a result, the total rate of recognised University of Bergen, Bergen, 2009-13. loss is sensitive to how early women recognise their Norway pregnancies. There are also differences across countries 6 MAIN OUTCOME MEASURE Department of Obstetrics and studies in distinguishing between miscarriage and and Gynecology, Haukeland Risk of miscarriage according to the woman’s age and University Hospital, Bergen, pregnancy history estimated by logistic regression. -
Practice Guidelines for Molecular Diagnosis of Fragile X Syndrome
Practice Guidelines for Molecular Diagnosis of Fragile X Syndrome Prepared and edited by James Macpherson 1 and Abid Sharif 2 following a CMGS Workshop held on 10 th July 2012. 1. Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, Wiltshire, SP2 8BJ, U.K. 2. East Midlands Regional Molecular Genetics Service, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, NG5 1PB, U.K. Guidelines updated by the Association for Clinical Genetic Science (formally Clinical Molecular Genetics Society and Association of Clinical Cytogenetics) approved November 2014. 1. NOMENCLATURE and GENE IDs OMIM Condition Gene name Gene map locus 309550 Fragile X Syndrome FMR1 Xq27.3 309548 FRAXE FMR2 Xq28 2. DESCRIPTION OF DISEASE 2.1 Fragile X Syndrome Fragile X Syndrome is thought to be the commonest single-gene cause of learning disability features in humans with an estimated prevalence of 1 in 4000- 1 in 6000 males, where it causes moderate to severe intellectual and social impairment together with syndromic features including large ears and head, long face and macroorchidism 1. A fragile site (FRAXA) is expressible at the gene locus at Xq27.3, typically in 2-40 % of blood cells in affected males. The pathogenic mutation in most cases is a large expansion (‘full mutation’) in a CGG repeat tract in the first untranslated exon of the gene FMR1, which normally encodes the RNA-binding protein FMRP. Full mutations (from approximately 200 repeats upwards) result in hypermethylation of the DNA in and around the CGG tract, curtailed gene expression and no FMRP being produced 2-4. Smaller expansions of the CGG repeat, or ‘premutations’ are not hypermethylated and hence do not cause Fragile X syndrome, but may show expansion into full mutations over one or more generations. -
ART and Miscarriage Risk Assoc
27-28 January, Sofia, Bulgaria ART and miscarriage risk Assoc. Prof. Petya Andreeva, MD, PhD D-r Shterev Hospital Dr. Shterev Sofia, BULGARIA HOSPITAL Dr. Shterev Miscarriage rate HOSPITAL 10 % to 15 % of clinical pregnancies have resulted in miscarriage. 1-2% miscarriages / per couples who try to conceive. (Macklon NS et al, 2002; Rai R et al 2006) Dr. Shterev Monthly fecundity rate (MFR) HOSPITAL In humans even in optimal circumstances – clinical recognized pregnancy in one cycle or the so called monthly fecundity rate is around 30 % . In contrast MFR is 80% in baboons and 90% in rabbits. (Chard T, 1991; . Foote RH 1988; Stevens VC 1997) Dr. Shterev Ongoing pregnancy rate HOSPITAL Assisted reproductive technologies (ART) represent average 30 % pregnancy rate. Around 50% of human conception fails implantation. Up to half of implanted embryos fail to progress in ongoing pregnancy. (Macklon N 2002; Macklon N 2014) Dr. Shterev Conception to ongoing pregnancy HOSPITAL Live births -True incidence of pregnancy loss is 30% closer to 50%. Miscarriage - This renders miscarriage as the 40-50% 10 % most common complication of pregnancy Early pregnancy loss 30 % Implantation failure 30 % CONCEPTION Macklon et al, Hum Reproduction Update, 2002 Dr. Shterev Known reasons for miscarriage HOSPITAL Antiphospholipid syndrome Endocrine abnormalities Thyroid dysfunction Diabetes Chromosome aberrations Uterine structural malformation Trombophilias Unknown factors in 50 % of cases. Dr. Shterev Embryo HOSPITAL The enormous rate of early pregnancy loss in humans thought to be as a consequences of two key features of human embryos: 1. High prevalence of chromosomal abnormalities. 2. Invasiveness. Dr. Shterev HOSPITAL -Good-quality cleavage-stage embryos exhibit high rates of aneuploidy. -
The Mythical G-Spot: Past, Present and Future by Dr
Global Journal of Medical research: E Gynecology and Obstetrics Volume 14 Issue 2 Version 1.0 Year 2014 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Inc. (USA) Online ISSN: 2249-4618 & Print ISSN: 0975-5888 The Mythical G-Spot: Past, Present and Future By Dr. Franklin J. Espitia De La Hoz & Dra. Lilian Orozco Santiago Universidad Militar Nueva Granada, Colombia Summary- The so-called point Gräfenberg popularly known as "G-spot" corresponds to a vaginal area 1-2 cm wide, behind the pubis in intimate relationship with the anterior vaginal wall and around the urethra (complex clitoral) that when the woman is aroused becomes more sensitive than the rest of the vagina. Some women report that it is an erogenous area which, once stimulated, can lead to strong sexual arousal, intense orgasms and female ejaculation. Although the G-spot has been studied since the 40s, disagreement persists regarding the translation, localization and its existence as a distinct structure. Objective: Understand the operation and establish the anatomical points where the point G from embryology to adulthood. Methodology: A literature search in the electronic databases PubMed, Ovid, Elsevier, Interscience, EBSCO, Scopus, SciELO was performed. Results: descriptive articles and observational studies were reviewed which showed a significant number of patients. Conclusion: Sexual pleasure is a right we all have, and women must find a way to feel or experience orgasm as a possible experience of their sexuality, which necessitates effective stimulation. Keywords: G Spot; vaginal anatomy; clitoris; skene’s glands. GJMR-E Classification : NLMC Code: WP 250 TheMythicalG-SpotPastPresentandFuture Strictly as per the compliance and regulations of: © 2014. -
Biases Inherent in Studies of Coffee Consumption in Early Pregnancy and the Risks of Subsequent Events
nutrients Review Biases Inherent in Studies of Coffee Consumption in Early Pregnancy and the Risks of Subsequent Events Alan Leviton ID Boston Children’s Hospital and Harvard Medical School, 1731 Beacon Street, Brookline, MA 02445, USA; [email protected]; Tel.: +1-617-485-7187 Received: 24 July 2018; Accepted: 21 August 2018; Published: 23 August 2018 Abstract: Consumption of coffee by women early in their pregnancy has been viewed as potentially increasing the risk of miscarriage, low birth weight, and childhood leukemias. Many of these reports of epidemiologic studies have not acknowledged the potential biases inherent in studying the relationship between early-pregnancy-coffee consumption and subsequent events. I discuss five of these biases, recall bias, misclassification, residual confounding, reverse causation, and publication bias. Each might account for claims that attribute adversities to early-pregnancy-coffee consumption. To what extent these biases can be avoided remains to be determined. As a minimum, these biases need to be acknowledged wherever they might account for what is reported. Keywords: epidemiology; bias; causation; coffee; pregnancy 1. Introduction Maternal consumption of coffee during early pregnancy has been viewed as increasing the risk of miscarriage [1–4], fetal growth restriction [2,5–11], and childhood leukemias [12–20]. Unfortunately, many of the epidemiologic studies have not acknowledged the potential biases that appear to have influenced these perceptions of risk. The list of potential biases is long [21]. In this essay, I review five of these biases, namely recall bias, misclassification, residual confounding, reverse causation, and publication bias. Each of these biases might account for some of what has been reported. -
FAQ042 -- You and Your Sexuality (Especially for Teens)
AQ FREQUENTLY ASKED QUESTIONS FAQ042 fESPECIALLY FOR TEENS You and Your Sexuality (Especially for Teens) • What happens during puberty? • What emotional changes occur during puberty? • How are sexual feelings expressed? • What is masturbation? • What is oral sex? • What happens during sexual intercourse? • What can I do if I want to have sexual intercourse but I do not want to get pregnant? • How can I protect myself and my partner from sexual transmitted infections during sexual intercourse? • What is anal sex? • What does it mean to be gay, lesbian, or bisexual? • Can I choose to be attracted to someone of the same sex? • What is gender identity? • When deciding whether to have sex, what are some things to consider? • What if I decide to wait and someone tries to pressure me into sex? • What is rape? • What are some things I can do to help protect myself against rape? • What is intimate partner violence? • Glossary What happens during puberty? When puberty starts, your brain sends signals to certain parts of the body to start growing and changing. These signals are called hormones. Hormones make your body change and start looking more like an adult’s (see FAQ041 “Your Changing Body—Especially for Teens”). Hormones also can cause emotional changes. What emotional changes occur during puberty? During your teen years, hormones can cause you to have strong feelings, including sexual feelings. You may have these feelings for someone of the other sex or the same sex. Thinking about sex or just wanting to hear or read about sex is normal. It is normal to want to be held and touched by others. -
FDA Requests Removal of Strongest Warning Against Using Cholesterol
FDA requests removal of strongest warning against using cholesterol-lowering statins during pregnancy; still advises most pregnant patients should stop taking statins Breastfeeding not recommended in patients who require statins 7-20-2021 FDA Drug Safety Communication What safety information is FDA announcing? The U.S. Food and Drug Administration (FDA) is requesting removal of its strongest warning against using cholesterol-lowering statin medicines in pregnant patients. Despite the change, most patients should stop statins once they learn they are pregnant. We have conducted a comprehensive review of all available data and are requesting that statin manufacturers make this change to the prescribing information as part of FDA’s ongoing effort to update the pregnancy and breastfeeding information for all prescription medicines. Patients should not breastfeed when taking a statin because the medicine may pass into breast milk and pose a risk to the baby. Many can stop statins temporarily until breastfeeding ends. However, patients requiring ongoing statin treatment should not breastfeed and instead use infant formula or other alternatives. What is FDA doing? We are requesting revisions to the information about use in pregnancy in the prescribing information of the entire class of statin medicines. These changes include removing the contraindication against using these medicines in all pregnant patients. A contraindication is FDA’s strongest warning and is only added when a medicine should not be used because the risk clearly outweighs any possible benefit. Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate. -
Maternal Age, History of Miscarriage, and Embryonic/Fetal Size Are Associated with Cytogenetic Results of Spontaneous Early Miscarriages
Journal of Assisted Reproduction and Genetics (2019) 36:749–757 https://doi.org/10.1007/s10815-019-01415-y GENETICS Maternal age, history of miscarriage, and embryonic/fetal size are associated with cytogenetic results of spontaneous early miscarriages Nobuaki Ozawa1 & Kohei Ogawa1 & Aiko Sasaki1 & Mari Mitsui1 & Seiji Wada1 & Haruhiko Sago1 Received: 1 October 2018 /Accepted: 28 January 2019 /Published online: 9 February 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract Purpose To clarify the associations of the maternal age, history of miscarriage, and embryonic/fetal size at miscarriage with the frequencies and profiles of cytogenetic abnormalities detected in spontaneous early miscarriages. Methods Miscarriages before 12 weeks of gestation, whose karyotypes were evaluated by G-banding between May 1, 2005, and May 31, 2017, were included in this study. The relationships between their karyotypes and clinical findings were assessed using trend or chi-square/Fisher’s exact tests and multivariate logistic analyses. Results Three hundred of 364 miscarriage specimens (82.4%) had abnormal karyotypes. An older maternal age was significantly associated with the frequency of abnormal karyotype (ptrend < 0.001), particularly autosomal non-viable and viable trisomies (ptrend 0.001 and 0.025, respectively). Women with ≥ 2 previous miscarriages had a significantly lower possibility of miscarriages with abnormal karyotype than women with < 2 previous miscarriages (adjusted odds ratio [aOR], 0.48; 95% confidence interval [95% CI], 0.27–0.85). Although viable trisomy was observed more frequently in proportion to the increase in embryonic/fetal size at miscarriage (ptrend < 0.001), non-viable trisomy was observed more frequently in miscarriages with an embryonic/fetal size < 10 mm (aOR, 2.41; 95% CI, 1.27–4.58), but less frequently in miscarriages with an embryonic/fetal size ≥ 20 mm (aOR, 0.01; 95% CI, 0.00–0.07) than in anembryonic miscarriages.